#=GF ID   DUF2118
#=GF AC   PF09891.13
#=GF DE   Uncharacterized protein conserved in archaea (DUF2118)
#=GF AU   COGs;
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   COGs (COG4072)
#=GF GA   20.50 20.50;
#=GF TC   20.50 20.50;
#=GF NC   20.40 20.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF CL   CL0105
#=GF DR   INTERPRO; IPR019217;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This domain, found in various hypothetical archaeal proteins,
#=GF CC   has no known function.
#=GF SQ   22
#=GS B8D6F0_DESA1/4-152       AC B8D6F0.1
#=GS E0SQA2_IGNAA/14-153      AC E0SQA2.1
#=GS G0EE93_PYRF1/11-160      AC G0EE93.1
#=GS D5U3E6_THEAM/4-158       AC D5U3E6.1
#=GS R7PSJ1_9FIRM/20-94       AC R7PSJ1.1
#=GS A0A0U3EEE1_9CREN/4-149   AC A0A0U3EEE1.1
#=GS Y859_METJA/4-156         AC Q58269.1
#=GS Q8U1K5_PYRFU/2-163       AC Q8U1K5.1
#=GS Q6M171_METMP/1-150       AC Q6M171.1
#=GS A0A2R4ZU92_9CREN/8-160   AC A0A2R4ZU92.1
#=GS C6A019_THESM/2-163       AC C6A019.1
#=GS D7DV81_METV3/5-160       AC D7DV81.1
#=GS A3DMR4_STAMF/4-160       AC A3DMR4.1
#=GS Q5JEN4_THEKO/2-163       AC Q5JEN4.1
#=GS Q9YB32_AERPE/20-168      AC Q9YB32.1
#=GS A2BK90_HYPBU/13-160      AC A2BK90.1
#=GS A8ABP2_IGNH4/4-149       AC A8ABP2.1
#=GS F0LKP5_THEBM/2-164       AC F0LKP5.1
#=GS I0A0D6_FERFK/8-145       AC I0A0D6.1
#=GS A0A0V8RTM4_PYROC/12-160  AC A0A0V8RTM4.1
#=GS Q8TXA2_METKA/1-162       AC Q8TXA2.1
#=GS F6BEB9_METIK/1-152       AC F6BEB9.1
B8D6F0_DESA1/4-152                  .......................................................................YSFPQLFVEDVDSE...................RIICLKNSEYawAGI..PEK......N.NCT..KY...YGSIPYEE-ILKYID...LEKAIL.K.RSTILFNT...GEPSKALF.FSEN...T.QLCLQ..EAKG.RRVFYIGSM-KHVRKNDLIAYIVTGKNEV.RN..IYSTCEG.FI..LAVIDLTW...ERPERIIVVVA--ie.......................
E0SQA2_IGNAA/14-153                 .................................................ivsynsklyvdlekkifcdkpm--------------...................----------..---..---......A.DDN..RV...FVEIVYEKLPEIAID...FENNIL.R.IDVAIYIP...-SKDIVLF.IKRG...S.NVDIL..EAQG.KIIIPLVNSGESVESNTKVFYRITKKYET.RT..HRAETVG.LV..VYIGEMFI...G------------dsekmiavtvge.............
G0EE93_PYRF1/11-160                 ......................................................................y-LIPRLYIEGIKGD...................EYLVESGEGV..YKR..SKS......CpSGS..RC...YGKAIYGVELDSILD...LLEKKV.K.RSFIVEPG...DKPGEGIL.VESG...V.HAEPI..PVSG.KRAVIEVLEGDEVKEGDVLGLIVTGKYEL.RK..VRSHVDG.IV..VYIYSSPM...GPPDENIVFIVP-r........................
D5U3E6_THEAM/4-158                  ......................................................................y-FFPEAYVENGLESg.................rSICFKGNDIY..IAF..AKN......A.GTG..ECvktFVNTPFEK-LVEYMD...LEKPCF.T.RDVIIVHRe.eGGYYKGFL.IEKG...E.KLYLL..EASG.STIAVSKREGDAVEPHEKIGYIITNKREV.RV..IKAPLKG.IL..LAVIDLTW...EKPEKIIM-----vftge....................
R7PSJ1_9FIRM/20-94                  .........................................................wgesfafvpqmsvl--------------...................----------..---..---......-.---..--...---------------...------.-.--------...--------.----...-.-----..--SG.KTVSVI-AEGTRVKEGDVLVLVDSLVGPV.PA..ARATVDG.VV..IEVT----...-------------vgngqiidqndqvavi.........
A0A0U3EEE1_9CREN/4-149              .......................................................................YEFPKLFVEGIDGE...................-EYLEITDNS..AKI..SKE......P.SSP..K-...LGKVPLEIDLEEIVD...LLGERV.K.RSFAVYNP...-RKKVVIY.VREG...T.PIKIL..RVDH.KKVLIELSEGDEINLDSTYAHGITSKGEY.RR..FRSKVKG.IV..VLVHWKPL...GGRDIYHVIVAE-r........................
Y859_METJA/4-156                    .......................................................................MRIPRLYVENAEKHe................grKVVIENGGKV..IKF..LDK......D.EEY..EG...DGKVLYQVIYDDFDN..yVLMGTV.T.KDMIIEYE..vGGVRQITY.IKKG...T.KLLEI..PAEG.YKVYPIVDFGCRILGGHRIAALQSRKGDI.RF..VNTPVNG.IV..LFLKEVPA...-KRENYVFYILPE.........................
Q8U1K5_PYRFU/2-163                  ......................................................................s-RTPQLYVEVPKEEclegrrvkh.dciviqdniEVRLREGEEV..PEF..IQV......D.KAK..FL...A-KEIYDR-FHFYVD...HYEHRM.K.VDAIIVYP...-DRRTKIY.LKKG...D.ELLLL..PVEG.YVVTLIADVGNRVRKGDAFAAVTTRKGEV.HY..LKPPKPG.TV..VYIDEFTN...--RPHYIYYILPE.........................
Q6M171_METMP/1-150                  .......................................................................MKIPKIYVEGELNDg.................dRVAIEKDGNA..IIF..LEK......D.EEY..SG...NGKLLYQVIYDDLAK..yMSLDTL.K.KDVLIQYP...-DKHTFTY.LKAG...T.KLISV..PAEG.YKVYPIMDFGFRVLKGYRLATLESKKGDL.RY..VNSPVSG.TV..IFMNEIPS...-ERANYVFYMLEE.........................
A0A2R4ZU92_9CREN/8-160              ...................................................gfpyiavssrcvedpdrygk--------------...................RYCVEDPGEN..PVV..TAG......C.SSNcsDC...YVEVPYEEAEQLI--...MGSGVI.K.CGFIIMWE...-GSDQCLL.VREG...V.AAHNI..EIEG.YRVYGIVSEGESVTKGDRIAYIVTGKGEV.RT..VRSSFAG.VV..AYAAQKPE...SKPEKLLLII---ig.......................
C6A019_THESM/2-163                  ......................................................................e-KIPQLFVESNLEEcvdgekarv.dcriiqdniEVKVKKGEKI..PEF..IDP......K.RAK..FM...K-KEVYDR-FHFYVD...KYEHKM.M.CNAIIILP...-DRRTEIR.LYKG...D.ELMLL..PVEG.YVSSIIAGVGNRVRKSDAFAAITTKKGEV.HY..LKPPKTG.VV..VYIDEFTN...--RPHYVYYILPE.........................
D7DV81_METV3/5-160                  .......................................................................MKIPKLYVENNIFEdn..............epcEKIAVSEKEI..IFLdsDEV......V.DNY..KN...THKILYKVRYDDIRS...YIDNDVlK.KDIFVKYP...-GNHTFTH.IKAG...T.YITCV..LADS.KTTYPILDAGSVVLRDGILATLKSNKGVI.RY..LKSPVSG.TV..FFMNEIFE...GNNSIYLFAIVE-n........................
A3DMR4_STAMF/4-160                  .......................................................................YRYPEVFVEGVESD...................KYVLEINEHY..ILV..LTKedlekyV.NYK..RV...FGHIIYEH-IINYID...LVKPAT.K.KAFIVIPEysgEKEMNGFL.IDEN...K.KLCLI..EVKG.IQPYVFPREGDEIEERDKVAYIITGKGEV.RT..IRSPCKG.VV..LLVINFPW...EKPEKYVLAVV--nk.......................
Q5JEN4_THEKO/2-163                  ......................................................................e-KLPKLYVETTQEEcvkdgktla.ecvvimgnvEVWLKENEEL..PDF..IDP......S.RAK..FL...K-REVYDR-FYLYVD...RTEQKM.T.ADVILVLP...-DGRTRIY.LKKG...D.ELMIL..PVEG.FTKTLIANVGNRVRTGDAFAAVTTRKGEV.HY..LKPPKTG.TV..VFIDEITN...--RPHYLYYILPE.........................
Q9YB32_AERPE/20-168                 .......................................................................YRFPELYLEGYVSE...................RAIWVDEEEG..KYY..RRP......V.EGL..KR...YGLAVYEHAIKEAID...LVGSRV.S.RGFVVVIP...WKGMRGLM.LREG...T.RVKLV..EAAG.VQVSHYSLEGTRVGERSVLSYVLTGKGET.RT..LRAGVEG.VV..AIILTDHN...RQPPAYIYVIADE.........................
A2BK90_HYPBU/13-160                 .......................................................................YHIPRIYIEGIGSD...................-EYLELVDST..ARR..TDR......C.SGR..RC...FGKAIYGTLLDEIAD...LLAKKA.T.RSFIVVLP...PDYRKGLL.VEAG...S.YLEPV..PLEG.MRVVIHVCEGDRVEEGSTLGFIATRKFEV.RH..IRSHVEG.VV..VYIYSSPE...GPPDRNIVFIAPE.........................
A8ABP2_IGNH4/4-149                  .......................................................................YKFPRLFVEGKEGE...................EYAVVEGDEV..VFV..KEK......V.PGA..L-...-GKVPYEIPLDEIVD...KLKEEA.K.VTFLIHLP...-NEDKAIL.VPKG...S.KVKLF..KVSH.VKVGVTVKEGDELEEGDTYAYGLTGKGEV.RR..FRSIVKG.KV..VMVHWEPY...GGRDDYHVLVVPE.........................
F0LKP5_THEBM/2-164                  ......................................................................e-RIPQLYVESSYEEcfdkegrakvnciiiqgnvEVRLKKGEKI..PEF..IDI......E.RAK..IL...K-KEVYDR-FHFYVD...KYEHKM.L.CDAIVVLP...-DRRTEIR.LYKG...D.ELMIL..PVEG.YVSTLIAGVGNRVRKSDAFAAVTTKKGEV.HY..LKPPKNG.VV..VFIDEFTN...--RPHYLYYLLPE.........................
I0A0D6_FERFK/8-145                  .............................................................leddkkipsv--------------...................KNYLKSNENI..ESK..LDI......S.LDR..IA...CEEIIFNNI--SFGE...RNICVS.K.GNFIIKTP...---KNSFL.IERN...E.ELKYF..IIEA.SQINTRKKPGDSVKKWDEIAVSKSKKGIL.RR..IKIPFEG.QI..ILVEQDPT...Y-KPERIVFIL--k........................
A0A0V8RTM4_PYROC/12-160             ......................................................................y-LIPQLFIEGLESS...................DYLVLRNGVA..QRS..RGC......P.EGE..RC...FGKAIYGVELESIVD...LVAKKS.R.RSFIVVLP...REYRRGLL.VEAG...S.PVEPI..PLEG.MRVVLEVCEGSRVGVQSTLGFIATRKLEV.RR..IRSHVKG.VV..VYIYSSPE...AGPDKNIVLVAPE.........................
Q8TXA2_METKA/1-162                  .......................................................................MALPRIYVETDEVPesgkil.......ltdpefEVIVRSRELA..EKI..AEE......L.DEP..IF...YEQVVYEE-ARSVFD...VPEAKV.T.RHVVIEPV...-DRRSLVF.LKPG...D.RVYQI..PVEG.YVVTPIADVGDRLRKGDPLAAVTTRSGNV.RY..VEAPQDC.LV..VYVCEQPAirtQRRPNYEYYIAPT.........................
F6BEB9_METIK/1-152                  .......................................................................MKIPRLYVEGETEKne...............grKVVIENDGKV..IRF..LDE......D.EEY..EG...EGKVLYQVIYDDFDK..yILLSKL.T.RDVLIQYP...-DKRTITY.LKKG...T.ELLEI..PAEG.YEVHPIVDFGCRVLEGHRLAALVTKKGEI.RF..VNTPVTG.TV..VFMKEVPA...-KRANYVFYILPE.........................
#=GC seq_cons                       ........................................................................phPplaVEs..tc...................chhlcpscph...th..hc.......s.pst..ph...hs+hlYch.hcphhD...hhtpph.p.pshllhhP....ctcptlh.lccG...s.clh.l...s-G.hplhhhss.GscVccsctlAhlhTpKGEl.Rh..l+usspG.lV..laltphst......sphlhhlh...........................
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