#=GF ID   DUF2119
#=GF AC   PF09892.13
#=GF DE   Uncharacterized protein conserved in archaea (DUF2119)
#=GF AU   COGs;
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   COGs (COG4073)
#=GF GA   30.50 30.50;
#=GF TC   31.30 31.30;
#=GF NC   27.10 29.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR019218;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This domain, found in various hypothetical archaeal proteins,
#=GF CC   has no known function.
#=GF SQ   35
#=GS W9DPD2_METTI/8-192       AC W9DPD2.1
#=GS A0A2U1S611_9EURY/10-210  AC A0A2U1S611.1
#=GS A0A165ZF84_9EURY/13-51   AC A0A165ZF84.1
#=GS A0A133VI04_9EURY/8-196   AC A0A133VI04.1
#=GS Q8TPA8_METAC/87-271      AC Q8TPA8.1
#=GS A0A4E0PW05_9EURY/8-192   AC A0A4E0PW05.1
#=GS Y501_METJA/11-199        AC Q57924.1
#=GS A0A2V3JB38_9EURY/13-216  AC A0A2V3JB38.1
#=GS D5EAG7_METMS/8-191       AC D5EAG7.1
#=GS A0A133U8K9_9EURY/7-195   AC A0A133U8K9.1
#=GS Q6LXP0_METMP/9-200       AC Q6LXP0.1
#=GS R9SIY8_9EURY/10-212      AC R9SIY8.1
#=GS A0A0E3NY57_9EURY/30-214  AC A0A0E3NY57.1
#=GS A0A2V3JKF1_9EURY/11-193  AC A0A2V3JKF1.1
#=GS D3E0I7_METRM/10-215      AC D3E0I7.1
#=GS D7E9K3_METEZ/8-192       AC D7E9K3.1
#=GS A0A166DZ68_9EURY/10-225  AC A0A166DZ68.1
#=GS A0A1D2WAW4_9EURY/10-197  AC A0A1D2WAW4.1
#=GS F0TBU3_METLA/10-197      AC F0TBU3.1
#=GS A0A1F2PB56_9EURY/11-202  AC A0A1F2PB56.1
#=GS Q8TVJ6_METKA/4-185       AC Q8TVJ6.1
#=GS E3GW00_METFV/5-190       AC E3GW00.1
#=GS U6EB44_9EURY/10-197      AC U6EB44.1
#=GS A0A315XK39_9EURY/10-210  AC A0A315XK39.1
#=GS L0L0W4_METHD/8-192       AC L0L0W4.1
#=GS A0A1D3L0N9_9EURY/12-199  AC A0A1D3L0N9.1
#=GS O27672_METTH/13-202      AC O27672.1
#=GS U6E9Q3_9EURY/12-199      AC U6E9Q3.1
#=GS Q12XB2_METBU/8-192       AC Q12XB2.1
#=GS D7DRN2_METV3/10-235      AC D7DRN2.1
#=GS A0A133UH10_9EURY/8-196   AC A0A133UH10.1
#=GS Q8Q0R5_METMA/36-220      AC Q8Q0R5.1
#=GS A0A1V6N4D4_METAZ/10-262  AC A0A1V6N4D4.1
#=GS A0A133UKJ7_9EURY/1-65    AC A0A133UKJ7.1
#=GS A0A133V6I7_9EURY/7-194   AC A0A133V6I7.1
W9DPD2_METTI/8-192                  .e-GKPVRLFVA..GLHGEEWRDTSDILENIE..................-APQK...GTLAVIPL.VNN...GTYISTLDDRYFSE-IGIPIIEAVEELKP..EVYIEIHSYSAENLEALTGVNRLKSIGVPAFSRLD......HDVLLGSVAPYIRRKYFPQDALCLTFEIQKQN-.................................................................PISKEYARKIINQMKEFTSRDEFLTCMLERYPKQARKAIDDYKKFYG..
A0A2U1S611_9EURY/10-210             .g-EGSTKLFVG..GVHGNEGKTAFKFLDKLK..................EEDFS...KGQIFIYN.FDK...SPYISTLDEKYFESPMGKTILELIEDIKP..DFYTELHCYNIKNFEKLTSMDRFNTIGVPPLIDMG......NHVLMGSISPIIRTKYFSVNNICKTLEFPCLDKlnddvv....................................................akynfdmDLSFNTYFNILKTLAIEPNRKSYENKMAELYPKQVDLAIDFAKKIFG..
A0A165ZF84_9EURY/13-51              .g-KGPTKLFVG..GLHGKEGLTTIKLIEQLI..................PKDYN...NGKF----.---...-----------------------------..-----------------------------------......---------------------------------.................................................................-----------------------------------------------yk
A0A133VI04_9EURY/8-196              .g-GRPFRLFVS..GLHGKEHEVTDPILWEFSer..............vsKKNLK...GSLVLHSL.GRE..dREYVSTLDNEYWNTKTGKELLQIVEKYQP..TIYLELHSYSDP--SKLTNPDRIDKKGVPPLIELE......TGILAGSVSPRLRRDKFRKEDFCFLLEIPRDK-.................................................................-GHCEEIYEILKIIGQGMDREDIVEDLKEKFPTQMKKSKKYYELFY-e.
Q8TPA8_METAC/87-271                 .q-GKPVRLFVA..GLHGDEWKDTTEILLKIK..................-PPEN...GILAVIPL.VSK...GEYISTLDPAYYPV-MGTDILKAVEALNP..EVYIELHSYSGENLEKLAGRDRLERIGVPAYSVLK......AGVLLGSVSPWIRREYFPKEALCLSFEIQKGN-.................................................................PLSREFVADMLEVLKETGSRDEFIEYLRNKFPEQAKKAIEDYRRFYG..
A0A4E0PW05_9EURY/8-192              .k-GRPVRLFVA..GLHGNEWKDTTDILENMG..................-APEK...GTLATIPL.VSK...GNYISTLDDNYFTE-AGQVIIDTVEELRP..EVYIELHSYSAENLEKLTGSERLERTGVPAFSQLD......HGVLLGSVAPSIRRKYFPPEALCLTFEIQKEN-.................................................................SLSKQYASKMINRMKEFTSRDEFLKCMLRRYPEQARKAIEDYKKFYG..
Y501_METJA/11-199                   .g-NGVKKLFIG..GLHGNEGKFTEIILKDFVns..............lkECNYI...GDIVVIPK.LVE..nSKYISTLSEKYYESDEGKTLINIIKKYKP..KVYFELHAYKKENYKKLTSNNR---KKVPPLIDIG......NNVLIASISPILR-KRFSKEDFCMTIEIPSWKV.................................................................YEVKDEILKILKIGAESLRREEIIEKLKKIYPEHIEKAEYFSKKYN-l.
A0A2V3JB38_9EURY/13-216             .s-GGTRKLFVG..GLHGDEGLYTAPILETLAseve..........aeaeVGDNY...GDLIIVPS.LTM..gGRYIGVLSEEYYRSREGMILTGLIKRYKP..SFYFELHAYGESSYHRLTNPEREKREGVPPFVDLDdhehthNHILLGSIAPVLR-ELFSAGDFCLTIELPKWRSd...............................................................eEGVREEVMQILRIGLLSETKREMLTQLRKMYPDALKRAEALFIQYY-h.
D5EAG7_METMS/8-191                  .k-GRPYRLFAA..GMHGGEWKDTSSLLMKLQ..................-PPLS...GSLFLFPL.VDR...GRYLSTLQEGYYKG-PGSKIPVFVNNCAP..EIYIEIHSYSKQNFHKLAGRDRISRTGVPPYSVLE......EGLLLGSVSPHIR-LHFPKEALCLSLEVQRDN-.................................................................PASYELALHMLARMKECKGRDDFIAFLKKKYPSAALKAIEDYKKFYG..
A0A133U8K9_9EURY/7-195              .d-GRPIKLFVS..GLHGSEHETTDPILEDYYdr..............msEKAFK...GTLHICRLgMEN...RKYVSTLDSDYWDTKTGKELLSIVEGLRP..SIYTELHSYFDS--SKLTDSERIERKGVPPLVELE......PGILAGSVSPFLRKEAFQREDFCFLLEVPKNA-.................................................................-DSFDKVLEILEIIGFGANRKEIVEDLKKRYPSQMRRLKKYYELFY-k.
Q6LXP0_METMP/9-200                  .n-NVPKKLFLA..GIHGNESKYTSQILENLQkn..............isNLKAS...GNVIIVPE.LVK..dSKYYSTLNPKYYETEEGISLLKLIEKYNP..EFYFEIHSYSKKSYSNLTELKRVDLKGIPPFVDLN......KGVLMASISPILR-EKFKETDFCMTIEVPNWKV.................................................................LEVEKQVLEILEFGILSKNRNEMIEKIFNKYPKAAKTAKWLADEFN-l.
R9SIY8_9EURY/10-212                 .g-DGPTKLFLG..GVHGNEGKTAIKMINRLK..................REDFA...DGQIYIYN.FDS...SPYISTVDKRYYESEMGQKVISLINQYKP..DFYTELHCYNIGHFKNLTSMSRFESQGVPPLIDCG......EYVLISSVSPLIRIKYFTKETICKTLEIPCLHDekkldna..................................................ienygfnpDKSIDRYMDLLYLITRSVSRKDFTERISKYYPTQVDLAREYVKKIFG..
A0A0E3NY57_9EURY/30-214             .s-GRPVRLLVA..GLHGEEWKDTTGILEKLK..................-PPET...GTLALIPL.VSR...EKYVSTLDPRYYPG-MGKPIIETVEKLEP..EIYIELHSYGRENFEKLAGKDRIDRAGVPAYSILK......AGVLLGSVSPHIRRKYFPKEALCLSFEIEKGN-.................................................................LASREFASLMVEKIKEIGSRDEFITCLRKEFPEQAKKAVEDYRRFYG..
A0A2V3JKF1_9EURY/11-193             .s-GEPKRLFVG..GLHGDEWMHTSALLESLD..................-APIT...GTLVIIPK.LTD...RAYVSTLDARYYEG-YGRDLVAAIMEIKP..AIYLELHSYR--DFYGLTDFRRIDKKGVPAYVELE......DRVLIGSISPILRRRCFSVRDFCVSFEIPAEG-.................................................................GESRKLAKELLNFTKDCVSAALFVDFMLSRYPEQGRRAIENYKRFYG..
D3E0I7_METRM/10-215                 .g-EGPTKLFIG..GVHGDEGKHVLPLIKLLK..................REDFS...SGQIYIYN.FDR...TPYISTIHREFYQSEQGKKILDLVDYYKP..DFYTELHSYNIKHFDRLTSLDRLDSEGIPPLIDCG......QYVLCSSVSPLIRRKHFTKEAICQTLEFPIFRGedlklsdde...............................................llekydfdyDLSVKEYMAFLRLITLSKNRDDFEKRVLKDYKKQADLALKYVKIIYG..
D7E9K3_METEZ/8-192                  .s-GDPVRLFVA..GLHGDEWKDTSDILYNLK..................-TPIH...GTLITIPV.VNS...GEYVSTLDESYYKN-KGKIIIDTVIKYQP..SIYVELHSYSGENIVYLTDKNRLKKTGVPAYSKLD......NNVLLGSVAPYIRRNYFSKKALCLSFEIKKSD-.................................................................EKSKQFAAKMADIVKECNSRDDFILFLKQKYPEQAEKAIENYKKFYG..
A0A166DZ68_9EURY/10-225             .g-KGPIKLFIG..GLHGNEGKTTIDFLKSLK..................TNDFS...NGRILIYN.FDK...TPYVSTLKEEYYSSAIGKKLIAIIKRYKP..DFYTELHCYNLKNYKKLISNSRRTIEGVPPLIELR......NHVLMSSVSPLIRMKYFDRNTVCKTLEIPCLDEqflksypdnqntth.....................................vrdnnqinstdfnmESSFKIYLDILKIIAKSNNRSEFENKMKDIYPEQVRLATEFAKDIFG..
A0A1D2WAW4_9EURY/10-197             gy--NPTRLFIG..GVHGKEGLTTIDAISNIS..................ENDVK...NGNLTMYN.FDK...SPYISTLDRHYYGSKRGKEIISIIRDIKP..EMYVELHCYNSNSFSKLTNLNRKESTGVPPLIHLE......KGVLIGSTSPYIRTSLFKEWDVCITLEIPCNYS.................................................................IESLEVYLNVMKAVAGSKDKYELLDRLRADYPEQVKTAAKYAVELY-w.
F0TBU3_METLA/10-197                 .n-HGPTRVFVG..GVHGKEGLTTIEPLKQLS..................QMDVL...NGKLILFN.CPE...SKYISTLDPDYYQTKMGQTIIKIIEKYRP..EIYVELHCYKPSSYQKLINLNRKDEAGVPPLIELE......EGVLISSVAPYLRTELFKRDDVCITLEMPCNPS.................................................................ENSKKVYFEIMQQIATSNNRKEFEAKLRVKYPKQVERARIYAAEFFG..
A0A1F2PB56_9EURY/11-202             .g-EGPVKLFVG..GLHGREGDYTAPILEELAls..............aeNDVFS...ELSIIVPR.ITR..sSRYLHVLSEKYYQSIEGQRLVHFIEKYKP..SFYCELHAYGKESYFMLVSPEREKQQGVPPFVDLK......DGVLLGSIAPILR-RRFGRNDLCITIEIPNWKT.................................................................DEVREMVLELLRIVLGGKTKEGTIEALRRLYPRQIEIARSLFHRY--lq
Q8TVJ6_METKA/4-185                  ..NDHPIRRPVAvyGVHGDEGRALEPVVRRVL..................----P...EGFRVSRV.FEN...GPYVSTVDPSFHRSEVGARWRRVVEDLRP.fDTYVELHCYRPRAYRKLTAERR--SGGVPGLVDFG......AGVLLGSVPR--QHKRILGDVLTLTLEVPRRPS.................................................................DRALRVVSEILGLIP-GRTRGEFVKELRRRFPEATEEALRRFRSYY-p.
E3GW00_METFV/5-190                  .s-SKPVRLFVG..GLHGEESEVTIHALRKIT..................PNIVE...DGKVIIYN.GDK...SRYISTLCEEYYQTPIGKYLIHLILKYKP..RIYVEAHCYNPKNYKKLVDPERRWKYGVPPLIELE......DGILIGSVSPHIRTKYFKKKDVCITLEMPCS--.................................................................CEQLSKYVKILKYIVTSKNRKDLENKMYKEYPKQVEIAREYAREFFG..
U6EB44_9EURY/10-197                 .g-EGLNRLFIG..GVHGKEGLSTVKALEKIQ..................SSDVG...EGKLVIHN.CDT...SPYRSTLDPQYYESKVGREVLYLINHYHP..QIYVEAHCYRTENYHKLTYPGRWDEKGVPPLIDLG......EGVLIGSASPNIRTTLFTRNDVCITLEMPCNPS.................................................................KDSLDVYLDVLRIMASSNNREEVEKRMRNKYPSQVERASQYAQEFFG..
A0A315XK39_9EURY/10-210             .g-KGPTKLFIG..GVHGNEGLTSLKFIKRIK..................DSDLS...LGQFYFYN.FDK...TPYISTIKKEYYESELGLKILDLINYFQP..DFYTELHCYNLKNYEKLTSMERYRKTGIPPLIKLG......NHVLVSSVSPLIRMTYFSTETVCKTLEFPCFEKltpeiv....................................................ekydfnkDLAVKTYEDLLKLILKSPSRDYFERQMLIDYADQVALAVEYARKVFG..
L0L0W4_METHD/8-192                  .d-GDPIRLFVG..GLHGNEWMDTSDILEGLT..................-PPAV...GSLAIIPI.ICK...EKYVSTLEESYYRT-LGRPIIQAVEALRP..SIYIEFHSYSKQNQKLLTGADRIHKTGVPAYSQLD......NDVLLGSVSPVIRKDYFPAESLCLSFEIQKEN-.................................................................RISKDYGSKIAEKMKECLSKEHFIEQLTKRYPEQTKKVMEDYRNFYG..
A0A1D3L0N9_9EURY/12-199             .n-NEPSRLFVG..GVHGKEGITTIKALSQLS..................DDSVS...SGKLRIYN.FDE...TPYLSTINKEYYSSDMGKKVISLIKKYKP..MIYLEAHCYKEKSYEKLVDEDRKSRVGVPPLIELE......EGILMGSVAPFLRLNCFKRQDICLTLEIPCSPS.................................................................KKALDVYVTILKDVASSKTRNDLEETIGSRYPEQVETARRYAIEFFG..
O27672_METTH/13-202                 .g-DGPVRLFVG..GVHGREGLTTIRALRRLG..................FNDIE...NGRLIIYS.CNP...TPYISTLNPDYYRSPQGREILRLIEKYRP..STYLEAHCYRRENYDKLTDPSRKSSEGVPPLIELE......EGVLIGSVSPHIRKKLFKRDDICLTVEMPCLDGg...............................................................sDRSLDVYVEFLRTVASSETREELELRLEGRYPVQVETARRYAREFFG..
U6E9Q3_9EURY/12-199                 ..KDGTSRLVVG..GIHGKEGLSTIKVLEVAK..................DINIP...EGRWTLYN.FPP...SPYLSTLDPLYYLSLRGSQLVSIIQENKP..DIYLELHCYHQENYYKLTKGDRKDIFGVPGLVELE......NGVLIGSVSPLIRSVFFALNDFPFILEIPCNPS.................................................................KEVLKCCQNVMEIIATSSNRKEILQKLGQIYPQQVQQLADYFKEYT-e.
Q12XB2_METBU/8-192                  .k-GRPFRLFVA..GLHGQEWQDTSDVLLNIE..................-RPSS...GTLAILPV.VSR...GKYISTLDGDFYKG-MGKLIVDVVEECQP..DIYVELHSYSSENFHKLVSSTRINEIGVPGFSVLE......NNVLMGSVSPHIRRDHFPVEALCLTFEIERLD-.................................................................QSSKEFAAKMLRVVKECRSRDGFIEYMMERYPNVAKKAIEDYKKFYG..
D7DRN2_METV3/10-235                 .i-QGIQKLIIG..GLHGDEGDDLKPIFDKFKdntntntntnnnnnnnnnNNNLN...SKILVISH.LNKdltEKYVSTISKDFLNTKSAKKLIDIFKKNQNsiNFYIEVHTYEEASYINLTDESRVKKTGVPPLVDIS......NNILVASVSPLYR-NYLNKNTFCMTLEVPKWKLqdikktne................................................ennkennkeNIIMNEVISILNMVIDSDSKDELIDKLFLEYPN-MQKAKNLAIKYN-m.
A0A133UH10_9EURY/8-196              dg--IPIRLFVS..GLHGKEHKYTDLFLKSFAek..............vsEKELK...-GKLVLRS.LARe.eREYVSTLEQEYWNTEAGSELLSIIERVDP..TIYLELHSYT--NYSSLKDPERYEEKGVPPLVDFG......SGILAGSVSPFLRVNKFQRNDFCFLLDIPRDL-.................................................................-NEEAKLMSIMEVIGEGRDRDEILKRLKARFPDQTRRLKRYHRAFY-n.
Q8Q0R5_METMA/36-220                 .h-GKPVRLFVA..GLHGDEWKDTTEILLEIK..................-PPEK...GTLALIPL.VKR...GKYISTLDPDYYPG-MGKGILEAVESLKP..QIYIELHSYSGENFEKLSGRDRMDRIGVPAYSVLK......EGVLLGSVSPWIRKKYFPKEALCLSFEIQKEN-.................................................................FRSGEFVAGILEVLKEAESREGFIEYLKKEFPEQAKKAIEDYRQFYG..
A0A1V6N4D4_METAZ/10-262             .g-EGPTKLFVG..GIHGHEGETTIDFLKSMS..................YSDFS...NGKTFIYN.FDY...TEYISTIKKEYYETKIGKTIINLIKKHKP..DFYIELHCYNIKNYENLISPNRRESQGVPPLIDLE......NHVLISSVSPLIRKKYFKMETVCKTLEIPCINKklywndlnsitkdiitkynitkgnitkgnitednitegniiknnvvkyninmdnanedngnnyhlKSSFNTYLNIIKILSKVKNRDEFQRIMIKKYPKQVELAVKYAKEIFG..
A0A133UKJ7_9EURY/1-65               .m----------..------------------..................-----...--------.---...-----------------------------..-----------------------------------......--------------NKFQRNDFCFLLDIPRDL-.................................................................-NEEAKLMSIMEVIGEGRDRDEILKRLKARFPDQTRRLKRYHRAFY-n.
A0A133V6I7_9EURY/7-194              .e-GRPIRLFVG..GLHGKEYETTELILRDFY..................DRIYGedlEGRIILRS.FRTe.eGEYVSTLNEGFYETPVGKELLSLIHRYRP..SIYLELHSYS--DYSGLTHPERMKRDGVPPLVDLG......MGILAASVSPILR-LQFRKEDFCFLLEVPEGN-.................................................................-KRNGEVLGIMEIIARGSNRWEIIRELRAKYPEEVKQMIRNYLEFYG..
#=GC seq_cons                       .s.stPhRLFVG..GlHGcEtcsThplLcplp...................sshs...sshhll.p.hsc...spYlSTLcpcYYpo.hGppllpllcch+P..phYlELHsYstcsac+LTs.cRhcppGVPPhl-Lc......psVLlGSVSPhlRpchFs+cslChTlElPpts..................................................................tpuhchhhclLchltpupsRc-hlcplppcYPcQscpAhchh+cFaG..
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