#=GF ID   DUF2443
#=GF AC   PF10398.13
#=GF DE   Protein of unknown function (DUF2443)
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Gene3D, pdb_1zke
#=GF GA   25.00 25.00;
#=GF TC   25.80 57.30;
#=GF NC   23.30 20.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR019469;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is a small family of highly conserved proteins from
#=GF CC   bacteria, in particular Helicobacter species, The structure is a
#=GF CC   bundle of alpha helices. The function is not known.
#=GF SQ   30
#=GS A0A3D8IYG8_9HELI/6-84  AC A0A3D8IYG8.1
#=GS T1CPI4_9HELI/1-79      AC T1CPI4.1
#=GS H5VAS8_HELBI/1-44      AC H5VAS8.1
#=GS A0A268TZN6_9HELI/1-79  AC A0A268TZN6.1
#=GS A0A3D8HZV6_9HELI/1-79  AC A0A3D8HZV6.1
#=GS A0A099V2U6_9HELI/1-79  AC A0A099V2U6.1
#=GS I7HEE8_9HELI/1-79      AC I7HEE8.1
#=GS A0A099U1N5_9HELI/1-79  AC A0A099U1N5.1
#=GS A0A2W6MU34_9HELI/1-79  AC A0A2W6MU34.1
#=GS A0A1B1U7L5_9HELI/1-79  AC A0A1B1U7L5.1
#=GS Q7VGZ6_HELHP/1-79      AC Q7VGZ6.1
#=GS A0A329ZKS3_9HELI/1-79  AC A0A329ZKS3.1
#=GS A0A2A2GUB5_9HELI/1-79  AC A0A2A2GUB5.1
#=GS V8CL60_9HELI/1-79      AC V8CL60.1
#=GS A0A3D8HYR2_9HELI/1-45  AC A0A3D8HYR2.1
#=GS A0A3D8IKG5_9HELI/1-79  AC A0A3D8IKG5.1
#=GS A0A268TE91_9HELI/1-79  AC A0A268TE91.1
#=GS V8CDA8_9HELI/1-79      AC V8CDA8.1
#=GS Q7MSV7_WOLSU/1-79      AC Q7MSV7.1
#=GS C5ZYK6_9HELI/1-79      AC C5ZYK6.1
#=GS A0A329ZND8_9HELI/1-79  AC A0A329ZND8.1
#=GS A0A1B8J855_9HELI/1-79  AC A0A1B8J855.1
#=GS A0A4U8UF77_9HELI/1-79  AC A0A4U8UF77.1
#=GS A0A3D8IFX2_9HELI/1-79  AC A0A3D8IFX2.1
#=GS E7G3L5_9HELI/10-88     AC E7G3L5.1
#=GS H5VAS9_HELBI/1-44      AC H5VAS9.1
#=GS F8KTU2_HELBC/1-79      AC F8KTU2.1
#=GS Y1531_HELPY/1-79       AC P64665.1
#=GS A0A3D8HT59_9HELI/1-79  AC A0A3D8HT59.1
#=GS A0A347VPG3_9HELI/1-79  AC A0A347VPG3.1
A0A3D8IYG8_9HELI/6-84             l-LQRIDQIYGEIETAKEELQIALNLACISMQDYILIKRGSKDMPEDLSDWAFEEINTSAQKLKQALDQMNKLRKEFFV-v....
T1CPI4_9HELI/1-79                 .MFEKINEIIARIEEIRDEIQILLGMGKISFVDYIMIKRGSMDMPEHLQMSVLGQINEQVDKLKEQIDLLNKIKREMLVF.....
H5VAS8_HELBI/1-44                 .-----------------------------------MKRGSLDIPDTLNMAFYTQIGEHVEELKEHINALNKYKREMLVF.....
A0A268TZN6_9HELI/1-79             .MFEKIEEIIRNIENLRDEITILLNMAKIDLIDYILIKRGSKDMPEGLSMGMLADIDEEVDKLKKQIDLLNKIKREMLIF.....
A0A3D8HZV6_9HELI/1-79             .MFDKINTIIKDIEDIQQEIKILLGMHKISLIDYIMIKRCSMDYPPHLEMWMLEQIDAEIEKLKSKIDELNKVKKEFLVW.....
A0A099V2U6_9HELI/1-79             .MFERINQIIKNIENIQDEITIALNMAKISLEDYIMIKRGSLDMPEHLNMSLFAAVDEQVMALKKEIDVLNKLKKEWFVY.....
I7HEE8_9HELI/1-79                 .MWEKIDEIFKSIEDIRDDINILLNIAKISLVDYIMIKRGSQDMPEHLSFDLLAQIDVEIDKLKAQIDSLNRLKRELLVF.....
A0A099U1N5_9HELI/1-79             .MLDRINQIIKNIENIQDEINISLRMSKLTLEEYVMIKRGSSDMPESLNMSIFTILDEHVNALKKEIDTLNKLKREWFVY.....
A0A2W6MU34_9HELI/1-79             .MFERIDMILREIENAQAEIQLLLNMAKISFVDYIMIKRGSQDAPEHLGAWNLQQIDNEVSRLKDAIDSLNKIKKEVLTW.....
A0A1B1U7L5_9HELI/1-79             .MLQRIDQMTQEMENAKLELQIALNLVGLSMQEYIMIKRGAQDLPESVSLWALEEVNQRAEQLKHHLDRLNRLKKELFVF.....
Q7VGZ6_HELHP/1-79                 .MFEKIDEIFKNIEDIRDDINILLNIAKISLIDYIMIKRGSQDMPEHLTFTMLAQIDEQIEKLKAQIDALNKLKRELLIF.....
A0A329ZKS3_9HELI/1-79             .MFERIDSIFRNIEEIRDDINILLAMAKISMLDYIMIKRGSQDMPENLTFTLLEQIDTEVEKLKSEIDSLNKLKREMLIF.....
A0A2A2GUB5_9HELI/1-79             .MFERIDSIFRNIEDIRDDINILLGMAKISMLDYIMIKRGSQDMPETLNFTLLSQIDAEVEKLKAEIDSLNKLKREMLIF.....
V8CL60_9HELI/1-79                 .MFEKINEIIIRIEEIRDEIQILLGMGKISFVDYIMIKRGSMDMPEELKMAVLEQINEQVDALKEQIDKLNKIKREMLVF.....
A0A3D8HYR2_9HELI/1-45             .----------------------------------MIKRGSQDMPETLTFALLEQIDAEVEKLKKEIDALNKLKREMLVF.....
A0A3D8IKG5_9HELI/1-79             .MFDKINAIIKDIEDCEEEIRILLSMHKISFLDYVMIKRGSMDYPEHIEIWKLEQIDSYVNKLKAKIDELVKVKKEYLVF.....
A0A268TE91_9HELI/1-79             .MFEKIDEIFRNIESIRDEIQILLNMAKITLVDYIMIKRGSQDMPQDLNMSLFYQINDQIDALKKQIDALNKLKRELLVF.....
V8CDA8_9HELI/1-79                 .MFEKINEIIANIEEIRDEITILLGMAKISFVDYIMIKRGSMDMPEGMQMSVWEHLNEEVDKLKAQIDLLNKLKREMLVF.....
Q7MSV7_WOLSU/1-79                 .MFEKIDLILRGIEASREEIEILLNMAKISFVDYIMIKRGSMDMPEHLGVWNLQQIDTEVAKLKEHIEALNKIKKEVLNW.....
C5ZYK6_9HELI/1-79                 .MFERIDSLLKKIEEAQAEIEFLLRLAKISFVDYVMIKRGSQDMPPSLDMWNLQQIDEEVSKLKEAIDSLNKIKKEVLTW.....
A0A329ZND8_9HELI/1-79             .MFDRIDEIIREIESAREEIEILLSMAKISFIDYVMLKRGEESIPNHVGKWQIQQIDMEVSRMKENIELLEKIKKEVLTW.....
A0A1B8J855_9HELI/1-79             .MFERINEIIAKIEEIRDEIQILLGMGKIDFVDYIMIKRGSMDMPEELQMSVLEQLNEQVDRLKEQIDRLNKIKREMLVF.....
A0A4U8UF77_9HELI/1-79             .MFERIDGILREIEEAQAEITLLLGLAKISFVDYVMIKRGSQDVPEGLGAWNLQQIDNEVSKLKEAIDSLNKIKKEVLTW.....
A0A3D8IFX2_9HELI/1-79             .MFERINQIIKNIENIQDEITIALNMAKITLEDYIMIKRGSMDMPATLSMSLFSQVDEHVMALKKEIDTLNKLKREWFVF.....
E7G3L5_9HELI/10-88                .MFERLDLIIKDIENTKEEIELLLKIAHLSLSDFILMKRGSMDIPETLNMAFYTQIGERVEELKEHINALNKYKREMLVF.....
H5VAS9_HELBI/1-44                 .MFEKLELIIKNIENSKEEIEVLLKIANISLGDFIFDETG----------------------------------------elrhp
F8KTU2_HELBC/1-79                 .MFEKLELIIKNIENSKEEIEVLLKIANISLGDFILMKRGSLDIPDTLNMAFYTQIGEHVEELKEHINALNKYKREMLVF.....
Y1531_HELPY/1-79                  .MFEKIRKILADIEDSQNEIEMLLKLANLSLGDFIEIKRGSMDMPKGVNEAFFTQLSEEVERLKELINALNKIKKGLLVF.....
A0A3D8HT59_9HELI/1-79             .MFERIDIIFRNIEDIRDDINILLGMAKISMLDYIMIKRGSQDMPETLTFTLLGQIDAEVEKLKKEIDALNKLKREMLVF.....
A0A347VPG3_9HELI/1-79             .MFERINQIIRNIESIEDELTIALNMAKITLEDYIMIKRGSADMPEGLNMSLFSQVDEQVMALKQEIDTLNKLKREWFVF.....
#=GC seq_cons                     .MFE+IcpIl+sIEsh+-EIpILLsMAKIShlDYIMIKRGS.DMPEsLshshlpQIDpcV-+LKcpIDsLNKlKREhLVF.....
//