#=GF ID   DUF249
#=GF AC   PF03158.17
#=GF DE   Multigene family 530 protein
#=GF AU   Mifsud W;0000-0002-9805-6461
#=GF SE   Pfam-B_2304 (release 6.5)
#=GF GA   27.40 27.40;
#=GF TC   27.40 31.70;
#=GF NC   26.90 26.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   11238833
#=GF RT   African swine fever virus multigene family 360 and 530 genes are
#=GF RT   novel macrophage host range determinants. 
#=GF RA   Zsak L, Lu Z, Burrage TG, Neilan JG, Kutish GF, Moore DM, Rock
#=GF RA   DL; 
#=GF RL   J Virol 2001;75:3066-3076.
#=GF DR   INTERPRO; IPR004858;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Members of this family are multigene family 530 proteins from
#=GF CC   African swine fever viruses. These proteins may be involved in
#=GF CC   promoting survival of infected macrophages [1].
#=GF SQ   19
#=GS A0A2X0TKE5_ASF/87-279  AC A0A2X0TKE5.1
#=GS A0A2X0RVM7_ASF/86-278  AC A0A2X0RVM7.1
#=GS A0A2X0RTS3_ASF/87-283  AC A0A2X0RTS3.1
#=GS 5057R_ASFB7/87-284     AC Q89925.1
#=GS A0A2X0SDM0_ASF/87-276  AC A0A2X0SDM0.1
#=GS A0A2X0S742_ASF/87-284  AC A0A2X0S742.1
#=GS 5055R_ASFB7/87-276     AC Q89777.1
#=GS A0A2X0RU65_ASF/87-272  AC A0A2X0RU65.1
#=GS 5052R_ASFB7/87-272     AC Q89702.1
#=GS 50510_ASFB7/87-279     AC Q89869.1
#=GS A0A2X0RTR5_ASF/89-284  AC A0A2X0RTR5.1
#=GS A0A2X0RVK8_ASF/89-277  AC A0A2X0RVK8.1
#=GS M1NLY6_9VIRU/84-219    AC M1NLY6.1
#=GS 5059R_ASFB7/87-276     AC Q89740.1
#=GS A0A385KLZ1_ASF/87-277  AC A0A385KLZ1.1
#=GS 5054R_ASFB7/87-280     AC Q89768.1
#=GS 5053R_ASFB7/89-277     AC Q89642.1
#=GS 50511_ASFB7/86-278     AC Q65208.1
#=GS A0A2X0RVA3_ASF/87-280  AC A0A2X0RVA3.1
A0A2X0TKE5_ASF/87-279             .......GALEGDRYDL...IHKYYDQIGDCHKILPLIQDPQIFE.....KCHELSNSCNIRCLLEHAVKHDMLSILQKHKEQI..RLHMALTQILFELACHERKNDIIRWI..GYSLHIHHLETIFDVAFAHKNLSLYVLGYELLMHKVNTE....aAYIELPNLLS.YHLRTAAAGGLLN.FMLETIKHGGYLDK..TVLSAAIRYKHRKIVAHFIHQ...
A0A2X0RVM7_ASF/86-278             .......QALKHNRKDVlecIFSYHLTTPKYHHIMHLTSSQELFEffhlfICKSKNYNARMECLLYAATLYNFPNILEKNREYI..-IRHSIGNSLFAIACKERHIHLIAWFvtAGVLDTYDDSTLFNTAFRLGDYSLLEVACDL--------.....PIIYPDYLII.SMMQTAIQKNYFR.FFKKLLTHFNIYRP..IIITDAAYYNRRKILLLLLNQ...
A0A2X0RTS3_ASF/87-283             .......GALRTENYNL...VCEYHSQIQDWHVLLPLIQDPETFE.....KCHDLSLECDLSCLLQHAVKYNMLSILVKYKEDLlnVLFRQQIQGLFILACENRKLEILTWM..GQNLPIPDPEPIFSIAVVTKDLEMFSLGYKIVFEYMENQgl.hlTQVVRMVMLN.HHFGMVINKGLLP.FVLEILNYGGNVN-..RALSYAVTQNKRKILDHVVRQ...
5057R_ASFB7/87-284                .......GALKTENYNL...VCEYHSQIQDWHILLPLIQDPETFE.....KCHDLSLGCDLICLLQHAVKCDMLSILVKYKEDLlnVRIRHRTQSLFVLACENRRFEIIEWI..GQNLSIPEPEAIFSIAIVTKDVELFSLGYKIIFDYMQRQgifqlTNVVRMLLLN.RHIGMAIEKGLLP.FILETLKYGGSVK-..RALSYAVIDNKRKIIDYLVRH...
A0A2X0SDM0_ASF/87-276             .......GALEGRQYDL...IQKYYNQIGDCHQILPLIQDPEIYE.....RCHELNVTCTFQCLFQHAIRDNMLPIFQKYGEDL..NGNRRMVQLLYEMACRLQNYDIIKWI..GSNLHVYNLEAIFSIAFVRKDLTLYSLGYMLLLGRMSTE.....-DRNFISIIT.RHLEYASKKGLFD.FVLESLKYGGQVD-..TVLFQAVKYNHRKILAHFIH-e..
A0A2X0S742_ASF/87-284             .......GALKTEKYNL...ICEYHSQIQDWHILLPMIQDPETFE.....KCHDLSLGCDFICLLQHAVKYNMLSILVKYKEDLlnARIRHRIQSLFVLACENRRIEIIDWI..GQNLPIPEPDAIFSIAVATRDLELFSLGYKIIFDYMQRQgiiqlTNGVRMVVLN.RHISMAIDNGLLP.FVLETLKHGGNIH-..RALSYAVTHNRRKILDYLIRQ...
5055R_ASFB7/87-276                .......GALESDHYSL...IRKLYDQIEDCHDILPLIQDPKIFE.....KCHELDKFCNILCLVLHAVKNDMLCILQEYKMHL..SGED--IQVVFETACRSQKNDIVSWM..GQNIAIYNSGVIFDIAFDKMNVSLLSIGYTLLFNHHINN.....TNENINSLLT.QHLEWAAGMGLLH.FMLETLKYGGDVTI..IVLSEAVKYDHRKILDYFLR-r..
A0A2X0RU65_ASF/87-272             .......GALQGDQYDL...IHKYENQIGDFHFILPLIQDANTFE.....KCHALERFCGVSCLLKHATKYNMLPILQKYQEEL..SMRAYLHETLFELACLWQRYDVLKWI..EQTIHVYDLKIMFNIAISKRDLTMYSLGYIFLFDRGNTE.....-----ATLLT.QHLKKTAAKGLLH.FVLETLKYGGNID-..TVLTQAVKYNHRKLLDYFLRQ...
5052R_ASFB7/87-272                .......GALQGDQYDL...IHKYENQIGDFHFILPLIQDANTFE.....KCHALERFCGVSCLLKHATKYNMLPILQKYQEEL..SMRAYLHETLFELACLWQRYDVLKWI..EQTMHVYDLKIMFNIAISKRDLTMYSLGYIFLFDRGNTE.....-----ATLLT.QHLEKTAAKGLLH.FVLETLKYGGNID-..TVLTQAVKYNHRKLLDYFLRQ...
50510_ASFB7/87-279                .......GALEGDRYDL...IHKYYEQIGDCHKILPLIQDPQIFE.....KCHELSNSCNIRCLLEHAVKHNMLSILQKHKDQI..RLHMALTQILFELACHERKNDIIRWI..GYSLHIYHLETIFDVAFAHKNLSLYVLGYELLMHKVNTE....aANIDLPNLLS.YHLRTAAAGGLLN.FMLETIKHGGCVDK..TVLSAAIRYKHRKIVAHFIHQ...
A0A2X0RTR5_ASF/89-284             .......GALEGNRHDL...IRKYDDQIKDHHEILPFIDDPVIFH.....KCHIMRQ-CFFDCILYQAVKYSKFRVLLYFKHRL..EDDLPFTHLLIEKACKDHNYEVIKWI..YENLHIYNMIDTFECAIAHKDLHLYCLGYRFIYNRIVPDk...yHHLDIRMLSSlQLLHKVAAKGYLD.FILETLKYDHNKDNinIILTQAATYNHRKILIYFIP-q..
A0A2X0RVK8_ASF/89-277             .......GALESKYYDL...VYKYYDQVKDCHDILPLIQNPETFE.....RCHELNSTCSLKCLFKHAVINDMLPILQKYTDYL..DRWEYCSQMLFELACSKKKYEMVVWI..EGVLGVGKVTSLFTIAISNRDLQLYSLGYSIILENLYS-.....CGQDPKFLLN.HFLRDVSIKGLLP.FVIKTIEYGGSKE-..IAITLAKKYQHKHILKYF---et.
M1NLY6_9VIRU/84-219               likfmea----------...-------------------------.....--------------------------FRDLGYDI..KTKSTYLNAAFKIACKFRQIKMIKWL.iENDFDINFDPELFNVACYHDDTDVCKTLLELGFHVDITK.....--NETQELLI.YILKNK-KMDLIDlFIKHNINF-NPLSS..YINNLPLDQNNEKIINVL---trn
5059R_ASFB7/87-276                .......GALEGRQYDL...IQKYYNQIGDCHENLPLIQDPEIYE.....RCHELNVTCTFQCLFQHAIRDNMLPIFQKYGEDL..NGNRRMVQLLYEMACRLQNYDIIKWI..GFNLHVYNLEAIFSIAFVRKDLTLYSLGYMLLLGRMSTE.....-DRNFISIIT.RHLEYASKKGLFD.FVLESLKYGGQVD-..TVLFQAVKYNHRKILAHFIH-e..
A0A385KLZ1_ASF/87-277             .......GALESDHYSL...IRKLYDQIEDCHDILPLIQDPKLFE.....KCHELDKSCNILCLVLHAVKNDMLCILQEYKMHL..SGED--IQVVFETACRSQKNDIVSWM..GQNIAIYNPEVIFDIAFDKMNVSLLSIGYTLLFNHHINN.....TNENINSLLT.QHLEWAAGMGLLH.FMLETLKYGGDVTI..IVLSEAVKYDHRKILDYFLR-rk.
5054R_ASFB7/87-280                .......GALEGDHYDL...IHKYGSQIEDYHMILSSIHNANTFE.....KCHELSN-CDMWCLIQNAIKYNMLPILQKHRNIL..-THEGENQELFEMACEEQKYDIVLWI..GQTLMLNEPEFIFDIAFERIDFSLLTMGYSLLFNNKMSSid.ihDEEDLISLLT.EHLEKAATKGCFF.FMLETLKHGGNVNM..AVLSKAVEYNHRKILDYFIRQ...
5053R_ASFB7/89-277                .......GALESKYYDL...VYKYYDLVKDCHDILPLIQNPETFE.....KCHELNNPCSLKCLFKHAVIHDMLPILQKYTYFL..DGWEYCNQMLFELACSKKKYEMVVWI..EGVLGIGKVTSLFTIAISNRDLHLYSLGHLIILERMQS-.....CGQDPTFLLN.HFLRDVSIKGLLP.FVLKTIEYGGSKE-..IAITLAKKYQHKHILKYF---et.
50511_ASFB7/86-278                .......QALKHNRKDVlecIFSYHLTTPKYHHIMHLTSSQELFEffhlfICKSKNYNARMECLLYAATLYNFPNILEKNREYI..-IRHSIGNTLFAIACKERHIHLIAWFvtAGVLDTYDDSTLFNTAFRLGDYSLLEVACDL--------.....PIIYPDYLII.SMMQTAIQKNYFR.FFKKLLTHFNIYRQ..IIITDAAYYNRRKILLLLLNQ...
A0A2X0RVA3_ASF/87-280             .......GALEGDQYDL...IHKYDSQIKDYHMILSLIQNANTFE.....KCHQLSN-SNMWCLIQNAIKYNMLPILQKHRNIL..-THEGENQELFEMACEEQKYDIVLWI..GQTLMLNEPEFIFDIAFERIDFSLLTMGYSLLFDNKMSSid.ihDEEDLTSLPT.EHLEKAATKGCFF.FMLETLKHGGNVNM..AVLSKAVEYNHRKILDHFIR-r..
#=GC seq_cons                     .......GALcucpYDL...IpKYasQItDhH.ILPLIQDPphFE.....KCH-Ls..CshpCLlpHAlKasMLsILQKa+-pL..ptccthsQhLFElACcpp+h-llpWI..upsLtlhcscslFsIAhs++DloLaoLGYpllhpph.sp.....st.shhsLLs.pHLcpAutKGLLp.FhLETLKaGGslc...hlLotAlcYNHRKILsaFl+....
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