#=GF ID   DUF2540
#=GF AC   PF10802.12
#=GF DE   Protein of unknown function (DUF2540)
#=GF AU   Pollington J;0000-0002-8158-8998
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   PRODOM
#=GF GA   25.00 25.00;
#=GF TC   25.30 98.70;
#=GF NC   23.90 21.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF CL   CL0057
#=GF RN   [1]
#=GF RM   27845039
#=GF RT   Crystal structure analysis of a hypothetical protein (MJ0366)
#=GF RT   from Methanocaldococcus jannaschii revealed a novel topological
#=GF RT   arrangement of the knot fold.
#=GF RA   Thiruselvam V, Kumarevel T, Karthe P, Kuramitsu S, Yokoyama S,
#=GF RA   Ponnuswamy MN;
#=GF RL   Biochem Biophys Res Commun. 2017;482:264-269.
#=GF DR   INTERPRO; IPR024254;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family of proteins includes the uncharacterized protein
#=GF CC   MJ0366 from Methanocaldococcus jannaschii and similar proteins
#=GF CC   predominantly found in Methanococci. This protein adopts the 3-1
#=GF CC   trefoil knot conformation [1].
#=GF SQ   6
#=GS Q6M002_METMP/6-80       AC Q6M002.1
#=GS F6BBZ8_METIK/7-81       AC F6BBZ8.1
#=GS Q6LZ85_METMP/6-80       AC Q6LZ85.1
#=GS Y366_METJA/14-88        AC Q57812.1
#=GS D7DQS3_METV3/4-78       AC D7DQS3.1
#=GS A0A7G9VYQ6_9VIRU/11-85  AC A0A7G9VYQ6.1
Q6M002_METMP/6-80                  .HLNLIEEIDAIAVRYFLHQIQNLESVDVEKLGKASKLPKKCSRTLKLSEEEQKIIKKAGKLTGHLVNYVILTERE...
F6BBZ8_METIK/7-81                  .TFYLCKNVDSRRLRYYLHKLENLKELDPEMFKKVIESKKECRRTITLTEEEIKICEKYGRATNLYLNYVIMVSED...
Q6LZ85_METMP/6-80                  .TLGLIENVDRRTARYILHKVEDMNAISPDILKKATEPKKQFRKTLSLSDIEKKIVEKHGKATSLLMNCYIVMNRE...
Y366_METJA/14-88                   .TFYLYKNIDGRKLRYLLHKLENVENVDIDTLRRAIEAEKKYKRSITLTEEEEVIIQRLGKSANLLLNCELV-K--lde
D7DQS3_METV3/4-78                  y-FNLYKNIGARELRYYVHKMENCENIAPETIAEIKNRNLKTKKLLTLSDKENEIVSRYGIGANFLLNCIIFQEEE...
A0A7G9VYQ6_9VIRU/11-85             .TFYLCKNIDGRKLRYLLHKLENVENIDIETLRRAIEAEKKFKRSLTLTEEEEAILERLGKSANLLLNCELV-K--lde
#=GC seq_cons                      .TFhLhKNIDuRcLRYhLHKlENlEslDsEpL++AhEscKKh+RoLTLoEEEpcIlc+hGKusNLLLNChIl.cc-...
//