#=GF ID   DUF257
#=GF AC   PF03192.17
#=GF DE   Pyrococcus protein of unknown function, DUF257
#=GF AU   Mifsud W;0000-0002-9805-6461
#=GF SE   Pfam-B_2788 (release 6.5)
#=GF GA   25.00 25.00;
#=GF TC   29.30 28.80;
#=GF NC   24.90 22.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF CL   CL0023
#=GF DR   INTERPRO; IPR005489;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF SQ   33
#=GS C6A2K7_THESM/12-215  AC C6A2K7.1
#=GS C6A4N1_THESM/10-211  AC C6A4N1.1
#=GS Q5JDR1_THEKO/5-202   AC Q5JDR1.1
#=GS F0LIP3_THEBM/8-209   AC F0LIP3.1
#=GS C6A4K7_THESM/9-213   AC C6A4K7.1
#=GS Q5JGS6_THEKO/9-199   AC Q5JGS6.1
#=GS F0LIA1_THEBM/7-214   AC F0LIA1.1
#=GS Q5JIQ7_THEKO/15-222  AC Q5JIQ7.1
#=GS C6A2Z1_THESM/8-205   AC C6A2Z1.1
#=GS F0LL46_THEBM/7-210   AC F0LL46.1
#=GS C6A2J4_THESM/6-208   AC C6A2J4.1
#=GS F0LH66_THEBM/1-169   AC F0LH66.1
#=GS C6A1U0_THESM/6-211   AC C6A1U0.1
#=GS F0LH61_THEBM/9-213   AC F0LH61.1
#=GS F0LH87_THEBM/10-213  AC F0LH87.1
#=GS F0LLQ1_THEBM/8-211   AC F0LLQ1.1
#=GS F0LLM9_THEBM/10-216  AC F0LLM9.1
#=GS C6A111_THESM/7-199   AC C6A111.1
#=GS F0LH62_THEBM/7-211   AC F0LH62.1
#=GS F0LH20_THEBM/10-223  AC F0LH20.1
#=GS Q5JHI6_THEKO/8-210   AC Q5JHI6.1
#=GS F0LLN0_THEBM/5-212   AC F0LLN0.1
#=GS Q5JIQ6_THEKO/18-220  AC Q5JIQ6.1
#=GS Q8U4C6_PYRFU/5-188   AC Q8U4C6.1
#=GS Q5JDR2_THEKO/4-194   AC Q5JDR2.1
#=GS C6A112_THESM/11-215  AC C6A112.1
#=GS C6A511_THESM/11-212  AC C6A511.1
#=GS C6A399_THESM/1-167   AC C6A399.1
#=GS Q8U187_PYRFU/8-207   AC Q8U187.1
#=GS C6A4N0_THESM/9-214   AC C6A4N0.1
#=GS Q8TZT8_PYRFU/9-204   AC Q8TZT8.1
#=GS Q8U186_PYRFU/7-214   AC Q8U186.1
#=GS C6A1H3_THESM/10-220  AC C6A1H3.1
C6A2K7_THESM/12-215             ....sill----GIKPGETVLVEYTPI.SSP.E.ILLY..LMITKC.M...KRGVPVIIDDIA...D....T.FSEYITRL....KILGVPTED..lL...NAPVIKIG.G.DKNVGKVLGNVEIRR-YSLDFVA.......YSEVYEKVAPK...EIV..CNPVLGIHKL.FVS..LD-.LQDARG..LVRNI..ASFV.GNETRFAVYFINREILKEKSLE.ILGLLEEISTSVFRWELHKE.V......YKLSVIKSPNPDILGSE--fs...........................................................
C6A4N1_THESM/10-211             .......d-VMDKTPFGDLVLIEDETS.YGS.V.LVAY..ALLRYA.R...ERGMKIMIDDIL...D....S.LFLVKKHL....EFFGIREDF...S...NAIVIKTG.G.KMDVGNVIRKIPLEPELVIYLSR.......YESLINEIFSI...GEY..INIILNPERL.FAF..VEK.PTELYM..VINFI..QGFL.GNKSRKAFYIIDKNIASTLKFN.PIPELEGIATTVAYIRGENG.K......GKVTFGK------------tpfielldr....................................................
Q5JDR1_THEKO/5-202              ........EYLETLRPGESVLVEHTSI.SPY.P.VLFY..EIGKNS.G...WDN--ILVIDII...D....S.ALPVLRWL....KFAGLDVPE...K...SIARIKAG.G.TSEWGRIVIDVDPHKDPGIFMSKflsnllsYYRANKNV---...---..TTIIMNPERI.IPL..QDN.RPSFVL.yLANAA..AGFL.GNPHRKTFYFVNYELAHKGY--.-LALLEEAFTRVLRIEDSS-.-......--VRILKSLNLDEEGTTLQ.............................................................
F0LIP3_THEBM/8-209              ..kflkgh-----VRGGDVVLIEYPSA.YPF.EdLAWG..EIIPEI.S...HDN-QIVVDDFF...GigdlS.FRNYIRKI....SPKDYRRIIeitK...HIKVIKIGpG.RASYGSIVDEIPLTYEISEFMKN.......YYDAIRKALVD..sIKP.lYFLSFGLSEY.FYF..GKE.RAIQA-..-ILFS..RSNL.PVEDWTSIYLINKNLVEMPQ--.-LAILEDISAWIIDINQEE-.E......YTVKIKK------------gnge.........................................................
C6A4K7_THESM/9-213              .......r-LLDSLKWGETVLLEHDSL.TSS.V.QGLY..YIIKWS.M...ERNYPVVVDDFL...D....T.FYLYATHM....KLAGFNTSI..lN...NVKVIKLG.G.KLKVGDIVTRLPVNE-PEVYEKK.......YAEVTGSLFKQ...GKV..INPVLGFERL.LMF..TNS.NQEILM..ELNAV..LEYI.GNEKRIAFYIINEEVIEKSNPC.IEFLLREMATTVIKISKKES.R......TVFSILRSVNNEIDGKEI-i............................................................
Q5JGS6_THEKO/9-199              ........DFIRAIVPGDIVLIKYSSN.APVeK.IAWG..EIIPSI.H...DHG--IVSIDFW...G....I.GDILMRKF...aKTSGVEYTKi.lDvirEIKIIKIGpG.AASYGEVLEDIVPTYEPQNFLRN.......YHSILSRISRL..pRKP.kYAVVFGLSHY.IYF..--N.PEKALK..SILTA..VGTI.PAGDLAIISFVNTSILNEAH--.-IGILEELSTKVAEVS----.-......-------------------ggkiiva......................................................
F0LIA1_THEBM/7-214              ....efif---SKMRAGETVLIEYASV.SSP.E.ILLY..VMERYC.R...QNDIPMIIDDIA...D....T.LPEFLTRL....ELIGLLIKG..fG...SIPVIKIG.G.HRESGEIVGRIDIEK-YSLDFQY.......YNPVYEKVRPS...KMA..YNPVLGIHKL.LLInsIKE.YGGGVR..LLRNI..SRYV.GNKTRIAFYFINKSLVQSKFPE.FLYLFEEIATSVMQWERSGS.T......YKLKVIKSANDDILEK---iat..........................................................
Q5JIQ7_THEKO/15-222             ........HLVETIQPGETVLIEHRTS.YVP.E.FTLK..LVADYT.K...ENGVPLVIDDNF...D....T.LYTLILHL....RLMGVEVDL...D...HAYVIKTG.G.THNIGGKVKRIEFHPDPRVFLRN.......YTNASSEILVE..gKTP.aINLVLGLENI.LMI..MRD.SRDFYR..LLLSL..QRYV.GNKNRIALYLINRNIVESMMPGfFLPELERIATTVIETNSYPT.G......AILTFKKSINPAVIGTTV-g............................................................
C6A2Z1_THESM/8-205              ....efle---KNVTLGDFVLIEYPSSySIT.K.LLWG..ELVPEI.S...QKE--VLIDDFFgigD....LlFRGYLRKT....PPEEYKKAMeitK...NLRAIRIGvG.RTSYTSIAEEIPITYEVSEFMKN.......YYNALMKLFSV..sTKV.eYSITLGVSQY.IYF..GGE.KA-L-K..AILFT..RSTL.PFEDWTSIYFVNKDILDERQ--.-LAILRELANWRLKIKREES.A......YKM----------------eiee.........................................................
F0LL46_THEBM/7-210              ......ei--WDSIKFGETVLVEHSSL.ASP.V.KGLY..HLIEWA.K...RKGYGVIVDDIL...D....T.LYLYRIHM....KLAGYDESI..lD...SITVIKEG.G.KVNVGSVVKRFPIEE-PSVYEQE.......YGKIFSSVVK-...GKV..INPVVGFEKL.LFL..ANS.KQDLLS..MINIT..LSFC.GNDKRIAFYFVNADMAERINPE.VMPLLEEVATTVIRIIKEGT.S......HMFMVLKSVNENMEGMKV-r............................................................
C6A2J4_THESM/6-208              ......iw---DSLKFGETVLLEHDSL.MFP.Y.KELA..ELTAWS.K...KRGYFLVIEDIL...D....T.LYTYKSQM....ELAGIDSKI..lD...NIKVLKTG.G.RLEVGNVITRFQVSD-ILSLTKE.......FEMNYEHILSR...IEH.aTVPIVGLDKL.FLL..AES.KLEILA..LVNTI..ARYA.GSRKRTAFYFINTDVLMNNIPY.VIPLLEELASTVIKIYKDD-.E......KTFKIIKSTNNRLWK----afq..........................................................
F0LH66_THEBM/1-169              ......mr-------------------.---.-.----..------.-...-----VLVDDFL...D....T.LYIYKVHL....ELSGTDTSK..fE...DLQVIKIG.G.VKSVGKIVGKISSRG-GVILRRE.......YQMIYENAIDD...GSL.vINPVLGIEKL.LIL..GSS.RLEVLE..TLAEI..SSRL.GDKRRIAVYFVDKSVLKTGEFN.PLPIMEFLSTTVVNVEKRGR.V......YTFEVLKSINPELDGKT--ys...........................................................
C6A1U0_THESM/6-211              .......d-ILDNIQLGETVLIEYSSK.VAP.I.LFFS..ELVDWA.K...EKGYSAVVDDIL...D....T.LYLYKVQL....ELVGANMSF..lN...DLKVIKFG.G.RFNVGQIFGRLHIER-PEIREQK.......YKEFFGPLLEE..gKTV..VNPVLGFEKI.FLL..QES.KADILN..LMNET..LSFV.GEKPRIALYFINSDVLESTAPE.ALPLFEELASTILKVDIEGK.L......YKFSVVKSVNNNLLGL---eft..........................................................
F0LH61_THEBM/9-213              ........EYLGSIKFGESVLVEYSPE.API.P.IIFR..ETIEFLlK...KYN--VLILDIF...D....T.LHMIKEPL....KIMGWDAEK..lD...KIDVVKAG.G.IINTGNIVKRIDISKDPAVYTLE.......FAEFMREYYAT...HRP.tVLIALGIDKL.IRL..YTN.EVTSFEihIAGVM..KKFL.GERSRLSLYFANMALVPKET--.-LYEWEEIVTRVFEITLKGKmK......FVIKVKKSPNIE-------dhekef.......................................................
F0LH87_THEBM/10-213             .......r-IMDSLKMGETVLLIYDES.LIP.E.FSFL..FFVEYA.S...QKGVPVIVDDIL...D....S.LYVIKQHL....EFIGIDTKF..fE...NITVIKVG.G.TNIVGNVRQHIPLEG---AYREK.......YRLAVREVYKE...KSN.aINLVLGIENL.FYL..STK.PSDVMD..VISEL..ISFL.GEKSRIAVYIINKNITEKAPVN.PLPFFERIASTVIYTESHPR.K......AVLRIGKCSSLELVGKS--lv...........................................................
F0LLQ1_THEBM/8-211              ......iw---DSLKFGETVLLEHSAT.TPT.A.LGLC..HLIKWA.K...GKEYDVLIDDIL...D....S.LYLYKMHM....KLSGCGDEI..lD...NVRVIKTG.G.RLEVGKVIERLSIKE-PVIQEQE.......YRRVFGPLLEE...TKV..VNPVVGFEKL.LLL..TNS.KREIIT..TLNNI..LSFV.GDERRIAFYFINVDVLESITPR.VLPLLEEIATTVVRITKDGR.S......FRFAVVKSINNEIDGMEI-k............................................................
F0LLM9_THEBM/10-216             .......e-HFSKIKPGEIVLIEYTPD.SFY.P.IAFY..VLATYS.L...KLGLPLLIDDIL...D....T.LHLYKTYL....DFAGLNTDFlysE...DVFVLKIG.G.HKEVGNVVSEIRLTGEFYIQYEN.......YKAAFDSILSQ...RDF.fINIVLGFDRL.TDL..YPS.YQR-YL..FLLTR..THYL.GNKRRTAFYFVNRELLKKT-PL.VLPIFEEISTSVVRLEKEGN.T......ILVTFLKSPYPSLVGSQ--fk...........................................................
C6A111_THESM/7-199              ........EFLNDIREGERIFIEYEST.THP.E.LFLD..GLVKWS.N...EEGIPILIIDML...D....I.FHLFVQQL....RFLGYKTHH..lE...NLCVIKGG.G.RVEFGKVIGRVRIMEEFYVQLKE.......YTDAVRLFFEKaksDKA..VIVFLGTEKF.LYS..FQE.------..-----..----.----------------------.--------------------.-......-------------------ssyrveeyfekivrsplfegnmifvfalkglmgaqvralwyesstrvleingrgdrffikk
F0LH62_THEBM/7-211              ........EFLEKVQPGETILIEYSSI.DHP.E.IVFY..SITKWA.E...ENGLPIVIHDVL...D....T.FHIFVEHL....KLNGYDVEF..lK...DVYVIKSG.G.MIQLGKIIRKVKLSDDIVVYTRN.......LHEILRELFTKi.eKRP.iIIIVLGAGKH.LKR..YEH.QPRVLE..YFFEVvtRKCL.GNTNRITYLFGNPHLLRHDV--.-KVELEEAPTRILELKEYGR.K......VVIK--K------------spylselmeel..................................................
F0LH20_THEBM/10-223             ......rl--WESLAPGESILAEYDSL.VLP.Y.KGFH..YLISWA.E...KRGHSIMIIDVL...D....T.LYLYKTQL....KLAGVDTGI..iD...KASVVKIG.G.RLKVGNVLKRLPAND-IPKLLKDfe...gfYSEYLRKV-QN...HSG..IVIVLGLSKL.LLL..AES.KFEGLM..VIDLL..IKYT.GTSGRIAFYFVNVDVLENSSRY.LIPLLEELATTVIRVERARK.EediepyVYVTVAKAINAELEGFKI-k............................................................
Q5JHI6_THEKO/8-210              ........EFLSAFYPGETVMIEYDTV.SMP.E.VLFY..LI--YL.N...RENRPVLIDDVA...D....T.LCETLTKL....EFMGFDVSG..fN...DVPVIKIG.GgERNCGNVLGEVDVDR-YSLDISY.......YGRIVEKASFN...DVV..LNPVLGVHKL.FLA..LER.RGALR-..LVKNI..ATFE.GDKRRIAFYFINRDVVEMSYPE.LLPLLEEIASTVMNWSFEGE.E......FVLYVSKSANLNIMGKGI-s............................................................
F0LLN0_THEBM/5-212              ........ELLESFKRGETVLFLYPPI.SPS.Y.ILLR..KVVEYC.K...KRGLDLYVADIF...D....M.LYTYKTQL....EYIDIELDLd.dD...RISVIKEG.G.KIHVGNVISRISVDEDAAIHLRK.......YEEAFESSLQD...KEF.vFDVTLGFDKL.LAF..YSEsPKDLKM..ILMAV..KDFV.GNKKRTAIYFVNQEVVANIG-N.ALEFLIDSATSVIKLEKDAD.G......WYIRVLKSPKIEIVGAKV-k............................................................
Q5JIQ6_THEKO/18-220             .......g---KNLKPGSLVLIENISS.PGA.K.LSFY..ALLKVS.K...EKGIPLIVEDIF...D....T.LPIYVKHI....ELMGFHVPS...E...SINVIKVA.G.IDSVGNVVEKLSFEADPNFYIPK.......KERAVSKIVGD...NTP.hILLILGLERL.LMF..QRN.LRDLYP..IVRYF..RENL.NSPNRATISIIETPVLNSIKPN.PLPMLESVASSVIELYMENE.A......LIVRPKKALSLFTVNA---er...........................................................
Q8U4C6_PYRFU/5-188              ........EFISQLKLGETVLVEHSSY.SKP.E.LLFY..GI---I.K...ESRMPVVIDDIL...D....T.LFEYYNKL....KVWGYDLTV..fD...KVYVIKAG.G.NEVIGNLLGKLEVGK-YVIEARE.......YTKIIKEVNP-...-PI..INPVLGVHKL.ILL..-GN.LLENLR..LLKEI..STYV.GNENRVAIYFVNRDVVESHSPA.ALKLLEEISTSVFQLNEENK.I......-------------------krmk.........................................................
Q5JDR2_THEKO/4-194              eiletiea------RGGGLVLVEYSSL.DHP.E.LVFA..EIITGW.R...EKGIIPLIVDIG...D....T.LHIFTSKL....RMMGVNIEV...E...DFPVVKEI.G.NTRVGNIVGEVHEIEDFDYHMAK.......YAQIAKKVPEE...SKK..HTIVLGMEKFsFTF..MDN.PPKLER..YFEKI.nRRYL.KYPDVKDVIFLNTSVASEYL--.-TKSLE--------------.-......-------------------qdydyvlrlrgtdlslvkt..........................................
C6A112_THESM/11-215             ........EYAKSVMWKEGIVIEYSSS.EPI.H.LIFK..WLVGIS.E...KITDNILVLDVL...D....I.LSMLKLNL....DIAGKDTSF..tH...ELDVIKIG.G.NIKLGKMIGYLDPHQDITVYASR.......YSKILREYYET...HKN.iVYFIFGIERL.VHL..QER.EEVFEL..YATNY..TRYVfGDEERVGIYFINRDIATKAL--.-LLQLEEAASRVLEVIHEEG.T......LKIKIRKSPRLEDYGKE--fk...........................................................
C6A511_THESM/11-212             ........EFFDKLKPGEIVLVEYSSR.DDP.T.LFVA..EIARWA.D...AKKYQLLVTDLF...N....T.VELYLKRA....NFRGSHCEL...K...KAKFIEIG.FrKIPEVNMIGFLRGDRELPALVSE.......YRQIFDKMLSE...KFT..VVLLFGIERW.FIK..RNE.KIPF--..-VNVL..TSFL.GDTPRIAFYIVNRDILNIASPG.AFALLEDLATTIIEFKKGVR.R......KIV-ITKALNRELE-----dyeme........................................................
C6A399_THESM/1-167              ......ma-------------------.---.-.----..------.-...-------IVDFL...D....T.LYLYKAQL....ELAGEDTSF..lN...DVKVIKVG.G.RLNVGQVIERLRVKDEPIILAQE.......YTKILNSLVKE...GEV.aVVLVLGIEKF.API..LEL.EKVLT-..GINAL..LSFV.GDERRIMFYFINTDVLERAIPE.VLPLLEDIGTTVVRINVVEK.S......YTFSVVKTINRKILGLKV-t............................................................
Q8U187_PYRFU/8-207              ........DFVKDKLFGETVLVENNSY.LGV.E.TLLF..VIFKLG.E...ELNVPILVEDVL...D....T.FSIYKKHL....EMLGLKTP-...E...NIKILKIG.G.SEEGKGVVKRIPFDFDISRYLLE.......YGKSFEDVSPK...EKF..IDLVFGLDRF.FIL..IDN.LIDTAK..LLNSI..KNYI.HNENRTAFYFIEANLLKATKPI.ILYYLEDIATSVVRINQEKN.I......LTFEPVK----DIWS----vrnk.........................................................
C6A4N0_THESM/9-214              .......k-LVDKIKFGETVLVEYYHS.FIP.E.ITTL..GLLYYG.R...TRGLPVIIDDNF...D....F.LYIIQKHL....EFVGIDEDF...G...DALVVKTG.G.KRDVGNVVAKLKFSGEPIIYMRN.......YEESSKATFSK...VEK.sINIVLGLERL.FSF..VSS.ISEFYT..FVIAI..QSFL.GNEKRKSFYLVNKEIASSIPFN.PLPELERIASTVIEGVPTPT.S......GVFTFKKTTSLNLLGKKI-e............................................................
Q8TZT8_PYRFU/9-204              .......i-LLDEMRNGDVAIVEYSSS.SPI.H.RLVWgeIILKYV.D...RYE--FVIDDFFgigD...vM.FRTYLRRIsspdEYTKIMEKT...K...NIKAIKIGpG.KISYASKVEELPLTYNLSEFIKL.......YYPIIRDILAK...SSKrvFFITLGLSQY.LYL..GEA.K-ALET..-ILLS..RSVL.PIEDWTSIYFLNTDVAPEKA--.-VAALEEISPIVIQVRNNE-.-......-------------------ilvkki.......................................................
Q8U186_PYRFU/7-214              ........ELMDSIRFGETALIEYSSS.FIP.E.FALL..KIAEYA.R...AKNLPLIIDDNF...D....T.FPLIITHL....KVLGIREDI..lNs.kNVYVIKTG.G.KKKVGNVIAHIKDVEEPRIYIQE.......YKKGLQQLSNI...EKF..INVVLGLEKL.FMI..MKN.PLEVYL..SIMDI..QKYL.GNKKRKAFYIMNVNLLNSINPL.LKFEFERVASLIGEVRVVHS.T......AYVKILKCMNPRLVGNEI-t............................................................
C6A1H3_THESM/10-220             ......nq--LKKIRKGEDVLVEHTSS.EPI.H.LTFC..TIINYV.KqrkQRNTKVLLVDIL...D....Q.LHLLKAHL....ELAGIDSSF..iE...NLPVIKFG.G.IIKTGKILKRIELKSEISIWREQ.......YLEALKEFQREe.dNEF.gIRIVVGIEKL.IKL..YEDdPRALET.fFGTII..RPFL.GNEKRILVTLINTSLINEEI--.-LQEFREHSSRSFLVLLSER.K......IHFQVIKSIDFEDYGKT--fs...........................................................
#=GC seq_cons                   .........hhcsl+.GEsVLlEYsS..s.s.p.lhhh..tllpas.c...ccshslll-Dlh...D....T.Lalahp+L....chhGhcssh..hc...slpVIKhG.G.chplGsllp+lplpp-hslahpc.......Ypchhcclhpp...pcs..lslVLGl-+L.hhh..hps..tchhh..hlptl..psal.GscpRhuhYFlNpsllppt.....LshLE-luooVlclppptp.t......hhhplhKs.s.ph.s....t............................................................
//