#=GF ID   DUF2666
#=GF AC   PF10869.12
#=GF DE   Domain of unknown function (DUF2666) 
#=GF AU   Pollington J;0000-0002-8158-8998
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   PRODOM
#=GF GA   23.00 23.00;
#=GF TC   23.00 24.50;
#=GF NC   22.90 22.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   22616997
#=GF RT   Crystal structure of Pyrococcus furiosus PF2050, a member of the
#=GF RT   DUF2666 protein  family.
#=GF RA   Han BG, Jeong KC, Cho JW, Jeong BC, Song HK, Lee JY, Shin DH,
#=GF RA   Lee S, Lee BI;
#=GF RL   FEBS Lett. 2012;586:1384-1388.
#=GF DR   INTERPRO; IPR022620;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain found in archaeal proteins, including PF2050 from
#=GF CC   Pyrococcus furiosus (Swiss:Q8TZE5). PF2050, with an overall
#=GF CC   globular structure, contain this domain twice, each showing an
#=GF CC   antiparallel beta-sheet and an alpha-helical bundle, and shows a
#=GF CC   positively charged basic cleft on one side. This protein
#=GF CC   interacts with circular and linear dsDNA [1]. 
#=GF SQ   16
#=GS Q5JGL5_THEKO/4-123      AC Q5JGL5.1
#=GS F0LM38_THEBM/138-263    AC F0LM38.1
#=GS Y596_METJA/2-136        AC Q58013.1
#=GS F6BEN2_METIK/2-136      AC F6BEN2.1
#=GS A0A218NNJ7_9ARCH/6-135  AC A0A218NNJ7.1
#=GS Q5JGL5_THEKO/138-262    AC Q5JGL5.1
#=GS A6UU54_META3/2-136      AC A6UU54.1
#=GS C7DG34_MICA2/6-136      AC C7DG34.1
#=GS Q6M158_METMP/3-137      AC Q6M158.1
#=GS Q8TZE5_PYRFU/134-251    AC Q8TZE5.1
#=GS C6A0L1_THESM/138-263    AC C6A0L1.1
#=GS A0A8J7YAM0_9EURY/3-138  AC A0A8J7YAM0.1
#=GS Q8TZE5_PYRFU/3-118      AC Q8TZE5.1
#=GS D7DV69_METV3/3-137      AC D7DV69.1
#=GS F0LM38_THEBM/4-121      AC F0LM38.1
#=GS C6A0L1_THESM/4-124      AC C6A0L1.1
Q5JGL5_THEKO/4-123                 ..EEHVAFTAKHNDWRVAKKLT---ELEDENVAHFLAGIANSVNSRIPGYMgeKIDIDGIRKLAEEVR---K.-----DTLSDTIVALKSPGTSRKLGGL..VREnDKKL....KKL....LVDAAKAVLVRMTLEGV-------------vpinyp..
F0LM38_THEBM/138-263               ..EDHINFTAKHGSWIVVKRLIIDEKTELADVARLLASINETITSKLPIYA..EIDLKGIDEWFAGVKKAKS.----DVEIKTLVDKYLHFPAHR-----..YAP.SEFE....KHA....RIYALRKMLEKVGLSLDVPAKPLEKYLEK-k.......
Y596_METJA/2-136                   ..EDKIEFMAKHKKWFVVKKLKIDENTEDIEIARLLASIDETVLNKIPEYL..PFDMNKLYEIADGIYQKKK.GRITEEEIAEVLKKLKSPATTRKLNEI..TES.KEGK....EIL....KAILNNIILERLGIQTRVSPKVIEKYIENS........
F6BEN2_METIK/2-136                 ..ENRIQFIAKHNDWFVVKKMNIDDKTENIEIARLLSSIDETVLNKLPEYL..PFDMKKLEEIADEIYQKKK.GRVKEEDVVNALMKLKSPSTTKKLGEI..TDS.KEGK....EIL....KVILNNIILERLGIKTRVDPKLIEKYIEK-m.......
A0A218NNJ7_9ARCH/6-135             .d-NYIDFSVKYNDWVAIKRLSIDDKVTPEEVVYNLASIESSIDSKVYKFL..GIDINSIDSLAKNLAKQSG.--SGYKGLPKLASLIDTKQVKDSLSKA..CKT.QVVV....PFA....KSYLLDKSLKYMKLSADIE-----------lptmlkaf
Q5JGL5_THEKO/138-262               ..EDHVNFTAKHGKWIVVKRLIIDEKTPLLDVARLLASINETVTLKLPAYA..HIDVEGIEGEFSAFKKVKK.-----SDIPKVVEAYEAFEPSA-----..YAD.EPFL....EHA....RVYALRVALEKIGLPLDVPSKSLEKYLEKA........
A6UU54_META3/2-136                 ..EQSIQFRAKKGKWTVIKKINIDENTTDTEVARLLNSIDETVNKKVYEFL..PFDLDKIEEIANEIYEKKK.GKVKEEDITNALLKLKSPATTRKLNAI..TKS.KEGK....AIV....KIILNNIVLERLGIKTRLETKLIDKYMEKN........
C7DG34_MICA2/6-136                 ..EEYVEFMAKYKDWVSIKRMSIGPSTKPEEVVYHMAGIRSTIDGKAFKLL..GIDTEMLDAYAESSTRSA-.GR-GYSGLSKAVLIMESNDTKSIIEKA..CQS.QTMS....PFA....RSYLLNRIISAMKFETSVSQLGLSK-----vfp.....
Q6M158_METMP/3-137                 ..EERIQFNAKKGKWYVSKKIKIDENTSNEEIARVLASIEETLSIKIKDFL..PFDMEKLRAIADEIYEKKK.GRVKEEDISGALTKLKSPGTTKKLGTI..DDT.KEGK....EIL....KRLLTEIVLERLGITSKIEAKMIEKYIEKS........
Q8TZE5_PYRFU/134-251               ..EDHINFTARYGSWIVVKRMIIDEKTPLLDIARLLASINETAVNKIKDFA..DVDDKKIVEYFGGFKKVKK.----EEEIKEIVQLFREF---------..---.-KGN....EFE....VRYAAREMLSKLGLKVDVPSKNLEKYLEKA........
C6A0L1_THESM/138-263               .d-EHINFTAKNGSWIVVKRLIIDNKTPMADIARILASINETAVSKIPLYG..KIDLDGIRKWFGDIKKARS.----EAEIKTLVEKFFHIPVEN-----..YAP.NEFK....DHA....KIYALRVALEKVGLTIDIPAKPLEKYLEK-r.......
A0A8J7YAM0_9EURY/3-138             .n-ENIQFRVKKGKWFVAKKMEIDENTENIDIARMLISIDETLHKKILEHL..PFDIKKLEEIADDIYKKKRcGRAKEEDIVEALKKLKSPKTTKRLKEI..TEV.KEGL....EIL....KIVLNNIVLKRLGIKINLNTKLIDKYVEK-v.......
Q8TZE5_PYRFU/3-118                 er--ILEFTAKHEEWIVGENV---EDFTNENIAMFLSRVSNTVSSKIPGYLgeKIDVNGLL-------SIKI.----EGSLEEKLKALISPKVSRQIGRLvmEDD.KKLKkllvEVA....KAVLTREIL---------------------knelpief
D7DV69_METV3/3-137                 ..EEKITFNAKKGKWYVSKKLKIDEKTQDVEISRILISIEETLGKKIKDYL..PFDMIQLEEIADEIYVSKK.GRVKEEDISQALAKLKSPATTKKLGKL..TDL.KEGK....DIL....KVVLTNIILERLGIKTHIDVKTMDKFIEKS........
F0LM38_THEBM/4-121                 ..EEHVMFTAKHKNWKVGDKLLV---MRDENIAHFLASISNTVNMKISEYL..-IDVIDVAAVMSLAED---.--LAEGELWEVVKVLKSPKTSRKIGKMvfESD.KKLKkqlvDVA....KALLVRETLSR-------------------mlsvy...
C6A0L1_THESM/4-124                 ..EDHIAFTANHKNWKVGDKLLA---MDDRQIAHFLAMVSNTVTLKLPEYL..TE-VMNVAGIMS---LAE-.-EMTEKDVWELLKTLKSPGTSRKLNPMifEEN.KKLK....NHLlnvaKALLTREALSK-------------------kvsinype
#=GC seq_cons                      ..E-+IpFsAK+scWhVsK+lhID-pTpst-IARhLASIsETlspKl.cYL..shDlcplcplhstlhctKp....tEc-lscslptL+SPsTo+plsth..pcs.cchc....-hh....KshLschhLc+lGlphcl.sK.l-KahEp.h.......
//