#=GF ID   DUF4380
#=GF AC   PF14315.10
#=GF DE   Domain of unknown function (DUF4380)
#=GF AU   Eberhardt R;0000-0001-6152-1369
#=GF SE   Jackhmmer:Q7UYS3
#=GF GA   29.40 29.40;
#=GF TC   29.50 29.50;
#=GF NC   29.30 29.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR025488;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family of proteins is found in bacteria, archaea and
#=GF CC   eukaryotes.  Proteins in this family are typically between 288
#=GF CC   and 372 amino acids in length. There are two completely
#=GF CC   conserved residues (G and E) that may be functionally important.
#=GF SQ   110
#=GS A0A328UAH3_9BACL/16-298   AC A0A328UAH3.1
#=GS A0A1V8ZY29_SACPI/10-186   AC A0A1V8ZY29.1
#=GS A0A3N6GJJ7_9ACTN/19-319   AC A0A3N6GJJ7.1
#=GS A0A4Q5VE19_9GAMM/92-292   AC A0A4Q5VE19.1
#=GS A0A1G8Q8B2_9SPHI/12-317   AC A0A1G8Q8B2.1
#=GS A0A1H1PPR4_9FLAO/91-278   AC A0A1H1PPR4.1
#=GS A0A840QJG0_9PSEU/11-186   AC A0A840QJG0.1
#=GS A0A1Z4J2G5_9CYAN/43-313   AC A0A1Z4J2G5.1
#=GS A0A143HNW8_9GAMM/70-358   AC A0A143HNW8.1
#=GS K9D793_9BURK/32-318       AC K9D793.1
#=GS A0A1Q4RKY0_9CYAN/43-313   AC A0A1Q4RKY0.1
#=GS A0A4Q2KUZ2_9MICO/39-337   AC A0A4Q2KUZ2.1
#=GS A0A7G8WQP7_9ACTN/18-316   AC A0A7G8WQP7.1
#=GS A0A840ID86_9ACTN/15-317   AC A0A840ID86.1
#=GS A0A222VPK3_9PSEU/14-311   AC A0A222VPK3.1
#=GS A0A0M2PXQ1_PROHO/78-330   AC A0A0M2PXQ1.1
#=GS E6WUB2_PSEUU/31-324       AC E6WUB2.1
#=GS S0EU37_CHTCT/38-196       AC S0EU37.1
#=GS A0A1R3UIY6_9ACTN/15-312   AC A0A1R3UIY6.1
#=GS A0A6N4SWQ2_CYTH3/80-295   AC A0A6N4SWQ2.1
#=GS A0A374WDX9_9BACE/71-268   AC A0A374WDX9.1
#=GS A0A7X1E4M8_9BACT/26-321   AC A0A7X1E4M8.1
#=GS A0A1Y0FV11_9GAMM/48-299   AC A0A1Y0FV11.1
#=GS A0A2C6CND6_9BACT/58-313   AC A0A2C6CND6.1
#=GS A0A4Q5X2X3_9DELT/246-337  AC A0A4Q5X2X3.1
#=GS A0A1H8YJB5_9PSEU/5-291    AC A0A1H8YJB5.1
#=GS A6GIW0_9DELT/1-249        AC A6GIW0.1
#=GS A0A1Y6C4H5_9ALTE/21-315   AC A0A1Y6C4H5.1
#=GS A0A1W9QJC0_9DELT/122-377  AC A0A1W9QJC0.1
#=GS A0A853BJI3_9ACTN/16-313   AC A0A853BJI3.1
#=GS A0A7Z2ZTJ3_9BURK/32-336   AC A0A7Z2ZTJ3.1
#=GS A0A5C5U0U0_9GAMM/33-328   AC A0A5C5U0U0.1
#=GS A0A559QJZ9_9ALTE/24-321   AC A0A559QJZ9.1
#=GS A0A221W364_9PSEU/25-324   AC A0A221W364.1
#=GS A0A1Y0FUL9_9GAMM/29-324   AC A0A1Y0FUL9.1
#=GS A0A2T6FCX1_9GAMM/27-321   AC A0A2T6FCX1.1
#=GS A0A514BP14_9GAMM/24-316   AC A0A514BP14.1
#=GS A0A1H3JSC2_9PSEU/2-162    AC A0A1H3JSC2.1
#=GS B3PDI4_CELJU/33-239       AC B3PDI4.1
#=GS A0A316AB33_9BACT/20-320   AC A0A316AB33.1
#=GS A0A559QPC0_9ALTE/180-269  AC A0A559QPC0.1
#=GS A0A2S8SQJ3_9BACT/53-325   AC A0A2S8SQJ3.1
#=GS A0A8J2XDP6_9MICO/17-314   AC A0A8J2XDP6.1
#=GS A0A3B7MVC3_9BACT/68-282   AC A0A3B7MVC3.1
#=GS A0A1I3Q1P2_9PSEU/7-182    AC A0A1I3Q1P2.1
#=GS A0A7W7Q0P1_9PSEU/2-286    AC A0A7W7Q0P1.1
#=GS A0A7W7CFS5_9PSEU/3-291    AC A0A7W7CFS5.1
#=GS A0A542MF19_9BURK/25-313   AC A0A542MF19.1
#=GS A0A098LE53_9BACT/68-287   AC A0A098LE53.1
#=GS U5Q609_9BACT/39-273       AC U5Q609.1
#=GS A0A3N6X707_9ACTN/1-296    AC A0A3N6X707.1
#=GS A0A1H1G957_9GAMM/19-313   AC A0A1H1G957.1
#=GS Q21L48_SACD2/136-242      AC Q21L48.1
#=GS A0A1S9AM83_9BURK/27-317   AC A0A1S9AM83.1
#=GS A0A4Q5NP16_9BACT/91-337   AC A0A4Q5NP16.1
#=GS A0A1A9I6T2_9BACT/117-293  AC A0A1A9I6T2.1
#=GS D9WIT1_9ACTN/25-325       AC D9WIT1.1
#=GS C5BMK8_TERTT/54-250       AC C5BMK8.1
#=GS E5CAR9_9BACE/100-280      AC E5CAR9.2
#=GS A0A853B7Z9_9PSEU/2-169    AC A0A853B7Z9.1
#=GS Q5H6C8_XANOR/75-369       AC Q5H6C8.1
#=GS A0QZF1_MYCS2/19-306       AC A0QZF1.1
#=GS A0A6G4V4L6_9ACTN/27-326   AC A0A6G4V4L6.1
#=GS A0A1G7IZY1_9FLAO/1-247    AC A0A1G7IZY1.1
#=GS A0A519W6A1_9SPHI/12-314   AC A0A519W6A1.1
#=GS A0A410PP29_9CLOT/16-299   AC A0A410PP29.1
#=GS A0A1G9TTQ2_9SPHI/69-286   AC A0A1G9TTQ2.1
#=GS Q8P3C5_XANCP/43-337       AC Q8P3C5.1
#=GS B3PL34_CELJU/26-320       AC B3PL34.1
#=GS A0A7W4ZAE6_9GAMM/29-318   AC A0A7W4ZAE6.1
#=GS A0A318MB75_9PSEU/10-300   AC A0A318MB75.1
#=GS A0A4R7US82_9PSEU/1-280    AC A0A4R7US82.1
#=GS A0A374W839_9BACE/80-275   AC A0A374W839.1
#=GS A0A1U9N6K6_9GAMM/28-322   AC A0A1U9N6K6.1
#=GS A0A1W1XMN9_9CLOT/12-294   AC A0A1W1XMN9.1
#=GS A0A7G9SMU6_9GAMM/32-327   AC A0A7G9SMU6.1
#=GS A0A2H5ZJ64_9BACT/87-296   AC A0A2H5ZJ64.1
#=GS A0A1B1G2G5_9BACT/70-284   AC A0A1B1G2G5.1
#=GS A0A4P6Q0T3_9ACTN/12-308   AC A0A4P6Q0T3.1
#=GS A0A369BG12_9FIRM/79-280   AC A0A369BG12.1
#=GS A0A286D8F3_9GAMM/19-313   AC A0A286D8F3.1
#=GS K9RCR4_9CYAN/49-317       AC K9RCR4.1
#=GS A0A098UFI2_9BURK/26-319   AC A0A098UFI2.1
#=GS A0A562CA79_9GAMM/39-332   AC A0A562CA79.1
#=GS A0A5N8XCV9_9ACTN/26-325   AC A0A5N8XCV9.1
#=GS A0A3M0G9X7_9ACTN/5-302    AC A0A3M0G9X7.1
#=GS A0A368TC73_9ACTN/15-312   AC A0A368TC73.1
#=GS A0A1Y6BG64_9ALTE/51-247   AC A0A1Y6BG64.1
#=GS A0A429FZP6_9ACTN/13-199   AC A0A429FZP6.1
#=GS Q21JR3_SACD2/57-345       AC Q21JR3.1
#=GS A0A0R0ALK8_9GAMM/1-293    AC A0A0R0ALK8.1
#=GS A0A4V5PQ87_9DELT/109-332  AC A0A4V5PQ87.1
#=GS C5BPK4_TERTT/57-354       AC C5BPK4.1
#=GS A0A3R9XML8_9ACTN/19-321   AC A0A3R9XML8.1
#=GS A0A1Q2M390_9GAMM/71-274   AC A0A1Q2M390.1
#=GS A0A7V8GPC4_9GAMM/30-326   AC A0A7V8GPC4.1
#=GS A0A402CR28_9BACT/54-337   AC A0A402CR28.1
#=GS A0A0E3ULR8_9GAMM/32-327   AC A0A0E3ULR8.1
#=GS A0A5M3XNW4_9ACTN/1-302    AC A0A5M3XNW4.1
#=GS A0A1N7DQE3_9ACTN/7-308    AC A0A1N7DQE3.1
#=GS A0A2V4AZR5_9PSEU/13-185   AC A0A2V4AZR5.1
#=GS B8CXN3_HALOH/13-294       AC B8CXN3.1
#=GS A0A1W6LJQ8_9BACT/28-332   AC A0A1W6LJQ8.1
#=GS A0A7X0HAU5_9BACT/49-321   AC A0A7X0HAU5.1
#=GS A0A1C0ABH3_9FIRM/13-294   AC A0A1C0ABH3.1
#=GS A0A1M6UDC2_9ACTN/14-313   AC A0A1M6UDC2.1
#=GS A0A848FW07_9BACT/31-282   AC A0A848FW07.1
#=GS A0A239HEA2_9BACT/83-285   AC A0A239HEA2.1
#=GS A0A1I4Y0U9_9ACTN/23-315   AC A0A1I4Y0U9.1
#=GS A0A1I6TLZ6_9PSEU/13-301   AC A0A1I6TLZ6.1
A0A328UAH3_9BACL/16-298              ................................................................ps---ITIRTAFYELTVLPAIGGRIIGFG.LD....GV-..NLLY....QNDS.LEghcphyepagS...E....GM.......Q....S......IR.K..S.S..P.I....L.L....YG...GEKTWLAPQ.SDWGGTPYA.DLD--------..-.-.-.-HG...EY....A....C....E...I...L...R...G....E...R..T.F...R.LTLTSPICRE.TG..IQLIRTLTF-EQDV..R...YVDIEQR......MI.NRSSV..QVTKGF..WQVTM....L.....N.......RN....G........T......VHI..PQg..lAL.K...E.E.A...S....IP.L-.-.L....NAQ..NASVQRSAD.G.W....tMP.VD.N....-......--.......-..........GLM..YKLG.FMTDggR..ASA.V....YE.A..DN..G..K..TYE...LTKTFQV.E....P....DR-....KYPH.GT.V....VEV...Y..............N--.........-.....--.........A.........S.........EY.........S.........Y.........YELEVHSPAYTLNPGEDAA.FTIRWEL-a......................................................................................................................................
A0A1V8ZY29_SACPI/10-186              ................................................................tv---VWLSNDRLRLGIVPELGGRLLSLS.RQ....DGR..ELLW....RDEN.LL..........T...D....EL.......Rf..rD......GH.V..H.R..P.V....A.G....SL...GDWVNYGGD.KTWPAPQGW.ES--RDQWA-G..P.P.D.PVLdsgAY....A....V....T...T...D...V...R....D...G..L.A...T.VTLTSGDDPR.TG..LRLRRRFEL-RDGG..D...GYRLTLS......AL.NTSGR..SVRWAL..WNVTQ....L.....A.......AD....G........-......---..--....--.-...-.-.-...-....--.--.-.-....---..---------.-.-.....--.--.-....-......--.......-..........---..----.----..-..---.-....--.-..--..-..-..---...-------.-....-....---....----.--.-....---...-..............---.........-.....--.........-.........-.........--.........-.........-.........-------------------.--------eggtlvggperv...........................................................................................................................
A0A3N6GJJ7_9ACTN/19-319              ................................................................el---ITLDAGALTVTAAPGLGGRLLSVT.LG....GSE..FLYR....NPRL.LD..........Dd.lT....PL.......P....G......VR.A..G.P..H.D....G.P....MA...DWLNWGGD-.KTWPAPQGW.DGPGQ-----WagP.P.D.PVL...DS....Gp..yT....A...R...V...E...Q....R...D..G.T..aA.LVLTSGEDPR.TG..LRLERRIVL-RPRS..T...AFGLHLT......MT.NTSAV..ERRWAL..WNVTQ....I.....A.......GA....P........P......A--..SP....AG.A...E.G.V...Y....LG.RA.R.S....GRP..STVPLVAGT.G.R....pQV.LE.A....A......ADv....lyV..........PHQ..DVVG.KVGF..P..DSA.G....WL.A..HV..G..P..ERT...LAQGFTI.RegsyPdegsRAE....VWME.CP.L....TEG...L..............PHL.........G.....GL.........R.........P.........RD.........H.........V.........VECEVLGPLTTLAPGASA-.--------alevef.................................................................................................................................
A0A4Q5VE19_9GAMM/92-292              ............................................................spqsew---------------------------.--....---..----....----.--..........-...-....--.......-....-......--.-..-.-..-.-....-.-....--...---------.---------.---------GW..P.P.I.DVL...DS....A....P....Y...E...V...S...V....-...V..E.N...R.IIFTSKIDPR.TG..YKFVKSYGL-NPEK..K...CISIIYS......IY.NHSNV..DKNVAA..WEVTR....F.....N.......PK....G........M......AFF..PQ....GN.T...E.-.-...-....--.--.S.N....SGI..FYPLAVEHI.G.D.....LT.WA.K....Y......EP.......E..........YLL..QNHH.KLMT..D..GKE.G....WV.A..YT..T..A..GKL...LIKEFAD.V....P....VEL....IVSG.EG.E....IDL...F..............AN-.........-.....--.........-.........F.........EK.........T.........F.........WEIAQQGVMTKLAPGEHLD.WEVRWH--tr.....................................................................................................................................
A0A1G8Q8B2_9SPHI/12-317              ................................................................dv---IALKNKWMTVCVAPNLGGRIIQLG.LM....EEE..LLFN...nVNLH.GV..........D...I....AS.......A....G......FK.E..K.T..N.W....L.N....FG...GEKIWPAPQ.G-WDSEQQW.-PG---PPDVI..L.D.G.GFY...SV....S....T....D...N...S...D...S....T...A..G.D...Q.VSLKSDVDPY.TG..LQILKDITL-SEDS..S...KILVKAT......FI.NKSNK..AKVWSI..WPVIQ....L.....D.......TP....D........I......TTI..DR...yKI.I...C.P.L...N....PK.SK.F.K....DGF..QVMHGLVNS.P.Q.....YK.VN.S....S......GNf.....qV..........TNQ..YLVG.KVGL..D..ADA.N....WV.A..FC..D..KkiGNV...LIATFEY.D....-....KKA....IYPE.DT.S....VQI...W..............VQG.........K.....--.........-.........-.........--.........-.........-.........-------------------.--------glvysrnrvneyfedpsknfpymeiellsplcemqpdsqmtfeyqmll.......................................................................................
A0A1H1PPR4_9FLAO/91-278              ............................................................tgsrhi---------------------------.--....---..----....----.--..........-...-....--.......-....-......--.-..-.-..-.-....-.-....--...---------.---------.-----------..-.P.D.PYI...NA....S....S....Y...S...V...-...T....L...L..K.N...G.VVLKSPVSDL.LG..IQINRTITISEK-G..T...QVHINQElikkklAK.NIDLE..KIPLTI..WSLSK....I.....K.......TP....N........I......CYT..PI....SD.N...S.K.F...KdgftIS.KW.P.D....SKN.nAEENVAVKN.G.V.....LS.LK.S....-......-S.......K..........DLP..QKIG.---L..-..DAK.N....WV.A..GY..L..N..DTL...FIEKFNF.D....D....RA-....----.--.-....---...-..............---.........-.....--.........-.........-.........--.........-.........-.........-------------------.--------typdngtsvtifgnhlftelecls...............................................................................................................
A0A840QJG0_9PSEU/11-186              ...............................................................vww-----LANDGLRLGIVPELGGRLLSLS.GK....DGR..ELLW....RNDD.LL..........T...D....DL.......R....F......RD.GhlH.R..P.V....S.G....GL...GDWVNYGGD.KTWPAPQGW.AGAD---QWAG..P.P.D.PVL...DS....G....A....Y...T...V...T...Te.erA...D..A.A...V.VTLTSGDEPR.TG..LRLGRRFEL-RRGE..S...AYRLTLS......AR.NTSDR..DVRWAL..WNVTQ....L.....A.......AD....G........-......---..--....--.-...-.-.-...-....--.--.-.-....---..---------.-.-.....--.--.-....-......--.......-..........---..----.----..-..---.-....--.-..--..-..-..---...-------.-....-....---....----.--.-....---...-..............---.........-.....--.........-.........-.........--.........-.........-.........-------------------.--------eggtlvggpehv...........................................................................................................................
A0A1Z4J2G5_9CYAN/43-313              ..............................................................dsyi-----LSNGQVEAVVVPKV-GRIMQFR.FK....GGE..GPFW....ENPQ.VY..........G...-....KA.......P....N......VK.S..K.-..-.E....W.G....YFgagGDKTWPAPQ.SEWEKI---.------TGRGW..P.PpA.TFD...SI....A....V....T...A...R...V...N....-...-..R.S...E.VTLISAIDPF.YG..IRFYRKITL-EPKK..P...VMRVTTT......YE.KVKGK..SKDVSV..WIVTQ....L.....R.......DP....V........A......VYT..AL....PQ.T...S.I.F...P....EG.YN.K.Q....SED..LPANLKVDN.G.L.....LS.LT.R....D......RN.......K..........SH-..----.K--I..G..CDA.S....TL.L..WM..D..E..KVA...VRIDSPR.V....S....GAS....YPDN.NS.S....AEI...Y..............TNL.........D.....PK.........A.........-.........--.........-.........Y.........VELEFLSTLKTLRVGEKMD.LTTTYT--li.....................................................................................................................................
A0A143HNW8_9GAMM/70-358              ...............................................................eiy----KLQNSKLSYSFTPQIGGRGLAFS.AA....GEK..NLLK....VGTA.VQ..........E...Q....PN.......P....D......IS.P..Q.A..G.F....I.P....YQ...GHIIWPGPQ.ADWWKQQEV.NPQRRAAGAVW..P.P.D.PFT...VL....N....D....Y...E...L...T...A....V...S..D.K...S.ATIVSPVSPV.TG..LQLTKEFTL---KD..D...VLLHRVT......AV.NRRET..PVKWDI..WFNTR....V.....S.......PE....T........R......VYV..PI....ADfS...R.D.L...R....LE.KF.P.E....MTTevKADAEKQRL.G.L.....FG.FA.R....-......--.......-..........-GE..NIKA.KAFI..E..PSA.G....WI.A..AF..T..Q..GQL...FVIEFPR.Q....A....RDS....IHPD.QG.Q....VEL...Y..............LEQ.........D.....PQ.........N.........P.........DA.........G.........V.........LELEVHAPYRELAPGESMS.ATETWRA-l......................................................................................................................................
K9D793_9BURK/32-318                  ...............................................................psh----RLDNGVVQARIAEPAGGRLLSFA.LA....GKP..NFLL....VDET.AG..........-...A....PD.......A....I......PN.A..A.S..G.H....V.P....YQ...GHEVWIGPQ.SEWWVHQDV.NPARAAAQAAW..P.P.D.PWL...SL....A....T....Y...T...L...V...E....H...K..R.D...E.IVLDSPASPV.SG..IQLRKRYALVADKP..H...SLRLEAE......AT.NRSGK..QAGRDI..WFNTR....V.....P.......AH....T........M......AYV..PV....AA.P...D.D.V...R....IE.PA.-.-....---..GALRYTLAG.G.L.....LS.LD.L....-......PA.......P..........GDP..ARKG.KLFV..Q..PSS.G....WL.A..AF..R..D..GQL...LVIQFAH.Q....P....RAA....IHPA.QG.Q....VEL...Y..............QDI.........D.....PR.........A.........A.........DK.........G.........M.........LELEVHAPYVRLAPGEAMR.ASELWTIL.......................................................................................................................................
A0A1Q4RKY0_9CYAN/43-313              ..............................................................dsyi-----LSNGQVEAVVVPKV-GRVMQFR.FK....GGE..GTFW....ENDQ.VY..........G...-....KA.......P....N......IK.S..K.-..-.E....W.G....YFgagGDKTWPAPQ.SAWEKI---.------TGRGW..P.P.PaTFD...SI....P....V....T...A...-...-...R....V...N..R.N...D.VTLISPIDPF.YG..IRTFRTITL-EQHK..P...VMKITTT......YE.KVKGK..PQNVSI..WIVTQ....L.....R.......DP....V........A......AYA..AL....PQ.P...S.I.F...P....EG.YN.K.Q....SEN..LPANLKVDN.G.L.....LS.LT.R....D......RN.......K..........S--..---H.K--I..G..CDA.S....TL.L..WM..G..E..KVA...VRIDSPR.V....P....GAS....YPDN.NS.S....AEI...Y..............TNL.........D.....PK.........A.........-.........--.........-.........Y.........VELEFLSPLKTLRVGEKMD.FTTTYTL-i......................................................................................................................................
A0A4Q2KUZ2_9MICO/39-337              ...............................................................iyr-----VDNGTVALAFLPTVGGRLISVA.AH....GRE..LLWR....NPEY.LD..........A...S....LQ.......Av..rR......RS.D..W.P..R.H....D.G....TF...ASWVNIGGS.KTWPAPQGW.NGEGEWAG---..P.P.D.PVL...DS....G....A....W...S...I...E...S....R...E..S.DdglV.VIMTSADDPR.TG..VRITKEFTVPGSGP..E...F-AQQTT......FT.NISYQ..TVTWAV..WEVAQ....I.....D.......TE....G.......gG......VHA..EV...eVD.V...T.D.T...R....VV.DL.G.S....YHG..-TFEVEHGE.G.T.....VS.AG.I....-......--.......Q..........DVV..VKRG.----..F..PSAsG....RI.A..YY..E..D..TGV...-GLELSF.S....P...iVDA....IYPD.QGsR....AEL...W..............MQApipaplaelD.....GL.........H.........P.........DA.........W.........L.........AELEVLSPLTTMRPGESVS.FEIGWR--al.....................................................................................................................................
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A0A0M2PXQ1_PROHO/78-330              ...........................................................gryrlsl--------DTVTVEVDAQQGGRIIAFA.LD....G-E..NLLR....DNS-.--..........-...-....VD.......P....Q......--.-..-.-..-.N....-.-....-Y...GSTFWVSPQ.AIW------.---------DW..P.P.V.PEI...DR....A....P....Y...Q...V...L...Q....-...S..D.R...S.LRLVSQPSPS.LG..IQVSKSLALGRFRA..DgspTLRLTYR......IT.NTHTH..PLRYAP..WEVSR....V.....S.......PT....G........V......TFY..PT....GS.A...L.-.-...-....--.-Y.G.S....GSF..GTPLTETSA.G.V.....TW.WN.H....D......SA.......P..........LSQ..--DQ.KLFA..E..GFG.G....WL.A..HL..D..G..DKL...FLKTFPD.I....T....AAD....QAPR.ES.E....IEV...Y..............AN-.........-.....--.........-.........G.........NH.........T.........Y.........VEMEAQGAYTRLAPGESLE.WTVGWSV-h......................................................................................................................................
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A0A1W9QJC0_9DELT/122-377             ............................................vtftwpertlvvdgtrgarvvs---------------------------.--....---..--LK....AGGN.EF..........L...S....QA.......P....S......AS.P..S.G..D.D....L.F....KY...GSTFWTSPQ.SAW------.---------GW..P.P.I.VAI...DS....A....A....Y...T...V...T...V....D...D..G.T...A.TFTSSNATVA.EGkdVRIKKAFSV-DTAK..D...VITIVYT......IE.NVGAG..SASFAP..WEITR....V.....P.......KS....G........L......TFF..PT....GE.S...A.-.-...-....--.-S.T.P....EGM..GMLPVTNAG.G.I.....TW.FQ.H....P......GM.......A..........VEE..D--R.KIHA..D..GKE.G....WL.A..HA..T..P..TVT...LIKSFAD.L....Q....SGQ....AAPT.EG.E....VEI...Y..............SAK.........D.....--.........-.........-.........-G.........T.........Y.........VEVENQGAYKDLAAGASLT.YEVRWLL-r......................................................................................................................................
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A0A5M3XNW4_9ACTN/1-302               .................................................................m---IQLVSPWIRAVVLPGLGGRMISLH.AG....GRE..WLWR....NPEL.LD..........A...A....FS.......-....L......TD.A..A.A..R.Lp.apT.G....FS...SWANW-GGD.KTWPAPQGW.ASDQ---EWAG..P.P.D.PVL...DA....G....A....Y...T...V...L...E....R...T..E.L...R.VRMRSGDDPR.TG..LAITRTITL-ARDE..A...TIVVDSE......LE.NVSDR..PVRWAA..WTVTQ....F.....E.......TE....S........F......-QA..HG....DD.R...S.G.V...W....IG.LT.E.R....H-R..APVTLFAPD.G.A.....PA.LE.R....V......SPgl...grV..........PVR..DVVG.KIGV..G..GTA.G....WL.A..VV..A..P..GGI...TLTQRFD.V....R....EGA....AYPD.GGsE....IAI...W..............MQY.........P.....TD.........DdldgldglrP.........TA.........R.........L.........VEAETMSPLTRLTPGEVLH.HRVTWSL-t......................................................................................................................................
A0A1N7DQE3_9ACTN/7-308               ...............................................................vvr-----LAAPWGEAAVLPGRGGRIISLR.AA....GRE..WLWR....NPEL.LD..........A...S....LAi.....tP....A......AR.R..L.P..A.P....T.G....FA...SWANWGGD-.KTWPAPQGW.SSAQ---EWAG..P.P.D.PVL...DA....G....A....Y...T...V...L...E....R...D..D.L...R.LRMRSGDDPR.TG..LAVTRTVTM-SAAE..A...VLVVDSE......LE.NVTDH..PVRWAA..WTVSQ....F.....E.......TE....S........-......-FR..GH....DDpR...C.G.V...W....VG.-L.T.D....RHL..APVTLFAPD.G.A.....PV.LE.R....V......SLsa...grV..........PVR..DVVG.KIGI..G..GTA.G....WL.A..VT..A..P.gGAT...LTQRFDV.R....P....GAP....YPDE.GS.E....IAI...W..............MQY.........P.....KE.........E.........E.........LA.........GleglrptarL.........VEAETMSPLTSLAPGEVLR.HRVTWSV-t......................................................................................................................................
A0A2V4AZR5_9PSEU/13-185              ................................................................dv---LWLDNGVLRLGLVPALGGRLLSLR.RVs.ggDAR..ELLW....RNDR.LL.........tA...E....LT.......P....R......PG.H..E.P..RpH....A.G....SL...GDWANYGGD.KTWPAPQGW.DS-----DAQWagP.P.D.PVL...DS....G....P....Y...T...A...EpeqT....P...D..L.A...A.VTLTSGADPR.TG..LRLSRRFELRPGQC..-...GYRLRLT......AV.NTSER..TVRWAL..WNVTQ....L.....A.......AD....-........-......---..--....--.-...-.-.-...-....--.--.-.-....---..---------.-.-.....--.--.-....-......--.......-..........---..----.----..-..---.-....--.-..--..-..-..---...-------.-....-....---....----.--.-....---...-..............---.........-.....--.........-.........-.........--.........-.........-.........-------------------.--------gpggty.................................................................................................................................
B8CXN3_HALOH/13-294                  ...............................................................qgy----ELKNKVISLILLPEVGGKIVSFS.YR....GQD..LFFN....LPEN.ST..........S...KidlsRI.......G....D......VK.S..Y.R..K.K....F.D....YVptgGYKTWLAPQ.SKW------.---------DW..P.P.Y.LDL...EL....G....S....Y...N...MsvfQ...E....K...D..K.I...Q.VELTSPVCRE.SG..MRLMRVITLKAGSP..-...EVTIKQG......ME.NCSTT..DRTFGL..WDVTQ....I.....H.......GE....G........R......VIF..PI....LS.D...D.S.L...G...yIV.TP.E.K....NNY..-TERYNFDG.K.S.....FI.-S.V....H......CP.......G..........QEI..F---.KLGT..G..YSK.G....WI.L..TL..V..E..KED...WLLGYLK.-....-....---....IFPV.FS.G....ARFghgY..............AME.........V.....FD.........T.........N.........KY.........N.........Y.........FEVEVHGPLNKIRPQDKYF.FTEEWRVL.......................................................................................................................................
A0A1W6LJQ8_9BACT/28-332              ...............................................................cky-----LSNDLIDLKLVPEIGGRVLQYK.LG....D-Y..GFYY....VNKD.LY..........D...K....KP.......P....As....gLG.P..E.N..S.W....L.N....YG...GDKLWLAPQ.G--WSNEK-.---------QWpgP.P.D.PVL...DG....Q....P....Y...K...I...E...I....I...N..N.K...K.VRLTSREDLR.SG..VKLSRTIEI-FDGT..T...RVSIDAT......MK.NIDTK..TRRWGI..WAHTQ....F.....Y.......AG....N........R......HGK..GY....NK.N...-.Y.W...A....YC.PI.N.E....NSI..FQKGYGVQY.G.L.....VNnIS.Y....K......PDydkgimkV..........HYQ..RRVG.KIGL..D..SAA.G....WT.A..TVdgT..D..GYV...FIQRFTY.K....P....EK-....TYPD.NS.S....VEI...W..............MDG.........L.....GE.........F.........V.........AW.........G.........-.........-------------------.--------einritnddpsvtpynfenelispyatlkpseeysfhydwys.............................................................................................
A0A7X0HAU5_9BACT/49-321              ................................................................da---VKIDNGVVRLAVSPSV-GRVVEFG.YV....GQP..NLLW....VNTQ.DI..........F...D....TP.......P....G......-P.D..T.Y..Y.N....I.-....-G...GDKLWVAPQ.PLWKNA---.-----FGHDNW..P.P.E.GVI...DG....A....A....W...T...L...V...E....Q...K..R.D...S.ITIQSPESPD.YG..VVVRRTFQLPA-SK..S...QAVITNQ......IV.RLRAN..PHPLQL..WTVTQ....I.....K......ePD....T........A......VL-..DI....AK.D...-.G.P...E....MP.TP.F.V....KMT..DETPVKV-E.G.Y.....VR.LI.G....E......GG.......A..........VAW..TQQG.DVHA..KlgTLG.R....WV.A..GV..Y..D..GVV...FR-QSTK.F....D....ANA....AYPE.AS.S....VQV...Y..............RA-.........-.....G-.........-.........-.........--.........D.........Y.........TELELLSPLIQLAPGESMS.NTVTWAL-i......................................................................................................................................
A0A1C0ABH3_9FIRM/13-294              ...............................................................eay----RLENKYLSIVILPKVGGRIISFS.NK....EDE..ILYTapnlQGMT.LD..........L...L....EI.......D....N......IK.E..Y.R..E.K....I.K....YIalgGYKTWLSPQ.SNW------.---------DW..P.P.Y.LDL...EL....G....S....Y...K...C...T...Y....H...H..S.EdkiK.VNLISPICRE.SK..MQLTRTIVL-ERDS..Y...SLKIGQG......MK.NCSLE..NKECGL..WDVTQ....I.....A.......DN....G........Q......VIL..PI....SS.F...K.K.I...K....NL.ID.T.D....GTE..GIKVLEVNE.E.L.....YA.II.N....-......CF.......G..........DKM..FKIG.TD--..-..FSA.G....WV.L..AI.iD..K..GDKrlgYLKRFPI.F....E....GAN....F-GH.GC.A....VEI...F..............-DI.........-.....--.........-.........S.........NF.........N.........Y.........FEIEVHGPLSELLPEEEYG.FVEEWEL-y......................................................................................................................................
A0A1M6UDC2_9ACTN/14-313              .................................................................g-ERIVLDNGTVRLTAAPGLGGRLLSVR.LR....GRE..HLYR....NPRL.LD..........Ad.lR....AV.......P....G......VE.L..G.P..V.D....G.P....-M...SAWNNVGGD.KTWPAPQGW.DGPGQWA---G..P.P.D.PVL...DSgayaA....E....A...S...S...A...A....D...G..S.A...V.LTLTSGDDPR.SG..LRLRRRITL-EPGT..A...GFRLDLE......AV.NTSGT..ARRWAL..WNVTQ....I.....D.......GS....-........-......---..--....--.-...-.-.-...-....--.--.-.-....---..---------.-.-.....--.--.-....-......--.......-..........---..----.----..-..---.-....--.-..--..-..-..---...-------.-....-....---....----.--.-....---...-..............---.........-.....--.........-.........-.........--.........-.........-.........-------------------.--------gaagdaggvyagvrgpgphtvplvagngnprvlehapgvlrvpaqdvvgkvgfptasgwlahvgaagtltqrfavaeggaypdsgsraevwleapvdrplehlgglcpvdrvtevealgpladlapgqatrlave
A0A848FW07_9BACT/31-282              ...........ryelscmqgqsmgiapdkggrithltidgsnfltdstvnsdnwgstfwpspqsdw---------------------------.--....---..----....----.--..........-...-....--.......-....-......--.-..-.-..-.-....-.-....--...---------.---------.---------NW..P.P.P.A-A...WD....N....Q....P...Y...A...V...K....T...E..E.H...K.IIMESTPDRN.TG..LSVTKIFSA-DVQH..G...WYNLTYI......IA.NHSAV..VKHVAP..WEVTR....V.....H.......TN....G........F......SFF..PM....GK.G...A.-.L...R....GG.L-.-.-....---..-IPQTKIID.G.V.....CW.FT.Y....N......QQ.......Q..........IPD..KGDM.QLYA..D..GSE.G....WF.A..EV..N..H..GFI...LIKKFPD.I....P....FEK....LAPQ.EG.E....VEL...Y..............AN-.........-.....KD.........R.........Q.........EK.........S.........Y.........VEIEHQGAFTELPPGKSCV.WNMQWML-r......................................................................................................................................
A0A239HEA2_9BACT/83-285              ..........................................................pspqgawg---------------------------.--....---..----....----.--..........-...-....--.......-....-......--.-..-.-..-.-....-.-....--...---------.---------.----------W..P.P.-.SYP...LD....A....A....P...Y...T...A...T....V...P..D.K...V.LRMVSRRDEK.LG..WQFEKDITL-LPED..T...AVSITYT......IR.NIADT..VQQVAP..WQNSR....I.....E.......KK....G........L......VFF..PK....GK.Q...P.L.T...Q....--.--.-.G....QHF..KTVPVQEKD.G.I.....VW.LS.L....Q......--.......P..........DML..SEGE.KLIT..D..GAE.G....WL.A..YA..N..D..GLL...LVKQFED.V....A....PQQ....QAPG.EG.D....VEI...Y..............VAK.........S.....GA.........N.........-.........--.........-.........F.........TEIEPQGPYQTLQPGEELT.WTVKWYV-r......................................................................................................................................
A0A1I4Y0U9_9ACTN/23-315              ................................................................ev---VWLDNGTLRLGIVPALGGRLLSLV.RD....GEE..LLWR....NPAL.LD..........G...R....LH.......P....V......GG.H..RpE..R.T....S.G....PM...ANWRNYGGD.KTWPAPQGW.SSPGEWA---G..P.P.D.PVL...DS....G....P....Y...E...A...E...Vg.pgS...G..D.A...T.VALESEHDPR.TG..LRLRREIRLR-AGE..A...GYDLRVS......AV.NASSV..PVRWAV..WNVTQ....Y.....P.......GG....G........T......VQV..AV....EP.G...F.R.E...P....VE.LA.V.G....TAA..--PAWTRPR.-.-.....--.-P.D....T......VE.......V..........PAQ..DTVG.KLGF..P..HAA.G....RL.A..YS..R..A..GHH...LTMEFDV.H....P....DAP....YPDG.GS.R....AEV...W..............MEH.........P.....LD.........R.........P.........LE.........H.........LgglappariVECEALGPWETLAPGAAT-.--------alavrv.................................................................................................................................
A0A1I6TLZ6_9PSEU/13-301              ................................................................ev---LWLGNGLLTLGLVPRLGGRLLSLSgAD....GRE..QLWR....NDEL.LT..........S...D....LV.......P....R......RE.H..-.R..P.H....S.G....EL...GDWVNYGGD.KTWPAPQGW.E-----HSAQWagP.P.D.PVL...DS....G....R....Y...E...P...E...I....EvgeD..L.A...V.VTLTSGDDPR.TG..LRFARRFEL-RRGR..C...SYRLELT......AI.NTSQR..DVRWSL..WNVTQ....L.....A.......GD....G........A......GGT..YV....SS.A...A.E.V...T....--.-D.L.L....AGT..GYPKWTAED.G.R.....VH.VP.-....-......--.......-..........-HQ..DVVG.KLGF..P..AAE.G....WL.A..HV..G..P..GAT...LTQSFAV.D....R....EAE....YPDG.GS.R....VEV...W..............MEH.........P.....LPeplaalgdlD.........P.........PA.........R.........I.........VECEVLGPLTALAPGERTT.--------ltld...................................................................................................................................
#=GC seq_cons                        .................................................................h.....LpsshlphthsPtlGGRllpht.h.....st....hhh.....st..h...........t...t.............s...........ht....t...........h.s.....h...ut.h..usp.ppW...p.............W..P.P.D.PhL...st....u....s....h...p...s...h...p....p...s..s.s...p.lslpSsssPh.oG..lplp+phsL..tps..s...shplphs......hp.Nhssp..slpaul..WplTp....l.....s.......ss....s........t......sah..sl....ss.t...t.t.h........ht......t....tth...s..hphts.G.h.....h..ht.................................s.t..thhG.Klhh..s..sss.G....Wl.A..th..t..s..sth...hlhpFsh......s....tst....hhPp.pu.p....lEl...a..............hph...............................................t.........t.........h.........lEhEshuPhppLtPGtphp.ht..W...h......................................................................................................................................
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