#=GF ID   DUF4443
#=GF AC   PF14544.10
#=GF DE   Domain of unknown function (DUF4443)
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   CATH:2p8tA02
#=GF GA   27.00 27.00;
#=GF TC   27.50 31.90;
#=GF NC   26.90 26.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Domain_of_unknown_function
#=GF CL   CL0250
#=GF DR   INTERPRO; IPR029349;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is a family of archaeal proteins. The domain is a putative
#=GF CC   gyrase domain.
#=GF SQ   88
#=GS A0A0X8UZR3_THEX5/93-189   AC A0A0X8UZR3.1
#=GS A0A0X8V292_THEX5/105-202  AC A0A0X8V292.1
#=GS Q5JDB2_THEKO/86-187       AC Q5JDB2.1
#=GS A0A6A7LE78_9ARCH/105-205  AC A0A6A7LE78.1
#=GS M9SHY7_METAX/72-170       AC M9SHY7.1
#=GS A0A7L9FFM4_9CREN/86-186   AC A0A7L9FFM4.1
#=GS A0A0A7LDW2_9ARCH/117-213  AC A0A0A7LDW2.1
#=GS A0A087S7U8_9ARCH/67-166   AC A0A087S7U8.1
#=GS A0A2H5UWV9_9ARCH/108-206  AC A0A2H5UWV9.1
#=GS A0A133VD29_9EURY/91-136   AC A0A133VD29.1
#=GS A0A1D2R468_9ARCH/89-190   AC A0A1D2R468.1
#=GS K0IEG8_NITGG/105-205      AC K0IEG8.1
#=GS A0A8J7XAI9_9EURY/86-182   AC A0A8J7XAI9.1
#=GS G4RKP6_THETK/86-181       AC G4RKP6.1
#=GS B1L5G1_KORCO/106-198      AC B1L5G1.1
#=GS A0A650CRL9_9CREN/101-205  AC A0A650CRL9.1
#=GS A0A0X8V083_THEX5/97-195   AC A0A0X8V083.1
#=GS M9SBP0_METAX/96-194       AC M9SBP0.2
#=GS W7KUV6_9CREN/100-199      AC W7KUV6.1
#=GS M4YK62_THEXX/96-194       AC M4YK62.1
#=GS A0A2H1EGK6_9ARCH/107-206  AC A0A2H1EGK6.1
#=GS A0A0A7LB33_9ARCH/96-194   AC A0A0A7LB33.1
#=GS R9T642_METII/98-196       AC R9T642.1
#=GS A0A0F7FGK5_9CREN/89-189   AC A0A0F7FGK5.1
#=GS A0A0X8V2G2_THEX5/134-231  AC A0A0X8V2G2.1
#=GS A0A0Q4B655_9ARCH/96-194   AC A0A0Q4B655.1
#=GS A0A110A3A4_THEX5/7-82     AC A0A110A3A4.1
#=GS R9T598_METII/96-194       AC R9T598.1
#=GS A0A484IEJ6_9ARCH/152-252  AC A0A484IEJ6.1
#=GS A4YHF7_METS5/100-199      AC A4YHF7.1
#=GS A1RW52_THEPD/89-186       AC A1RW52.1
#=GS A0A510DUD4_9CREN/100-202  AC A0A510DUD4.1
#=GS A0A2H5V6N7_9ARCH/105-202  AC A0A2H5V6N7.1
#=GS A0A348B3C6_9CREN/150-236  AC A0A348B3C6.1
#=GS A0A4P2VAM2_9ARCH/96-185   AC A0A4P2VAM2.1
#=GS A0A133VAU4_9EURY/89-134   AC A0A133VAU4.1
#=GS A0A060HQB6_9ARCH/130-229  AC A0A060HQB6.1
#=GS A0A5B9D5S2_9ARCH/113-206  AC A0A5B9D5S2.1
#=GS S5Z5Q3_9CREN/89-188       AC S5Z5Q3.1
#=GS A0A133UGY3_9EURY/77-173   AC A0A133UGY3.1
#=GS A0A2U9IG17_9CREN/100-199  AC A0A2U9IG17.1
#=GS M9SBM1_METAX/72-170       AC M9SBM1.1
#=GS A0A133V3A7_9EURY/93-189   AC A0A133V3A7.1
#=GS A0A2U0RYS7_9ARCH/119-218  AC A0A2U0RYS7.1
#=GS Q97ZM2_SACS2/101-199      AC Q97ZM2.1
#=GS A0A0W7THG6_9ARCH/71-169   AC A0A0W7THG6.1
#=GS I0A1G9_FERFK/106-212      AC I0A1G9.1
#=GS M9SBH2_METAX/98-194       AC M9SBH2.1
#=GS Q971Y2_SULTO/101-206      AC Q971Y2.1
#=GS A0A110A3I9_THEX5/96-193   AC A0A110A3I9.1
#=GS E6N5L5_CALS0/105-202      AC E6N5L5.1
#=GS A0A557STP4_9ARCH/113-213  AC A0A557STP4.1
#=GS A0A0X8V0F3_THEX5/99-197   AC A0A0X8V0F3.1
#=GS A0A133UJS1_9EURY/93-189   AC A0A133UJS1.1
#=GS Q4J8Z3_SULAC/101-204      AC Q4J8Z3.1
#=GS A0RX25_CENSY/101-198      AC A0RX25.1
#=GS A0A2K5ATD4_9ARCH/110-208  AC A0A2K5ATD4.1
#=GS A0A133V153_9EURY/70-142   AC A0A133V153.1
#=GS A0A133UFV4_9EURY/93-189   AC A0A133UFV4.1
#=GS F0LHD9_THEBM/106-204      AC F0LHD9.1
#=GS V6AT36_9ARCH/83-182       AC V6AT36.1
#=GS H2C8E3_9CREN/100-199      AC H2C8E3.1
#=GS A0A031LPA6_9CREN/100-199  AC A0A031LPA6.1
#=GS A0A133VNZ5_9EURY/91-187   AC A0A133VNZ5.1
#=GS A0A832V0E0_9ARCH/90-188   AC A0A832V0E0.1
#=GS E0SR06_IGNAA/112-212      AC E0SR06.1
#=GS A0A0W7TIU4_9ARCH/98-194   AC A0A0W7TIU4.1
#=GS M4YK26_THEXX/98-194       AC M4YK26.1
#=GS A0A2H5V1J8_9ARCH/107-204  AC A0A2H5V1J8.1
#=GS K0I8K1_NITGG/105-207      AC K0I8K1.1
#=GS S2E8G6_9ARCH/106-205      AC S2E8G6.1
#=GS Q8U1U2_PYRFU/111-203      AC Q8U1U2.1
#=GS A0A8K1DCW1_9ARCH/111-210  AC A0A8K1DCW1.1
#=GS A0A832XIE5_9ARCH/90-188   AC A0A832XIE5.1
#=GS A0A133U5S7_9EURY/93-189   AC A0A133U5S7.1
#=GS A0A133V8Q9_9EURY/91-187   AC A0A133V8Q9.1
#=GS A0A6B9TBB6_9ARCH/85-183   AC A0A6B9TBB6.1
#=GS A9A1E1_NITMS/107-206      AC A9A1E1.1
#=GS M9SHL5_METAX/97-195       AC M9SHL5.1
#=GS A0A6B9TBH3_9ARCH/96-192   AC A0A6B9TBH3.1
#=GS R9T5Y7_METII/98-194       AC R9T5Y7.1
#=GS C6A441_THESM/86-186       AC C6A441.1
#=GS A0A8J7NCI2_9ARCH/93-194   AC A0A8J7NCI2.1
#=GS F4B4M1_ACIHW/100-199      AC F4B4M1.1
#=GS A0A133V5U7_9EURY/93-189   AC A0A133V5U7.1
#=GS A0A0X8V2H2_THEX5/95-193   AC A0A0X8V2H2.1
#=GS A0A5B2YZ35_9ARCH/105-205  AC A0A5B2YZ35.1
#=GS A0A133UEN7_9EURY/93-189   AC A0A133UEN7.1
A0A0X8UZR3_THEX5/93-189              ..............IGDCNC...AVLVPN.AADRVK.YGCEE....RDNAILSGATGATTLIFTK..GSLIFP....GNEYPVDT---KADKAIRT.TF.NLREGDVIIIGTA..PTM.AAAEEGAVSAGLKLL...............................
A0A0X8V292_THEX5/105-202             .............r-GEYQQ...GIIIKG.RSEDIQ.NGMKQ....RDIGIKYGSDGASVFIMRN..GSIIFP....-KDVNVDESDPEFAKEIRS.-T.GMSEGDVLIIVGS..DSL.PTSRIAAAGIGLETI...............................
Q5JDB2_THEKO/86-187                  ......vgkvdgmp----AY...AIVVKN.--PPQF.KSIEL....RDEAIRFFAKGAMILIVKN..GEPVFP....EDERPLRDTMEELAMNIEE.VL.NFSDGDLIVVTWA..ENP.SDAMKSAYHVALTL-k..............................
A0A6A7LE78_9ARCH/105-205             ..............LGKYNY...AVLLKQ.ISFAVK.SGIEQ....RDAAIKMGAIGATTLFYTN..EKFIIP....GTKYDTLKREPHIGQLLVH.KL.KPEYMDVVIIGSD..DTDkRVAELAAKNAALLT-v..............................
M9SHY7_METAX/72-170                  ..............IGTYQV...SLLLKG.KAKMIE.KGVEQ....RDAALKSGGDGCTTIILRD..GELILP....-PDWSIDEHSPELAAQIRA.-H.GMEEGDVVLIGGS..NTGrREAAVAANSAALELI...............................
A0A7L9FFM4_9CREN/86-186              ............at--ELNA...AVVVVG.IARSVQaSKINVl.glRDDAVRGGALGAIISVYRG..GSLKLP....PADVDLCEYASNLCREITR.RK.SLEENALIIATFG..DKL.VDALSGFI-------slle...........................
A0A0A7LDW2_9ARCH/117-213             ..............IGKCDC...AVRVPG.MAGNIK.FGCEE....RDVAIKNGAMGATTLICSN..NMLIFP....GSYYPVDQ---KIENRLRD.HL.DIMDGDAVIIGTA..SDD.DRAELGAVTAALETM...............................
A0A087S7U8_9ARCH/67-166              .............q-NKNNH...AIILKK.FSSAIK.TGLEQ....RDYAIMYGSSGCTTLVFKN..NKFVFP....GEDKDCLSKDKKTKQTLMK.EL.DPSEGDIVIISSS..DDS.FVAEISAKNSALWTI...............................
A0A2H5UWV9_9ARCH/108-206             ............rs--EQNI...AVVVSG.VKGLKG.TGVEQ....RDVAIRYGASEAMVLTYER..DGLHMP....-KVANLSVERPEFSSKIIN.RL.RPKPGDIIIITGS..PDL.ATSKYSALGAALSLI...............................
A0A133VD29_9EURY/91-136              ..............VGEVDV...ATIVRH.AYENVK.LGIRQ....RDEAIKAGADGATVLVFSD..ERF---....-------------------.--.-------------..---.---------------k..............................
A0A1D2R468_9ARCH/89-190              .............v-GGRKT...GIVVHA.ASGKIT.TGLLE....RDMAVRTGASGAIVLKYDNkaKKLTFP....-DEVRQVEDFPGFKNEIESlNI.YFNSGDVLVVAFS..DDY.IVSENAALEIALRL-v..............................
K0IEG8_NITGG/105-205                 ..............LGRFNY...AVLVRE.FGFAVR.SGIEQ....RDAAIKMGATGATTLIFKE..GKFVMP....ASTHDSLKKEPQVRRMLVE.KL.RPKEGDVVIIGSA..DSSeKTAELAAKNAALLTI...............................
A0A8J7XAI9_9EURY/86-182              .............l-SNYSV...ASLISD.FSYHIK.NGIKI....RDAALISGASGATTLLYKN..GGFAFP....HGTTPLP---PSIEEYLIH.EF.SPSEHDVLIISTA..DTE.SQAIRGISGCL----slli...........................
G4RKP6_THETK/86-181                  ..eklcgrvcvafs------...------.LGIKID.NIVKF....RDSVVRRGSCGIIIAQLRD..NNIYIP....LAEMRLEDLDPEMAGSIKG.--.LLSREDFLIISCG..DNF.GQA------------laplevvcem.....................
B1L5G1_KORCO/106-198                 vyltlvrcvnyldi------...------.------.--LDL....RDEAVRFGGKGALIFAVRG..KRVIFP....ETGEDLSIYAPNDSKLLES.-L.GASDGDLIIIGLS..EDP.QISKLSSLGASLL--ai.............................
A0A650CRL9_9CREN/101-205             ..........lrti----NWnagCVIMRNlSHLVDK.IGILQ...lRDLIIKSGASKTLIGTITE.eCNIELPpktfEESDEVKKLKEEIKEKLKG.--.SIQPHDLVIFFEP..SSN.----YLAYKIIL---tlyy...........................
A0A0X8V083_THEX5/97-195              ..............VGEFSQ...GVIVYG.VGNKIV.NGMEQ....RDAGIKAGAFGCTTVVLRE..GKLLIP....-PDWNLDEQSPELALKIRK.ES.GITSDDAIIVGSG..ATK.VVAIEAALNAAFELL...............................
M9SBP0_METAX/96-194                  ..............VGDFTQ...GVIVYG.ASSKIV.NGMQQ....RDAGIKAGAEGCTTIVIRD..GKLMIP....-PDWNMDEQTPELAYKIRK.DT.GITADDVIIVGGG..SSK.IAAVEAVLNAAFELV...............................
W7KUV6_9CREN/100-199                 .............l-NSINWdtmEIVIRRgVKILER.MGIIN...lRDTVIKNGAESTLIAVVTD..KGIELPp..kTDELSMGNLLQEIRESCPT.--.-CAPGDLIVFVTP..QNK.----YIAYKVAVNL-v..............................
M4YK62_THEXX/96-194                  ..............VGSHQQ...GVVVFG.VSSKIV.NGMQQ....RDAGIKAGASGCTTIVIRN..GALMIP....-PDWNMDEQTPELAAKIRK.ET.GIGPEDVIIVGSA..DSQ.ISAVEASLNAAFDLI...............................
A0A2H1EGK6_9ARCH/107-206             ..............LGKFNH...AVLVKN.MAYNIR.SGIEQ....RDAAIKAGAVGATTLVCKN..DRLVLP....GTDEDLIKNNKDIHHIIME.KL.SPEQDDVIIIGSS..QSK.KIAERAAKSAALYTI...............................
A0A0A7LB33_9ARCH/96-194              ..............VGSFSQ...SVLVMG.VADRVY.NGMQQ....RDAGIKVGATGCTTVVIRD..GALMIP....-PDWNVDERNPELAYKIRK.ET.GITQNDAIIVGSA..DTK.MLAVEAAINAAFELI...............................
R9T642_METII/98-196                  ...........pnq---CCC...GIIVFK.QSSKIQ.DGIRQ....RDICIKSGANGCITFILKD..GKLTIP....-PGRNLDEEYSDSLKKIER.SL.CLAEGDVLILSYS..VDE.CAAANAAVMASLDLI...............................
A0A0F7FGK5_9CREN/89-189              ...........lgs----KV...AVIAETiLPYTGK.VKILE...lRDEAVRGGAKGALILTYHE..GKLRVP....PIEEDLCFYAVKLCREVLG.NT.HPREGSMVFIVFA..ESL.GEALSGFVNILE---skh............................
A0A0X8V2G2_THEX5/134-231             .......dckaefv------...-LLAHG.KGHLMD.SDIKY....RDGAIMMGASVCMPFRMDG..GKVTVP....-YYDAVQLEYPDLSELA-E.RI.GMKDGDAGMLCGA..ASI.QVASSAAFGGMLKL-l..............................
A0A0Q4B655_9ARCH/96-194              ..............LGEYSV...AVQVKG.VASKVK.SGMEQ....RDQAIKAGADGATTVVVNG..DRLTVP....-VDFDLDKGRPETAWALRR.LF.DLSDGDVIIIGTS..VSL.QRAEEGAMAAAFELL...............................
A0A110A3A4_THEX5/7-82                ...........dnn------...------.------.-----....---ALEVCGDGCPTIILRD..GELILS....-PDWSIDEHSPELAAQIRS.-H.GMKEGDVVLIEGS..NTGmREAAAAANSAALELV...............................
R9T598_METII/96-194                  ............hg--RKGV...AVQVKG.VEDKIG.SGMEQ....RDRAMIAGADGATTVLVKN..GKLQIP....-GGIDLEGIYPDTASTLSK.LF.DLENGDIIIIGTA..SEY.ELAEEGAVTAALDLI...............................
A0A484IEJ6_9ARCH/152-252             ..............ISKFNY...AILLIY.MSNAIR.QGIEQ....RDAAIKMGAKGATTLIFEN..GKFSIP....GSKYNVLRNEKSLELLLKD.GL.RPINNDVIIIGSD..DSSlILAELAAKAAALYT-l..............................
A4YHF7_METS5/100-199                 ....inslnwkaiq------...LVILGG.KNLVER.EGVIQ...lRDLIIRTGAEATLITIKEN..QGIEIPp..kTEDFSMKSLLQEVALLSS-.--.SLPVGSLIIYLIP..QDI.----HLAYKVGI---sll............................
A1RW52_THEPD/89-186                  lnareavyvllhgy------...------.--PPAE.NVVKL....RDEAVREGADGAVIAVFDG..GKFRLP....PGGEDLCSYAPRLCGEVLG.--.EAEEEDCLLVVFG..ERL.GAAVKGLVGILLS--ek.............................
A0A510DUD4_9CREN/100-202             .......lksigwd----SY...GILLRGgESLLRQ.HGVLE...lRDEVIKQGAERVLIAVFEN..GKIEIPp..kTDDMAMGNLLQEISEAFKE.--.-AKEGDMAIFITP..QDL.RLALKVSVKIL----env............................
A0A2H5V6N7_9ARCH/105-202             ............ap---ANY...GLVVKG.LAERIS.TGLEE....RDEAVRHGASAAMVLTFLS..DGVHMP....-RVSNLSVERPEFAEQVKS.FF.KPEVGDVIIITGA..EDE.PRAMYSALAAALKI-l..............................
A0A348B3C6_9CREN/150-236             ....lrvvggtell------...------.----SK.TSVVE...lRDLGVKSGATAVLVAVFRD..GKVELP...pMTVEEVEPLLREVRDSCPR.--.-CSDGDVAFITTP..RTP.Q--------------vpynlsiw.......................
A0A4P2VAM2_9ARCH/96-185              .........ggeva------...CVIVKN.GCGVLG.TGVMH....RDEAVKGGADGALIMIRQG..DKYVFP....--DWSYEY-----PVKV--.SP.EPPDGACVVIAWA..GSR.SLAINGVMRAASSI-l..............................
A0A133VAU4_9EURY/89-134              ..............VGEVDV...ATIVRK.ASEKVK.LGIRQ....RDEAIKAGADGATVLVFSD..ERF---....-------------------.--.-------------..---.---------------k..............................
A0A060HQB6_9ARCH/130-229             ..............LGRHNY...AVLLRE.FGFAVR.SGIEQ....RDAAIKMGAAGATTLLYRD..GRFAMP....DSGQDPLKKEQTLKKELAD.TL.KPQEGDVVIIGSA..EKG.KVAELAAKSAALATI...............................
A0A5B9D5S2_9ARCH/113-206             .............v-GKIAY..ySIVDQEnIKNNLG.SSINQ....RDEAIKIGGTGASCLTFNE.sNKFEFS....---DGVSINLPIEQKKLKN.--.----GDILIIGGG..NSK.GDAILATYASAISV-l..............................
S5Z5Q3_9CREN/89-188                  ........lgsqtv------...-VYVLL.RKESVP.SNVLK...iRDQAVKEGADGAIIGIFSG..DTFKLP....PGNEDLCMYAPLFCTEIKP.KI.-------------..---.---------------igepprltllavfgdkkgktieglvaillse
A0A133UGY3_9EURY/77-173              ..............VGEKDV...MTLVQQ.AGSKVH.LGVRQ....RDEAIKAGAQGATVLIFRD..GELQLP....GVAREIDE---KVASIIES.EM.EPFDEDVIIIGSG..ETE.KEAERAALAAAKSL-e..............................
A0A2U9IG17_9CREN/100-199             ..........lnsi----KWksiEIILKNgRNILDK.IGVIP...lRDSIIKTGADSVLIAILTD..KGIELPp..kTDELSIGDLLNEIKNNCTF.--.-CNKNDLIVFIIP..EDN.----YIAYKVALLLI...............................
M9SBM1_METAX/72-170                  ..............IGTYQV...ALLLKG.KAKMIG.KGVEQ....RNAALKSGGDGCTTIILRD..GELVLP....-PDWSIDEHSPELAAQIRS.-H.GMEEGDVVLIGGS..NTGrREAAVAANSAALELV...............................
A0A133V3A7_9EURY/93-189              ..............VGKVSV...ATMVKD.AIEKVR.RGIEQ....RDEAIKVGAQGATTLVYRD..EDLELL....CSETQLDK---EIKSELLE.FF.QPSENDIIVIGTA..DSK.KYAERGALAAAESL-s..............................
A0A2U0RYS7_9ARCH/119-218             .............f-GSCNV...AVLVRN.SAKAVG.SGMEQ....RDSAIKIGASGATTLIFSN..NKLSLP....TGEENLSESMPELHAKLVT.QF.NPKENDVIIIGSG..KNR.ALAEIGATMAAIKLL...............................
Q97ZM2_SACS2/101-199                 ......kslgwnss------...MLIVRGgAELLKE.ISVLH...lRDEIIRLGAEKILVCVYTE.eGKIEIPp..kTEEMSLRGLLDEIKENCNN.--.-CGPNDLIIFLVP..NEE.---------------hlgyltltfi.....................
A0A0W7THG6_9ARCH/71-169              ..............IGEFSF...SLVVAG.AAGRVG.SGTAQ....RDAGIRSGGSGCTTWVIRG..GKLLMA....-PEWDVDANDPRSAAAIRG.SV.SLAEGDALVIGGG..PTL.RDARAAAVGAALSLV...............................
I0A1G9_FERFK/106-212                 ......gmnaweri------...-IIIFIaQSCKRR.ISLKEtvmlRDSAIRWGAEGSIILQYCN..METNIPg..iEDLSIRNEIEKEIKKELQK.--.-LENGLYIIIGMNykERE.MSVVYGILKTACEL-s..............................
M9SBH2_METAX/98-194                  ..............IGAINC...AVQVPR.AANKVK.FGCEE....RDNAIKSGAAGATTLIYSN..GILMFP....GNEYPLDI---KSDKAVRA.AF.NLSNDDAIIIGTA..DTP.EAAEEGAVSAGLELL...............................
Q971Y2_SULTO/101-206                 .....ltsinwkse------...LIKIKNgRIILEK.MGLLN...lRDLIIKQGATRTLIAVINE.eGRIELP....PKTFDESEEIKKLKEELQS.KVnKLEINDLIIVFEP..VNQ.HLAYKIALAIL----tsa............................
A0A110A3I9_THEX5/96-193              .............k-GEYQQ...GILIKD.KADAIT.NGMKQ....RDIGIKYGSEGASVFVMRN..DRIIFP....-PDVKVDERDPEFAKKIRA.-V.GMSEGDVLVIVGS..EDL.PKSRIAAAGIGLETI...............................
E6N5L5_CALS0/105-202                 ............ap---ANY...GLVVKG.LAERIS.TGLEE....RDEAVRHGASAAMVLTFLS..DGVHMP....-RVSNLSVERPEFAEQVKS.FF.KPEVGDVIIITGA..EDE.PRAMYSALAAALKI-l..............................
A0A557STP4_9ARCH/113-213             .............i-AEYNH...AILLRN.LKFAIK.QGVEQ....RDAAIKMGAKGATTLMYND..GKFLIP....GSKFNALKEEKAIEKLLKE.NL.KPIENDIIVIGSD..DNNyITAEFASKSAALQTL...............................
A0A0X8V0F3_THEX5/99-197              ..............IGEYQV...ALLVRG.MAGMID.KGVEQ....RDSGLKSGGDGCTTVVCKK..GKLILP....-PDWDVESNTPELASQIRR.-Y.SITEGDIVLIGGS..NTNrTMAAAAANSAALELL...............................
A0A133UJS1_9EURY/93-189              ..............VGKVSV...ATMVKD.AIEKVR.RGIEQ....RDEAIKVGAQGATTLVYRD..EDLELL....CSETQLDK---EIKSELLE.FF.QPSENDIIVIGTA..DSK.KYAERGALAAAESL-s..............................
Q4J8Z3_SULAC/101-204                 .......iysiqwk---VNG...VVILNG.INILNK.IGILD...lRDNLVKLGASKILIAVKND..NQIELP....PKTFDESEEIKRLKTELIE.KF.SNIPSDSLIILFE..PQD.I---HLA--------ykiifallni.....................
A0RX25_CENSY/101-198                 .............g-GESSH...AVMLRG.CAGSVR.SGVEQ....RDYAVMYGAGGAMTLVYKG..GRYTFP....-DGRDAAFPGGAIQGALSG.-L.GPIDGDVLIIAAA..GDS.FTSEMAAKNSGLLT-v..............................
A0A2K5ATD4_9ARCH/110-208             ..............VGEFNY...AVKVRG.IANAIR.SGVEQ....RDAAIKVGALGATTLVYRG..SRFIMP....GSGNSVYIKEQDVMDRLKD.-L.MPEEDDVIIIGSA..SNV.KVAELAAKYAVLTT-l..............................
A0A133V153_9EURY/70-142              ..............VGEVDV...ATIVRK.ASEKVE.LGIRQ....RDEAIKAGADGATVLVFSD..GRFKIP....GTQIDLEP---KIENRLSK.AF.QPTDSDV------..---.---------------...............................
A0A133UFV4_9EURY/93-189              ..............VGEKDV...MTLVQQ.AGSKVH.LGVRQ....RDEAIKAGAQGATVLIFRD..GELQLP....GVAREIDE---KVASIIES.EM.EPFDEDVIIIGSG..ETE.KEAERAALAAAKSL-e..............................
F0LHD9_THEBM/106-204                 .......kvenmpt-----Y...ALIVKN.--PPQF.KSIDL....RDEAIRYFAKGAMILVYKA..GEIVFP....EDERPLKETLPRLAEDLKK.-L.SPKEGDLIVVTWA..ENR.ADAIKSAIHVALTL-k..............................
V6AT36_9ARCH/83-182                  ..............IGKFNH...AILLKK.YAFATK.SGTEQ....RDFAIMYGATGATTIIFRD..GRFTFP....NDTADCLLNDKNTKKTLCN.FL.KPENEDMIIITSA..NEP.FVAEISAKNSALWTM...............................
H2C8E3_9CREN/100-199                 .....inslgwdgv------...KVVIRKgERLVTR.LGVIN...lRDSIIRLGAEAVLIVVKTQ..TGVEIPp..kTEEFTIRSLLDEVKRDTEY.--.-VSPGDLIVYLIP..KDL.----HLAYKVGLY--ll.............................
A0A031LPA6_9CREN/100-199             ............ie--SINWdsvRIVLKNkANLLDK.YKITE...lRDIIIREGAKATLIVVKGK..KGVEIPp..rTDEFALPGLLEEIKEKLLD.--.-CSSGDLILYIMP..DNI.----YLAYRI-----gifll..........................
A0A133VNZ5_9EURY/91-187              ..............VGNVDI...ATIVRG.GAKKVR.DGIKQ....RDEAIKAGAEGATILVMKE..SELQLA....DRSAEVNK---KVAAKIKN.SF.HPQEGDAIVIGTG..KNR.EEAERGTLVATKSL-s..............................
A0A832V0E0_9ARCH/90-188              ............fg--DFSA...AFKISN.SSSMIN.LGLEQ....RDAAVRSGAEGCLVLIFKN..NKLILP....-GVDSIETVYHDIFSGIKE.NF.KLSEGDVIIVAFA..NTK.RQAELGAFAAAKTL-l..............................
E0SR06_IGNAA/112-212                 .............i-CNYAF...AALLTKfRLRAES.IGIAN...iRDMAIRNGAKAALVIFIKN..SKAYLP....-PDESINEERYKSLYRIKN.FL.DASEDDVIIVTFS..DDR.ITAEKALYNTIVELI...............................
A0A0W7TIU4_9ARCH/98-194              ..............IGEHDC...AVRVPH.AAGKIT.YGCEE....RDNAIKNGALGATTLVFSN..GQLTFP....GDSYPLDE---KYDRILKK.TF.SLSDSDAVIIGTA..DSY.AAAEEGAVSAGLELL...............................
M4YK26_THEXX/98-194                  ..............IGHYNC...AVQVPR.AAFRVK.YGCEE....RDSAIKSGATGATTLICSN..GMLMFP....GNEYPVSA---KAEKAIRN.AF.SLNNEDVIIIGTA..DTP.EQAEEGAVTAGLELI...............................
A0A2H5V1J8_9ARCH/107-204             ............yp---FSV...GIVVRG.GASLVR.RGLEQ....RDAAIRAGAKGAMTLVYHS..DRLLMP....-GISDVTAEHPEFANKILE.EM.RPEEGDAIIVAGA..ESL.HDAENGAVAAALVT-l..............................
K0I8K1_NITGG/105-207                 ..............LGKYNH...AVLLKN.LSFAVK.SGIEQ....RDAAVKMGAIGATTLSFKD..SKFVMPm..dSSGYDSLEKEPNIRKLLVE.KL.KPEEEDIVIIGSA..NDSsRTAELAAKNAALVT-l..............................
S2E8G6_9ARCH/106-205                 .............q-CKFNH...AILIKN.YSKMIK.TGLEQ....RDYAILYGSEGCITVVCKN..KKLIFP....GEDKECFIGDSKTRDYILE.KL.SPDEGDVIIISSS..DDP.FVAEISAKNSALWTL...............................
Q8U1U2_PYRFU/111-203                 ........vdgfpg-----V...AIIVKN.--PGGF.KSLEL....RDEAIKFDAKGAMILTVKN..GEIVFP....EDSRPLKEMYPEIVKRLYD.--.-YEEGDLIVITWA..DKI.GRR------------lkqpsrcsr......................
A0A8K1DCW1_9ARCH/111-210             ..............IGKFNH...AILVKG.LAKDVG.SGIEQ....RDAAIKIGALGATTLVFRN..DKLFTS....DKSYDIPIKDQKLTVVLVE.KL.QPENGDVVIIASA..ENK.KIADLAAKRAALETI...............................
A0A832XIE5_9ARCH/90-188              .............y-GNFSI...AFRIVN.AASMVS.VGLEQ....RDSAIRAGAAGCLVLVYRG..NRLILP....-GGEGMENVYIDIFNGVSQ.NF.KLAEGDAVIVAFA..NAK.RHAEIGAWAAAKTL-l..............................
A0A133U5S7_9EURY/93-189              ..............VGKVSV...ATMVKD.AIEKVR.RGIEQ....RDEAIKVGAQGATTLVYRD..EDLELL....CSETQLDK---EIKSELLE.FF.QPSENDIIVIGTA..DSK.KYAERGALAAAESL-s..............................
A0A133V8Q9_9EURY/91-187              ..............VGNVDI...ATIVEG.GAKKVR.DGIKQ....RDEAIKAGAEGATILVIKG..SELQLA....DQSAEVSK---KVAAKIKD.YF.HPQEGDAIVIGTG..KNR.EEAERGALVAAKSL-s..............................
A0A6B9TBB6_9ARCH/85-183              ..............VGKYQQ...AVLVLG.CADKVV.NGMEQ....RDIGIKVGGEGCTTIVIRD..GNLLIP....-PDWNLDEKDPELAYNIRK.ET.GITKSDALIIGGG..DTK.TSAVDAAVSAALNM-f..............................
A9A1E1_NITMS/107-206                 ............ps--KNNH...AIILKK.YSSAIK.TGVEQ....RDYAIMYGSSGCTTLTFKN..NKFVFP....GEDKDCLNKDKKTRQILLE.KL.EPSDEDIIIISSS..NDS.FVAEISAKNSALWTI...............................
M9SHL5_METAX/97-195                  ..............IGEHSQ...GILVSG.ASEKVF.NGIDQ....RDAGIRAGGDGCTTWVVTS..GGIIML....-PDWNVDDKDPGFAAALRI.SA.CPIDGDVLIIGGG..NSR.RLAMMASATAALELL...............................
A0A6B9TBH3_9ARCH/96-192              ..............IGDRDC...AVRVPK.MARNVK.YGCEE....RDAAIKSGATGATTLIYSN..GKLIFP....GSDYPVDP---DVESKIRS.VF.SLKNDDVVIIGTG..PTE.ESAEVGAVIAGLTI-m..............................
R9T5Y7_METII/98-194                  .............i-SSQDC...AVLVKG.MAAHMS.NGNEQ....RDEAVYSGAEGATSFVAKN..GKLYYP....CSNMSPDE---ETTACLKT.AF.NIRDGDVIIIGTA..KKY.RLAEQGAVTAALAL-e..............................
C6A441_THESM/86-186                  ......vcsiedfl----AY...AIVVKD.--PPQF.KSIEL....RDEAIRFFARGAMILRYLN..GEVIFP....EDNRPLKETLPEIAEDLEK.-L.PLEDGDLIVITWA..ENR.IDAVKSAIHVALVL-k..............................
A0A8J7NCI2_9ARCH/93-194              .............k-GSKNV...AVLVKG.SSNKIK.TGMEQ....RDAAIRIGRGGVTTLLYKK..GKLIMPg..fGDDMVLDKKYPEDSKAILD.AI.EPQDGDVIVIGSE..DSN.QKAEEAAW-------igastil........................
F4B4M1_ACIHW/100-199                 .............l-KSINWdcsMIIVKGgSKILEK.QKVIE...lRDKIIKLGADSVLISVILN..NKVELPp..kTEEFGMKELLEDIKNSCRL.--.-CENNDLITYILP..KDL.----HLAYKVGL---llf............................
A0A133V5U7_9EURY/93-189              .............v-AEEDV...ATIARN.AESGIR.RGVEE....RDEAMKAGAEGATILVSKD..QGLRMP....GVGDEVEE---DIASELVE.GL.NPSEGDVIIISSG..ENR.RDAERGALAAAESL-q..............................
A0A0X8V2H2_THEX5/95-193              ..............LGTYNQ...GIKVFA.AAGKIG.DGMEQ....VKVSTAYGGVGCTTWVMKN..DQIHMP....-PHWEFSRSNVDASEKIMD.EA.DMHNGDVFLMCGA..ESP.RAARVAAMMVALDL-v..............................
A0A5B2YZ35_9ARCH/105-205             ..............VSEFNY...AILLRH.LKFAIK.QGVEQ....RDAAIKMGAQGATTLIFKD..GKFLIP....GSSYNALKYEKNVERILKD.KL.NPINDDVIIIASD..NSSyIIAELASKAAALYT-l..............................
A0A133UEN7_9EURY/93-189              .............v-AEEDV...ATIARN.AESGIR.RGVEE....RDEAMKAGAEGATILVSKD..QGLRMP....GVGDEVEE---DIASELVE.GL.NPSEGDVIIISSG..ENR.RDAERGALAAAESL-q..............................
#=GC seq_cons                        ...............sphsh...ulllcs.huttlc.pGlcp....RDtAI+hGApGAssllhcs..sclhhP.....sshslsp...cltpplpp..h.p.pcuDllIIusu..sst.t.A.huAhsuAlth................................
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