#=GF ID   DUF4627
#=GF AC   PF15425.10
#=GF DE   Domain of unknown function (DUF4627)
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Jackhmmer:217257
#=GF GA   24.90 24.90;
#=GF TC   25.10 25.40;
#=GF NC   24.70 22.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF CL   CL0202
#=GF DR   INTERPRO; IPR027959;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family of proteins is found in bacteria. Proteins in this
#=GF CC   family are approximately 230 amino acids in length. There is a
#=GF CC   conserved WYK sequence motif.
#=GF SQ   25
#=GS R5JIK5_9BACE/465-660      AC R5JIK5.1
#=GS R6D8R9_9BACE/308-493      AC R6D8R9.1
#=GS R5JIK5_9BACE/253-447      AC R5JIK5.1
#=GS A0A6M1E6N4_9SPHI/22-218   AC A0A6M1E6N4.1
#=GS E5C4Y1_9BACE/21-230       AC E5C4Y1.1
#=GS R5IQY0_9BACT/251-469      AC R5IQY0.1
#=GS A0A3P2ACM9_9BACE/364-547  AC A0A3P2ACM9.1
#=GS Q89ZG6_BACTN/21-230       AC Q89ZG6.1
#=GS R5VDU0_9BACE/21-220       AC R5VDU0.1
#=GS R6FEB6_9BACE/317-488      AC R6FEB6.1
#=GS A0A174FYL3_9BACE/21-230   AC A0A174FYL3.1
#=GS W4P8U4_9BACE/1-139        AC W4P8U4.1
#=GS W4P8Y5_9BACE/21-92        AC W4P8Y5.1
#=GS I8XTY0_9BACE/325-519      AC I8XTY0.1
#=GS R6D7Y9_9BACE/21-230       AC R6D7Y9.1
#=GS I8XTY0_9BACE/1-97         AC I8XTY0.1
#=GS A0A174WVU6_9BACE/21-230   AC A0A174WVU6.1
#=GS R6DIY2_9BACE/67-229       AC R6DIY2.1
#=GS R5IQY0_9BACT/15-210       AC R5IQY0.1
#=GS U2HVY7_9SPHI/22-218       AC U2HVY7.1
#=GS A0A6M1N2T8_9SPHI/22-218   AC A0A6M1N2T8.1
#=GS R5JIK5_9BACE/44-237       AC R5JIK5.1
#=GS R6DAM7_9BACE/321-500      AC R6DAM7.1
#=GS A0A3L7Z3P1_9BACE/21-230   AC A0A3L7Z3P1.1
#=GS I8XTY0_9BACE/113-307      AC I8XTY0.1
R5JIK5_9BACE/465-660                 ............................NLVKDADFE.S.NPDL.TLQLEEPTVC--.........GQWVAYKDQYE-TNV-VTIGVSDD..TT.QGKVAAITGKT..--SSWYTTVLSQRID.GTVPLGIYRFSFLGRS-DDGGQLRVYTRATDE....NNSNVNKFFIKETGKPSD.P.....TQSWYGCWQSFTL...TDTWKEYYVDFNLSKTANSMYQWT-....--FDQGIVKNA-----TDIDLTNLNICFLGNKENATVYIDNVS-f.............................
R6D8R9_9BACE/308-493                 nwiqrtiddlptgaikvetvndkpwqye---------.-.----.-----------I.........GNWIFVAKSVNQIGE---AAVIND..SSlEHNVIHCKIND..-NNTWYKTYIAHRMP.-TPKREVYTLKFKMKG-TANKSVRCIILREDK....-----KIIAI-------N.A.....PDNKYQGAYMLNL...TEEYKEYQIDFDFSKQVLSIY----....-----NTVTDY--TETTDEVLENLFLQFSPANNDTEFYLYDVV-l.............................
R5JIK5_9BACE/253-447                 ...........................e-LIKDSDFE.N.AD-F.TKTFDATPVV-F.........GEWVTYTDAKNEKNN-ISYIVADD..AV.RGKVGSYTGKP..--YSWYTSFFAQRIE.TTAKKGIYKLSFWGKS-TDGGKAKVYIRTTDA....GGKDVQKFFIKETGKPSD.P.....SSKWYGSFYSTAL...TAEWVEYSVEFDFTKTINSMYSAP-....-------LSDA--IDADDIDLTDFSICFQGDIADKTILIDGVSL..............................
A0A6M1E6N4_9SPHI/22-218              ............................NLIEDGKFEdT.SFTV.YDIYRKFPGP--.........GKWYPYLTS----DKQAVMSVIQD..ND.KGKAVSIQTLT..-GTSYAYSFIGQRVE.KNVSEGIYTLKFWAKA-TKDIRTSVGVYLKVK....TPKSQTLYFPISGFDP-Q.T.....TPSRSGALKTLIL...SNEWKEYTVEFDLSQVVNSVPSPK-....V-----SKTEVIVKKSEVDHRKSFDVAIACMTKNSGMLFTDVSL..............................
E5C4Y1_9BACE/21-230                  ............................NLIKNEKFA.T.EVKT.KVTNANKATA--.........GEWFIMNNEADGATT-IAWEQTGD..AK.YPNAMKLDNSGadKNISWYKAFLGQRIT.DGLEKGVYVLTFYAKAKEAGTPVGVYIKQTNEekndNGKYNTTFFMRRDYDA-D.A.....QPNASGAQYNFKIk.dADKWTKVVVYYDMGQVVNAISSKK-....-ANADLEVSDT---DDDAAILKDCYLAILSQNKGGVVEISDVTL..............................
R5IQY0_9BACT/251-469                 ...........................d-FLKDGDFE.L.DVDE.IQNWRTLDKGKFlg.....diGHWYFYNEDKDGVDPYASSAKIQDsgDS.HGKVAALVNKS..PISSWWGHNLIQRIG.VKLQPMTYRLSFYVRS-NSGAKGKLNIALKEK....DAEKCTGYALLDGFVPAD.-.....HPKSSGTTPDFTA...TTDWQLMEYVFDLSKMATTIWSPTSgtttEEEANESIANYIQEVTNEELWKNAYLIMWNETANSTLEIDNVI-f.............................
A0A3P2ACM9_9BACE/364-547             ............................NLVKEGTLE.TlDAGQ.LASTVSVPKS-E.........YVWYGMANSVKGTFD-----LLNE..QG.RGNVWCMSFAD..-KPVWYKSYLGYTSK.-GAEAAYYQLTFKARSNMPGARLQTYVRINKE....----GNHFFVLKDAD---.-.....TSKACAARM-HEL...TSEWITYVVDWDFAQTVNTIYATN-....-------IAIT---PSNTNDWNNFYLAFASQTEGAEYYIDDIT-f.............................
Q89ZG6_BACTN/21-230                  ............................NLIKNEKFA.T.EVTN.KVTNPSKATA--.........GEWFIMNNEADGVTT-IAWEQTGD..AK.YPNAMKIDNSGaeKNTSWYKAFLGQRIT.DGLEKGIYVLTFYAKAKEAGTPVSVYIKQTNEekndNGKLNTTFFMRRDYDA-D.A.....QPNASGAQYNFKIk.dADKWTKVVVYYDMGQVVNAISSKK-....-SNPALEVSDT---DDDAAILKDCYVAILGQNKGGVVEISDVTL..............................
R5VDU0_9BACE/21-220                  ............................NLVKNGNFD.T.PLNN.EKTYASIPST--.........EDWFAFDKTNGATTI---SPATDD..EK.HGNAVQIETTT..-DNSWYKAYLGQRIQ.-GAEKAVYTLSFDMKALTDGAQVRFFIR----....DAKTDNLFIMREGFDLSDeS.....TKNQSAAAYSRVIk.kAGRWSKVSASFDFSKTVNAFASIKG....VESKGGTVTEA---PVSDATLGDFVIVIQLQTKDSKALIDNVSL..............................
R6FEB6_9BACE/317-488                 ..........................ey--VVNGGFE.T.DLDA.SMQPKVGPRSDIeglnavnfvNRWWVLNHNNAALTI---DKTTGA..DD.SNHSLKYTNSK..-LDNWWSTDMSMCLQ.-GVPAGKYVLSFWAKSSQTTAPLAVNLALCET....EEDMKPTYKEWKALVKEN.GktlikKKNGNGDLYCLTSetvGTEWKQYSVTLDI------------....--------------------------------------------panil.........................
A0A174FYL3_9BACE/21-230              ............................NLIKNEKFA.T.EVTN.KVTNPNKATA--.........GEWFIMNNEADGATT-IAWEQTGD..AK.YPNAMKIDNSGaaKNISWYKAFLGQRVT.DGLQKGIYVLTFYTKAKEAGTPVSVYIKQTNEekndNGKYNTTFFMRRDYDA-D.S.....QPNASGAQYNFKIk.dADKWTKVVVYYDMGQVVNAISSKK-....-ANADLEVSDT---DDDAAILKDCYVAILAQNKGGVVEISDVTL..............................
W4P8U4_9BACE/1-139                   ............................---------.-.----.------------.........------------------------..--.-----------..---------MGQRVT.KGLERGVYVLTFYAKADKEDTQVGVYIKQTNEekneAGKANTTFFVRRDYDA-D.A.....QPNASGAQYNFKLk.sAGKWTKVVVYYDMSQVVNVINSKK-....-ANPNLEVTDT---DDDAAILKDCYVAILAQGKGAVVEVSDVSL..............................
W4P8Y5_9BACE/21-92                   ............................NLINNGKFE.T.EVTA.KVTNPNKANE--.........GEWFVMNNETEGATT-ISWTKTSD..TA.YPNAVKMDNSG..A--------------.--------------------------------....------------------.-.....-------------...-------------------------....--------------------------------------------rkifrgtrlsw...................
I8XTY0_9BACE/325-519                 ............................NLLKDSGFD.S.NPD-.-LTLLTEESSEC.........GKWLAYKDEQYEQNI-VTMAVEND..AD.QGKVVSISGKP..--YSWYTTVLSQRIE.GTLPEGIYRISFRGKS-ADGGSVRVYARATDD....KNVNINRFFVKETGRPSD.P.....EQKWYGTWQSFSL...TNQWKDYYVDINLSRIAGSMYQFT-....-EADVNSA--------TEIDRTNLNICILGNTDKATAYIDDVT-f.............................
R6D7Y9_9BACE/21-230                  ............................NLIKNEKFA.T.EVTN.KVTNVNKATA--.........GEWFILNNEADGVTT-ITWEQTGD..AK.YPNAMKIDNSGaaKNTSWYKAFLGQRVT.DGLEKGIYVLTFYAKAKEAGTPVSVYIKQTNEekndNGRYNTTFFMRRDYDA-D.S.....QPNASGAQYNFKIk.dVDKWTKVVVYYDMGQVVNTMSSKK-....-ANADLEVSDT---DDDAAILKDCCIAILAQNKGGVVEISDVTL..............................
I8XTY0_9BACE/1-97                    ...........................m---------.-.----.------------.........------------------------..--.-----------..---------------.---------------------------RLTDA....DGKDIQKFFIKETGKPAD.P.....ASKWYGSYYNTSL...TSTWTEYSVEFDFTKTIGSMYSFP-....-------TSDA--TDANEVDRTNFSICFQGDVADKTILIDDVKL..............................
A0A174WVU6_9BACE/21-230              ............................NLIKNEKFA.T.EVKT.KVTNANKATA--.........GEWFIMNNEADGATT-IAWEQTGD..AK.YPNAMKIDNSGaeKNISWYKAFLGQRVT.DGLEKGIYVLTFYAKAKEAGTPVSVYIKQTNEekndNGKYNTTFFMRRDYDA-D.A.....QPNASGAQYNFKIk.dADKWTKVVVYYDMGQVVNAISSKK-....-SNANLEVSDT---DDDAAILKDCYVAILSLGKGGVVEISDVTL..............................
R6DIY2_9BACE/67-229                  .....wlyrvmneletgdvkveldkaln---------.-.----.------------.........------------------------..--.-RNVIRCDFYQ..-QKSWYGTYLCYRTKnQEMQRKVYRLTFKAKG-TSGNNMKVIIV--GN....NGKECVITARKSE-----.-.....-SETPAGYKQINL...KKDYTEYALDFDFSQKVKAPYPYP-....--DGNGELGET-----SDETLTNFFIMFSPNSEFTKFVLDDVKL..............................
R5IQY0_9BACT/15-210                  ............................NWLSNGDFE.A.SDKT.LERFTSAATPAK.........GDWAIYGQN--GTDAFTGVLKHED..DT.YKNVAEITGSG..-SVSWYKAYLMQNVQ.YPLKAEKFQLVFDAKNVSGNTNISAWIYLGGG....-----NTYALKTDFDDKG.G.....TSTASGARYDFTG...TSEWQTFTADFDFTYQCNNINAPK-....------SVADWAKTATTTSDLADARVVFGTNAKTGAFLIDNVRL..............................
U2HVY7_9SPHI/22-218                  ............................NLIVDGKFE.Q.SSFSvNDINRKIPGA--.........GKWFPYLTS----DKQAVMSVIKD..TE.KGNAASIQTLS..-SVSYAYSFIGQRVD.KAPAAGIYTVTFWAKA-THEVPTYFGIYIKAN....APKGQTLYFPLQGFDPQE.-.....TPSRSGALRQSRI...TNEWKEYSVDFDLSKVVNAVASPK-....--VAKEDVVLS---ASTDEHRKLFDLSIACMTKNSGMLFTDVSL..............................
A0A6M1N2T8_9SPHI/22-218              ............................NLITDGKFEdA.SFSV.SDMSRRIPGP--.........GKWFPYLTS-DKQ---AVMSVVKD..AE.KGKVASIQTLS..-SVSYAYSYIGQRVA.KAPAAGVYTVKFWAKA-THDTPTYFGVYLKAN....AGKGETLFFPLAGFHPQE.-.....TPAQSGGLKQARL...SNEWKEYTIDFDLSQIVNNVAAPR-....IAKAEIILSKA-----ENNHRQTFDLGIACMTKNSGMLFTDVS-m.............................
R5JIK5_9BACE/44-237                  ............................NLIKDSGFD.N.ADFT.K-VFDAEPYL-Y.........GEWLTYKDAKE-TNV-TSYDIVDD..QE.RGKVGSFTGKP..--YSWYTSFFAQRIE.TVAKKGIYKLSFWGKS-TDGGKAKVFIRLTDA....NGKDVQKFFIKETGKPAD.P.....SSKWYGSYYNTSL...TSTWAEYSVEFDFTKTIGSMYSVP-....-------LSDA--VDADETDLTNFSICFQGDVADKTILIDDVQL..............................
R6DAM7_9BACE/321-500                 .................yglndplgkmg---------.-.----.-----------E.........GTWFYTRNNATPDESLLKSVVERD..EI.IGHNVIHTTYI..DKKSWFTYYMGYRMK.-NAKRTKYRITLKVKG-TDGKNLRCFIQNANG....--TDLNT----AVFVASD.-.....-KTGSGGYNGFRQvnlKDTYQVQTLDFDFSKMVKDPFGHTA....DES---------R-------------------------------eatdkaladfyigfgynsvanldfyiaeis
A0A3L7Z3P1_9BACE/21-230              ............................NLIKNEKFA.T.EVTN.KVTNANKATA--.........GEWFIMNNETDGATT-IAWEQTGD..AK.YPNAMKIDNSGasKNISWYKAFLGQRVT.DGLEKGIYVLTFYAKAKEAGTPVSVYIKQTNEekndNGKYNTTFFMRRDYDA-D.S.....QPNASGAQYNFKIk.dADKWTKVVVYYDMGQVVNAISSKK-....-ANANLEVSDT---DDDDAILKDCYVAILAQNKGGIVEISDVTL..............................
I8XTY0_9BACE/113-307                 ...........................e-LIKDSGFD.K.AD-F.TKTFDATPII-F.........GEWVTYKDPKNEKNE-VSYAIIDD..AI.KGKVASYTGKP..--SSWYTSFFAQRIE.TTAKKGIYKLSFLGKS-TDGGKVKVYIRLTDA....GGKDVQKFFIKETGKPAD.P.....ASKWYGSFYSTSL...TTEWVEYSVEFDFSKSINSMYSVP-....-------LSDA--VDTDEIDLTDFSICFQGDVADKTILIDGVSL..............................
#=GC seq_cons                        ............................NLlcstpFt.s.psp..p.p..shsss...........GcWahhpsptpttst.hshthhsD..sp.hspshphssps...thSWYpualuQRlp.tshpcGlYpLoFhuKu.psGs.lpVaI+.ssp....suK.sspFFh+cshcs.D.s.....psstsGuhYshpl...sscWpchsVpaDhopsVNuh.Shp...........plo-s...sssst.Lpsh.lshhspscsush.IsDVoL..............................
//