#=GF ID   DUF473
#=GF AC   PF04322.16
#=GF DE   Protein of unknown function (DUF473)
#=GF AU   Waterfield DI;0000-0003-2885-5126
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   COG1935
#=GF GA   25.00 25.00;
#=GF TC   82.40 82.00;
#=GF NC   22.10 20.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR007417;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Family of uncharacterised Archaeal proteins.
#=GF SQ   51
#=GS Q12XF8_METBU/1-118       AC Q12XF8.1
#=GS F2KMZ2_ARCVS/1-118       AC F2KMZ2.1
#=GS A0B735_METTP/1-118       AC A0B735.1
#=GS Q8TWN5_METKA/1-117       AC Q8TWN5.1
#=GS C6A056_THESM/1-115       AC C6A056.1
#=GS A0A2V3JPJ6_9EURY/1-118   AC A0A2V3JPJ6.1
#=GS L0HDJ1_METFS/1-122       AC L0HDJ1.1
#=GS I7LIP5_METBM/1-118       AC I7LIP5.1
#=GS Q0W0N3_METAR/1-118       AC Q0W0N3.1
#=GS A0A0F7IFC7_9EURY/1-117   AC A0A0F7IFC7.1
#=GS L0KV02_METHD/5-122       AC L0KV02.1
#=GS D5EAK6_METMS/1-118       AC D5EAK6.1
#=GS F0LKL9_THEBM/1-115       AC F0LKL9.1
#=GS F6BD12_METIK/1-115       AC F6BD12.1
#=GS Q8THU7_METAC/1-118       AC Q8THU7.1
#=GS A6UT47_META3/1-116       AC A6UT47.1
#=GS B8GFL2_METPE/1-119       AC B8GFL2.1
#=GS D7EB45_METEZ/1-118       AC D7EB45.1
#=GS A0A0E3L5R0_9EURY/1-118   AC A0A0E3L5R0.1
#=GS W9DY57_METTI/1-118       AC W9DY57.1
#=GS A0A8J8B6I0_9EURY/1-118   AC A0A8J8B6I0.1
#=GS D1YYL8_METPS/1-118       AC D1YYL8.1
#=GS A0A1F2P8Z9_9EURY/11-129  AC A0A1F2P8Z9.1
#=GS D2RGW2_ARCPA/1-118       AC D2RGW2.1
#=GS Q5JEQ4_THEKO/1-116       AC Q5JEQ4.1
#=GS A0A1Q6DTC7_9EURY/1-120   AC A0A1Q6DTC7.1
#=GS A0A062V9N8_9EURY/1-118   AC A0A062V9N8.1
#=GS D3RXD4_FERPA/1-117       AC D3RXD4.1
#=GS Q8PXW9_METMA/1-118       AC Q8PXW9.1
#=GS A0A0X3BHA9_9EURY/4-121   AC A0A0X3BHA9.1
#=GS A0A2V2N8T6_9EURY/1-120   AC A0A2V2N8T6.1
#=GS Q2FPW2_METHJ/1-120       AC Q2FPW2.1
#=GS G7WQB5_METH6/3-120       AC G7WQB5.1
#=GS F4BUT8_METSG/1-106       AC F4BUT8.1
#=GS A0A8J7UNZ2_9EURY/1-119   AC A0A8J7UNZ2.1
#=GS A0A1Y3GAS9_9EURY/1-119   AC A0A1Y3GAS9.1
#=GS Q8U4R0_PYRFU/3-117       AC Q8U4R0.1
#=GS A0A498H507_9EURY/1-119   AC A0A498H507.1
#=GS F7XNM2_METZD/5-122       AC F7XNM2.1
#=GS N0BLV8_9EURY/1-118       AC N0BLV8.1
#=GS Y105_METJA/39-149        AC Q57569.1
#=GS A0A483CQ91_9EURY/1-121   AC A0A483CQ91.1
#=GS A0A2V3JRW3_9EURY/2-78    AC A0A2V3JRW3.1
#=GS E1RI98_METP4/1-119       AC E1RI98.1
#=GS Q6LYS5_METMP/1-115       AC Q6LYS5.1
#=GS A7I9N2_METB6/1-121       AC A7I9N2.1
#=GS O29018_ARCFU/1-117       AC O29018.1
#=GS A0A4E0Q0I8_9EURY/5-122   AC A0A4E0Q0I8.1
#=GS H1YWK3_9EURY/1-119       AC H1YWK3.1
#=GS D7DU20_METV3/1-114       AC D7DU20.1
#=GS A0A8J8C0W2_9EURY/21-132  AC A0A8J8C0W2.1
Q12XF8_METBU/1-118                  ..MEYAALTGISDTVISELKGHLLRTIEIRSPQNFFTSLD.FDVN..DHIFLTRTSAQDIMRGTSGVVAQVVKHHVSTHKMITGND..TFYEEYESMIIRLQLKPIGVARIN.NIISNELGKVTLV..........
F2KMZ2_ARCVS/1-118                  ..MRCYVLTGISRKTLEDLVKRNIRAIELRSAHNVATALK.ADIG..SCVFLTPSKLYNVGRGTTGIIAEVSGKEVMSHSIIFASN..HYIEESEMTVVRLRLTPRSVGRIV.TVYNADILDST--ea........
A0B735_METTP/1-118                  ..MICVALTGISRNVIKDLVNNRVRTVEIRSPLNFFSLRG.VNPG..DRIFVTEASLKDIVNGTPGVIARVNEIQIMTHRMIQSND..FFYEEIESQAARAQLQFLGIGRVR.RINTIEPYEPFV-i.........
Q8TWN5_METKA/1-117                  ..MKMLAITGVSFRVVEQLLTQGSTQIIVRSGNNLDAVVR.LQPG..DLVFVTTVGKRELKKGVSGVVATVRSVSVVHEHVVTGGD..-EHFEREFVAARLILNRVGSGRVR.EYKDCGVGRRVEV..........
C6A056_THESM/1-115                  ..MDLLVLAGISRKTLDQLLRNPYRTIEIRSARNVIAIQS.LKLG..ERVFLTYETLQDITQGTEGIIAEVLKIERMEQRIPWEES..---DEREQTICRLQLRLKGLGKVI.EISTEGEVVK---arv.......
A0A2V3JPJ6_9EURY/1-118              ..MRCIALTGISNRVINDLKSRLLRTIEIRSPHNFSGVLH.IDVG..DPVFVSSTSPNDVTAGTTGLIARLQRRDISIHRVVQSND..FFYEEREAMMARIQLVAEGSGRVQ.RIINSELGSALV-v.........
L0HDJ1_METFS/1-122                  ..MKCAALTSISPDIIKELKSGRPRTIELQSTHNIVTVAE.VEPGpdTHIFMTSTDVEDLSPGDAGICVFVLSTSLSMKRVVEFSQggTMYEERERVSARVQVKFCATSVIK.GVYRDGLMKPTKV..........
I7LIP5_METBM/1-118                  ..MKYAALTGISPSVIAELKGGKARTLELCSAHNIITLTE.AAPG..ECIFMTSVNEEDLAPGDPGIMVDLLVLSISMKRVEVVNP..LFIEERERMSARIKVQFRGTTIAR.DVEGRKWGDPTKV..........
Q0W0N3_METAR/1-118                  ..MKIAAITGLTQESLQDLRRRRIRTFEIRSAHNLQAFSE.IGPG..DKVFLTDVALPDLVPGLCGCIAMVKGVDIRMHRMTYTTQ..SNIEERETLSGRIQLILHSTGKVR.DVYPVEVYKPIYV..........
A0A0F7IFC7_9EURY/1-117              ..MRCYIISGISRQVIEEILRGNLRTLELRNVINVATALN.TKLG..DCVFITTAKNVDLGRGVTGIIAEVEGKEIVSHSTFFARN..DYFEECEMTVVRLRVRPKALGRLV.QVFRKDLLSPV--e.........
L0KV02_METHD/5-122                  ..MEYIALTGMSERVISELRNHHPLTIEVRSPNNFFAAYK.AKIG..DFIFVTHVSPDDLRGGAMGIVAKVLKHQVMTHRMVQSND..LYYEEREMTMLRIQLEPRFIARVR.RVTCNQMCKAAKV..........
D5EAK6_METMS/1-118                  ..MEYVALTGISHDVVTDLKNHGLRTIEIRSPHNFFTTLN.LNVG..ENIFLTSTSTQDLTAGTKGIIVKLMKHQVSTHRIINGTD..NFYEEREMTMIRIQLKSKCVARVR.KVLSNQIGQITLV..........
F0LKL9_THEBM/1-115                  ..MEVLILAGITRRTLDQLLRNPYRTLEIRSASNVFVLEH.LKEG..DRVFLTYETLQDITKGTEGIIAQILRMEKMEQRILWEES..---DEREQMVCRVQLRLVGLGKVI.EIRREG-------dlikarv...
F6BD12_METIK/1-115                  ..MRIIALAGISPHALSELIKNHIKTLNLKSADNLLALKS.VDVG..DFVFITSVVKDDIIPGTEGIIGRIRKISIIHQKTPPEVS..---EERECVVGKVQIEMIGFGTCV.DIAEMEVLSPL--il........
Q8THU7_METAC/1-118                  ..MEYIALTGIADSVIEILKKHELRTLEIRNPQNFFGVLG.LNAG..DSVLLTSTSLQDLTDGTSGLIAKVIQKEISVHSFVSSND..LYIEERETLSARIQLECRHMARVR.SVISNEIGKPVRV..........
A6UT47_META3/1-116                  ..MKVVVLTGIAPEGISKLVNNHLYTFNLKNFTNIIAITSsLDIG..DFVFLTEMPKEDTIPGTEGVIAQIKSLKIVTQKEKLPYN..---EETEYVIAKIQLEVVGYGACV.EIMDSKELLPI--ta........
B8GFL2_METPE/1-119                  ..MKCAALTGISAEVIKELKRGRPRTLEVQSAHNVITVSG.VDPG..SHLFMTDVDRDDLAIGDNGIIVDVLSIGITMKRIIEFSY.gSHFEERERMAARIQVRYCANSSVK.EVSPLETIQPTTV..........
D7EB45_METEZ/1-118                  ..MEYVALTGIAENVMRELKNDTLRTVEIRSPHNFFTALK.LNVG..DFVFLTHTSIQDLTSGTTGVVARIMKHQISTHRTFSSTE..TFYEERETTTARIQLDPRASARVR.KVHSNDIGEITRV..........
A0A0E3L5R0_9EURY/1-118              ..MEYIALTGIADSVIEALKTHSLRTLEIRNPQNFFGVLG.LNAG..DQVLLTSTRRDDLTDGTTGLIARVVQRQISTHSIISAND..LYIEECETMAARVQLECRCMARVR.SVISNELGKPVVV..........
W9DY57_METTI/1-118                  ..MEYIALTGISERVISELRQNRLLTIEIRSPNNFLAALR.MNVG..EMLFLTHTSAEDLTGGSMGIITKLVRHQVSTHRVMQSNE..AFYEERETTSLRLQLDPNCIARVR.KVLNNTIGEVTKV..........
A0A8J8B6I0_9EURY/1-118              ..MMVAALTGISPQVIADLKLGKPRTIELQSAHNIITLSE.VNPG..DHIFLTSIAAEDLSPGDSGLILTVQAVSISMKRVIEYSH.gHHFEERERTSARVQLKYCGTSIVK.ES-----------galscckayy
D1YYL8_METPS/1-118                  ..MRLLALTGLSKESLSELSKRHVRTFEFHSANNVIAFSH.LNVG..DTVFLCEVPPADLTPGLCGAIATIKGFDTHMQHVYYASS..SHHEEMETMSARAQMGFISIGKIK.KVEMGGLYEPVYV..........
A0A1F2P8Z9_9EURY/11-129             mt-KYLTLSGMRRSVMEELARDRLKTMQITSPHNFFAIMK.LNTG..DLVFLTDESPEDVNRKTQGIVAQVRSRQISMQRFYHVDA..SGSEEREVLSARLQLEKKFVAIVK.VVEHGDLGMPMI-v.........
D2RGW2_ARCPA/1-118                  ..MKCLVLTGISKDVLDDLMRRHIKTIELRSAHNIATAMR.AEVG..DCVFLTSAKTFDVDRGTLGIIAQVTGKEIYSHSLMFSTP..TLIQESEMTVVRLKLEVRGVGRVV.RVYNTGILDTT--ea........
Q5JEQ4_THEKO/1-116                  ..MEAVLIAGIARRLLDELLRNPYRTIELRSARNVLAVERaMEDL..RRLFLTYEPFEDVRTGTEGLITELIEARELNMRVPWEES..---DEREVTVCRARVKLLGLGRVV.EMERRDSITVVKV..........
A0A1Q6DTC7_9EURY/1-120              ..MEMKVLTGIAKPVLDELMESGTRTIEFRSAHNINSIID.ISIE..EKVFLTNKKKDDICKGTNGIIIDVQKKNISMHHVSYSSN..SIYEEHETTIARLKTKLKGLGTVK.NVKKSER------kegiiaei..
A0A062V9N8_9EURY/1-118              ..MQYIVFSGISQHVLKSLEQDKIKTIEIRSPHNFLSALE.TDIG..DVVFLTSTSLGDIRPGITGIIAKIREKQISMHRMVQRTE..DFYEEAEVQMARLQLELKGYARVR.RAICCAIGEAA--iv........
D3RXD4_FERPA/1-117                  ..MRCWILTGISRRVIDDIISGYTRTIELRSAHNVSIAMK.AEVG..DCVLLTPARFYELDRGIVGLIAEVVGKEVHSHSIVFAKE..GFVEESEMTAVRLKLKPRGIGRVV.AVKKKELLGE---ve........
Q8PXW9_METMA/1-118                  ..MEYITLTGIADSVIEILKKHDLRTLEIRNPQNFFGVLG.LNAG..DSVLLTSTSLQDLTDGTQGLIARVVQKQISVHSFVSSSE..LYIEEREALSARIQLECRCMARVR.NVISNEIGKPVIV..........
A0A0X3BHA9_9EURY/4-121              ..MKYAALTGISPSVIAELKGGKARTLELCSAHNIITLTE.AAPG..ECIFMTSVNEEDLAPGDPGIMVDLLVLSISMKRVEVVNP..LFIEERERMSARIKVQFRGTTIAR.DVEGRKWGDPTKV..........
A0A2V2N8T6_9EURY/1-120              ..MECITLSGISPQVIEELRKGVPRTVELTSAHNVIALST.VAPG..ARVFMTSVDCEDIVIGDTGIIVEIQSVSITMKHVVEVSQ.gYHVMERERMSARCKLKYISNTTIKaTVSPCRLTEPR--rv........
Q2FPW2_METHJ/1-120                  ..MECIALTGIFPQVIEELKKGIPRTIELTSAHNVISLTQ.VTPG..SLIFLTTVDCEDVTVGDTGIIAEVISVAITMKHTVESGS.gYHIMEREKLAARVKLKFLSKTTIRaNVTRCSITEPRI-v.........
G7WQB5_METH6/3-120                  ..MECVALTGISRPVIRELLTNGIRTLEIRSPGNFLALLQ.TNPG..DVIFLTEASGPDIVAGTGGMLTRVREIQVVTHKVVQAGA..DFYEERESQAARVQLVIVGHGRVR.RVKSLKIGSPTV-l.........
F4BUT8_METSG/1-106                  ..------------MIKEILAARVRTVEIRSPNNFFAIYN.CQPG..ERIFITDSSALDVVPGTTGLITTIKALQVITHRTIQSGE..NYYEESESQAARLQLQLVGVGRVR.RIASIEPATP---ltl.......
A0A8J7UNZ2_9EURY/1-119              .m---TALTGISGPVLNELKMGKPRTLELQSAHNVISIAS.LEPGpdTYLFLTNVDLEDLSPGDVGIIARVLSVSVSMKRVVDYIH.pVYYEERERLTARVQLRSCANSMVK.TVRTGPICQPIEV..........
A0A1Y3GAS9_9EURY/1-119              ..MKMKVLSGIAQPVLDDLLRDGTRTIELRSANNIMTIFD.QKPG..DYILLSDKKRDDITRGTNGIIAKIKNKKISMHHISYSTN..SIYEERELTIARIKTQTAGLGTIK.QIIKQT-------pqgittev..
Q8U4R0_PYRFU/3-117                  ve--IPLLSGIARRTLDALMRNPIRTVEIRNARNYMTLEK.VKEG..DLVFLTYESLEDVMRGTEGIIAMVTRMEKSHQRVPWEES..---DEREISICRVQLKLVGLGRVV.EVQEKNGVVFVK-v.........
A0A498H507_9EURY/1-119              ..MMCTALTGISPSVIAELKNGKARTIELSSAHNIISLTE.ASTG..ECVFMTSVDQDDFSEGDPGILVDLLALSISMKRLVEFVN.pAYFEERERMSARIKVRYAGSTLAR.GVEGQDWGKPTKV..........
F7XNM2_METZD/5-122                  ..MNYVALTGISENVVRQLRDNVLLTIEIRNPKNFYSALK.LNVG..DYVLLTSTGAEDVRKGTAGIVCKVMKHQVSTHRMVQANG..MFYEEREMTMARLQLNPKGSARIT.KINSNGLGEVSCV..........
N0BLV8_9EURY/1-118                  ..MRCFVFTGISRVIIEDVIKGMVKTIELRSAHNVATALK.ANVG..NCVFLTPTRLYDLSRGVSGLVAEVTGKEVISHSIFLSTD..RFMDESEMTVVKLRLKPKCIGRIL.NVLNAGILDST--ea........
Y105_METJA/39-149                   ..MKVYGLFGINENAINDFIENHIKTFTIINALNLETVKN.LKEG..DLVFITSTLREDLRNGTEGILGRVINVSLVPQMI-----..NGFEEKEIIAGRVQLEMLGFAKCV.KYESI--------hveitf....
A0A483CQ91_9EURY/1-121              ..MKITALTGIAGAVINEIKMGKPRTIELQSANNVISVAS.LEPGpdTHLFLTSVDLEDISPGDVGIIVRVLSVNINMKRVIDYIH.pVYYEERERLSARIQVRYCGTSMVK.GVEIGSICHPVEV..........
A0A2V3JRW3_9EURY/2-78               ..MRCIALTGISNRVINDLKSRLLRTIEIRSPHNFSGVLH.IDVG..DPVFVSSTSPNDVTAGTTGLIARLQRRDISIHRA-----..------------------------.-------------v.........
E1RI98_METP4/1-119                  ..MKIAAITGISPNVIAELKKGKPRTLELQSAHNIITLTD.VLPG..DHVFMTHIDLDDVCSGDPGIIVEVLSITINMKRMVEYIN.pYYYEEKERMSARIQVKYVDNTIAK.GVDGRYWAKPTVV..........
Q6LYS5_METMP/1-115                  ..MKALALTGVGPYAISEIVKNHVKTLNLKNICNLLALES.LNVG..DFLFITNVSKEDVISGTEGLIVQVKNISINNQNGYSRSC..---DEIESIVGKVQVELLGYASCS.NVVETGLMDPSVV..........
A7I9N2_METB6/1-121                  ..MKCAALTGISPDLIRDLRAGRPRTLEFQSTQNIITIAN.IDAGpeAHIFLTSIDAEDLGPGDAGICVEVLSSSISMKRVVEYAQ.gIYYEERERMSARVQVKYCFSSTVR.EVFREKLCAPTFV..........
O29018_ARCFU/1-117                  ..MKCLVLTGISRNVIEELMRRNIRTIELRSAHNVATALK.AEPG..DCVFLTPARINDLGRGVSGLVAEVRGKEVMSQSLFYQSP..SYIEESELTVVRLMLKPKSLGRLV.QVKRGAFLETI--e.........
A0A4E0Q0I8_9EURY/5-122              ..MEYVALTGLSERVIAELKQNRLLTIEIRSPHNFFAAMN.LAVG..EFIFLTRTSPDDLTGGTTGIVARLLKHHVSTQRVVQNSE..MYYEEREMTILRLQLDPRCIARVR.KVLNNKMGEVSKV..........
H1YWK3_9EURY/1-119                  ..MIVSALTGISPNIITELKKGKPRTLELYSAHNIITLTE.ILPG..DHIFMTDVDLEDVCTGDRGIIAEVQSINITMKRVTEWIN.pLLCEEKERMSARIKLKYIDMALAK.RVEGREWAKPTSV..........
D7DU20_METV3/1-114                  ..MKTLAITGISKGGLSELLKNQVRTFVLKNVANYSVLTN.SEIG..DVLFITSIHKSDLTVGTEGVIAKLISMDICNNINYEEKA..---DENETVVINAQFEFLGYAVCL.DVAESEEY-----piiq......
A0A8J8C0W2_9EURY/21-132             .n--MPAVTGISNKMYELLFQRPLLSLEIKSADNVSSLLS.AEQG..ATLFLTPVLREDIMPKAEGMICELKDKKVTLQKV-----..KKWDEIELVAVRIQVKPVCIGRIK.TIEKRHLGEGVEV..........
#=GC seq_cons                       ..MchhALTGISppVIp-LhpsphRTlEl+SscNlhslhp.lssG..DplFLTssshpDlssGssGlIucVhphplsh++lh.tss...ahEE+EthsuRlQLchtuhupl+.pVhspphhpss............
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