#=GF ID   DUF5108
#=GF AC   PF17133.8
#=GF DE   Domain of unknown function (DUF5108)
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   JCSG:gi|29349574-PHMMER
#=GF GA   27.40 27.40;
#=GF TC   27.40 27.50;
#=GF NC   27.00 27.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR033401;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This is a family of Bacteroidetes proteins. The domain lies
#=GF CC   upstream of a Fasciclin family, Pfam:PF02469.
#=GF SQ   29
#=GS R5YIG1_9BACE/377-597      AC R5YIG1.1
#=GS I8XRV2_9BACE/336-516      AC I8XRV2.1
#=GS A0A0B8T2K9_9SPHI/390-535  AC A0A0B8T2K9.1
#=GS A0A1K1QDD1_9BACT/364-524  AC A0A1K1QDD1.1
#=GS A0A1M5K2M9_9FLAO/354-550  AC A0A1M5K2M9.1
#=GS A0A2S9JM36_9SPHI/373-533  AC A0A2S9JM36.1
#=GS A0A257I1N0_9BACT/365-538  AC A0A257I1N0.1
#=GS A0A4U0P1P7_9SPHI/388-537  AC A0A4U0P1P7.1
#=GS A0A3B7MSC8_9BACT/378-542  AC A0A3B7MSC8.1
#=GS A0A1I1K5Q3_9SPHI/364-535  AC A0A1I1K5Q3.1
#=GS D7VJL2_SPHSI/397-537      AC D7VJL2.1
#=GS A0A2T5C4P2_9BACT/364-565  AC A0A2T5C4P2.1
#=GS R7CX73_9BACE/378-584      AC R7CX73.1
#=GS A0A1V9FWU6_9BACT/380-541  AC A0A1V9FWU6.1
#=GS A0A4V1M7W8_9BACT/371-545  AC A0A4V1M7W8.1
#=GS A0A4Q1DCD9_9BACT/369-536  AC A0A4Q1DCD9.1
#=GS A0A5B8UGH1_9BACT/374-549  AC A0A5B8UGH1.1
#=GS A0A0E9LT44_9BACT/373-533  AC A0A0E9LT44.1
#=GS W4UV46_9BACE/12-214       AC W4UV46.1
#=GS Q8A055_BACTN/359-579      AC Q8A055.1
#=GS A0A1V9G6I2_9BACT/383-550  AC A0A1V9G6I2.1
#=GS A0A419W668_9BACT/363-561  AC A0A419W668.1
#=GS G8TBK5_NIAKG/389-544      AC G8TBK5.1
#=GS R5JUE6_9BACE/340-515      AC R5JUE6.1
#=GS L0G2T2_ECHVK/373-532      AC L0G2T2.1
#=GS A0A1W6E5R2_9BACT/350-466  AC A0A1W6E5R2.1
#=GS R6DFY7_9BACE/363-574      AC R6DFY7.1
#=GS E5C5Y2_9BACE/357-558      AC E5C5Y2.2
#=GS A0A0L8V7H9_9BACT/363-559  AC A0A0L8V7H9.1
R5YIG1_9BACE/377-597                 ...............................................WDFCNTAEIISFVNAYGaDr.nlGALFTSALAAKEYPIdLSEDKRDGDYGNVSAFVENETYLGNSS....RASYS.NYRKig........fvkCKY...K.SAREK..DVNN..YGAYMNN-LLV...LNLG...Y...A...G...W..VQLESPTIIKGRYKVELCYAA.NPV....LYEFYA-..-....--......-.S..G.SL.T..R..FTLD..DENAS-.....SVYIYKGLTs....qGFGKA.TYGTAFTT-LWGE....-IEFENSGKHVLKATMMDINAKTSSKYHQLWDYVKFTPI...................................................
I8XRV2_9BACE/336-516                 ......................eitepkatkvtwdltdypelagvce-----------------.-....---------------.-------------------KYQLENQS....KTYTR.SLAYdilncyklsggygSDY...T.YHLAN..KNEV..MYKASNHDCMF...LNLG...K...Y...G...W..IQMESPMIIAGKYKMSLVH-Y.NQA....LKT----..-....--......-.K..E.GR.W..S..VIVD..GEYVGV.....------QVT......TWGNS.TSKSEMITTTIGE....-VEFTESIPHTVRFMAGD-------DYYSYLDCLIFEPI...................................................
A0A0B8T2K9_9SPHI/390-535             ...........................vftaneltsivwasqpetra-----------------.-....---------------.---------------------------....-----.--NV.............LTY...R.NNRSA..DGIW..YTGTLNYDHFR...VELG...E...S...G...W..MQMKSPTIVRGKYKVKLVWPS.TR-....-------..-....NA......A.S..T.GI.C..A..FVLD..NVMIYP.....-RLVLSNTS......TDRVS.T--QELA------....TVDFPETTDHTLRILSLDGKL-------LTLDYIQFDPV...................................................
A0A1K1QDD1_9BACT/364-524             .....................nyvysltnmpsgfsvpgpsamtyava-----------------.-....---------------.---------------------------....-----.----.............---...-.-----..----..-STYVNGDFLM...IPLG...G...P...GrsaY..MEMKTPLLVKGKYKVWICYRV.QKQ....SSSSNNL..N....QI......SiD..G.EV.M..Q..RTMN..FT----.....--TAMPATTeg.emeAQGWK.-WYTDPTSNSWGArlvgTIEIKTTERHTLRFTTLT---------------------gtqnnnnldmihfip....................................
A0A1M5K2M9_9FLAO/354-550             ...................fdvcdqpefaanvanyrkstgasfgipp-----------------.-....---------------.---------------------------....----G.GFAD.............ITW...T.GSKTYtlDWNN..YGGAVNGDLIRatrFRTG...S...G...G...LndIEYKTPVIIKGRYKIWVSYRA.HASgssnTKVFFNG..E....QT......S.R..IlNM.K..E..FPND..PSVVATg...iVDRVYESQGykrhifPFVK-.--GDAMVSRLVGI....-VEVTTTGRHLIKFN-TDAGTSSGSADADRIDLIEFRPV...................................................
A0A2S9JM36_9SPHI/373-533             ......................ieanvsqyrnnnlgsqynktftpne-----------------.-....---------------.----------------------LTNIT....WNAQP.EYATg...........eVVY...R.NN-RP..TEGN..WYQCLNHDHLR...AQLG...E...S...G...W..IEFKSPTIVRGRYRVSFVWPS.TR-....----Y--..-....-S......S.H..T.GI.V..A..FIMD..GQMIYS.....-RLVISNS-......---RE.--DRNLTQNL-GT....-IEFTETTDHTLRILSLD---------------------gglitmdylql........................................
A0A257I1N0_9BACT/365-538             ......................kvgksqtfalgqlkdvtwqnvnstp-----------------.-....---------------.---------------------------....-----.----.............-QY...S.TEAAT..TSNFywWDDHFDFNMRF...GNAA...A...N...N...W..IEFKTPLLVKGKYKVWVCFRR.ASV....GQYIQLS..F....DG......V.P..T.SKlI..D..LTTA.lNGALAG.....---AALEAT......GYKRY.TIVTTSNNYAMFA...gIVDVATTDRHLLRFTCVKDQGSGANN-TSTVDFVQFIPV...................................................
A0A4U0P1P7_9SPHI/388-537             .....................aqynktftaseltsikwqsvpenrad-----------------.-....---------------.---------------------------....-----.---V.............LIY...R.NNRSN..DGIW..YTGTLNWDHFR...VTLG...E...S...G...W..IEFKTPTIVRGKYRVTFVWVS.PAS....-------..-....-S......T.N..S.GI.C..S..FIMD..NQTLNP.....--RFVISNT......AEGKR.T-------QVLGE....-VDFQETTSHTLRILSLD---------------------grliildhivfdpi.....................................
A0A3B7MSC8_9BACT/378-542             ..................eldkpikdidwefksasttltyfystsss-----------------.-....---------------.---------------------------....-----.----.............---...-.-----..-LGI..Y--QYNNDCLV...LPLG...ApsrA...T...W..FEFTTPVIIKGRYKVWICYNArNAV....VCNVRVN..G....DL......M.QrpV.NL.G..E..FRPAgsDAELES....iGWKRYIEST......--GSN.S--GYYVSRLVGT....-IDIKTTERHKLRLE--TISGTNASNYLDM---IHFI--pv.................................................
A0A1I1K5Q3_9SPHI/364-535             evtdypdlaanvtqyrnpslgaqydrvfqqgelesfrwvsqpedrag-----------------.-....---------------.---------------------------....-----.---V.............LTY...R.NNRAA..DGIW..YSEVLNHDHLR...IELG...E...S...G...W..IEMETPVIVQGTYRLTLVWPS.PRQ....----A--..-....--......N.P..T.GI.C..A..FALD..GQMLRE.....-RHTISNTS......SDR--.----VLTE-TLGT....-VTFEETTSHTLRVISLDGRL-------ITLDYIRFEPI...................................................
D7VJL2_SPHSI/397-537                 ...............................dlksiiwsarpetrsn-----------------.-....---------------.---------------------------....-----.---V.............LIY...R.NSRPA..DGIY..YSDVLNYDHLR...VTLG...E...S...G...W..IEMNSPVIVKGKYKVTFFWPS.P--....---IQA-..-....--......T.S..T.GI.C..S..FILD..GVLMR-.....---------......-----.-------------....---------------------------------------dkhtisntrtdrqleqslgnvtfeettshklrilsldgklitldyirfdpi
A0A2T5C4P2_9BACT/364-565             ...............................................WDLTNYSDIASSINDFG.AvrglGECYQQAQEGNSYKI.TLWN---------DEIQSYNWNVIGSK....RSSWP.TVGYf...........lAQE...S.EDDED..DLEN.vYGA-NLNDFLI...LSLG...H...F...G...T..VEMKTPVLAKGRYRVELYYGY.DAS....LADFIE-..-....--......-.G..G.SQ.C..Q..FVVD..DD-IS-.....----YKYLY......SGIDN.TIGTYSIA--LFD....NIEFATTQQHNLEITLLDSRAQSHNAYRLMLDYVKFIPI...................................................
R7CX73_9BACE/378-584                 ...............................................FDVTNYEEIKNWIEA-G.N....GDFEEMKYQTTHETT.EGNA-------DVSTLGLYDFSLNNPSpwrpGSSKP.SWFV.............IYF...T.S---K..SNND..WKNAQNHDMLM...LNLG...T...N...G...W..ISFTTPVIVKGKYKVSIQFGN.AKS....MDFIANA..T....NG......S.N..G.GQ.M..E..FSID..DQNVTS.....---AYPYTS......PDVHK.G-GSYLFSYVVYD....EIEFTSTSTHTFKLVMKDPAASTNSNYRFMIDYILFEPI...................................................
A0A1V9FWU6_9BACT/380-541             ....................................kditwnagtve-----------------.-....---------------.---------------------------....-----.----.............-YY...CnTPGAK..DLFY..WNDRLNFQYLK...TTSG...N...M...N...W..VELTTPLIIKGRYKVWVCWRA.NGG....ITGLGMQ..T....-W......I.D..G.VL.M..PrlWSFG..DYNYGKylteaEVQAAGWKR......YYVGA.STADHMASKLVGT....-VEITTTGRHKIKFVTTEVSPKTQGCWLDMIHFI-----pe.................................................
A0A4V1M7W8_9BACT/371-545             .....................nftrateadnpikdhywgwgplastn-----------------.-....---------------.---------------------------....-----.---T.............LTY...T.YSAAS..SITN..YA--YNADINM...LPLG...L...PnrpP...W..WEMRTPPIVKGKYKVWVCYRQ.QKQ....SSSSNML..C....QV......SvN..G.TI.M..Q..RTMNftDTRPAG.....---TDSELE......AIGWK.RY-TENTSNLWAArqvgVIEFTTTKQQLIRITAL-----TGTQNNNNLDMIHFIP-i..................................................
A0A4Q1DCD9_9BACT/369-536             .......................................gqvqeftd-----------------.-....---------------.-------------------------PD....QFSGI.NWSGg...........sIKY...N.VT-AT..SSSD..YYCYYDFISLY...MRTA...V...T...P...W..IEFKTPFLVKGKYKVWVCFRR.ARA....QTIQVQV..D....DQimprliS.V..A.DY.Y..P..VALD..DDNAEA.....----AGFKR......FMVTA.ASNSNHIGKLVGT....-VDITTSQQHTIKFIALTNESGSANTFN--LDMVHFIPI...................................................
A0A5B8UGH1_9BACT/374-549             .............................rqsesdqpfkemtwgwgs-----------------.-....---------------.---------------------------....--LAStNIFT.............YYY...N.SSSSN..SITG..YGA-QNNDAIN...LPLG...L...ParpT...Y..WELTTPPIIKGKYKIWICYIQ.RKQ....SSSSNNL..NkvsvNG......D.D.lP.NT.M..N..FTVT..RPSGTDa..elEAINWKRYT......ESTNA.IYAGRMVG--VYD....---FKTTQRQTIRFT--NLAGTQNDNYLDMIHFI-----pvd................................................
A0A0E9LT44_9BACT/373-533             ..............hyrrsgltstyreyieqgsvqsyeweaipsdrv-----------------.-....---------------.---------------------------....-----.---Nl...........aVSY...Y.VANRN..DAVP..YG-MMNHDALV...FQGG...L...Y...G...W..IEMETPAIVKGTYDLKVRYYS.INS....ATRYGK-..-....--......-.-..-.--.F..L..TILD..GTYLGS.....-EIATHGSS......---ST.--TARLQTTTIGR....-VTFEETAPHVLRILASD-------NFAVYLDYFEFVPV...................................................
W4UV46_9BACE/12-214                  ...............................................FDFCNYPVISSYIAA-G.K....GTAG-QAYQT---AT.TSNE----YRTNVMSLSCYNVMLGPSG....PASTS.SWNE.............VDY...F.TV--K..TGNA..FKNCKYNDMLV...LNLG...Y...L...G...T..ISMKTPALIAGKYKVTLYMGY.STS....MNFIRTM..G....SG......S.N..G.GE.M..I..FSFD..NEDAT-.....--KIYTKPF......TEVSA.N-TLGVYSAVVYE....ELEFAKTGAHTFKIVINDPTASTNSNFRMQLDYLLFTPI...................................................
Q8A055_BACTN/359-579                 ...............................................FDFCDYPEVSSYIAAKG.K....GQLYQQVSRDDDDTY.TALTKFIGRQEIVPQVSSYKIEM-GPS....GTLAS.DWSY.............LSY...C.TKGAN..TSGN..WTKLMNNDALV...VNIG...Y...N...G...T..LDLTIPPILAGKYRITLYYAY.DPS....MKFIGER..G....EG......S.Q..A.GL.T..N..FRLD..SKRLAGg...dNKRIYDGKT......GDVQD.CFNTPLTSNLSGEe..tAFEFTTTASHTLNVVVVDPAASSHNKFRMYFDYILFEPV...................................................
A0A1V9G6I2_9BACT/383-550             ............................keitwgwgslastniftys-----------------.-....---------------.---------------------------....-----.----.............--Y...S.----T..TSSL..TRYAVNNDVNQ...LPLG...L...ParpT...W..WEMTTPAIIKGKYKVWMCYSR.SKQ....SSSSNNL..C....QV......SvN..G.DL.M..P..RTMNftDLRPKGs..daELEAIGWKQ.....yTEVRAyNTDSNYAGRLVGT....-YEFKTTQRQTIRIT--NLTGTQNNNFLDMIHFI-----pid................................................
A0A419W668_9BACT/363-561             ...............................................WDVCDYDDVASYVNAYG.AsnslGDIFQII-QANEYKV.TFDP---------DAVTSYEWNA--FS....SASSG.SYPA.............CGYlitK.SNDGG..VTNT..YGAYKND-MLF...VNLG...Y...S...G...N..ITMQTPVVLKGRYKVELFYAS.AGS....LSEFVS-..-....--......-.G..G.SL.C..K..FSLD..DTSN--.....EVYVYDGAS......ASVG-.IYGLTLFS-----....EIEFEASDNHQLKIVLLDPRATTSSAYRLQLDYIKFTPI...................................................
G8TBK5_NIAKG/389-544                 ..............................gtvdylcnnpgakdlfy-----------------.-....---------------.---------------------------....-----.----.............---...-.-----..----..WNDRLGLSYLK...TTAG...Q...M...N...W..IEFTTPLIIKGRYKVWVCWRS.NNA....NTGLGMQ..T....W-......V.D..G.VL.LprT..FSFG..DYNYGKtltedQVRAQGWKR......YYVGA.STADHMASKLLGT....-VEILTTGRHKIRFVTTEVSPKTSASWLDMIHFI-----pet................................................
R5JUE6_9BACE/340-515                 ........vpkattvkwdltdyeelgaicekfqlanlsatylynylg-----------------.-....---------------.----------------------FDYPS....CYAYS.SSNF.............DYY...L.---AN..KNEV..AYKCVNHDCLR...FRFS...K...Y...G...W..IQMRTPMIIAGKYTVSLAHYN.---....---VAA-..-....-K......E.K..G.GK.W..A..VIID..GEYVGG.....------QVT......TTGES.TSKSSYSTVKVGE....-VEFAESVTHTVRFL------------------------sgstetsyldclifepv..................................
L0G2T2_ECHVK/373-532                 ......................qyqnsslnstytrtftqeeltcytw-----------------.-....---------------.---------------------------....-KSTP.EYRTn...........aVAY...R.NNRGA..DGIW..YADAVNHDHLR...LDLG...Q...S...G...W..IEMETPVLIKGSYEITMTYLS.---....------Y..T....ER......E.N..T.GY.L..Q..CSMD..GKRLGS.....-------QW......PVSNR.RYDRALERRMTSS....-FTFDETGSHTLRIVAIDGELL-----------------tldhirfkpv.........................................
A0A1W6E5R2_9BACT/350-466             .........dvadfpeirklpayfgkrsydfvygsvkdinwersnfn-----------------.-....---------------.---------------------------....-----.----.............LSY...I.---YT..TASN..FSVYRND-YLM...IPLGgpnR...S...V...W..VDLKTPMLVKGRYKVWVCYRF.QKQ....SGGSVNI..C....QG......S.V..D.--.-..-..----..------.....---------......-----.-------------....---------------------------------------gemlprpmaft........................................
R6DFY7_9BACE/363-574                 ...............................................FDFCDFPEVASYIASHGaD....GQLYQQKSGDNELATaLAS-------SSESYVSCYKMEM-GPS....GTISS.GWKN.............LEY...R.TANDK..AEYN..WWNLLNYDLLG...INLG...Y...N...G...T..LTMETPAILQGKYKVTLGFAY.ASS....MNFMRLA..GdvssEG......S.N..G.GS.T..S..FTFD..DDPGKS....vSKAIYASVP......EDVLN.CYTVELFG----E....-LEFADTRSHKLQLVVLDPAASTHKNFRLQLDYLLFEPI...................................................
E5C5Y2_9BACE/357-558                 ...............................................FDVCNYSIIGDWIAA-G.N....GE-EGIKFQE--SFG.TAEK-----KCDVAGLNCYEYSLNNPS....GTFSS.YFNV.............TYF...T.T---R..TNNG..WNTANNMDFLM...LNLG...N...T...G...W..ISMQTPSIIKGKYKVTLQFGY.ATS....MDFIRTQdsK....GG......S.N..G.GR.M..T..FSFD..GENSVT.....-HAPYTTIS......SNTLG.C-----YSYVIYD....ELEFSETSTHTFRLVINDPAASKNASYRIYIDYLLFEPI...................................................
A0A0L8V7H9_9BACT/363-559             ...............................................WDVCDFDDVASFVNAYG.AenelGDIYQIPQSGEHWIQ.FTTD----------AIKSYSWKE-NST....AGWYP.PLGY.............LVT...K.TNDGG..KTNT..YKAYKND-MLV...VNLG...Y...L...G...H..VTMQTPVLLQGRYKVELFYAS.AGS....LAPFVS-..-....--......-.G..G.SL.C..K..VSLD..ATENE-.....-VYVYDGAK......ASVG-.IYGMTLFN-----....EIEFDETDAHQFKVVLLDARATTHSAYRLQLDYLKFTPI...................................................
#=GC seq_cons                        ...........................................t..................................................................................h.............h.Y...p.ss.ts..ssts..asshhNtDhLh...lsLG...t...s...G...W..l-hcTPsIlKG+YKVplsatt.sts.....p..h.................s.s..s.uh.h..p..ashD..sp.hts........hhtttp......s.stt.t.ssthhs.hhhp.....lEFppTspHsl+hshh-.t..tttt.h..lchl.F......................................................
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