#=GF ID   DUF530
#=GF AC   PF04409.16
#=GF DE   Protein of unknown function (DUF530)
#=GF AU   Waterfield DI;0000-0003-2885-5126
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   COG1771
#=GF GA   27.00 27.00;
#=GF TC   75.80 66.00;
#=GF NC   20.40 19.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR007503;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Family of hypothetical archaeal proteins.
#=GF SQ   37
#=GS A0A1D3L1I3_9EURY/1-521  AC A0A1D3L1I3.1
#=GS F6BA65_METIK/120-477    AC F6BA65.1
#=GS A0A2Z4L967_9EURY/1-536  AC A0A2Z4L967.1
#=GS O26688_METTH/1-523      AC O26688.1
#=GS A0A165Z804_9EURY/1-522  AC A0A165Z804.1
#=GS A0A1D2W9J9_9EURY/1-522  AC A0A1D2W9J9.1
#=GS A0A328PAM8_9EURY/1-518  AC A0A328PAM8.1
#=GS A0A166CT68_9EURY/1-521  AC A0A166CT68.1
#=GS A0A328SAQ8_9EURY/1-171  AC A0A328SAQ8.1
#=GS D7DTU5_METV3/50-171     AC D7DTU5.1
#=GS Q6LYP0_METMP/1-122      AC Q6LYP0.1
#=GS Q5JH83_THEKO/2-261      AC Q5JH83.1
#=GS A0A328S9W8_9EURY/1-93   AC A0A328S9W8.1
#=GS A0A328RX62_9EURY/1-534  AC A0A328RX62.1
#=GS A0A1V6N2R0_METAZ/1-546  AC A0A1V6N2R0.1
#=GS U6EDN4_9EURY/1-520      AC U6EDN4.1
#=GS Y1110_METJA/1-134       AC Q58510.1
#=GS Q6LYP0_METMP/120-474    AC Q6LYP0.1
#=GS A0A2U1S833_9EURY/1-524  AC A0A2U1S833.1
#=GS A0A328SG38_9EURY/1-536  AC A0A328SG38.1
#=GS A0A328SB69_9EURY/1-123  AC A0A328SB69.1
#=GS A6UUW6_META3/2-128      AC A6UUW6.1
#=GS A0A366MEU1_9EURY/1-557  AC A0A366MEU1.1
#=GS D3E2Q0_METRM/1-524      AC D3E2Q0.1
#=GS F6BA65_METIK/1-127      AC F6BA65.1
#=GS Q8U0L0_PYRFU/3-262      AC Q8U0L0.1
#=GS Y1110_METJA/126-484     AC Q58510.1
#=GS R9SJH8_9EURY/1-518      AC R9SJH8.1
#=GS C6A3G2_THESM/3-266      AC C6A3G2.1
#=GS F0T7L5_METLA/1-521      AC F0T7L5.1
#=GS A0A315XMX3_9EURY/1-524  AC A0A315XMX3.1
#=GS A0A166D262_9EURY/1-522  AC A0A166D262.1
#=GS F0LJT7_THEBM/3-263      AC F0LJT7.1
#=GS D7DTU5_METV3/166-519    AC D7DTU5.1
#=GS E3GYM4_METFV/1-511      AC E3GYM4.1
#=GS A6UUW6_META3/123-482    AC A6UUW6.1
#=GS Q2NI37_METST/1-534      AC Q2NI37.1
A0A1D3L1I3_9EURY/1-521             ..................................................................................MNESVLIAKAERFLDNIKHNRIIAEEI........SDFETFRDTY.SYLQDNLEELQDLRDTMEIKGYKAPYRSIIRY....GGT...HS..TEMKAEDMYDVGRHTQYFRMRAAAKKNILDRVKSSIASHKIAIGQLEEYAVLTCSSCGKRFRGHEIAL....................................LK.KTCECGS..KDFTFSVNEDGVYRLNIIKYLPLSGEYMLRMADLSPMGRDAFRNIVRILKHEKRGIVKTLSLVVKV..LED..GKWVRKRVNIDAKDDMNYEREIRQKYGSNARIEFMQIHRKKPAIINDKQVQTALSIAYVKVAEHNARKIFDEVLKGLISDREK..LDTYDQAFEAAEKRAHR..IAEDAS..DVED..LREEFLNQALKSENLITEDGSMDKELQKDMETRKCLEKKLFVEMPKILILWDVIRYYLLTSYDRRSKYSGPFPNLRPSLDTNQMK...AFED...FDPFTVD...I...MRSNLKENIRYIPNIKAV.........VSRKFEIEGKMKGLHVQMNTPASGAAILHTHG.KLSIEDAADIFSV..KPADVTAEVNKFKTFGKPQ...TKKARKFLEMVK........
F6BA65_METIK/120-477               ..............................................................................ledi---------------------------........----------.--------------------------------....---...--..--------------------------------------------------------------------....................................--.-------..------------GNKKIIQHLPYDGSYKISITGLSPYLINAYKEMLNILQSQGKGVVTSITLSLIV..FKD..GKREFKRIKIEDE---NYEDYIKKHYK-DAIITSMKRNYSKNKLIDDQYVRRVLAVGYLNAYKDDIEKVIRDKLNELLTGEQKkmLETYKKIVGVEEEEDYEggIFDMRV.lDEKK..VRELETIEKLEKEGLY-RNGRPIEDLKIALDTEKEISKKVATEILTEQLSRDIFMYYLHKSPDERTR-SNLFPSIMTTPSKAHLK...WMKVsgiDVPKVLDlkfL...LEKELPKYNIPLKDLGGL.........VLYLVYDWDKVEEFKFKKKNV-----EDLLKK.IAPIESIKDILKD..KDV----DISKIEKYSKVK...KEKTKKFLEAL-g.......
A0A2Z4L967_9EURY/1-536             .................................................................................m--SEVLVKHAETFLKDIQKKPVIAEGI........EDFDSYIEIY.SYLYDNLTKLQNLRNKMEIRGFTSPFAAIKRFnkgaNTG...NA..PEIIPDDVHDQSRHAQYFRIKASNKKNILDQVKSAIASHKIAIGHLEEYGTFKCNECKQKYTKNHIQDlltyd..........................ddydvTG.FMCECGN..SDFTFEETVSGICRLELIKYLPLGGEYLLKRSQLTRYSLEAYRDITKIMKQEKRGRVKSVTVIAKV..KDEktGKWVSKKANIDYADEHNYELELRKRYGSNARIELLQFNHKKPSLINDKYVQNALAIAYLQYTENIVNNQIDDIIPLHIRNMDK..VNKYNRILEQARSDASR..LAREAD..ERIE..LEEELKYLKLKKENLINSNHELDRGLKEDLAREVKIRKHYYIDTTKTIILWDLFKYYMTTSENRRNNYSGPFPNLRPTLDSNQIK...VFDR..vFSKDIIQ...L...LHDN-DENIAIIENMKEC.........IQYKQDLENKRKNLHLKSNQAACGAVVLNKKS.NISLNKAADLLYV..DYEEASKEKVELNRIEKPS...TKKAKKFLELIN........
O26688_METTH/1-523                 ..................................................................................MNESGLIARSERFLESIKDRKVSLDDL........KSVEGFIDLY.TYLRGNLEELQDLKEAMELRGFKYPFRSISGY....SSQ...YS..PEI-AEDVHDIKRHAQYFRMKASTKKNLLDRVNSAISSHRIALGNLEEYALLQCPDCSRSLRLSEVEYqd................................ilDG.VMCPCGS..GRMEIEFSGSAICRPEIIPHLPLSGDYMVKMSELSLWARKAFKKIMRLFKNEKKGAVRSATLVIKV..LED..GRWIRRRITIDSDDN-DYERMLRQRYGPNVRIELIQFHRKKSSIINDRYTRTALALGYAGLSHDIIMDIKERVYSEKLRDYDA..VKRYRRILFEARTYSPD..LRLSED..ELQE..VRVQKMHDLLHEAGLGDSGGRLNRELREDLEVMEEVKRELFRDVPVNLVLWDVALYYLGTSLDRRSKHAGPFPNLRPVLDRSQVR...TFDE...LSRDAVD...L...LNTCWEGGMVYIDKLGDV.........LLKKFEIEDKMKGLHMKPNPLAFGAAVLHMEG.EADIETCAEIFHV..RVEEVVEEKRNIENLGKPS...TDRAKMFLNLIK........
A0A165Z804_9EURY/1-522             ..................................................................................MEETSLIKKAESYLNKIANKRIDLSNV........SKLDNFINIY.QSFTQSLDVLVEMKSDMEMRGYMSPYSSLTKY....GAP...MS..NEVHYDELAEISRHGQSVRRCATAKKIILDRIKSAIDSHKIAIAHLEEYALINCNSCYNEYKLSEFLI...................................lKE.KKCSCNC..SNFSISPNQNTVYRLDIIPYLPLSGNYMVLRAQLSHWGRKAYTKIVNSLSKKKKAVVKTVSLAIKY..NKD..GRWLTKNLNLDSDYVDLYEEKIKELYGKDAKILRLNFNHSNPSIINDKHTITALALAYSQLSQEIVKKNSSSILKENISDYNS..LKSYDNIIFSIKNEQPR..FIVDEN..SLEE..WRDLKIKDSLKDKGLMDKSFKLNPKLKKDLYSREQLENRIFSEIGNVLILWDIFKYYLTTSNDRRKRYKGLFPYLRGDIDRTQRE...VFAN...YNPKTID...L...LVKYGCEKILKIKDMDLI.........LFEKFKLEKKIKGLNMNFNYLFLGAALISLNS.NLDWEIIEENFNI..NSEKIKKGIEDINMINQPR...SDKSKKFLGLV-s.......
A0A1D2W9J9_9EURY/1-522             ..................................................................................MNESVLIARAEKFLDKIKRQRIQVEEL........RDFESFITVY.HYLKENLDELYELRDTMEIKGYKAPYRSLIRS....SRS...SI..TELKAEEIHDVSRQTQYFRMKAAAKKNILDRVKSSIASHKIVIGHLEELATITCSACKKKFKRHEIEF...................................vES.GTCSCGA..KDLILEKNDQGVYRLGTLKYLPLSGEYMVRMSDLSPMGREAFRSIVRVLKHEKRGIVKTVSLVVKV..LED..GRWIRKRVNMDMDDEMNYEREIRKKYGRNARIEFLQFHRKKPAIINDKQVQTALSIAYVKFAKEIVDEIMDNVMDKFLKNRNN..VEIYDNALKAASDVAGS..ITSDIE..DEED..IKNEKLNEILKENNLMDDNDIINRQLERDLQTRNKIKRKLFVEVPRVFILWDIVRYYLTTSYDRRNKYSGPFPNLRPNLDTNQLK...AFVD...FDKQVVG...I...LKEYTDEKIEYMEDMKEV.........IAKKFEIENKIKGLHVKSNPPAVGAAILNITG.KLSIEVASDIFSV..DPENVKAEKEKIETFGKPT...SKRAQKFLEMIK........
A0A328PAM8_9EURY/1-518             ..................................................................................MEEPALIAKSEKFLESIKIRKINPDDL........IDPKGFIETY.TYLRSNLRKLQKIKKRMELKGFKTPYRSMAIY....GPP...LK..GELKAEDLHDIRRQTQYFRMKASLKKNILDRVNSAIASHRIALGHLEEHGALTCEMCRRTFRLGELSE...................................nEL.RECECGS..-TLQVKFEDGNIKRLEIIPYLPLSGDYMVKISQLTPWARESFKEIIRLLKNEKSGTITSATMIIKV..QES..GRWVRKRMTIEDIDHIDYEKKLKQQYGPHARIEFIQFHRRKSTIINDRHVRTALALGYSGFIQDFLAKIEDEILKKRLKKPHI..VKRYDEIREEAEEYSPT..FVREGK..ELEE..IRKRRLEDLLIQEGLADENGNLKPDLKSDLELREKIM-NIFSRTPITLILWDIACYYLTTSYDRRSKYAGPFPGLGPVLDRKQVK...TFDK...MDKEAVK...L...LKEY-GEKIFYIKNLQKL.........LLKKFEIEEKIKGLHMKINPRAFGAALINLES.GIDEKTCANIFSV..TLEELKRERENIKALRKP-...TDKARLFMEMIK........
A0A166CT68_9EURY/1-521             ..................................................................................MDESSLISKTEKYLVKIQNEKIDLESI........SKLEVFKSVY.SRFTYRLDKLQNMKGSMDAKGYTAPYRSLSKY....GSN...VS..GDVAFEELNEVNRHSQYFRMKATAKKNILDRVKSAIDAHKIAIGHLDEYAIFKCKSCSKTYRPSKFFE....................................IN.ERCSCNC..ENFEFVINHTGVYHLEIIPYLPLSGNYMVLMLELSSWGRESFKKVLNILKQERKGVVKTVSVVIKF..MEN..ERWIRKRVALESEHVDNYEEEIRKRYGNNVRIEFLQFHRTKPTIINDKHARTALALGYVKYSEDIINQNKAAILKERIKDVSK..LNTYDQIITEVKLEKPN..FIEGEE..SLKE..WQELESENRLKKAGFIDKNGKLDQELLRNIGKKRAIEKNIFSDLASTLILWDIFKYYLTTSNDRRKRHGGPFPYLRGDLDRQQRK...IFEN...LNKNVVE...I...LKTMANQKILEVKNMDLL.........LHKKFNLEKKIKNSNIMINYTALGAAIISSNC.NIPISISADTFNV..SKDSVKKELKNIETINTPK...TNKSKKFLELIK........
A0A328SAQ8_9EURY/1-171             .................................................................................m--SELLVTQSERFLKSIQKKPLIAESI........EDFESFIEIY.VYLRDNLVKLQNLRNKMEIKGFTSPFSTLKRY....GRTpnnNT..IDVIPDDVHDQSRHAQYFRIKATNKKNILDQVKSAIASHKIAVGHLEEFADITCSACGEVYRKNEIDNllvyd..........................edfnvTG.HRCECGC..TDLNLX------------------------------------------------------------..---..-----------------------------------------------------------------------------------..-----------------..------..----..-------------------------------------------------------------------------------------...----...-------...-...------------------.........--------------------------------.-------------..-------------------...------------xt......
D7DTU5_METV3/50-171                .......................................................eninfedentlleynkpnkfknfdkyg---------------------------........-VYSSKTQLL.NDLEKNLNILESYREKMELKGFDTPYIGVGKL....NGG...--..---EEDDIYDILNYSSYLRRVVDEKKGTLERVKYAIVSHKIAIGNLQD--------------------....................................--.-------..------------------------------------------------------------------..---..-----------------------------------------------------------------------------------..-----------------..------..----..-------------------------------------------------------------------------------------...----...-------...-...------------------.........--------------------------------.-------------..-------------------...------------dgnldl..
Q6LYP0_METMP/1-122                 ..................................................................................MDSSVLIKECNDFLDCLSNFGKKLKDFd......sKKEDSVNAVS.ETLENNLKILENFREKMELQGFDTPYIGVGRLk..gG--...--..---EDDDIYEIINYSSYLRRMVDEKKGALERVKYAIVSHKIAIGNIQE--------------------....................................--.-------..------------------------------------------------------------------..---..-----------------------------------------------------------------------------------..-----------------..------..----..-------------------------------------------------------------------------------------...----...-------...-...------------------.........--------------------------------.-------------..-------------------...------------dmg.....
Q5JH83_THEKO/2-261                 .............................................................................tttee-----LVAQVNKILDDI---GIDLGEL.......fQDFDPV-RLA.LTLNRNLSLLEELEEELERR--------VGEG....---...-G..PSVPMGDRKNRDPHLQWLYRKRHYRTLALERLRSAITAHKIALAILDA--NYTFKRGSSEIKATEIK-....................................--.------D..EKVKATRKPYSIGRVEILPYLAYSGDVLKLLARESLSVRDAFKEIKGRLREQGMVKTRSIRLEVEY..FEN..NRLKKAHVSLPAD--ADIEAELRKQFGRRFRWRVLSLVKTRGVLINNHYTVDNLALAYASFN---------------------..-----------------..------..----..-------------------------------------------------------------------------------------...----...-------...-...------------------.........--------------------------------.-------------..-------------------...------------pekgae..
A0A328S9W8_9EURY/1-93              .................................................................................m---------------------------........----------.--------------------------------....---...--..--------------------------------------------------------------------....................................--.-------..------------------------------------------------------------------..---..-----------------------------------------------------------------------------------..-----------------..------..----..-------------------------------------------------------------------------------------...----...-------...-...--KENDENIEIVSNMKDA.........IQYNMDLESKRKKLHLKSDHALCGAVVLNTKT.NLSLNRASELLYV..DYDDAVKEKANLSKIEKPS...TSKAKKFLEIIN........
A0A328RX62_9EURY/1-534             .................................................................................m--SEILVTQSEKYLKRIQSKPVIAESI........EDFDSFIEIF.TYLKKNLEQLQNLRNKMEVRGFTSPYSALKRF....GKN...TSgpQEIIPDDVHDQSRHAQYFRIKASNKKNILDQVKSAIASHKIAIGHLEEYATVTCKKCKQTYKKNNIENilhfd..........................ddfeiES.ISCECGS..TDFEIHSNNSGICRLELIKYLPLGGEYLLKRSQLTKYSLEAYRSIIKVMKQEKRGLVKSVTVIAKV..KDEktDKWVSKKAKIDYADESNYELELRKRYGSNVRIELLQFNHKKPSLINDKYVQNALAIAYLQYSENIVNQDIDEIIPLHIKNMDK..INQYKKLVEEARNDASR..LAREAE..ERLE..LEEELKYIKLKKNNLMNKERVLDRELREDIEKKVEIKKHFYMETPKTLLLWDIFKYYLTTTESRRNNYSGPFPNLRPNLDSNQVK...VFEY..vFPKDIVN...L...LLDH-DENIASLNNMKET.........IHYKTELETKIKNLHLKPNQEAIGAVAIHNKC.DVSLNKAADLLHV..THDEAMTEKNNLKIIEKPT...TKKAKRFLELIN........
A0A1V6N2R0_METAZ/1-546             ..................................................................................MDESILISKAEKYLNEVQNEKISLEKI........SKLESFKSVY.SILTKRLSNLQEMREDMDLKGYTAPYRSLNKY....GST...SS..GDIAFEEMSEVNRHGQYFRMKATAKKNVLDRVKSAIDAHKIAIGHLEEFGIFKCESCSKSYKPSAFIElskkksannrni...........enienkeniskleEK.EECSCGC..NDFKFEINKTGVYRLEIIPYLPLSGNYMVLMSEMTSWGRESFKKVLSILKQERKGVVKTVSAVIKF..KEN..DRWIRKRVSLDSEYVNSYEEEIRKEYGKNVRIEFLQFHRTKPTIINDKHARTALAIGYAKYAENIVQNNKESILKDKISNIYK..LAKYDEIVRDVKLQRPK..FVVGED..SLEE..WRRFETENRLKTVGLMSKRENLDPQLKQDIHKRKNVEKRVFSEVASTLILWDIFKYYLTTSQDRRKRYGGPFPYLRSDIDRKQRR...IFEN...INKEVVN...I...LKNNENEKIIELNNMDLL.........LNKKFNLEKKIKGSNIKIDYVSLGAAIISSNC.NIPVSLSSKTFNV..TEKSVENGIKNIDTFKKPK...SNKSKKFLEMIK........
U6EDN4_9EURY/1-520                 ..................................................................................MNESVLIGKSERFLDQIKRKEISLTDI........VSPEKFLSLY.TYLQNNLDSLHDMREIMEIKGYTAPYRSINKY....GRP...LT..GETKAEDMYDISRHTQYFRMNAAAKKNILDRVKSAISSHKIAVGHLEEFATLECSSCHKKYRGHEIAL...................................lTP.GKCECGQ..NDLKLHVNQEGVYRLGIIPFLPLSGDYMVKLSELSPRSREAFRRIVRILKQEKRGIVKTVSLIIKV..MED..NRWVRKRVTIDAQDDANYEKEIRSQYGPNARIEMMQFHRKKPSIINDKHMQTALSLGYVKYAENRILQFLPDLLEKTLHNKDK..VEEYQEAVEISKIKANK..Y-DTGD..DPES..LKNFYLKMELKDRGLLDKDGKPEKTLQNDLKEKNLLEKSLFHEMPRIYILWDILRYYLTTSYDRRNKYSGPFPYLRPGLDTNQIK...AFQD...FEVEVVK...I...MQEYLSEDITYIPHMGRV.........LSKKFSVEKKMKGLHLQMG-PALGAALLSSEA.NIPVEKSAQLFSI..KVEDVSKGKETLSTLQRPT...SSRAKQFMAMMK........
Y1110_METJA/1-134                  ..............................................................................mest---SNLIKNANEFLDSLNEINDKLKEVvgkiknktIDKTKLSDII.LTLEKNLEILQDLKSKMEFLEFDSPYKNVGKL....K--...--..GGYDSEGLQEIASYSTYLRRIASEKKGILERVRHALVAHKIALAHLTE--------------------....................................--.-------..------------------------------------------------------------------..---..-----------------------------------------------------------------------------------..-----------------..------..----..-------------------------------------------------------------------------------------...----...-------...-...------------------.........--------------------------------.-------------..-------------------...------------digninl.
Q6LYP0_METMP/120-474               ..............................................................................dmgn---------------------------........----------.--------------------------------....---...--..--------------------------------------------------------------------....................................--.-------..--------------KKILAHLSYDGSYKELLSKIPPFFIKSYKRILSVFETEGKGILSSITLSLVI..LEN..GKRKFKRIKIEEE---DYEGYIKKTFG-DAIITSIKKNYSKNKLLNDQYVKKILSLAYLSACSDEIIEKIDETLKETLSDEERciVKKYRMICSDFKSSDCE..-SGVIDvrAMEEikLRKMNLKNDLEDRGLY-KNGKPLKKLKESLEMEDEILENISLEVPLKILSKDLLTYYLKKSADERTR-SNQFPSILVTPSPAHLNw.lAVEN..iAPKKILDlkfL...LEKELPKYEIPIKNLGGVslyllydwnVVESFEFEK-----------------------.-TEIEEILKLMAAinDVKELLKDKIDIKKFEKYSkikKDKTKNFLNAL-g.......
A0A2U1S833_9EURY/1-524             ..................................................................................MEESSLISKSEKFLNEISKESIDVSQL........DDFEEFKSLY.FKLDDRLSTLHTLRNQMDLQGYTTPFRSLSKY....GNT...TS..DVVSLEEVSENSRHNQFFRMKANAKKNILDRVKSAIDSHQIAIGNLEQYGYVKCESCYKKYRMNEYKE....................................NE.CKCSCGS..EQFSFKINKDNSYRLEIIPFLPLSGNYRVHMTQFSNWGRDSFKKVLNLLKQERKGVVKSISLVIKF..KDE.nNRWIRKNVTIDSDHVDNYEEEVRKTYGKNVRIEVLRFHRTKPAIIDDRHARTALAIGYVKYSEKLVNEMKDSIFKKRISDFKR..LNKYNDLKHEIATKKPT..FIDEHDtaSLES..WRKTEFEETCKKLKFMDKFGNLNRSLKRDLKIKENIEKSIFTNIAPTLIIWDIFRYYLTTSHNNRKITSGPFPYIRVELDRQQRK...IFQT...TYKKVIE...T...LNEETNLKLIPIPEMDLV.........LYEKFKLEKLIKNTKMKINYPALGAGLIHKTT.EIPIENIGNALNI..NNSKIKKEIKNIETIRKPK...TEKSKKFLELIK........
A0A328SG38_9EURY/1-536             .................................................................................m--SEALVTQSEKFLKKIQHKPVIAEGI........ENIESFLDIY.TYLKTNLIQLQNLRNKMEIRGFTSPYGALKRYgkigGNN...NN..PEIIPDDAHDQSRHAQYFRIKASNKKNILDQVKSAIASHKIAIGHLEEYATITCKKCGQKYKKNTIENilefd..........................ddykiTN.IHCDCSS..EDFEFETNNSGICRLELIKYLPLGGEYLLKRSQLTKYSIEAYRTIIKVMKQEKRGLVKSVTVIAKV..KDEktGKWISKKANIDYADESNYELELRKRYGSNVRIELLQFNHKKPSLINDKYVQNALAIAYLQYSENIVNQNIDEIIPLHIRNMEK..INTYRKLIEEARCDASK..LAREAE..ERIE..LEEELKYIKLKKNNLMNKDRVLDRELREDIEKKISIKKHFYMETPKTLLLWDIFKYYLTTTESRRNNYSGPFPNLRPNLDSNQVK...VFEY..vFPKDVVN...L...LKDH-DENIDSLNNMKES.........IQYKSELENKIKNLHLKSNQEAIGAIAINNKC.DLSLNKSAQLLHV..DPKEAVKEKNAINKIEKPT...TKKAKKFLELIN........
A0A328SB69_9EURY/1-123             .................................................................................m---------------------------........----------.--------------------------------....---...--..--------------------------------------------------------------------....................................--.-------..------------------------------------------------------------------..---..--------------------ELRKRYGSKARIELLQFHHKKPSLINDKYVQNALAISYLQYCENIVNKAIDDIIPKHIHNMDK..INLYKRLLDESRSDASR..LARGAD..ERIE..LEEELKYIKLKKANLINSERQLNRELX----------------------------------------------------------...----...-------...-...------------------.........--------------------------------.-------------..-------------------...------------xtkql...
A6UUW6_META3/2-128                 .................................................................................e-DSSSLIKRCNEYLTELQQFREYLLELran..ktnIDKSTYDEIT.NKLKENLEILEDLKEKMEICGFDTPYMGVGTL....---...--..KGCDDSDIYEIKNYSSHLRRMVDEKKGALERVRYAIISHKMAIGNLSD--------------------....................................--.-------..------------------------------------------------------------------..---..-----------------------------------------------------------------------------------..-----------------..------..----..-------------------------------------------------------------------------------------...----...-------...-...------------------.........--------------------------------.-------------..-------------------...------------dagn....
A0A366MEU1_9EURY/1-557             ..................................................................................MDESILISNTEKFLNEIQKEHINLESI........YKFKVFKSAY.CKLTDRLNKLQEMKEDMDSKGYTAPYRSLNKY....GSN...VP..GDIAFEELNEVNRHGQYFRMKATAKKNILNRVKSANDAHKIAIGHLEEYGVFKCESCSKSYKPSTYMGlskqeqlkdknhteknddntsnkqekfkydqnysenSK.EECSCGT..NEFKFEINKTGVYRLEIIPYLPLSGNYMVLMSEMTSWGREALKKILNLLKQERKGVVKTVSAVIRF..KEN..KRWIKKRVTLDSEYVDCYEEEIRKQYGKNVRIEFLQFHRTKPTIINDKHARMALAIGYSKYAENIVQNNKEAILKDKTSNIYK..LAKYDEIVRDVKLQRPK..FIVEED..SLEE..WQRFEVENRLKTVGLMSKRENLDPQLLQDMKKRKTVEKNLFSEVGPTLIIWDIFKYYLTTSYDRRKRYGGPFPYLRSDIDRKQRK...IFEN...MNKEVVK...I...LKINESEKIIELQNMDLL.........LNKKFNLERKIKGSHIQIDYVAMGAAIISSNC.NISVSLSSKAFNV..TEKSVEKEIKNINTFKNPK...TNKSKKFLEMIK........
D3E2Q0_METRM/1-524                 ..................................................................................MDESLMITESEKFLNQIEREKLDLTNLks....dfSDLESYLEVY.ELLKSNFDKLQDMKESMDERGYTAPFRSLNRY....GSR...VS..EDVDYEELGELNRHNTIFRNNASAKKNSFDRVKYAIAAHRIALGNLEEYAKIRCKDCQKSYKVSTFLE....................................NS.KTCKCGS..TDFELKVNHSGIHRLEIIPYLPLSGNYMVLLSSLSGWGRDSFRRILNILQQKRKGVVKTVTPIIRI..KEN..GRTITKRVNLDSEFADCYEEELRRIYGKGVRIERLEFHSTKPTIVNDKYTRTNLALAYVKHAEDIVSRHEEEIFEENIKDLNN..LKTYDELIYSVNLEKPE..YMDEDD..-LDS..WREQKIQDNLLELGLMDKYGHLDKQLKKDLKERERIKSKIFADIAPTLILWDISKYYLCTSYDRRKRYGSPFPFIRNDLDRQQRK...VFAN...PHANVVG...L...LREKEKKHMIAIDEMDLL.........LYKKFKLEKRIKNTNFKLNYAALGPAIVFANS.DYNIKEVSRAYKV..GEKSVKREIMNIKSFRKPN...SKKSREFLGKIK........
F6BA65_METIK/1-127                 ..................................................................................MESSELIRESNEFLDNLKRLKFEIEELl.....kkKLEDSVIEEYaKKLEENLKILEELKEKMELLGFDTPYTNVGKL....---...--..KGFDSDELYEIMNYTSYLRRIANEKKGVLERIRHSVVSHKIALGHLLE--------------------....................................--.-------..------------------------------------------------------------------..---..-----------------------------------------------------------------------------------..-----------------..------..----..-------------------------------------------------------------------------------------...----...-------...-...------------------.........--------------------------------.-------------..-------------------...------------dignkk..
Q8U0L0_PYRFU/3-262                 ..............................................................................ttee-----LIARINKILDDIA---IDTPGL.......fEDFDV-PKLI.FTFKSRLETLKELEEELERR--------VGEL....GPT...--..--PIIKDKKSKDPHLSWVYRKRHYRVLTLERLKSAITAHKIALSILEANYILKINRSEISLEALKK-E....................................NL.SKIKAIE..KDIK-------LGRVEILPYLAYSGDVLRILGQRGIEVREHFKFIKSKLREEGVVRKEKFRIEVEY..LEN..GRLKKEKVELPVD--SDIEGELRKRYGRRFRWRVLSYVKTMGVLINNHYTVDNLALAYGT-----------------------..-----------------..------..----..-------------------------------------------------------------------------------------...----...-------...-...------------------.........--------------------------------.-------------..-------------------...------------lnpreg..
Y1110_METJA/126-484                ............................................................................tedign---------------------------........----------.--------------------------------....---...--..--------------------------------------------------------------------....................................--.-------..--------------INLPPNLPLDGSYKKIMFEFPPYLVTTYKEFLDILEPKGRGILTSYTISLIV..IDK..GKREFKRIKVEDK---NYEKYIKEKFG-NAIITSIKRNFSKNKIIDDQYVRRVLAIGYLNTYKDEIEKAINEKIDKLLNEEEKkyLNRYLELCLLFREEADI..SGGILDvrCMEErkLKELELKEILEKEGLY-RDGEPIEPLKKAIKIKNELSKKISKDILIKRFSEDVFKFYLYKTPDERAR-SNLFPSIMITPQRGFLSw.mSVDG..iNCVDVLD...LkfkLEEELPKYQIPLKNIGGV.........ALYLIHDWDAVERFNFKKKDI--E---DLLKK.IALIEPIKEILKD..KNVDV----SKLEKFGKVK...KEKTKKFLDLL-s.......
R9SJH8_9EURY/1-518                 ..................................................................................MDSNRLITKAEEYLKKISEEQIETSRL........SDFEYFKKTY.DNLNNHLNILQEFKETMDTQGYTSPYRSLSKY....GIS...TV..ADVTAEEASETHRHNQYFRLKASAKKNILDRVKSAIDAHKIALGNLEEYGLIHCKNCNKTYRIDNYK-....................................--.AECDCGK..TEYSFSINKNGNHRVDIIPYLPLAGDYMVKMSELTKWGRESFKKVINMLKQERKGSVKTVSLIIRY..RED..KKLIRKRVSLGSDYVNSYEEEIRKRYGKNVRIEALQFHRTKPAIIDDKNTRTALAIGYVKLAELIANRHKDEILKENIKDIDK..LNKYDEIVINAKTANPG..FLDETD..SIEA..WREEKIDADLKDANLKYGNGDLNRTLEIDLRNRQLLEKSVFINIAPSLILWDIFKYYLTSSNDKRKRQSGPFPYIRSEIDRQQRK...IFQI...TFTKAIE...L...LNKKEHENILPVKEMDLI.........LHKKFKLEEELKNSNLKVNYQALGAAMIYNEG.TIPIEECAKSFNL..DVKDVKKESKNIENIAKPK...NDKSKKFLELIK........
C6A3G2_THESM/3-266                 tteeliaqinrglddirininrlfenfdprylafnlnrnlmilknmedelsrrvgeahiyvgslgkkerdphirriflrnhy---------------------------........----------.--------------------------------....---...--..------------------------RMLTLERLRIAITAHKIALATIDSHYTF--YKGKKGVDIKNIT-....................................--.NKRDLEK..--LKVAEKSIKLGRLEVLPHLAYSGDVLKILSQQDNKVRDTFKEIKSKLKEKGQIRKKGIRIEVEY..WQE..GRLKKERLDFPVE--ADIDSELRKRFGQKYRWRVLSYVKTKGVLITSHYTVDNIALAYAST----------------------..-----------------..------..----..-------------------------------------------------------------------------------------...----...-------...-...------------------.........--------------------------------.-------------..-------------------...------------ypkkgvka
F0T7L5_METLA/1-521                 ..................................................................................MNESVLIAKTEKFLDGIRRNPLKIDNI........NNFKDFINIY.HQLKNTLDDLLELRDTMEIKGYKTPYKSLMKY....GRT...SK..SEMKVDDIYDVNKHTQYFRMNAAAKKNILDRVKSAIASHKIAIGHLEEYAVFSCGNCGENINGHELET...................................lVN.GNCKCGS..DQIQMKVNDQGIYRLEIINYLPLSGDYMVKMSELSPLGRDAFRRIVRSLKQEKRGIVKTVSMVIKV..FQG..DRWVRKRVNIDADDQMNYEREIRNKYGSDARIEFMQFHRKKPSLINDKHVQTALSIAYVRLAENKAGQVFGSVLEANITNMNK..LERYDHVLKESRELARK..LVEDPD..DIEQ..IKKEILEDRLFKEGLE-ENGKLDKELRKDITVREKLRSEIYLEVPRILILWDILRWYITSSFDRRNKYVGPFPNIRPSLDTNQLR...AFED...FNPDVVE...I...LKGYMHEKIEYVSNMKNV.........LMKKFEIENKMKGLHVKTNPNAAGAALLNTEG.KLPLEAAARVFNT..DPKDVEAEITKFKTFGKPQ...TKKAKKFLDLIK........
A0A315XMX3_9EURY/1-524             ..................................................................................MPESVLVSKVESYLIEISNDSISLDDI........DDFDNFKSLY.FKLDDRLDKLQRFKDDMDAQGYTTPFTSINKY....GTK...SV..AEVAIEEKGESSRHNQIFRMKANAKKNILDRVKSAIDSHKIALGNLEQFGYVKCNSCYKKYSMSEYKQ....................................MD.AKCSCGS..QGFTFKINKEATHRIEIIPYLPLSGNYMVLRNELSSYGRESLKQVFNILKQERKGVVKTISMRIRF..RDK.nKRLIRRNISLGSEYVNNYDEEVRRRYGREVRIESLRFNRTKPAIIDDNHARMALAIGYVKYGEEIIESIKDEILKRRLTDFKR..INKYDEITNTYKNASPE..FIDQNDidEIED..WRKAQIEDSFRKLGYIDKFGNLTRSLKRDLKIRENIYRNTLKNIASALIIWDIFKYYMTTSNNSRKHDIGPFPYIRIELDREQRK...VFQA...SYTNVIE...T...LNSYTDIKIIPIPEMDLL.........LYEKFKFEKEIRSINIKFNHVALGAALINLNS.DIELSKISNAFNI..NESRVKKEIEHIDTIKNPK...SDKLKRFNELIK........
A0A166D262_9EURY/1-522             ..................................................................................MDESVLIGDAEKYLKKIGNEPLDLNGI........SDLDIFKSLY.LKLSNRLDVLQSMKENMDAKGYTAPYRALSRY....GMG...NS..SDVSFEEVSEVNKYGQYFRMKASAKKNILNRVKSAIDAHKIAIGNLDEYGLITCNTCSKSYRPSSLES....................................NGlDKCICGS..SDLYLKLKKHGICRLEILSYLPLSGNYMVLMSKLSRWGRESFKKILKNLKQEKKGSVKTVSLIIKI..REN..NRWISKRVNLDSEYVNSYEEKIREDYG-NVRIKHIQFHRTKPTIINDRNARTALALAYAMYSERLIKEHLDEILSIKLRDYDN..LKKYDNIIYKIGLEKPN..FLSEKD..SLDE..WRKSKIIESLQKEDLMDKNEKLTIKLAQDKKTRKILEDKVFSNLGLTLILWDIFKYYLTKSNDRRKRHSGPFPYLRGDIDRQQRQ...IFTH...LNKQAIN...I...LKTYACEKIIEINEMDLI.........LYEKFKLEKQMKGLNMKINHVALGAALLLNNSnDLDISTLAYAFDL..SEKEIKTESKNLTTVSKPR...TNKSKQFLKMIK........
F0LJT7_THEBM/3-263                 ............................tteelvaqvnkilddigidmmglfenldipvlvfylnrnleilrefeeelsrrv---------------------------........----------.--------------------------------....GE-...TV..PSVRGIDKKEKDPHIRWLYKKKHNRILALERLRSAIVAHKMALALISA---------NYSFYLGNREI....................................DP.KTIRKHEeiKKIKAVKKPVALGRIDVLPHLAYSGDVLRLLGQESVEVREAFKLIKSKLRE--KGVVRKKSFRIEVeyWDK..GRLRKTRLDIPTD--ADIESELRKRFGKRFRWRVLSYVKTKGVLINNHYTVDNLALAYAAF----------------------..-----------------..------..----..-------------------------------------------------------------------------------------...----...-------...-...------------------.........--------------------------------.-------------..-------------------...------------dpekg...
D7DTU5_METV3/166-519               ...............................................................................dgn---------------------------........----------.--------------------------------....---...--..--------------------------------------------------------------------....................................--.-------..--------------LDLICNLPYNGSYKESLLQLPHYVVKTYKKFLTILNSEGKSSLSSTTLAIVV..KEN..GRRRFKRIKVEEE---DYEKYIRDNYG-DAIITSIKKNYTKSKLLNDQYVKKILALAYLHTYQSLIGDKILENVSKMLKMNELslIAQYKQICQNYERADCE..-GGIIDvrQINElkFKKLQLVSKLEDCGLY-KEGKPLKCLEKSLEVENAIFEDACLNVPLSHLSNDLLRYYLNNTADERTR-SNLFPSILVAPSKSQLAw.lRLKN...DYKKVLNyklN...LEKEFPKYDLPIKLTGGIl......lyLAYDWDVVESYGYSKPEIE-S-------ALKI.ICNIEEITKKLDC..EPFDIAK----LQEYNKIK...KKKTKKFLNAL-g.......
E3GYM4_METFV/1-511                 ..................................................................................MNEEGLISRTERLLSEIKKSSIKVDDL........RSYDKAFKIY.RKLKSTLNKLEKIKKTMELKGYRSPYRSIAKY....-ST...YI..EEPIHEEPHEMARHARYFRIKASIRKNILDRVNSAIASHKIAISNLEEYIELKCVRCGKRFKIYE---....................................--.-KCECNR.eDEYKVVPNEKGIHRIEIIPYLPLSGDYMVKISKLSNWAREAFKKIVRTLRHEKRGTIKSTSLVIRV..FDG..KRWLRKKIVINGSFE-ECENKLRKKYGSNLRIEFMQFHRRKARIIDDRYIRNALALGYTCFCENKIEKLKNEIFNSEMKNPEY..FEEYLRIIKDVERSL--..LSLDPE..IREE..IKEEEIKKVLKEKGFLNENEELIKEIREDLKIKKEIE-EVFVNVPITLLLWDIANYYLCTSYDRRTKHSGPFPGLRPVLDRHQAK...IFNE...FNKKAVK...I...IKKYFMEKIEYIPNLNEI.........ILENFKIERKMKGLRLKTDPFAFGAAIVNLKS.DIDIEKCSKLFST..TPKNIKREKRNIKIITKPS...SDKAKRFLEIVR........
A6UUW6_META3/123-482               ............................................................................sddagn---------------------------........----------.--------------------------------....---...--..--------------------------------------------------------------------....................................--.-------..--------------KNIIFFLPYGGAYKELLMQLPSIFIKSYKKILNIFELNHKGVLSSITMSIVV..IEN..GKRKFKRIKIEDE---DYDAYIEKHYG-DALITSLKKNYSKNKLITDSYVKKTIVLAYLLTYADDIEKEINKRLNNTLSKHQRdmIVKYLEITSNYDCEYID..-GGVIDfrRMDEirLKKQELNEELEKCGLF-KDGKIIDELQTALNIEKNIYDEVCYEIPIKYLSNDLFKYYLYNTPDERSR-SNMFPSILLTPAMSQLTwanMGDN..iNPKSVLDlkfL...LERELPNYKISLKNVGGValylihdwdAVKKYGYNKKDIESILK---------------.--DIAPLSDLM--..--SNLKEKNIDIEKIEKYNtikKKRTKKFLNA--lsk.....
Q2NI37_METST/1-534                 .................................................................................m--SDILVTQSEKFLKTIQSKPVIAESI........EDFDSFIKIY.SYLNSNLKQLQNIRNKMEIRGFTSPYSALKRYs.kgGNS...SN..PEIIPDDVHDQSRHAQYFRIKASNKKNILDQVKSAIASHKIAIGHLEEYVELECKKCGQKYKKKTLEDilvy...........................denevES.CKCECGS..SEFKFDSDMSGICRLELIKYLPLGGEYLLKRSQLTNYSLEAYRKIIKIMKQEKRGRVKSITVIAKI..KDEntGKWVSRKMNIDYADESNYELELRKRYGPNVRIELLQFHHKKPSLINDKYVQNALAIAYLHYSENIVSKKIDEIIPKHIHNMKK..IDTYNSVLNEARKDAGR..LAREAE..ERIE..LEEELTYVKLRKVNLITKDHKLDRELKEDLNKESEIKKHYYIETPFILILWDIFKYYLTTSENRRNNYSGPFPNLRPTLDSNQIK...VFEN..iFPKDVIE...L...LQDS-GENIDTIPNMKET.........IQYKLDLETKRKKLHLKSNHAAYGAIALNSKS.NISLNKAADLLYV..DKDEAAKEKAALQKIEKPS...TNKAKKFLEIIN........
#=GC seq_cons                      ....................................................................................pp.LltpspcaLpplpp..l.hppl.........phc.hhplh..hLpppLp.Lpph+ppM-hpGapsPatult+h....s..........th..--h.-.ppaspahRhpAstKKshL-RV+SAIsuHKIAlGpL--.h.hph.ts.pphp.tph...........................................h.ttp..tphph..p..t.hRlcll.aLPhuGsYhhhhspho.hshcua+plhphhcpct+Ghlcohoh.lch..h-p..s+hhp++lplp.p...sYEtclRcpYG.ssRIchlpap+pKsslIsD+aspssLAluYhph.pp.ltp.htphh...lpp.pt..ltpYpplh.t.p..t.p...h...c..ph.p..hcc..h...Lpp.shh.pttp...pLtpsht.c..l.pphh.phs..hl..DlhpYYlhpo.scRpp.ss.FP.lh...sptphp...hht.......phlp...h...lpp...p....l.pht.h.........l..phphppphct.php.p...........pt..hslp..tphh.h..p.tph.tt..plpthtpsp...pp+s+pFLphl.........
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