#=GF ID   DUF5373
#=GF AC   PF17343.6
#=GF DE   Family of unknown function (DUF5373)
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   PRODOM:PD035609
#=GF GA   28.70 28.70;
#=GF TC   28.80 31.90;
#=GF NC   26.60 28.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR035321;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family of unknown function is found in Caenorhabditis.
#=GF CC   Members of this family are predicted to contain 4 trans-membrane
#=GF CC   regions.
#=GF SQ   30
#=GS A0A8R1HLZ7_CAEJA/1-105    AC A0A8R1HLZ7.1
#=GS B6IHL7_CAEBR/1-177        AC B6IHL7.1
#=GS E3LSC5_CAERE/9-128        AC E3LSC5.1
#=GS A0A2G5UHB9_9PELO/1-177    AC A0A2G5UHB9.1
#=GS G0MK63_CAEBE/1-184        AC G0MK63.1
#=GS G0MK62_CAEBE/4-179        AC G0MK62.1
#=GS YLH9_CAEEL/3-177          AC P34363.1
#=GS G0MK60_CAEBE/1-154        AC G0MK60.1
#=GS G0MK59_CAEBE/1-184        AC G0MK59.1
#=GS YLH7_CAEEL/1-153          AC P34361.1
#=GS A0A2G5UHL6_9PELO/5-174    AC A0A2G5UHL6.1
#=GS A0A261C6U2_9PELO/1-151    AC A0A261C6U2.1
#=GS E3LSC6_CAERE/5-188        AC E3LSC6.1
#=GS A0A261C6P8_9PELO/235-413  AC A0A261C6P8.1
#=GS E3LSC4_CAERE/1-179        AC E3LSC4.1
#=GS A0A2G5UIA9_9PELO/1-186    AC A0A2G5UIA9.1
#=GS A0A261C6V9_9PELO/5-188    AC A0A261C6V9.1
#=GS A8XA96_CAEBR/1-151        AC A8XA96.1
#=GS A8XA93_CAEBR/1-186        AC A8XA93.1
#=GS A0A2G5UHD3_9PELO/3-156    AC A0A2G5UHD3.1
#=GS YLH6_CAEEL/11-169         AC P34360.1
#=GS A0A2G5UHA3_9PELO/4-165    AC A0A2G5UHA3.1
#=GS A0A2G5UHB1_9PELO/1-151    AC A0A2G5UHB1.1
#=GS YLH0_CAEEL/1-179          AC P34364.2
#=GS A0A261C6T5_9PELO/1-175    AC A0A261C6T5.1
#=GS E3LSC9_CAERE/1-175        AC E3LSC9.1
#=GS E3LSC8_CAERE/1-104        AC E3LSC8.1
#=GS A0A2G5UHY7_9PELO/5-183    AC A0A2G5UHY7.1
#=GS A0A2G5UH99_9PELO/1-165    AC A0A2G5UH99.1
#=GS A0A8R1IMR4_CAEJA/1-50     AC A0A8R1IMR4.1
A0A8R1HLZ7_CAEJA/1-105               .........mqvhfcai-------------------------..-----------------.----....--....-----....------------------------------LFALVMTL...FGFGITGALYLYTLIKS....KDGR.......--FGDDGEL.NRL...IANFIILVSL...LFYIWMCYKL.VKAVKR.KTVHLP.EFDTTQGLYQFNRDAYDGVETVTLNY........................
B6IHL7_CAEBR/1-177                   .................MAHFYEP-RDSRLSKAPLCCCCIPI..KFIVLLVQVLALVFQI-.WLLC...aEK....TSNVM....LFVKVLLAVYTAFTFGVFLIEHKSLMNFHCFLGVICLL...APFA-HVALEYFASAKK....LFLH.......YDYSPKTDV.--F...VIVGIIMLVV...LVYLTMCRAL.VNELN-.KQNQLPsYVAATQPSFNTEYMP-ELTEKTKLIH........................
E3LSC5_CAERE/9-128                   .............lakk--------------KGPMFFGVLPM..KSVILFMQFLAIFYQTYqFQDC...fGC....FLSTV....YLIRIILIAVSFIGFIGYLLDRKTVMKVHLWTTIFVLA...IPVAIIQIGVFLY----....----.......---------.---...----------...----------.------.------.--------------------------ctflyicwtissehvisledvlqk
A0A2G5UHB9_9PELO/1-177               .................MAHFYEP-RDSRLSKAPLCCCCIPI..KFIVLLVQVLALVFQI-.WLLC...aEK....TSSGM....LFVKVLLAVYTAFTFGVFLIEHKSLMNFHCFLGVICLL...APFA-HVALEYFAHINK....FFLH.......RDYSPKTDV.--F...VIVGLIMLVV...LVYLTMCRAL.VNELN-.KQNQLPsYVAATQPSFNAEYMP-ELTEKTKLIH........................
G0MK63_CAEBE/1-184                   .................MVKFYDPNQPEQFLEVPKLCGVFPI..KVLVLAMQFIVMLFQIA.CLCV....FD....SSKTI....IFFQITSIVLNAFTFAAFIVENKILIRTHYYAAAIFTI...VPIGFVLFSIILMFDVI....FFGNr.....lLTASPFEST.FYL...IAGILVLCAY...IFYITMCRRL.IKAFDR.QPEDLP.ELDTTQGLFTFNRDAYDGAERVKLIY........................
G0MK62_CAEBE/4-179                   ................k-PKFQDLKQSQAIKEEPKFVAFLDNadKVFVLVLQAVLLGHLIYqYVVD....EV....YASKE....WISSSIAIGFLAIIFIAFLFEKKSIIVAYSYSLALMAA...IPIGRIELLAADILKKL....FNPDap..vldGPNAMWNAS.III...MWNLIILLAL...GLYLSVCFAV.IDNIDL.KKK---.--------------------------kksmtlphtvqnvil.........
YLH9_CAEEL/3-177                     ..........nnysidl-------------KQGPSLLYVIPI..KPVVLAVQLGAILFQFK.SIYD....FE....YNFVG...dLVFRTFVIFLSLTSFTAFLFNQKILMKAHLVMAIFLLA...GPIACLQYLVFDFYRAE....FHGDnn..lkwDHTSSFENY.LIF...ILVILLAVAL...GSYTWLCHLL.IEGLDE.KN----.--------------------------apkrrpqckicsnhyvvpenekl.
G0MK60_CAEBE/1-154                   .................MSKFYET-HFSRSLDSPLLCGCFPI..KPIVLAAQLLMTIFFIH.DLVGt..aSS....ADTVS....IMGKVFMIIFLVSSFVAFLADYEVLMRLHHLVSCVVAL...IHIA-WFFMELFSFIKK....VASE.......-TPINSSDV.KVL...LVPIGYSFVF...VLYIWMCQQL.IMVLG-.------.--------------------------rkyilp..................
G0MK59_CAEBE/1-184                   .................MPSYYNPHHPN-VYESPKICCCIPI..KLIVLAIQAAALVFQVY.QICCgierSP....SDKGA....LFLQFLAALYTGFTFVVFLINHRCLMCTHFCFGICLMM...IPLGFFVYYSFFVVLPG....VLGL.......IDRVGANDI.EQF...FAAGFCILVL...FSYIVMCKVL.IDSLNH.SP-LLP.EH------------------------iinqntqqpghiggghsegsqliy
YLH7_CAEEL/1-153                     ...........mthfet--------RPLCSLNSPLLCGFFPI..KLAVLLVQLIAIVIQFC.MLYY...nGN....QEEIV....FVAMVLLLVFTISSFVAFLGEYGTMMAIHYYVSCILLI...WPAVVF-IMKLISLCNK....LFIE.......-ENATSRDA.KDF...MKITAILFAV...IFYIWMCLQL.IRVA--.------.--------------------------ksrlilpr................
A0A2G5UHL6_9PELO/5-174               tkfshpqksekksnmsw------------------------T..KSFVFSVQAVFLFLQI-.WALAh..fDF....EKNTQ....LIPRLIMLIVSAIVFIGFLIEQKIIMTVHILFMASFLA...WPIFLLQATILSLFKSLegkaAFIN.......TEGPSTGSMvETS...VTLFLFSLLN...LVYIACCYNLlVDIKHG.HPEVLP.YNSK----------------------vhgssqasek..............
A0A261C6U2_9PELO/1-151               .................MSNFYQT-RVINSMESPMLFDLFPI..KLVVLVVQAVTLLLNIG.FISK....LS....LERGD....FIFEICIILFLVASIVAFLADYELLMHIHYWVVCVLTI...IPLIYWGIAVKELYDSI....--GS.......-SKIAVN--.-GI...ISQTLVLLAY...VIYISMCRRL.IKSLGR.K-----.--------------------------yvlpmfn.................
E3LSC6_CAERE/5-188                   ....tkfndsksapnvv-----------QKKKEPMLLG-LSV..KHLILLYHVVFFLVQIDsFIHI....KD....KKFND....IVWGIITVICISGSFYGILTENKKYIKFHYWYCIFVSA...IPVAFLQLLSVGIIHRL....VTGEe....gfLSGEIMCAL.KAF...GYVLGFVMIF...FLYIWMCYKL.HKHLAN.HSMVLPySAKDVHVIYNPNYDAN----------hhsins..................
A0A261C6P8_9PELO/235-413             .................MPKFYDPNQPEQYLEAPTFFGVFPI..KKVVIVMQIIWLSLQIA.FLSF....VD....MAPLL....ILANIVSIVLCAFVIAVFVVENKLLMRIHYWNALVFIF...VVMGVLLLGATCILWNV....SAGS.......---FELKFL.WYW...IGGLIFLCAL...ILYVSLCRKL.IRALDQ.QPDNLP.DLDTTQGLFHFNRDAYDGSERVNLIY........................
E3LSC4_CAERE/1-179                   .................MPKFYDPNQPEQYLKAPTLFGLFPI..KKVVTVMQIIWLSLQIA.FLSF....VD....LAPLL....ILANIVSIVFCAFVIAVFIVENKILMRAHYWSALVFII...VVIGVLLFGTTSILLNV....SAGN.......---FELKSL.WYL...IGGLIFFCAL...VIYASLCRKL.IRALDQ.QPDNLP.DLDTTQGLFHFNRDACDGSERVNLIY........................
A0A2G5UIA9_9PELO/1-186               .................MAKFYDPSQPEQYLSSPKLFGVLPI..KLIVISMQILYMLLQIV.WLTA...sDV....TSKVS....ILLVIASVILTAFTVAVFVVENKSLMQAHIWAASLFLF...VPLAVFVLIIAQFFFDI....KFLAt....flGEGIYTHPI.TSV...VVAAVFLCAY...IAYLFLCHKL.VEAKDQ.QPDDFP.ELDTTQGLFHYNRDAYDGSERVNLIY........................
A0A261C6V9_9PELO/5-188               .....tkfsdsksepnv----------VQKKKEPMLLG-LSV..KHLILLYHMVFFLMQID.SFIR....TN....KKLGD....IVWGIITIICISGSFCGILTENKKYIKFHYWYCIFVSA...IPVAFLQLLSFGVIHRL....VTGEe....gcLSGEMVITL.KAF...GYVFGFVMIF...FLYIWMCYKL.HKHLAS.HSMVLPySAKDVHVIYNPNYDAN----------hhsinsh.................
A8XA96_CAEBR/1-151                   .................MSNFYER-RVLHSMESPMLCDFIPV..KLVVLVVQIATLLITVG.VISR...nVS....LSSES....AMFEIFVVVFLVASVVSFLADYELFMHIHYWVVCVLII...VPLY-YWGQSIVNLYNH....IFNN.......---SESPAV.FSF...ATSTFILCSY...IFYIWSCRQL.IISLG-.------.--------------------------rkyvlp..................
A8XA93_CAEBR/1-186                   .................MVKFYDPSQPEQYLSSPKLFGVLPI..KLIVISMQILYMLLQIV.WLTA...sGV....TSKVS....ILLVIASVILTAFTVAVFVVENKSLMQAHIWVASLFLF...FPLAVFVLMIAQFFFDI....KFLAt....ffGEGIYTHPI.TSL...TVAAVFLCAY...IAYLFLCHKL.VEAKDQ.QPDDFP.ELDTTQGLFHYNRDAYDGSERVNLIY........................
A0A2G5UHD3_9PELO/3-156               ...............wt-------------------------..KSFVFSVQAVFLFLQI-.WALAh..fDF....EKNTQ....LIPRLIMLIVSAIVFIGFLIEQKIIMTVHILFMASFLA...WPIFLLQATILSLFKSLegkaAFIN.......TEGPSTGSMvETS...VTLFLFSLLN...LVYIACCYNLlVDIKHG.HPEVLP.YNSK----------------------vhgssqasek..............
YLH6_CAEEL/11-169                    .......ekskatisfw-------------------------..KFIAMFIQALFLIGLVEdLCYY...hMF....YSRQY....FFLEILVTIHTGFSFIVFLIEHKPLIMLHVGYMTLLTI...IPIA-YMVMQGVEFGIL....IFDD.......YHILVFRDF.HKF...GCSIMFSLYY...IGYIVVCFLF.IEALEK.KP-VLP.QVYSI---------------------kpklvaavnpsnn...........
A0A2G5UHA3_9PELO/4-165               .......isrppklmtw------------------------I..GAIVYSVQALFLIFQF-.WEYV...nKKydpnQSHMQmiieLIRRIVMIFISGIVFVGFVTEEKVIMKIHILFMTSLLA...IPIT-TLFATVFSFFKS....LEGG.......A-MLINNDG.AKC...INIEGVMCN-...LLYITFCYIL.LADIKYgHPGVLP.Y-------------------------tskvhgssqdsek...........
A0A2G5UHB1_9PELO/1-151               .................MSNFYER-RVLHSMESPMLCDLIPV..KLVVLVVQIATLLITIG.VLSR...sVS....LSSES....AMFEIFVVVFLVASVVSFLADYELFMHIHYWVACVLIL...VPLY-YWGQSIVNLYNH....IFNN.......---SESPAV.FSF...ATSTFILCAY...IFYLWACRQL.IISLG-.------.--------------------------rkyvlp..................
YLH0_CAEEL/1-179                     .................MSKFYDPSQPEQSYDSPKLFGIIPI..KFIVSFLQLVSIVSQIL.WLY-....SE....NDKIY....LVLLSVGIVLNVFTVVVFIKEHKLLMRAHYYSALIFTV...VPFI-YAVYTFISFIEL....FFGD.......-KDITFNQC.SPF...AYAFIFLCIY...IFYLAMCRVL.IKASEF.QPDDMP.DLDTTQGLFHYNRDAYDGGERAKLMY........................
A0A261C6T5_9PELO/1-175               .................MPRVYDA---SSYSEPPKVC-CIPV..KLVVLVMQIAALILPIA.SICF...aRK....QESHL....LFGQVLWAIYFGLSFVAFLVEHKGLMVLHCFFGIVSWVgscVVLGLDYFKIRVLSDEL....FFDE.......--QFFSNSV.-LL...VGTGILLFVA...LFYVIMCRAL.VRSLDS.E-PVLP.DYNTA---MQQPSCPVDTSEHTKLIY........................
E3LSC9_CAERE/1-175                   .................MPRFYDA---SSYSEPPKVC-CIPV..KLVVLFMQIAALILPIA.SICF...aRN....QESHL....LFGQVLWAIYFGLSFVAFLVEHKGFMVLHCFFGIACWLgacVVIGLEYFKIRVFSDKP....IFNG.......--QFFSNSI.-LL...VGTGILLFVA...LFYIIMCSAL.VRSLGR.-EPVLP.DYNTAM---QQPTCPVDTSEHTKLIY........................
E3LSC8_CAERE/1-104                   .................MSNFYQT-RVIHSVESPMFFDRFPI..KLLVIVVQVVTLLLNIG.YMSQ....PS....LERGV....FIFEMCINLFLVASIVAFLADYELLMHIHYWAVCVGTI...IPLIFW-----------....----.......---------.---...----------...----------.------.------.--------------------------glavkdlf................
A0A2G5UHY7_9PELO/5-183               ..tkfshpqkvekesnm----------------------SDI..KAFVFAVQATFFIYQI-.WKLA...hFD...yEKHIQ....LIPRLTMLFLSAVVIIGFLKKQKIIMTVHIWFMASLMA...WPIFMLHAVVFMFFQSL....EDGDlfinsggDTGINMTGY.MYLklaTAVFIFFLVTlgnLVYIALCYIL.LDDIKYgHPEVLP.YTSMMHGSYQ----------------dsekl...................
A0A2G5UH99_9PELO/1-165               ..............msd------------------------I..KAFVFAVQATFFIYQI-.WKLA...hFD...yEKHIQ....LIPRLTMLFLSAVVIIGFLKKQKIIMTVHIWFMASLMA...WPIFMLHAVVFMFFQSL....EDGDlfinsggDTGINMTGY.MYLklaTAVFIFFLVTlgnLVYIALCYIL.LDDIKYgHPEVLP.YTSMMHGSYQ----------------dsekl...................
A0A8R1IMR4_CAEJA/1-50                ................x-------------------------..-----------------.----....--....-----....--------------------------------------...-----------------....----.......---------.---...---------L...LFYIWMCYKL.VKAVKR.KTVHLP.EFDTTQGLYQFNRDAYDGVETVTLNY........................
#=GC seq_cons                        ............................p..csPhhhshhPl..KhlVlshQhlhllhQIh.hlht....hs....tpph.....llhplhhllhsuhohluFLhEpKhlMphHhahsslhhh...lPluhhhhhhhhhhhph....hhss........p...hssh..hh...hsshlhhhsh...lhYlhhChtL.lcsls..ps..LP..ht...............................................
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