#=GF ID   DUF5378
#=GF AC   PF17349.6
#=GF DE   Family of unknown function (DUF5378)
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   PRODOM:PD024151 
#=GF GA   25.70 25.70;
#=GF TC   50.20 49.00;
#=GF NC   22.10 20.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR035319;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This is a family of unknown function which is found in
#=GF CC   Mycoplasmataceae.Family members are predicted to contain 7
#=GF CC   trans-membrane regions
#=GF SQ   20
#=GS A0A858U859_9MOLU/5-202    AC A0A858U859.1
#=GS A0A449AW32_9MOLU/9-284    AC A0A449AW32.1
#=GS A0A084U4L3_MALIO/1-201    AC A0A084U4L3.1
#=GS A0A4R0XSC6_9MOLU/11-297   AC A0A4R0XSC6.1
#=GS A0A084U3S3_MALIO/14-138   AC A0A084U3S3.1
#=GS Q7NC36_MYCGA/9-289        AC Q7NC36.1
#=GS A0A857DBX9_9MOLU/4-267    AC A0A857DBX9.1
#=GS A0A449B4I5_9MOLU/9-264    AC A0A449B4I5.1
#=GS Y135_MYCGE/9-277          AC P47381.1
#=GS A0A292II86_9MOLU/5-301    AC A0A292II86.1
#=GS A0A292IHT4_9MOLU/228-476  AC A0A292IHT4.1
#=GS A0A507SQN1_9MOLU/12-276   AC A0A507SQN1.1
#=GS A0A4R0XL55_9MOLU/16-146   AC A0A4R0XL55.1
#=GS Y276_MYCPN/10-285         AC P75501.1
#=GS A0A097STN5_9BACT/23-287   AC A0A097STN5.1
#=GS A0A449AZW5_9MOLU/2-224    AC A0A449AZW5.1
#=GS A0A857DB33_9MOLU/1-218    AC A0A857DB33.1
#=GS Q9PQ80_UREPA/14-305       AC Q9PQ80.1
#=GS Q8EVY2_MALP2/10-281       AC Q8EVY2.1
#=GS A0A084EXL1_9MOLU/13-302   AC A0A084EXL1.1
A0A858U859_9MOLU/5-202               fllllitficllsipllkysikwrkyksddwllknn-------------..-----.......-KLNLKWIINLIIGVT.FLIYFLTIRWLPDLKNL.KTMDIKHSVGMSDY--EL.....YKYSYTYSKVFLLDWCPFFSIIFAIIAIFDRKMR.IIHFFGFIVFCFGTLTIIGGFI-..-ENKNLNW.SNFFEYVTIG.IK..........PNSIYFGLHFFMAFFGLYNFALLK...K-.------.-.------------------------------------....---------.-.---..-...-...----...........----------..-.-----.--.............------------------------------dplktnfnflcylf.......................
A0A449AW32_9MOLU/9-284               ...................................f-ITFFTAATMLII..NKKFK.......KYLDKYW-VRVTAGLV.FLTYIVLFRFVGNWSEIaNITAHKMPGWWHETFH-D.....Y-RSYVLSRSLFLDLCPFFTFALLLTMIFDRSKY.SSFIVSPFCLFASAIVI--PFV-..-PATEKNF.VFSLKYLLIA.TK..........EFRLYFFMHWFMFNFGCLAFVNYSl.eNV.SYKRIFrD.IQITLLVFASYIIIISYIF--NIDKNTTGLSRKDWE....KG-GSFYAI.S.KGL..R...V...PHPY...........QAVLFYIFSI..AwINFIP.L-.............VKYDLQNEIIIGKFIQKIKS----------kmqqwkrsla...........................
A0A084U4L3_MALIO/1-201               ....................................-------------..-----.......----------------.-----------------.------------------.....--------------------------------KN.MAKILCPFSIIGSIITI--FFVV..STDKDISG.-NFWKYIFIG.TY..........PNVLIFLLHYINLLFAVFVLLTSK...QF.TKWSMV.S.MILFMLIYFGYISIFINFF--GVGFNTTGLSKNDWFnsidSSYSEYGSV.Y.NLL..P...I...GFPS...........APIFWFTLAT..-.--IVA.YL.............FIYI-KNITTKDINKKYNRSK---------rwyseidylniillpieikldkffdkfklkltkk...
A0A4R0XSC6_9MOLU/11-297              .................................vsi---CIILVSILIFkkDKLRK.......VLEKKT--FWIIFNTV.WIAYFVGARYIPY---I.VQ--------SSRGFEGS.....IAKSMLFQNIFMTNVCPMVTMTIAIGSYFKRFRNnFGPSIGIIALFGGVMNMIAIIM-..NSN--TEN.--LFSFLFFK.TTvsyinpaetlDNYLWFMTHLILIVQGILLLIMCK...KI.TWKNVI.L.LYIWSFSFMIYIAIIMA--STGIRNDVAGLWINDWI....Q-VGNYKGV.FyQIG..S...I...IWPAqthgatsvaktISGIILLYSF..-.-GVVF.IV.............LSWYFINFENKHYKWQK-------------ffgkfkknnkkavstn.....................
A0A084U3S3_MALIO/14-138              ....................................IVTVLSVTTMILF..HYFVTlkynrvyRVINSYW-FSIVISII.WLIYFIVVRWSGDIKVL.IDQPLSWSQWKSNDY---.....YNYSYSISRVFLLDLCPMIGLVLPIFLIVDKTKN.MAKILCPFSIIGSIITIF-----..--------.----------.--..........------------------------...--.------.-.------------------------------------....---------.-.---..-...-...----...........----------..-.-----.--.............------------------------------f....................................
Q7NC36_MYCGA/9-289                   ....................................IIVSLWLLLIIAT..SKFFI.......RFENNYW-FWFFIGGF.MFFYMIIGRQI------.-QFLIPG--WNAADYNSP.....FAVSIRHSRLLLLDICPFFAIFAGFGLMVTKNKL.IIRSAAPIALFGGLINLYGELFR..LANQYTGK.LEAYRFIFIG.IG..........NDQLYFILHVMTTTVALMLICWTT...KW.TPRDIL.N.QYLFIAIYACYVLSSIQ-LDRKITNNANGILIADWY....IG-GEYQSV.S.KIL..R...V...PFPT...........VIPVGVVITM..-.-VSIT.LIwamrygvqelnarIIYPSLAKKQTKFDLKYMWKNLKYNYLKRR.....................................
A0A857DBX9_9MOLU/4-267               ...............................fifvf-ITFISILIGSLL..IKFFP.......KINNRYT--QIAWSLI.FLIYFIIFRYSIDIKEL.ITIYQDNNPSLNARY---.....---SGIMSRIFFLDWCPAFALLISFAYLFDNKGR.VIYIFSIMSIVGGYITL--PTIP..LSETIDHI.--TLKYLFIG.TD..........VNRLYFLMHWYLAVSGTISFIFYT...KP.KYSDVI.Y.AHITAALYFIYV-AFIS-LSLDVLHNVTGIRESDWR....PG-GEYENV.I.PIL..K...V...DFPY...........VIIVGFGMAY..-.IFINS.SLlikaa..lhkhkkHIYHY-------------------------fknikkss.............................
A0A449B4I5_9MOLU/9-264               ...............................atfsf-----FILIVLIS..YKFKE.......ILLNHAS--KILIGIF.MLAYFSILRWVPNIKDF.INNEN-------------.....-PSSISISRTFLLDLCPAMFVALSLVLVFDFKNK.LLPYFSVAAFICGFITYIFVPITesYVVKDSSS.LLDYKYLFIG.TD..........ANKMYFMMHYQLMLFGFIYFILTP...KF.KLITLF.N.ISTGLFIYMLYV-IFISRL-YNVTQNATGLVEFDWS....-EYGEYSV-.-.--L..G...S...KFGN...........NIWLN-SFIY..-.IIVFS.ILc..........llIRISIYPIIFTKKSILLKKEL---------kki..................................
Y135_MYCGE/9-277                     ...................................iILIIAGVISVLAF..TPLVR.......KLKIRFYLIQVLAIVL.FVYVFFGRQIIYLFPDV.YGQNSQS---------SQ.....NLDSLRLSRIFLLDLCPFFAVIAPVF-VFLKQKK.ISGVLAVFGLFGALVTLFGELIF..TPVNEQDI.---VNFIFVG.TG..........NNQIYFMMHFLSLLVSLAIILWDN...CF.SLISFF.Y.IHVFALIYFSYVALMVSVFKGQITGNTTGILASDWT....--NGEYKNV.A.TFL..N...LsnsDPQL...........VFIVGFSLSY.vA.ILLMT.LF.............ANIPTFMEMKKDKIFIKKEN----------lirkdle..............................
A0A292II86_9MOLU/5-301               ..........................iifvfviatp-------ALFIIF.iSPKTK.......KIASNQW-FWIIVGLIgFGYAFFGRQLQYLVPEL.RGKILYD--LFGSPLMPPpdpnrPLEGLDYSRLLLLDLCPFYIIFGSLS-LFLKKKK.IAQILAPFGFYGAAITLFGQIIH..DVGNPVNYpKGIWIYIFVG.YH..........GGELYFMIHYLSMLISLMVICWTT...NW.KKTLLI.H.MHGFALFYFSYILIMVA-LIPKIMGNTTGVLEADWQ....QG-GEYSRV.E.QIL..K...I...KWPA...........VMIVGYIISY.iV.IAIVS.LT............rI-----------------------------gieiwarswrskvhlrlleldwyknlsakwykfkckk
A0A292IHT4_9MOLU/228-476             .................yyltnlyhgfaqeqftvvr-------------..-----.......----------------.-----------------.----SSNAIVSDQKYIDQqt.qlWVHSFVYSNVLLTPLCQSLGLIFPATLVLSRKKD.YATIVAPWAFLGGIVTLFGGIA-..-SDHNIHI.--SLQFIFYD.--..........-QQMFYLYHSFIFITGLCWFVYSQ...RY.SFVSMT.S.TYFYMGGYLIWIVIVANIF--NIRYFTTAITSLDLS....V-SGSYGIVnS.DLL..KdtlI...EYPG...........NTLLMFFVFA..T.IITIA.IIvk.........nlIHYYFFKKNLHDVS----------------dsyfndikqtykfakeh....................
A0A507SQN1_9MOLU/12-276              ...................................k-ITTIWVKNTQNSvlLKLSK.......HKTHLKFLLWQLSGIF.FFVYLIYFRFWNDWRIF.FDYIKNT--NLTNNINDQ.....YEHSLKISRALLLDMCPFMSLLLSLFSIFDTKGK.LSSYIAPFCIFGGAISI--NFIP..FSEPDQVI.--NAHYFFVG.SQ..........LNPLYFFMHWYLTVFGILVLRRNK...TP.QLKELI.W.LHLVAFLFYSYVNLMTYQF--NVTYFISGVREYDWI....-GIGEYSGV.S.SLVnnK...I...SFPW...........IMIISFSVVY..-.ILIVSsWI.............LRVYLLRFLNKK------------------htkmsi...............................
A0A4R0XL55_9MOLU/16-146              .................................gdy-------------..-----.......----------------.-----------------.------------------.....----------------------------------.-----------------------..--------.----------.--..........-----VGAHFLQIIIGCMALIVAP...KI.TWKDAI.K.SIIFIFLMMAYI-AIIY-WMTNITMQTTGIAEGDWR....KG-GEYNIV.P.TVL..N...M...NNQS...........IHAIRFV-GW..M.IFIVA.QL.............I-LTYIIILCQKADKKY-------------cnkfpegfiykytkp......................
Y276_MYCPN/10-285                    ....................................ILTVAGVLVILGF..TPLIR.......KLKIQFYCLQVFAAIL.FLYVFFGRQIIYIFPDI.YGTAAKAKNAVANV----.....PLDSLRLSRIFLLDLCPFFALIGPIF-IFLRQKK.VAGVLAIFGFYGAAITLFGELIF..TPLKQEEI.---VKFLFVG.LE..........NNQVYFMMHFLSFLLSLAVFLWDD...GF.SLISFF.Y.IHVFALAYLSYVALMVNIFKGQITGNTTGILAEDWL....--SGEYKNV.A.VFL..K...L...DPKNa........dlIFGVSFGLSY.fA.IVLLT.VL.............VNIPTFIQLTKDKQMVKLALQLKKAQASV-a....................................
A0A097STN5_9BACT/23-287              .................................lvg---IVWLTTILIFavHPLTK.......RWTNSYLAFWIPWGIL.TTVLSLVFRFIPDW---.-IE--HISNWATNGYN--.....GIDSFDLTRIFLLDACPMICVLNMFA-CFIPNRK.FGQAMAPISIFAALLTL-TTFI-..-PGSEDVF.--SLKFLFTGpDR..........ENRGFFLIHFLNLITSCVFLLSGP...RM.TWRKFF.TrTNLFVFSYLGYVAIMIAIFNGKLNQNATGLVPGDWL....PG-GEYSFL.G.KII..G...L...GFPL...........DPIIAFVFCY.lG.LMIIT.FI.............AIVLT-------------------------rmkpynvpgivndrdwww...................
A0A449AZW5_9MOLU/2-224               ..........................qlgdlfkhrt-------------..-----.......----------------.-----------------.-----PE-NWQGT-YNE-.....-YYSYVLGKSLFLDLCPFFTFALLFTMIFDKTKY.ASFVISPFCIFASILVI--PFVP..MTEKGATF.--SFKYIFIG.SD..........VFRLYYFMHLFLLVFGVLAYKNYSlkgKK.LLNVWL.D.LQLVAIIFFSYVIIMS--YALDIDQNTTGISRKDWE....KG-GSFYAI.H.KNL..K...V...PHPF...........EAVIFYLLSY..-.LVINS.LL.............L-IKYYINNYSFKEWVKFK-----------lkrnqqla.............................
A0A857DB33_9MOLU/1-218               .................................mip-------------..-----.......----------------.-----------------.--------EWFKDKYPEDt..itMFRSYTLSKSLFMDLCPFFSIALCVSMILDKTKR.WAFLVSPFCILGGLIVM--PLIA..TIEKDQYF.--TPKWVFVG.TN..........ENRLYFLMHWFLIVFGSLAFVNFK...NIvYKKDLL.A.IHIIALIFFAYVIFNAYVL--NIDQNVTGVKIKDWY....--EGDYKGV.R.KLL..N...G...KWHL...........PLWLTITLTYmtAyGFVVG.LF............sARYYFV------------------------knkilakeqplklqys.....................
Q9PQ80_UREPA/14-305                  ....................................CITCIGLANFLIK.pIQIKKhnwltwnYFINTKWIINTLISIS.FLIYFCCLRWAPNIHVF.FINHIEIINVLRDKFSDDi..dlYEASITISRTFLLDWCPCFSVLISCVAIFDKKQI.IINHLGFLCFCFGLLTIIGGLI-..-GDEPIRW.NRLITYIFIG.DK..........PNPIYFSLHFYLCLFGFYLFVNTRktiKI.YWIYII.-.IHIILITYIIYVNVMILIF--NIKNNASGFSFGDWY...sPIYAQYGTV.A.QFL..Q...L...NYRL...........NALIMCLFMY..A.IFIVG.YL.............IRYHLQKIYINKYNIKYSQERNYFAYVKNC.....................................
Q8EVY2_MALP2/10-281                  ....................................SISLIIVSLTFLF..NFFGK.......RLVNNYW-FWAIPSLL.FLIYFIVFRFYGAWRDL.NQFLQTNSIWLGNELN--.....YEDSIIVSKALLLDMCPFVAIALPVSLILDKTRR.IANAISPFAILGAGITI--PFIA..YSDPEAAI.--SFKYFFVG.-G..........FLPIYFFMHLYLLTYGVMVFSNSR...NR.KWIHLL.D.CHIFAAIFFGYV-CFVS-FTTKTVWNVTGINANDWE....SSLGEYNMV.S.QIF..N...L...PFPS...........VMVISFLLAY..-.IFVVS.IV............sINIYWKKKHQKDFKVIKLKYLKNSKNLKSK.....................................
A0A084EXL1_9MOLU/13-302              ................................ivsc-LSVAVLTNCFRV..KKLYLynwwkknYYINTKYLINLLISIG.YLAYFISLRYS---KDV.EQFIAHKDLIYSDPFNLYde.llYFRSFRISKVFLLDWCPCFSVIISLFAIFDYKQK.YVNLMGLIGFCFGFITLIGGLI-..-GQERIEV.DQFWTYVTVG.VG..........LNQIYFGLHFYLCIFGLYLFSNLR...RF.DVANIS.L.FHAVLISFMIYVPISVH-F-WKVTNNASGYVMGDWIp.lqGSLAQFEIV.G.KII..N...Q...HFII...........NAFVMFLWMY..L.AFVAG.FF.............AKLYILKTINKKDQ----------------ksysipfvdhkiak.......................
#=GC seq_cons                        ........................................h.lh.hhhh....hhh.......hhhpphh.h.hhhulh.ahhhhhhhRh...h..h..t...p...hhss.h........h.pShplS+hhLLDhCPhhulhhslshlFc+p+c.huthlushulhGuhITl..shI....sspptph....hcalFlG.sp...........NplYFhhHahhhlhGlhhhlhsp...ph.phhshh...halhhhhahsYV.lhlt.a..plstNsTGlhttDWh.....t.G-YpsV.t.plL..p...l...sash...........shhlhahhsY....lhllu.hl.............l.hhhh....pch.................t.h..................................
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