#=GF ID   DUF5393
#=GF AC   PF17371.6
#=GF DE   Family of unknown function (DUF5393)
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   PRODOM:PD116408
#=GF GA   25.00 25.00;
#=GF TC   33.30 28.90;
#=GF NC   19.00 21.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR035155;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This is a family of unknown function found in Trypanosomatidae.
#=GF SQ   12
#=GS Q4D4S2_TRYCC/264-528      AC Q4D4S2.1
#=GS A0A1X0P8C2_9TRYP/270-563  AC A0A1X0P8C2.1
#=GS A4ICL0_LEIIN/102-767      AC A4ICL0.1
#=GS Q38B44_TRYB2/271-576      AC Q38B44.1
#=GS A0A0N0DV91_LEPPY/104-756  AC A0A0N0DV91.1
#=GS Q4Q1V2_LEIMA/101-766      AC Q4Q1V2.1
#=GS A0A3R7LNP0_9TRYP/254-485  AC A0A3R7LNP0.1
#=GS A0A7G2C630_9TRYP/506-595  AC A0A7G2C630.1
#=GS K2LYI7_TRYCR/263-546      AC K2LYI7.1
#=GS A4HNY4_LEIBR/102-767      AC A4HNY4.1
#=GS A0A3R7KSM7_TRYRA/249-507  AC A0A3R7KSM7.1
#=GS V5BUV6_TRYCR/264-529      AC V5BUV6.1
Q4D4S2_TRYCC/264-528                 ...hksrssae--------------------------------------------------------------------------------.-----------------------------.------------------..------------------..----------------------------------------.-.---------------------------------------------------------------------------------------------------------------------------------------------------------------------HVEKWYDAMMTTLIDGVSA.QDSELQAYIHELQRSLAEDERRITGAPLYLLHRPHDAASTTLIHLACVH-----SELPSLELQPGEMFLLLDP--.-------.---LGESLLFDAEPSKLCTLLRRCALVKLTVTQLR---DAERILSCSPWCELCDTVVESVQYHLNNDAFLSVVLEKNSSFLVKLVRWLRGMPAA.EEDGTMVR.-ST.ETRQQEVLG---.----........V..SMANHIIEYAIHF-SSFGAAIAQFIREVVSCTEISEPQLHTWVDRSIIELENKPSAA-----------------------------------vglfal..............................
A0A1X0P8C2_9TRYP/270-563             ......srpsa--------------------------------------------------------------------------------.-----------------------------.------------------..------------------..----------------------------------------.-.--------------------------------------------------------------------------------------------------------------------------------------------------------------------DDVVKWYDVMLKNITNSAQTlTNAKLQNLVMELQQETVADGVRVNGLPIQLLHRPHDTTSSTFFQI-SL----PHIELPHLETQPGEMVYLFGDPG.-------.----EQPLLFDTNPSKIFFLLRRSATTKLTSMQIRDVDKMFASAPWQNLRDV---LVQTMAYYLSDDQFICSVLEKNSSLMVKLIQWLHKDVSE.ADKEENNK.NET.SEEREEKEKNLDeRKKM........G..LLMTANIMNAAVHIAPFSAGVAQFMREMLDCGLLTADHLNPWVKHSVADLEGKSSATV---------GLFAIIVTFALIHRGWELEE-----nare................................
A4ICL0_LEIIN/102-767                 ...........PSSKFIGTAASLLADGFFSFAPLSSTVDKSRSTSYQHRSECQVRDLFTLIMLLFPDCFIAETLPRTLLEMREAEGSVSET.QSSNRAESEVQHPSSVSRVSPPISPTPPI.LPRGRCTPSAQRIQMSVT..EGRGIAVDAESTSNSVDD..ATVGGLQAAPLEGSLGVLTPAKLVTTDAGATDGERLGVSS.A.SASMTANMMPLPIVSAVPLSLDVLDVLLESRRSLAVVLLSLINDALREVQYRQLEQSHTSATATRSTAAARLPSCEGGVLQFSAEVLLTAKLLLMSVISASAVWRQRFSKTMESTKAVLQGAALLPSPPPSPFHVFSELLGEDAEGATPFLTLPVERWSWGKEKDALGQWYDRLLDRLLAATDG.AGVRVDAYLKSAKSTAVSCGRSVSAFPALLLHRPSDGQPAVEMSLASVARLSGSVRLPSLPIQQGELHLLLCPGV.PEGKTGL.LQARGHELLLDATASPTADFFQACVSSAFTEAQLQPSGDAVPRLFRQRFTDLSSTEQGIVTAALCDPATLSVVLEKNAAMLARLTLWCRNRWPP.SLDASTML.AST.TSQSDDVVKENE.GPKA........A..HSIGDQVEQHILFQRPFSAAVGRYVRELVTLRGLSKDVLEAWMRHVCTGADAAAGAAVDGSIPSPHRAMFSALVKFAVLHNRWRLNPEVEAL....................................
Q38B44_TRYB2/271-576                 ersrpgaeevm--------------------------------------------------------------------------------.-----------------------------.------------------..------------------..----------------------------------------.-.------------------------------------------------------------------------------------------------------------------------------------------------------------------------RWFDSTLGALTSTVSG.LFSSLQERLQELLNDVSVDGRRVTGTPVQILHRPHDSTSTNVLQLPFVQ-----SKLPHLPLQTGELATLLSPN-.-------.---PGEMLLCDSVPSPLSLLLRRCATVKMSALELR---DGVEQLAMNPWWALHYAASQTVQRQLSDTQFIRSAVGKNSCFLIEIVRWLRDVPSDeAKDVAKER.GSA.CSNSEGTKQQNG.RTNGesnreqrlLlgLSTSNEIIDHVVHDLPFGTAVAQLIRELVGSNLFTEEQLHRWIGRSLKDVE---------SKPPATIGCFAALLVFVLLHSRWELPADI---rem.................................
A0A0N0DV91_LEPPY/104-756             ...........PSSKCISTLATLLADGFFNMSPLSSTVEKVHGAPHQHRSECEARDLFTLIELLYPDCFVAEALPRALLALRRAESTTPRAwQSSYSAT---------RAVSPSNSPQAAVsLSRGWKSPPAQDARNGDDgfGGEEVAEPAQCLLPSTDPpsSFLVESRSGLPVPLADVHSPTKSSVSELTL-DPAHLANSSvApGAAVLAGMM-VPEVDPVPLAVEGMNDLLACRRSLATVLLSSLNEALHDVQYRELERSRPTA----KERAVPQSSSEAVALRISSEVLLTAKMLLMSVMAASEVWRRRAVKAYT--DAEKSNEATPVSQLPSPYLVLHELFEQDESIAAQFTAIPVEEWTWGRDKESTARWYDQTLDRLLQSTEA.AGVHLDAFLQSSKTFSTQQGEAVSHAPTLLLHRPSDGRPAVELNLSFMDTLNCAVPLPAMPLQLGEVQLLLHPRVvRETKAGVtVSSRGHELLFDAAASPTADFLQSCVSSPCPWTMLQESGGELPAHFRHRFHEFSPSERNMIKTFLEDSHLLGAFLEKNAPMLARVTLWCDGQWPT.STAVSRSGnTDL.GGDASAVVEAAA.TSGG........G..SDLAAEIKDAVMFRRPFNAAVGRYVREMVVLNGFDQDTLERWICHICRN------VACDDAFP-AHKAVFAALVKFAALQCKWTWTSAVDE-l...................................
Q4Q1V2_LEIMA/101-766                 ...........PSSKFIGTAASLLADGFFSFAPLSSTVDKSRHTSYQHRSECQVRDLFTLIMLLFPECFIAETLPRTPLETREAEGSVSET.QSSNRAESEVQHPSSVSRVSPPVSPTPPI.LPRGRCTPSAQRTQTSVT..EGRGIVVDAVSPSNSAVD..AALGGFHAAPLEGSLGVLTPAKLVTTDAGATDGEGLGVSS.A.SASMTANMMPLPIVSAVPLSLDVLDVLLESRRSLAVVLLSVINDALREVQYRQLEQSHTSTTATLSTAAARLPSCEGGVLQFSAEVLLTAKLLLMSVISASAVWRQRFSKTMEGMKAVLQGAALLPSPPPLPFHVFSELLGEDAEGATPFLTLPVERWSWGKEKDALGQWYDRLLDRLLVATDG.AGVRVDAYLKTAKSTAVSCGRSVSSFPALLLHRPSDGQPAVEMSLASVARLSGSVRLPSLPIQQGELHLLLCPEV.QDDKTGV.LQARGHELLLDATASPTADFFQACTSSACSEAQLQPSGDAVPWLFRQRFKDLSSTEQGIVTAALCDPATLSAVLEKNAAMLVRLTLWCRNRWPP.SSDASAVL.AST.ASQSDDVVKENK.GPKA........V..HSIGDQVEQHILFQRPFSAAVGRYVRELVTLRGLSKDVLEAWMRHVCTGTDAAAGVAVDGSIPSPHRAMFSALVKFAVLHNRWRLTPEVEAL....................................
A0A3R7LNP0_9TRYP/254-485             .....rpsaed--------------------------------------------------------------------------------.-----------------------------.------------------..------------------..----------------------------------------.-.----------------------------------------------------------------------------------------------------------------------------------------------------------------------VAKWYDARMQTLIGEVPV.KESEMQKYINELQRALMEDARRIAGAPTSLLHRPHDAASTTLIHLPCVH-----SELPSLSIQPGEMTLLLFDPT.-------.----PESLLFDAEPSKLCLLLRRCACMRLTVPQLR---DAEMLLASTPWSQLRDVVVESVQYHLSNDEFVSLVLEKNSSFLVMLVQWLREI-PT.AVDDNAT-.--A.AGLSEARQ----.----........-..--------------------------------------------------------------------------------------------qaalgasmadhiieyvmysspfwtcqrtvhswvggl
A0A7G2C630_9TRYP/506-595             ....evppfvs--------------------------------------------------------------------------------.-----------------------------.------------------..------------------..----------------------------------------.-.----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.---------------------------------------------------------------------------.-------.----------------------------------------------------------------------------------------------.--------.---.------------.----........-..-----AVEDYVLFEVPFSVMVGQYLRESVSQRSLSREKWGKWLLHTCQKLLNA--SANDGG-SSPHTKVITAIIDFSLAQCSWKLSDE----ekt.................................
K2LYI7_TRYCR/263-546                 ....dhksrss--------------------------------------------------------------------------------.-----------------------------.------------------..------------------..----------------------------------------.-.-------------------------------------------------------------------------------------------------------------------------------------------------------------------ADHVEKWYDAMMTTLIGGVSA.KDSELQAYIYELQRSLAEDERRTTGAPLHLLHRPHDAASTTIIHLACVH-----SELPRLELQPGEIFLLLDP--.-------.---LGESLLFDAEPSKLCMLLRRCALVKLTVTQLR---DAERILASFPWCELCDTVVESVQYHLNNDAFLSVVLEKNSSFLVKLVRWLRGM-PA.TEEDGALV.GSTeAKQQEAL-----.G---........V..SMANHIIEYAIHF-SSFGAAIAQFIREVVSCAEIGEAQFHTWVDRSLTELEDKPS---------ATVGLFALVVAFSLVHRGWDL-------peatr...............................
A4HNY4_LEIBR/102-767                 ...........PSSKFIGTTASLLADGFFCFAPLSSTVENSRTTPYQHRSECQVRDLFTLIMLLFPECFAAEIPPRTLLAMRDAEWSASQV.QSSNHAESEVQHPSPVLRRSTPTSPLPSI.LPRGQCTPSTQRVHTSVS..DGRGIVVDAESLPHSVTD..VSLGGIRTAPLEGLPQLLSPVKLALNDMGASDGEGLGGTT.A.NASVMTNMIALPVVNPVLLTVDVLDVLLESRRSLAVVLLSLINDALREVQYRQLEQSHAASPMTKVTTAARHPSCEAGVLQFSAEVLLTAKMLLMSVISASAMWRQRVSKAMEIRKAALQGAAPPPPPLLSPFSVLSELLGEKTEGTSPFLTLPVEQWIWGKEKDALEQWNDRLLDRLLMATDA.AGVRLDAYLNSAKSTAVSSGRSVSYFPTLLLHRPSDGQPAVELSLASVSRLSDTVRLPSLPIQEGELHLLLCPSV.LENKTGM.LRVRGCELLLDTTASPTADFFQACASSACSEAQLQPSGDAVPWLFRRRLTDLSSTEQGIVVAALSDPATISVVLEKNAAMLARLTLWCRDRWPP.LSDASAVR.PST.ANLSNAITNENG.GPKA........V..YSIGDQVEQHILFERPFSAAVGRYVRELVTLRGLSKDVLEAWMRHVCRGPVVTPGAAVDSTVPPPHRAMFAALVKFAVLHNRWRLNPEVEAL....................................
A0A3R7KSM7_TRYRA/249-507             ....rgrpsae--------------------------------------------------------------------------------.-----------------------------.------------------..------------------..----------------------------------------.-.---------------------------------------------------------------------------------------------------------------------------------------------------------------------DVEKWYDARMHALIGEAFM.KEGELQEYVNGLQQSLAEDERRITGAPISLMHRPHDAASTTLIHLPCVH-----CELPRLTLQPGEMTLLLFD--.-------.--SAGVSLLFDAEPSKLCLLLRRCASVKLTASQLRSADVQLAS---FPWSQLCDAVVKSVEYHLSNDKFLSLLLEKNSSILLILVQWLTKVPTV.VDDATVVG.LNE.ARRH-----EAL.G---........-..ASMADHIIEHVIFSSSFGAASAQFIRGAVGCAALSEALFYAWVDR-----------------------------------------------sltelenkppal........................
V5BUV6_TRYCR/264-529                 ...hkrrssae--------------------------------------------------------------------------------.-----------------------------.------------------..------------------..----------------------------------------.-.---------------------------------------------------------------------------------------------------------------------------------------------------------------------HVEKWYDAMMTTLIDGVSA.QDSELQAYIHELQRSLAEDERRITGAPMYLLHRPHDAASTTLIHLACVH-----SELPSLELQPGEMFLLLDP--.-------.---LGESLLFDAEPSKLCTLLRRCALVKLTVTQLR---DVERILASSPWCELCDTVVESVQYHLNNDAFLSVVLEKNSSFLVKLVRWLRGIPAA.EEDGTMVR.-ST.ETRQQEVL----.G---........-..VSMANHIIEYVIHFSSFGAAIAQFIREVVSCTEISEPQLHTWVDRSIIELENKPSAA-----------------------------------vglfalv.............................
#=GC seq_cons                        ..................................................................................................................................................................................................................................................................................................................................................................................tlt+WYDthhspLlsussu.tsscLpsYlpphppshspstRplouhPh.LLHRPpDutsss.lpLssVp.....scLPpL.lQ.GEhhLLLsP..............hGcpLLhDApsS.hs.hLppCAsstho.sQLp...Ds..hLhpp.ap-Lsss..p.VphtLsssthlSsVLEKNuuhLl+LshWhRsh.ss.spDsstsh..ss.sspppth......t...........h....hsspl.ptllF.psFuAAlupalREhVshptlocs.LcsWlc+shtth.st..ss..........thhshll.FshhpptWph.........h.................................
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