#=GF ID DUF5603
#=GF AC PF18231.5
#=GF DE Domain of unknown function (DUF5603)
#=GF AU Smart A;0000-0002-6965-5633
#=GF SE ECOD:EUF04039
#=GF GA 25.00 25.00;
#=GF TC 81.50 80.70;
#=GF NC 24.10 23.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF WK Domain_of_unknown_function
#=GF RN [1]
#=GF RM 28358477
#=GF RT Structural Study on the Reaction Mechanism of a Free Serine
#=GF RT Kinase Involved in Cysteine Biosynthesis.
#=GF RA Nagata R, Fujihashi M, Kawamura H, Sato T, Fujita T, Atomi H,
#=GF RA Miki K;
#=GF RL ACS Chem Biol. 2017;12:1514-1523.
#=GF DR INTERPRO; IPR040867;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This domain is found in the C-terminal region of free serine
#=GF CC kinase (SerK) in the hyperthermophilic archaeon Thermococcus
#=GF CC kodakarensis. SerK converts ADP and l-serine (Ser) into AMP and
#=GF CC O-phospho-l-serine (Sep), which is a precursor of l-cysteine.
#=GF CC The domain is not conserved in the ParB/Srx family. The
#=GF CC differences between SerK and the other members of the ParB/Srx
#=GF CC family is concentrated in the C-terminal region, which may
#=GF CC include residues involved in the Sep binding [1].
#=GF SQ 6
#=GS A3DM02_STAMF/106-210 AC A3DM02.1
#=GS C6A2V8_THESM/101-201 AC C6A2V8.1
#=GS Q8U3S5_PYRFU/101-200 AC Q8U3S5.1
#=GS SERK_THEKO/101-200 AC Q5JD03.1
#=GS B8D503_DESA1/107-213 AC B8D503.1
#=GS F0LL72_THEBM/101-201 AC F0LL72.1
A3DM02_STAMF/106-210 TWYPAIIGSINKLLEEIKKEGIRIEECKGKDDVLKDEE...LGKYAFVIIGKNNECYKIYGSINEQKIVSKILSKLNLEGEYTLVYYGEKDEALRDLEEGKIDYLFLR
C6A2V8_THESM/101-201 TWYPAFKGDLNKVIERLKAEGLEVLEDKEAEEK---AE...RGEIAFALVG-KEKTFTIPGALNEQKKVSKVLDEMSVEGEIELIYYGLKEDAREDMEKGEIDYVFIR
Q8U3S5_PYRFU/101-200 TWYPAFKGDVNKVIERLKAEGLEVIEDEKAEEK---AE...KGEIAFALIG--EKSFAIPGGLEEQKKVSKVLDEMDQAKEIELVYYGLKEDAKADMEKGEIDYVFIR
SERK_THEKO/101-200 TWYPAFKGDLNEVVERLKKEGLEVIEDPEAEEK---AE...RGEIAFALVG--EKSFAIPGGLEEQKKVSKVLDEMSVEGKIELIYYGLKEDAREDMAKGEIDYVFIR
B8D503_DESA1/107-213 TWLPGIIGEVEPVLSEASRRGLKISMCNYDPNTLGEIDvklLEESSFIVLG-KNLCRAISGGIEGQKIVSQVLNELNMKGLFTLVYYGELSDALEDLKSGWLTYLFIR
F0LL72_THEBM/101-201 TWYPAFKGDLGKVLERLKKEGLTVEECEDAEEL---AE...KGEIAFALVG-KDKAFKILGGLKEQKIVSKVLDEMSVEGEIELIYYGLKEDAKEDMDKGEIDYVFIR
#=GC seq_cons TWYPAFKGDlNKVlERLK+EGLcV.EsccAEEp...AE...+GEIAFALlG.p-KsFsIsGGLcEQKhVSKVLDEMslEGEIELlYYGLKEDA+EDM-KGEIDYVFIR
//
