#=GF ID   DUF5617
#=GF AC   PF18493.5
#=GF DE   Domain of unknown function (DUF5617)
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF04423
#=GF GA   26.30 26.30;
#=GF TC   26.90 26.50;
#=GF NC   26.10 26.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   27986836
#=GF RT   Diverse mechanisms of metaeffector activity in an intracellular
#=GF RT   bacterial pathogen, Legionella pneumophila.
#=GF RA   Urbanus ML, Quaile AT, Stogios PJ, Morar M, Rao C, Di Leo R,
#=GF RA   Evdokimova E, Lam M, Oatway C, Cuff ME, Osipiuk J, Michalska K,
#=GF RA   Nocek BP, Taipale M, Savchenko A, Ensminger AW;
#=GF RL   Mol Syst Biol. 2016;12:893.
#=GF DR   INTERPRO; IPR041234;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain of unknown function is found at the C-terminal end
#=GF CC   of proteins mainly from Legionella, including lpg0944 from
#=GF CC   Legionella pneumophila (Swiss:Q5ZWY9), which is thought to be an
#=GF CC   effector of the Icm/Dot translocation system from this bacteria.
#=GF CC   This domain folds into an all-alpha structure [1].
#=GF SQ   45
#=GS A0A0W0R1U1_9GAMM/248-337    AC A0A0W0R1U1.1
#=GS A0A0W0YXC3_LEGSP/316-410    AC A0A0W0YXC3.1
#=GS A0A0W1A9D2_9GAMM/505-598    AC A0A0W1A9D2.1
#=GS A0A098G0F2_9GAMM/703-792    AC A0A098G0F2.1
#=GS A0A0W0ZYV5_9GAMM/51-146     AC A0A0W0ZYV5.1
#=GS W0BH84_9GAMM/296-385        AC W0BH84.1
#=GS A0A0W0V896_9GAMM/306-400    AC A0A0W0V896.1
#=GS A0A0W0WI89_9GAMM/234-326    AC A0A0W0WI89.1
#=GS A0A0W0VB83_9GAMM/180-282    AC A0A0W0VB83.1
#=GS A0A2Z5V535_9COXI/463-556    AC A0A2Z5V535.1
#=GS G9ELB6_9GAMM/715-805        AC G9ELB6.1
#=GS A0A222NYS0_9GAMM/700-789    AC A0A222NYS0.1
#=GS A0A5N4CE49_CAMDR/42-119     AC A0A5N4CE49.1
#=GS A0A433K1E7_9GAMM/23-113     AC A0A433K1E7.1
#=GS A0A0W0VUD5_9GAMM/1057-1144  AC A0A0W0VUD5.1
#=GS A0A0W0V9P6_9GAMM/712-803    AC A0A0W0V9P6.1
#=GS A0A0W0VBU1_9GAMM/199-312    AC A0A0W0VBU1.1
#=GS A0A098GJ27_TATMI/306-401    AC A0A098GJ27.1
#=GS A0A378I0S3_9GAMM/816-907    AC A0A378I0S3.1
#=GS A0A378I0I6_9GAMM/311-405    AC A0A378I0I6.1
#=GS A0A0W0VZY7_9GAMM/300-394    AC A0A0W0VZY7.1
#=GS A0A0W0V7R3_9GAMM/702-791    AC A0A0W0V7R3.1
#=GS G9EKV6_9GAMM/266-355        AC G9EKV6.1
#=GS A0A378LSV2_9GAMM/97-192     AC A0A378LSV2.1
#=GS A0A378HZJ9_9GAMM/237-328    AC A0A378HZJ9.1
#=GS A0A0W0V8D8_9GAMM/302-395    AC A0A0W0V8D8.1
#=GS A0A0W0VEL2_9GAMM/187-287    AC A0A0W0VEL2.1
#=GS A0A222P4T0_9GAMM/218-339    AC A0A222P4T0.1
#=GS A0A0W0XWB3_9GAMM/30-117     AC A0A0W0XWB3.1
#=GS A0A078KZN4_9GAMM/1221-1306  AC A0A078KZN4.1
#=GS A0A0W0VUG5_9GAMM/296-390    AC A0A0W0VUG5.1
#=GS A0A378I153_9GAMM/197-313    AC A0A378I153.1
#=GS A0A222P4V7_9GAMM/297-391    AC A0A222P4V7.1
#=GS A0A3S0WT71_9GAMM/224-318    AC A0A3S0WT71.1
#=GS A0A0W0YVI3_9GAMM/458-546    AC A0A0W0YVI3.1
#=GS Q5ZXT9_LEGPH/416-506        AC Q5ZXT9.1
#=GS W0BCW0_9GAMM/134-242        AC W0BCW0.1
#=GS A0A0W1ANN2_9GAMM/362-455    AC A0A0W1ANN2.1
#=GS A0A0W0TNL6_9GAMM/115-207    AC A0A0W0TNL6.1
#=GS A0A0W0V9L1_9GAMM/297-391    AC A0A0W0V9L1.1
#=GS A0A0W0TNW5_9GAMM/466-558    AC A0A0W0TNW5.1
#=GS A0A222P3D7_9GAMM/2056-2146  AC A0A222P3D7.1
#=GS Q5ZWY9_LEGPH/256-372        AC Q5ZWY9.1
#=GS A0A0W0XVK7_9GAMM/306-401    AC A0A0W0XVK7.1
#=GS A0A0W0XWK4_9GAMM/193-306    AC A0A0W0XWK4.1
A0A0W0R1U1_9GAMM/248-337               .....................ye--PYLKLWNT..K..S..TP.L..................LSARELLNDYTKGN..........SCV...KRFFYGHWN.RHHVAEIAKI..VDQI..DKG.DIR......S...AAD....LMDALN.A.IV....PG.....NPKGS..FARRREFT-e...............
A0A0W0YXC3_LEGSP/316-410               .....................yp--QYDHLWDK..E..L..GL.K..................QNILRVLRDYSKLDc.......rvPAF...SLFATGHWF.RHHHGLVRSA..VTAL..CNG.--D......E...PVE....VIRDLE.A.KA....MDtp.dfNPEGS..LSRRLVFI-s...............
A0A0W1A9D2_9GAMM/505-598               .......................PASYKGIWNA..EgrR..SD.L..................AQAKNLLRDYVKGG..........-FW...GRLFTCHLG.RHHTRAVEQV..LQRN..DLL.NVQ......Q..lVNA....VIAELK.K.TE....GVt...lNPEGS..LARRLDFI-a...............
A0A098G0F2_9GAMM/703-792               .......................PESYDALMTN..C..T..DI.M..................QQVRAILDDYTKGD..........SAF...WRAIFFHWN.RHHTEEVAQI..VTRI..DEG.LIT......N...ISD....VLSELN.L.ID....KS.....NDIGS..LAKRISFM-t...............
A0A0W0ZYV5_9GAMM/51-146                .......................PDTYAKIWNK..I..K..GN.Sn................qRRIKALLIDYTKENcl......fgSFI...GRMISRHWN.RHNVRAVSKI..IANI.sVKN.YYD......S...ADD....IVSDLK.T.LK....-P.....EKGGS..LYQRIKFIE................
W0BH84_9GAMM/296-385                   .......................PASYHQLYQT..S..K..DP.L..................QSARALLNDYTKGN..........SWW...LRFFTGHWN.RHHIQEVAQI..VKKM..DDG.IIK......D...KHS....LLTELN.K.IH....LV.....NINGS..LARRIQFIE................
A0A0W0V896_9GAMM/306-400               .....................qr--AYAHLWSE..S..Q..SS.R..................ENALKVLIDYNKEDw.......riPSL...GLFFTGHWN.RHHHGLVREA..ILNLnvGAN.LSD......T...LKN....LYERAK.T.NE....HF.....NPKGS..LVSRLEYI-l...............
A0A0W0WI89_9GAMM/234-326               .....................pl--SYEKLYQR..G..Q..NS.L..................DSARQLLVDYTKND..........SSF...LRLLHGHWNdRHYVKEVNEL..VKKI..DDM.QIT......T...LDD....LISAFD.N.IQ....AN.....SEHTSdpLFRRIQFIK................
A0A0W0VB83_9GAMM/180-282               .......................PKSYQQIWSR..R..G..DQ.S..................NAVRLLLKDYSKIAhapgffeslaSSA...KLFFAGRWN.RHHHQAVLATftLKNI..NAN.TEE......L...LEA....LKTNLI.A.QG...nTV.....NPEGS..LARRLAFIE................
A0A2Z5V535_9COXI/463-556               ..............pfirfysen----------..-..-..-P.T..................KTCIALLRNYTKGG..........-FF...WRLFTGAWR.RHHIKAVEKF..LKKY..DAQ.QYP......DnlsIQD....IFRELF.N.LNe.gtLAe..ykGKKGT..LFARLLF--ce..............
G9ELB6_9GAMM/715-805                   .............ktartkindv---------K..I..K..DS.I..................AKAAFILNEYTDSN..........SSA...LRFFRGHWN.RHHIKDVSEI..IKKI..DLN.LIS......T...KNE....LKQELN.Q.IK....LV.....NQNGS..FAQCIKLI-n...............
A0A222NYS0_9GAMM/700-789               .......................PESYQTFIKE..G..Q..SL.L..................QQARFLLDDYIKGG..........SWV...QRFFSGHWN.RHHAEEVGKV..VMQI..DKG.LIR......N...TDE....LFAELE.Q.IS....LS.....NEAGS..LARRLSFL-l...............
A0A5N4CE49_CAMDR/42-119                ......rilidtgepaipeyisc----------..-..-..--.-..................-----LKQALTEFN..........TAI...QEIIVTHWH.RDHTGGITDI..CKSI..NNG.KQK......T...LSS....LKKTLD.Q.LY....--.....-----..---------anlelfh.........
A0A433K1E7_9GAMM/23-113                .......................PDSYQAIWKT..P..KaySN.I..................LKIKALLTDYTKENff......lgSFF...GRLFSCHLG.RHHVAKVHEI..I---..-HT.PYE......C...VED....LIYDLK.L.LK....-P.....QKGGS..LDRRLRFIE................
A0A0W0VUD5_9GAMM/1057-1144             ......................l-DSYRRLNPVrgD..K..TP.L..................AKAYEILEDYTKCD..........SRL...LRFFTGHWN.RHHIADVNKI..----..MRA.PPK......N...LET....LLLELQ.K.IK....LV.....NSQGS..LARRITYI-r...............
A0A0W0V9P6_9GAMM/712-803               .........rrvwphsysnfigs----------..-..-..AD.L..................KKAYFILKDYTKQG..........SFF...LRFVHMHWN.RHYSEQISAL..VRKI..ECE.VIT......T...LPQ....LLFELE.Q.MD....IE.....NMGGS..LSRRLAFL-s...............
A0A0W0VBU1_9GAMM/199-312               pprythlwvharmldqairqsep----------..-..-..--.Lk...............dyYSALNLLKDYVKISdnw...pcffSEV...YLLITGHWN.RHHTSSVKKT..LIAV..AKS.PEQ......S...VEI....IIAKLT.E.AL....LEsqesiNPQGS..LARRLLFIQ................
A0A098GJ27_TATMI/306-401               .....................ep--AYKDLWVE..D..D..TV.E..................GNVLRLLIDYSKKNw.......clPSL...GLFFTGHWN.RHHHSIVNEA..IESL..QQG.DR-......T...LKQ....ILDNLE.K.KA....KThp.nfNAEGS..LMCRLDYI-r...............
A0A378I0S3_9GAMM/816-907               ............pssyeikihac---------S..S..Q..NP.L..................DQLKALLIDYTKDD..........SWI...KRFFSGHLN.RHHCKEVTKL..VNKI..DSG.QLN......T...LQE....AVNELH.D.IT....LI.....NPTGS..LARRIQFIK................
A0A378I0I6_9GAMM/311-405               .....................nk--RYQHLWNE..A..N..SF.K..................DNTLAILNDYSKLTy.......psPQF...QLFITGHWA.RHHHVIVKKA..IEQI..EEG.IA-......-...LEH....VLANLR.A.HA....RChp.gfDPKGS..LARRLEFI-d...............
A0A0W0VZY7_9GAMM/300-394               .....................dk--CYSHLWRE..D..N..DA.K..................ANTLAVLIDYNKQDw.......fsPTL...GLFFTGHWN.RHHHQLVRQT..IEDI..KTG.KS-......-...LCL....ALQELR.T.AA....TKhp.nfNIEGS..LIRRCEFI-a...............
A0A0W0V7R3_9GAMM/702-791               .......................PDTYQTLTMD..A..P..SF.M..................HRARLLLDDYTKGG..........SWM...QRFFSGHWN.RHHAEEVGKI..LMQI..DKG.FIT......N...ADE....LFAELE.Q.IP....LS.....NEAGS..LARRLSFL-l...............
G9EKV6_9GAMM/266-355                   ......................r-AFYEKCYEK..N..R..DV.L..................TNARNLLNNYTENN..........SML...MRFFSGHWN.RHHVAAVNKL..VEQI..DKK.QIT......D...IAD....LMKQLK.E.IK....LV.....NPNGS..LARRICFIE................
A0A378LSV2_9GAMM/97-192                .......................PDPYTKIWNN..T..H..GG.Sn................tKRIKALLLDYTKENcv......fgSFI...GRLISGHWN.RHHVQSVSKI..IAKI.sIKN.YYD......S...AED....IVSELK.T.LK....-P.....EKGGS..LYQRIKYIE................
A0A378HZJ9_9GAMM/237-328               ......................p-KSYKEITEK..L..Q..DN.Dna..............tfDQALAILKDYTKSD..........SYLpgaTRFFSGHWN.RHHIDAVDEI..IS--..---.KST......N...LPG....LLDALH.N.IK....LG.....NPTGS..LARRIRFIE................
A0A0W0V8D8_9GAMM/302-395               .....................sr--SYEALWAS..A..D..-L.K..................TNVLKILRDYNKENl.......fgSKL...GLFFTGHWN.RHHQKLVHRA..IASI..ESGeNIQ.....vA...LNN....LLNDAK.N.HP....NF.....NVKGA..LVSRLEYI-s...............
A0A0W0VEL2_9GAMM/187-287               .......................PKSYQQMWKQ..G..S..DP.A..................NAVRVLLKDYSKISggpgffenlaSSA...KLLIAGRWN.RHHHQAVLAT..FENQ..GSD.VED......F...LNA....LRTNLI.A.QG...nTV.....NPEGS..LARRLAFIE................
A0A222P4T0_9GAMM/218-339               .......................PKSYETMWAK..G..R..DE.Kkfsvpv.....dqsfkdyHSAVALLGDYCKSVpyyy..pnffSSL...KLACTGHWN.RHHIDAVKLV..VTEF..THP.QTEpsleemS...VRN....LLSKLQ.D.SL....LAegkplNPNGS..LARRIHFIQ................
A0A0W0XWB3_9GAMM/30-117                .......................PASYYEL--D..K..D..DT.L..................AAARNLLNDYTKSN..........SGL...GRAFTFHWA.RHHTAEINQV..VEDI..DNG.VIQ......D...MDS....LINRLK.S.IE....LV.....NPKGS..LSRRIDLIV................
A0A078KZN4_9GAMM/1221-1306             ....................lkd---YRQVSSY..S..S..FP.L..................LKAQAILKDYTKSD..........SAI...KRFFTGHWN.RHHVDEVSLI..----..LQS.RYK......S...LEE....LLARLS.Q.ID....LL.....NPKGS..LARRIIY--ma..............
A0A0W0VUG5_9GAMM/296-390               ....................qlr---YRHLWNE..H..K..SS.E..................ENILSLLKDYNKEDw.......hfPSL...GLFLTGHWR.RHHHEQIRIA..IRKM..QTG.--T......A...AAE....VLQELD.S.YA....KKhp.qyNPDGS..LARRLEFIQ................
A0A378I153_9GAMM/197-313               .......................PDSYSELWLN..A..K..TQ.Dlfsakgk...erivdsnfSAALALLKDYCKTKapesrfatlfSKV...SLAATLH-K.RHHTNTVRNF..LKDY..SGT.PTV......Na.lLTA....LGDELI.T.AK....NP....iKPTGS..LATRLQFIK................
A0A222P4V7_9GAMM/297-391               .....................ql--HYRHLWSE..E..N..KL.Q..................ENALSLLIDYNKQDw.......qsPSF...GLFITGHWR.RHHYGPVNEA..IHSL..KKG.E--......E...VPV....VLAKLK.EqIQ....HHp..hyNPEGS..LVNRLEFIE................
A0A3S0WT71_9GAMM/224-318               ......................y-AAYAKQWHA..D..R..SP.V..................ENALVLLKDYAKSN..........-WL...ELFFTAHWN.RHHVHLVRDA..LTYF..SKN.PPQ......N...IDEiihhLVNQLA.S.IG....HDk...iNLHGS..LMRRLKFL-s...............
A0A0W0YVI3_9GAMM/458-546               .......................PSSYDRM-SD..Q..T..NS.L..................ANARNILNDYTKNN..........SLF...SRLIHGHWN.RHHVKEVHEI..VKDI..DAK.NIK......N...MDE....LVMRLS.A.IH....LE.....NPKGS..LARRMEFIV................
Q5ZXT9_LEGPH/416-506                   .......................PDSYKRIWDS..A..D..GD.Sn................iTKIKALLKDYTKEDsi......lgSFW...GLIFTLHWG.RHHVKSVHQI..----..AQT.KYT......S...VEA....ILSDLK.A.LK....-P.....REGGS..LDKRIKFIE................
W0BCW0_9GAMM/134-242                   .....................pk--AWDKLLTS..E..Q..SE.Lna..............lkEQCAKLLADYA---..........SGV...GNFFKLHWN.RHHTGPAKEL..LHAI.rEQK.DIA......G...IAN....LLAREY.R.HQ....AEkp.dfNPVGS..YARRLK---tllceanksldekicl
A0A0W1ANN2_9GAMM/362-455               .....................pp--DYEKLWNE..T..K..GSdV..................QKAIRLLQDYTKEN..........NNS...MMFFTGHWN.RHHTDLIKKA..LYEF..KNN.PPQ......S...LKE....IIGYFKkN.ID....INk...lNTAGS..LMKRLDFI-a...............
A0A0W0TNL6_9GAMM/115-207               .....................lk--SYYIQWTK..G..K..SN.L..................ESSIKLLEDYANGNs.......vgSYL...KL-RFFRDG.SKDLTLVKEI..IQKA..KEC.KIE......T...VEE....LIASFT.E.KE...dIH.....HFDGG..LQRRLKFI-s...............
A0A0W0V9L1_9GAMM/297-391               .....................hi--RYKHLWQD..G..N..SF.E..................ENVLSLLIDYNKQNw.......qyPSL...GLFLTGHWN.RHHQERIREA..IQEL..QDGkNVH.....lV...IKE....LKDYID.S.IN....EV.....NPDGS..LAMRLAYM-h...............
A0A0W0TNW5_9GAMM/466-558               .......................PQSYDALWHD..R..DcrTE.L..................ARIRNLLQDYVKGG..........-FW...GRLLHFHLG.RNHTSAVAIV..LNDK.sVVS.SQG......L...LNA....LVRELD.G.RG...aSL.....NPTGS..LMRRLEFIK................
A0A222P3D7_9GAMM/2056-2146             .......................PASYTKICES..H..T..DP.L..................AKARALLDDYTKSN..........LSV...SRLFHGHWR.RHHVVELSLI..IEEI.gRDK.AIN......N...IKD....LLHLLS.C.IP....LQ.....NSKGS..LAHRIGFIK................
Q5ZWY9_LEGPH/256-372                   ......................f-AAYHELWRN..A..F..QE.ImndprhqlhrndveykkiHAIRTVLDDYTKGGnt......wwAKF...RRIFTFHWN.RHHVKVVDDI..VKEI..DAG.NYT......T...SRA....LVDRLD.N.LA....ISlgsklNPKGT..LKEQIGFIK................
A0A0W0XVK7_9GAMM/306-401               ....................kgd---YTHLWSL..Q..E..TT.P.................kQNALKILIDYSKMDs.......tyPAL...VRFFTAHTQ.RHHHPLVKVA..VDAL..VQG.--E......N...IHS....VMMTLE.T.EArkhpFF.....NEEGS..LMRRLRFI-t...............
A0A0W0XWK4_9GAMM/193-306               .......................PHSYERLWQT..G..A..GP.Sdkles........evsdfRAALEILRDYSKSNnpdt.csffgSTV...KLAFTRHLL.RHHTDVVDEL..YKQY..YNK.DHA......T...AGD....LINELK.E.KL....ISqgdklNRTGS..LAQRIRFIE................
#=GC seq_cons                          .........................sYpplapp..t..p..ss.h..................ppshsLLpDYoKps..........Sth...thhFoGHWN.RHHhptVpcl..lppl..sps..hp......s...lps....LlscLc.s.ht....hs.....NspGS..LuRRlpFI.................
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