#=GF ID   DUF5743
#=GF AC   PF19014.4
#=GF DE   Family of unknown function (DUF5743)
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   Jackhmmer:W6URS5
#=GF GA   25.00 25.00;
#=GF TC   30.80 51.00;
#=GF NC   24.50 21.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR044041;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   A highly conserved domain of unknown function found in various
#=GF CC   Platyhelminthes.
#=GF SQ   42
#=GS A0A8E0VFU6_9TREM/87-272   AC A0A8E0VFU6.1
#=GS A0A4E0R7L7_FASHE/111-292  AC A0A4E0R7L7.1
#=GS A0A4S2LE63_OPIFE/1-87     AC A0A4S2LE63.1
#=GS A0A0X3P542_SCHSO/87-272   AC A0A0X3P542.1
#=GS A0A0R3U865_MESCO/137-319  AC A0A0R3U865.1
#=GS A0A8J4SRT6_9TREM/113-295  AC A0A8J4SRT6.1
#=GS A0A3S5ATN1_9PLAT/50-246   AC A0A3S5ATN1.1
#=GS A0A504YKT3_FASGI/1-87     AC A0A504YKT3.1
#=GS A0A183ACA6_9TREM/88-274   AC A0A183ACA6.1
#=GS A0A3S4ZXY4_9PLAT/43-137   AC A0A3S4ZXY4.1
#=GS H2KPG2_CLOSI/87-271       AC H2KPG2.1
#=GS A0A654HHD5_9CEST/1-84     AC A0A654HHD5.1
#=GS A0A0R3U7M0_MESCO/87-272   AC A0A0R3U7M0.1
#=GS A0A3P6RCL8_DIBLA/1-84     AC A0A3P6RCL8.1
#=GS A0A7M3RSR7_SPIER/111-296  AC A0A7M3RSR7.1
#=GS H2KR65_CLOSI/120-292      AC H2KR65.1
#=GS A0A3P7M6T7_DIBLA/87-272   AC A0A3P7M6T7.1
#=GS A0A8E0RQ42_9TREM/110-292  AC A0A8E0RQ42.1
#=GS A0A0R3X0Z8_HYDTA/87-273   AC A0A0R3X0Z8.1
#=GS A0A075AFI7_9TREM/119-292  AC A0A075AFI7.1
#=GS A0A8J4TMC7_9TREM/87-275   AC A0A8J4TMC7.1
#=GS A0A183VY37_TRIRE/1-87     AC A0A183VY37.1
#=GS A0A2H1CTU2_FASHE/88-274   AC A0A2H1CTU2.1
#=GS A0A0R3W3D8_TAEAS/87-273   AC A0A0R3W3D8.1
#=GS A0A183AIJ5_9TREM/1-79     AC A0A183AIJ5.1
#=GS A0A5J4N8Q9_9TREM/87-275   AC A0A5J4N8Q9.1
#=GS A0A074Z338_9TREM/87-271   AC A0A074Z338.1
#=GS A0A504Z9S1_FASGI/110-209  AC A0A504Z9S1.1
#=GS A0A4S2LKS5_OPIFE/120-292  AC A0A4S2LKS5.1
#=GS A0A7M3RSQ3_SPIER/87-272   AC A0A7M3RSQ3.1
#=GS A0A654GKD7_9CEST/87-272   AC A0A654GKD7.1
#=GS A0A183WJM2_TRIRE/87-274   AC A0A183WJM2.1
#=GS A0A183AIJ4_9TREM/111-216  AC A0A183AIJ4.1
#=GS A0A504Z4S6_FASGI/88-274   AC A0A504Z4S6.1
#=GS W6URS5_ECHGR/87-273       AC W6URS5.1
#=GS A0A4S2LDT5_OPIFE/87-271   AC A0A4S2LDT5.1
#=GS A0A654HGU6_9CEST/111-219  AC A0A654HGU6.1
#=GS A0A3P7N3I0_DIBLA/96-200   AC A0A3P7N3I0.1
#=GS A0A074YZR9_9TREM/87-271   AC A0A074YZR9.1
#=GS A0A183WBW2_TRIRE/111-215  AC A0A183WBW2.1
#=GS A0A183TDX7_SCHSO/108-293  AC A0A183TDX7.1
#=GS A0A5J4P1Y9_9TREM/114-295  AC A0A5J4P1Y9.1
A0A8E0VFU6_9TREM/87-272              ..................................RHNELLADHLASLGFASLE.S---GGSVRHLALCRSPGLRKSMLQQRGGGA.--VTA......AN....EPRPPTHMIDNIALAIAeiHQEVRAKVKPLLDYYRDLFYLQLHFSLVLGQVCNYCMPLVTENIGLIDRIFFWSERPe.fdLVRRAGDIGDRLKEIYTRAQTVLSVLAESVRFLQSKVELQKTLEQRFHERLDEQQ......
A0A4E0R7L7_FASHE/111-292             .....................vgvvsrldgsdpn-------------------.-RSGTGTAVLSSAIPPPVSAPDSVDAALHGG.LDNFA......GK....VDVDMLQVPEEIDLANT..TTETGAHLLPVVDFYRSLYFLQMHFQLIMCQAANYAMPVVTRSMSLAERAFSWPTMPs.fgLATNSGSMKDRLLEINTEVVQIAHRLLGCLALVRDKIARDKVIESYFFQHTAAQE......
A0A4S2LE63_OPIFE/1-87                ..................................-------------------.-------------------------------.-----......--....-----------------..----------------------------MCQAANYAMPVVTRPMSLSERTFSWPTMPs.fgLAATSGSMRDRLLEIHTDVTMLAKRLHECLRLVREKMAQDRKIESYFMQHTNAQE......
A0A0X3P542_SCHSO/87-272              ..................................RHNELLADQLASQGLGALE.T---GGTARHMALIRSPNIKKQMMAQRKNAL.-DPCA......-N....GGKSQTHLIDNIALAIDeiHQEVRTKVKPLLDYYRDLFYLQLHFSLVLGQVCNYCMPLVTENIGLLERVFFWAERPe.feLIRKASDISDRLKEIYTRSQQIYGVLSESVRFLQSKVELQKSLETRFHERMDEQQ......
A0A0R3U865_MESCO/137-319             ..................................RDADVVVDRK-NYLSDRFQ.ASSRRLHPGGNSEVVEHQSRAS-LEEDLMGE.FGVKG......AD...eVNIDQLDVPPEVDLSCD..TDETGQALLPLMEFYRRFYFQQINFQQAMCMTAHRSMPLITQCPGLGRRIRGWRMEK....--KKRTGIVDHLEDIRADLTCLIDRLDRCVDRVKAKIRQDEAIDSCYRQHCAAQE......
A0A8J4SRT6_9TREM/113-295             ........ivtrigqdqqpdpnrsgtgtavlgns-------------------.------------LPPPINA-PDSVEQALHGG.LDRFK......GT....IDVDVLQVPEEIDLATT..TTESGTHLLPVVEFYRGFFFLQMHFQLIMCQAANYAMPVVTRPMSLAERAFSWPTMPs.fgLASTTGALKDRLLDIHTDVVALATRLHECLALVREKMLQDRKIESYFMQHTAAQE......
A0A3S5ATN1_9PLAT/50-246              ..................................RHNELLADHLASLGYGSLE.T---GGSARHAALVRSPQMRKAMLAQRQGAS.-DLVGltggagAGcvgeEARFGSKMIDNIALAIAeiHREVRLKVKPLLEYYRDLFYLQLHFSLILGQVCNYCMPLVTENIGLIDRIFFWSERPe.fdLVRRSGDISDRLKEVYTRGQAVLSVLTESVRFLKSKVDLQKSLEARFRERLDEQQ......
A0A504YKT3_FASGI/1-87                ..................................-------------------.-------------------------------.-----......--....-----------------..----------------------------MCQAANYAMPVVTRSMSLAERAFSWPTMPs.fgLATNSGSMKDRLLEINTEVVQIAHRLLSCLALVRDKIARDKVIESYFFQHTAAQE......
A0A183ACA6_9TREM/88-274              ..................................RHNELLADHLASLGFASLE.S---GASVRHLALCRSPQMRKNMIAQRQGGA.-GSSS......MS....EPRPPTHMIDNIALAISeiHQEVRAKVKPLLDYYRDLFYLQLHFSLVLGQVCNYCMPLVTENIGLIDRIFFWSERPe.fdLVRRAGDIGDRLKEIYTRAQTVLSVLAESVRFLQSKVELQKTLEQRFHERLDEQQ......
A0A3S4ZXY4_9PLAT/43-137              .............................lsyrr-------------------.-------------------------------.-----......--....-----------------..--------------------------IILCQAVNFALPVLTRPLSLAERTIGWPSKPmygfLTGPTGRMSDQLRRLHMEVTRLASQLEQCASLVGAKLRQDGRIEAYYRRYQAA--hk....
H2KPG2_CLOSI/87-271                  ..................................RHNELLADHLAGLGFGSLE.T---GGSARHMALVRSPQMRKNLLAQRGAGA.-GGI-......-S....ETRPPTHMIDNIALAMAeiHQEVRSKVKPLLDYYRDLFYLQLHFSLVLGQVCNYCMPLVTENIGLIDRIFFWSERPe.fdLVRRAGDIGDRLKEIYTRAQTVLGVLAESVRFLQSKVELQKTLEQRFHERLDEQQ......
A0A654HHD5_9CEST/1-84                ..................................-------------------.-------------------------------.-----......--....-----------------..----------------------------MCLVANYSMPFVTNPVSLGKRIRGWPKEP....LKGKHESIGERLRGIQGELTVLLRRLEECLDLVQEKMIQDKIIENYYRMHVHAQE......
A0A0R3U7M0_MESCO/87-272              ..................................RHNEILAEQLVRQGLSGSD.R---VPSARHLALVRSPQTRKLMLSQRRSSA.-ERYG......G-....EGRSQVHLLDNIALAIDeiHSEVRNKVKPLLDYYRDLFYLQLHFSIVLGQVCNYCMPLVTENIGLLERVFFWAERPe.feLIRKASDISDRLKEIYTRAQQIYGFLTESVRFLQSKVDLQKSLETRFRERTDEQQ......
A0A3P6RCL8_DIBLA/1-84                ..................................-------------------.-------------------------------.-----......--....-----------------..----------------------------MCLVANYSMPFVTNPVSLGRRIRGWPREP....LRGKHETIGERLRGIRGEMSILLKRLEECLDLVQEKMFQDKIIENYYRMHVHAQE......
A0A7M3RSR7_SPIER/111-296             .................................l-QAARATRVLLGTSIPSHK.VKRKKGVVVQCDGPPSLVPISAGIETALHGG.LEPHA......GD....INVDRIRVPPEVDLSLA..CTPSGQPLLPVVEFYRGFFFLQMHFQVTMCLVANYSMPFVTNPVSLGKRIRGWPKEP....LKGKNESIGERLRSIQGELTVLLRRLEECLDLVQEKMIQDKIIENYYRMHVHAQE......
H2KR65_CLOSI/120-292                 ..........gdpnrsgtgtavlgpalpppinap-------------------.---------------------DSVEQALHGG.LTHHK......FN....VDVDHLDIPPEVDLATA..TTDSGTHLLPVVDFYRGFFFLQMHFQLIMCQAANYAMPVVTRPMSLSERTFSWPTMPs.fgLAATSGSMKDRLLEIHTDVTVLAKRLHECLRLVREKMTQDRKIESYFMQHTNAQE......
A0A3P7M6T7_DIBLA/87-272              ..................................RHNELLADQLASQGLGALE.T---GGTARHMALIRSPNIKKQMMAQRKSAL.-DPCA......-N....GGKSQTHLIDNIALAIDeiHQEVRTKVKPLLDYYRDLFYLQLHFSLVLGQVCNYCMPLVTENIGLLERVFFWAERPe.feLIRKASDISDRLKEIYTRSQQIYGVLSESVRFLQSKVELQKSLETRFHERMDEQQ......
A0A8E0RQ42_9TREM/110-292             ..........................gagvvsrl---------------DGSEtNRSGTGTAVLTSAIPPPISAPDPIDAALHGG.LDNFG......GK....VDVDSLQVPEEINLATS..TTDTGAHLLPVVDFYRSLYFLQMHFQLIMCQAANYAMPVVTRSMTLTERAFSWPTMPs.fgLAANSGSMKDRLLEINTEVIQLAQRLLGCLGLVREKIARDKVIESYFFQHSAAQE......
A0A0R3X0Z8_HYDTA/87-273              ..................................KHNEILAQQLVNYGFDGLE.S---NLTARQLAMIRAPQTRKQMLIQRRTSS.-DMCA......GD....GERSKSHLIDNIALALDeiHKEVRNKVKPLLDYYRDLFYLQLHFSIVLGEVCNYCMPIVTENIGLLERVFFWSDRPe.feLIRKSSDISDRLKEIYTRTQQIYHILSESVRFLQSKVDLQKSLEARFHERNDEQQ......
A0A075AFI7_9TREM/119-292             .........dgdpnrsgtgtavigpslpppinap-------------------.---------------------DSVEQALHGG.LTHHK......FN....VDVDNLDIPPEVDLATA..TTDSGTHLLPVVDFYRGFFFLQMHFQLIMCQAANYAMPVVTRPMSLSERTFSWPTMPs.fgLAATSGSMKDRLLEIHTDVTVLAKRLQECLRLVREKMAQDQKIESYFMQHTNAQE......
A0A8J4TMC7_9TREM/87-275              ..................................RHNELLADHLASLGYASLE.S---GASVRHLALCRSPQMRKSMLAQRQGGGgLGCSR......LT....EPRPPTHMIDNIALAIAeiHQEVRAKVKPLLDYYRDLFYLQLHFSLVLGQVCNYCMPLVTENIGLIDRIFFWSERPe.fdLVRRAGDIGDRLKEIYTRAQTVLGVLAESVRFLQSKVELQKTLEQRFHERLDEQQ......
A0A183VY37_TRIRE/1-87                ..................................-------------------.-------------------------------.-----......--....-----------------..----------------------------MCQAANYAMPVVTRTMSLAERTFAWPSIPg.fgLKAKNGTMRDRLLEIHTDVIQLAQRLHACMELVNDKIAQDKRIEQYYLQHSSAQE......
A0A2H1CTU2_FASHE/88-274              ..................................RHNELLADHLASLGCASLE.S---GGSVRHLALCRSPQMRKNMLAQRQGSG.-ALST......AS....ESRPPTHMIDNIALAIAeiHQEVRSKVKPLLDYYRDLFYLQLHFSLVLGQVCNYCMPLVTENIGLIDRIFFWSERPe.fdLVRRAGDIGDRLKEIYTRAQTVLSVLAESVRFLQSKVELQKTLEQRFHERLDEQQ......
A0A0R3W3D8_TAEAS/87-273              ..................................KHNEILAQQLVNYGFDGVE.N---NLTARQIAMVRAPQTRKQMLVQRRSGS.-DMCA......GD....GGRSKTYLIDNIALALDeiHKEVRNKVKPLLDYYRDLFYLQLHFSIVLGQVCNYCMPIVTENIGLIERVFFWSERPe.feLIRKASDISDRLKEIYTRTQQIYHILSESVRFLQSKVDLQKSLEARFHERSDEQQ......
A0A183AIJ5_9TREM/1-79                ..................................-------------------.-------------------------------.-----......--....-----------------..------------------------------------MPVVTRSMSLAERAFSWPTMPs.fgFAANSGSMKDRLLEINTEVLQLAHRLLGCLALVREKIAQDRKIESYFFQHTAAQE......
A0A5J4N8Q9_9TREM/87-275              ..................................RHNELLADHLASLGYSSLE.S---GASVRHLALCRSPQMRKSMLAQRQGGG.-GLGS......SRl..tEPRPPTHMIDNIALAIAeiHQEVRAKVKPLLDYYRDLFYLQLHFSLVLGQVCNYCMPLVTENIGLIDRIFFWSERPe.fdLVRRAGDIGDRLKEIYTRAQTVLGVLAESVRFLQSKVDLQKTLEQRFHERLDEQQ......
A0A074Z338_9TREM/87-271              ..................................RHNELLADHLAGLGFGSLE.T---GGSARHMALVRSPQMRKNMLAQRGAGA.-G--G......VS....ETRPPTHMIDNIALAMAeiHQEVRSKVKPLLDYYRDLFYLQLHFSLVLGQVCNYCMPLVTENIGLIDRIFFWSERPe.fdLVRRAGDIGDRLKEIYTRAQTVLGVLAESVRFLQSKVELQKTLEQRFHERLDEQQ......
A0A504Z9S1_FASGI/110-209             .....................gvgvvsrldgsdp-------------------.NRSGTGTAVLSSAIPPPVSAPDSVDAALHGG.LDNFA......GK....VDVDMLQVPEEIDLANT..TTETGAHLLPVVDFYRSLYFLQMHFQVSLK---------------------------....-------------------------------------------------------qy....
A0A4S2LKS5_OPIFE/120-292             ..........gdpnrsgtgtavlgpalpppinap-------------------.---------------------DSVEQALHGG.LTHHK......FN....VDVDNLDIPPELDLATA..TTDSGTHLLPVVDFYRGFFFLQMHFQLIMCQAANYAMPVVTRPMSLSERTFSWPTMPs.fgLAATSGSMRDRLLEIHTDVTMLAKRLHECLRLVREKMAQDRKIESYFMQHTNAQE......
A0A7M3RSQ3_SPIER/87-272              ..................................RHNELLADQLASQGLGALE.T---GGTARHMALIRSPNIKKQMMAQRKNAL.-DPCA......-N....GGKSQTHLIDNIALAIDeiHQEVRTKVKPLLDYYRDLFYLQLHFSLVLGQVCNYCMPLVTENIGLLERVFFWAERPe.feLIRKASDISDRLKEIYTRSQQIYGVLSESVRFLQSKVELQKSLETRFHERMDEQQ......
A0A654GKD7_9CEST/87-272              ..................................RHNELLADQLASQGLGSLE.T---GGTARHMALIRSPNIKKQMMAQRKNAL.-DPCA......-N....GGKSQTHLIDNIALAIDeiHQEVRTKVKPLLDYYRDLFYLQLHFSLVLGQVCNYCMPLVTENIGLLERVFFWAERPe.feLIRKASDISDRLKEIYTRSQQIYGVLSESVRFLQSKVELQKSLETRFHERMDEQQ......
A0A183WJM2_TRIRE/87-274              ..................................RHNELLADQLASLGYASLE.S---GASVRHLALCRSPQMRKNMLAQRQGGS.LGFQK......YS....EPRPPTHMIDNIALAIAeiHQEVRAKVKPLLDYYRDLFYLQLHFSLVLGQVCNYCMPLVTENIGLIDRIFFWSERPe.fdLVRRAGDIGDRLKEIYTRAQTVLGVLAESVRFLQSKVELQKTLEQRFHERLDEQQ......
A0A183AIJ4_9TREM/111-216             ....................vgmvtrlgqdedsd------------------I.NRSGTGTAVLGNAIPPPVSAPDSVEAALHGG.LDNCI......GK....VNVDILDIPEEIDLATT..TTESGAHLLPVVDFYRGFYFLQMHFQVSLSL--------------------------....-------------------------------------------------------edfkc.
A0A504Z4S6_FASGI/88-274              ..................................RHNELLADHLASLGCASLE.S---GGSVRHLALCRSPQMRKNMLAQRQGSA.-ALST......AS....ESRPPTHMIDNIALAIAeiHQEVRSKVKPLLDYYRDLFYLQLHFSLVLGQVCNYCMPLVTENIGLIDRIFFWSERPe.fdLVRRAGDIGDRLKEIYTRAQTVLSVLAESVRFLQSKVELQKTLEQRFHERLDEQQ......
W6URS5_ECHGR/87-273                  ..................................KHNANLAQQLVNHGFNGVE.N---NLTARQLAMVRAPQTRKQMLVQRRASS.-DMCA......GD....GGRSKVHLIDNIALALDeiHKEVRNKVKPLLDYYRDLFYLQLHFSIVLGQVCNYCMPIVTENIGLLERVFFWSERPe.feLLRKASDISDRLKEIYTRTQQIYHILSESVRFLQSKVDLQKSLETRFHERTDEQQ......
A0A4S2LDT5_OPIFE/87-271              ..................................RHNELLADHLAGLGFGSLE.T---GGSARHMALVRSPQMRKNMLAQRGAGA.---SG......IS....ETRPPTHMIDNIALAMAeiHQEVRSKVKPLLDYYRDLFYLQLHFSLVLGQVCNYCMPLVTENIGLIDRIFFWSERPe.fdLVRRAGDIGDRLKEIYTRAQTVLGVLAESVRFLQSKVELQKTLEQRFHERLDEQQ......
A0A654HGU6_9CEST/111-219             .................................l-QAARASRVLLGTSIPSHK.VKRKKGVVVQCDGPPSLVPISAGIETALHGG.LEPHA......GE....INVDRIRVPPEVDLSLA..CTPSGQPLLPVVEFYRGFFFLQMHFQVSI----------------------------....-------------------------------------------------------rsllta
A0A3P7N3I0_DIBLA/96-200              .................................l-QAARATRVLRGTAIPSHK.LKRKKGVVVNCDGPPSLMPISAGIETALHGG.LEPPT......GS....VNVDRLNVPPEVDLSVA..YTPSGQPLMPVVEFYRGFFFLQMHFQVS-----------------------------....-------------------------------------------------------csw...
A0A074YZR9_9TREM/87-271              ..................................RHNELLADHLAGLGFGSLE.T---GGSARHMALVRSPQMRKNMLAQRGAGA.-G--G......VS....ETRPPTHMIDNIALAMAeiHQEVRSKVKPLLDYYRDLFYLQLHFSLVLGQVCNYCMPLVTENIGLIDRIFFWSERPe.fdLVRRAGDIGDRLKEIYTRAQTVLGVLAESVRFLQSKVELQKTLEQRFHERLDEQQ......
A0A183WBW2_TRIRE/111-215             knqgtgqsnegimsnsggsstnvtvvdrilpppi-------------------.------------------SAPDAVSAALHGG.LDQFT......FK...dINVDCLQVPEEIDLATC..TTEGGSPLLPVVEFYRGFYFLQMHFQVS-----------------------------....-------------------------------------------------------nvlkq.
A0A183TDX7_SCHSO/108-293             .................................l-QAVRATRVLLGTAIPSHK.VKRKKGVVVQCEGPPSLMPISAGIETALHGG.LEPHS......GG....VNVDRLHVPPEVDLSVA..FTPSGQPLLPVVEFYRGFFFLQMHFQVTMCLVANYSMPFVTNPVSLGKRIRGWPREP....LKGKNESIGERLKNIQSELTVLLKRLEECLDLVQEKIIQDKIIENYYRTHVHAQE......
A0A5J4P1Y9_9TREM/114-295             .aarigqdqqsdpnrcgtgtavlgsplpppinap-------------------.---------------------DSVEQALHGG.LDRFK......GT....IDVDVLQVPEEVDLATT..TTESGTNLLPVVEFYRGFFFLQMHFQLIMCQAANYAMPVVTRPMSLAERAFSWPTMPs.fgLASTTGAMKDRLLDIHTDVMTLATRLRECLALVREKMLQDRKIESYFIQHTAAQE......
#=GC seq_cons                        .................................................st.p.s...thssh.hsh..s...t.s.ltpthtuu..s.hs......hs.....shs.hch.-pIsLAhs..ppEsts+lhPllDaYRshFaLQhHFpllhsQssNYsMPlVTcshuLh-RhFhWspcPp.FtLht+uuslsDRLcEIaTcspplhthLtEslchlppKlt.pKplEphF+p+hstQp......
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