#=GF ID   DUF5746
#=GF AC   PF19017.4
#=GF DE   Domain of unknown function (DUF5746)
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   Jackhmmer:U6J0P5
#=GF GA   23.60 23.60;
#=GF TC   23.60 23.70;
#=GF NC   23.50 23.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Domain_of_unknown_function
#=GF CL   CL0117
#=GF DR   INTERPRO; IPR043955;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is a highly conserved domain found in various
#=GF CC   Platyhelminthes. Its function is currently unknown, with some of
#=GF CC   the sequences annotated as being Palmitoyltransferase. This
#=GF CC   highly conserved domain is located at the amino terminus, next
#=GF CC   to a DHHC domain (named for its signature tetrapeptide
#=GF CC   Asp-His-His-Cys).
#=GF SQ   29
#=GS G4VGB5_SCHMA/46-234       AC G4VGB5.1
#=GS A0A8J4TM83_9TREM/12-197   AC A0A8J4TM83.1
#=GS A0A430QR14_SCHBO/4-191    AC A0A430QR14.1
#=GS A0A0R3SH38_HYMDI/58-240   AC A0A0R3SH38.1
#=GS A0A267H5U3_9PLAT/41-145   AC A0A267H5U3.1
#=GS A0A267EIL0_9PLAT/32-136   AC A0A267EIL0.1
#=GS A0A0R3TYK6_RODNA/58-240   AC A0A0R3TYK6.1
#=GS A0A267EXT4_9PLAT/49-149   AC A0A267EXT4.1
#=GS A0A267FSI8_9PLAT/49-149   AC A0A267FSI8.1
#=GS G7YPD6_CLOSI/15-196       AC G7YPD6.1
#=GS A0A183TLI0_SCHSO/33-214   AC A0A183TLI0.1
#=GS A0A183AEX9_9TREM/30-219   AC A0A183AEX9.1
#=GS A0A183KE60_9TREM/2-111    AC A0A183KE60.1
#=GS A0A0R3U6H6_MESCO/56-237   AC A0A0R3U6H6.1
#=GS A0A4E0S3Y6_FASHE/25-213   AC A0A4E0S3Y6.1
#=GS A0A3P7L7Y5_DIBLA/69-250   AC A0A3P7L7Y5.1
#=GS A0A0R3W3J8_TAEAS/92-274   AC A0A0R3W3J8.1
#=GS A0A0R3X565_HYDTA/58-240   AC A0A0R3X565.1
#=GS A0A183PUZ2_9TREM/62-141   AC A0A183PUZ2.1
#=GS A0A183PUZ2_9TREM/138-194  AC A0A183PUZ2.1
#=GS A0A267FSI8_9PLAT/9-52     AC A0A267FSI8.1
#=GS A0A4Z2CM70_SCHJA/18-209   AC A0A4Z2CM70.1
#=GS U6J0P5_ECHGR/56-238       AC U6J0P5.1
#=GS A0A0R3T6K1_RODNA/32-214   AC A0A0R3T6K1.1
#=GS A0A183MMH8_9TREM/66-253   AC A0A183MMH8.1
#=GS A0A654HGC6_9CEST/92-265   AC A0A654HGC6.1
#=GS A0A267EXT4_9PLAT/9-52     AC A0A267EXT4.1
#=GS A0A8E0VMY6_9TREM/1-172    AC A0A8E0VMY6.1
#=GS A0A5J4P2I1_9TREM/73-251   AC A0A5J4P2I1.1
G4VGB5_SCHMA/46-234                  ................kh--AYSICCWLVVIIFV.......A.......IAYLTKTNYLKHS.NN...........PIVkq....tqhCYVCDNYASLSESSGFRPGPGTGLaWFGGKPVVGGWTSMSSNgnqlrggLTSLQISRLCSERVNRSAIKLLIDSENYGkCENINYDGCAKIVTKSWRV...RSQLGV...PSLSAVVVSRTCA.A.IPEG...YGVGCFNSVGGAGMRRTICYCRG.NFCN.....
A0A8J4TM83_9TREM/12-197              .............tvyac-------CAAFVVLTVaslfgyyQ.......SAYLTNSAGQPVS.RL...........PTR.........CYTCDNYASVETGV--RPGVGSGLaWLDGKPVQGGWSKLSSHgvn.sngLTAVQASRLCSERVNRTRMRRLIDSQDYGeCPNANYDGCVKLVTKSYRV...KAQIGV...PVLSAVVVSRTCA.I.IPEA...MGVGCFDSVGGAGMRRTICYCRG.NFCN.....
A0A430QR14_SCHBO/4-191               ................kg--VYSICCWLVVIIFI.......T.......IAYVTKTNYLKYS.NK...........SIVkq....tqhCFVCDNYASLSDSSGFRPGPGTGLaWFGGKPVVGGWTSMSSNgnhlrngLTSLQISRLCSERVNRSAIKLLIDSENYGkCENINYNGCAKIVTKSWRV...RPQLGV...PTLTAVVVSRTCA.A.IPEG...YGVGCFNSVGGAGMRRTICYCRD.P---si...
A0A0R3SH38_HYMDI/58-240              .................t-VIISLAVITCVIFTV.......M.......WINWARSHSGYVW.GDegpl..gpeqpPAV.........CYKCSNYAHIMDGRELNSKIDVEQ.DEAGGVEIGGALGIAVE.......IGDPRQ-ELCQEFVNRTALAETQAPSDDD.CGDSLYNGCFKMVTKTYRM...TSNIGR...EQLSVTIVTRNCV.E.IPKS...ISLGCYKTFGGAGMERETCYCKG.NYCN.....
A0A267H5U3_9PLAT/41-145              .................l----------------.......-.......-------------.--...........---.........------------------------.---------------RN.......LDTTSKSEILKRYCGIEARITDSNQAD--.CGGADYDGCVKIVTRSYRYhidREGVGMrapETLISTVVTRDCA.E.IPKA...MGVGCHMLY-GAGSTTEMCYCKG.DYCN.....
A0A267EIL0_9PLAT/32-136              .................l----------------.......-.......-------------.--...........---.........------------------------.---------------RN.......LDTTSKSEILKRYCGIEARITDSNQAD--.CGGADYDGCVKIVTRSYRYhidREGVGMrapETLISTVVTRDCA.E.IPKA...MGVGCHMLY-GAGSTTEMCYCKG.DYCN.....
A0A0R3TYK6_RODNA/58-240              .................v-VLISLACIICIIFIV.......I.......WINWTRSRSGNVW.GDegpl..gpeqpPAV.........CYKCSNYAHIMDGRELNSNIDIER.GEGGGAEVGGALGIAVE.......IEGPRQ-ELCQEVVNRTALAETQVLSNDD.CGDSLYNGCFKMITKTYRM...TSNIGH...ELLSVTIVTRNCV.E.IPKG...FPLGCYKTFGGGGMERETCYCKG.NYCN.....
A0A267EXT4_9PLAT/49-149              .................r----------------.......-.......-------------.--...........---.........------------------------.-----------------.......--NSKDASLAERFCNASLSLTGNRHTK--.CRNRDLNGCVKMTTKAWRYhidKQGGGMreaATLIATVVTRDCA.E.IPPG...MGTGCHTMY-GAGTTKEICYCVG.PGCN.....
A0A267FSI8_9PLAT/49-149              .................r----------------.......-.......-------------.--...........---.........------------------------.-----------------.......--NSKDASLAERFCNASLSLTGNRHTK--.CRNRDLNGCVKMTTKAWRYhidKQGGGMreaATLIATVVTRDCA.E.IPPG...MGTGCHTMY-GAGTTKEICYCVG.PGCN.....
G7YPD6_CLOSI/15-196                  ..............lsvi----AIAACCSLLFAI.......L.......QISWTGSAHNNHSpST...........RAR.........CYICDNYASVEPGASISAASGL-A.WLGGKPIAGGWSESGSAgtn.qngLSATQAARLCTERVNRSRIRALIGSHDYGeCPNKSYDGCAKIVTKSYRV...KAQIGY...PVLSAVVVTRTCA.V.VPSG...MGVGCFRSAGGAGMRRTICYCRG.DFCN.....
A0A183TLI0_SCHSO/33-214              .................t-RRPWLPVYLLLVVFL.......G.......SCAFTTLRQSR--.-DrippilpdpmqPAT.........CYRCDNYLNLMVGKNINAQKDVEMtGQFGGS-VVGAGGIASE.......LSKPEDVDLCAEYVNRSALVSLQ--SDGDfCEEHRFNGCFKMITKSYRV...TAGLGR...EQLVVTVVTRNCA.E.IPET...ISLGCQKIYGGAGMVRELCYCKG.DYCN.....
A0A183AEX9_9TREM/30-219              ............frwtqc------AVWTTVLSLL.......T.......ATFVGLCGLATFH.EK...........PRVirstkeelrCYTCDNYASVGSGG--RPGAASGLaWMGGKPVLTGQTAQSNTgsm.nggMNAIQASRLCAEKVNRTAMRALITSKSYGlCSGVAFDGCAKIVTKSYRI...KPQAGT...LILSAVVVSRTCA.H.IPEG...LGIGCFDTVGGAEIRQRICYCRG.PFCN.....
A0A183KE60_9TREM/2-111               ..........ssngnhlr----------------.......-.......-------------.--...........---.........------------------------.---------------NG.......LTSLQISRLCSERVNRSAIKLLIDSANYGkCENINYNGCAKIVTKSWRV...RPQLGV...PTLTAVVVSRTCA.A.IPEG...YGVGCFNSVGGAGMRRTICYCRG.NFCN.....
A0A0R3U6H6_MESCO/56-237              ................av--ALSLVLIICFIGIA.......I.......WVAWTRSSSLQST.DEgpqg...pelpPAI.........CYKCNNYAHVMDGREVNSNVDVER.AEGGAAEVAGALGVAVN.......VGDPRR-ELCQEFVNRTALAETQSPADDD.CGDSLYNGCFKMTTKSYRL...TANVGR...EQLSVTIVTRNCV.E.IPRS...IPLGCYKTFGGAGMERETCYCKG.NYCN.....
A0A4E0S3Y6_FASHE/25-213              qwtqcvvwttllsvltas-----------VVGLF.......G.......LATFQAKPRAVQS.TG...........TVR.........CYQCDNYASVGAEA--RPGVASGLaWMGGKPVLSGQTILSSSgtlvassLTALQASRLCSEKVNRTAMRALITSNSYGtCSGFAYDGCAKIVTKSYRV...KSQLGR...LVLSAVVVSRTCA.H.VPEG...MGVGCFDSVGGAEMRRRLCYCRG.DFCN.....
A0A3P7L7Y5_DIBLA/69-250              .................t-RKPWLPVYLLLAVVL.......G.......SCAFTTLRQSR--.-DrvppllpdpvpPAT.........CYRCDNYANLMIGKNINAQKDVVMiNQFGGN-VIGAGGVGSE.......FGTQAMGELCAERVNRSALADFQ-SGDDF.CEENRYNGCFKMVTKSYRV...AAGLGR...EQLVVTVVTRNCA.E.IPET...ISLGCQKIYGGAGMVRELCYCKG.DYCN.....
A0A0R3W3J8_TAEAS/92-274              ................av--ALSLIIILCFIGIA.......L.......WVAWARSNSSLVG.TDegpq..gpelpPAI.........CYKCNNYAHIMDGRELNSNVDVEH.SEGGAAEVGGALGVAAD.......VDDPRQ-ELCQEFVNRTALAETQSPTDDD.CSDSLYNGCFKMVTKSYRL...TSNVGR...EQLSVTIVTRNCV.E.IPRS...IPLGCYKTFGGAGMERETCYCKG.NYCN.....
A0A0R3X565_HYDTA/58-240              ................av--ALSLIIVLCFIGIA.......L.......WVAWTRSNSNVVK.TDegpq..gpelpPAI.........CYKCNNYAHIMDGRELNSNIDVEH.SKGGAAEVGGALGVAVD.......VDDPRQ-ELCQEFVNRTALAETQSPADDD.CGDSLYNGCFKMVTKSYRL...TSNVGR...EQLSVTIVTRNCV.E.IPRS...IPLGCYKTFGGAGMERETCYCKG.NYCN.....
A0A183PUZ2_9TREM/62-141              .................t-GVYSIRCWLVVISFI.......T.......IAYVTKTNYLEYS.NK...........PIVkq....tqhCFVCDNYASLSDSSGFRPGPGTGLaWFGGKPVVGGWTSI---.......-----------------------------.-------------------...------...-------------.-.----...-----------------------.----w....
A0A183PUZ2_9TREM/138-194             ..................----------------.......-.......-------------.--...........---.........------------------------.-----------------.......-----------------------------.-------------TSIWRV...RPQLGI...PSLTAVVVSRTCA.A.IPEG...YGVGCFNSVGGAGMRRTICYCRG.NFCN.....
A0A267FSI8_9PLAT/9-52                ................lp--SASLAIPLFIALLV.......A.......QCPLPSLAVAD--.--...........---.........CVICDNYFELNSRN----------.-----------------.......-----------------------------.-------------------...------...-------------.-.----...-----------------------.----sk...
A0A4Z2CM70_SCHJA/18-209              .................k-QIYSVWCWLFVFIFI.......T.......LAYVATLIQKEYF.NAs........nkQITqs....vqyCYICDNYASLSADSSMRPGPGTGLaWFGGKPIVGGWTRISSNgnqlqngLTSLQMSRLCSERVNRSAITLLIDSDNYGkCENINYNGCAKIVTKSWRV...RSQLGV...PVLTAVVVSRTCA.T.IPEG...YGVGCFNSVGGAGMRRTICYCRG.NFCN.....
U6J0P5_ECHGR/56-238                  ................av--ALSLIIILCFIGIA.......L.......WVAWARSNSGFAE.ADegpq..gpelpPAI.........CYKCNNYAHIMDGRELSSNIDVEH.SEGGAAKVEGALGVAVD.......VDNPQQ-ELCQEFVNRTALAETQSPADDD.CGDSLYNGCFKMITKSYRL...TSNVGR...EQLSVTIVTRNCV.E.IPRS...IPLGCYKTFGGAGMERETCYCKG.NYCN.....
A0A0R3T6K1_RODNA/32-214              .................a-IVLSLLVTSILVGTV.......A.......WIIWTRLSRSHSW.NDegpl..rsenpPAI.........CYKCSNYFHIMDGREVYSNIDVLK.GESGGTENSGYRGVARD.......VEDPRQ-ELCQEVVNRTALAETQVPLDDD.CGDSLYDGCFKMVTRSFRL...VPNVGR...ERLSVTIVSRNCA.E.IPKN...LALGCYKTFGGLGMERELCYCEG.TYCN.....
A0A183MMH8_9TREM/66-253              .................k-RVYSICCWLVVIIFV.......T.......IAYVTKTNYLEYS.NK...........PIVkq....tqhCFVCDNYASLSDSSGFRPGPGTGLaWFGGKPVVGGWTSMSSNgnhlrngLTSLQISRLCSERVNRSAIKLLIDSENYGkCENINYNGCAKIVTKSWRV...RPQLGV...PSLTAVVVSRTCA.A.IPEG...YGVGCFNSVGGAGMRRTICYCRD.P---si...
A0A654HGC6_9CEST/92-265              .................t-RVPWLPLYLVLAVVL.......G.......GCAFATLRQSR--.-DrvppllpdpvpPAT.........CYRCDNYFNLMFGRRINSQEDVQMvGPFGGS-VIGAGGIASA.......LDKQEEAELCAEYVNRSALVSFQ--SDGDfCEEQRFNGCFKMITKSYRV...TAGLGR...EQLVVTVVTRNCA.E.IPET...ISLGCQKIYGGAGMTR-------.----yfd..
A0A267EXT4_9PLAT/9-52                ................lp--SASLAIPLFIALLV.......A.......QCPLPSLAVAD--.--...........---.........CVICDNYFELNSRN----------.-----------------.......-----------------------------.-------------------...------...-------------.-.----...-----------------------.----sk...
A0A8E0VMY6_9TREM/1-172               ..mvglfrlatfqskarv----------------.......-.......---------IRSP.GG...........EVR.........CYECDNYASVGAET--RPSAASGLvWMGGKPVLSGQTILSSSgtvmgssLTALQASRLCSETVNRTAMRRLITSKSYGkCSGVRYDGCAKLVTKSYRV...KSQLGR...LVLSAVVVSRMCA.H.IPEG...MGVGCFDSVGGAEMRRRLCYCRG.NFCN.....
A0A5J4P2I1_9TREM/73-251              ............wtvyac-------CAAFVVLTI.......AslfgyhqSAYLTNSAGQPIS.RP...........PTR.........CYTCDNYASVETGV--RPGVGSGLaWLDGKPVQGGWSKLASHgvn.sngLTAVQASRLCSERVNRTGMRRLIDSRDYGeCPNANYDGCVKLVTKSYRV...KAQLGV...PVLSAIVVSRTCA.I.IPEA...MGVGCFDSVGGAAA---------.----kcqet
#=GC seq_cons                        .................s.....l.hhhhlhhhh.......h........s.hsp.t......tt...........shh.........CYhCsNYApl.sup..pst.ssth...sGts.hsGhhthusp.......lss.ptscLCpEhVNRoAhtth.ssts.s.Cts.tYsGChKhVTKSaRl...psplGh....pLossVVoRsCA.p.IPcu...hulGCapohGGAGMcRphCYC+G.saCN.....
//