#=GF ID   DUF587
#=GF AC   PF04532.16
#=GF DE   Protein of unknown function (DUF587)
#=GF AU   Kerrison ND;0000-0002-1471-953X
#=GF SE   DOMO:DM04375;
#=GF GA   25.00 25.00;
#=GF TC   27.10 131.70;
#=GF NC   22.40 21.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR007618;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of the N termini of some human herpesvirus
#=GF CC   U58 proteins, and some cytomegalovirus UL87 proteins. This
#=GF CC   region is always found N terminal to the Pfam family UL87
#=GF CC   (Pfam:PF03043), which has no known function.
#=GF SQ   28
#=GS UL87_HHV6U/1-214        AC P24437.1
#=GS B7TPZ2_9BETA/7-227      AC B7TPZ2.1
#=GS A0A0S1TPT1_9BETA/1-213  AC A0A0S1TPT1.1
#=GS A0A0F7GA30_SCMVC/9-220  AC A0A0F7GA30.1
#=GS Q2FAJ0_9BETA/8-221      AC Q2FAJ0.1
#=GS UL87_HHV6Z/1-214        AC Q9QJ25.1
#=GS Q7TFL5_RHCM6/8-221      AC Q7TFL5.1
#=GS M1RG09_ELHV1/2-215      AC M1RG09.1
#=GS G8XTY4_SCMVC/9-220      AC G8XTY4.1
#=GS UL87_HCMVM/7-227        AC Q6SW55.1
#=GS A0A0G2UGJ0_9BETA/8-221  AC A0A0G2UGJ0.1
#=GS G8XUF3_9BETA/7-226      AC G8XUF3.1
#=GS UL87_HCMVA/7-227        AC P16730.1
#=GS H2A2B8_MUHV1/13-222     AC H2A2B8.1
#=GS U6HC46_9BETA/7-227      AC U6HC46.1
#=GS K7XR28_RCMVE/10-221     AC K7XR28.1
#=GS A0A075CZT8_9BETA/3-216  AC A0A075CZT8.1
#=GS A0A191S3S8_9BETA/5-213  AC A0A191S3S8.1
#=GS UL87_HHV7J/1-213        AC P52363.1
#=GS I3VQ80_9BETA/2-231      AC I3VQ80.1
#=GS A0A1L6Z109_9BETA/8-221  AC A0A1L6Z109.1
#=GS Q91TL0_TUHV1/7-218      AC Q91TL0.1
#=GS Q8QS12_9BETA/6-237      AC Q8QS12.1
#=GS Q9DWB5_RCMVM/10-221     AC Q9DWB5.1
#=GS A0A1P8VIW0_9BETA/2-200  AC A0A1P8VIW0.1
#=GS G8XSZ2_9BETA/9-220      AC G8XSZ2.1
#=GS A0A0K1GZP4_9BETA/8-221  AC A0A0K1GZP4.1
#=GS M4JUZ3_ELHV1/2-215      AC M4JUZ3.1
UL87_HHV6U/1-214                   ..............MQHTGNCETLIVNSCFGSTCAR---SIPVFIDSCDLTAEVSRDEETRLARSMPV..VLE..KIESIIEKIFQTSGP.NI............VHDKDRAKIALCRLLLGPVAVPCFC-.....-EEWDTN........DYLSKSGCKCIGPILYIHTSRCRC.......SDIP--........-VFKFSIMKDYYASHVFRGLLSLKEWNTHLP.NVLCTC-----ELSMSDRYVATVYPKQNSIYLEYYPYFLCYLCRHLTVIEIEQCTNDLI...
B7TPZ2_9BETA/7-227                 lspslivtsdrfig-----------------------VRSVPVSVDSHNLTRELSSEEDGRVATPVQV..DHD..HVDEIFDVLLDASPVpNVpasngdaasgldTRDRDRARVVLCRLLLGPTAVPCYC-.....-DEWDAD........EYLTECVFRCEGPLLYAYRKGCQC.......YEAS--........-ALQFTVICNHPVNRAFRGLLSLMEWNAHLR.NVFCGC-----CRYRTDRYVLAALPARYPIFLVYYPYFLRCLCRYLSVAEIDDCTNA--mm.
A0A0S1TPT1_9BETA/1-213             ............mt-------DALIVQS--GSSSSCKCYIVPVCVDNVDLTTEIARSEEKFLTAQNKYgnDPH..YVENLFKNLYLNAPS.HL............T-CREKCSLILRRLLLGPVAVPCMT-.....-ETWDKN........EYMNENPIGTVKGTLYVYKKCCKC.......HN---G........AAFNCTVLTDCASTHVFRGLLSTQRWEGDTAeHMICFC----NKAAFGTDYTALILPAEHPITLDLYPQFLNILTRHLSVCEIDTLTNETI...
A0A0F7GA30_SCMVC/9-220             .........gcraa------QDALIVDS---VAEPQ-VVNVPVHVNSYNLTQELSSVEDARFCQTRPV..DAE..RVRAVFGALYRSASP.HM............REESDRIKLILGRLLLGPVAVPCYC-.....-DEWEAN........DYMVESPQFCAGPLLYVH-RRCHC.......PN--AG........RSLAFTVMEGHIATHVFRGLLSLTEWNQHLL.DMFCPC----GTVSRRDRYSMACLPRHLTLYISDYPYFMVEIGRVLTVSEVDDYVN---lm.
Q2FAJ0_9BETA/8-221                 .........fqcra-----AQDALIVES---TAEP-QVVNVPVHVNSYNLTQELSSVEDARFCQTQPV..DAE..RVRGVFGALYRAAAP.HL............REESDRIKLILGRLLLGPVAVPCYC-.....-DEWEAN........EYMVDAPQFCGGPLLYVH-RRCHC.......PIVG--........RALAFTVMEGHIATHVFRGLLSLSEWNQHLP.DMFCPC----GSLDRRDRYSMACLPRDLTLYINDYPYFMMEIGRVLTVSEVDDYVS---lmi
UL87_HHV6Z/1-214                   ..............MQHTGNCETLIVNSCFGSTCAR---SIPVFIDSCDLTAEVSRDEETRLARSVPV..VLE..KIESIIEKIFQTSGP.NI............VHDKDRAKIALCRLLLGPVAVPCFC-.....-EEWDTN........DYLSKSGCKCLGPILYIHTSRCRC.......SDIP--........-VFKFSIMKDYYASHVFRGLLSLKEWNTHLP.NVLCTC-----ELSMSDRYVATVFPKQNSIYLEYYPYFLCYLCRYLTVIEIEQCTNDLI...
Q7TFL5_RHCM6/8-221                 .........fqcra-----AQDALIVES---TAEP-QVVNVPVHVNSYNLTQELSSVEDARFCQTQPV..DAE..RVRGVFGALYRAAAP.HL............REESDRIKLILGRLLLGPVAVPCYC-.....-DEWEAN........EYMVDAPQFCGGPLLYVH-RRCHC.......PIVG--........RALAFTVMEGHIATHVFRGLLSLSEWNQHLP.DMFCPC----GSLDRRDRYSMACLPRDLTLYINDYPYFMMEIGRVLTVSEVDDYVS---lmi
M1RG09_ELHV1/2-215                 ........niqhke-------DTLIVQT--GGNYKY--YSVPVCVDSIDLTTEIARSEEKLLTGPSKH..VEDpsYIESLFKNLYLNAPE.YL............KC-QERCFLILKRLLLGPTSVPCAV-.....-ETWDKM........DYMNENPITTQNGTLYVYKKCCKC.......PNNC--........-LFNCTVLTNYGTSHVFRGLLSLKKWETDTE.PMICFC----NRAVPNSEYIAVIFPGEQKITLDMYPHLLNILTRYISICDIDTITNDLI...
G8XTY4_SCMVC/9-220                 ........qcrapq-------DALIVES---AAEPQ-VVNVPVHVNSYNLTQELSLVEDARFCQTRPV..NAE..RVRGVFGALYRAASP.HM............REESDRIKLILGRLLLGPVAVPCYC-.....-DEWEAN........DYMVEAAQFCAGPLLYVH-RRCHC.......PGMG--........RALAFTVMEGHVATHVFRGLLSLTEWNQHLP.DMFCPC----GTASRRDRYSMACLPRDLTFYISDYPYFMVEIGRVLTVSEVDDYVS---lm.
UL87_HCMVM/7-227                   ...........rrl-----GCDALIVVG--GSAMPRRVLHVPVHVRACNLTQELSTGEDARFCRPRPV..NVE..RVRAVFAALYRACPI.HV............RTEPERVKLVLGRLLLGPVAVPCFCD.....GEVEGHG........EHLVPTTQFCRGPLLYVH-RRCCC.......GSVTAG........RALSYHVLENHVATHVLRGLLSLTEWNRELP.SLFCDCPGGGGASGTEERYAMACLPRDLSLHLDDYPYLMVEIGRVLSVSEVDDYVT---av.
A0A0G2UGJ0_9BETA/8-221             .........fqcra-----SQDALIVDS---AAEPQ-VVNVPVHVNSYNLTQELSSVEDARFCQTRPV..DAE..RVRAVFGALYRSASP.HM............REESDRIKLILGRLLLGPVAVPCYC-.....-DEWEAN........DYMVESPQFCAGPLLYVH-RRCHC.......PN--AG........RSLAFTVMEGHIATHVFRGLLSLTEWNQHLP.DMFCPC----GTANRRDRYSMACLPRDLTFYISDYPYFMVEIGRVLTVSEVDDYVN---imt
G8XUF3_9BETA/7-226                 .......trsggse-------CALIVESS-RERSALGVLNVPVHVNSHNLTQELSVEEDARFARSAPV..NAE..RVRTVFRALYAAGPN.HV............NGERDRTKIVLCRLLLGPVAVPCYC-.....-DEWDTN........EYMAEHSRFCAGPLLYVH-RQCRCr.....gGTAVSG........QRLAFSVMKGHQSTHVFRGLLSLSEWNVHLP.RMFCSC-----LSFTSDRYVMACLPGSMSLHLDDYPYLMGEIGSVLNIAEIDECVQAM-v..
UL87_HCMVA/7-227                   ...........rrl-----GCDALIVVG--GSAMPRRVLHVPVHVRACNLTQELSTGEDARFCRPRPV..NVE..RVRAVFAALYRACPI.HV............RTEPERVKLVLGRLLLGPVAVPCFCD.....GEVEGHG........EHLVPTTQFCRGPLLYVH-RRCCC.......GSVTAG........RALSYHVLENHVATHVLRGLLSLTEWNRELP.SLFCDCPGGGGASGTEERYAMACLPRDLSLHLDDYPYLMVEIGRVLSVSEVDDYVT---av.
H2A2B8_MUHV1/13-222                ........scldpa---------LIVKS----PTAR-VKSAPVCVNSYNLTREISPFEDSRLSQAVTV..DEE..HISSIFRTLMAAGPD.PG............ATDEDKARVVLCRLLMGPVAVPCYC-.....-DEWDVD........DYLAKCAYRCSGPALYVHRSRCRC.......GAEGGG........--TMFTLLHDHYTTHVFRGLLSLSEWNVRLT.DVFCAC-----NAFRSDRYVMAVLPKHQSVFIEYYPYFLVCLARYLTVPEIDDCANS--mt.
U6HC46_9BETA/7-227                 lspslivtsdrfig-----------------------VRSVPVSVDSHNLTRELSSEEDGRVATPVQV..DHD..HVDEIFDVLLDASPVpNVpasngdaasgldTRDRDRARVVLCRLLLGPTAVPCYC-.....-DEWDAD........EYLTECVFRCEGPLLYAYRKGCQC.......YEAS--........-ALQFTVICNHPVNRAFRGLLSLMEWNAHLR.NVFCGC-----CRYRTDRYVLAALPARYPIFLVYYPYFLRCLCRYLSVAEIDDCTNA--mm.
K7XR28_RCMVE/10-221                .......smscvdk--------ALIVKS----TAAR-VKNAPVCVNSHNLTREIAPFEDSRLSQPVSV..DEE..HISSIFGSLMSACPD.AS............ATDEDRARIVLCRLLLGPVAVPCYC-.....-DEWDVD........EYMAKCAYRCSGPALYVHRARCRC.......GADGG-........-GTMFTMLYDHYTTHVFRGLLSLAEWNTRLV.NVFCDC-----NKYRSDRYVMAVLPKHYSIVLDYYPYFLVCLARYLTVPDIDDCVNS--mt.
A0A075CZT8_9BETA/3-216             .......lqytedt--------TLIVQT--GGNYK--YYSVPVCVDSIDLTTEISRSEEKLLTGPGKH..VEDpyYIESLFRNLYLNAPG.HL............KC-QEKCFLILKRLLLGPTSVPCAV-.....-ETWDKT........DYMNENPISTENGTLYVYKKCCKC.......PNNC--........-LFNCTVLTNYGTSHVFRGLLSLQKWETETE.PMICFC----NRAVPNSEYIAVIFPGEQRITLDMYPYLLNILTRYISICDIDTVTNDLI...
A0A191S3S8_9BETA/5-213             ...........lfk-------ETLIVND--KNTLHN-AKNIPVFVDSYDLTAEVARSEDQRLAKQVNI..SLE..KINEIIKVIFSTSGP.SI............RNVKDQAKLTLCRLLLGPVSVPCYC-.....-DEWDVN........SYLHKRSYDCIGPVLYIYRNNLNC.......CENP--........--YRFSIMENYHSTHIFRGLLSLTEWNQHLP.NILCTC-----SNVMNDKYTATIFPKNISIYMEYYPYFLCFLCKYLSIIDIEQCTNELI...
UL87_HHV7J/1-213                   ........midsis------EETLIVKSYTVNHCAK---NVPVFINSYDLTAEVAKNEDVRLARQVQI..SLE..KIDEVIESIFSASGP.SV............ENVKDQAKFALCRLLLGPVSIPCYC-.....-EEWDVN........FYLTKCSYNCEGPVLYIYKNASQC.......CEST--........--YRFSIMTNYHSTHIFRGLLSLQEWNSHLS.NILCTC-----SNVTGDKYTATIFPNNASIYLEYYPYFLCYLCKHLSIIDIEQCTNELI...
I3VQ80_9BETA/2-231                 .........tstty-----GGESLIVGT----SLSQ-VRNAPVYVNSCNLTREISCEEDARLSQSVVV..NEA..HVDEIFDVLFSACPP.TA............VTNADRAKVVLCRLLLGPVAVPCYC-.....-DEWDAD........EYTARCAYECTGPVLYVHRGRCRClapvaadGGVEAGistvsnarQPMRFSLMQGHAATHVYRGLLSLTEWNVGLK.NLFCEC-----TVFKSDRYVMAVLPERYCLFLDYYPYMLRHICRFITVPEIDDCTNA--ml.
A0A1L6Z109_9BETA/8-221             .........fqcra-----AQDALIVES---TAEP-QVVNVPVHVNSYNLTQELSSVEDARFCQTQPV..DAE..RVRGVFGALYRAAAP.HL............REESDRIKLILGRLLLGPVAVPCYC-.....-DEWEAN........EYMVDAPQFCGGPLLYVH-RRCHC.......PIVG--........RALAFTVMEGHIATHVFRGLLSLSEWNQHLP.DMFCPC----GSLDRRDRYSMACLPRDLTLYINDYPYFMMEIGRVLTVSEVDDYVS---lmi
Q91TL0_TUHV1/7-218                 .......agapagp---------LIVDSGLVS-KAR---SAPVYVNAWNLTREISAEEDARLSQSVPV..DPE..HVDRLFELLFAASPA.TA............ASDRDRARIVLCRLLLGPVAVPCYC-.....-EEWEAN........ELLMRGAYACRGPVLYVHRGRCRC.......GTPY--........DTLQFTVMTGQRSTHVLRGLLALMEWNFHLP.TLFCRC-----VEFQSDRYVMLVLARGYAIHLDYYPFLLRHLCRFLTVPEIDDCTNAM-i..
Q8QS12_9BETA/6-237                 ...........rra-----GRDALIVES----PAARRVLNVPVHVNSYNLTQELSTGEDARFCRPRPV..DAE..RVRAVFAALYRACPA.HV............RAEADRVKLVLGRLLLGPVAVPCYCDewvtaGEEEDDDgaaarllrEHLAETAQFCRGPLLYVH-RRCRC.......AGGGAQ........RPLAFSVMEGHVATHVFRGLLSLAEWNCQLP.GLFCPCVVGGAAAAATERYALACLPRDLSLHMDDYPYLMVEIGRVLGVSEVDDYVG---al.
Q9DWB5_RCMVM/10-221                .......sragsep--------ALIVKS----PAAR-VKNAPVCVNSHNLTREIAPFEDSRLAQPVAV..DED..HITAIFRLLMAAGPD.AG............ATEEDRARVVLCRLLLGPVAVPCYC-.....-DDWDVD........DYMARCAYRCSGPALYVHRARCRC.......GADG--........GGTMFTLLHDHYTTHVFRGLLSLAEWNVRLV.DVFCAC-----NRFRSDRYVMAVLPKHFSVFIAYYPYFLVCLARYLTVPEIDDCVG---smt
A0A1P8VIW0_9BETA/2-200             ..........ednc-----------------------IRSIPVFLEECDLTHEISRDEDFRISQNVSI..NYD..KIDDIIHCLFWAPCS.PS............MTEKDRAKLTLCRLLLGPATIPCSC-.....-EEWDVT........DYLHECGYNCTGPILFLYKNNCKC.......R-VN-G........TTFGYSLLKNYCGSHVIRGLLSLYEWNVNIP.NLLCQC-----KIKHMDRYAATVLPKSKSIYLTYYPYFLCFLTKYLSVLEIEECMNNLI...
G8XSZ2_9BETA/9-220                 ........sreges--------ALIVES----FRQRYVLNVPVHVNSYNLTQELSMEEDARFARSVRV..DVE..RVRAVFRTLCEACPL.HV............TTERDRVRIVLCRLLLGPVAVPCYC-.....-DEWDTN........EYMVEYTHFCSGPLLYVH-RRCRC.......RT-PAG........QGLAFSVMRGHQTTHLFRGLLSLAEWNQHLP.RMFCAC-----MTFTSDRYVMACLPSALSLHLDDYPYLMGEIGHFLTITEIDECVQAM-v..
A0A0K1GZP4_9BETA/8-221             .........fqcra-----AQDALIVES---TAEP-QVVNVPVHVNSYNLTQELSSVEDARFCQTQPV..DAE..RVRGVFGALYRAAAP.HL............REESDRIKLILGRLLLGPVAVPCYC-.....-DEWEAN........EYMVDAPQFCGGPLLYVH-RRCHC.......PIVG--........RALAFTVMEGHIATHVFRGLLSLSEWNQHLP.DMFCPC----GSLDRRDRYSMACLPRDLTLYINDYPYFMMEIGRVLTVSEVDDYVS---lmi
M4JUZ3_ELHV1/2-215                 ........niqhke-------DTLIVQT--GGNYKY--YSVPVCVDSIDLTTEIARSEEKLLTGPSKH..VEDpsYIESLFKNLYLNAPE.YL............KC-QERCFLILKRLLLGPTSVPCAV-.....-ETWDKM........DYMNENPITTQNGTLYVYKKCCKC.......PNNC--........-LFNCTVLTNYGTSHVFRGLLSLKKWETDTE.PMICFC----NRAVPNSEYIAVIFPGEQKITLDMYPHLLNILTRYISICDIDTITNDLI...
#=GC seq_cons                      ..........ppps.......-sLIVpS...sstsp.VhsVPVaVsSaNLTpElSssEDuRhspsssV..stE..+VculFcsLapAuss.pl............pp-pDRsKllLsRLLLGPVAVPCYC.......-EWDss........-Yhs-sshhCtGPlLYVH.+RC+C.......ssss..........tshsFTVhcsHhuTHVFRGLLSLsEWNp+Ls.shFCsC.....stspsDRYshAsLP+cholaL-.YPYFhsplsRaLoVsEIDDhsNt..h..
//