#=GF ID DUF6001
#=GF AC PF19464.3
#=GF DE Family of unknown function (DUF6001)
#=GF AU Williams LS;0000-0001-5551-8526
#=GF AU Finn RD;0000-0001-8626-2148
#=GF AU Fragoso S;0000-0001-7018-3891
#=GF SE Manual
#=GF GA 25.00 25.00;
#=GF TC 27.60 92.30;
#=GF NC 24.30 24.00;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF WK Domain_of_unknown_function
#=GF RN [1]
#=GF RM 9353942
#=GF RT The phtE locus in the phaseolotoxin gene cluster has ORFs with
#=GF RT homologies to genes encoding amino acid transferases, the AraC
#=GF RT family of transcriptional factors, and fatty acid desaturases.
#=GF RA Zhang YX, Patil SS;
#=GF RL Mol Plant Microbe Interact. 1997;10:947-960.
#=GF RN [2]
#=GF RM 17237165
#=GF RT Functional characterization of the gene cluster from Pseudomonas
#=GF RT syringae pv. phaseolicola NPS3121 involved in synthesis of
#=GF RT phaseolotoxin.
#=GF RA Aguilera S, Lopez-Lopez K, Nieto Y, Garciduenas-Pina R,
#=GF RA Hernandez-Guzman G, Hernandez-Flores JL, Murillo J,
#=GF RA Alvarez-Morales A;
#=GF RL J Bacteriol. 2007;189:2834-2843.
#=GF DR INTERPRO; IPR046043;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This entry represents a member of a biosynthetic gene cluster
#=GF CC (BGC). This BGC (BGC0000919) is described by MIBiG as an example
#=GF CC of the following biosynthetic class, other (unspecified). This
#=GF CC family includes a protein from the phaseolotoxin biosynthetic
#=GF CC gene cluster from Pseudomonas syringae [1].
#=GF SQ 14
#=GS G2NC26_STREK/12-372 AC G2NC26.1
#=GS A0A059W6L5_STRA9/11-369 AC A0A059W6L5.1
#=GS A0A0N1NDH0_9ACTN/10-354 AC A0A0N1NDH0.1
#=GS A0A1E7N436_KITAU/11-369 AC A0A1E7N436.1
#=GS A0A1H6BNC8_9ACTN/3-355 AC A0A1H6BNC8.1
#=GS A0A0F5JU34_9BURK/2-348 AC A0A0F5JU34.1
#=GS A0A0N1NKG8_9ACTN/1-341 AC A0A0N1NKG8.1
#=GS A0A3S0GZE8_9BURK/5-350 AC A0A3S0GZE8.1
#=GS A0A5P0YND9_9ACTN/574-935 AC A0A5P0YND9.1
#=GS A0A542QM47_9ACTN/11-368 AC A0A542QM47.1
#=GS A0A0Q7WM39_9HYPH/8-358 AC A0A0Q7WM39.1
#=GS A0A0B6S6X8_BURPL/2-347 AC A0A0B6S6X8.1
#=GS A0A3N7HI80_9BURK/2-347 AC A0A3N7HI80.1
#=GS A0A124I8G8_9ACTN/12-372 AC A0A124I8G8.1
G2NC26_STREK/12-372 .......LSPDELTARRHAQVTAFLEGRDLDPGWLSDLMRERV.G.EG.LLLLTSSPVHGLANPTSDLDFIRIQEAAIDGPR.ISTKIFENGHHLEVVSFSEAELASNLDELERLASLPAEGTVAGFRAWDKQREPRRKQTERIVNGIAMDGSAPYLGALPALGRVWSRAALHTAVEQVVHTTLAEKAGEARGRVGYAYNVLLHLMDALLSHHGDVYTTRKWYVLRWTRLMAEGGWH...DEHLQSV.AVGL.ERLRKDVHT.FLA.PDLAGEPLAAPFAELALAAV..RATG.TARGVTVGVELTGGVE...AFLPGSALL.LGPDGGV....VLPGVgtASDLPFTGAPVGLDGLAALDAPAAATLLRALRAGAARLRIGYQDEEDG-r.........
A0A059W6L5_STRA9/11-369 .......LSPAELTARRHAHVAEFLAGRGLDPHWLTALMRERV.G.EG.QLLLTSSPVHGLANATSDLDFIRIQADEIHGPR.ISTKIFVDGHHLEVVSFSEAELASNLAELARLAAAPPAATVAGFRSWDKQREPRRKQTERIVNGIALDGTAPHLAALPALSTVWSRASLHTALEHVVHTALAEAAGESRGRVGYAYNALLHLMDALLSHHGDVYTTRKWYLLRWARFVAEDAWP...DDAVRAA.GAEL.ERLRKDVAA.ALD.PTAGARPLAGEYVALAQECL..RATG.TAATATVRLELTGTLQ...PFLPGAALL.VAPGGSV....VLPGV..TDTLPLAGEAIGLDALGKLDPHDAATLLRALRAGAARLDIGYHGEETTA..........
A0A0N1NDH0_9ACTN/10-354 .....ap-APPAAARLR--NADAFLATRGLTRAGLDELMRAKT.G.DArHLLLTSSPVHGIANATSDIDFIRVEDHAVQGAR.MATQLFEQDQHLEAVSYGAAEVDDALADLAKAAALDPADVVLAHQGWDKGHELRRKYLERLINGLSLDGSSPYLEHLPQLARVWKWSALHTAVRHVFHLRLAEAAGESRGSAGYALGALLHLADAALSHAGDVYSNRKWFLLRWQRFLAAGTAD...GTALAPF.ADRL.TDLDLRVRQ.ALR.GE-SGAPLAPAFAAALAELF..EIAG.EGHEPALLLDVAEDTRp.lAFLPGASML.VGATALFa..dAVPAVgrLAVTPGAELPA-----------DPAGLLSASRAGVLRLLP---------a.........
A0A1E7N436_KITAU/11-369 .......LSPDDLAARRHGHVSAFLSGRGLDPDWLSALMRERV.G.EG.LLLLTSSPVHGLANATSDLDFIRIQRDPIEGPR.ISTKIFEDGHHLEVVSFSEAELASNFAELRRLAGLAPEAAVAGFRGWDKQREPRRKQTERIVNGIALDGTAPFLDELPGLATVWSRASLQVALEQVAHTALAEAAGESRGRVGYAYNVLLHVMDALLSHHGDVYTTRKWYALRWSRLVADGTWR...SDRVAAV.AADL.ERLRKEIAG.TLA.PSAAAQPLAAAYTQLALDTV..RATG.TAEAVTVRVEVTGTLR...PFLPGASLL.VAPGGSV....VLPGL..TGDLPLTVDPVALTDLGRLDAQDAATLLRALRSGAARLDIGYRNEEVPA..........
A0A1H6BNC8_9ACTN/3-355 ......l-STTRLAEQRHANVTTFLRSRQLDPAALGALMTERV.G.PG.QLLITSSPVHGLANATSDLDFIRIQDEPLEGAR.ISTKIFEWGEHLEVVSFSAAELAANLKELTDLAIRPPEEIVKVFRSWDKHREPRRKQTERIINGVTLDGQMPYVAALPALAAVWSRAALQSSIEQAVHLALAEAAGELRGRAGYAINTLLFLMDAILSHHGDVYTTRKWYLLRWTRLVAEQGWA...DASFAAL.GAKV.ERLRVTVAS.ALTrPD---ARIAADYLALVREAA..ALTA.QTHSVSVAFDPADRADr.yAFLPGAELL.LTSDGAM....PAS--..-GQAPA--GPYALTGLGAIPGREAGVLLRALRGGALAQRIDYTG-----gtsa......
A0A0F5JU34_9BURK/2-348 .nysafy----------SGNAKAFLAARNLSFDDLDTVVRRQY.D.DAeLTLITSSPVHGVANAASDIDLICITDAMQSSDA.MASQVYHNGHHMEVVAFASDEVLAACHELTVQQGKLPIDMLRVYRQWDKKQRISRKYLERIIAGVATDGSVPYLEWQGTLGATWSIASFDAFRQSAGFALLALRCKETRAAAGYATNALLYLMNAMLSKSGWTVSNKKWTLLRWHQA--TDSLR...IWSNVRL.VDVI.DSLWDSIYP.SCT.TG-LTEQLAERLVELVDLAE..SHFGyEVDYARLRPALRATSN..aPFLPGSVFT.LRSDGRA...aLLPTV..DISDALTTHPR---DLRATTPDVARHLLIGARVGVIG------------fsltds....
A0A0N1NKG8_9ACTN/1-341 .......MAITPETRLR--HVDTFLASRGLTFDGLEPLLTGRT.G.AArHFLLTSSPVHGLANSTSDVDFIRIQAEPMTGAR.MATQLFEGPNHLESISFAADEVDAALTDLRALAGAGPREAVLAYRGWDKRHEFRRKHLERSVNGVALDRTLPYLDHLPELARLWKWSSLHTATEQVLFLSLAEAAGGRRGRVGYAVNALLYLMDAVLSHHLDVYSNRKWFLLRWTRF-----RQ...LHAAEPV.VAAV.DALRSPVSE.ALAgKD--TGPLAPALTALLTEVY..AVAG.EGHAPTLAVAPAGEPVr.qRFLPGADML.LGSSTAFlgqePLP--..AGEIPLADLPGCVA--------APVDLLRAARAGAVTLLP---------aa........
A0A3S0GZE8_9BURK/5-350 ...dfvt-----------ANAAAFLRDRHIGFDLLATLAREQGfD.DA.QVLLTSSPVHGIATATSDIDLICVTPQAVSRGQ.MATQIHRDGQHCEILPIGAQDLERAFADLAALSRRALPQRLADYQRWDGEHAVRKKYLERIVYAVATDGHAHHLGHLPALVPVAAAQEYDAFHQSRVCAMLAERAGEPEGARGYLINACLFAMAAALSLGGWVLSNKKWTLRRWHEA---ATSR...VGLLDPVlKDRL.TALWSAVCE.FA-.PAATALEIAALDEIAARLAL..LMDA.LSLADALPHTAASCTQ..aALDKRSAFL.IGDDGYA....RLAA-..--TAGMQAAPPDLAGLATLTSTQAASLLRGARSGALSFS----------ltaidaca..
A0A5P0YND9_9ACTN/574-935 ......r-SAADLVERRHRNVAAFLAGRSLEAKWLSDLMRERV.G.EG.LLLLTSSPVHGLANPTSDLDFIRVQEAPIDGPR.ISTKIFEDGHHLEVVSFSRAELASNLEELHRLAGLPVEETVAGFRRWDKEREPRRKQTERIVNGLTLDGSAPFVDWLPPLGRVWSRASLQLAVEQAVHCLLAESAGETRGRVGYAYNVLLHLMDALLSHHGDVYTTRKWYALRWARMTAQGGWH...DNRLEAV.ATDL.ERLRKGVGA.TLR.PSAATEPLAGAFAALTLDAV..RATG.TASAVTVAVEAEGPGVvakPFLPDASLL.LNAGSAV....VLPGVgaEDGLPLAGAPVGLDELAGLDARSAATLLRALRAGVARLRIGYPD-----gta.......
A0A542QM47_9ACTN/11-368 ......l-PPEELTSRRHASVSAFLAGRSLDPAWLAGIMREQV.G.EG.QLLLTSSPVHGLANATSDLDFIRIQEEEIEGPR.ISTKIFEEGHHLEVVSFSRTELASNLDELNRLAALAPDATVAGFRSWDKQREPRRKQTERIVNGISLDGTAPYVEWLPALGTVWARASLQTALEQVVHTALAEAAGETRGRVGYAYNVLLHLMDALLSHHGDVYTTRKWYVLRWTRLVAEGSWR...DERVQAV.AADV.ERLRKGIAD.TLD.ASAADQPMAQAYVALALDVV..RASG.TAGSVSVRAEMTGSMQ...PFLPGASLL.VAPGGGV....VLPG-..TGELPLTARAVGLDDITGLGSSEAASLLRALRAGAARLRIGYGEEEATA..........
A0A0Q7WM39_9HYPH/8-358 sayqddt------LRRGRHNVDQFFASQGLDKAEFEKFVLERS.D.PShRPFYVSTVARGLASSTSDIDIMLVADGPLPENHaTSNMLFFQQRRVGLKLLSGANIETTLDTLESATAHPTLQAIVLNARLTEDMPVRWVDLERITNGVPFSDGESYHHRLATLCGATAASRLKDYLFNALFLRLAVKAGLAESAYAYGQLALMAAMDVLMASCGHVQSNMKWIFERWSHF-AVDA-K...RPAVREG.VALL.TALHENLDAgGLS.KE----PGQLTLFEAVNAYFerRIFP.SDRLPAIRLALAQGVRa.hGFLPNATSLhLKDAAAV....VGSAI..VDHLQTAGTNATND-F--ATPRDAATALRLLQHG---------------flyaave...
A0A0B6S6X8_BURPL/2-347 ..dycaf---------HSGNAEAFLDSRNLSFASLESVAKLQY.D.DVkCTLVTSSPVHGVANAASDIDLICITAADDDRGA.MASQIHHDGQHLETVAFATGDVETAMRALAGYRAAGPLDTLLAYRRWDATQAVSRKYLERIVSGVATDRGVPYLGWHTALGGMWAVAAFDAFRQSAGFALLALRCGETRGAGAYAANALLHLMNAMLSRRGWTVSNKKWTRLRWRRA--SGSLL...AGDDAAA.IEAI.DALWRDTLP.ACT.AG-LTEADAARLVALVELAD..ADFGfEEAYATLRPKLRQPER..aPFLPGSHVV.LRQDGRA...aLLPGV..ETPASLTAQAR---DLAAVSPELARHLLAGARAGVIG------------fsltd.....
A0A3N7HI80_9BURK/2-347 dypaflt-----------ANALEFLNSRGLPQEELSRLAHKQG.FeDA.LLLLTSSPVHGIATATSDIDLICISTQAVSRAQ.MATQIHHQGQHVELLPFCAADVETSFAAWSALARCDLPDLLAGYQRWDATNPVRRKYLERLVYGVELRGGTPFVSHLGSTAHIVAAADFDTLQQAHACAWLAARAGETHAARGYLLNACLSAMSVLLSLGGWVVSNKKWTLRRWTL--AQGGGMdilDAALQRT.ASRLwAALTEPATH.TSR.SLDLLDQLRADLARLLTQGP..SAAL.HHPAPTEHLHSPMDAR..sAFIHGDAAW.SRMESSA....ALP--..-------ETPADLDGLRSLPPDHAQRLLRAVRCGE--------------wacslrapda
A0A124I8G8_9ACTN/12-372 .......LSPDELTARRHAQVTAFLSGRGLEPGWLSDLMRERV.G.PG.LLLLTSSPVHGLANPTSDLDFIRIQEAEIDGPR.ISTKIFEDGHHLEVVSFSEAELASNLDELNRLAALPAEQTVAGFRAWDKQREPRRKQTERIVNGIAMDGSAPYLPWLPALSRVWCRAALQTAVEQVTHATLAEAAGETRGRVGYAYNVLLHLMDGLLSHHGDVYTTRKWYALRWTRLMSEGGWH...DERLQSA.AAGL.ERLRKEVHT.FLD.PAAAAEPLAAPLTELALDAV..QATG.TARSVTVGVELTSRVR...AFLPGAAVL.VGKDSGV....VLPGVgtESDLPLTAAPARLDELSALDAPAAAALLRALRAGAARLRIGYLDEEAG-r.........
#=GC seq_cons ........s....sthRpusVsAFLuuRuLs.shLssLhRE+s.G.-u.hLLLTSSPVHGLANATSDlDFIRIpctslsGsR.huTpIFcsGcHLElVSFutAElsosLs-LspLAuhsstpsVsuaRpWDKp+EsRRKphERIVNGluhDGosPYLsaLPuLupVWutAuLcsulcpssastLAEtAGEoRGpsGYAhNsLLaLMDAlLSH+GDVYosRKWalLRWsRh.Apuuhc...sstlpss.ustL.-pL+cslss.sLs.ss.hspPLAushstLstpsh..pssG.pupusoltlchsussp...sFLPGAuhL.lsssuus....lLPul..tsshPhsstPssLssLsslsspsAAsLLRAlRuGshph...........h.........
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