#=GF ID DUF6002
#=GF AC PF19465.3
#=GF DE Family of unknown function (DUF6002)
#=GF AU Williams LS;0000-0001-5551-8526
#=GF AU Finn RD;0000-0001-8626-2148
#=GF AU Fragoso S;0000-0001-7018-3891
#=GF SE Manual
#=GF GA 25.00 25.00;
#=GF TC 37.70 54.60;
#=GF NC 19.70 20.30;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF WK Domain_of_unknown_function
#=GF RN [1]
#=GF RM 18288655
#=GF RT Assembly and heterologous expression of the coumermycin A1 gene
#=GF RT cluster and production of new derivatives by genetic
#=GF RT engineering.
#=GF RA Wolpert M, Heide L, Kammerer B, Gust B;
#=GF RL Chembiochem. 2008;9:603-612.
#=GF DR INTERPRO; IPR046044;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This entry represents a member of a biosynthetic gene cluster
#=GF CC (BGC). This BGC (BGC0000833) is described by MIBiG as an example
#=GF CC of the following biosynthetic classes, saccharide and other
#=GF CC (unspecified). This family includes a protein from the
#=GF CC coumermycin A1 biosynthetic gene cluster from Streptomyces
#=GF CC rishiriensis [1].
#=GF SQ 70
#=GS A0A1B1MGK4_STRLN/13-455 AC A0A1B1MGK4.1
#=GS A0A248YPK9_9ACTN/10-449 AC A0A248YPK9.1
#=GS A0A1Q5CNM2_9ACTN/7-453 AC A0A1Q5CNM2.1
#=GS A0A6B3HFU2_9ACTN/1-141 AC A0A6B3HFU2.1
#=GS A0A5R8YTU6_9ACTN/17-457 AC A0A5R8YTU6.1
#=GS A0A7W0HUR9_9ACTN/11-453 AC A0A7W0HUR9.1
#=GS A0A4Y3R6S9_STRCI/2-448 AC A0A4Y3R6S9.1
#=GS A0A5N8XRE9_9ACTN/2-445 AC A0A5N8XRE9.1
#=GS A0A553ZRP3_9ACTN/13-451 AC A0A553ZRP3.1
#=GS A0A7Y7B2U1_STRMO/1-245 AC A0A7Y7B2U1.1
#=GS A0A1G9GYT6_9ACTN/4-447 AC A0A1G9GYT6.1
#=GS A0A7W5VAQ3_9ACTN/2-444 AC A0A7W5VAQ3.1
#=GS A0A1S2M003_9BACI/16-460 AC A0A1S2M003.1
#=GS A0A1M7QA12_9ACTN/19-454 AC A0A1M7QA12.1
#=GS A0A0N0T0Y0_9ACTN/7-452 AC A0A0N0T0Y0.1
#=GS A0A1Z2LC46_9ACTN/8-452 AC A0A1Z2LC46.1
#=GS A0A6G4WVY2_9ACTN/9-430 AC A0A6G4WVY2.1
#=GS A0A8J3MKD1_9ACTN/9-454 AC A0A8J3MKD1.1
#=GS F3NRX0_9ACTN/12-460 AC F3NRX0.1
#=GS A0A7K2XBN3_9ACTN/31-467 AC A0A7K2XBN3.1
#=GS A0A6F8YY70_9ACTN/28-476 AC A0A6F8YY70.1
#=GS A0A1I5QA24_9PSEU/1-428 AC A0A1I5QA24.1
#=GS A0A810NR75_9ACTN/9-454 AC A0A810NR75.1
#=GS A0A3A4A269_9ACTN/14-458 AC A0A3A4A269.1
#=GS A0A2P8B2Y3_9ACTN/7-453 AC A0A2P8B2Y3.1
#=GS A0A2R4TBB5_9ACTN/16-458 AC A0A2R4TBB5.1
#=GS A0A8J8HJ87_9ACTN/11-453 AC A0A8J8HJ87.1
#=GS A0A6B3HI97_9ACTN/1-87 AC A0A6B3HI97.1
#=GS A0A7H8IL69_9ACTN/18-459 AC A0A7H8IL69.1
#=GS D9T850_MICAI/7-451 AC D9T850.1
#=GS A0A7K1KX60_9ACTN/16-451 AC A0A7K1KX60.1
#=GS A0A2T0PYF1_9ACTN/9-457 AC A0A2T0PYF1.1
#=GS A0A4R6S5U9_LABRH/19-463 AC A0A4R6S5U9.1
#=GS A0A223S6Y5_9ACTN/8-454 AC A0A223S6Y5.1
#=GS A0A6B3G7M4_9ACTN/19-403 AC A0A6B3G7M4.1
#=GS A0A4P6TYT2_STRSO/1-396 AC A0A4P6TYT2.1
#=GS A0A0F2T392_STRR3/1-128 AC A0A0F2T392.1
#=GS A0A0F2TFI9_STRR3/2-314 AC A0A0F2TFI9.1
#=GS A0A8J4E5M7_9ACTN/465-911 AC A0A8J4E5M7.1
#=GS A0A6B3HJ68_9ACTN/6-90 AC A0A6B3HJ68.1
#=GS A0A8J3RVM4_9ACTN/2-444 AC A0A8J3RVM4.1
#=GS A0A7W9DPR0_9ACTN/13-458 AC A0A7W9DPR0.1
#=GS A0A429S6A1_9ACTN/2-449 AC A0A429S6A1.1
#=GS A0A2P8D158_9ACTN/20-462 AC A0A2P8D158.1
#=GS A0A7W7QZJ4_KITKI/10-448 AC A0A7W7QZJ4.1
#=GS A0A4V6NNI8_9PSEU/13-451 AC A0A4V6NNI8.1
#=GS A0A1H2U0J3_9PSEU/17-448 AC A0A1H2U0J3.1
#=GS A0A221W5A7_9PSEU/18-460 AC A0A221W5A7.1
#=GS A0A1Q5N6A1_9ACTN/18-458 AC A0A1Q5N6A1.1
#=GS A0A8J3CD22_9PSEU/19-455 AC A0A8J3CD22.1
#=GS A0A317DM36_9ACTN/9-455 AC A0A317DM36.1
#=GS V6KQQ1_STRRC/14-449 AC V6KQQ1.1
#=GS A0A6B3HXI2_9ACTN/2-94 AC A0A6B3HXI2.1
#=GS D2BFD8_STRRD/16-450 AC D2BFD8.1
#=GS A0A810L1F1_9ACTN/5-449 AC A0A810L1F1.1
#=GS A0A1G9W864_9ACTN/4-447 AC A0A1G9W864.1
#=GS A0A1A8ZJB8_9ACTN/9-456 AC A0A1A8ZJB8.1
#=GS A0A8J3VJ49_9ACTN/11-455 AC A0A8J3VJ49.1
#=GS A0A841CRZ5_9PSEU/13-462 AC A0A841CRZ5.1
#=GS A0A8J3MG67_9ACTN/10-447 AC A0A8J3MG67.1
#=GS A0A1C5BE87_9ACTN/7-452 AC A0A1C5BE87.1
#=GS A0A1R1SAM9_9ACTN/10-456 AC A0A1R1SAM9.1
#=GS A0A1H2TW55_9PSEU/3-445 AC A0A1H2TW55.1
#=GS A0A1V4AAB1_9ACTN/21-464 AC A0A1V4AAB1.1
#=GS A0A1E7KB52_9ACTN/2-454 AC A0A1E7KB52.1
#=GS A0A2U9PC88_STRAS/1-430 AC A0A2U9PC88.1
#=GS A0A120F8J4_9ACTN/1-401 AC A0A120F8J4.1
#=GS A0A6F8XVE6_9ACTN/10-458 AC A0A6F8XVE6.1
#=GS A0A542DFC7_AMYCI/2-431 AC A0A542DFC7.1
#=GS A0A0W7X1I3_9ACTN/19-454 AC A0A0W7X1I3.1
A0A1B1MGK4_STRLN/13-455 .............................qf--DAPYAEYAERLRRAMKTVAAS..R.AP.Q.DR.---FEPGYELPSPDSRLQRFFAAAAIRVSDLGSYRGRQLRLLDLMSNPATRTTKTLASLLMVARAVQHIRTTAEPVMIVTPSSANKATALRDAVARAIDCGLVTPDELQITVIVPAAARRKLWASPLSGSPELA.RRNPVLTHD.GSERSAVKELAQEFTDGWYASPPQGVRHRLWYTLDLDNYRVADTIRAFVEHDALP..APLPGGRLHAHAVSSAYGLLGHHFGHQML.....REEG..L..A..DDPPHYFLVQHLDTPDMVLSLHF.GSVSRENLPEYSRAP-GGLLTQS..A...DPRFPQTTKALDECLEPTFYTRAPVTSAEMNRLIRTHGGGGIVVSGHECLTRYREIRRLTARAGLTLPSDPAELREWSLVMAFTGVLYAIDRGLVA..EEDIVVHGSGSYSAADFVPLPMRLQRQVGDADE.VRTAVLES-l.........
A0A248YPK9_9ACTN/10-449 ..............................t-LDAALTHYHPRIQDALHRIRAQ..T.PP.-.--.APGFNPGYELPAPDERLNEFFAPSALRVAELGGYGSARLRLLDLMANPATRTTKTIASLVMVARAAQYIRRTGESILIVTPTSANKGTALRDAVFRAIDCGLVPADRLQIVTVAPRSSRHKLWCSGLDRDPTLA.RRNPIALYG.GDDAAGVKRIAAQFVAGHPGGPAAR-RPHVWYSLDINNYRVADAVRAFFELDFLP..PEPGVRRTHAHSVSSAYGLLGHHFGRQLL.....---G..A..P..QPAPAYFLVQHLGTPDMVLHLRH.GRVDPADRPGYEQDAGTGLFRQR..H...DPRFPAVTYDPAEELDPTFYTHNPPTSPQMDAVIAAQGGDGIVVSLHECMQRYPWIRHRLADAGVALPADPRRLREWSLVMALTGVCNGLDRGLVQ..ADEVVVHGSGCYGLDDFDPPPAGQIRPVRDVDG.LAAVIDRA-v.........
A0A1Q5CNM2_9ACTN/7-453 ..............................t-TRNLITDYYDVITSAVDQCGAV..P.GG.P.AG.TPGFAPGFDLPELTPAVREYYSAATASWSPLGEYGGHHLQLLDLTANPGTQTTKTFASMVIVARAVEYIRRTGTRLCIFTPTSGNKGVALRDSVARAYAARLVTPQQLSIVVLAPQSTRHKFRHDALAADPQSR.QVNPLLRYT.GSDPEGVKSLGRAFVDEYAATMHDKHGVTLWYTLDLKNYLVADAARAAFEADVAP..ASAARPRWHAHAVSSAFGLLGYNLGRDVLe...aAGKA..S..P..ADRPGFLLVQHLGTPDMVLSLRH.GSFERNNCPTYTLDESAGTWTQD..K...DPHFPAVTDDPTEVLDPTFYTHRPVTSPAMNALIERHGGDGIVVSRRECAQRYPAARDWLANAGLKLPADPEQLREWSVVMALTGVCNAIDRGLVP.vGHDIVVHGTGSYS-NDFAVADADA--EVSTVAD.VVAAVLN--rw........
A0A6B3HFU2_9ACTN/1-141 ..............................s-----------------------..-.--.-.--.--------------------------------------------------------------------------------------------------------------------------------------.---------.-------------------------------------------------------..-----------------------------.....----..-..-..--------------------LLK.GGTDRGLLPRYRRADPAGPWRQD..D...DPHFPATTDAPDERLDATFYTTAPPTSAQINPLIGRYGGTGVVVSRRECLDRYEEVAGLLAPLGHQLPEDPDDIREWSLVKAVTGAMVAVERGLIA.pGTDLIVHGSGFYTD-------------------.---------et........
A0A5R8YTU6_9ACTN/17-457 .............................at--RPALVRYYDELSRILAHAETR..ArSG.A.PD.GGAFTPGWSLPPLTPELEAFFAPSLITAHELEPYRDTRLTLLNLMHNPRTRTTKTFASLMIVARAVAHIRRTGEAVMIITPSSANKATALRDAVQRAHETGLAGEDELGIVCVVPSASRHKLWRSALVEDPRSR.RRNPLAVLD.SGEAGQVKTLARAVADEEAHAVFDRHGVRLWHSLDLANYAVADAARALFERDRLP..---AAARVHAHSVSSAFGLLGHFYGQQWH.....TGRE..W..P..GTGARYFLVQHLGTPDMVASLYH.GTFGYR--PEWTSH--DGLLTQH..A...DPHFPRVAYASDEDLDPTFYTRTPVTSPRMNEIIKTQGGGGIVVSLAECLDRYPSIRRLLEPAGVDLPADPRQVREWSLVMAVTGVLNAADRGLLD..LQDVLVHGSGSYHTGDYRPPEAHHLSSIGSLGD.LRDIVHAA-a.........
A0A7W0HUR9_9ACTN/11-453 .............................rh--ANLLVDFYDRLPRSIAACVDD..P.SP.V.RE.GAAFSPGFLLPELDGPMREFLSVATAAWQPMGQYGGHALTLLDLTRNPGTGTTKTFASLLIVARAVEYIRRYGEPVTIFSPTSANKGTALRDAVLRAIETGLVEPDQLRVVILAPASCAAKLRSSRLSTDPGLR.ALNPLLLYT.GEEPEDVKAIGRAFADKHGGEVD----GRLWYSLDLANYLVADTARAFFEHEADP..-IGATPRLHAHAVSSAFGMLGYHRGRAVLe...dDGLA..S..P..DTRPATLLVQHLGTPDMVLSLRH.DSFDRSHLPAFQPD-GRGLYAQS..A...DPRFPQVTYDPHEVLDPTFYTHRPATSPAMNDLIARFGGDGIVVSLAECVERYPRLRELLAPTGCALPADLRTLREWSLVMAMTGVLNAVDRGLVE.eGRDIVVHGSGSYGVADYTLLEQEATTPVASVED.VAEAVL---rp........
A0A4Y3R6S9_STRCI/2-448 ..............................l-LENALSHYYERLGPAMRRLFPE..T.AD.D.SG.-SAFSPGIQLPEPTPALRAYFAASDLAHLPLRAHRGRNLALLDLMRNPATMTTKTFASLVIVARAVRFIQDTGERVTIVTPSSANKAVALRDAVLRAITHGLVTAQQLNVVVVVPEAAVPKMRESELSTDPELR.ARNPVAVYA.GDEPGTVKDLAQGVVEEHGRHIRKAVGTNLWYTLQLENYLAADVVRAFAEAEFFA..PAAGTPRLHVHAVSSAYGLLGHARGRALL....eEEQP..G..R..GPAPRYFLVQHLGAPDMVLSLHH.GSPGPEHAPSYVYDPNSGLYGQQ..Q...DERFPALTHDPHEVLDSTFYTRKPVTSPRMNEIIRAQGGGGLVVSLHECLERYPLVRAVLGEAGVALPADPRAVREWSLVMAMTGVLNAIDRGLVD..ERDILVHGSGSYAAGDYVPLSVRDMWPVEDRAS.LGDVVVKA-s.........
A0A5N8XRE9_9ACTN/2-445 ..............................i-LENALARYYPQVQAALHALLGD..P.AA.D.DG.-PDFSPGAELPELTPAVRDYLSVSDMAYRPMPDYRGRSLSLLDLTRNPATMTTKTFASLVIVARAVRFIQDTGQRVTIVTPSSANKAVALRDAVLRSISCGLVTADQLNVVVVVPAGSVHKLRASELFTSPDLR.ARNPVAVYD.GADPEAVKAIARGAVNRYRGVLERELDSRLWYTLKLENYLAGDVVRAWAEAEHFA..PDADRPRLHVHAVSSAYGLLGHAYGRGMP.....-GAP..R..H..GAPPHYFLVQHLGAPDMVVSLYE.GG-DAGRVPDYVREPESGRYTQQ..A...NPRFPGVTFDPAEVLDTTFYSRRPATSPRMNALINGQGGGGIVVSLAECLERYAQVRDRLGDAGLLLPAHPASVLEWSLNMAVTGVLNAIDRGLVP..EHDIVVHGSGAYSRADFEGIPLRDLHRVDDEDA.LRDLVFKA-t.........
A0A553ZRP3_9ACTN/13-451 ..............................v-VHNALDRYFEEVRTAARKVGAE..R.AT.E.PE.-----IPLELAEKHPAFAAFTEVTDIGLTQVES----RTHILDLMRNPGARTTKTMASLLMIARAAAHIRRTGERVLLFTPTSGNKGTALRDAVARAYATGLASPDELRIVMLAPDASRSKLRDCALAGDQTLR.TANPVVLAR.VDQPADVKLLSSEVVERHAAEILDTTGFRIWYTLDLDNYRIADATRAFAEAELLP.iTADSAPRVHVHSVSSAFGLLGYHLGHRLLte.glPGRT..A..P..ARHPGFYLVQQLATADMVTSLLG.M-----KVPDYEHDEAAGVWRQD..A...APEFPAVTDNPKEVIDATFYTKEPPTRAKINEIVAHHGGGGIVVSRRECLERFDQVRALAANAGIAITADPTLIREWSLVKALTGVLVSRERGLLA.pDTEVVVHGSGYYSDELLPALREEHLTRVDTVND.LARAVLAA-a.........
A0A7Y7B2U1_STRMO/1-245 ..............................m-----------------------..-.--.-.--.--------------------------------------------------------------------------------------------------------------------------------------.---------.----------------------------HIWHTLDLDNYRAADTVRAFYEAEFLP..LPEGRIRWHSHAVSSAFGLFGHHLGTRLL....aAEPG..A..R..DDPPGYLLVQHLRTPDMVQDLYA.GAA----SPPYRRHPVSGLYVQN..A...NPVFPAAAFDPRESIDPTFYTERPATAPRMSALIREQGGSGIVVSLHECLGRYAQVRALVAQADVQLPADPRKLREWSLVMVVTGTLLAVERGLVR..ADEVVLHGSGSYDADDYTPLPADALRPAAQSAD.LAEVLHKA-a.........
A0A1G9GYT6_9ACTN/4-447 .............................ha--ANLLLDFYDRLPTSIAACVDG..T.EP.V.RG.DTGFSPGFLLPEPDAKLEKFFSVATARWQPLGSYSGHRLNLLDLTCNPATGTTKTFPSLLIVARAVEYIRRYGEAVTIFSPTSANKGVALRDAVLRAIDAGLAEPEQLRTVILAPRSCQAKLRSSRLSTDPALR.ALNPLLVYG.GAEPEQVKAIGRAFSEKYAGDLRAR-GENLWFSLELGNYLVADTARAFFEQQAAP..-AGAAPRLHAHAVSSAFGLLGYHRGRAVLe...gSGAV..S..Q..DSRPASLLVQHLGTPDMVLNLRN.GDFDRAGLPAYERD--GGLYRQS..A...DPRFPQVTYDPDEVLDPTFYTHRPATSPEMNGLIERFGGDGIVVSLAECVARYAELRELLAGSGCELPADFRQLREWSLVMAMTGVLNAIDRGLAD.pWDDVVVHGSGCYTAADYRPLEPEAMHEVSGVED.VAAVV----cg........
A0A7W5VAQ3_9ACTN/2-444 .............................ha--ANLLIDYYDRLPASIAACVDD..L.EP.V.RS.DIGFSPGYHLPALDADVERFLSVATARWEPLGEYGEHRLTLLDLTGNPATGTTKTFASLMIVARAVEYIRRYGEAVTIFSPTSANKGVALRDAVLRAIEAGLVRPDQLRTVILAPGSCLAKLRSSRLSTDPELR.ELNPMLVYN.GPEPEQVKALGRAFADKYAGDLRAN-GENLWYSLDLANYLVADTARAYFEHAASP..--VAGPRLHAHAVSSAFGLLGYHRGRDVLe...sSGAS..S..Q..EHRPASLLVQHLGTPDMVLNLRN.GSFDRAGLPQYALT--DGLYRQS..A...DPRFPAVTYDPDEVLDPTFYTHRPATSPSMNAIIERSGGDGIVVSLAECVARYPQVRELLAGTGCELPADFRTLREWSLVMAMTGVLNAVDRGLAD.dWRDVVVHGSGRYTSADYRPLEPEAMTEVATVED.VAAVVC---r.........
A0A1S2M003_9BACI/16-460 ..............................e-SNNLIERYYKGLQKAFENIDGG..N.K-.-.--.NNLFEPAFELPQLDEQMIKFFEVAQSSYSYLGDYKDKSIYLLNLMKNPGTNTTKTLASLLMVARAVNHIKKTGERILIFTPSSGNKAIALRDAVERAIKFGLVAKEELRIITLTPKNSSHKLRKSDLSENEELL.KLNPMFIYN.GEIPQDVKKIGSEFIKKYDRDIETKYGYRVWYSLDIRNYKVADSLRAFFDYEFFP.wKENQSKRLHAHAVSSAYGLLGYNYGRTIIk...nEGMK..I..H..EPNPGYLLVQHSETSDMVLSLLY.NDFSRSNYPKYIYDETDGMFKQK..Q...NSHFPYKTWRVIENLDGTFYTHNPPTSPEMNNLIHTNGGTGIVVSLSECLSRIGIIKQLLKGTDVSFPEDIRDLNEWSLVMAFTGVTNAIDRNLVD.aFDDIIIHGSGIYSEDDYLKVEKTQVKEIGNHKE.MFHAVF---e.........
A0A1M7QA12_9ACTN/19-454 ..............................a-VCRALVHYYDDLSRVLADTGQR..A.R-.-.--.TTGFAPAWQLPALTPALERFFEPGGISTRDLGSHHGTPLRFLNLMHNPRTRTTKTLASLMIVARAVAHIRRTGESVMIITPSSANKATALRDAVLRAHETGLVDTEQLRIACIVPATSCHKLWRSPLTDDDVLR.ARNPLAVLD.AAQPLHVKELARSVADREADTLWARHGVRLWHTMDLNNYAVADTARALFERDHLP..---AVPRVHAHAVSSAFGLLGHFYGQQQH.....TGRE..W..P..DTGARYFLVQHLGTPDMVSSYYH.GTFDYR--PRWTYR--DGLHVQD..S...DPRFPQRTFAPHEQLDATFYTHAPATSERMNEIIRRQGGGGIVVSLAECVDRYPLVRDLLRPAGVELPSDPRQLREWSLVMAMTGVLNALDRGLLD..ETEVLVHGSGSYDAGDYQAPQAHQLRPVTGYED.LRDLVHAA-a.........
A0A0N0T0Y0_9ACTN/7-452 .............................ae--RNLILDYYERLPQAVAALVDD..P.AP.V.TE.PGAFSPGFALPEPDAGVRDFFEPARAQWRELGKYGSHRLVMLDLAGNPGTHTTKTFPSLLIVARAVEYIRRTGEPVMIFTPTSANKGTALRDAVARALAAGLATPDQLRIATLAPASGRSKLRAGSLTDDAELR.ARNPLMVYD.GERAEDVKTLARQFTDAHAADLKRRHGLNLWFSLDLRNYLVADTARAFFEQDADP..TDAAGPRLHAHAVSSAFGLLGYHAGRDVLe...aAGEA..R..P..ASRPASLLVQHLGTPDMVLSLRR.GSFDRAGLPRYERGD-DGLWRQR..T...DPNFPGVADEVDEILDPTFYTHRPATSPAMNAIIARHGGDGIVVSRHECLERYPALRELVADHARPLPDDPRALREWSLVMALTGVCNAVDRGLVE.aGRDVVVHGSGWYADDDVRTPEESALVPVSTVED.IAAAL----l.........
A0A1Z2LC46_9ACTN/8-452 ..............................v-LDNALTHYYDRVQTALHRVAES..R.RA.D.AR.-KDFSPGPLLTPPTDRFRAYVSVSGLAATEAGEHHGVRLTLLDLMRNPGTRTTKTMASLVIVARAAHHVRETGERLMLLTPSSANKATALRDAVLRAVDHGLVTRDGLRVACVVPEESAHKVWRSRLSDDPELR.RRNPVLVHA.GSG-AAVKALAGEAAGDAAARIRHLTGVRVWHTLDLDNYRAADTVRAYFEDEYLP..PRDGRVRWHSHAVSSAFGLLGHHLGTRLLar.ekIGSG..A..A..RPSPGYLLVQHLATPDMVLGLHR.DG----GLPAYGLDRGSGLFTQA..A...NPRFPAAADDPSESIDPTFYTKTPATAPAMSEIVRTQGGGGLVVSRHECLARYARVRALVAPAGIQLPSDPARLREWSLVMVVTGTLLAVERGLVE..ADEVVVHGSGSYTADDFAPLPAAALRPVGSVTD.VADALHAA-a.........
A0A6G4WVY2_9ACTN/9-430 .......................vrywdtvr-----------------------..-.--.-.--.--ETFPGGGLPPLDDRLAGCLSAAAIAVHELPDYRGTRLRLLDLARNPEAPSVKSAGALVTVAHAAARVRATGQPVTLLAPSSGNGATALRDAVLRAHRYGLAAPDRLRAVCLVPARSRYKLRRSPLCE-PPLG.RRNPVVVYH.GSDPGGVAGLARAYREQYARELRATYGGALWLVSGRTGDRAAGAARALLERDELP..EPGPYGRVHAQAVDSGAGLLGHHDGTLRL.....PG--..-..G..HPPPRYLLVQHLNTPDLVLHALF.GSCSRAPMPRYAYDPERRLHRQE..A...DPRFPGAARSPDEVLDPTFFTRVPDTASELSAVVRAGGGGGCVVSAQECLDRYTTVRALLGAAGIRLPAAPDEVREWALPMALTGVLCAVDRGLLGpgTPEVLVHGTGCAGVRDSAPLPDSGLRYADSVWE.LDTVVAQA-l.........
A0A8J3MKD1_9ACTN/9-454 ..............................v-TRNLIVDYYEVIASAAARLGAG..P.GG.P.AG.TATFGPGFDLPELSAQWREFFGAATATWRELGAYGGHGLQFMDLTGNPGTNTTKTFPSMLIVARAVEHIRRTGESICIFTPTSANKGIALRDAVGRAIAAGLVTPEQLRVVVLAPGSTRHKFRRDPLSADPALR.AANPLLRFT.GDQSEGVKALGRAFVDAYAQEAYNKHGTALWFSLALPNYLVADAARAAFELDAAQ..AVAAAPRWHAHAVSSAFGLLGYNLGRDLLe...aSGRA..D..G..SPRPGFLLVQHLGTPDMVLNLRH.GTFSRDRLPAYRRD-AAGVWSQD..A...DPHFPAVTDDPDEVLDPTFYTHQPVTSPAMNDLIAAYGGDGITVSRRECLQRYPQLREWLRNTGCELPADPADLREWSIVMALTGVLNAIDRGLVP.aGREIVVHGSGSYRDDHYAVYEPDA--EVSTVEE.IASAV----lgg.......
F3NRX0_9ACTN/12-460 .............................is--RNPVLDHYHRLPDIVSACAQE..R.AG.R.PD.PEAFRPDFDFPPLDARMREFLAPAALSWCPLPDLDGRRMRLLDLTGNPGTRTTKTLASLLIVARAVAHVRRTGVPVVLVTPTSANKGTALRDAVLRALDLGLAEPHQLRVVTVCPAVCRDKLRRSRLATDPELR.ALNPVLVHT.GQQAEDVKPLTRAFVHAHAAEWARRTGGRLWFSLDLANYMVADTTRALFEHDVDP..IPPGEVRVHAHAVSSAFGLLGYHTGREILe...aTGEA..A..G..GPRPESFLVQHLHIPDMVLSQRF.GSFDRRNAPAYEWDERAELYRQD..R...EPCFPYVTDTPNEILDPTFYTHRPGTSERMNEIIGKFGGGGIVVSRRECLEHYEAIARDLSEAGIPLPDDPRRLAEWSLLMAMTGVREGVRRGLIG.pDRTIVVHASGTYAHGEYEPLREGDYQWVHDEAD.VAAAV----gva.......
A0A7K2XBN3_9ACTN/31-467 ............................vcp---AALTRYDRELRQILAAAEDA..A.ET.P.A-.--GFSPRWELPEPSPSLETFFAPSTMSAHHLGERAGTRLGLLNLMHNPRTRTTKTFASLVIVARAVAHVRRTGEPVMIVTPSSANKATALRDAVLRAHEAGLATERELRIACVVPSVSAAKLWDSPLAQDAERR.RAHPVAVSH.GGGSAQVKELARAVVDAEADAVFAAHGVRLWHTMDLGNYMVADAVRALFERDNLP..---REPRVHAHAVSSAFGLLGHFHGQQWH.....TGRQ..W..P..AEGAGYFLVQHLGTPDMVASLHH.GSFDHR--PAWEAR--DGLLVQS..E...DPRFPFAAHAADEQLDPTFYTHTPATSPRMNEIIRRQGGGGIVVSLVECVERYPAIRELLAPHGVVLPSDPRRLREWSLVMALTGVFNAVDRGLLT..DPEVLVHASGSYHSGDFRPVRDEHLRPVDSLDD.LRALVREA-a.........
A0A6F8YY70_9ACTN/28-476 ............................rsg---NLLVDFYDRLPEVIARCVPD..P.SP.V.AD.PVVFSPGFALPALDDAVRGFLSVATAQWQPVGEYRGHRVTLLDLTGNPGTNTTKTYASLLIVARAVEHIRRTGRPVMIVSPTSANKGVALRDAVLRALDAGLVGPEQLRVVTLAPQTGRHKLRASRLSTDPALR.ALNPQLLYM.GKEPEAVKSLAREYVREHAGTLHRTRGLDMWFSLELSNYTVADASRALFEQRVDP.iGAAARPRVHAHAVSSAFGLLGYHAGRSLLe...dTGEA..S..A..ATRPASLLVQHLATPDMVLSLRA.AAGAAPSLPAYPLDPASGLFRRA.gD...DPRFPAVTYDPGEVLDATFYTHRPVTSGPMNEIIARFGGDGIVVSLAECVARYPYLRTWLGAALPLLPADFRTLREWSTVMAFTGVTNAIDRGLVA.pGREVVVHGTGCYADGDLEPLCGDGLVEVADVAD.IAAAV----r.........
A0A1I5QA24_9PSEU/1-428 ............................mna------LRYENQLRSAVAEMGTR..G.RA.S.--.-ADFEPAFELPEPTPELAEYFAAANLRFAELGTAGRTRLTLLDLMGNPATRTVKTLASLVIVARAVRHIRTTGERVLILTPSSANKATALRDAVLRARAHGLVRHDELRIVTVVPDVARPKLWSSALDDDPT--.--SPMCVLD.PANPEHVKTVAVEAMTGCAEDLYAHWGIRLWHTLDLANYQCADTVRAFAEHAELP..AAPGTTRVHAHAVSSAFGLLGHHYGTTLL.....----..P..P..SEPPRYLLVQHLATPDMVCGLYG.IE-----PPEYRFDPVSGLFHQD..S...EPHYPAVTYDPAEKLESTFYTRKPVTSPAMNELIRTYGGGGVVVSLRECLDRYGQIATLLANAGVDLPADPRSLREWSLVLAMTGVLNAIDRGLLD..ADEVVVHGSGSYSAADYTPIPERSLRRVGDAAD.LRREIFTA-a.........
A0A810NR75_9ACTN/9-454 ..............................v-TRNLIVDYYDVISSAVARIGAG..P.GD.A.AG.TPGFAPGFDLPELSADVRQFFAVATATWRELGAYGGHELRFMDLTGNPGTHTTKTFPSMLIVARAVEHIRRTGERVCIFTPTSANKGIALRDAVGRAVAAGLVTPDQLRVVVLAPGSTRHKFRHDPLAADPALR.AANPLLRFT.GDEPEGVKALGRAFVDAYAREAYDKHGTALWFSLALPNYLVADAARAAFELDAAP..ATAAAPRWHAHAVSSAFGLLGYNLGRDVLe...dSGRA..D..G..SPRPGFLLVQHLGTPDMVLSLRH.GTFSRDRLPAYRRD-AAGVWRQD..A...DPHFPAVTDDPDEVLDPTFYTHRPVTSPAMNDLIGRYGGDGVTVSRRECLERYPMLRERLRGTPCELPADPADLREWSIVMALTGVLNAIDRGLVP.tGQELVVHGSGCYRGDDYTVCEPDA--EVSTVEE.IAAAV----lgg.......
A0A3A4A269_9ACTN/14-458 .............................rt--ANLLADFYDRLPRAIAACVDD..P.AP.V.KD.GSAFSPGFLLPELDDRMREYLSVATASWQGLGTYGGHRLSLLDLTGNPGTGTTKTFASLLIVARAVEYIRRHGERVTIFSPTSANKGTALRDAVLRAIEAGLVEPGQLRVVVLAPESCLAKLRSSRLSTDPALR.ELNPLLVYT.GEHAEDVKAIGRRFADKHIGDFAAM-GDNLWYSLELANYLVADTARAFFEHAADP..-AGERPRLHAHAVSSAFGLLGYHRGRAVLe...eEGAA..D..P..ATRPASLLVQHLGTPDMVLNLRH.GDFDRAAIPAYALG-EDGLYAQS..A...DPRFPQVTYDPDEVLDPTFYTHRPATSPAMNDLIARFGGDGIVVSLAECVARYPRLRAMLAGTGCELPADPRTLREWSLVMAMTGVLNAVDRGLVD.eGRDIVVHGSGCYTAAGYRPVEDAAITRVGTVED.VAEAV----ig........
A0A2P8B2Y3_9ACTN/7-453 ..............................t-TRNLITDYYDVIASAVDQCGAV..P.GG.P.AG.TPGFAPGFDLPELTPAVREYYAAATASWSPLGEYGGHNLQLLDLTANPGTQTTKTFASMVIVARAVEYIRRTGTRLCIFTPTSGNKGVALRDAVARTYAAGLVTPEQLSIVVLAPQSTRHKFRHDALAADPRSR.QVNPLLRYT.GSDPEGVKALGRAFVDEYAATMQDKHGVTLWYTLDLKNYLVADAARAAFEADVAP..ASAARPRWHAHAVSSAFGLLGYNLGRDVLe...aAGQA..S..T..ADRPGFLLVQHLGTPDMVLNLRH.GSFERNNCPAYTLDEGVGAWTQD..K...DPHFPAVTDDPAEVLDPTFYTHRPVTSPAMNALIERHGGDGIVVSRRECAQRYPVARDWLANAGLNLPADPEQLREWSIVMALTGVCNAIDRGLVP.aGHDIVVHGTGSYA-NDFAVAVADA--EVSTVAD.IVAAVLS--kw........
A0A2R4TBB5_9ACTN/16-458 ............................avv---PALSRYWETVGRAVRAMHEH..R.SL.P.GD.---FTPGAELPPLDGPVRRYLEASEAAVARLPDYRETRMRLLDLRRNPGTRTTKTFGSLLMVARAVAYIRRTGEPVTLLTPSSGNKATALRDAVLRAHRAGLADRDQLRIVSVVPERSRAKLWDSPLSSDPELR.RRNPVVTYP.GPDPAGVKELARAYYDEYGDLLRTRYGSALWYTLDIANYQAADTVRALMEAELMP..PPPAHGRVHAHAVSSAFGLLGHHYGTSLT.....-GGG..E..E..RMPPRYFLVQHLSTPDMVLDLLH.GDASRERMPRFTLETSTGLYHQS..S...DPHFPRTTHHPEEVIDPTFYTRAPMTSRVMTPLIKANGGGGVVVSLHECLARYPQIREMLRPAGVELPHDPRTVREWSLVMVFTGVMEAVDRGLLT..EPEVLVHGSGSYAETDFSPIPAQRLQRAADTAE.LHPVVSRAM..........
A0A8J8HJ87_9ACTN/11-453 .............................rh--ANLLVDFYDRLPRSIAACVDD..P.SP.V.RE.GAAFSPGFLLPELDDSMREFLSVATAAWQPMGQYGGHALTLLDLTRNPGTGTTKTFASLLIVARAVEYIRRYGEPVTIFSPTSANKGTALRDAVLRAIETGLVEPEQLRVVILAPASCAAKLRSSRLSTDPGLR.ALNPLLLYT.GQEPEDVKAIGRAFADKHGGEVD----GRLWYSLDLANYLVADTARAFFEHEADP..-VGDTPRLHAHAVSSAFGMLGYHRGRAVLe...dDGLA..S..P..ATRPATLLVQHLGTPDMVLSLRH.DSFDRSHLPSFQPD-GRGLYAQS..A...DPRFPQVTYDPHEVLDPTFYTHRPATSPAMNDLIGRFGGDGIVVSLAECVERYPRLRELLAPTGCALPADLRTLREWSLVMAMTGVLNAVDRGLVE.eGRDIVVHGSGSYGVADYTLLEQEATIPVASVED.VAEAVL---rp........
A0A6B3HI97_9ACTN/1-87 ...............................-----------------------..-.--.-.--.---------------------------------------------------TTKTFASLHIVARAVQHIRQTGEPLLLTTPTSGNKGTALRDAVARAYAAGLATPEELRVLTVAPAHSRSKLRDGPLSADPALR.AANP-----.-------------------------------------------------------..-----------------------------.....----..-..-..-----------------------.-----------------------..-...------------------------------------------------------------------------------------------------..---------------------------------.---------..........
A0A7H8IL69_9ACTN/18-459 ............................esp---SLLTRYYRAVAECAARYGTV..P.A-.-.--.DGEFEPSMRLPEMDARVAEFLSPATAGLYDLGDHRGLPLRLLDLRQNPHTQTTKTFASLIIVARAVRHIQETGEPVVLFSPSSGNKAVALRDAVARALTAGLVQPDQLRVVTLTPAQTTGKLRSSILSEDAELR.ALNPVFVLD.DAPPETVKQVGREFKSLFA--VSGHDGFRLWHSLRLENYRVADIVRALYDYEFGQ.aGRTRLRTVHAHAVSSAFGLLGYQSGIDLL.....KELG..H..Q..VADPSFLLVQHMATRDMVLHTLN.GSFDPANTPEYTKGP-DGVWVQD..A...SPHFPRRTWSPRETLEHTFYTHEPPTAPEMSGLIAAHGGTGIVVSLKECMDRYGECRELLRKSPVPLPSDPRRLTEWSLVMAVTGVLNAIDRGLLP.dADGVTVHASGTYGRDDYTPLPDAWINHVDSAGQ.ILDTVL---gkv.......
D9T850_MICAI/7-451 ..............................a-TRNMITDYYDVIASAVRRCGAV..P.GD.A.PG.TPGFAPGFDLPELTLAVREFYAAATVSWSPLGHYGGHDLTMLDLTANPGTRTTKTFASMVIVARAVEHIRRTGERLCIVTPTSGNKGVALRDSVARAYAAGLVTPEQLSIVVLAPAATRHKFRHDALAADPATR.AVNPLLRYT.GADPEGVKALGRAFVDEYAATAYDKHGVTLWYTLDLRNYLVADAARAAFEADVSP..--ATGSRWHAHAVSSAFGLLGYNLGRDVLe...aTGDA..D..P..ADRPGFLLVQHLGTPDMVLNLRH.GSFERDHCPAYTLDENRGVWTQD..A...DLRFPAVTDDPAEVLDPTFYTHRPVTSPAMNALVRRHGGDGIVVSRRECVRRYPVARQWLADAGLTLPEDPARLREWSILMALTGVCNAVDRGLVP.aGHEIVVHGTGSYC-DDFRIAEPDA--EVSTLAD.VVAAVL---dqr.......
A0A7K1KX60_9ACTN/16-451 .............................vi--HNALSRFHDEIRAAARAVAAE..R.D-.-.--.---VQPVVPL-EPADRFTEFTDATDIGLTRVEPHT----YVLDLMRNPGARTTKTMASLLMVARAAGHTRRTGERVMILTPTSGNKGTALRDAVARAYATGIATPADLRVVTVNPEASRGKLRDCPLTADAGLR.AANPVALAR.VAEPGDVKAVTARVAREEAGALFEATGFRLWPTLDLDNYRIADAARAFAEAELLP.lTEDSPPRLHAHAVSSAFGLLGYHLGHEMLar.glPGRA..V..P..ARHPGFWLVQQLATPDMVTAVLG.A-----DVPDYACDPGGAVWRQE..G...APHFPAETDDPREVVDSTFYTRAPATIPQVNAIIGRHGGGGGIVSRRECLARFDRVRALAAEAGIAIGADPAEIREWSLVKALTGVLVARERGLIA.pGTDVVVHASGHYTDASLAPARDEHLTPIGGADD.LARLVRAA-a.........
A0A2T0PYF1_9ACTN/9-457 .............................ai--ANLLLDFYQDLPEVIGARVAD..T.AP.V.DD.DSAFSPGFLLPEPDEAVRGYLSAATAGWHELDGYGGHRISLLDLARNPGTHTTKTFASLLIVARAAEYCRRTGERVMILSPTSANKGVALRDAVLRAVDAGLVEPDMLRVAVIAPRSCAGKLRSSRLSTDPALS.ALNPVLVYP.GSEPEEVKAVGRAFLAEHAGRLRRRHGLRTWFTLALDNYVVADAARAFFERRAAP.vEEAARPRLHAHAVSSAFGLLGYHHGRAVLe...qRGDA..D..P..ARRPASLLVQHLATPDMVLHHKY.RDFSRDRLPAYTRDPRTGALAQD..V...DPHFPLTAGSLDEVLEPTFYSHRPATSEAMSAIIDRHGGSGIVVSRAECLERYPLVRALMTSAPRPLPADHRQLREWSLVMAFTGVMNAIDRGLVS.aESDVVVHGSGYYGTHEFEPIAEASLLPVRTADD.VADAV----gr........
A0A4R6S5U9_LABRH/19-463 ..............................a-TRNLILDYYDRLPAVIDRYVPD..V.AP.D.ER.VEAFNPGFALPELDDGVRDYFDVAGADLHELGEYGDTKLMLLDLMRNPGTNTTKTLPSLLIVARAVEYIRRTGHPVLIFSPTSANKGTALRDAVWRALDAGLVTREQLRIVTLAPKSCVDKLRSGPLSADEELR.ALNPVLVYD.GPQPEDVKVLGKQFAQEHAAWFAGRHGSRMWFSLELRNYVIADATRAFLEQDVSP..--AHPARVQAHAVSSAFGLLGYSLGREVL.....EEQKlaK..V..DDRAGYLLVQHLGTPDMVLSLHH.GSHDRSTLPAYARDDTTGLYTQQ..Q...SPHFPAVTFDPGEVLDPTFYTRAPVTSAEMNPLIERFGGAGVVVSLAECLQRYPLLRPWYENTSRPLPSDFRTMREWSLVMATTGVLNALDRGLIP.gGGEVVVHGSGSYTTADYQPLERAAMTTVRTVDD.IVAA-----lt........
A0A223S6Y5_9ACTN/8-454 ..............................t-TQNAIIDNYEFLEAALRRVGSK..K.SG.P.LD.-TAFFPEFKVPRMDARLAEFFGAADVSVTRLGSYRGKDVTFLNLMRNPRTRTTWTLPSHVMVARAIRHIWSTGEPITLLTPSSANKGTALRDAVLRAIECGLVSADDLQMVTLIPESARDKLWSSSLNEDSGLR.ARNPVAIYS.GDEPSNVKKIAREFVDQYGKEFTARTGRRLWYTLDIDNYRAVDALRAAVERRLAP..--TAGRRIHVHAVSSAYGLLGHHFGRSLLs...gTGGE..A..G..DPPPSYFLVQHLGRPEMVLNLYH.GDFSNEHVPDYRLDGEAGLYRQD..Q...EAHFPHVADDPEEFLDITFYAYQAATSSDMNDIIAKQGGGGIVVSRRECLDRYNEITKLLAPAGITLPSDPARLRDWSLVMAAAGLLLGVDRRLID.aEDDVLLHGSGSYTQDDFTPIPGHHLHGVDDAQR.LRTVVFES-a.........
A0A6B3G7M4_9ACTN/19-403 ..............................t-VCRALLRYYDDLSGILTATGQG..S.P-.-.--.TSGFAPEWRLPALSPAVERFFEAGGISAQDLGRYHGTPLRFLNLMHNPRTRTTKTLASLMIVGRAVAHIQRTGESIMIITPSSANKATALRDAVLRAQETGLVGAEQLRIVCVVPEASSHKLWRSPLTDDDALR.ARNPLAVLD.STQPLHVKELARACADQEADALFSRHKLRLWHTMDLSNYAVADTARALFERDHLP..---AAPRVHAHAVSSAFGLLGHFYGQQQS.....TGRE..W..P..DTGARYFLVQHLGTSDMVSSYYH.GRFDYR--PQWQTR--DGLHVQD..S...DPHFPERTFAPEEQLETTFYTRAPATAERMNQIIGRQGGGGIVVSLAECLDRYPLIRDLLAPVHVHLPSDPRQVREWSLVMAVTGVL---------..---------------------------------.---------..........
A0A4P6TYT2_STRSO/1-396 ..............................m-----------------------..-.--.-.--.--------------------------SVAPLPSYDGRNLALLDLMSNPATMTTKTFASLVIVARAVRFIQDTGERITIVTPSSANKAIALRDAVLRAVNCGLVGADQLNIVVLVPEGSVAKLRRTGLYSDPYLR.TRNPIAVLGrDRTPGAVKDIARGFVDSHGEELTRDHKTHLWYTLQLENYLAADIVRALSEAEFFP..ATADRPRLHAHAVSSAYGLLGHAYGRTRL....pEADR..A..G..TPDPRYFLVQHLGAPDMVLSLYNdGSTDPGNMPAYSLQPETGLYTQE..R...DPHFPAFTYDPHEALDPTFYTRNPPTSPRMNELIQGQGGGGLVVSLAECLQRYAQVRNILGEAKMRLPADPRALREWSLVMAVTGVLNGIDRGLIG..EQDILVHGSGSYSASDFDSVGIHDTHRVEDVAA.LHQLVLTA-v.........
A0A0F2T392_STRR3/1-128 ...............................-----------------------..-.--.-.--.--------------------------------------------------------------------------------------------------------------------------------------.---------.-------------------------------------------------------..-----------------------------.....----..-..-..-----------------------.-----------------------..-...----------PHEDLDPTFYTRNPPTSARMNHLIHTQGGGGIVVSLAECLQRYAQARDLLARAAIDLPANPTAVREWSLVMAVVGLLNAVDRGLVP..EDDILIHASGHYHADQVGQLSARDLHDTPDTEA.LRRLVLG--ac........
A0A0F2TFI9_STRR3/2-314 .............................li--ENALATYYGDIQHALRDLFATtpE.TT.P.NT.GGDFTPGTELPHLSVAMRDFLAPSGLAHAPMGHYAGKQLALLDLTRNPATGTTKTYPSLVIVARAIRFIQDTGQRVTIVTPSSANKAIALRDAVLRAITCGLVGADQLNVITVVPAASVPKLRSSELFTDPALR.ARNPIAVHH.GPTPGAVKTIARALVDDHRTPIEQATKTNLWYTLQLENYLAADTVRALAEHQHFP..PAPDRPRLHVHAVSSAYGLLGHAYGRTLL....dPTAR..A..A..TPEPHYLLVQHLGAPDMVLSLYHhGVVDPAHAPAYTRDPATGLYTQH..-...------------------------------------------------------------------------------------------------..---------------------------------.---------t.........
A0A8J4E5M7_9ACTN/465-911 ..............................a-TANLLLDFYDELPRAIAACVDD..P.TP.N.RD.PKAFSPGFMLPEPGDDVREYLDVATASWRPTTVYSGHQLTLLDLTNNPGTRTTKTFPSLLIVARAVEYIRRTGESIMIFSPTSANKGTGLRDAVLRAVTAGLVRPDQLRIVTLAPASCRGKLRQSRLAEDPQLR.ALNPLLLYT.GDEPEAVKPLGREFVDTYADK---LAGVNVWYSLELRNYLVADTARAFFEQRVDP.tDAAPRPRWHAHAVSSAFGLLGYHTGRKILe...eTGRA..D..P..DTRPGSLLVQHLGTPDMVLNLCH.GDFDRANVPSYRVDEDSLLFRRD.gD...DPHFPAVTYTPDEVLDPTFYTHRPVTSTAMNEIIARHGGDGIVVSLAECITRYPVLRSWLAGSARPLPADFRDLREWSTVMAFTGVLNAIDRGLVP.dGHDVVVHGSGSYTTADFDPLDAAAITPVRTVRD.IADAL----ls........
A0A6B3HJ68_9ACTN/6-90 tetvvaaamaryqpmlratpellglshtgpv-----------------------..-.--.-.--.------GFRLPEADARLDHFHEASDIALRSAGEWRGHRVSLLDLTLNPGTRTTKTFASL---------------------------------------------------------------------------.---------.-------------------------------------------------------..-----------------------------.....----..-..-..-----------------------.-----------------------..-...------------------------------------------------------------------------------------------------..---------------------------------.---------h.........
A0A8J3RVM4_9ACTN/2-444 .............................ha--ANLLIDYYDRLPASIAACVDD..L.EP.A.RS.DIGFSPGYHLPALDADVERFLSVATARWEPLGEYGEHRLTLLDLTGNPATGTTKTFASLMIVARAVEYIRRYGEAITIFSPTSANKGVALRDAVLRAIEAGLVRPDQLRTVILAPGSCLAKLRSSRLSTDPALR.ELNPMLVYD.GPEPERVKALGRAFADKYAGDLRAN-GENLWYSLDLANYLVADTARAYFEHAASP..--VAGPRLHAHAVSSAFGLLGYHRGRDVL.....EESG..AsdP..EHRPASLLVQHLGTPDMVLNLRN.GSFDRAGLPEYAPA--DGLYRQS..A...DPRFPAVTYDPDEVLDPTFYTHRPATSPSMNAIIERSGGDGIVVSLAECVARYPQVRGLLAGTGCELPADFRQLREWSLVMALTGVLNAVDRGLAD.dWRDVVVHGSGRYTSADYAPLEPEAMTEVATVED.VAAAVC---r.........
A0A7W9DPR0_9ACTN/13-458 .............................rs--ANLLLDFFDRLGEAIPAIAGH..V.DPvR.DG.DAAFSPGFLLPEPDEPLRRFLSAATVRWHRLAGYGGHRLHLMDLTGNPGTGTTKTFASLLIVARAVAYIRRYGENVTIFSPTSANKGTALRDAVLRAIEAGLVEPEQLRVVIVAPRSCQAKLRASRLSEDPELR.ALNPVFLYT.GPEPEHVKALGAEFVERYGAEAGKRLDTRLWYSLELRNYMVADAARAFFEREALP..-DATARRVHAHAVSSAFGLLGYHQGRAALe...rAGLA..R..P..EDRPASLLVQHLGTPDMVLNLVH.GDFGRENVPAYTTA-ADGLYHQS..A...DPRFPRVTADPGEVLDPTFYTHRPATSPAMNELIRRYGGDGIVVSLAECVERYPLLRRLLDGTGCALPADLRELQEWSLVMALTGVMNAVDRGLVEgaGHDIVVHGSGAYARADYRPLRYF--TEVEE---.---------pgdiatalyg
A0A429S6A1_9ACTN/2-449 ..............................l-LDNALVQYYEEIRAALRDLLGD..Q.ER.Q.DT.-GGFTPGVELPDLTPAVRAFLSASGLAHAEMPSYRGRRLALLDLARNPATMTTKTFASLVIVARAVRFIQDTGQRVTIVTPSSANKAIALRDAVLRALRAGLVDADQLNVVVVVPEGSVAKLRTSELFTDPGLR.ARNPVAVYG.GPVPGTVKSLALQLVDQFRDVLEKAGETNLWYTLQLENYLAADVVRALAEAERFP..AAPGEARLHVHAVSSAYGLLGHAYGRSRL....pADVR..S..R..TTPPHYLLVQHLGAPDMVLSLYNdGSTDTAALPAYDLDPASGMFRQE..S...DPRYPAQTFDPRETLDPTFYTRNPPTSPRMNELIRTQGGGGIVVSLAECLSRYGQIRAMLGEVGVRLPANPTELREWSLTMAMTGMLNAVDRGLVS..EPDILVHGSGSYSASDYGHLTVRDLHPVTTAED.LQHVVLDA-m.........
A0A2P8D158_9ACTN/20-462 ..............................s-SESLITRYYQGIQLASAELEKK..R.T-.-.--.GNGFCPPFEYPDLTDDWEQYFSPAGASWEHLDDYGGKRVVLLDLMKNPEVRTTKTTASLLMVARAVHHIRRTGESILIFCPSSGNKAVALRDAVARAIDLGLAAPDELRIATFTPARTTYKFRRNLLTESEELR.RLNPILVLD.GPQPAAVKELGQEFVRA--AQFGGPRTCRVWYTLDIANYKVADACRAFFEYEFGG.aDPAHRRRLHAHAVSSAYGLLGYQHGLGVL.....ARLG..L..P..IAQPGFLLVQHLATSDMVAHHLS.GGAGFEMDIDYQPDPETGLLRQQ..A...SPHFPYATWSLGEDLEPTFYTKTPVTSPEMTGLIAAHGGTGIVVSLYECLTRYSLARQMLALSGCELPADPRTLAEWSLVMVLTGMTNAADRALID.qFNEVVVHGSGMYPHHSEHAVSRAQTVEVGCLAD.MLRAVP---gtq.......
A0A7W7QZJ4_KITKI/10-448 ..............................v-VDSALTRYGAEIRRALSELAPP..V.G-.-.--.--EFGPGNELPPDSEKLSRYFAASSLAFADLGSYRGKRIRLLDLMRNPRTRTTKTFASLPIVARAVEHIRRTGERVMLLSPSSGNKATALRDAVLRAHESELATAEQLSITVVVPGASRDKLWSSPLAEDELLH.SRNPVAVYD.GAERADVKPLARALVDGYGETLRERCGVNLWYTLDINNYKAADIVRAFAERDFLP..--PAEGRLHVHAVSSAYGLLGHDLGARRL.....AAAG..L..G..KPSAHYFLVQHLDTPDMVLSLYF.GSHSRENLPTYHYDEQTGLHHQD..S...DPHFPATAYEVGENLDPTFYTRTPPTSAEINPIIDSRGGGGIVVSLAECLERYPRLRAMLAPARIVLPADPRELREWSIVMAMTGLLNGIDRGLVP..EDDILVHGSGSYHQGDFTPLAADRLTPVADVAE.LAEVALAA-a.........
A0A4V6NNI8_9PSEU/13-451 ............................vtg---NLLADFYDLLPRAAEPSMLD..P.AV.A.DP.-AAFSPGFALPELDSDVLGFLSVATARWRPLGEYAGHRMTMLDLTGNPGTGTTKTFASLLIVARAVAYIRRTGEPVVIFSPTSANKGVALRDAVLRAIDAGLVTPSQLRVVVLAPMSCAHKMRASRLSTDEYLR.ALNPLLLYS.GPKAEDVKALGREFVDRHAAALRRDRGINLWFTLELRNYIVADTARAFFEHQVAP..-VGDTPRVHAHAVSSAFGLLGYHRGREVLe...dMGSV..D..R..ASRPASLLVQHLGAPDMVVNLRH.GDFAETRRPEYRLDPETGLYRQS..A...DIRFPQVTYDPAEVLDPTFYTRAPATSPAMNDLITRHGGDGVVVSLAECVARYPALRLMVD----HLPADFRELREWSLVMALTGVLNAIDRGLVE.aGREVVVHGSGCYTATDYELPESTV--PVRTVDD.IAGV-----la........
A0A1H2U0J3_9PSEU/17-448 ...........................gstn----VLIRYYEEITGA------Q..P.IP.-.-P.GEGFEPGFAFPALDDRVAAFLEPATVTHHVLDEIAGVRLRLLDLRRNPATQTTKTLASLLLVARAVEHIRRTGEPILIFSPSSGNKAVALRDAVERALSNGLAEPHQLRIVTLTPASTTAKLRASRLSDDPELR.RLNPVVVLR.GSPPEAVKAIGAEFVREYRRGA--QRAGQVWATLRLDNYQQADVVRAFTDHEFGA..--TGPRVIHAHAVSSAYGLLGYQAGLDRL.....RATG..A..D..VDQPGYLLVQHLATCDMVLHSLF.GDHDRARIPRYHLD--KGLWRQH..E...SPHFPATTWSPAETLEETFYTREPVTSAAMSGLIARHGGSGLAVSLHECLQRYAECRDLLRDTDITLPDDPRDLREWSLVMALTGVLTALDRDLVP.nTDELVVHASGSYGVGDYTPLPPEHIVTVEDAAG.LAAT-----lge.......
A0A221W5A7_9PSEU/18-460 ..............................d-SRSLLTRYYDLLAEFAARSEPP..A.S-.-.--.SVDFEPSMRLPELDDKVVEFLSPATAGLYELGDVRGLPVRLLDLRQNPRTQTTKTFASLIIVARAVNHIRETGEPVILFSPSSGNKAVALRDAVARALTAGLVEPDQLRVVTLTPAQTTGKLRRSILSEDAELR.RLNPVFVLD.DAPPEAVKQVGREFTRLYVD--SGFDRIRLWHSLRLENYRVADIVRALYDFEFGL.aGRTDLRTVHAHAVSSAFGLLGYASGIEVL.....KERG..H..A..VADPSFLLVQHLATCDMVLHSVE.GSFDRGNVPAYAMRP-DGVWVQD..R...SDHFPHRTWSPQETLEHTFYTHEPATAAEMSGLVSAHGGTGVVVSLLECMDRYAECRALLRASAVPLPEDPRDLTEWSLVMAVTGVLNAIDRGLLR.dADGVTIHASGTYGRDDYTPLPSEWINHVDGAAQ.VLDAVLD--rah.......
A0A1Q5N6A1_9ACTN/18-458 ..............................q-CPQALTHYDEELRAVLAAAADA..P.AP.G.GAhIGGFAPAWELPAPGADLERFFAPSGISAHVLDDDGGRRIGLLNLMHNPRTRTTKTFASLVIVTRAVAHIRRTGEPVMIVTPSSANKATALRDAVLRAHESALVTPEQLRIVCVVPSGSTAKLWHGGLAVDDASR.AANPLAVLR.TEQPGDVKQLARAVVDQDAQALFADTGIRLWHSLDLRNYMVADAVRALFERDFLP..---AGARTHAHSVSSAFGLLGHFHGQQWH.....TGRQ..W..P..GVGGQYFLVQHLGTPDMVASLYH.GRFDHR--PSWVSR--DGLFHQD..Q...DPHFPQVAHDPGEQLDATFYTHTPATSPRMNEIIARQGGGGVVVSLMECLQRYPRIRHMLAPHGVHLPADPRDLREWSLVMALTGVLNGIDRGLIA..TEEILVHGSGSYGAEDFRAADPRHLRHIASLDD.LRQVVRAA-a.........
A0A8J3CD22_9PSEU/19-455 ..............................n-SDSLITRYYNGVKLASSGMGRT..P.P-.-.--.AAGFAPAHDYPELDDRWEEYFSVARAAWRPVRPYQDHDLALLDLMRNPATRTTKTTASLLMVARAVTHIHRTGERILIFTPSSGNKAIALRDAVARALQLGLVAPDQLRIATLTPLSTLHKFRRSYLTESDELR.RLNPVMVYS.GGTASDVKEIGTEFVAAARQ---RADDLRIWYSLDINNYKIADACRAFFEHEFGG..-RPRGRRLHAHAVSSAYGLLGYQHGLDTM.....ARVG..I..S..VSQPGFLLVQHMATSDMVRHYLR.EGVGTDRQVDYHLDAATSLLCQD..A...SPHFPQATWSVGENLEPTFYTNNPPTAPEMTRLISTHGGSAIVVSLYECLTRYATVRNRLGGAGCALPADPRTLGEWSLVMGLTGVLNAVDRGLVG.nFDEIVLHGSGLYFLPGEQGIELGNVTAVDNADD.VLRTV----l.........
A0A317DM36_9ACTN/9-455 .............................na--RNLIVDYYDLIPAAAARCGAA..P.GG.G.AG.TPGFAPGFDLPALTDDIREFFAAATATWRPLGEYQGHPIQLMDLTGNPGTHTTKTFASMLIVARAVEHIRRTGESICIFTPTSANKGIALRDAVGRALAAGLVKPDQLSVVVLAPASTRHKFRSDRLAGDPALR.RLSPLLRFT.RGAAEGVKALGRAFVDGYAAEAYDKHGLNLWYSLDLRNYLVADAARAAFEADASP..TSSAGPRWHAHAVSSAYGLLGYNLGRDVLe...aTGRA..E..P..ADRPGFLLVQHLGTPDMVLNLRH.GSFSRSHLPRYQRDQAGGGWTQR..E...DPHFPEVTDDPDEILDPTFYTHEPVTSPAMNDLIRRFGGDGIVVSRRECVRRYPMLRDWFAAGSRPLPEDPAQLREWSIVMALTGVLGAIDRGIVP.aGHEIVLHGSGCYTSADYVTAEPDA--EVSTVDE.VAAAVL---gg........
V6KQQ1_STRRC/14-449 .............................ds--HSLIVRYYAGVKEASLRLLGQ..S.A-.-.--.TSGFAPDFDYPQLTDTWEEFFDVARAGWDPLGSHAGRRITLLDLMKNPGTRTTKTTASLLMVARAVHHIDLTGDSVMIFTPSSGNKANALRDAVARALELELATPDKLRIVTLTPSSTLYKFRRSILTDDAELR.SRNPILVYD.GPEAGDVKQIGTDFAQASA-----GRDERVWYSLDIGNYKVADACRAFYEREFAD..PEPGKRRLHAHAVSSAYGLLGYQHGLNTM.....ADLG..I..P..YHQPGFLLVQHLATSDMVRHHLQ.AKTGELPRLNWKLNDTDGIFEQY..E...SAHFPQATWETQENLEPTFYTHNPPTAPEMTSLIARHGGSGIVVSLLECVRRYGEVRRLVNAGAQSLPVDPRQLGEWSLVMGMTGVLNGLERGLAD.gFDEVVLHGSGMYLADAKGSPDRSQVTTVRNAAD.VAAAV----y.........
A0A6B3HXI2_9ACTN/2-94 .............................rs-----------------------..-.--.-.--.--------------------------------------------------------------------------------------------------------------------------------------.---------.-----------------------ERTRFTPWFTLDLENYRIADTLRAYVEAELDP.vGPGSRPRIHAHAVSSAYGLLGYHLGVGLLesaggRGPA..A..P..HRHPGFLLVQQLATPDMV-----.-----------------------..-...------------------------------------------------------------------------------------------------..---------------------------------.---------..........
D2BFD8_STRRD/16-450 ..............................d-SESVITRYYNGVREASRRCAPA..R.S-.-.--.-TGFAPEFSYPVLTDAWEEYFAVAGASLSPLGSYAGRNLVLLDLMKNPGTRTTKTTASLLMVARAVQHIDRTGESVLLFTPSSGNKAIALRDAVARALELKLATPDKLRIVTLTPAATLYKFRRNVLTESDELR.ARNPILVYS.GPEAGDVKNIGRTFAEAE-----AGTGERVWYSLDIANYKVADACRAFYEHEFGD..AQPGHRLLHAHAVSSAYGLLGYQHGIDTM.....AALG..I..T..HSQPGFLLVQHLATSDMVRHYLT.ETKGHDPQPNWERSDADEVYEQR..S...SPHFPQVTWNPQENLEPTFYTRNPPTAPEMTALIAEHGGSAVVVSLLECVQRYGTVRHHFQASDRPLPADPRHLAEWSLVMGLTGVLNSLDRGLVC.gFDGVVLHGSGMYVAEPEQMPERSQVIEVRSAED.VAKAV----l.........
A0A810L1F1_9ACTN/5-449 .............................pt--ANLILDYYDRLPEVVAARVHD..P.SP.V.TD.PVAFSPGFRFPELDDGLREFFSVATACWWQLGEHDSHRLQLLDLTRAPGTRTTKTLASLLIVARAVEFIRQTGEPVLIFTPTSANKGTALRDAVQRAIRCGLVTPDQLRVAIVAPASCLPKLRGGLSTGDVALDpRRHPIFLYD.GESPEGVKALAREFADRYAG----KIGAHLWFSLELRNYLVADAARAFFEHDVAP..TVGAAPRWHAHAVSSAFGLLGYNLGRDVLe...eRGMA..E..A..AQRPGFLLVQHLDTPDMVLSLRR.GGFDRSLLPTYRYG--GGLYRQE..A...DPHFPAATFDPDEVLDPTFYSHAPATSPAMNELIARYGGDGVVVSLYECLQRYPQIRELLAATDRPVPADPRRLREFSLVMALTGVLNAVQRRLVP.dGTDLVVHASGSYTVDDYPPLAAADTVPVRSVAD.IAKVLL---gts.......
A0A1G9W864_9ACTN/4-447 .............................ha--ANLLLDFYDRLPTSIAACVDR..T.EP.V.RD.DTGFSPGFLLPEPDARVERFFSVATARWQPLESYSGHRLNLLDLTCNPATGTTKTFPSLLIVARAVEYIRRYGEAVTIFSPTSANKGVALRDAVLRAIDAGLAEPEQLRTVILAPRSCQAKLRSSRLSTDPALR.ALNPLLVYG.GPEPERVKAIGRAFADKYAGDLRAR-GENLWFSLELGNYLVADTARAFFEQQAAP..-AGTAPRLHAHAVSSAFGLLGYHRGRAVLe...gSGAV..S..Q..DSRPASLLVQHLGTPDMVLNLRN.GDFDRANLPAYERH--GGLYRQS..A...DPRFPQVTYDPDEVLDPTFYTHRPATSPEMNGLIERFGGDGIVVSLAECVARYPELRELLAGSGCELPADFRQLREWSLVMAMTGVLNAIDRGLAD.pWDDVVVHGSGCYTAADYLPLEPEAMIEVAGVED.VAAVV----cg........
A0A1A8ZJB8_9ACTN/9-456 ..............................t-SRNLISDYYDLIPAAVARCAPP..P.TG.A.SG.TPSFAPAFDLPALTDNVRDFFAAATAGWRRLGEYGGHPIQFLDLTGNPGTRTTKTFASLVMVARAVEHIRRTGEAIRIFTPTSANKGIALRDAVGRAIEAGLVEPDQLSVVVLAPAATRHKFRQDRLAGDPALR.AANPLLRYV.GGAPEDVKALGRAFVDKYAAEAYDRHGVNLWYSLDLRNYLVADAARAAFEADVSP..PSAERPRWHAHSVSSAYGLLGYNLGRDVLe...aAGRA..R..S..TDRPGFLLVQHLGTPDMVLNLRY.GGFSRAKMPAYRLDPVRGVTVQD..A...DPRFPAVTDDPAEVLDPTFYTHEPATSPAMNELIRRFGGDGIVVSRRECLERYPMLRDWFDGDRPMLPTDPDELREWSIVMGLTGVLNAIDRGLVP.aGHEIVLHGSGCYGGSDFVPAEADA--EVSTVDD.VAAAVWA--kp........
A0A8J3VJ49_9ACTN/11-455 .............................pt--RNLIVDYYDVIAAAAQLCGAS..A.GG.E.PG.TAQFAPGFALPSLDEEVLRFFEAATAVWRELGEHGGHRLQMLDLTQNPGTRTTKTFASMLIVARAVEFIRATGEPVCLFTPTSANKGIALRDAVARAIAAGLVTPEQLSIVVLAPSSTRAKFRHDALAADPVLR.KLNPLLSLD.SAQPEAVKALGRAFVDEYAKQARDRHGVNLWFSLALNNYLVADAARAAFEADVSP..--AAGPRWHAHSVSSAFGLLGYNLGREVL.....EGSG..A..AdvSTRPGFLLVQHLGTPDMVLNLRH.GSFSRDYLPTYRANEVTGGWEQD..V...DAHFPAVTDDPAEVLDPTFYTHAPVTSPAMNNLIGRFGGDGIVVSRRECLQRYPLLREWFAATSVALPQDPAQLREWSLVMALTGVFNAIDRGLVP.aGVEIVIHGSGSYTAQDYAPLAPDA--EVISTRD.IASAI----fgg.......
A0A841CRZ5_9PSEU/13-462 .............................gt--ANLLADFYDLLPRAIERCVPD..L.GP.AvAD.PAAFSPGYALPELDGGVREFLSVATARWQPFGEYGGHRLTLLDLTGNPGTGTTKTFASLLIVARAVEYIRRTGEPIVIFSPTSANKGVALRDAVLRAVDAGLVEPEQLRVVVLAPESCRQKLRAGRLSDDDHLR.ALNPVLLYG.GPNAEGVKPLGREFVDRHAAALR-RDGVNLWFTLQLGNYLTADVARAFFEQRVDPtdADGAAPRLHAHAVSSAFGLLGYHQGRAVLe...dLGLA..D..R..ATRPASLLVQHLGTPDMVVNLRH.GDFDQARRPDYRFDATTGLYRQS..A...DVRFPEVTYDPHEVLDPTFYTHHPATSPAMNDLIATFGGDGVVVSLAECVARYPALRALLGDGAGGLPADLRTLREWSLVMALTGVCNAIDRGLVE.eGRDVVVHGSGCYSTADYEVLGAEALTPVRTVED.IARAVS---g.........
A0A8J3MG67_9ACTN/10-447 ............................sav---AALVRWYDEIQAALRHVGAS..H.R-.-.--.ATGFHPAFELPAPTDAVVGFLGAGELSFDRLGEVAGRELTLLDLTRNPGTRTTKTMASLVMVARAVRQIQATGEPIMIVTPSSANKATALRDAVLRAYRHGLVTPDQLQIVTVVPGIAREKLWSSALSEAP-LS.GRNPMCVYH.SDVPSDVKTIADQAVGTAAPLLRDRHGINVWYSLNLDNYRPADTVRAFAERDLLP..TRPGSRRVHAHSVSSAYGLLGHHLGRVLD.....----..G..G..DAGPGYFLVQHLATPDMVLSLYH.GSADPANLPAYTYDPKSFLYRQD..T...DPHFPAATYDPAENLEPTFYTRSPVTSAEMNSIIAAQGGGGIVVSLYECLERYPQIRQMLSGTSIQLPADPRKLREWSLVMALTGVVNACERGLIE..ADEVVVHGSGSYGTDDYRAIPADRLTTVDDAAA.LHEVLLAA-g.........
A0A1C5BE87_9ACTN/7-452 .............................ae--RNLILDYYERLPQAVAALVDD..P.AP.V.TE.PGAFSPGFALPEPDADVHGFFEPARAQWRELGKYGSHRLVMLDLAGNPGTHTTKTFPSLLIVARAVEYIRRTGEPVMIFTPTSANKGTALRDAVARALAAGLATPDQLRIATLAPASGRSKLRAGSLTDDAELR.ARNPLMVYD.GERAEDVKALARQFTDAYASDLKRRHGVNLWFSLDLRNYLVADTARAFFEQDADP..TDAAGPRLHAHAVSSAFGLLGYHAGRDVLe...aAGAA..R..P..ASRPASLLVQHLGTPDMVLSLRR.GSFDRAGLPGYERG-GDGLWRQW..A...DPHFPGVADEVDEILDPTFYTHRPATSPAMNAVIARHGGDGIVVSRRECLDRYPALRELVADLPRPLPGDPRALREWSLVMALTGVCNAVDRGLVE.aGRDVVVHGSGWYADDDVRTPAESALVPVSTVED.IAAAV----l.........
A0A1R1SAM9_9ACTN/10-456 ..............................v-VENSLIRYRSQVQSALVRLGDA..D.AG.A.GP.APGFCPGHLLPDPDERLVEFFSPSGLAFHDLGSYQGKRLTLLDLMRNPRTRTTKTYPSLVIVARAVRHIMATGERVVIVTPSSANKATALRDAVWRASSSGLVAPGMLRICAVVPDSSRAKLWSSPLSEDPWLA.ARNPVFTYA.GAHPDEVKAVARGFVDGWAETFKKRHGVNLWHTLDIENYKVADVIRAHAEYEFLP..RESADERLHVHAVSSAFGLLGHNLGLRQL.....ADGG..V..N..APRSRYFLVQHLDTPDMVLSLYH.GSPDRDHAPAYTYDAADGLHRQH..E...DPRFPQATADPRERLDPTFYTRRPTTSAEMNEIIRARGGGGIVVSGHECRTLYPRIRRLLAPAGIVLPEDPGLLREWSLVMALTGVLQAIDRGLVA..EDDILVHGSGSYHAGDFRPLPEDRLTPVTEVED.LAEKAAW--av........
A0A1H2TW55_9PSEU/3-445 ..............................h-LDNALAHYYDVLKRAMNAYQRS..D.EF.V.PS.-ENFLPDFDLPVLDSTMEKFLQPSGIGITELGEHGGCSLHLLNLMSNPGTRTTKTFGSMINVARAVNHIRTTGERVFIISPSSGNKATALRNAVERAVSVGLVGDTELQIATAVPEASRHKLWSSGLSDDPRLR.ELNPMAVLP.CEVPVHVKLMIAEFMARHTDEFHERYGIRLWHTLELRNYMVADMVRALAEHDLMP..-ATGRGRLHAHAVSSALGLLGLQFGHREL.....AKAG..V..E..LPALQLLLVQHLGTPDMVLGLYH.DSFDMDLVPKYRRG-ADGLYRQD..E...DPHFPAVTFDPEEHLDATFYSRTPVTSPRINKVIRENGGGGIVVSLYECLQRYNQIRDLLAT-SVSLPADPRRLREWSLVMALTGVLNGIERGVVA..DREILVHASGSYGEDDYRVLSPADSVRIDGVED.FYQVVRHA-a.........
A0A1V4AAB1_9ACTN/21-464 ..............................e-LTNAIERYYSRIGPTLQLLLGE..D.AG.R.SP.--EFNPGPELPGMTSGIREFFSASGLHHASMGEYGGKRLALLNLALNPGTRTTKTFASLLTVARAVRFIQETGERVMILTPSSANKATAMRDAVLRALRLDLVTPEQLSVSVVIPQGSTSKLWDSELHRDPELQ.ARNPVAVYP.GTDPAGVKALARHVVDAYGSALKDAAGVNLWYTLDLNNYMAADVVRAFVESELFP..--PVAPRLHVHAVSSAYGLLGHAQGRALL....dESTR..E..H..TPRPRYFLVQHLGAPDMVLSLYH.GGTSRDLVPAYRYDDMTGLFEQR..T...DPRFPYLTADTSETLDTTFYTRNPPTSARMNELIHSHGGGGIVVSLHECLSRYAQVRALLRKARLELPADPRELREWSLVMAMTGLLNAVDRGLID..EEDVLVHGSGCYSVHDYSVLPHTALHLVENGDM.LKDVVFKA-a.........
A0A1E7KB52_9ACTN/2-454 .tdhwdtvhalvrdahprqagpapgdgdpag-----------------------..-.--.A.-D.PAGFAPDGELPALDGPLRGYLAAAGTRVTRLPDHRGVRWQLFDHCAAAGSRTAQPDTALLLVARAVQHTRRTGRRIALLAPSSGNLASTLRDALLRAHRYGLAHPDQVRVIALVPAAARHKVADSPLARHPELR.RRNPLVVHH.GAEPGSVHELAAAYCRAHARALRTGTGTALWYVRDPVEHRAAAALRAFVERDALG..AAPAAGRVHAQTADTGSAALGHRAGSALA.....ADGA..A..D..AAGPRPLLVQQPRTCGLVLHLLT.GSCSREGAPRYRYDAARRLHHQA..AgspDPHFPRTAHHPEEVVEPAFFTRAPGTAPEVSALLRAHGGTGIVVSRYECLARYPSLRALLAPAGVALPADPARLADWSLVMALTGALNAAERGLPA..GPEVVVHRTAAHGAADRAPVPVALARYADSADE.LHAVLTG--al........
A0A2U9PC88_STRAS/1-430 ..............................m-------RYYDDLSRVLADTGSR..D.R-.-.--.TAGFTPGWRLPALGPALERFFEPGGISAQDLGSYHGTPLRFLNLMHNPRTRTTKTLASLLIVARAVDHIQRTGESVLIITPSSANKATALRDAVLRAHETGLVGADQLRIVCVVPAASSHKLWRSPLTDDDVLR.ARNPLAVLD.ASQPLHVKELARALADREADALFARYGVRLWHTMDLSNYAVADTARALFERDHLP..---AAPRVHAHSVSSAFGLLGHFYGQQQH.....TGRD..W..P..GTGARYFLVQHLGTPDMVSSYYH.GRFDYR--PQWQYR--DGLHVQD..S...DPRFPGRTFAPDEQLDTTFYTRTPATSERMNEIIRRQGGGGIVVSLAECLDRYPLVRDLLQPAGVGLPADPRQIREWSLVMAVTGVLNALDRGLLD..ETEILVHGSGSYHADDYRAPQADQLRPITGYGD.LRDLVHTA-a.........
A0A120F8J4_9ACTN/1-401 ...............................-----------------------..-.--.-.--.----------------MREYLSASDLGHTPMGRYRGRNLALLDLTRNPGTMTTKTFASLVIVARAVGYIQRTGERVTIITPSSANKAVAMRDAVLRAIGAGLVTPDQLNVAVVVPAGSVHKIRASELLTDPYLR.ARNPIAVYR.GDVPGTVKTIARTMVDTHREALEKSAKTNLWYTLQLENYLAADVVRALAEEEFFP..PAATVPRLHVHAVSSAYGLLGHAYGRERF.....GGTG..-..-..-LPSRYFLVQHLGAPDMVVSLYHdGDFDSRHLPDYSYQPESGRYVQQ..E...DPHFPAVTFDPRETLDPTFYTRTPVTSARMNALIHGQGGGGVVVSLAECLERYGQTRALLGEAGVPVPANPTALREWSLVMAVTGILNAIDRDLVP..EDDILVHGSGCYATGDFDEVTLRDMHEVDTDDDsLRNVVLDA-a.........
A0A6F8XVE6_9ACTN/10-458 .............................ts--GNLLVDFYDRLPEVIAHCVPD..P.SP.V.AD.PVVFSPGFALPELDDAVRSYLAVATAQWQPVGEYRGHRITLLDLTGNPGTHTTKTYASLLIVARAVEHIRRTGRSVMIVSPTSANKGVALRDAVLRALDAGLAEPEQLRIVTLAPQTGRHKLRATRLSTDPALR.ALNPQLLYT.GKEPEAVKSLARDYVREHAATLHRTRGLDVWFSLELSNYMVADAGRALFEQRVDP.tDAADRPRVHAHAVSSAFGLLGYHAGRSLLe...sTGVA..S..A..ATRPASLLVQHLATPDMVLSLRA.AAGSAPSLPPYPLDPATGLFRQA.gA...DPHFPAVTYDPDEVLDATFYTHRPVTSGAMNEIITRFGGDGIVVSLAECVARYPYLRTWLGAALPLLPADFRTLREWSTVMAFTGVTNAIDRGLVE.pGRDVVVHGTGCYADGNLEPLCGDGLVEVADVAD.ITAAV----r.........
A0A542DFC7_AMYCI/2-431 ......................tdpapvtgd-----------------------..-.--.-.--.PARFSPGFDLPRPDAGVQRLYSAATTRWCPLGEYAGHRLTLLDLASNPGTHTTKTFASLLIVARAIAYIRRTGEPITIFSPTSANKGTALRDAVLRAIEAELVTPEQLRVVILAPESCRDKLRASRMSTDSTLR.ELNPLLLYR.GAPAESVKRLGREFVDAHAGQLK-REGRNLWFSLELANYLIADTARAFFEHAVDP.tDVSGGPRWHAHAVSSAFGMLGYHHGRTVLe...dAGLA..T..P..ASRPATLLVQHMATADMVLSLRT.GSFERHGLPRYSAEPGTGLHRQDgeG...DPHFPTTTYDPDETLDPTFYTRRPATSPAMNELIGRFGGDGIVVSLHECLHRYPEIRAMLAGHERGLPVDVRGLREWSLVMALTGVLNAVDRGLIT.pGADIVVHGSGWYSADEYQPPGESSTTTVTTVDD.IAAAV----ig........
A0A0W7X1I3_9ACTN/19-454 ............................dpl---RVLVHYYDELSRTLDATGRR..S.R-.-.--.TDAFSPGWQLPPLTPALEDFFAPGTISAQALGTHRDTRLALLNLMHNPATRTTKTLASLMIVARAAAHIRRTGEPVMIITPSSANKATALRDAVRRAHESGLADSEELRIVCVLPTSSSHKVWRSSLTDDPALS.ARNPLAVRD.SAGSHEVKELARAVADQEADAVFARHGLRLWHTLDLDNYVVADTARALFERDRLP..---AVPRVHAHAVSSAFGLLGHFYGQQQH.....TGRA..W..P..DTGAQYFLVQHLDTADMVASYYH.GAFDHR--PAWQHG--DGVYTQH..A...DPHFPQRTYAPDERLDPTFYTRTPATSPRMNEIIRKQGGGGIVVSLAECLDRYPHIRRLLEPAGVDLPADPRQLREWSLVMALTGVLNAVDRDLLD..LPEVLVHGSGSYHADHYRPPESHQLHPVAGYDG.LRDLVHAA-a.........
#=GC seq_cons ..............................s..tshlhcYY-tl.tultthssp..s.ss......ssuFsPGapLPthsstlccFhusushsap.LGpYtG+cLpLLDLhpNPuTpTTKTaASLlIVARAVpaIRRTGEsVhIhoPoSANKusALRDAVhRAlpsGLVsP-QLRlVslsPtusptKLRpStLusDPtLR.thNPlhlas.GspPtsVKsluRtas-pausthttppGhpLWaoL-LpNYhVADssRAhaEp-hhP....sutsRlHAHAVSSAFGLLGaphG+slL.....sGtu..t..s..sspPuaLLVQHLuTPDMVLsLhp.GshspsthPsYphc.tsGLapQs..s...DP+FPtsTa-PsEsLDPTFYT+pPsTSPtMNtlItppGGsGIVVSLtEClpRYstlRphLussuhtLPADPRpLREWSLVMAlTGVLNAlDRGLls..tc-lVVHGSGsYsssDapsltspthp.VssstD.ltssV....t.........
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