#=GF ID DUF6008
#=GF AC PF19471.3
#=GF DE Family of unknown function (DUF6008)
#=GF AU Williams LS;0000-0001-5551-8526
#=GF AU Finn RD;0000-0001-8626-2148
#=GF AU Fragoso S;0000-0001-7018-3891
#=GF SE Manual
#=GF GA 27.00 27.00;
#=GF TC 213.70 213.40;
#=GF NC 26.00 25.10;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF WK Domain_of_unknown_function
#=GF RN [1]
#=GF RM 15797213
#=GF RT The neocarzinostatin biosynthetic gene cluster from Streptomyces
#=GF RT carzinostaticus ATCC 15944 involving two iterative type I
#=GF RT polyketide synthases.
#=GF RA Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van
#=GF RA Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B;
#=GF RL Chem Biol. 2005;12:293-302.
#=GF DR INTERPRO; IPR046050;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This entry represents a member of a biosynthetic gene cluster
#=GF CC (BGC). This BGC (BGC0000112) is described by MIBiG as an example
#=GF CC of the following biosynthetic class, polyketide. This family
#=GF CC includes a protein from the neocarzinostatin biosynthetic gene
#=GF CC cluster from Streptomyces carzinostaticus subsp.
#=GF CC neocarzinostaticus [1] and appears to be restricted to
#=GF CC Actinobacteria.
#=GF SQ 29
#=GS A0A1Q5E1E3_9ACTN/7-255 AC A0A1Q5E1E3.1
#=GS A0A542DD10_AMYCI/1-234 AC A0A542DD10.1
#=GS A0A8J3FLB7_9ACTN/1-247 AC A0A8J3FLB7.1
#=GS K0EPT6_NOCBR/4-237 AC K0EPT6.1
#=GS A0A1C4HUA9_9ACTN/1-272 AC A0A1C4HUA9.1
#=GS A0A3N4Z0W7_9MICO/1-218 AC A0A3N4Z0W7.1
#=GS A0A2S9PTM3_9ACTN/3-259 AC A0A2S9PTM3.1
#=GS A0A370H1P3_9NOCA/1-236 AC A0A370H1P3.1
#=GS A0A2A4KMJ0_9ACTN/1-249 AC A0A2A4KMJ0.1
#=GS A0A0G3UZG4_9ACTN/7-257 AC A0A0G3UZG4.1
#=GS H5XBZ0_9PSEU/1-243 AC H5XBZ0.1
#=GS A0A221NTG9_9ACTN/1-245 AC A0A221NTG9.1
#=GS A0A7G1KSF8_9NOCA/1-237 AC A0A7G1KSF8.1
#=GS A0A2T0LNA6_9PSEU/1-235 AC A0A2T0LNA6.1
#=GS A0A1Q5NAD1_9ACTN/1-251 AC A0A1Q5NAD1.1
#=GS A0A1Q5JR88_9ACTN/1-274 AC A0A1Q5JR88.1
#=GS C7Q9W6_CATAD/1-235 AC C7Q9W6.1
#=GS A0A238Y3T6_9PSEU/1-232 AC A0A238Y3T6.1
#=GS C7Q389_CATAD/7-243 AC C7Q389.1
#=GS D6AAF8_STRV1/1-263 AC D6AAF8.1
#=GS A0A2V4BA79_9PSEU/1-240 AC A0A2V4BA79.1
#=GS A0A101SQ49_9ACTN/1-258 AC A0A101SQ49.1
#=GS A0A6B2DPW5_9PSEU/1-233 AC A0A6B2DPW5.1
#=GS A0A7X6LAX7_9NOCA/1-235 AC A0A7X6LAX7.1
#=GS A0A3N6HT35_9ACTN/2-150 AC A0A3N6HT35.1
#=GS A0A1I1B783_9PSEU/1-234 AC A0A1I1B783.1
#=GS A0A2S1Z8C4_9ACTN/1-246 AC A0A2S1Z8C4.1
#=GS A0A7W9PKV8_9NOCA/1-234 AC A0A7W9PKV8.1
#=GS G0FXR3_AMYMS/1-231 AC G0FXR3.1
A0A1Q5E1E3_9ACTN/7-255 .............mpgm---.ESTASTVDTLGAVLFIGWAVAMWGAVAVLAVGNRRPLRPGLYKVAVALIGIGVIGQIGHFQEHVAQAAYWIGHPYDPAWMTPWGNSFSRGFGQVDASKPSLGMEILHLIGNFIFLAGLVGIVQITHRVAGQlKSRKWARMGVWMQGIHGLEHVVLTLSVALGASRAIGLSTWFGAIEPGPALATYRIWWHFVANAVGTTILGIAVYHLWKEKRAVRASFgltedapaaA-------------tpaeddpartpepagr................
A0A542DD10_AMYCI/1-234 ...............mg---.-GTPSTLDTLGAVLLGLWAVVMWAAVAVLAYANRGTVRPWLFRASAGVIILGIVGQLGHVQEHFAQVGYWVAHPNERPWMTPWGTGLADGLGVVDMSKPSLGMEILHMTGNFIFLAGLVGVMLITKRALNT.RARKWGRMGVWMQGIHGIEHVVLTLSVALGANQAIGMSTFFGFLDPGPGLWTYRIWWHFVANVVGTVIFAIAVYHLWRERHTVEATY.........RTRGTS--------tapagsaep.......................
A0A8J3FLB7_9ACTN/1-247 .................MAH.HQAASVIDIAGASLLLLWAMAMWAAVAVLAYANRRTVRPWIFRGSAAVIILGIVGQLGHIQEHVAQTGYWVMHSGQQPWMTPWGDGLAAGFAGADPGKPSLGMEILHLIGNFIFLAGIAGVMIITRHALGS.RARRWARMGVWMQGIHGLEHLALTLSVALGASQAIGLSTWFGVLEPGPGLWTYRIWWHFLANVLGSVIFAVALVHLWRERRHVAATF.........DVGSHA--------paspsgwrladpsdpsdqsd............
K0EPT6_NOCBR/4-237 .................MHH.GAGATGWEIAGAIAMLSWMVVMWAAVAVLIVAMRRGVRPWMYRGSLGVIGLGVLAQIGHFQEHVLQVGYWLGHPNSPAWMTPWGTGLANGFGQVDTSKPTLGMEILHLAGNFQFLAGLVGVALITHRALAS.KARKWGRMGVLMQGIHGLEHIALTVSVALGAK-AIGLSTWFGLLDPGPGLWTYRVWWHFGANVVGTTIFVLALIHLWRERATIEATF.........RTPSERSATIAE--tp..............................
A0A1C4HUA9_9ACTN/1-272 .....mdhsgmpgmpgm---.GPTVSTVDTLGAVLFIGWTVAMWVAVAVLAIGNRRAVRPWMYKLAVALIGVGVVSQLGHFQEHVTQAGYWVAHPYAPAWMTPWAESFSRGLGQVDSSKPALGMEILHLTGNFMFLAGLVGVVQITHRVTGElKARKWARMGVWMQGIHGLEHVALTLSVALGASRAIGLSTWFGAIEPGPALVTYRVWWHFVANLVGTFILVTAVYHLWKEKRRVRESFglge.pevvA-------------atpdaseplsphgeddpapadddlsraenepp
A0A3N4Z0W7_9MICO/1-218 .................---.--------------MLGWTLVMWAAIVVLAVSHRRRVETWMLRTATGIVLLGVIGQIGHMLEHVAQAGYWIMNPYAPAWMTPWGTGLANGFGVVDPTKPSLGMEILHFVGNMLFLAGIVGVMQLTRRVTYRsTARKCATMGVWMQGIHGVEHLVLMLSVWLGAPTAIGLSTWFGLIDPGVALSTHRIWWHFLANVLGSAIFGLALYHLWREHPRIAASF.........-DTPTPAPA-----rslap...........................
A0A2S9PTM3_9ACTN/3-259 ..hgpgmhqsmpgmpgm---.GSAVSSVDTAGAVLFIAWAVAMWLAVAVLAWANRGPVRPWLYKTAVGLIGLGVVGQIGHFQEHVAQAGYWIAHPYSPAWMTPWADSLARGMGQVDMTKPSLGMEILHLTGNFIFLAGLVGIVQITGRTARHlKSRKLATMGVWMQGFHGIEHIVLTVSVAMGASRAIGLSTWFGVIDPGPALTTYRVWWHFVFNLVGTAILGLSLYHLWKEKREVKAGF.........EPEAR---------gdepvsagsdaseregvl..............
A0A370H1P3_9NOCA/1-236 .................MEH.TAEASGWAIAGAIGMVLLMVVMWAGVAVLFVGLRKPLRPWMFWTGAGVVILGVFAQIGHFQEHVLQAGYWIGHPNAPAWMTPWGTSLANGFGQVNHAKPTLGMEILHLVGNFHFLAGLAGVALLTHHALQS.KARRWGRMGVLMQGIHGLEHVALTLSVLLGSK-AIGLSTIFGLLDAGPGLWTFRVWWHFLANVLGTSIFAMALYYLWRERATITASY.........GVS-----------glprtttapagpv...................
A0A2A4KMJ0_9ACTN/1-249 ........mdhsgmpgm---.APTVSTVDTVGAVLFIGWAVAMWAAVAVLAVGNRKAVKPWLYKLAVGLVGVGVVGQVGHFQEHVTQAGYWIAHPYAPAWMTPWADSFARGMGQVDAGKPALGMEILHLVGNFIFLAGLVGIVQITHRVAGQlKARKWARMGVWMQGIHGIEHVVLTASVALGASRAIGLSTWFGAIEPGPALVTYRVWWHFVANAVGTVILCIALYHLWKEKRAVKESFgl.....lrD----V--------etaaapagseegsas.................
A0A0G3UZG4_9ACTN/7-257 .......mpgmpgmagm---.GGPVSTLDTVTAVLFILWAVSMWLAVGVLAYANRGPVKPWLYKTSVGLIGLGVIGQIGHFQEHVSQAVYWIAHPTSPAWMTPWANSLSRGMGQVDTTKPSLGMEILHLTGNFIFLAGLVGIVLITKRVAGQlQSRKWAKMGVWMQGIHGLEHVVLTASVALGAKRAIGLSTWFGTIDPGPALTTYRVWWHFVANLIGTGILALSLYHLWREKRSVKAGF.........GERTGDE-------asqtpgdgetpahge.................
H5XBZ0_9PSEU/1-243 .................MQHsHASATTLEMLGAAGLFLWAVSMWAAVAVLVYAAHRVVRPWLYHGSACVIVVGMFGQIGHVQEHFAQVGYWAANPNERAWMTPWGTGLADGFGALVSGSPTLGMEILHLVGNFIFLAGLVGVVLITREAVHS.KARKWGRMGAVMQGIHGLEHLALTVSVAAGSP-AIGISTLFGLLEPGPGLWTYRIWWHLIANVVGTVIFVVACHHLWKERRGVAASFspr...vpqP-------------rapertaesaavtva.................
A0A221NTG9_9ACTN/1-245 ................m---.GNVVSSWDTLGAVFLIAWAAAMWLAVIVLALANRGPARPWLFKTAVAVIGLGVIGQIGHFQEHVAQTGYWVAHPYSPAWMTPWGNGLARGMGQVDPSKPTLGMEILHLTGNFIFLAGLVGVMQITRRAVGGlKSRKWAKMGVWMQGMHGLEHLVLTLSVALGASRAIGLSTWFGLIEPGPALVTYRVWWHFIANLVGSVIFAVSLYHLWKERHAVKAGY.........QASGVE--------esvfvpssvstslpaseee.............
A0A7G1KSF8_9NOCA/1-237 .................MQH.TAEVSGWAVAGAIGMVVWMVVMWAGVAVLFLCLRKPLRPWMFQTGLAVVGLGVLAQLGHFQEHVAQVAYWVGHSNEPGWMTPWGTALANGFGQVDHMKPALGMEILHLVGNFHFLAGLAGVALITRHAVAS.RARRWGRMGVLMQGIHGLEHIALTVSVLFGAK-AIGLSTWFGLLDAGPGLWTYRVWWHFFANVIGTTIFAMALYHLWRERAAIAAPY.........YAATTGKAA-----ttttadea........................
A0A2T0LNA6_9PSEU/1-235 ...............ms---.-GSVTVLEVAGAAGLTVYAVAMWVAVGVLAYALRGPLPPWLPRVAAGVITAGVVGQLGHVQEHVAQAAYWVLHPEEPAWMTPWGDGLARGFHALAGGQHALGMELLHLTGNVVFLAGLVGVALVARHAAAF.RARRWARMGVWMQGLHGLEHLVLTVSVALGGP-AVGLSTWFGTIEPGPALWTYRIWWHFLANVAGSIVLTVALCLLWAERDRVAGSW.........SGARRVTPQR----apvhsna.........................
A0A1Q5NAD1_9ACTN/1-251 ........mdhsgmpgm---.APTVSTVDTVGAVLFIGWAVAMWAAVAVLAVGNRRAVKPWLYRLGVGLVGVGVVGQVGHFQEHVTQAGYWIAHPYSPAWMTPWADSFARGMGQVDAGKPALGMEILHLVGNFIFLAGLVGIVQITHRVAGQlKARKWARMGVWMQGIHGIEHIVLTASVALGASRAIGLSTWFGAIEPGPALVTYRVWWHFVANAVGTVILGIAVYHLWKEKRAVKESFgll...gdvE-------------taaapagseegsasal................
A0A1Q5JR88_9ACTN/1-274 .mdhahgghgmsgmggm---.GSTVSSMDTVGAVLFIGWAVAMWAAVVVLALGNRGQVRPWLYRTAVGLIGLGVIGQIGHFQEHVAQVGYWVAHPYSPAWMTPWANGLSRGMGQVDSSKPMLGMEILHLTGNFIFLAGLVGIAQITRRAAGElKSRKWAKMGVWMQTIHGIEHVALTLSVALGASRAIGLSTWFGLIEPGPALVTYRVWWHFVANLIGTAILAIAVYHLWKERRAVKAGYgap...vaeP-------------seagvtvavvdsadadqadagseespaaeptl
C7Q9W6_CATAD/1-235 .................MSG.GHSVPMLDTLGAVGLLVWAVVMWAAVAGLAFADRQGKSMRVYKVSMAVILIGVVGQIGHLTEHVAQAVYWIWHPEAPAWMTPWGTGMARGFGQIDKSRPTLGMEILHLVGNFIFLSGLAAVMVISRRARNT.RTRWWGKMGVWMQGIHGLEHLSLTVSVWLGAKQAVGLSTWFGQLTPGPGATTYRVWWHFWANVMGSAIFAMALYHLRREQGQIRDSF.........DESPVTPPVPV---dal.............................
A0A238Y3T6_9PSEU/1-232 .............mgip---.---TPLWSIAA-ALLVLWAAAMWTAVAVLARANRNPVRPWLYRASAGVIVLGVLGQLGHVQEHIAQVAYWTAHPNSPAWMTPWGDGLAAALGRVNPAEPSLGMEILHLTGNVVFLAGLAGIMLITRHALRS.RSRTWARMGVWMQGIHGVEHLALTLSVALGAGRAIGLSTWFGLLDPGPGLWTYRIWWHFIANIVGTVIFGIALYHLWRERREVEAAY.........RTPAGPASAV----pgrr............................
C7Q389_CATAD/7-243 ...............mnMSG.GHSVPMLDTLGAVGLLVWAVVMWAAVAGLAFADRQGKSMRVYKVSMAVILIGVVGQIGHLTEHVAQAVYWIWHPEAPAWMTPWGTGLARGFGQIDKSRPTLGMEILHLVGNFIFLSGLAAVMVISRRARNT.RTRWWGKMGVWMQGIHGLEHLSLTVSVWLGAKQAVGLSTWFGQLTPGPGATTYRVWWHFWANVMGSAIFAMALYHLRRERGQICDTF.........RDAPVTPPVPV---dvl.............................
D6AAF8_STRV1/1-263 ........mdhapgahe--M.GSSVSSLDTLGAVLFIGWTVGMWLAVVVLAYANRGPVRPWLYKTAVAVIGLGVIGQIGHFQEHAFQAGYWVAHPYSPAWMTPWANSLARGMGQVDPDNPTLGMEILHLTGNFIFLAGLVGIVQITRRAVGSlTSRKWARMGVWMQGIHGLEHVVLTVSVALGAGRAIGLSTWFGAIEPGPALVTYRVWWHFVANLIGTVILAIALYHLWKERRMVKAGY.........EVPT----------lleseagapgaapataasgeaavreptpag..
A0A2V4BA79_9PSEU/1-240 ...............me---.-HTASVWDIAGAVAMTALAVAMWAAVAVLAYATRSRVRPWCLRASVGVVAAGVLGQIGHLQEHVAQAGYWVLNPERPPWMTPWGDALARGFGIVDPATHSLGMEILHLVGNSVFLAGLAGIVLVTRYAAGS.RARRWARMGVWMQGLHGLEHLVLTVSVAIGQQ-AVGLSTWFGTLPAGPALWTYRVWWHFVANVVGSVIFAIALHHAWRERRLVTASW.........SAAT----------pgprvepdpadratssvh..............
A0A101SQ49_9ACTN/1-258 mdhahgahgmgsmsgmg---.GSGVSSWDTLGALLLTGWAVAMWAAVVVLAFGNRRQVRPWMYKTAVAVIGLGVIGQVGHFQEHVAQVGYWVAHPYSPAWMTPWGTGLARGMGQVDPTKPTLGMEILHLVGNFIFLAGLVGIAQITQRAARNlKSRKWARMGVWMQTIHGLEHVVLTLSVALGATRAIGLSTWFGLIEPGPALVTYRVWWHFVANLIGTAILAIAVYHLWKERRAVKAAY.........EAAVPAASETA---eavapatseld.....................
A0A6B2DPW5_9PSEU/1-233 ............mdmpm---.-TSTPGWDVVGATLLVLWALAMWGAVGVLAYANRGPVRPWVYRGSAAVIGIGVLGQLGHVQEHIAQAGYWLGHPNSPAWMTPWGTTLANGLQRVLPDRPTFGMELLHLTGNFIFLAGLAGVMVITRRALKT.RARRWAKMGVWMQGLHGLEHLVLTVSVASGSR-AIGLSTFFGLVDAGPGLTTYRVWWHFVANVVGSIIFGLALYHLWKERREVRATF.........SVRP----------lpdvirqa........................
A0A7X6LAX7_9NOCA/1-235 .................MNH.TAEATGLEILGAILMVAWMVVMWAAVGVLAVAVRKPLRPWMFRTALGVIALGVVAQIGHFQEHVAQVGYWIQHPNSPAWMTPWGTGLANGFGRVDHMKPALGMELLHLVGNFHFLAGLVGIALVTHHALES.KARKWGRMGVLMQGIHGLEHLALTLTVAFGTK-AIGLSTIFGLLDPGPGAATYRIWWHFLANVIGTTIFAVALYHLWRERAVIEAPF.........RTPAAAKPKRA---paaa............................
A0A3N6HT35_9ACTN/2-150 ..............pgm---.APTVSTVDTAGAVLFIGWAVATWAAVAVLAVGNGRAVKPWLYKLAVGLVGVGVVGQVGHFQEHVTQAGYWIARPYALAWMTPWADSSARGMGQVDAGKPALGMEILHLVGNCIFVAGLVGIVQITHRVAGQlKARKFA---------------------------------------------------------------------------------.........--------------grfgparv........................
A0A1I1B783_9PSEU/1-234 ...............mm---.GAPPSVLDTLGALALAGWTVAMWAAVAVLAYANRGPVRPWVYRAAAAQIFLGILGQLGHVQEHVAQVGYWVGNPNAPAWMTPWGTGLADGFGQLDRSKPSLGMEILHFTGNLLFLTGIVGVMLITHRAVRS.KARKWARMGVWTQGFHGLEHLVLMLTVWLGAPRAIGLSTWFGLLDPGPGLWTYRIWWHFVANVVGSVIFAIAVYHLWRERDRIAATH.........RPAA----------agsepgvepa......................
A0A2S1Z8C4_9ACTN/1-246 .......mehpsgmhgm---.GSAVSFVDTAGAVLFIAWAAAMWLAVAVLAYANRGPVRPWLYKTAAGVIGLGVVGQIGHFQEHLAQAAYWIANPYAPAWMTPWAHSLARGMGQVDMTKPSLGMEILHLTGNFVFLAGLVGIVQITRRVTGDlKSRKWARMGVWMQGIHGLEHVVLTLSIALGASRAIGLSTWFGLIEPGAALVTYRVWWHFVANMIGSAILAIALYHLWKEKRTVKAAY.........DEAGAQEPVSAA--harte...........................
A0A7W9PKV8_9NOCA/1-234 .................MKH.AAEAGGWEIAGAIAMVVWMVVMWAGVAVLAVGLRKPLRPWVFRTGLAVIGLGVLAQLGHFQEHVLQVGYWVGHPNSPSWMTPWGTGLANGFGQVDHTKPSLGMEILHLVGNFHFLAGLAGVALVTHHAVQS.RARHWGRMGVVMQGIHGLEHIALTVSVALGAK-AIGLSTFFGQLDPGPGLWTYRVWWHFVANVIGTTIFAIALWQLWRERATIAAPY.........RDRARTVAAKA---epa.............................
G0FXR3_AMYMS/1-231 ...............ma---.-MPMSGWDTAGAVLLVLWALAMWTAVGILAYANRGPVRRWVYRGALAVIGFGVLGQLGHVQEHVAQAGYWLGHPNAPAWMTPWGTGLASGLQQVLPGRPTFGMELLHLTGNFLFLAGLAGVMVITRRATNT.RTRRWAKMGVWMQGLHGLEHLVLTLSVAFGAPRAIGLSTFFGLVDPGPGLTTYRVWWHFAANIAGSIIFGLALYHLWRERREVRATF.........VL------------rplpavtgra......................
#=GC seq_cons ...............h.....ssssSshDshGAlhhlsWAVuMWAAVAVLAhANRpsVRPWlY+susuVIulGVlGQlGHhQEHVAQsGYWluHP.uPAWMTPWGsuLAcGhGQVDsuKPoLGMEILHLsGNFlFLAGLVGls.IT+RAsss.+uRKWARMGVWMQGIHGLEHlsLTlSVALGAspAIGLSTWFGhl-PGPuLhTYRVWWHFlANllGosIhulALYHLW+ER+tVcAua.........ps.s..........ssstss.t........................
//
