#=GF ID   DUF6023
#=GF AC   PF19487.3
#=GF DE   Family of unknown function (DUF6023)
#=GF AU   Williams LS;0000-0001-5551-8526
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Fragoso S;0000-0001-7018-3891
#=GF SE   Manual
#=GF GA   26.80 26.80;
#=GF TC   26.90 26.90;
#=GF NC   26.30 26.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   21264995
#=GF RT   Characterization of the biosynthesis gene cluster for
#=GF RT   alkyl-O-dihydrogeranyl-methoxyhydroquinones in Actinoplanes
#=GF RT   missouriensis.
#=GF RA   Awakawa T, Fujita N, Hayakawa M, Ohnishi Y, Horinouchi S;
#=GF RL   Chembiochem. 2011;12:439-448.
#=GF DR   INTERPRO; IPR046065;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents a member of a biosynthetic gene cluster
#=GF CC   (BGC). This BGC (BGC0001077) is described by MIBiG as an example
#=GF CC   of the following biosynthetic classes, polyketide and terpene.
#=GF CC   This family includes a protein from the alkyl-O-dihydrogeranyl-
#=GF CC   methoxyhydroquinones biosynthetic gene cluster from Actinoplanes
#=GF CC    missouriensis 431 and appears to be predominantly found in 
#=GF CC   Actinobacteria [1]. 
#=GF SQ   33
#=GS I0HIY8_ACTM4/1-150       AC I0HIY8.1
#=GS A0A0S9BSX9_9MICC/59-176  AC A0A0S9BSX9.1
#=GS A0A0A6U8S2_ACTUT/1-150   AC A0A0A6U8S2.1
#=GS A0A8J3Y6G7_9ACTN/1-148   AC A0A8J3Y6G7.1
#=GS A0A1I2JEL5_9ACTN/1-139   AC A0A1I2JEL5.1
#=GS A0A2T0S6F9_9ACTN/1-151   AC A0A2T0S6F9.1
#=GS A0A7M2BZA6_9MICC/57-177  AC A0A7M2BZA6.1
#=GS R4M1G9_9ACTN/1-142       AC R4M1G9.1
#=GS A0A7W7M5J6_9ACTN/1-144   AC A0A7W7M5J6.1
#=GS A0A428Y8A3_9ACTN/1-151   AC A0A428Y8A3.1
#=GS A0A7Y0JLY7_9ACTN/2-140   AC A0A7Y0JLY7.1
#=GS A0A2T0KAM6_9ACTN/1-149   AC A0A2T0KAM6.1
#=GS A0A101JIV0_9ACTN/1-150   AC A0A101JIV0.1
#=GS A0A7W7SRA1_9ACTN/69-200  AC A0A7W7SRA1.1
#=GS A0A4V2G6Z6_9ACTN/1-150   AC A0A4V2G6Z6.1
#=GS A0A6F8Y2N1_9ACTN/1-148   AC A0A6F8Y2N1.1
#=GS A0A6V8KDL9_9ACTN/3-140   AC A0A6V8KDL9.1
#=GS A0A327ZC10_9ACTN/1-149   AC A0A327ZC10.1
#=GS A0A7K2XJZ3_9ACTN/69-156  AC A0A7K2XJZ3.1
#=GS A1R9X2_PAEAT/33-167      AC A1R9X2.1
#=GS A0A8J3C0X4_9ACTN/1-150   AC A0A8J3C0X4.1
#=GS G8SAS0_ACTS5/1-147       AC G8SAS0.1
#=GS A0A6V8L5N4_9ACTN/2-142   AC A0A6V8L5N4.1
#=GS A0A7W5AIV9_9ACTN/1-150   AC A0A7W5AIV9.1
#=GS A0A285F1G0_9ACTN/1-160   AC A0A285F1G0.1
#=GS A0A8J3Y6B6_9ACTN/1-142   AC A0A8J3Y6B6.1
#=GS A0A1H2CYS7_9ACTN/1-141   AC A0A1H2CYS7.1
#=GS A0A7W7MMI9_9ACTN/1-143   AC A0A7W7MMI9.1
#=GS A0A561WQF7_ACTTI/1-150   AC A0A561WQF7.1
#=GS U5WBZ4_9ACTN/1-152       AC U5WBZ4.1
#=GS A0A2S4YE93_9ACTN/6-90    AC A0A2S4YE93.1
#=GS A0A4R6JTD9_9ACTN/1-152   AC A0A4R6JTD9.1
#=GS A0A239G415_9ACTN/1-141   AC A0A239G415.1
I0HIY8_ACTM4/1-150                  ................................MNAERGRGAVLHLSAVLILIAGAMWWWRAAP.REP.V.D..DRLLGW.....RRTA......EQ.......LLP.ESG.EQQ..MSGTVAVTD.GE.GH.EE.VAA.V.............GSG.EFLVSVVCAGDDGSRVRVS.L..G..A..........R.E.TGR.GMRCSGSRTPE..VFSVGLA.DELHLRVNVEKAGPVVFRYTLQRL--ns...................
A0A0S9BSX9_9MICC/59-176             ...............dpalnrpvsgaeldewa-------------------------------.---.-.-..------.....----......AE.......VLP.DADgEVF..HSNYGVLEA.GE.ER.EEtTAK.L.............PEG.TYALTLACRGPRRVSFNVS.H..G..D..........L.DlVDL.NLRCGTS---R..VNVVYLP.ADAVLHIAVEARRGANFAYRV-----sl...................
A0A0A6U8S2_ACTUT/1-150              ................................MSGERGRGLVLHALAALILAGGVVWWWRAAP.SQA.V.D..DRLLGW.....RRAA......EQ.......LLP.EVG.GLE..LSNTIALEP.GP.GH.EE.VVG.V.............EPG.DFLISAVCAGAEGSRVRIS.L..G..S..........G.E.SGR.GLPCSGFRTPQ..VFSVGLA.GELHMLLRAETSGPVIFRYTLQRA--ig...................
A0A8J3Y6G7_9ACTN/1-148              ............................mnrs-------SVSLYGCAAAVLLAGAAWYTVNAPpGPS.P.R..LELEGL.....RQAV......AA.......VLP.PAD.DLV..VGDTFELAE.GAtRQ.AR.AEE.M.............PFA.VYEVLLACAGEGRVRAQLG.R..S..-..........V.N.AVR.MIECGRPPVPV..QVRRGLS.GDVVLNLTAETRGTVVFGWQLFR---per..................
A0A1I2JEL5_9ACTN/1-139              ................................---------MLYGLTALILTVGVGWWWRAAP.RQA.P.A..DRLADW.....RHSA......EQ.......LLP.DTG.DQE..LADTLALDG.EG.GH.EE.VVD.V.............EEG.AFRIAVVCAGADGSRVRVG.I..G..-..........-.E.SGR.GLRCSGSRTPE..IFSVGLS.TRLRLQVAVESPGPVVFRYALQRSP-a....................
A0A2T0S6F9_9ACTN/1-151              ................................MTRDRAQGITLYALTAVLALAGAAWYVRAAP.PPA.V.D..PRIAAG.....RRTV......EL.......LLP.EVP.TQA..QAETMVLST.GD.RT.QR.SGS.V.............RSG.SYELALACLGTGQIRVRLS.T..T..P..........E.D.SGR.AVPCAPE-RPEkvALSVALA.SSFFLVVSAETEGTSVFRYRLSRVR-s....................
A0A7M2BZA6_9MICC/57-177             ..............ppdpalestvtgealkew-------------------------------.---.-.-..------.....---A......QA.......ALP.ESQ.GRS.fYSSSGYLEPgES.RT.EQ.TVQ.L.............PGG.TYAVTLACRGTRRVSFKVA.L..G..E..........S.DlVDL.TLGCANA---R..VTVVQLE.ADAVLDITVGTRSDANFAYRVSR---l....................
R4M1G9_9ACTN/1-142                  ................................--------MTLYALAVLLLAAGAVWFVRSAP.TPG.E.D..QRVAAG.....RTTV......ER.......LLP.DLA.QQT..GAETLVLKA.RA.RV.ER.NTG.V.............PTG.SYALMLICAGSGQVRLRLS.A..T..L..........V.D.SGR.AVPCGAEPQPV..VLDVSLG.SMLFLAISSEAGEEVVVRWRLVPSP-a....................
A0A7W7M5J6_9ACTN/1-144              ...............................m---------VLLVVAVLLLVAGGTWWWSARP.RSE.S.D..PRLLSW.....RLTA......EQ.......LLP.DTG.DQE..AADTMVLAG.NS.ET.AK.IND.L.............DGG.AFLVSVVCAGPDGSLVRVS.L..G..Eg........dE.D.SGR.GLRCSGARTPE..VFSVGVG.TQLRLRIAVDRIGPVIFRYTLERSS-q....................
A0A428Y8A3_9ACTN/1-151              ................................MREDRAAGVTLYAFALVLLLAGGVWFVRAAP.EVG.E.D..PEVVAG.....RAAV......ER.......LLP.DVP.RQA..QAETMVLAE.GV.RT.ER.STV.V.............AGG.SYALTMLCVGAGQVRVRLS.A..T..G..........E.D.SGR.AVPCAA-REPKpvELTVGLA.DGLFLAVSAETRGTAVFRWRATRTR-t....................
A0A7Y0JLY7_9ACTN/2-140              ...............................s--------------TALLLALGAAWWVHAAP.GDQ.A.D..KRIEQW.....RKDA......ST.......LLP.DRQ.AVI..ESDSLTLGA.ST.EQ.EV.VAS.P.............GPG.NFQVSVVCVGGPGSRARVT.L..G..El........gL.D.SGH.GMDCGSDREPD..AFSVSVV.DDLRMNVSVSDSGPVVFRYTLLRE--tp...................
A0A2T0KAM6_9ACTN/1-149              ................................MSVERGHGAVLHALAALILVIGVGWWWRAAP.HPA.V.D..RRLVDW.....RQSA......EQ.......LLP.DIG.DHE..MSNTLALEA.EA.GH.EE.VVD.V.............EQG.EFLISVVCAGSDGSRVRVS.L..G..-..........E.G.SGR.GLRCSGSRTPE..TFTVTLV.NELRLKVSVESTGPVVFRYALQRSN-g....................
A0A101JIV0_9ACTN/1-150              ................................MSGERGRGVILHGLAVLLVVAGGIWWWRAEP.AVE.S.D..PRLLTW.....RLAA......EQ.......LLP.ETE.DQE..KSDTLALAA.EG.EY.DE.VAA.L.............DGG.AFLVSVVCAGPDDSRVRVS.L..G..D..........D.D.SGR.GLRCSGSRTPE..VFSVGVG.TELHLRVVVEQVGPVIFRYTLQRNE-i....................
A0A7W7SRA1_9ACTN/69-200             .........grtmtkyflaepdsrtlrtpahs-------------------------------.---.-.-..----GG.....LESV......DS.......MLP.RLP.DRV..RRDVTILPG.GG.KL.DW.GLT.V.............DAG.RYHLQYLCVGPGELIIQVA.V..G..Q..........A.E.PPAgSVPCDGPGASM..VFSVDRA.KQVRILVLRP----------------gsqsvavgiqlapa.......
A0A4V2G6Z6_9ACTN/1-150              ................................MTGDRARGVQLYALAVALLVAGAVWWVRAAP.HAD.A.D..PRVAGW.....QDVV......TR.......LVP.DAT.PQV..QADTLVLPP.GR.TA.RR.EAA.V.............AGG.TFTLTMVCAGQGQVRVRLS.T..S..G..........N.D.TGR.AVPCADRPDPV..TLSVALA.HEFFMLMTAETDSSAVFRWRLTQA--va...................
A0A6F8Y2N1_9ACTN/1-148              ........................mdrtdgrl------SLAVLVAGAALVLAAGTAWWMAADP.TVE.A.E..PIPTAP.....PVALpepvapEQvdngsdsYLP.EFA.NTV..QRSVGRLDP.NE.SSvME.VPS.E.............KGS.EYRLQYVCLGPGDLSVRVRgT..T..D..........G.E.ILY.QLDCEG-----..-------.--------------------------nlntfqyiaadtivvvevh..
A0A6V8KDL9_9ACTN/3-140              ...........................ltdgr-----LSLAVLSACAALVLGAGGAWWVAADP.ERG.A.AptPTLAPV.....VVPE......EE.......VAP.EPP.QED..LESYLPVFP.NT.VT.RH.VGR.IesqdtfvmhvptqKDG.EYRLQYVCLGPGELSVRIK.R..T..T..........E.-.---.-----------..-------.--------------------------gemlydadcggnlstfqfraa
A0A327ZC10_9ACTN/1-149              ................................MSAERGRGAVLHLLTAMILIAGAAWWWRATP.REP.A.D..ERLLGW.....RLAA......EQ.......LLP.ESG.DQQ..MAGTLALAD.GD.GH.EE.VAE.V.............GGG.EFLVSVVCAGEDGSRVRVS.L..G..V..........D.E.TGR.GMRCSGSRTPE..VFSVGLA.SELHLRISVEEAGPVVFRYTLQR---ls...................
A0A7K2XJZ3_9ACTN/69-156             ......................esglervedg-------------------------------.---.-.-..------.....----......--.......---.---.---..---------.--.LH.HR.SSL.V.............KGE.AYEVSVVCVGTGSVRVVVG.G..G..-..........-.-.DPR.AVPCDGV--AA..RRDVGSApEELPVDVTAEAGATGMVAWQVVS---vas..................
A1R9X2_PAEAT/33-167                 pdasptstagnvvlppdpaleetvtgealeew-------------------------------.---.-.-..------.....---A......KM.......ALP.ESQ.GQSfySSNGYLNPG.ES.KS.EQ.TVQ.L.............PGG.TYAVTLACRGTRRVTFKVA.L..G..E..........A.ElVDL.TLGCANA---R..VSVVQLE.KDAILSITVGSRSDANFAYRVSR---l....................
A0A8J3C0X4_9ACTN/1-150              ................................MNVERGRGAVIYALAGGVAAAGVLWWFRAAP.TIA.P.N..PRAEAW.....RGTV......ER.......LLP.EGP.GR-..AANTVTLGP.GA.VR.EV.SMQ.V.............SDG.SYVVSVVCAGPAQSRVRVS.V..StvG..........E.D.SGR.GVRCGEDPLPM..HFTLGLA.GQFHLNLAADAGGPVMFRWALQR---ig...................
G8SAS0_ACTS5/1-147                  ................................M-SERGRGAILHGLAALVLAAGGTWWWRAAP.RDA.S.D..PRLLTW.....RLTA......EQ.......LLP.ETG.DQE..AAETVALAP.RQ.DY.EK.VSD.L.............DGG.TFQVSVICAGPDGSRARVS.F..G..G..........P.E.SGL.GLNCSGTRTPQ..VFSVGVG.TELRLRVTAEGEGPVVFRYTLQRA--.....................
A0A6V8L5N4_9ACTN/2-142              .............................slv---------VLAVGATVALAAGGAWWVAAAP.TVT.G.T..PRASTAppiepEPAV......EQplgnpadMLP.EFP.NTL..TRQIDRLDP.DE.SW.VL.MVDtA.............KDA.RYLVQYVCLGPGSLRIRIE.G..T..A..........NgQ.ELY.ELDCGGS----..-------.--------------------------fsaievtaagpsltvdvgrp.
A0A7W5AIV9_9ACTN/1-150              ................................MSSERGRGVVLHALAALILVIGLVWWWRAAP.DGA.G.D..GRLAHW.....RLTA......EQ.......LLP.DIG.EQE..VANTLVLEP.GT.GY.DE.IVE.V.............EQG.DFLVSVVCAGDDGARVRVS.L..G..G..........T.D.SGR.GLRCSGARTPD..IFSVGLT.RQLRMHVTIDASGPVVFRYALQRSS-g....................
A0A285F1G0_9ACTN/1-160              ................................MTTDRQRGVVLYSMAAVLLAGGAAWWLVTAP.DDT.KpT..SQAQQW.....RQAA......ER.......LLP.DVG.TQE..DGATLTLNP.GA.EQ.AI.STE.V.............SFG.QYSVAMVCVGGAGSTVRVS.L..D..NpetpdfsgigG.D.SGL.GMSCEQERSPE..TFPVQLS.DALRMTVSAGQDSEVVFRYSLVR---ig...................
A0A8J3Y6B6_9ACTN/1-142              ...............................m---------ALYGGAALLTAAGAAWWVAAAP.AAGdP.D..PRVAAW.....GAAA......AR.......AMSvDDV.RVA..ASGTAVLRS.GA.ER.SW.DAD.V.............SIG.QFQLRMVCAGEGVVSVRTG.P..Q..D..........N.G.AAY.TVTCGETPVPQ..AAVLGAA.GPFRMEASA-SRGTSVFRWQLAR---ii...................
A0A1H2CYS7_9ACTN/1-141              ................................---------MLYALTAVSMVIGLMWWWRAAP.RQA.V.D..DRLTRW.....RFTA......EQ.......LLP.DGG.DHE..RASTIPLDA.GT.QH.EE.AVA.V.............DRG.NFQVSVVCAGDNGSRVRVS.L..G..I..........G.D.SGR.GLRCSGSRTPE..VFSVGLA.HELHLTVTVESTTPIVFRYTLQRAN-g....................
A0A7W7MMI9_9ACTN/1-143              ...............................m---------TIYGLAGAMLFAGVLWFVRAAP.QTG.E.D..PAVTAG.....RATV......ER.......LLP.DLS.LQS..EAETMVLGA.GV.RT.ER.STS.V.............SGG.SYALAMLCVGDGQIRVRLS.T..Q..G..........V.D.SGR.AVRCGQA-EPQpvELTVGLA.DEFFMAVSAETAGPAVFRWRVVRTR-a....................
A0A561WQF7_ACTTI/1-150              ................................MSSERERGLILHGLAALLVVAGGIWWWRAAP.RAE.S.D..PRMLNW.....RLAA......EQ.......LLP.ETE.EQE..KSDTLALNA.ED.EF.ST.VED.L.............TGG.AFLVSVVCAGPDGSRVRVS.L..G..D..........D.E.SGR.GLPCSGPRTPE..VFSVAVG.TRLFLRVVADESGPLVFRYTLQRD--pn...................
U5WBZ4_9ACTN/1-152                  ................................MDGDRTRGATLYGLAAVLLLAGVVWFVRAAP.DRG.D.E..VAVAAA.....RETV......ER.......LLP.DLP.LQS..GGETMVLPA.GE.RA.ER.TTG.V.............RGG.SYKLVMLCVGDGQVRVRLS.S..R..G..........V.D.SGR.AVPCAAAGEPSpvELTVGLA.SEFYLAVSAETDGPAVFRWRVTRSR-t....................
A0A2S4YE93_9ACTN/6-90               ..................vervtdgvhsvpll-------------------------------.---.-.-..------.....----......--.......---.---.---..---------.--.--.--.---.-.............NKGvTYRLSVVCAGSGDVEIAFT.P..A..G..........V.S.SKK.DVSCDQSTFQQ..RFTA--V.DSLRIDVTARRGSTGMIRWRIDR---v....................
A0A4R6JTD9_9ACTN/1-152              ................................MTGERARGAILYSAAGVLVAAGATWWVLTAP.PGQ.S.N..DRVAQW.....RSAV......EQ.......QLP.DVD.GQA..DAQTVALPA.GA.AQ.TV.ESF.V.............DTG.SYEVSLVCRGGAESFVRVS.LsrS..G..........N.D.SGL.GVRCSGELPPD..SFEVGLG.GVMRMNITVGDEGPVVFRYTLRRV--ps...................
A0A239G415_9ACTN/1-141              ................................--------MILQGLAALLLVLGGVWWWRAAP.RDD.S.D..PRLLAW.....RLTA......EQ.......LLP.ESG.DQE..LADTVVLPA.EG.DY.EK.VAD.L.............DSG.VFQVAVVCAGPDNSRVRIS.F..G..E..........D.E.SGR.GLPCSGERTPE..VFSVGVG.TQLRLRIAADDQGPVIFRYAVQRG--a....................
#=GC seq_cons                       ........................................hhLauhAullLsuGssWWhpAAP.p.s.s.-..sRlhsh.....Rhss......Ep.......LLP.-ss.spt..tusThsLss.ss.pp.-c.sss.l.............ssG.satlolVCsGsspsRVRVS.h..u..s..........s.-.SGR.ulpCuus.pPp..shoVuLu.splhlplos-stGsslFRapLpR...s....................
//