#=GF ID   DUF6042
#=GF AC   PF19508.3
#=GF DE   Family of unknown function (DUF6042)
#=GF AU   Williams LS;0000-0001-5551-8526
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Fragoso S;0000-0001-7018-3891
#=GF SE   Manual
#=GF GA   26.80 26.80;
#=GF TC   27.10 27.80;
#=GF NC   26.30 26.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   16208464
#=GF RT   The lipopeptide antibiotic A54145 biosynthetic gene cluster from
#=GF RT   Streptomyces fradiae.
#=GF RA   Miao V, Brost R, Chapple J, She K, Gal MF, Baltz RH;
#=GF RL   J Ind Microbiol Biotechnol. 2006;33:129-140.
#=GF DR   INTERPRO; IPR046105;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents a member of a biosynthetic gene cluster
#=GF CC   (BGC). This BGC (BGC0000291) is described by MIBiG as an example
#=GF CC   of the following biosynthetic class, NRP (non-ribosomal
#=GF CC   peptide). This family includes a protein from the A54145
#=GF CC   biosynthetic gene cluster  from Streptomyces fradiae [1].
#=GF SQ   97
#=GS A0A0M9ZZE3_9NOCA/23-264   AC A0A0M9ZZE3.1
#=GS A0A0N9I0I6_9PSEU/182-338  AC A0A0N9I0I6.1
#=GS A0A0P4R5D0_9ACTN/1-106    AC A0A0P4R5D0.1
#=GS A0A1M5S5B3_9FIRM/7-222    AC A0A1M5S5B3.1
#=GS A0A7X0HH35_9ACTN/14-263   AC A0A7X0HH35.1
#=GS A0A1C1A1E0_9BACL/22-157   AC A0A1C1A1E0.1
#=GS V6MAL2_9BACL/14-239       AC V6MAL2.1
#=GS A0A4R3L6R2_9BACL/17-177   AC A0A4R3L6R2.1
#=GS A0A543B3X6_9ACTN/8-251    AC A0A543B3X6.1
#=GS A0A2S4YVU0_9ACTN/16-248   AC A0A2S4YVU0.1
#=GS A0A562VCS5_9ACTN/11-251   AC A0A562VCS5.1
#=GS A0A061M1A9_9MICO/2-255    AC A0A061M1A9.1
#=GS A0A317CY61_9ACTN/12-273   AC A0A317CY61.1
#=GS A0A1H6F4H6_9ACTN/193-378  AC A0A1H6F4H6.1
#=GS A0A364K6K3_9BACL/15-174   AC A0A364K6K3.1
#=GS M8DFU4_9BACL/15-240       AC M8DFU4.1
#=GS A0A1I3UPL5_9BACL/14-239   AC A0A1I3UPL5.1
#=GS A0A1H8DHR0_9BACL/17-171   AC A0A1H8DHR0.1
#=GS A0A4S8QB50_9ACTN/73-268   AC A0A4S8QB50.1
#=GS A0A1Z1W2Y1_9ACTN/8-257    AC A0A1Z1W2Y1.1
#=GS A0A1J4PWM9_9ACTN/19-243   AC A0A1J4PWM9.1
#=GS A0A0C2AY35_9ACTN/14-263   AC A0A0C2AY35.1
#=GS A0A841TDE2_9BACL/8-119    AC A0A841TDE2.1
#=GS A0A2U2ZBU3_9ACTN/24-160   AC A0A2U2ZBU3.1
#=GS A0A0C2QC08_9BACL/33-168   AC A0A0C2QC08.1
#=GS A0A1U9ZYC1_9ACTN/94-281   AC A0A1U9ZYC1.1
#=GS W7IXG8_9PSEU/14-251       AC W7IXG8.1
#=GS A0A7W5FGR8_9ACTN/9-274    AC A0A7W5FGR8.1
#=GS A0A5P0YP89_9ACTN/14-263   AC A0A5P0YP89.1
#=GS A0A7X2ZFR6_9BACL/33-168   AC A0A7X2ZFR6.1
#=GS A0A8J8KMS2_9ACTN/54-240   AC A0A8J8KMS2.1
#=GS A0A5C4W4F7_9ACTN/170-354  AC A0A5C4W4F7.1
#=GS A0A1H6E082_9ACTN/27-119   AC A0A1H6E082.1
#=GS A0A0N0A631_9ACTN/14-263   AC A0A0N0A631.1
#=GS F2R329_STRVP/14-259       AC F2R329.1
#=GS A0A1M6KEK4_9CLOT/7-222    AC A0A1M6KEK4.1
#=GS A0A1G9HCB7_9ACTN/68-176   AC A0A1G9HCB7.1
#=GS A0A1M4V5I5_9BACL/17-166   AC A0A1M4V5I5.1
#=GS A0A075R9Z0_BRELA/15-241   AC A0A075R9Z0.1
#=GS A0A6M5J6J8_9MICO/7-266    AC A0A6M5J6J8.1
#=GS A0A3M8D2X6_9BACL/14-239   AC A0A3M8D2X6.1
#=GS A0A6F8YS84_9ACTN/15-243   AC A0A6F8YS84.1
#=GS A0A895XK43_9ACTN/70-271   AC A0A895XK43.1
#=GS A0A5R9LS20_9ACTN/38-134   AC A0A5R9LS20.1
#=GS A0A841FC73_9ACTN/2-246    AC A0A841FC73.1
#=GS S4NVU3_9ACTN/1-119        AC S4NVU3.1
#=GS A0A1A5PB39_9ACTN/14-263   AC A0A1A5PB39.1
#=GS A0A6I4VYU6_9BACL/16-168   AC A0A6I4VYU6.1
#=GS G2GP32_9ACTN/77-193       AC G2GP32.1
#=GS A0A5Q0H3T3_SACSY/221-342  AC A0A5Q0H3T3.1
#=GS A0A0U3NTS1_9ACTN/14-263   AC A0A0U3NTS1.1
#=GS A0A6M1U9Z2_9BACL/14-239   AC A0A6M1U9Z2.1
#=GS A0A2R4FSC7_9ACTN/12-240   AC A0A2R4FSC7.1
#=GS C0Z774_BREBN/14-239       AC C0Z774.1
#=GS S4MZG9_9ACTN/29-79        AC S4MZG9.1
#=GS A0A069RD05_PEPLI/7-222    AC A0A069RD05.1
#=GS A0A1M5S7A0_9FIRM/6-221    AC A0A1M5S7A0.1
#=GS A0A0L0WE48_GOTPU/7-223    AC A0A0L0WE48.1
#=GS A0A1Q5MPK8_9ACTN/15-269   AC A0A1Q5MPK8.1
#=GS A0A5D0QQ21_9ACTN/172-356  AC A0A5D0QQ21.1
#=GS A0A6V8LBY0_9ACTN/14-274   AC A0A6V8LBY0.1
#=GS A0A6V8KXL2_9ACTN/20-248   AC A0A6V8KXL2.1
#=GS A0A7K2FHY1_9ACTN/14-263   AC A0A7K2FHY1.1
#=GS D3QAJ3_STANL/9-247        AC D3QAJ3.1
#=GS A0A4S8PBV9_9ACTN/72-267   AC A0A4S8PBV9.1
#=GS A0A3G8ZJ74_9ACTN/41-289   AC A0A3G8ZJ74.1
#=GS A0A1W2F9R9_KIBAR/168-377  AC A0A1W2F9R9.1
#=GS A0A5J6HGF9_STRAD/14-263   AC A0A5J6HGF9.1
#=GS A0A1S1V5I0_9FIRM/3-215    AC A0A1S1V5I0.1
#=GS A0A8J2VBP4_9BACL/20-184   AC A0A8J2VBP4.1
#=GS A0A1Q9LMS7_9PSEU/29-256   AC A0A1Q9LMS7.1
#=GS A0A0M8WJB8_9NOCA/35-275   AC A0A0M8WJB8.1
#=GS A0A1Q9LCB7_9PSEU/14-268   AC A0A1Q9LCB7.1
#=GS A0A0A8F2A4_9ACTN/103-360  AC A0A0A8F2A4.1
#=GS A0A7X1LUP4_9ACTN/16-250   AC A0A7X1LUP4.1
#=GS A0A1Q4VM42_9ACTN/16-272   AC A0A1Q4VM42.1
#=GS A0A7W7Q6R7_9PSEU/204-338  AC A0A7W7Q6R7.1
#=GS A0A6V8K2X3_9ACTN/14-226   AC A0A6V8K2X3.1
#=GS A0A561BPJ4_9ACTN/230-364  AC A0A561BPJ4.1
#=GS K0ATS6_GOTA9/7-199        AC K0ATS6.1
#=GS F3NBV3_9ACTN/1-87         AC F3NBV3.1
#=GS A0A4R6IWG0_9ACTN/232-360  AC A0A4R6IWG0.1
#=GS A0A1I3NE84_9BACL/16-175   AC A0A1I3NE84.1
#=GS A0A1M5SR25_9ACTN/14-263   AC A0A1M5SR25.1
#=GS A0A373D9N6_9MICO/9-262    AC A0A373D9N6.1
#=GS A0A5J6FJ68_9ACTN/14-263   AC A0A5J6FJ68.1
#=GS A0A3N2PEV3_9ACTN/12-205   AC A0A3N2PEV3.1
#=GS A0A6F8XK34_9ACTN/14-243   AC A0A6F8XK34.1
#=GS G2GML9_9ACTN/1-133        AC G2GML9.1
#=GS A0A7K2XMQ1_9ACTN/14-263   AC A0A7K2XMQ1.1
#=GS A0A1X9MEI4_9BACI/20-169   AC A0A1X9MEI4.1
#=GS A0A5Q2N311_9FIRM/22-146   AC A0A5Q2N311.1
#=GS A8MK06_ALKOO/5-220        AC A8MK06.1
#=GS W7IXG0_9PSEU/14-268       AC W7IXG0.1
#=GS A0A1A5XK34_9BACL/14-239   AC A0A1A5XK34.1
#=GS A0A2W2D186_9ACTN/93-221   AC A0A2W2D186.1
#=GS A0A853ABF1_9ACTN/4-268    AC A0A853ABF1.1
A0A0M9ZZE3_9NOCA/23-264              ..................................................................sct---RADWTASGWHRLL..PP-I.A...FSLE.....MLIATATQD..DADGDLDDLIaahsvlaeql.................pdrgatplrwhE...............AGKESVDLERR.......REQA.RETLSHALAGRGLPVPTTLRELADLLAQLGVYHHTRGtdgrhRWRALQlP---VVDLLDLPAEWLCAEN.............D.............A..R...WLMVTSMPAARL.HRALVHS..ERV-...PTIPTSIDRLA.SDVDATAAEVRLGLEGLLyqg...........vlsIERRGAAL...DS.....RQVREVPGHARIDLRMDWERI-------papdi..............................
A0A0N9I0I6_9PSEU/182-338             .......................................ddgatsdqitewavahhrpadwldeplade----------------..----.-...----.....---------..----------......................................-...............-----------.......----.-AWFTLFATQLGVTGQLTRRKLLDMLATVGVLTY-DG.....RYHTVR.PQPLAKDVLELPAELVSQLD.............S.............Q..S...DHSQYGRFAADL.VSVAGWL..SGR-...---PASLAWLA.ERALTTEQEVRRTLEFAV.................TQQMLDVS...--.....----------------------------gesdltm............................
A0A0P4R5D0_9ACTN/1-106               ....................................................................m----------------..----.-...----.....---------..----------......................................-...............-----------.......----.-------------------------------------.....------.-----------PQRETKRLD.............W.............I..R...WMMRTGPLVNGL.TTYLVDD..LGER...QEVLTSLDRLA.AATGRDADDVRIALAELVea............gdaQVHRVQEQ...A-.....-DVERLEVHQRFRLVMNWDHFHEPRMR-l..................................
A0A1M5S5B3_9FIRM/7-222               .....................................................................IKMPTEIQEYLWSRYL..PETT.F...KMY-.....VMVGYLNAE..NIKGEKATNT......................................-...............LLNANLTVERE.......IPQV.TEEKKRVLEKLGYKYPETRKEDIELLLKYNLVRIAADkdgnlLYLYNT.PVPRPEEVLNLDEEELTILE.............N.............I..R...FEIKHQHAFNMF.LTLLLNS..NGT-...--LATTLDHIH.KTTKVKYSDLKEVLEFLE.................KEGSINIK...AS.....KNVKNLRKNDKVYISINKEVFEQKRFVI...................................
A0A7X0HH35_9ACTN/14-263              ....................................................................l-ALHNDWFFSGWEHVV..PR-Q.G...FALT.....MLIGTASQH..GCTGSLDDLLqeicgghwdmiggd..........ldgaltffwpdgewD...............YEDEPEGREAC.......EARR.WEQFGAMLTAAGFPVPKTVRDLSELYLTWGLAGREETpe.gtRWTMPA.VLPLPGDLLALDPELTKRLD.............R.............N..R...WTMRTGPLVNTL.VNHLVDD..LGEP...QEILTSLDRLA.TATGQDADNVRLALAEFAqs............gdaQVYRGREL...A-.....-DAERLEAHQRFRLVMDWEHFHATRIR-l..................................
A0A1C1A1E0_9BACL/22-157              ...................................................................ci--LPKGFYEYGWAEWL..PLVN.I...STLP.....QISYCVSKE..FTREDTVQYLslhksn..........................qlfcnfEna...........diLFGTEYQINEYy.....lIYSR.ELMIKENLKKNGFSYPNTMEEVIDLFLQLGFLIQQSDqsgniILDMVIrPFPKVTD-------------.............-.............-..-...------------.-------..----...-----------.------------------.................--------...--.....----------------------------ki.................................
V6MAL2_9BACL/14-239                  .....................................................................IVIPSGFKANGWADVL..PHEM.N...VLFQ.....AFCYVVTKY..ETKAEMEQALgelka...........................legtfaT...............PTVDMFKSEQDf....egYVKL.LNKHKAFFQRSNYEYPNSREEAIQLFSKWGLLLDKGD.....VWDIPVyPFPDVTGLFKLTEAEQLALS.............Y.............V..K...LEALVHPMFSKL.VMQLHEQ..EENS..fSYSKADLKAML.NTNDEMLAEVLIKLTPYL.................------EE...PI.....DNMLDIPEDEKMSFTVVWERVYEDFLG-q..................................
A0A4R3L6R2_9BACL/17-177              ...................................................................iy--VPSGFFTYAWNLFL..PHGT.C...SVLLsvmtfIIHG-YTKT..EIVELMKAEEkelsllpf......................sfeipkffE...............CEEEKEKFFAI.......YERE.LA-VRHVLHRSHFKYPKTMIQWIHLLIQVGILGEVRReg.kiYLDMVVhPFPLPEDVLMMDELEVRQIH.............A.............Y..R...KQAEL-------.-------..----...-----------.------------------.................--------...--.....----------------------------ymvtnr.............................
A0A543B3X6_9ACTN/8-251               ...................................................................wa--LRMDWDQTGWCRFL..PWEG.A...LLWR.....-MFCEATEC..EVDGDLDELVdwy................................splDpvafg....pdffggLDARVEHRRSW.......--SD.RRRLSRLFGKAGIVYPQTARQIAEVGRMLGLYLKEEEp...qRWRAPA.ALPLPTEVLPMTPRQRQQED.............E.............Q..R...QHLLWSGPAAVI.VEVLRDV..GC-P...ERVHTSVDELA.DLICEPSETVRQSLAFLNdtrfgghlgrplmklqtTVAAGG-N...RS.....ADPERLEGREEFQLVPNWQG--------laaty..............................
A0A2S4YVU0_9ACTN/16-248              ....................................................................q-HFHSVI-GGGWLRMP..PPML.G...LLL-.....AALTGRGRP..LTRGELRPFVrnsvnpsg......................dwqascweD...............RDERPGKDLAD.......LRAA.QATSARYAAHYGLPPLSTLNDMLALMIAAGLVHEIPDadgqmRLYPTF.PLPGRHEVFPLDDEELSAQH.............A.............L..R...RHHAYGGDSSRI.IALFEPT..GLRH...QEITTSLDRLA.GVIDGHSHDARQAVLLLL.................--EGPDFT...AT.....TDISEIAPHKVFQLRCDWDTFHEHRIR-r..................................
A0A562VCS5_9ACTN/11-251              ...................................................................lm-----DWDHTGWCRFL..PWEG.A...LLWR.....MFCEATAND..VT-GDLDTLVdwy................................sevDpvafg.....peffsGLDARIEHRRS.......-WSD.RRRLARLFDKATLVYPQTARQTAWAGRDLGLYRFDPDp...pRWRVPM.ALPLPTEVLPMTPRQRQVED.............A.............R..R...QHLLWSEPAAVI.VEVLRDV..GC-P...ERVRTSVDELA.DLICEPPETVRHSLAFLNdtrfgghlgrpmmrvmtSFPQG-AD...RT.....ADPERLEGPEEFQLVPNWQA--------laaty..............................
A0A061M1A9_9MICO/2-255               ....................................................................q-TVTDILFGRGWSSTL..PPAV.V...ILFGe...lASAGPITRT..ALDSMLRAENphtpdgldssvwepl.......epwteeklaeldedfgEpde.........srtADELNAQDKAQ.......RELD.QADFARYLASKNLPVSHTFGALVDLLVSCNVLSANEA....gGLFLNP.HAPLPAEVLPLDAREAARQD.............K.............I..R...WERLHERTAQAI.IRFFRTD..EQEV...DHILVSLDQLA.KELESDPEDVRSAVKVLT.................--DEGDFS...TS.....IDIERAHPQQSFVLHVDWDVFNRNRIHV...................................
A0A317CY61_9ACTN/12-273              ................................................................vpalf--------QLGWYRWL..PLS-.A...MDFE....hLLHRFPDLS..RREAVQAQRVwdarragvdldnn...........lapdvladslpaapAwpaaar...ptgesgDEQAYEEELAD.......QQRR.IGEYDEVTTSLGIHPVRTAEQVLDLMITLGLIEVEAAde.geALRLAA.NPPLPTEVLPLSPEQRAEED.............R.............L..R...WRSRYGALSQRV.LRLFIHDasGGLS..rVTLPTSLDRLA.TAIGSDAEDVRHAVQVLI.................--DEGDFS...AQrqgapVDAERLVPHQRFDLVVDPSRFYADRIS-v..................................
A0A1H6F4H6_9ACTN/193-378             ................................................................qsgrt----------GWEAVL..GLPC.Q...EVLH.....AVQVAAAAG..DATEEQIAAA......................................-...............YQPWSSSSGDW.......SGPL.AEDLSDYAVQLGVPAPATRQELLRLLVAAGLVIAETSae.vtRYRPSA.SPPPVEEVLRLPDEQVTMIR.............R.............Q..D...AFHRYTSFAADL.AAVAMWS..PGC-...-TVSATLEELS.HQLLATEEEIHGAIRY--.................--------...--.....----------------------------gteralfstsgdeg.....................
A0A364K6K3_9BACL/15-174              ....................................................................i-TLPASFLQNGWNLFL..PKGT.I..sIMLS.....VMTYILQGY..SK-AEILELMimee.............................eelslTpfnft.....vpftyKTEEEKQVYLT.......ISRQ.EKRIYKVLERSGYTYPKTIQEWVELLIELKIIQEVIRee.kiFLDIVIePFPHPKEVLTLTTDELKKLD.............K.............Y..Q...INQHIE------.-------..----...-----------.------------------.................--------...--.....----------------------------slse...............................
M8DFU4_9BACL/15-240                  ....................................................................v-AIPGAYAGHGWSNVL..PHEM.N...VLFQ.....ALCYAVTKG..ESKAEMREIVdgfeg...........................leglfaE...............PTEDMFNSKEDf....enYKSL.LERHKKVIVRSGYEYPKSREEAIALFERWGLLIDKGD.....VWDIPInPFPDALDTFELTEAEQYALR.............Y.............V..R...FEALVHPFFARL.VMTLHER..DDES..fTFTKAELKEML.NTNDSMLAEVLIKLTPYM.................------EE...AI.....ENMLEIPEDEPMTFSIVWERVYEDFLG-q..................................
A0A1I3UPL5_9BACL/14-239              .....................................................................VVIPSSYTANGWSSVL..SHEM.N...VLFQ.....AFCYVTTKY..ETKAEMEAALkgfka...........................legtftA...............PVKKQFKSEEDy....ngYVNL.LNRFKAFLSRSNYEYPTSLEEAVALFEKWGLIIDKGD.....VWDVPVyPFPDAADLFQLNEAETLALA.............H.............V..K...LEALVHPIFSRL.IMMLHER..DENS..fTLSKAELKSML.NTNDEMLAEVLIKLTPYM.................------EK...AV.....EGILEIPEDESMTFTVVWERVYEDFLG-e..................................
A0A1H8DHR0_9BACL/17-171              ....................................................................v-CVPDGFFRNGWNLLL..PKGTcS...VILS.....VMSYVIQGL..DKAEILDSMKe...................................eeErlcltpfhfqiphefPTDEEKEWYMS.......LWQR.EKDVKQILERSGLSYPQTVTQWIHLLVRLGIFLEVRRks.adYFDLVIePFPYPEEYLHLSGPELNWLY.............Q.............Q..R...------------.-------..----...-----------.------------------.................--------...--.....----------------------------ksfpp..............................
A0A4S8QB50_9ACTN/73-268              .......................................................witearehhfgtsa----------------..----.-...----.....---------..----EVIEKE......................................-...............AREEYDRATAE.......RSER.IATFTTHCERAGLPVPHTVRDLLEFLLALGLYRGETRd...gQLFVAPqLYINPFDVLAFGKLEAIEEAadqrgdleeltaiA.............I..R...RVGGVEYDFDDE.GHFVLPG..GGKS...VEVELSLNELG.DDAGVPAQVVRGMLMELS.................--EDGDVA...SS.....SNLATIALDEEFTLTA------------sdd................................
A0A1Z1W2Y1_9ACTN/8-257               .....................................................................MAMHNDWWATGWEHVL..PR-Q.G...FPLT.....MLISTASQP..GFTGSLDDVLqevldghwdmiggd..........ldgaltfswpdtewD...............YEEAPEGREAF.......EANH.WKNFGAMLRSAGFPVPTTVRDLSELYLTWGIASREETpd.glRWSMPA.VLPLPGDLLPLDAELTARLD.............R.............M..R...WSTRTGPLVDQL.ISHLADD..LGEP...EEILTSLDRLA.AATGKDADDVRLALTELVes............gdaRVRRGEEP...A-.....-DTERLEAHRRFRLLMDWDHLYETRMK-l..................................
A0A1J4PWM9_9ACTN/19-243              ....................................................................d----------------..----.-...----.....--FGTACQP..GFTGSLDNLVhelfdghwdmig.............gdldgaltfswpdEewd.........yeaAPEGREACEAA.......---R.WEQFSTMLTTAGFPVPTTVRDLSELYLTWGLARREETpd.gtRWSMPA.ALPLPGDLLPLDPELTERLD.............S.............I..R...WTMRTGPLLDTL.SDHLVDD..LGEP...AETLTSLDRLA.AATGQDVDDVRLALAELVks............gdaRVQRGEEP...A-.....-DAERPEAHRRFRLVMDWEHFHENRIQV...................................
A0A0C2AY35_9ACTN/14-263              .....................................................................MAMHNDWWASGWDHVL..PR-Q.G...FPLT.....MLIGTASQS..GFAGSLDDLLqeifggswdmiggnl.......dgalsfswpdeewdyiE...............APEGREACEAS.......---R.WEEFGALLTAAGFPVPTTVRDLSELYLTWGLARRKETpd.gtRWSMPV.ALPLPGDLLPLGADLTARLD.............R.............I..R...WMWRTGPLVDSF.INYLVDD..LGEP...QEVLTSLDRLA.AATGQTADDARIAIAELVqa............gdaLVYRGQEL...A-.....-DAERLEAHRRFRLVMNWNHFHATRIT-l..................................
A0A841TDE2_9BACL/8-119               .................................................pffsvsiasgfnweetvaym----------------..----.-...----.....---------..------EKKSkpn................................tfiDlnd.........nsvNQRDNEDEEAH......sLYER.EAEIKRKLQANGFQYPKSIFDVIDLYVALGLALKTEDqqgkwCLDMIIrPLRNIDEVL-----------.............-.............-..-...------------.-------..----...-----------.------------------.................--------...--.....----------------------------t..................................
A0A2U2ZBU3_9ACTN/24-160              ..................................................................rma----RQHMAGGWTRAL..SAAG.V...LIL-.....GAVASRGRA..VTRAELGGVLpv.................................epvD...............GDRWAAPC--Wfd..ldeDAAR.VATLDRYAAAYKLGPVRTCADLLDLFAAAGVLWVDGD.....KIGPVA.PVPGVDEVFTVDDAERAEIA.............R.............L..R...V-----------.-------..----...-----------.------------------.................--------...--.....----------------------------tsvr...............................
A0A0C2QC08_9BACL/33-168              ....................................................................c-VIPNQFYESGWGLWL..PM-P.N...VTLVpyfsnAIAIGLSRD..DTIIYLENKIkpntfl.........................dfeeagiT...............PTEFDMDEKQM.......LYER.EKEIKRRLEANGYQYPKSINEAVSLYVTLGLAVEEVGeqgriCLDMLIrPLRKIDDVL-----------.............-.............-..-...------------.-------..----...-----------.------------------.................--------...--.....----------------------------i..................................
A0A1U9ZYC1_9ACTN/94-281              .................................................................sgrt----------GWQAVL..GLPC.Q...EVLH.....AVQVAAAAG..NATEEQIAAA......................................-...............YQPWSSSSGDW.......SGPL.AEDLSDYAVQLGVPAPATRQELLRLLVAAGLVITETSae.vtRYRPSA.SPPPVEEVLRLPDEQVTMIR.............R.............Q..D...AFHRYTSFAADL.AAVAVWS..PGC-...-TVSATLEELS.RQLLATEEEIHGAIRYGT.................--ERG---...--.....----------------------------lfstsgdegvvm.......................
W7IXG8_9PSEU/14-251                  ...................................................................av--SRQVFEGLGWERFT..PHAA.A...GVLGv...iVLLGAPTRE..QI-ARLAGQSsdaavge.......................aapawvglEpwd.........acgPDRERAKV---.......LRDL.VAEVDGYARGLGVVEPRTVGDVLDYLVACRVVTGFVEdr.raRFRLNP.RAPLPAEVLDLPAEVVAAED.............E.............L..R...WLALHRPVVRGL.IDLFGAH..GDDP..vDVLHTSLGELA.GALRVEVESVRAAVVILG.................--EQPDFE...VG.....PDPERLRAGEPVRIAVDWANFLDFRFDV...................................
A0A7W5FGR8_9ACTN/9-274               ................................................................vrvsa------LFQLGWFRWL..PTAA.I...DVDG.....LLHACPGEP..RDEAGQALALlharrgglkldegddavklealqrlsatlppapawhdpTqdi.........dlaTLDDPADVEAEr....aeHAEL.VAQHDAMLAKAGLAPARTVDDVIGLMIRFGLITVEGEq...qRLTLAT.DPPLPTEVLPLSEEEKQRED.............S.............L..R...WRSRFGRLSQRV.LRLFLTE..QGDLa.kTRMTTTVDRIA.VTLEADPDAVRQAILVLI.................DEGDFTVErqsAS.....IDIERLAGHQRFDLVVDPVKF-------gerg...............................
A0A5P0YP89_9ACTN/14-263              .....................................................................MAMHNDWWLSGWEHVL..PR-Q.G...FPLT.....MLIGTASQP..GFTGSLDDLLheifdgrwdmigg............dldgaltfswpneEwd..........yeaAPEGREACEAA.......---R.WEEFSTMLTTAGFPVPQTVRDLSELYLTWGLATREETse.gtRWSMPA.ALPLPGDLLPLDPELTERLD.............G.............I..R...WTRRTGPLLDTL.IAHLIDD..LGEP...AETLTSLDQLA.AATGQDVDDVRLALAELVts............gdaRVQRGEEL...A-.....-DAERLEAHRRFRLVMDWAHFHENRIQV...................................
A0A7X2ZFR6_9BACL/33-168              ....................................................................c-VIPNQFYVSGWGLWL..PMPN.V...TLLPyfsnsIAIGLSRDE..---------Tiiylenks.....................kpntfitfeDng...........ikSSEFDMDEEQM.......LHER.EKEIKRRLEANGYLYPKSIIDVVSLYVTLGLAFEEKDqqgrvCLDMIIrPLRKIDDVL-----------.............-.............-..-...------------.-------..----...-----------.------------------.................--------...--.....----------------------------i..................................
A0A8J8KMS2_9ACTN/54-240              ...............................................eewfeqspghseeevrshydqv----------------..----.-...----.....---------..----------......................................-...............--------VEA.......RTRR.IETFTECCSRAGIPVPLTLRHLVDCLIALGVLDEVTGpd.geTWVIAQ.FAANPLDILPLTPTEAAEEA.............A.............A..QmleRGVLAGIGLRRL.AEEQAPD..GGG-...TTVRVTLRRLG.DEIGLTPAATRLALDLIA................aEESWISVE...PG.....VSLLTVGPDEVFLIRAD-----------hsllaq.............................
A0A5C4W4F7_9ACTN/170-354             ..................................................................ast----------GWRRCLglPG-Q.E...VLYA.....VQLASATGE..ATEDRVAAAY......................................-...............-QPWSSGSGGW.......GSPL.SEDLSDFAAQLGVPAPTTRLDLLPLLVAAGLLIAETAgg.ltRFRLAP.EPPRAEEVLDLPADQAAMIR.............R.............Q..D...DHKRHTCFAADL.AALAVWS..PGG-...-VVTATPEELA.GRFLATAEEIRETIRYGV.................--------...--.....----------------------------ergllsvpadatf......................
A0A1H6E082_9ACTN/27-119              .........................................................sgsgpwdaalsv----------------..----.-...----.....---------..----------......................................-...............-----------.......----.--ELPEYAVKLGVPAPATRRELLRLLVAAGLVTTDGE....tRYRVVE.TPPRAEDVLRLPAGQSATIR.............-.............-..-...------------.-------..----...-----------.------------------.................--------...--.....----------------------------gqdahrryapfaadlwtmg................
A0A0N0A631_9ACTN/14-263              ....................................................................l-AMHNDWWASGWDHVL..PR-Q.G...FPLT.....MLIGTASQP..GFTGSLDELLqelfeghwdmiggd..........ldgvltfswadeewD...............YEEAPEGREAN.......EAHR.WEKFGAMLTAAGYPVPKTVRDLSELYLTWGLARREETpd.gtWWSMPA.ALPLPGDLLPLDADLAKRLD.............R.............I..R...WTLRTGPLVDGL.INHLVDD..LGEP...QEILTSLDRLA.AATSQDADDVRIALAELVqs............gdaRVQRGQEP...A-.....-DAERLEAHQRFRLVMNWDHFHEHRLQ-l..................................
F2R329_STRVP/14-259                  .....................................................................MAMHNDWWESGWEHVL..PR-Q.G...FPLT.....MLISTACQP..GFTGSLDDLLqesfdghwnmig.............gdldgaltfswpdEewd.........yeaAPEGREACEAA.......---H.WEQFSALLTTAGFPVPKSVRDLSELYLTWGLASREETpd.gtRWSMPA.ALPLPGELLSLDPELTARLD.............G.............M..R...----TGPLLDAL.IDHLVGD..LGEP...AETLTSLDRLA.AATGQDVDDVRLALAELVss............gdaRVQRGEEP...A-.....-DAARLAAHRRFRLVMDWQHYHENRIQV...................................
A0A1M6KEK4_9CLOT/7-222               .....................................................................IHMPKEIHEYLWLRYL..PETT.Y...KMY-.....IMIGYLQTE..KIRGDEATKK......................................-...............LLGANLKEENA.......IPKV.IEEKKRLLKSLGFKYPENRQDDLKLLLDFNLIKIGKDkednvVYVYNI.PVPKPQDILKLNEEELQTLE.............N.............I..K...FEIKYQNAFNMI.LTLLINN..NGN-...--LMSTLEHIQ.TTTKVKLTDIKLVLEYLV.................KEGSISVR...TQ.....KDISKLKKADKIFIKINEDVFEEKRLV-l..................................
A0A1G9HCB7_9ACTN/68-176              .................................................dvddwiaeasehhlgasaev----------------..----.-...----.....---------..------VEKE......................................-...............AREEYDRATAE.......RSER.IDTFTTHCRRAGLPVPHTVRDLLEFLLELGLYRSEKRe..gvMYVAPQ.LYINPFDVLSFDKLEA----.............-.............-..-...------------.-------..----...-----------.------------------.................--------...--.....----------------------------ieeaadqr...........................
A0A1M4V5I5_9BACL/17-166              ...................................................................iy--VPSGFLRNAWNLCL..PKGT.L...SILL.....SVMSYVLQG..LSKEELLEQMrreeke..........................lhlspfT...............FHLKNDGADGE.......IIKR.ENEVRKLLERSGYEYPQNIESWLSLLVQVGILIEIRYkn.riFLDLVVePYPVPEKILTFQDDELHFLL.............I.............H..R...ESLKTH------.-------..----...-----------.------------------.................--------...--.....----------------------------k..................................
A0A075R9Z0_BRELA/15-241              ....................................................................i-IIPKGYDMHGWSTVF..SHEM.N...VLFK.....AVCYAVSKL..ETKEEMLKSIystra...........................legtfdT...............LDKNKFHDEENy....enYVAL.LEKYANFLKRSNYEYPATAQEALDMFIKWGLVIDKGT.....SLDVPVdPFPEVVDTFELRDDEMFALY.............H.............I..R...LESLIHPVFSQL.VMYLHEK..EENE..fSLSKNEIKEILgGINDNMLTEVLIKLTPYL.................------EE...PI.....ERFQEIPDNEKMEFKVVWERIYEDFLG-t..................................
A0A6M5J6J8_9MICO/7-266               ...................................................................vl--FQSVYLDSGWARIL..PNAA.I...EPAQi...aVRLQGATLE..QFHAELAGSPhsaeglasdaweplh.......qytddelaeldehfegTpfassd...eerqrtAAQVMAHEAQL.......RVAE.VAEMDRFAAHLSVAPVRTFRDLIEFMTAAGVLRLNGG.....TYELNP.SALLPEEVLPLSDDVRHREE.............S.............L..R...WQRLHEETEYAI.IELFRPH..ELAP..aDRIATTLSQLA.NELARPVESVREACAQLV.................--AAPDFS...TT.....HDMLVIGVDEPFTMSVDWEIFFATRIS-v..................................
A0A3M8D2X6_9BACL/14-239              ....................................................................t-VIPGGYRANGWSSVL..PHEM.N...VLFH.....ALCYLVAKY..DSKEEMIQGFreina...........................lngtfdT...............LDKAKFKSEESy....enYINL.LETHKEFLKRSNYEYPQTKEEAIELMIKWGLVLDQGD.....VWDVPVhPFPEAQDIFVLNEREKFALD.............H.............L..K...LESLIHPIFSKL.ILHLHEQ..DDNH..fSMTKAEMKKLL.DIEDTLLMEVLVKLIPYL.................------KA...PI.....ENLQDLSDTDPMEFTVEWEKVYEDFLG-g..................................
A0A6F8YS84_9ACTN/15-243              ............irwlpcsfayltvvpdqhrfsrkawsmlpwdkavwcdpgsvddwvaraqrhhprrea----------------..----.-...----.....---------..----------......................................-...............-DHAELHAREHydrvvrvRAAR.VELFTEMCRRRGLPVPHTLEELLSCLVGFGLFEM-DG.....EWLTPR.LDQNPIDLLPLAGDEILNEE.............R.............A..Q...RDDRTVLVAITL.RELAGRT..RRRWr.rRQVTTDLHAFA.SALRMPEAEVRRALAHLG.................EIAGIQVD...P-.....---PPAVARDRVRVTVAWPSFARR----fp.................................
A0A895XK43_9ACTN/70-271              ...................................................dvddwiaeaqenmpgtsr----------------..----.-...----.....---------..----EVAEKE......................................-...............ARDEYDHTTQE.......RSER.IERFTTACRRAEVPVPHTVRQLLQFLINIELYREFTGpd.geQWLAPQ.LTRNPLDVLAFDQSEALEES.............AdqrsdyeelttiaI..R...NLIGDAPHSHGL.SADVTLD..DEQP..dVSGAVNLHALA.EVADVPAPVIRGMLLELA.................AKGDISTE...-D.....TDLETVKIDESFEL--------------sasv...............................
A0A5R9LS20_9ACTN/38-134              ................................................................srsve----------------..----.-...----.....---------..----------......................................-...............-----------.......----.-------------------------------------.....------.-------------------R.............Q.............L..R...IDSVYEGDSYRS.IELFDPD..GQRR...SEVKTSLDRVA.RLIEGDTHGRREALRLLT.................--ETGDFT...TS.....RDLTGLPPYRVFAIRRDGEQFDQQRIA-i..................................
A0A841FC73_9ACTN/2-246               .........................................................tqgqwlwlllrg----------------..----.-...----.....-----ATGS..EADGDLDALVargqrsgerwfdna..........tgglegpifwgfstD...............EQWRTSEIDAS.......DRQR.RERCVGALGRLGLREPRTVRDLALLMGRLGLCRHEVVgg.teRWRIPQ.MLPLPSEVLPMDPEWERESD.............E.............G..R...WQYQIAAIAGEL.AELFTED..LNKP...DEVTTTITELA.RLIERDTEDVRHGLVDFAvnplvfl..ssativslTVDTPEGL...VH.....ADPERLDDDESFRISFDWAALAERRLR-v..................................
S4NVU3_9ACTN/1-119                   .....................................................................----------------..----.-...----.....---------..----------......................................-...............-----------.......----.-------------------------------------.....---MPA.ALPLPGDLLPLDADLAKRLD.............R.............V..R...WALRTGPLVDGL.INHLVDD..LGEP...QEILTSLDRLA.AATSQDADDVRSALAELVas............geaRVQRGPEP...A-.....-DAERLEAHQRFRLVMDWDHFHENRVQ-l..................................
A0A1A5PB39_9ACTN/14-263              .....................................................................MAMHNDWWVSGWEHVL..PR-Q.G...FPLT.....MLIGTASQP..GFTGSLDDLLreifdghwdmiggd..........ldgaltfswpdeewD...............YEEAPEGREAN.......EANR.WEKFGAMLTAAGYPVPRTVRDLSELYLSWGLACREETpd.giRWSMPA.ALPLPGDLLPLDPELTERLD.............G.............I..R...WTMRTGPLLDTL.IDHLVDD..LGEP...TETLTSLDRLA.AATGQDVDDVRLALAELVks............gdaRVQRGEEP...A-.....-DAERLEAHRRFRLVMDWEHFHENRIQV...................................
A0A6I4VYU6_9BACL/16-168              ....................................................................l-QVPAVFFELGWNLYL..PQGM.N...SVVLsvvtfIYQGYSKSE..-IFFYMEEEAkklamepf......................pldkihkqE...............LM--SYHVHHE.......LYLR.EQWCESILVRSSLRYPTTISDMVQLLIDIGILIEVNYre.itYLDLILqPFPRPKESLVLTPEENDRA-.............-.............-..-...------------.-------..----...-----------.------------------.................--------...--.....----------------------------kqqiqlfr...........................
G2GP32_9ACTN/77-193                  ....................................................................l-AMHNDWWASGWDHVL..PR-Q.G...FPLT.....MLIGTASQP..GFTGSLDELLqelfeghwdmiggd..........ldgtltfswpdeewD...............CEEAPEGREAN.......EAHR.WEKFGAMLMAAGYPVPKTVRDLSELYLTWG-------.....------.--------------------.............-.............-..-...------------.-------..----...-----------.------------------.................--------...--.....----------------------------...................................
A0A5Q0H3T3_SACSY/221-342             .................................................................ldpa----------------..----.-...----.....---------..----------......................................-...............-----------.......----.-----DVAAQLGVPAPTSPRDLLAVFAAAGLLVADGD.....AYRWPE.VEPRAQDVLDLSPERRAELV.............L.............W..Q...ESDRFRSLAADL.VSVALWG..GAR-...----QTVAALA.ARTLVAEDDVRDTLDWAV.................--------...--.....----------------------------rqglltvegp.........................
A0A0U3NTS1_9ACTN/14-263              .....................................................................MAMHNDWWTSGWEHVL..PR-Q.A...FPLT.....MLIGTASQP..DFTGSLDDLLqeifdgrwdmiggd..........ldgaltfswpdeewD...............YEEGPEGRDAN.......EAKR.WETFGAMLTAAGFPVPQTVRDLSELYLTWGLASREETpd.gtRWSMPA.ALPLPGDLLPLDAELTKRLD.............G.............I..R...WMMRTGPLVDTL.INYLVDD..LAEP...QEVLTSLDRLA.AATGRDADDVRLALTALVqa............gdaQVYRGQEQ...A-.....-DAERLEAHRRFRLVMNWDHLYENRMH-l..................................
A0A6M1U9Z2_9BACL/14-239              ....................................................................t-VIPTGFTANGWSSIL..SHEM.K...VLFQ.....SMCYVVSQY..DSKEEMTKALdgi................................kglKgt..........fakPKKSMFKSEADl....eaYKKL.LEKHKAFLERSNYTYPASREEAIQLFEKWGLVLDKGE.....VWDVPIePFPDVQDLFVLSDAEKFALN.............H.............I..K...LETLVHPVFSRL.VLALHEK..DDNT..fRMSKAEMKELL.KTNDAMLAEVLIKLTPYL.................------QE...PI.....ENMLDIPDDQKMEFTVVWERIYEDFLG-d..................................
A0A2R4FSC7_9ACTN/12-240              ..........pswirwlpcafvyltvvpgeprfrrsawsaivpwegsawcdpgsvdewvdrarrrragr----------------..----.-...----.....---------..----------......................................D...............ADDAELHARQHyawmvriRATR.IELFAEMCRRRDLPVPHTVGELLLCLAEFGLFEVTEGdg.ddPWVTPR.LDRDPLEVLPLSESERELEA.............R.............A..Q...RDDQAVLVAIAI.RRLAQRT..RRRWr.rRVVSTSLTSLA.GAAGVTEEQARRSLADLG.................QI------...--.....----------------------------aelgidagrggdwlrlsvpwp..............
C0Z774_BREBN/14-239                  .....................................................................VVIPSSFAANGWTSVL..SHEM.N...VLFQ.....AMCYVVTKH..ESKEEMRKALde..................................fdAlkg........tftkPVQEGFKSEEDf....kgYVNL.LNRFKSFMSRSEYAYPTSLDEAIELFVKWGLVIDNGD.....AWDVPVyPFPDASELFKLSEAESLALA.............H.............I..K...LEALVHPMFSRL.VMKLHEQ..EENT..fSMSKAEMKQLL.NTNDQMLAEVLIKLTPYM.................------EE...AI.....ENMLEIPEDEKMNFTIVWERIYEDFLG-q..................................
S4MZG9_9ACTN/29-79                   ....................................................................l-VMHNDWWASGWDHVL..PR-Q.G...FPLP.....MLIGTASQP..DFTGSLDDLF......................................-...............-----------.......----.-------------------------------------.....------.--------------------.............-.............-..-...------------.-------..----...-----------.------------------.................--------...--.....----------------------------rrsskatg...........................
A0A069RD05_PEPLI/7-222               .....................................................................IKMPKEIHEYLWTRYL..PETT.F...KLY-.....VMVGYLQTE..KIAGEQATAL......................................-...............LLRANLPVENN.......NPAI.IEEKKRILSSLGFEYPNNRKEDLELLLRFKLVTIVKNsegklEYMYTL.PVPKPEDVLEIGEEEKQALE.............N.............I..K...FEIAHQNAFNML.LTLVLNN..NGS-...--LMSTVGHIE.NTTRVKISEIRSVLAFLE.................EEGSIKIN...AH.....KDVNSLKKADKVHVTINKEIFEQKRCV-l..................................
A0A1M5S7A0_9FIRM/6-221               .....................................................................INITKLMEEYMWFRYL..PETT.Y...KTY-.....IMIGHLQNE..DLRGEEASKK......................................-...............LLTSHFEIKHE.......TGQL.KEEKERVLQKIGHKYPTNRLEDLELLLSYRLIKVVKDedgnlVYLYNI.PIPKPEEVLNLDQEEKSILE.............N.............I..R...FEFKHQDAFNSI.LTLILNS..NGN-...--LMTTLDNIH.DVTKVKHSDIKEVLDYLV.................KEGSIKVK...AD.....KDVKQLRKSDKIYINIDKDVFEKKRFI-i..................................
A0A0L0WE48_GOTPU/7-223               ....................................................................v-TIPIEINDYLWTRYM..PETT.Y...KVY-.....ILIGYLNEQ..NIVGEEATKT......................................-...............ILDADIEEKNT.......IDKV.LEQKKEVLGKLGLKYPENRQDDLDLLVNFKLINIDKDdegntVYKYNI.PVERPEEVLELDEEELKVLE.............D.............I..K...FELKHESALNMI.LTLIINN..NNN-...--LLCSVDHIS.KTTRVKIAEIREVMDYLV................nKEGSIKIK...SD.....KPISKLKKNDKIYISVNEEVFEKKRLV-l..................................
A0A1Q5MPK8_9ACTN/15-269              ....................................................................l-ALHNGWFPSGWPNYL..PQHQ.A...MMLC.....MVFGTAAVR..GLRGSLDEVTqqlfngepgaffgrpgg....tldspvvwrdddeleylE...............TDEDKDQFRTD.......AAEH.QARCEGLLRAAGVAVPTTVRELADTMLALGIATVQDG.....VWSMQD.PIPGPETILDLTDAELARIA.............D.............M..R...RVWESGPAESTL.LNYLTDV..LGQP...DEVFTSVDRLA.QASKLREDDVRYVLGRMIqe............neaRVERGTPR...KQ.....VNLDDLKNHERFHLVADWQHFNENRIMI...................................
A0A5D0QQ21_9ACTN/172-356             .....................tgwrtclglpgqevlsavrlaaatgeatedriaaayqpwssgsgdwns----------------..----.-...----.....---------..----------......................................-...............-----------.......---P.IDDLSRFAAQLGVLAPATRRDLLPLLVAAGVLITETAgg.vtRYRLAP.DPPRAEEVLELPADEVAMIR.............Q.............Q..D...ARQRHTSFAADL.AALAVWS..PVG-...-AVTATPEELA.DRLLATAEDIRDTIRY--.................--------...--.....----------------------------gvecallripanatfnaq.................
A0A6V8LBY0_9ACTN/14-274              ..................................................................vpv------LFQLGWFRWL..PHAG.FdfeELLH.....RFPGTPREE..VLAAQRVWNArrngadldqnmepaala...aslpaapawappdppadgD...............PDEDFAAEVTH.......HANR.VAAYNELLDRMGLRPVETAEQVLDLMVTIGLVHIDEHdd.qqPMRLTV.DPPLPTEALDMTPEERSAED.............R.............M..R...WRSRHARLAQKV.LRLFIDP..ASSDlarTTVPATLSRLA.NTTGAEPEDVRHAVQVLLdd............gdfAAHR--FG...VP.....VDLERVHHRERFDLVVDPERFDRMHVH-l..................................
A0A6V8KXL2_9ACTN/20-248              wirwlpcsfafltvvpdqerfrrsawsmlpwdkpvwcdpgsvddwvvqaqryhprreadhaelhardhy----------------..----.-...----.....---------..----------......................................-...............----------Drv..vrvRAAR.VELFTEMCLRRGLPVPHTLDELLACLVGFGLFEM-DG.....EWLLPR.LDQNPVDVLPLVGEEVVNEH.............R.............A..QqddRTVLVAITVREL.AEHSRPR..WRR-...RLVETDIGALA.GALRMPVEEIRRALTQLG.................EIAGLVVE...P-.....---APAVAQDRVRITVTWPAFA------rlf................................
A0A7K2FHY1_9ACTN/14-263              ....................................................................l-VVHNDWWASGWEHVL..PR-Q.G...FPLM.....MLIGTASQP..GFAGSLDDLLremfdghwrmfggg..........ldgaltfswpdeewD...............EEEAPEGREAS.......EASR.WKDFGALLTAAGYPVPATVRDLSELYLAWGLASREETpe.gtRWSMPA.VLPLPGDLLPLDAGLTRRLD.............R.............M..R...WSMRTEPLVTQL.VNHLVDQ..LGEP...REILTSLDRLA.AATGQDAEDLRLAVAALVas............gdaRVLRGQEP...A-.....-DAERLETHQRFCLVMDWNHFHETHT--rl.................................
D3QAJ3_STANL/9-247                   ....................................................................t--LRSDWDRTGWSRFL..PFEG.E...VLWH.....VFCD-ATQW..GIDGDIAVLF......................................Dwqe........smhpVLSPGAGEREWlpe.prrRRPP.RRVIARLLADSGEEYPTTVGEVAELGVSLGLYRRENDgt.tvRWRVPA.ALPLPTEVLPMTLRQRRVED.............E.............Y..R...WLLGGAEIARDL.AEYLVDC..GEA-...PESVTSVRHLA.DSLHCEPDSVRHGLEYLCaplag......gafirvY-------...--.....----------------------------lgngsrrrrqvsperldvddpcvivpqwrklwkrf
A0A4S8PBV9_9ACTN/72-267              .................................................wiaeasehhlgasaevieke----------------..----.-...----.....---------..----------......................................-...............AREEYDRATAE.......RSER.IDTFTTHCRRAGLPVPHTVRDLLEFLLALGLYRSETRd..gkHLVAPQ.LYINPFDVLAFDKVEAIEEAadqrgdleeltaiA.............I..R...RVGGVDYEFDEE.GRFVLPG..NAKS...ATVTVSLAALA.EDAGVPAPVIRGMLMELA.................--EDGDVS...GS.....VDLGEVGLQDDFSLT-------------asdd...............................
A0A3G8ZJ74_9ACTN/41-289              ...................................................................eg--IFDEWLALGWFSIA..PS--.-...VLFS.....ITEAARGLH..FTRAELAESIalnieehgyrel..............dsdplwlvadpeT...............AADLELAEEGGydaylegERTQ.RANWGELGSRSPKLAVTTVDEFIDLLCDWNLLVESDG.....VLELLD.PVPDPVDLLPLTNPEKDELL.............E.............S..R...EPSDFELVDGVL.HAFIYHS..DES-...-TMVTTIGKLA.QQADVAPEMARLILAGIIasg..........esglTADRFGPM...EA.....EAITDLADHQKFTLVVDRDSDAIKHHA-h..................................
A0A1W2F9R9_KIBAR/168-377             .......gwdtvigshawelpyivsqagdqdgatiddvaawavahhrpadwlderlfpvpapalptgha----------------..----.-...----.....---------..----------......................................D...............LDEQATQSRSSri...aeAAAE.EAKLASYAAQLGVPAPTTRRGLLTFFVAAGLVTYDGR.....KYRRVS.SPPLAREVLRLPADLVTQLA.............M.............Q..S...DRRQYQSFATDI.ASVAAWL..DGR-...---AVTVGWLA.DQLLATQEEVRATLHYA-.................--------...--.....----------------------------qtqamlevtgdtelr....................
A0A5J6HGF9_STRAD/14-263              .....................................................................MAMHNDWWVSGWEHVL..PR-Q.G...FPLT.....MLIGTASQP..GFTGSLDDLLqeifdgrwdmig.............gnldgpltfswpdEewd.........yeaAPEGREACEAA.......---R.WEQFSTMLTTAGFPVPNTVRDLSELYLTWGLARCEETpd.gtRWSMPA.VLPLPGDLLPLDPELTLRLD.............E.............I..R...WMMRTGPLLDTL.IDHLVDD..LGEP...AETLTSLDRLA.AATGQDVDDVRLALAELVks............gdaRVQRAAEP...A-.....-DAERLEAHRRFRLVMDWEHFHDNRIQV...................................
A0A1S1V5I0_9FIRM/3-215               .....................................................................IEIPRQIGDYLWTRYL..PEST.Y...KTY-.....VLIGYLNNR..ELSAEDYSEE......................................-...............LMNVGLGEDKT.......LEKV.VAEKRKVLEKLGIEYPENRTEDVALLKQFGLIEAVDG....gKYKYVE.EIKRPEEVLDLDEEEKSALE.............D.............I..K...FEVKHDRAINMI.LSLVLTN..GKL-...--LDCTVEHIT.NMTKVKIADIRTVLDFLV................nKEKSLRVQ...SS.....KDISKLKKGDRVRITVNEEVFNEKRFI-l..................................
A0A8J2VBP4_9BACL/20-184              ...................................................................ip--IPPGLFDYFWLRYI..PEAT.F...SMIQ.....PILVQIARG..STREEIIRHVenkfrke.......................arpvcfnfEqq...........efANELEKEEYEI.......TRSK.EEKIRHVLAQNELTYPVTVEDSISLLFRLGILVETERde.krLVDMVYhPFPKPQDVLTFEPAQLRRLE.............K.............L..Q...SGEETENEADAL.M------..----...-----------.------------------.................--------...--.....----------------------------ta.................................
A0A1Q9LMS7_9PSEU/29-256              ................................................................ellvn---------GGWVRFL..PPGV.H...AVLH.....PFCRA--RE..VTADEVAAAVlatgepwgevdlf...........taedfdemcarsplDesg.........grtVEQVNAGILAD.......HEQR.LAEVDGYAAQLGVAAPCTVGRALDYLVACGLLQRRGE.....RYRLNL.DPPDPSEVFELGEEARAWLR.............D.............CacR...QRWQVASAVMRL.AEDPAGP..LGR-...--GWTTLRGLG.AHLATDIRTVRGALVVLL.................--DDPDAV...FD.....VDPDRVGEDQRFSFR-------------r..................................
A0A0M8WJB8_9NOCA/35-275              ...................................................................sy--MRTAWSNSAWPRLM..PQ-E.A...MNLE.....VVIDTASVL..SQDGDLAHLVtth................................pasNqfpngi...ntvltwQDNDDDGETAM.......LRRHaEAAFTAAVTALARPVPTTVADLADLLADIGVFEHTHTengteQWRAPL.EIPDPMDALPLPADWIDREE.............R.............I..G...WRTRTAGPAMAL.RRSLRAY..EGR-...PQVDTTLQRLA.GEADMPVSAVRAGLDGLMyrf...........gvsVLRQGTTL...DR.....RDLDALAEHARIGIVVDWTSFT------stt................................
A0A1Q9LCB7_9PSEU/14-268              ...................................................................gl--FREVFDGLGWGRFV..PHAA.V...EVLGv...vVMLGCPTRD..QV-GRLVGRTpdaraglaapaweefep...wtetslstaldgeppsplD...............VDRANAEDRAW.......LDRT.IADVDRYADSLGVTHPRTTADVLDYLTACTVLLATTErg.evHYELNP.WAALPAEVLPLTRDQVREED.............A.............L..R...WIALHRPVVRKL.IALFGPY..TDTP..iDALRTTLLDLA.ERCAADVESVRAAVSILA.................--EQPDFC...VK.....GNPERLAAGDLLEIRVDWANFIEYRLDI...................................
A0A0A8F2A4_9ACTN/103-360             ....................................................................l-SLHNDWFPSGWMHVL..PRHH.A...LLLT.....MLFGTATVR..QLRGNLDTLAvqvfgdepgrgisafgd...egldspllwledddleyaE...............SPEDAAQIRAD.......AEEH.QAWFEAALRAASLPVPSTVRELAAVMESFGIVQQSEG.....RWSVPY.HLPRPENVLALPDEILARLQ.............S.............L..R...RHLTIEPAKQAL.LSYLADS..LGYP...AAVSTSLDRLE.RATGCSVDELREALDYLAdee..........dygtKLLRGDPA...IP.....VRARDLAVHARFQICMDWQQINENTIN-v..................................
A0A7X1LUP4_9ACTN/16-250              ..............................................................lhlrsvv--------RGGWLRIP..PNMT.G...LLL-.....IGLGCEGRP..LTREEARTIVrtwanprgd....................wqascwdqeD...............KLERDEDDLAD.......LRKQ.QADAARYAAHYGLPPLRTFTDLLGLLIAAGVVHEIRDargvpRLHPAF.PLPGPHEVFPLDEEELAVQK.............S.............L..R...RDAAYGSDSYRI.IDLFAPT..GERR...NEIITSLDRLA.RTIEGHSHDAREAVQLLL.................--EAGDFS...AT.....EDISCVASHKVFRLHCDWRKFDAQRIGI...................................
A0A1Q4VM42_9ACTN/16-272              ....................................................................l-CMHNDWFESGWPHVL..PSHQ.A...MWMA.....MLFSTATVR..QLEGDLDTIAvqvfgddpgrtp..............rglgdqglespvAwldee....sleaagSQEEAAEITED.......ARVH.RRRCEESLRAAGFPVPATVRELAAVMERLGITHRSGG.....YWSMPD.RFPRPEDVLPLSGEIADSLL.............G.............L..R...KFQAVDPVERAL.LDYATHT..LGSP...AQFSTSLQRLE.RATGFDADELRAALDHLVsrd...........geiQLHRGQPP...AV.....IAAKDLTVHSRFQITLDWAGIDEARS--pv.................................
A0A7W7Q6R7_9PSEU/204-338             .................................................rsttwldeplpapgpheldp----------------..----.-...----.....---------..----------......................................-...............-----------.......----.----ADVARQVGCPVPATLGGMLDLFVAAGVLADDG-.....GYREPS.VTPNPEDVLELPVERRSRLI.............E.............Q..R...DLDRFRSFAADL.VSVVMWG..GTE-...----QTLAGLA.ERTLVAREDVRATLE---.................--------...--.....----------------------------waargdllhi.........................
A0A6V8K2X3_9ACTN/14-226              ............wirwlpcsfayltvvpdqhgfsrkawsmlpwdkavwcdpgsvddwvaqaqshhprre----------------..----.-...----.....---------..----------......................................-...............ADHAELQAREHydrvvrvRAAR.VELFTEMCRRRGLPVPHTLEELLSCLVGFGLFEM-DG.....EWLTPR.LEQNPIEVLPLAGNEIVDEE.............R.............A..QqddRTVLVAITVRAL.AERTRPR..WRR-...RQVTTDLRAFA.AALRMPEGEVRRSLARLV.................EVAGV---...--.....----------------------------hvhprrspla.........................
A0A561BPJ4_9ACTN/230-364             ..............................................................rdgyptl----------------..----.-...----.....---------..----------......................................-...............-----------.......----.----AEIAAQVGRPEPTSRREMLTLFVALGVLTFDGT.....RYAGIA.EPRPAQQVLDLPADVVTYLD.............A.............H..R...ATVQYTGFAADL.VSVALWG..GTE-...----QTVASLA.TRTLASEDQVRRALQYAE.................--------...--.....----------------------------srnllqidrrsgdrlalta................
K0ATS6_GOTA9/7-199                   .....................................................................IKVPGEISEYLWTRYL..PETT.Y...KVY-.....ALIAYLNKK..RA--------......................................-...............ILDAQIEIENN.......IPRV.IQEKKDILNKLGFKYPENRQEDIDLLLKYNLIEMSKDedgedIYVHVY.PIKRPQEVLNIDEEELKTLD.............N.............I..K...FEIKHEQALNML.FTLILNN..NGK-...--LTCSVDHIT.KTTKVKLTEVKEVMNYLL................sEEGSIKVT...GN.....KDIKKLKKT-------------------iky................................
F3NBV3_9ACTN/1-87                    .................................................................mhhh----------------..----.-...----.....---------..----------......................................-...............-----------.......----.-------------------------------------.....------.-----GDLLRLDADLAQRLD.............R.............M..R...WTMRTDPLVYGL.IGHLVDD..LGGP...EEILTSLDRLA.DATGQDADDVRLALAKLV.................RSAR----...--.....----------------------------gaghggsar..........................
A0A4R6IWG0_9ACTN/232-360             ................................................................nypsl----------------..----.-...----.....---------..----------......................................-...............-----------.......----.----AEIAAQVGLREPRSRRELLPLFVALGVLTFDGS.....RYVGVE.RPPMVQDVLELPAAGVANLE.............A.............Y..Q...VTGQFTGYAADL.VSVALWD..GAE-...----QSIESLA.ARTIGSEDDVRGALQFAE.................--------...--.....----------------------------grgllridhqpedqf....................
A0A1I3NE84_9BACL/16-175              ....................................................................v-TLPPDFLQNGWNLFL..PKGT.I..sILLS.....VMTYILQGY..TKEEILE-WMkmeeke..........................lslspfDftl........pfvcKSEEEKQA--Yl.....nIARQ.ERKICKILERSGYAYPKTIDEWIELLIQLKIVQEVKMde.aiYLDVVLePFPHPEDMLKLTPDERKKLE.............K.............Y..R...LNQHMQQ-----.-------..----...-----------.------------------.................--------...--.....----------------------------lse................................
A0A1M5SR25_9ACTN/14-263              ....................................................................l-AMHNDWWASGWEHVL..PR-Q.G...FPLT.....MLIGTASQP..DFTGSLDELLqelfeghwdmiggd..........ldgaltfswpdeegD...............YEEAPEGHEAN.......EAHR.WETFGAMLTAAGYPVPRTVRDLSELYLTWGLARREETpd.gtRWSMPA.ALPLPGDLLPLDADLAKRLD.............R.............I..R...WTLRTGPLVDGL.INHLVDD..LGEP...QEILTSLDRLA.AATSQDADDVRIALAELVqs............gdaQVQRGQEP...A-.....-DAERLEVHQRFRLVMNWDHFHENRVQ-l..................................
A0A373D9N6_9MICO/9-262               ....................................................................q-TVTDILFGRGWSSTL..PPAV.V...ILFGe...lASAGPITRT..ALDSMLRAENphtpdgldssvwepl.......epwteeklaeldedfgEpde.........srtADELNAQDKAQ.......RELD.QADFARYLASKNLPVSHTFGALVDLLVSCNVLSANEA....gGLFLNP.HAPLPAEVLPLDAREAARQD.............K.............I..R...WERLHERTAQAI.IRFFRTD..EQEV...DHILVSLDQLA.KELESDPEDVRSAVKVLT.................--DEGDFS...TS.....IDIERAHPQQSFVLHVDWDVFNRNRIHV...................................
A0A5J6FJ68_9ACTN/14-263              .....................................................................MAIHNGWWPSGWEHVL..PR-Q.G...FPLT.....MLIGTASQS..GFTGSLDDLLqeifdgdwhmiggd..........ldgeltfswpdgewD...............YEDAPEGREAS.......EAKR.WKSFGAMLTAAGFPVPATVRDLSELYLAWGLAYREETpd.gtRWTMPA.VLPLPDDLLPLDAELTRRLD.............R.............A..R...RTTYTGPLVNAL.ITHLVDD..LGEP...QEVLTSLDRLA.VATGRDADEIRLALADLVes............gdaRVRRGQEP...A-.....-DPERLEAHQRFRLAVEWEHFDGPRT--hl.................................
A0A3N2PEV3_9ACTN/12-205              ........................................pgsveewvaraqrrhggrdaahaelhare----------------..----.-...----.....---------..----------......................................-...............----------HyawmvrvRATR.IELFAEMCRRRDVPVPHTVGELLLCLARLGLFEVTDEgd.gdPWVRPR.LDRDPLDVLPLSPRERE--L.............E.............L..R...AQRDDQAVLVAIaIRRLAQR..TRRRwrrRVVTTSLPNLA.NAAGVTVEQARRSLDDLA.................EFTGLGVT...P-.....-----ARSAEALRL--------------tvpwpdfrlrf........................
A0A6F8XK34_9ACTN/14-243              ............wirwlpcsfayltvvpdqhrfsreawsmlpwdkavwcdpgsvddwvaqaqrhhprre----------------..----.-...----.....---------..----------......................................-...............ADHAELHAREHydrvvrvRAAR.VEQFTEMCRRRALPVPHTLEELLYCLARFGLFEM-DG.....EWVTPR.LEQNPIEVLPLTGDEIVNEE.............R.............A..QqddRAVLVAITVRAL.AERTRPR..WRR-...RQVNADLSGFA.AALRMPEAEVRRALTRLG.................EIAGLQVN...PP.....PA----VARDRVRITVAWPSFARR----fp.................................
G2GML9_9ACTN/1-133                   ...............................................................larree----------------..----.-...----.....---------..----------......................................-...............-----------.......----.------------------------------------Tpd.gtRWSMPA.ALPLPGDLLPLDADLAQRLD.............G.............I..R...WTLRTGPLVDEL.INHLVDD..LGEP...QEILTSLDRLA.AATGQDVDDVRLALAELVks............gdaQVQRGEEP...A-.....-DAERLEAHRRFRLVMDWEHFHEKRIQV...................................
A0A7K2XMQ1_9ACTN/14-263              .....................................................................MAMHNGWWETGWEHVL..PR-Q.G...FPLT.....MLIGTASQP..GFTGSLDDLVeeifdghwrmlggd..........ldaaltfswpdeewD...............YEEAPEGREAS.......EADH.WETFGALLTAAGFPVPTTVRELSELYLAWGLAYREETpq.gtRWSMPD.ALPRPGDLLPLDAELAERLD.............G.............I..R...RTMRTGPLVGGL.IRHLADD..LGEP...DETLTSLDRLA.VATGQDTDDVRLALAELVrs............gdaRVRRGQET...A-.....-DPERLEAHRRFRLIMDWDHYDETRTQ-l..................................
A0A1X9MEI4_9BACI/20-169              ...................................................................vp--IPNGFMHNGWGAFL..PPTA.I...VFLV....eVMNYAYEGL..DAEGTIKAIEdyhyp...........................lakkknDqlff......nfsqgVDDIRGKKKRElf..leeLESE.T-ERKKVLEQSGYYYPQTIRECIELGEKLGMIQRFKKeg.tdYYDVTInPFPHIKH-------------.............-.............-..-...------------.-------..----...-----------.------------------.................--------...--.....----------------------------ylkgdeverw.........................
A0A5Q2N311_9FIRM/22-146              .....................................................................IRIPSTFYEYNWPHYL..PPTA.L...SLYR.....ALCRIAET-..DLRGSRARYEl....................................yD...............RPFTPWHAENT......eIEIN.QWLLQKLCERKGWTFPANVTQSVDLLLKLSLIQVQVDeqgdeVYDIIL.PVPHPADILE----------.............-.............-..-...------------.-------..----...-----------.------------------.................--------...--.....----------------------------rpelr..............................
A8MK06_ALKOO/5-220                   ....................................................................v-RVPQEIHSYLWTRYL..PETA.Y...KTY-.....ILIGYLQQE..NKTGKVAMDF......................................-...............LLNANIKEENT.......IPQI.LQEKKDVLKKLGYEYPKNIKEDLDLLLSFQLIMEVADskgdtYYIQSI.PVPKLEEVLKLDDEEIKNLK.............N.............I..R...FEIDNQKGMDMI.LTMLLNG..NGN-...--LGVTLDYIY.KTTKVKLTEIRAVLSYLV.................DEGSISIR...AN.....KAIDKLKKEDKLLIQINEAVFHQKRVV-l..................................
W7IXG0_9PSEU/14-268                  ....................................................................g-VFRDVFDGLGWSRFV..PHAA.V...EVLGv...vVLLGAPTRD..QI-GRLVGRTpdavvglsgpawdefep...wtehtlrtaldgaaptpgE...............VARANAEDRAW.......LDGL.IAEIDSHADALGVFRPRTLSDVLDYLTACTVLIATGRdg.dtRYELNP.WAMLPAEVLPLTRDQVDEED.............A.............L..R...WIGLHRPVVRKL.IDLFGPY..ADAP..lDVLRTTLLELS.RTCGVDLESTRAAVTILA.................--DQPDFE...VT.....GDAERAEPGAELEIRVDWANFLEYRLDI...................................
A0A1A5XK34_9BACL/14-239              .....................................................................VVIPSGYTANGWYNVL..SHDM.N...VLFQ.....ALCYVVTKC..ESKEEMKKQLdgfkg...........................lqhvfsT...............PKKEKFKSEEDy....naYVAH.VEKHKEFLERSGYQYPTSREEAIELLTKWGLVLDKGD.....VWDIPVyPFPDTMDLFQLTEAEQFALT.............H.............I..K...LEALVHPMFSRL.VLKLHEH..EENT..fTYTKAELKEML.NTNDAMLTEVLIKLTPYM.................------EE...PI.....DNLLEIPDDQPMTFTVVWERIYEDFLG-q..................................
A0A2W2D186_9ACTN/93-221              .................................................................lced----------------..----.-...----.....---------..----------......................................-...............-----------.......----.-------LSELGVPAPTTRPELLRFLVAAGVVIAETSgg.vtRYRLPE.QPPRAEDVLRLPDERRAVIR.............R.............Q..D...ARRRYTRFVADL.AAVAVWS..RDH-...-TVSATPAELS.GRMLATEEEIRETIA---.................--------...--.....----------------------------hgiehgllspsgega....................
A0A853ABF1_9ACTN/4-268               ...................................................................dv---YQDWFRNGWDAVM..PPGA.Y...SVF-.....MSCSYVTDAeaEIDGDLTEYFdlstcfpr......................spqyphgwEtlvdwg..envrprsPFEDPASVEREr....rrMRDR.RELFEQAMAGAGLPCPQTLRELVRLMTDWGLIEPYPLap.gvLWRLPP.ALPYPDQVLPLPESLTSWME.............E.............Q..R...WVALMNPVIDRL.LDYVGHF..LDFP...DEMPVSLDLLA.ACIDEDVPSVRQAMVVWQgqgqis....aerhcpcGASGPQGR...CP.....VNLERVPSNRRFLLLPDWMSILRDRA--gl.................................
#=GC seq_cons                        ....................................................................h......h...uW.thl..P..........h......hhhhhhtt...thttphtthh......................................t...............h.ct..ttptt.......h.tp.hpphpphhpptGhshPpThc-llcLhlshGLhttpps.....taphsh.shPhPt-lLsLsscthtthc.............p.............h..+...hphtht.hhttl.hphhh.p...tp......hhsolppLu.ttht.t.pplRhslt.hh....................................t..th..tp.h.h..............h..................................
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