#=GF ID   DUF6087
#=GF AC   PF19565.3
#=GF DE   Family of unknown function (DUF6087)
#=GF AU   Williams LS;0000-0001-5551-8526
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Fragoso S;0000-0001-7018-3891
#=GF SE   Manual
#=GF GA   27.10 27.10;
#=GF TC   27.30 28.20;
#=GF NC   26.70 23.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   16766657
#=GF RT   Amplification of the entire kanamycin biosynthetic gene cluster
#=GF RT   during empirical  strain improvement of Streptomyces
#=GF RT   kanamyceticus.
#=GF RA   Yanai K, Murakami T, Bibb M;
#=GF RL   Proc Natl Acad Sci U S A. 2006;103:9661-9666.
#=GF DR   INTERPRO; IPR045733;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents a member of a biosynthetic gene cluster
#=GF CC   (BGC). This BGC (BGC0000703) is described by MIBiG as an example
#=GF CC   of the following biosynthetic class, saccharide. This family
#=GF CC   includes a  protein from the kanamycin biosynthetic gene cluster
#=GF CC   from  Streptomyces kanamyceticus [1]. 
#=GF SQ   87
#=GS A0A7K2TLW2_9ACTN/21-91    AC A0A7K2TLW2.1
#=GS A0A0F2TE08_STRR3/4-112    AC A0A0F2TE08.1
#=GS A0A561SFP6_9ACTN/1-95     AC A0A561SFP6.1
#=GS A0A2A4KQK9_9ACTN/1-97     AC A0A2A4KQK9.1
#=GS A0A1H5EL48_9ACTN/1-36     AC A0A1H5EL48.1
#=GS A0A0G3A8G6_9ACTN/1-99     AC A0A0G3A8G6.1
#=GS A0A2S4YFT8_9ACTN/1-105    AC A0A2S4YFT8.1
#=GS A0A345SZV2_9ACTN/1-97     AC A0A345SZV2.1
#=GS A0A1H5NCJ5_9ACTN/1-95     AC A0A1H5NCJ5.1
#=GS A0A7K2YTL6_9ACTN/1-101    AC A0A7K2YTL6.1
#=GS A0A3M8F2R9_9ACTN/21-93    AC A0A3M8F2R9.1
#=GS A0A0W7WWE7_9ACTN/20-102   AC A0A0W7WWE7.1
#=GS A0A1Q4WLM6_9ACTN/1-99     AC A0A1Q4WLM6.1
#=GS A0A1Q4WGW5_9ACTN/7-101    AC A0A1Q4WGW5.1
#=GS A0A059WC71_STRA9/1-96     AC A0A059WC71.1
#=GS F2RKN4_STRVP/1-94         AC F2RKN4.1
#=GS A0A5R9M632_9ACTN/2-101    AC A0A5R9M632.1
#=GS A0A1Q5LAW1_9ACTN/20-97    AC A0A1Q5LAW1.1
#=GS A0A561TWN9_9ACTN/4-102    AC A0A561TWN9.1
#=GS A0A7G1P6N5_9ACTN/21-93    AC A0A7G1P6N5.1
#=GS A0A3A9ZER7_9ACTN/21-96    AC A0A3A9ZER7.1
#=GS A0A0N0NDW8_9ACTN/21-96    AC A0A0N0NDW8.1
#=GS A0A100Y6H9_9ACTN/1-101    AC A0A100Y6H9.1
#=GS A0A1S2K9T3_9ACTN/1-97     AC A0A1S2K9T3.1
#=GS A0A2G1XE51_STRCJ/1-97     AC A0A2G1XE51.1
#=GS A0A429UMF0_9ACTN/6-96     AC A0A429UMF0.1
#=GS A0A0L0KMC8_9ACTN/1-94     AC A0A0L0KMC8.1
#=GS A0A1Q4V213_9ACTN/21-96    AC A0A1Q4V213.1
#=GS A0A1K2FSQ2_9ACTN/1-94     AC A0A1K2FSQ2.1
#=GS A0A0F2TES4_STRR3/4-103    AC A0A0F2TES4.1
#=GS A0A7M2SJG0_9ACTN/1-95     AC A0A7M2SJG0.1
#=GS A0A6H9UXX5_9ACTN/1-95     AC A0A6H9UXX5.1
#=GS A0A2P8DG42_9ACTN/24-97    AC A0A2P8DG42.1
#=GS A0A0M8QP32_9ACTN/1-99     AC A0A0M8QP32.1
#=GS S3B996_9ACTN/21-94        AC S3B996.1
#=GS A0A2Z4V3Q3_9ACTN/1-103    AC A0A2Z4V3Q3.1
#=GS A0A059WE31_STRA9/1-99     AC A0A059WE31.1
#=GS A0A4R4NHJ0_9ACTN/1-95     AC A0A4R4NHJ0.1
#=GS A0A6I5CC96_9ACTN/1-98     AC A0A6I5CC96.1
#=GS A0A4R9EPL6_9ACTN/4-95     AC A0A4R9EPL6.1
#=GS A0A445NGB9_STRNE/1-99     AC A0A445NGB9.1
#=GS A0A0M8YE43_9ACTN/1-100    AC A0A0M8YE43.1
#=GS V4INJ9_9ACTN/8-77         AC V4INJ9.1
#=GS A0A1Z2KUE1_9ACTN/22-91    AC A0A1Z2KUE1.1
#=GS A0A7W7U7A6_9ACTN/1-94     AC A0A7W7U7A6.1
#=GS A0A101NU70_9ACTN/1-99     AC A0A101NU70.1
#=GS A0A1T3NMY8_9ACTN/2-105    AC A0A1T3NMY8.1
#=GS A0A1W7D0F6_9ACTN/20-89    AC A0A1W7D0F6.1
#=GS A0A059W689_STRA9/1-96     AC A0A059W689.1
#=GS A0A4R4T7D8_9ACTN/1-96     AC A0A4R4T7D8.1
#=GS A0A7K2ZAG8_9ACTN/1-86     AC A0A7K2ZAG8.1
#=GS A0A3G2JGW4_9ACTN/1-94     AC A0A3G2JGW4.1
#=GS A0A4Q9HW26_STRKA/21-94    AC A0A4Q9HW26.1
#=GS A0A0N0XWU1_9ACTN/1-100    AC A0A0N0XWU1.1
#=GS A0A221P081_9ACTN/2-105    AC A0A221P081.1
#=GS A0A6N7L3P8_9ACTN/2-99     AC A0A6N7L3P8.1
#=GS F2R865_STRVP/1-100        AC F2R865.1
#=GS A0A1X7CVZ2_9ACTN/1-105    AC A0A1X7CVZ2.1
#=GS A0A022MJA8_9ACTN/1-96     AC A0A022MJA8.1
#=GS A0A1E7NEP6_KITAU/1-71     AC A0A1E7NEP6.1
#=GS A0A7W7U3A5_9ACTN/1-100    AC A0A7W7U3A5.1
#=GS A0A540W0G3_9ACTN/1-95     AC A0A540W0G3.1
#=GS A0A2A3HSZ1_9ACTN/4-104    AC A0A2A3HSZ1.1
#=GS A0A561ERV2_9ACTN/4-101    AC A0A561ERV2.1
#=GS A0A3S8WW02_9ACTN/1-105    AC A0A3S8WW02.1
#=GS A0A7W7RAK9_KITKI/5-101    AC A0A7W7RAK9.1
#=GS A0A7Y7BAX9_STRMO/4-80     AC A0A7Y7BAX9.1
#=GS A0A4Q9HQ87_STRKA/1-97     AC A0A4Q9HQ87.1
#=GS A0A160NY78_STRLU/1-94     AC A0A160NY78.1
#=GS G2G6K4_9ACTN/1-96         AC G2G6K4.1
#=GS L1L3F1_9ACTN/20-89        AC L1L3F1.1
#=GS A0A3N6FFH2_9ACTN/1-104    AC A0A3N6FFH2.1
#=GS A0A176L6B0_9ACTN/4-104    AC A0A176L6B0.1
#=GS A0A1Q4USF7_9ACTN/1-93     AC A0A1Q4USF7.1
#=GS A0A6G2VTD1_9ACTN/1-100    AC A0A6G2VTD1.1
#=GS A0A7U3UWJ2_9ACTN/20-96    AC A0A7U3UWJ2.1
#=GS A0A6H9UPX1_9ACTN/21-95    AC A0A6H9UPX1.1
#=GS A0A2W2LXR3_9ACTN/21-92    AC A0A2W2LXR3.1
#=GS A0A7Y5XDP3_9ACTN/1-87     AC A0A7Y5XDP3.1
#=GS A0A2L0NEE5_9ACTN/2-97     AC A0A2L0NEE5.1
#=GS A0A0G3UZG7_9ACTN/1-96     AC A0A0G3UZG7.1
#=GS A0A2M9JEU1_9ACTN/1-98     AC A0A2M9JEU1.1
#=GS A0A345T391_9ACTN/4-101    AC A0A345T391.1
#=GS A0A1H7NPB4_STRJI/11-86    AC A0A1H7NPB4.1
#=GS A0A101NL57_9ACTN/1-95     AC A0A101NL57.1
#=GS A0A2Z5K466_9ACTN/117-206  AC A0A2Z5K466.1
#=GS K4R937_STRDJ/21-100       AC K4R937.1
A0A7K2TLW2_9ACTN/21-91               .................taddplavcn---.----------KRRRPP....TGTYRRHRPAQGG-.-AARLRPQEPRTLEPWDGFM..YEATGTAPDLAAARKRM------......---.----..........----.------------ssiadt....
A0A0F2TE08_STRR3/4-112               ..........................d-ED.ESLAEWAARREQRRRP....VGKLRAVRLADGQR.VGAHVTPDEPRLIMRWDGYQ..WLPDAVVEDYAAAQRALYGVEGD......GVV.RSDGstpghptpghPT-PgRPDKAPGRHRKP..........
A0A561SFP6_9ACTN/1-95                ...........................MDD.EPLSEWAERRDAR---....IGQLRAAPISTGDGpKGSHLNPGVPRAIERWNGHT..WEPFAVAANLAEAQRILFPGAQD......PPV.SAPV..........--PN.PLGPGTGRHRKP..........
A0A2A4KQK9_9ACTN/1-97                ...........................MDE.EPLSEWAERRDAR---....IGRLRAVLIAPREGpQGAHLNPDAPRTVERWNGHT..WEPYAFAADLAEAKRILYPEGRV......LPP.PAPG..........PVRQ.PLAPGKGRHRKP..........
A0A1H5EL48_9ACTN/1-36                ...........................MDD.EPLKDWADRRDAK---....IGRLRAVSVVPGD-.KVAAV---------------..-----------------------......---.----..........----.------------rp........
A0A0G3A8G6_9ACTN/1-99                ...........................MYE.EPLEEWARRREERRNA...sKGKLRAAPLTSGPH.RGTHVEPSAPRAIEEWNGVQ..WVTVGIVPDLAAAKALLYPPPAV......EEK.PAEW..........GR-P.ALGRGRGRHRKP..........
A0A2S4YFT8_9ACTN/1-105               ...........................MDD.EPLEQWAARREQRRPA....PGERRAMPLGDDSE.RGSHVGPDAPRGIQEWDGHQ..WAPAGIAEDFTTAAAETGEDAMAr....aERV.PLPKfg......klPARP.EPWRPTEVFRRP..........
A0A345SZV2_9ACTN/1-97                ...........................MDD.EPLSEWAERRDAK---....IGRLRAVPLVSGDGpQGSHLNPDAPRAIQRWNGHA..WEPHGFASNLAEAKRILYPQASE......PPA.SVPA..........PEPR.PLGAGTGRHRKP..........
A0A1H5NCJ5_9ACTN/1-95                ...........................MDD.EPLKDWAERRDSK---....IGRLRAVPVVSGDGpKASHLNPDAPRAIERWNGHT..WEPYGFVANLAEAKALLHPEVNE......PT-.-LTG..........PVPK.PLGSGTGKHRKP..........
A0A7K2YTL6_9ACTN/1-101               ...........................MDD.EPLEQWLERRDARREE...sRGRRKAVPLGEGPW.RAEHVNPRAPRLIVEWDGYA..WQAVTVADDLAQARKILYPGAQA......AAIpPPPQ..........PGAP.GPGPGRGRHRRP..........
A0A3M8F2R9_9ACTN/21-93               .........................da--D.DPLAAYNKRRRPPMDL....Y--RRHRPVHGG--.-AGHLRPDEPRVLEEWTGFA..YEVVGTAPSLAAAQE--------......---.----..........----.------------wgnelqigdd
A0A0W7WWE7_9ACTN/20-102              .......................tddg---.DPLAAYHKRRRPPLDV....--WRRHRPLHGG--.-GGHLRPEGPRVLEEWNGFL..YEPAGTAANLAEARRWVSEQASG......S--.----..........----.------------tdgpvgeyrn
A0A1Q4WLM6_9ACTN/1-99                .........................md-EE.EPLASWAARREQRLRP....VGQLRVVRLTVGRQ.RGAHVLPGEPRLIVRWDGYQ..WLPETVAEDYATAQRILYGAEGA......GA-.PRPG..........RQAR.RPGKAPGRHRKP..........
A0A1Q4WGW5_9ACTN/7-101               .........................pp--E.ESLEQLAARQAKAHRD...lAGQLRVLVLAPGPQ.RAAHLHPKAPRLVLRHDGYQ..WTPLMTATDYAAAQQLLHGPPPI......PP-.----..........PAGP.ARTGSRGRHRKP..........
A0A059WC71_STRA9/1-96                ...........................MDD.ESLSDWASRRAAK---....VGRLRAMPIVFGDGpRAAHLNPDAPRAIERWNGHT..WEPHGFAANLAEARRILYPDANT......DPA.PAPL..........PR-Q.PMAPGKGGHRKP..........
F2RKN4_STRVP/1-94                    ...........................MDD.EPLSQWAERRDAR---....IGQLRAVPLVTGDGpRASHLNPDAPRAIQRWNGHL..WEAHGFAANLAEARRILFPHAEA......TAT.PEA-..........--SP.KLGPGTGRHRKP..........
A0A5R9M632_9ACTN/2-101               ..........................q-NE.EPLEEWARRREERRNA...sKGKQRAVPLAEGPS.RGAHVDPGAPRVIQEWTGTE..WVAVGVADNLAAAKVLLYAAQPV......EED.PVEW..........DRPP.GLGKGRGRHRKP..........
A0A1Q5LAW1_9ACTN/20-97               .....................vdagdp---.--LAAYEKRRRP---P...lDVHRRHRPLHGG--.-GGHLRPDEPRALEEWNGFS..YEPAGTAPNLAEAQRWVNGIAPG......T--.----..........----.------------aaaae.....
A0A561TWN9_9ACTN/4-102               ..........................p-DD.ETVTDWYSARANRERP....PGVRDALTLDPTTR.RGGALFPDTPRLVVEWDGQS..WQPVGVADTYADAYPMIVRRGED......FAP.PQDD..........TPVA.LLRKGSGRHRK-s.........
A0A7G1P6N5_9ACTN/21-93               .......dadnpfaaydkrrrppmdiy---.----------------....---RRHRPVHG---.GAGHLRPDEPRVLEEWSGFA..YRPVGTAPSLAAAQGWV------......---.----..........----.------------selqigdd..
A0A3A9ZER7_9ACTN/21-96               .........................da--D.DPLAAYNKRRRPPMDT....Y--RRHRPV-HGG-.-AGHLRPDEPRVLEEWNDFA..YEVVGTAPDLAAAQEWVSELQ--......---.----..........----.------------ieddsaa...
A0A0N0NDW8_9ACTN/21-96               dadnpfaaydkrrrppmdiyrrhrpah---.----------------....-------------G.GAGHLRPDEPRVLEEWSGFA..YEPAGTAPGLAAAQEWVNE----......---.----..........----.------------lqvgddpaa.
A0A100Y6H9_9ACTN/1-101               .......................msdp--E.EPLADWARRREERLAE...rRGRLRAVPLVDGPL.RGSHVAPSAPRAILEYDGLA..WVPVMIVANLAEAQALLYPPPPE......PVR.PPEW..........DR-P.ALGQGRGRHRRT..........
A0A1S2K9T3_9ACTN/1-97                ...........................MDD.EPLSEWAERRDAK---....IGRLRAVPIVSGDGpRASHLHPDAPRAIERWNGHA..WEPYAFAADLAEAKRILYPEAST......PPT.PAPG..........PARL.PLAPGTGRHRKP..........
A0A2G1XE51_STRCJ/1-97                ...........................MND.EPLEEWAERREAK---....IGRLRAVPIVTGDGpRGAHLNPDAPRAIERWNGYS..WEPYAFAASLAEAKRILYPEAQT......SPS.TTPS..........PARQ.PLAPGTGRHRKP..........
A0A429UMF0_9ACTN/6-96                ..............rsrltepaasrps---.----------------....--DERCVPLVSGDGpKASHLNPDSPRAIQRWNGYT..WEPHGTAANLAEAQRLLHPRDER......PP-.TAPA..........PEPQ.PLRAGRGRHRRP..........
A0A0L0KMC8_9ACTN/1-94                ...........................MDE.EPLSEWAERRDAK---....VGRLRVVPIVRGGGpRAAHVNPNEPRVIERWNGHA..WEPYGYAADLAEAKRILYPDAEA......---.PAPG..........PVRQ.PLAPGRGRHRKP..........
A0A1Q4V213_9ACTN/21-96               .......dadnpfaaydkrrrppmdiy---.----------------....---RRHRPVHG---.GAGHLRPDEPRVLEERSGSA..YEPVGTAPNLAAAQEWVN-----......---.----..........----.------------elrlgddpta
A0A1K2FSQ2_9ACTN/1-94                ...........................MDD.EPLAEWAERRDAR---....IGQLRAVPLVTGDGpRASHLNPEAPRAIQRWNGHL..WEPHGFAANLAEARRILFPHAEA......PST.PEA-..........--TP.KLGPGTGRHRKP..........
A0A0F2TES4_STRR3/4-103               .........................ad-DDgQSIARWYGARAGRVRP....VGTRDALALGPAP-.RRGALFEDAVCLVVEWDGAC..WRPLGVADGYAEAYTVIVRRGEA......FAA.PQED..........TPVA.LLRKGSGRHRR-a.........
A0A7M2SJG0_9ACTN/1-95                ...........................MDD.EPLKDWAERRDAK---....IGRLRAVPVVPCDGpRASHLNPDAPRAIERWNGHT..WELYGFADSLAEAQAILYPEAND......PSP.S--G..........PVSK.PLSSSTGKHRKP..........
A0A6H9UXX5_9ACTN/1-95                ...........................MDD.EPLKDWAERRDAK---....IGRLRAVPVVPGDGpRASHLNPEAPRAIERWNGHT..WEPYGFAASLAEAQAILYPEANE......PSP.PGT-..........-VPK.PLGSGTGKHRKP..........
A0A2P8DG42_9ACTN/24-97               .........................dp--D.DPLSAFTKRRRPVLDI....YRRRR--PLHGGP-.--GHARPEEPRVLEEWDGFT..YVPAGTAPDMATAQRWADERRP-......---.----..........----.------------agsp......
A0A0M8QP32_9ACTN/1-99                ...........................MNE.EPLEEWAQRREERRAA...aTGKRRAVPLTEGPH.RAAHVEPDVPRVIQEWNGTE..WETIGVAEDLDAAKALLYPLQPV......KDK.PAEW..........DR-P.ALGPGKGRHRRT..........
S3B996_9ACTN/21-94                   .........................da--D.DPLAAYNKRRRPPMDI....W--RRHRPVN-GG-.-AGHLRPDEPRVLEEWDDFT..YQVAGTAPDLAAAQRWVT-----......---.----..........----.------------elvlddds..
A0A2Z4V3Q3_9ACTN/1-103               ...........................MND.EPFERWFARRQARLRQ....PGQLRAITLGVGPQ.RAAHIDPDAPRMIVEWDGFD..WQAVMVVDNYAAACLVLTPSEGR......AAD.QTETtg......pvTGRN.PLAPGTGRHRKP..........
A0A059WE31_STRA9/1-99                ...........................MHE.ESLEDWARRREERRNA...sKGKLRAVPLTEGPH.RGQHVDPNAPRVIQEWTGTE..WETIGTVADLAAAKALLYPPQPV......EEK.PAEW..........DR-P.SLGKGRGRHRKP..........
A0A4R4NHJ0_9ACTN/1-95                ...........................MEE.EPLSDWAERRSRRR--....ADRYRVVTLTPGPP.SGSHVAPEAPRLVSRWNGYE..WEAVAVVANLAEAKRILYPDTAG......TD-.PTPC..........----.--PPAVGRHRR-atpkrr....
A0A6I5CC96_9ACTN/1-98                ...........................MDD.EPLSRWAERRDAR---....IGQLRAVPLVTGDGpRASHLNPEAPRAIQRWNGHL..WEPYGVAANLAEARLVLFPRAEA......DSE.PSPA.........pAATP.RLGPGTGRHRKP..........
A0A4R9EPL6_9ACTN/4-95                ..................dwppelaer---.-----FGRRILARTYQ....PGRLRVVTLGQDPP.RAAPVEPHQPRAVMRWTGKKggWKLVAVVADLAATQAFKCPPRAD......NDQ.----..........----.------------gdvelepepw
A0A445NGB9_STRNE/1-99                ...........................MDE.EPLKDWAQRREADRER...kKGRLRAVPLGPGRH.RGFHVHPQAPRVIEQWDGYE..WTPVTVADDLAAAQDLLHPTDPA......GDP.AGEW..........DR-P.APGKPPGKHRKP..........
A0A0M8YE43_9ACTN/1-100               .........................mr-DD.EPLEEWARRRDGRRAA...sKGKRRAVPLGDGPH.RAAHVAPGAPRAIEEWTGTE..WQVVGVVESLAAAQALPHPPPPE......RAK.PAER..........DR-P.SMGEGRGRHRKP..........
V4INJ9_9ACTN/8-77                    .........drfavydkrrrapmdvwr---.----------------....----RHRPLHG---.GGSHLRPGEPRVLEEWNGFS..YEPVGTARNLAQAQQWVHERDE-......---.----..........----.------------gga.......
A0A1Z2KUE1_9ACTN/22-91               ......addrlapydkrrrppldiyrr---.----------------....-----HRPLHG---.GAGHLRPGEPRALEEWDGFS..FVPAGTAADLAAAQRWVEE----......---.----..........----.------------rlsg......
A0A7W7U7A6_9ACTN/1-94                ...........................MDD.EPLAEWAERRDAR---....IGQLRAVPLVTGDGpRASHLNPDAPRAIQRWNGHL..WEPHGFAANLAEARRILFPRTEA......PSA.PET-..........--AP.KLGPGTGRHRKP..........
A0A101NU70_9ACTN/1-99                ...........................MHE.EPLEEWARRREEPRNA...sKGKLRAMPLTSGPH.RGAHVGPGAPRAIEEWNGTQ..WVTVGIVPNLAAAQALLYPRLAV......EEK.TAEW..........DR-P.ALGKGRGRHRKP..........
A0A1T3NMY8_9ACTN/2-105               ..........................s-ND.EPLEDWAARREQRLRP....VGERKAVHLTGPP-.RASHVDREAPRVVLEWDGYQ..WVTLAVAANYLEAARLLYPSSREevgkdgAA-.---Aah......rtQPGP.YLNEGTGRHRRT..........
A0A1W7D0F6_9ACTN/20-89               ......................vdaad---.-PLSAYDKRRRPPM--....DTYRRHRPIHGG--.-AGHLRPDEPRVLEEWNEFA..YRVTGTAPDLATAQAWTN-----......---.----..........----.------------elr.......
A0A059W689_STRA9/1-96                ...........................MDD.ESLSDWANRRAAK---....VGRLRAMLIVFGDGpRAAHLNPDAPRAIERWNGHT..WEPHGFAANLAEARRILYPDANT......DPT.PAP-..........PTSQ.PVAPGTGKHRKP..........
A0A4R4T7D8_9ACTN/1-96                ...........................MDE.EPLSDWAERRSRRR--....ADRYRVVTLTPGPA.SGSHVDPQAPRLVSRWNGYE..WEAVAVVANLAEAKLILYPETAG......TD-.PMPA..........VPQP.LRRRA-------trkrgdg...
A0A7K2ZAG8_9ACTN/1-86                ...........................MDD.ESLSDWAKRRDAK---....IGRLRAVPLVSGEGpSASHLNPDSPRAIQRWNGYT..WEPYGTAANLAETRRLLHPRDEE......PPT.VT--..........----.------------aprpqva...
A0A3G2JGW4_9ACTN/1-94                ...........................MDD.EPLSQWAERRDAR---....IGQLRAVPLLSGDGpRGSHLNPGAPRAIQRWNGHM..WEPHGFAANLAEARRLLFPRTEA......APA.PEA-..........--AP.RLGPGTGRRRRP..........
A0A4Q9HW26_STRKA/21-94               .......dpsdplapyekrrrppldiy---.----------------....---RRHRPLHGG--.-AGHLRPEEPRALEEWDGFT..YAPAGTAPDLASAVSWVAQTEPE......P--.----..........----.------------rq........
A0A0N0XWU1_9ACTN/1-100               .........................md-DE.ESLAEWARKREQRRAR...nKGQLRAVPLSSGPH.CGAHVEPDAPRVIQEHDGTE..WVTVSVVESLAAAKAILYPPQPA......EEK.PTEW..........DR-P.ALGKGRGRHRRP..........
A0A221P081_9ACTN/2-105               ..........................p-EE.EPLHEWAARRDRRRAAeremTGTRRAVPLADGA-.RASHVAPNAPRALMEWDGQT..WVTVGVAPNADAAREFLGHVPEP......APE.SGPDi........qPAPP.GLGPGRGRHRKH..........
A0A6N7L3P8_9ACTN/2-99                .........................pd-DE.ESLSAWYARREARRRP....IGERRVVSLQAGPS.RGSHVDPQAPRIVQEWDGYT..WQPVSVADDYPAACRAVSALDAA......VAV.PVP-..........-GFN.PLGPGTGRHRK-i.........
F2R865_STRVP/1-100                   .........................mq-ED.EPLEQWARRRAERRAA...sMGKQRAVPLGNGPH.RGAHVDPAAPRAIEEWTGTE..WQVVGIAENLAAAQSLLFPPPPA......QAK.PAEW..........DR-P.SMGKGRGRHRKP..........
A0A1X7CVZ2_9ACTN/1-105               ...........................MED.EPLEEWAERRERRRPT....PGERRAIPLGEQSQ.QGAHVDPDTPRGIQEWDGHQ..WAPAGVTEDLEAAANETGKDTAHr....aERV.PLPTfs......klPSAP.EPWRPTEQWYRP..........
A0A022MJA8_9ACTN/1-96                ...........................MDD.EPLSRWAERRDAR---....IGQLRAVPLVTGDGpRASHLNPEAPRAIQRWNGHL..WEPHGFAANLAEARRVLFPHTEA......EAA.PAPT..........-ATP.RLGPGTGRHRKP..........
A0A1E7NEP6_KITAU/1-71                ...........................MDD.EPLSEWAQRRNRRLRP....VGARRDVTT-----.AAAHVDPTAPRLIQEWDGHA..WVPIALTDEPLTTAV--------......---.----..........----.------------atgpgrhr..
A0A7W7U3A5_9ACTN/1-100               .........................mq-DD.EPLEEWARRRDARQAA...sKGKRRAVPLGEGPH.RGAHVDPGAPRAIEEWTGTD..WAVIGVVESLAAAQAVLYPPPPV......QEK.PAEW..........DR-P.ALGRGRGRHRKP..........
A0A540W0G3_9ACTN/1-95                .........................md-ED.EPLEQWAARRDAMRRP....VGELKAVML-DGL-.AATHVRPTEPRLILCWDGVE..WVPHTVADDYPTAQRILHGIKGD......GMI.PMP-..........--AP.QPRKPAGRHRKP..........
A0A2A3HSZ1_9ACTN/4-104               ..........................p-DE.EPLPDWYSHHADTRHP....VGTRDAFVIGEAPRgTTHPIFQDAPRLVVEWDGSA..WQPVAVADSFAAACQMIAQDGRP......SLF.PQAQ..........SPLP.PDR--SSRWR--pgpdr.....
A0A561ERV2_9ACTN/4-101               ..........................p-DD.ETVSDWYAARADGNRP....PGVRDALTLDPTV-.QRGCLFQDTPRLVVEWDGQA..WQPVGVADTYADAYPVIVRRGSD......FAA.PQED..........TPVA.LLRKGRGRHRR-s.........
A0A3S8WW02_9ACTN/1-105               .........................ma-DE.EPLREWAARRDRRRAAqrqiTGIRRAVPLADGA-.RAAHIAPDAPRALMEWDGQT..WVTVGVAPNADAAREFLGHVPAP......APE.SGWDl........qPAPP.GLGPGRGRHRKP..........
A0A7W7RAK9_KITKI/5-101               ..........................d-ED.EPLEVWAQRRAKRLRP....VGQLKVVTIGHED-.APAHLQQHLPRLVSRWDGVQ..WIPQTIAENYAAAQRILHGIVVD......GVM.RDM-..........MPAA.APRKAPGRHRRP..........
A0A7Y7BAX9_STRMO/4-80                .......................yrrp--E.DPLAAYERRR---LAP....LGEVRRHRPWHGG-.-GSHVRPGEPRVLLEWDGFA..YQVAGIAPDLPAARAWASEAVP-......---.----..........----.------------rqefq.....
A0A4Q9HQ87_STRKA/1-97                .........................md-EE.EPLADYMARRDSR---....IGRLRAVHA-CGPQ.RGEHVDPEQPRLIQRWNGSA..WEVFTMAANLSEARKLLQPADTE......SPA.QEPA.........qPARP.PLAPGRGRHRK-q.........
A0A160NY78_STRLU/1-94                ...........................MDD.EPLSQWAERRDAR---....IGQLRAVPLVTGDGpRASHLNPDAPRAIQRWNGHL..WEPHGFAANLVEARRVLFPHTEA......AAT.A---..........EASP.KLGPGTGRHRKP..........
G2G6K4_9ACTN/1-96                    ...........................MDD.EPLKNWAERRDAK---....IGRLRAVPVVPGDGpRASHLNPDAPRAIERWNGHT..WEPHGFAANLAEAKAILYPESNE......PS-.PLQG..........PVPK.PLGSGTGKHRKP..........
L1L3F1_9ACTN/20-89                   .......................idat---.EPLAAYDRRRRPPLDQ....Y--RRHRPLHGG--.-GGHLRPEEPRALEEWDGFT..FVPAGTAPNLAAAQRWV------......---.----..........----.------------ndfr......
A0A3N6FFH2_9ACTN/1-104               ...........................MSE.EPLEEWAARREQRRPA....VGERRPAPLGDQK-.QGVHVSPEEPRGIQEWDGHQ..WVPVGVAEDSEAAAHETGEEAAA......RAA.RVSLpaf....gklPTMP.NPWRPTEVFHRP..........
A0A176L6B0_9ACTN/4-104               ..........................p-GD.EPLSEWADRRAARLRP....VGERRAVTLGTGPQ.RAAHLDRDTPRMIMEWDGYQ..WVPVTTVDNYAAAQRMLHGISDE......AAQ.ITVTa........gDGRP.PMAPGRGRHRKP..........
A0A1Q4USF7_9ACTN/1-93                ...........................MDE.EPLADFAERRDAR---....IGRLRAVPVVDGRApRAAHVSPAEPRVVERWNGHV..WEMHAVVPDLAAAKALLYPGPRT......PP-.PAE-..........--GP.PLGKGPGRHRKP..........
A0A6G2VTD1_9ACTN/1-100               .........................md-AD.EPLDEWAKRREERKRP....IGELKAVILGHEH-.AAAHLHPRAPRVILRWDGYQ..WSPYRMADGYAAAQRVLHGTDDG......QAA.VLPT.........gPSGQ.PMAPGTGRHRKP..........
A0A7U3UWJ2_9ACTN/20-96               ......vdagdplaayekrrrppldvw---.----------------....---RRHRPLYGG--.-GGHLQPDTPRALEEWNGFS..YEPAGTAANLAAAQRWVNEQTSA......DE-.----..........----.------------saa.......
A0A6H9UPX1_9ACTN/21-95               dadnpfaaydkrrrppmdiyrrhrpah---.----------------....-------------G.GAGHLRPDEPRVLEEWSGFA..YEPAGTAPGLAAAQEWVNE----......---.----..........----.------------lqvgddpa..
A0A2W2LXR3_9ACTN/21-92               .........................dp--D.APLAAYAKRRRPPMD-....-VHRRHRPVHGG--.-AGHLRPDEPRVLEEWDGFA..YQVVGTAPDLVGAKEWVNREPD-......---.----..........----.------------ap........
A0A7Y5XDP3_9ACTN/1-87                ...........................MED.EPLDEWAARRSRRLRP....AGALRAVIVGRPVA.TAAHLFPDEPRAIEEWDGYQ..WLPVTLLGDYASACRYLDPNATA......VAH.EAAE..........----.------------qaaa......
A0A2L0NEE5_9ACTN/2-97                ..........................v-DD.EPLESWMARRDASRRP....VGALKAVRL-DGTE.GAAHVRPEEPRLVMRWDGVQ..WLPETVVADYAAAQRLLHGVDGD......GVV.R-PV..........-PAP.KLGRGTGRHRKP..........
A0A0G3UZG7_9ACTN/1-96                ..........................m--D.DPLDRWAARRAKRLRP....VGERKAVTLVPGA-.QGAHVHPNAPRLILEWDGYQ..WTTLATVADLAAARRFLNPQTAD......DAR.PTP-..........PARS.PMAAGTGRHRKP..........
A0A2M9JEU1_9ACTN/1-98                .........................md-SE.EPLEEWARKREERRER...aRGRLRAVPLTEGPH.RGAHVDPGAPRAIQEFNGTE..WVTVSIADSLEAAKAILYPPGPV......DEQ.PFPG..........---P.SLGKGRGRHRRT..........
A0A345T391_9ACTN/4-101               ..........................p-DD.EPVSDWYAARAGGTRP....PGTRDALVLASDV-.RRGHLFQDTPRLVVEWDGQE..WQPLGVADTYADAYPVIVRRGSG......FAA.PQDD..........TPVP.LLRKGSGRHRKP..........
A0A1H7NPB4_STRJI/11-86               ......................pggll---.----------------....-GALRADPLEPGL-.-ARMEAPDRPRLIQQLTADG..WRPCAVAPDLRTAYDSLYRPPPP......GTG.RHRA..........----.------------pdlqspprtp
A0A101NL57_9ACTN/1-95                ...........................MDD.EPLRDWAERRDAK---....IGRLRAVPVVSGDGpRASHLNPDAPRAIERWNGHM..WEPYGFAATLAEAKAILYPEASE......PPP.AS--..........PVPK.PLGSGTGKHRKP..........
A0A2Z5K466_9ACTN/117-206             .....................emarrd---.-------RRRAAERQT....TGTRRAVSLADGA-.RASHVAPDAPRALMEWDGQT..WVTVGVAPNADAAREFLGHVPAP......APE.SGPR..........PS--.------------eappyvwrtp
K4R937_STRDJ/21-100                  .......dpanplapyekrrrppmdvw---.----------------....---RRHRPLHRG--.-GGHLHPEQPRALEEWNGFS..YEPAGTAPNLAQAQRWANEQTTG......QHD.----..........----.------------esppat....
#=GC seq_cons                        ............................p-.EPLppWApRRct+.......hGphRAlPLssGs..puuHlpP-sPRslpcWsGap..WpPhGsAssLAsApphLhs.sts.......s.......................t.utG+HR+...........
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