#=GF ID   DUF6092
#=GF AC   PF19585.3
#=GF DE   Family of unknown function (DUF6092)
#=GF AU   Williams LS;0000-0001-5551-8526
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Fragoso S;0000-0001-7018-3891
#=GF SE   Manual
#=GF GA   28.70 28.70;
#=GF TC   28.70 42.30;
#=GF NC   28.30 25.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR046074;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents a member of a biosynthetic gene cluster
#=GF CC   (BGC). This BGC (BGC0001986) is described by MIBiG as an example
#=GF CC   of the following biosynthetic class, other (unspecified). This
#=GF CC   family  includes a member from the purincyclamide biosynthetic
#=GF CC   gene cluster from Streptomyces chrestomyceticus and appears to
#=GF CC   be predominantly found in bacteria.
#=GF SQ   56
#=GS A0A160NXE2_STRLU/13-97   AC A0A160NXE2.1
#=GS A0A2K2TQM8_9CLOT/4-89    AC A0A2K2TQM8.1
#=GS A0A1V0AK25_9ACTN/3-87    AC A0A1V0AK25.1
#=GS A0A0L8QUJ0_9ACTN/16-79   AC A0A0L8QUJ0.1
#=GS A0A0K9XL38_9ACTN/14-99   AC A0A0K9XL38.1
#=GS A0A2H5UY32_9ARCH/8-94    AC A0A2H5UY32.1
#=GS A0A292YS60_9BACL/15-100  AC A0A292YS60.1
#=GS A0A133UYV5_9EURY/6-71    AC A0A133UYV5.1
#=GS A0A2Y9BGM8_9FIRM/5-90    AC A0A2Y9BGM8.1
#=GS A0A848DEB9_9PSEU/10-96   AC A0A848DEB9.1
#=GS A0A329R0E6_9ACTN/7-94    AC A0A329R0E6.1
#=GS A0A7V8NBP7_9ACTN/14-98   AC A0A7V8NBP7.1
#=GS A0A1Q4UXD0_9ACTN/13-97   AC A0A1Q4UXD0.1
#=GS A0A0S7BUG8_9CHLR/13-97   AC A0A0S7BUG8.1
#=GS A0A429S3K9_9ACTN/10-96   AC A0A429S3K9.1
#=GS A0A174KET5_9FIRM/4-88    AC A0A174KET5.1
#=GS A0A0A8EP93_9ACTN/8-93    AC A0A0A8EP93.1
#=GS A0A1Y4SCF8_9FIRM/4-89    AC A0A1Y4SCF8.1
#=GS A0A0B7ML06_9FIRM/8-92    AC A0A0B7ML06.1
#=GS B2HLT0_MYCMM/15-99       AC B2HLT0.1
#=GS A0A7Y7B1U2_STRMO/15-100  AC A0A7Y7B1U2.1
#=GS A0A0J1J249_9FIRM/8-94    AC A0A0J1J249.1
#=GS A0A3A4A687_9ACTN/1-85    AC A0A3A4A687.1
#=GS D7B1W7_NOCDD/13-97       AC D7B1W7.1
#=GS A0A059WGD3_STRA9/14-99   AC A0A059WGD3.1
#=GS A0A0Q3QKS7_9BACI/22-107  AC A0A0Q3QKS7.1
#=GS A0A1I7LHV0_9BACL/19-56   AC A0A1I7LHV0.1
#=GS S3BSA3_9ACTN/13-97       AC S3BSA3.1
#=GS A0A1S2M3Y1_9BACI/4-68    AC A0A1S2M3Y1.1
#=GS N0BGA7_9EURY/8-93        AC N0BGA7.1
#=GS A0A2U1FFT3_9PSEU/10-95   AC A0A2U1FFT3.1
#=GS A0A4Y3QT91_STRCI/14-98   AC A0A4Y3QT91.1
#=GS E4RP88_HALHG/7-98        AC E4RP88.1
#=GS A0A0J1INH7_NIACI/14-99   AC A0A0J1INH7.1
#=GS C5ER21_9FIRM/4-89        AC C5ER21.1
#=GS A0A5D8QGB3_9THEO/6-91    AC A0A5D8QGB3.1
#=GS A0A4Q9HRR4_STRKA/15-100  AC A0A4Q9HRR4.1
#=GS A0A1V3ZZV8_9ACTN/16-100  AC A0A1V3ZZV8.1
#=GS A0A1I2RBS9_9FIRM/8-93    AC A0A1I2RBS9.1
#=GS J7L6T9_NOCAA/3-88        AC J7L6T9.1
#=GS A0A1I1S8J6_9ACTN/23-108  AC A0A1I1S8J6.1
#=GS X8F0F9_MYCUL/207-291     AC X8F0F9.1
#=GS A0A1R1ETS9_9BACL/12-97   AC A0A1R1ETS9.1
#=GS K4LGD0_THEPS/9-93        AC K4LGD0.1
#=GS A0A369LG44_9ACTN/4-90    AC A0A369LG44.1
#=GS A0A372LSY3_9BACI/15-100  AC A0A372LSY3.1
#=GS A0A7K1FP62_9ACTN/9-93    AC A0A7K1FP62.1
#=GS W4RPE1_9BACI/15-99       AC W4RPE1.1
#=GS A0A1H3BPT8_9FIRM/11-93   AC A0A1H3BPT8.1
#=GS F4CUQ5_PSEUX/13-99       AC F4CUQ5.1
#=GS A0A410Q647_9FIRM/4-89    AC A0A410Q647.1
#=GS A0A5N8YTD7_9CHLR/10-95   AC A0A5N8YTD7.1
#=GS A0A6I4PTP6_9ACTN/12-95   AC A0A6I4PTP6.1
#=GS A0A7W8AEG0_9ACTN/10-93   AC A0A7W8AEG0.1
#=GS A0A1Q9SQL3_9PSEU/12-98   AC A0A1Q9SQL3.1
#=GS A0A1G8XXT2_9CLOT/9-91    AC A0A1G8XXT2.1
A0A160NXE2_STRLU/13-97              ...EELILLAAYLLSCGRGLLDEPQVYGTFRCIDAARRVLVLLKD.RG....LDNSELLALHSQLEDFMCGPM..IQ-..RDVTGFLDEVCLRLTL--ql.
A0A2K2TQM8_9CLOT/4-89               ...NDYFELLVYMITSAAGLEGEPRIYGPLRMIEASQRLCRLILS.ED....PENQNLKELIELIENGKGKTM..SDE..KAFYQMLQDAAAKLVDCI...
A0A1V0AK25_9ACTN/3-87               ...EELLLLAAYLLSSGRGLLDEPAAYGPLRCLDAARRVLALAIR.AG....AGNEDVAALRAELDDVMCGAM..TE-..RDLDHFLDHLCERLGA--ll.
A0A0L8QUJ0_9ACTN/16-79              ...DDIVLLAAYLLSSGHGLLDEPADYGPARCADGARRALELLDA.YG....GADPALLGVRRRLEDAMCG--..---..------------------s..
A0A0K9XL38_9ACTN/14-99              ...EDIALLAAYLLSSGRGLLNEPSDYGAFRCADAARRTLEILER.AG....GSSPGLTEVRERLDGVMFAPM..GGD..TDIAAVLDELCLKMADSL...
A0A2H5UY32_9ARCH/8-94               ..r-EIFDYILFLLTAARGCVDEPHMYGPLRLVDAASRIIGTYQRvKG....VDDEFLNRLKQLIDEKKYIVM..ESE..DEFTRFIDELIAQSVDEM...
A0A292YS60_9BACL/15-100             ...NRLLDYVSYVLTSARGLYKEPHSYGPMRMVDSLEKALFLLRD.MG....IKDDAIEESVAVIRENRWRVT..SDP..EAFAQALDDAILRLVKV-t..
A0A133UYV5_9EURY/6-71               .dp--FYDLICYIATSARGCVEEPKIYGSFRLIETMERVINILEE.EG....YADDFYLNLRDKINDERNR--..---..------------------ktr
A0A2Y9BGM8_9FIRM/5-90               ...EAYMELLIYMITSAAGLENEPHIYGPLRMIEASQRLCGLMQE.ED....PDNEDLKELIRIIENGKQKST..SDE..EAFYQMLQDAAAKLVDLL...
A0A848DEB9_9PSEU/10-96              ..d-QALELLAYLVTAARTQVDEAAEYGPMRLLTAAGRLAAMIRP.RA....-SEGLQDVLAGPLGSVPPTAV..PRTgrEAYVARLDGICRELAEHL...
A0A329R0E6_9ACTN/7-94               ..q-AIFGIITHLVTSAPTSLQETPSLAAFRMVDAAHRLMELVNE.NDt..fQQDEFLQSARAEYMANFNLVM..TDP..DAFDAWLASYVQSFTRE-a..
A0A7V8NBP7_9ACTN/14-98              ...EDLVLLAGHLLSCASGLVEEPAYYGIFRCMDSARRTLEVLAE.HA....ELDPRLAELRDELERTVSGAQ..NG-..QSVEEFLDDVCLRMARI-v..
A0A1Q4UXD0_9ACTN/13-97              ...EELLLLTAYLLSSGRGLLEEPQQYGPFRCIDAARRVLVLLRD.RG....VTNSELQELHGRLEDFMCGPM..AP-..RDLTAFLDEVCGKLTL--ll.
A0A0S7BUG8_9CHLR/13-97              ...NELFMLVSYVITSARGLYDEPDNYGIFRLIDSAGRLLAIMES.AG....MSDDFIASLREQIDEERESSM..DD-..DAQKRHLDAMVLKIAREL...
A0A429S3K9_9ACTN/10-96              ...DDAVELLAYLVSAARTQVDEAAEYAPLRLLTAAGRLADMIAP.AA....-SDGLRPFLEDIRQGFGETTLaaGDP..DGYVDRLDGLCRTVALH-l..
A0A174KET5_9FIRM/4-88               .pe---FELLVYLITSAKALPEEPACYGSIRLTEAASRLCKIICE.KY....PENDAYRALLGCIDADKGKAL..TEP..EGFAKMLEKASEMLVDCL...
A0A0A8EP93_9ACTN/8-93               ...EEIALLAVYLLSSGRGLLEEPADYGIYRCTDGARRALQLLDE.HG....GSTARLTAVRERLDEVMFAPM..GED..RDMGAILDDLCRQMADAL...
A0A1Y4SCF8_9FIRM/4-89               ...EDYFELLVYMITSAAGLKGEPKIYGPLRMIEASERLCSLMLK.ED....PDNPDLKELREIIETGKQKTT..SDE..EGFYQMLQDAAAKLVDM-v..
A0A0B7ML06_9FIRM/8-92               ..t-KFYELFCFILTSARGCVDEPPIYGPLRLLDTYSRLIDALDE.-G....SVDPFWQELKEQIDSYKNDAM..YDA..EGFVKAIDQTLAAVAQH-i..
B2HLT0_MYCMM/15-99                  ...DELVSIVAYLLGSAALTDQEAPAITALHFVGAGMRILEIVAQ.ET....-DDDFAQAKMKTIEQRIQQVL..GDP..AALSEYLHCIAKEFAKEV...
A0A7Y7B1U2_STRMO/15-100             ...EEIALLAAYLLSSGRGLLEEPADYGAFRCADAARRTLEILEK.AG....ASTPALTAVRERLDGVMFSPM..GGD..IDLAGILDELCLQTATA-l..
A0A0J1J249_9FIRM/8-94               ...DRCFELLVYLVSSAAGLKKEPHIYGSLRLIEASRQLGQILAD.AD...dTKSAAFTELIDTIENSKNKCM..TDQ..DAFYQMLEEASLKLVDCC...
A0A3A4A687_9ACTN/1-85               ..m-RIAHVAAYLLASGRTMLSEPMEYGPFRLLDGARRALALLEG.DD....ETYARFASIHDRIQEVFQTVR..LD-..IDLPTLLDELCLEMAA--gm.
D7B1W7_NOCDD/13-97                  ...EELLLLAAYLLSSGRGLLDEPRQYGTFRCLDAARRVLALAAG.TG....PHHPELDALRGRMDDVMCGPM..GD-..HELDTLLDQMCERLATVL...
A0A059WGD3_STRA9/14-99              ...EDIALLAAFLLSSGRGLLDEPADYGIYRCTDGARRVLQLLDE.HG....GSTARLTAVRERLDEVMFAPM..GED..RDMGEILDDLCRQMAG--al.
A0A0Q3QKS7_9BACI/22-107             ...EDLLDYVAYTLTSAKGLYREPHSYGPMRMIDSMEKALHLLKE.AG....IQDEALEEGLAAVRNARWKAM..TES..EEFGKAMDESILNLVDI-t..
A0A1I7LHV0_9BACL/19-56              ..e-TLRDYIGYVLTSARGLYGEPLSYGPMRMFDALEKSL-----.--....---------------------..---..------------------v..
S3BSA3_9ACTN/13-97                  ...EELVLLAAYLLSCGRGLLEEPQAYGPLRCLDAGRRVLTLVEQ.AG....LHDERLSAVRARLDDCMCGPM..EY-..RDLPGFLDEVCGSLITA-l..
A0A1S2M3Y1_9BACI/4-68               nvm------------------------GQLRMIDSLEKSLVLLKN.AG....VDIQTVDNAMATIRKDRWRAT..SDP..EAFANAIDRAIDELVNV-t..
N0BGA7_9EURY/8-93                   ...KEFFELLCYVLTSARGLMDEPKMYGPFRLVDTASRIISILEK.HG....IADDFLAEERKKIDEGKYSVM..ESE..EKFKEFLDRIIQDFAEEL...
A0A2U1FFT3_9PSEU/10-95              ...DDALELLAYLVTAARTQVDEAAEYGPMRLLTAAHRLAEAMGP.RS....-SPETAAALGGPLAAMPTLAV..PRD.rTEYVEQLDAACRSLAAHL...
A0A4Y3QT91_STRCI/14-98              ...EDLVLLTAYLLSTGHGLLHEPAAYAPARAVDAARRTLGLLAE.HD....GPDRRLDEVRARIDEFFTDPH..DG-..EPLAELLDELCVRMAEV-v..
E4RP88_HALHG/7-98                   ..k-EVLKLISHMTTSARGLIDEPKSYGPFRLIDSTIKLYQTLEK.ADvikeKNETDLDEIISELDEIKRECL..AEDcqEDCAENLDSIINKLVVE-l..
A0A0J1INH7_NIACI/14-99              elv---RDYSGYILTSAKGLYREPAHYGPLRMVGALERTLVLLTE.LG....IEDKEMEEVLSFIRKEGWRAL..SDP..LGYEKALDKSIDQLVEL-t..
C5ER21_9FIRM/4-89                   ...DKYFELLVYMITSAAGLGGEPRIYGPLRMIEASERLCMLMLE.ED....PDNQDLKELAEIIEAGKHKTT..SDE..DGFYQMLQDAAAKLVDLL...
A0A5D8QGB3_9THEO/6-91               .vd--YRDVLAFMVTSAVGLFHEPKLYGPLRLLESASMLIEYAKG.ND....IQDETLDEINSRIKKCTKLVM..TNE..EKFEEGVNEILKLIIE--al.
A0A4Q9HRR4_STRKA/15-100             ...EEIALLAAYLLSSGRGLLDEPADYGAYRCADAARRTLGILEQ.AG....ASTPQLSGIRHRLDEIMFSPM..GGD..LHLPEILDDLCLQLAG--al.
A0A1V3ZZV8_9ACTN/16-100             ...EQIALLAAFLLSSGRGLLEEPTAYGPARCADGARRTLELLER.YG....PCDARLVALRTRLEEAMSGPM..GE-..VDLVALLDDACDRMAEVL...
A0A1I2RBS9_9FIRM/8-93               ...EAYYDLLGYVVSSAKELVVDPKLYGPLRLVDTASRLIGILME.EG....RSDDFLVSLKDYIDENKHLVM..TDE..AEFIAFLNELVVKVAEF-t..
J7L6T9_NOCAA/3-88                   ...EELLLLAAYLLSSGRGLLQEPPSYGPLRCLDAARRVLALRDG.LG...gQESPALADLRASMDDVMCGAM..TD-..RELDVLLDDLCDRLAAV-v..
A0A1I1S8J6_9ACTN/23-108             .eg--LTLLAAFLLSSARGLLNEPPGYGVARCADGARRTLELLDL.CG...gGPDPRLVRVRERLEETMCGPM..SA-..ADFPALLDRALDEVVSV-i..
X8F0F9_MYCUL/207-291                ...DELVSIVAYLLGSAALTDQEAPAITALHFVGAGMRILEIVAQ.ET....-DDDFAQANLKTIEQRIQQVL..GDP..AALSEYLHCIAKEFAKEV...
A0A1R1ETS9_9BACL/12-97              ...ERMLDFAAYVLTSARALYREPHSYGPMRLADTLEKGLELLQA.AG....IRDETVEQAMAAVRESRPVAM..TDP..EGFAEALDRAIAVLVQA-t..
K4LGD0_THEPS/9-93                   ...NKLLDLLCFMVTSARGCLDEPPGYGPLRLLEAYAMLIDALNE.-G....NIPAVFLEERKNIEGYLMLCM..YDE..KSFQEELDRTVARIARA-l..
A0A369LG44_9ACTN/4-90               ..n-DAMELLVYMVTSAAGLQGEPEAYGPLRLIEASKRLALMLAE.ED...aDRAAALQELAELIDARKNDCM..TDE..DSFYAMLNDAAAKLVECV...
A0A372LSY3_9BACI/15-100             ..e-HLRDYVAYALTSAKGLYREPQSYGAMRMFDAMERALRLLQE.VG....VKDEALEEALTTVRKQRWQAM..TNP..DAFGKAIDDSILNLVDI-t..
A0A7K1FP62_9ACTN/9-93               ...QELFEVIVYLVSSSVTSMTETPELATFRMIDAAERLMAISTS.RL....-PDDFLTAARADWEAHKMLVV..SDQ..PEYLRWLDGYARSFVRK-t..
W4RPE1_9BACI/15-99                  ...EHLLDYVAYTLTSAKGLYREPQSYGAMRMVDAMERALRLLKE.VG....IEDEVLEDALSAVRKDRWRAM..TDK..EGFGKAIDDSILNLVN--i..
A0A1H3BPT8_9FIRM/11-93              ...DELDKAVCYILTSAKSYVDEPRSYVPMRLLESASIILDILS-.--....IYDNKYLWLNEEINRIKLLPL..ESE..AEYLREIDIILTRLIES-y..
F4CUQ5_PSEUX/13-99                  ..d-DAIEVLAYLVTAARTQVDEAAEYGPLRLLTAARRLAGLLAP.RA....-SEPTATFVRDHVEPMPELAV..PRQgrDEYVARLDGLCAELGS--ll.
A0A410Q647_9FIRM/4-89               ...NESFELLAYLVAGAAGLEGEPRIYGPLRMIEAAERLCKLMLA.DD....PENSSLKELVEIIENGKRKTM..SDE..AGFYQMLRDAAAKLVDCV...
A0A5N8YTD7_9CHLR/10-95              ..s-EAIELLAFLITAARTQIDEPPDYAPMRMLTAAGRLREFILD.RV....-SPEGHQFLKEFLNPAPKSFR..QAG.lEQYSASLDELCRKIARHL...
A0A6I4PTP6_9ACTN/12-95              ..t-ELARLAAYLLASSRSLLTEPASYGPIRLIDAARRTLALLEP.DG....AANPHYNTVKTRIEDSHRSKT..PI-..-DLPTLLDELCLQMAH--gl.
A0A7W8AEG0_9ACTN/10-93              .ra--LYETVTVLVCSAPLALDETRLLSAFRMLDAADRLMGIMAD.HD....--DDFLRRARADFADHRMLAM..TDQ..AAFTDWMSRYVAGFAA--qa.
A0A1Q9SQL3_9PSEU/12-98              ..d-TALELLAYLVTAARTQVDEAAEYGPLRLLTAARRLGAAIAP.RA....-SAGTAAFAAGPLDAVPELAV..PREgrEQYVARLDDLCRALAAHL...
A0A1G8XXT2_9CLOT/9-91               ...EELEEIMFFLITSARGCIDEPASYGPLRLLEAASRLTDVV--.-G....KHNDSYIKLKDEINNSMDIAL..IDE..EKFQEQLDDIILHLAKEV...
#=GC seq_cons                       ...pclhcLhuYLloSA+GLlcEPttYGPhRhlDAAcRlltllpp.tu.....ssstlpplpppl-pshptsh..sc...cshsphLDchstplsp.....
//