#=GF ID DUF61
#=GF AC PF01886.20
#=GF DE Protein of unknown function DUF61
#=GF AU Enright A;0000-0002-6090-3100
#=GF AU Ouzounis C;0000-0002-0086-8657
#=GF AU Bateman A;0000-0002-6982-4660
#=GF AU Cerutti L;
#=GF SE Enright A
#=GF GA 27.00 27.00;
#=GF TC 39.20 39.00;
#=GF NC 22.50 21.20;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Family
#=GF WK Domain_of_unknown_function
#=GF RN [1]
#=GF RM 29526782
#=GF RT Solution structure of an archaeal DUF61 family protein SSO0941
#=GF RT encoded by a gene in the operon of box C/D RNA protein
#=GF RT complexes.
#=GF RA Zhou T, Yao X, Wang J, Feng Y;
#=GF RL J Struct Biol. 2018;203:179-184.
#=GF DR INTERPRO; IPR002746;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This Domain of unknown function 61 (DUF61) family of proteins
#=GF CC are widely distributed in archaea. In crenarchaea, the genes of
#=GF CC DUF61 proteins are in an operon containing two genes of box C/D
#=GF CC RNA protein complexes. The NMR structure of a DUF61 family
#=GF CC member from the hyperthermophilic archaeon Sulfolobus
#=GF CC solfataricus revealed a rigid core structure and flexible N- and
#=GF CC C-terminal regions, including a negatively-charged independent
#=GF CC C-terminal helix. The core structure consists of N- and
#=GF CC C-terminal subdomains, in which the C-terminal subdomain shows
#=GF CC significant structural similarity with several nucleic acid
#=GF CC binding proteins [1].
#=GF SQ 101
#=GS F0LJL0_THEBM/5-132 AC F0LJL0.1
#=GS W9DWT1_METTI/14-142 AC W9DWT1.1
#=GS A0A133UMV7_9EURY/4-129 AC A0A133UMV7.1
#=GS A0A2R4ZUF4_9CREN/13-139 AC A0A2R4ZUF4.1
#=GS A0A133V6U9_9EURY/4-130 AC A0A133V6U9.1
#=GS A0A133UE53_9EURY/4-131 AC A0A133UE53.1
#=GS A0A4E0Q553_9EURY/13-141 AC A0A4E0Q553.1
#=GS A0A2H5V114_9ARCH/13-139 AC A0A2H5V114.1
#=GS C6A5B8_THESM/5-132 AC C6A5B8.1
#=GS A0A498GYU3_9EURY/14-142 AC A0A498GYU3.1
#=GS D3RX98_FERPA/4-130 AC D3RX98.1
#=GS A0A133URF7_9EURY/1-61 AC A0A133URF7.1
#=GS A0A328PDN7_9EURY/5-132 AC A0A328PDN7.1
#=GS E3GZJ7_METFV/8-137 AC E3GZJ7.1
#=GS Y1676_METKA/8-132 AC Q8TUS7.1
#=GS A0A133VN51_9EURY/4-131 AC A0A133VN51.1
#=GS W7KUX3_9CREN/4-123 AC W7KUX3.1
#=GS Y1224_METJA/12-133 AC Q58621.1
#=GS A0A510E3G7_9CREN/3-121 AC A0A510E3G7.1
#=GS A0A0U3E2Z1_9CREN/7-127 AC A0A0U3E2Z1.1
#=GS A0A2R6T5Q6_9ARCH/14-141 AC A0A2R6T5Q6.1
#=GS F0T972_METLA/9-132 AC F0T972.1
#=GS A0A133V9K4_9EURY/9-135 AC A0A133V9K4.1
#=GS B8D5D5_DESA1/7-131 AC B8D5D5.1
#=GS A0A0F7IFZ3_9EURY/7-133 AC A0A0F7IFZ3.1
#=GS M9SFT0_METAX/9-135 AC M9SFT0.1
#=GS A2BIV4_HYPBU/23-141 AC A2BIV4.1
#=GS G0EHE1_PYRF1/22-146 AC G0EHE1.1
#=GS Q97ZH2_SACS2/3-123 AC Q97ZH2.1
#=GS A6UT39_META3/3-126 AC A6UT39.1
#=GS A0A062V006_9EURY/6-139 AC A0A062V006.1
#=GS A0A0A7LA82_9ARCH/2-126 AC A0A0A7LA82.1
#=GS D7DSC2_METV3/22-144 AC D7DSC2.1
#=GS A0A1Q6DW71_9EURY/15-142 AC A0A1Q6DW71.1
#=GS A0A133U930_9EURY/4-129 AC A0A133U930.1
#=GS Y460_ARCFU/3-129 AC O29789.1
#=GS F4B4P2_ACIHW/3-124 AC F4B4P2.1
#=GS E6N848_CALS0/5-133 AC E6N848.1
#=GS A0A1D3L4I6_9EURY/8-131 AC A0A1D3L4I6.1
#=GS F4BY96_METSG/12-138 AC F4BY96.1
#=GS M4YJW0_THEXX/1-121 AC M4YJW0.1
#=GS F2KQ23_ARCVS/7-133 AC F2KQ23.1
#=GS A0A1F2PA14_9EURY/4-130 AC A0A1F2PA14.1
#=GS L0AAQ5_CALLD/22-146 AC L0AAQ5.1
#=GS A0A133VNF3_9EURY/3-130 AC A0A133VNF3.1
#=GS A0A1Y3GBA0_9EURY/20-147 AC A0A1Y3GBA0.1
#=GS Q971W1_SULTO/3-122 AC Q971W1.1
#=GS D5TZR8_THEAM/9-133 AC D5TZR8.1
#=GS D5E841_METMS/14-141 AC D5E841.1
#=GS L0KYI5_METHD/14-142 AC L0KYI5.1
#=GS A0A8J8B4F8_9EURY/14-143 AC A0A8J8B4F8.1
#=GS E0SNN3_IGNAA/1-123 AC E0SNN3.1
#=GS A0A2H5UXG7_9ARCH/5-133 AC A0A2H5UXG7.1
#=GS A0A1D2W911_9EURY/8-131 AC A0A1D2W911.1
#=GS D3TAM4_ACIB4/4-124 AC D3TAM4.1
#=GS U6EEZ1_9EURY/9-132 AC U6EEZ1.1
#=GS I0A2K0_FERFK/12-135 AC I0A2K0.1
#=GS Y949_METTH/7-130 AC O27030.1
#=GS A0A650CNN8_9CREN/3-122 AC A0A650CNN8.1
#=GS G7WQ66_METH6/6-132 AC G7WQ66.1
#=GS A0A133V8E2_9EURY/9-135 AC A0A133V8E2.1
#=GS A0A348B3A0_9CREN/3-122 AC A0A348B3A0.1
#=GS A0A1F2P543_9EURY/4-130 AC A0A1F2P543.1
#=GS A0A0X8XYL2_9EURY/14-142 AC A0A0X8XYL2.1
#=GS A0A0Q4BAD3_9ARCH/1-118 AC A0A0Q4BAD3.1
#=GS A8ACB9_IGNH4/8-128 AC A8ACB9.1
#=GS A0A031LME0_9CREN/3-121 AC A0A031LME0.1
#=GS A0A133VCG7_9EURY/4-130 AC A0A133VCG7.1
#=GS Q5JJ68_THEKO/5-132 AC Q5JJ68.1
#=GS A0A2T9WZV6_9CREN/16-139 AC A0A2T9WZV6.1
#=GS Y452_PYRFU/5-132 AC Q8U3L4.1
#=GS D7EA49_METEZ/15-143 AC D7EA49.1
#=GS A0A2T9WTB8_9CREN/3-123 AC A0A2T9WTB8.1
#=GS A0A8J7UQ99_9EURY/14-141 AC A0A8J7UQ99.1
#=GS A0A2H5V6T4_9ARCH/5-133 AC A0A2H5V6T4.1
#=GS H2C8G3_9CREN/3-121 AC H2C8G3.1
#=GS F6BCS9_METIK/1-124 AC F6BCS9.1
#=GS A0A2T9WY16_9CREN/3-122 AC A0A2T9WY16.1
#=GS A0A110A343_THEX5/9-135 AC A0A110A343.1
#=GS N0BHL7_9EURY/4-130 AC N0BHL7.1
#=GS Q4J959_SULAC/3-124 AC Q4J959.1
#=GS A3DNR3_STAMF/10-134 AC A3DNR3.1
#=GS D2RGG3_ARCPA/6-132 AC D2RGG3.1
#=GS A0A133U4P2_9EURY/4-131 AC A0A133U4P2.1
#=GS G7WLP2_METH6/5-134 AC G7WLP2.1
#=GS A0A483CRW3_9EURY/14-141 AC A0A483CRW3.1
#=GS A0A656YWR5_9EURY/4-129 AC A0A656YWR5.1
#=GS A0A2U9IGE9_9CREN/3-122 AC A0A2U9IGE9.1
#=GS E6N347_CALS0/5-133 AC E6N347.1
#=GS A0A6B9TB03_9ARCH/3-129 AC A0A6B9TB03.1
#=GS F7XNU0_METZD/14-142 AC F7XNU0.1
#=GS A0B7E5_METTP/7-135 AC A0B7E5.1
#=GS A0A133VBB2_9EURY/4-130 AC A0A133VBB2.1
#=GS D9Q332_ACIS3/12-137 AC D9Q332.1
#=GS Q6LYE3_METMP/2-124 AC Q6LYE3.1
#=GS A0A656YWD3_9EURY/1-103 AC A0A656YWD3.1
#=GS A4YHH7_METS5/3-121 AC A4YHH7.1
#=GS Q9Y9U4_AERPE/14-138 AC Q9Y9U4.1
#=GS A0A2V3JEA6_9EURY/7-140 AC A0A2V3JEA6.1
#=GS A0A0V8RUX9_PYROC/20-142 AC A0A0V8RUX9.1
#=GS I7JAS8_METBM/14-142 AC I7JAS8.1
F0LJL0_THEBM/5-132 ...............d-EIINKEIARINLHLPRARKSLAKLLNEDVPKVQLRDGSFHYFKKEELEYLQSLLDVEEL....EKLHLPIVLEIT.TA-.WHGYFR.VRGKVE..VKVIEKVLGTYd......iLEEKVEVTLPRYLLPKIRRTLPTTTTYAF....
W9DWT1_METTI/14-142 ................MRWMRIEVGKLNDGLVSERKSLAQLLTEERPVSRTKSGEEHVFDKDILEELGSKLPTDLH....RKLKIPIIFFSD.NRV.PDSCYI.NDPVALeaLQILGEMSKMR........RMQQGKLWIGKSIAYTIMKKYLSVVQIA-m...
A0A133UMV7_9EURY/4-129 ...............d-EIIKKQIQNLNRHLPKGRISLEKLLEQDKPRVENRDGDTHRFKRRELEYLADLLPPEKH....SKLRLPIIVRIS.PEL.GRGASK.ISGKIE..REVIEKILEKE........-GDEDELVIYRPEIRKIRRKLPTTTQYAF....
A0A2R4ZUF4_9CREN/13-139 .............yyk-----ELVKSLANMSPKDKKRLSEAARAEITYVDLVGGDRHAVLGSEAKDLASNIPRDLA....DHIRVPMIIAKV.SG-.-TSFYR.LLDCNEktSRMLLELRSRGv.....isSDYADRCILTQADTISLIKKYKTLF----iis.
A0A133V6U9_9EURY/4-130 ................DRFLRKQIQTLNRHLPKRRASLAKLLKEEKPQVTARDKTTHRFKKQELKYLAELLPKDLH....KRLRLPIIIRIS.PQL.GRGAAK.ISGKIE..RTVIEKILEKE........KSEEDELVIYRPEVRIVRKKLPTTTQYAF....
A0A133UE53_9EURY/4-131 ...............k-KFLKKEIRSLNRHLPKGRTSLAELLEQKKPRIETRDGSTHRFKKDELEYLAELLPEEKH....SKLKLPIIIRIS.PQL.GRGAAQ.VSGKIE..QKVFREILDKE.......gRKKDNKLLIYRPEVRKIRQKLPTTTQYAF....
A0A4E0Q553_9EURY/13-141 ...............m-SWMRLEVSKINEGIVTERKSLAQLLIEERPASKTKAGEDHLFDKDTLQFFRENLPGELH....YKLKLPVLFFNS.MNV.PDSCYL.NDESALlaLQVLGDLSKLR........RMQRGKIWVGRSIAYSIMKKYPTAVQIV-m...
A0A2H5V114_9ARCH/13-139 ...............e-AWFSKQIRSFQDIFPARRASIRELLNQSRPYVETRGGGRHYFSRRDLEAAASKLPAELL....DAPIFPIVFTRG.EV-.-EDLYI.VRGAEA..ADAFARLSDLNg.....ldSLPTGEFYTYKSLVLHFLSRYPSL-----giia
C6A5B8_THESM/5-132 ...............d-EIIHREISRLNLHLPKSRKKLGQLLEEEEPKIQLRNGQFHYFKKEELEYLFSLIEENEK....DLLYLPIILEIT.TL-.WHGYFK.VRGRVA..VKVVEKVLGSYd......mLEEKTEVILPRYLLPKIRKKLPTTTTYAF....
A0A498GYU3_9EURY/14-142 ................MRWMRLEIGKLNEGLVAERKTLRRLLEEEAPSSTTKSGQEYLFDAGLIRQLGEQLPPDLH....RRLKLPMLFYFD.MTV.GGSCFL.TEEAAMeaLQHLGEISHLR........RMREGRLWFAKPIAYDLMNRYPTVIQIV-m...
D3RX98_FERPA/4-130 ................ERTLAKLAEAMNKHIPRSRRSLKELLEMKDPTYIAKDGNEYYIEKKELEFIAEHVDEIYW....GRFWIPIILEMT.SIG.SEYVIF.VRDKLH..AEFISKAFGID........RFTKQGLMLYSYEMQKVRKKLRTATQVFF....
A0A133URF7_9EURY/1-61 ...............m------------------------------------------------------------....---RIPIYFRHT.AKE.ERGPYE.VKGDLE..QKVGAEVLNTE........----SKEYYYRPEVREIRGKLRTTTVYMF....
A0A328PDN7_9EURY/5-132 ................ERIIKKQIVILNRHVPRKRKTLKELLGEEKPHVIGGDGSRHRFKTDELKFIASLLSEDEQ....ERLRLPIYIEID.ATI.--SGAR.IKGKLE..VKIVSKIIGREi.....deCDIPDEIHIYNPEIKILRRELPTTTQYIF....
E3GZJ7_METFV/8-137 ...............g-RILKKEILSLNRHVPKRRKTLKELLEEKKPHVIGLNGKRHRFKKNELKLIASILSPEEY....EKIKLPIYLEMG.TS-.-TSGIR.IRGKLE..SRVILYVLGKEke...ideLKNKNEIYIYKPELRIVRQKLPTTTQYIF....
Y1676_METKA/8-132 ................DKYVIKEILRINRHLPRRRKTLEELLREERPHVVNRDGTKHYFDRDELERLADILPRYLH....GRLKLPILIELG.YS-.--GAAV.IRGKAE..VRVVCEVLGEE.......wRFSQDRVELNMLDVRKLRREFPTATQYMF....
A0A133VN51_9EURY/4-131 ...............d-ELLKKQLQNLNLHLPRSRASLAELLKKEKPRIETRDGSSHRFKKNELDLLAEILPKEKH....GQLRLPIIIRIS.PQL.GRGAAK.ISGKVE..QEVLRKILDKK.......eREGSEELLIHRPETRTIRKKLPTTTQYAF....
W7KUX3_9CREN/4-123 ................DKIIDLGFKDIFSSMPAEFVTLDEAVKGKNVIRL-GNGFLHKFDEREVDRASKSIPIYLW....ALVKLPFVILKL.ETP.GD--YV.VNGDEW.sKRAVSLLLGKD........----NSDYLTSGDVERLLMGYKSLIF---it..
Y1224_METJA/12-133 ................EKIIKGIIKDMNPRF--KRKTLRELLSEEKPHVI-INGKRHRIKRRELEFLKEIASED--....--LKIPIVLEVD.SSL.GG-AIK.ISGKEE..VKVISKILGKEi.....diFSEKDVMYIYKPELKIVRKELPTTTQLIF....
A0A510E3G7_9CREN/3-121 ................DKIFDLGFKDIFNSLPKEFVTITDAVKGKNTILL-GNGIPHTMKESEVTALSSKIPVYMW....SMVKIPFLVVKT.TNV.GE--YL.VSGSEW.qKKAISILVGRE........-----TDFLSTVDVEELIRGYKSIIF---is..
A0A0U3E2Z1_9CREN/7-127 ...........iklti-----SDFATINQSVPKEQIPLLRALRGEREVPL-KDGTVHLMDEDDLQRLSNAIPSWLR....WLVKVPIVLSYN.PE-.-TGALS.VMGDQW.qEEAVRNVLGLE........R--DEKLKFYH--LDKLVMELGSLVFVIF....
A0A2R6T5Q6_9ARCH/14-141 ...............k-RILAKQIQNLNKHLPKKKKTLKELLKEEKPSLKTKDNEKILLEKKELKKISEKLPNHFH....NKLKIPIYIEAG.KKF.GKGSYR.IKGKAE..ARLIRRLLDKE.......kDISKKEIFLNRIEVRKIRNQLRTTTKYMF....
F0T972_METLA/9-132 ................DKLVKKQILILNKHLPRKRKFLEELLKEDKPHVIGADGTRHRFKREELERISGILGKSNF....NKLKLPIYIEID.SN-.-ASGSR.IAGKYE..SEVVCKILEID........-NCETEMYIYRADLKKLRSILPTTTQYIF....
A0A133V9K4_9EURY/9-135 ................DRFLKKEIQYLNRHLPRKRSSLADLLKQEKPKIDTKDGKSHRFKRKELQYLSNLLPKNLH....KRLRLPIIITIS.PQF.GRGAAK.ISGEAE..CLVALKILEKE........KKEEGELLIYRPEIRALRKKLPTTTQYAF....
B8D5D5_DESA1/7-131 ................ERFLSEELRLVNKHAPYERKNLCELLKMEIPYIVLRDGSQHVLDPRELRRLRDILADDA-....CSLQLPIVIEYI.PGE.REGIYV.VRDEIG..AKAIASVMNIG........-NPTTPLFLSRAHILELRRILRTTTTIL-l...
A0A0F7IFZ3_9EURY/7-133 ................DRALAKLVESINRHLPQRRVSLKTLLEMDSPAIRARDGEEYDIERDELEFIARYVDEYEW....DRFSIPIILEMR.NLG.SEYVIY.VRDRRH..AEFIEKAFGFD........RYVDDVMLLYVYEMQRIRRRLKTASQVMF....
M9SFT0_METAX/9-135 ...............p-RNIEAMIAGMNSNLPVRRRTLMDYIENGGDTFDTRSGDKASFDRCGIDYLDSICTDQEK....LLLRLPILVSTD.PSS.ENGGWK.IDGMTE..VAVVSRVLGRR........VHAEDRISVYYPDLICLKKLIPGLIFTVF....
A2BIV4_HYPBU/23-141 ..........rffeei--------------LPREYKELPRLLEEDEPSVELISGSRHYFDKRELLELSNSLPWYLR....GFTKLPWIFTYA.RQG.FVGIYKlINSDPW.sGRIIAYLIRGD........-YSKPMLEVREVEFQRLLSRFKTLI----ivt.
G0EHE1_PYRF1/22-146 ..........drvlrd-------ARRILGAWPAEQKPISRLLREEKPLIRLVGGGTHLLDRGELEDMASRIPWFMH....ELVRLPIVIVYR.RIA.GSGVYR.VEGDVW.aARAVSVLLGGG........-YWEEKWELSYEEVSELIKRYKTLFF---vt..
Q97ZH2_SACS2/3-123 ................DKIFEIGLKDIFSSSPAEYVTIKDALDGKLKIRL-NNNFYHEIKKDEVEKLSSRIPLYLW....SLVKIPFIFIKS.SEI.GE--YF.VSGEQW.nKKAISILLGRE........---ISNVILNV-DVEKLLREYTSLIFII-l...
A6UT39_META3/3-126 ................DKTIKGFLHGLNTNF--KRKKLHELLNEDKPFVI-IGGKRHRIKKRELNLIKELNASE--....-NLKIPIPLEVD.ASL.GDGTVI.ISGIEE..VKIISKILNKDi.....nlFEENKIMYIYKPELRILRRELPTTTNYLF....
A0A062V006_9EURY/6-139 ...........disir------FIQILNRSLPAKKKTLKELLLEDKPSIKNRDGSTHLFDRKELEKLAAMVPEQER....GRLRLPLYLEMS.ASM.ERGSIK.ISGRLE..CMIIKKILYGDepskdkyaEDIKDYMIIYYPHLLKIRKELETTTQFMF....
A0A0A7LA82_9ARCH/2-126 ...............d---IERTIRDMNRHVAVSRKTLLEYLESGLDSYDTKDGQKCSVDRKDIELLAANCTEIEK....MRLRIPIFVSTD.TSY.EGGAWK.IEGKAE..VAVVSKLLNKR........VHTDDFLRIYFPDLKDLRKMVPSVINVVF....
D7DSC2_METV3/22-144 ................DKHIYGLIKGLKSSF--TKKTLGELLNEDKPVVM-VNGERHRIKRRELDYLKDIASKD--....--LKIPIVLQVD.SNL.NEGTVK.IEGIDE..VNVISKILSKEi.....nkFDENKLLYIYKPELRIVRQKLPTTTTYLF....
A0A1Q6DW71_9EURY/15-142 ...............k-KLLIKQLRDLNKHLPKGRKTLKELMEVDDPEFEGKDNSIQKVDEEELKKLEKIVPSEFY....DRLKLPIYIEAS.RKF.NRGTYR.VKGKLA..TKVVKSILDKE.......wKVSDEEVFIYRPEVLKLRRELKTTTRYTF....
A0A133U930_9EURY/4-129 ...............d-EIIKKQIQNLNRHLPKGRISLEKLLEQDKPRVENRDGDTHRFKRRELEYLADLLPPEKH....SKLRLPIIVRIS.PEL.GRGASK.ISGKIE..REVIEKILEKE........-GDEDELVIYRPEIRKIRRKLPTTTQYAF....
Y460_ARCFU/3-129 ................EKTLAKMIEAVNKHMPEKTRSLAEMLKEKDPTIRAKDGNEYYIEKRELEFIAQHVDELDW....PRFRIPVILEMN.DIG.GERVIY.VRDKLH..AEFIKRAFGFD........RVLNGILTLYMYELPQIRRKLRTASQVIF....
F4B4P2_ACIHW/3-124 ................DKILELGLKEIFGSSPAEKVTLKDALQGKNRIKL-NNGFYHELNLAEVKDFSSKVPLYLW....SLVYLPIIILKL.PEP.GQ--FS.LEGSEW.dKKAVSLILNKE........--EGDKIILNTAEVEDLLRRYKTLIFI--t...
E6N848_CALS0/5-133 ................DDWLAETMRHVNDALPRRAEKLSTLLEMEKPSVETVGGGLHYFDKKELEELLRKLPREVS....ENLYLPIVFAKN.PEL.GESTYI.VKARGS.eAEAFRILMGLRt......lPRVGNQPYTYKPLVTEFINRYPTLA----vig.
A0A1D3L4I6_9EURY/8-131 ................DRLVKKHILSLNRHIPKQRKTLEELLEEDRPHVVAPNGTRHRFKAEELKRIADIVPESEH....HLLKLPIYLEIE.SV-.-TSGAR.VAGNIE..TKVVCSILNMK........-GCSREIFIYRPDIRVLRAKFPTTTQYIF....
F4BY96_METSG/12-138 ...............k-NILVKTIQTMNQHLPNRRLNLTELLAMEKPGIRGKDNTFFIMDKSELKLISESVPRFLW....SRLRLPMLIEMS.PDF.GSGGAR.IQGEAE..VEMVSKILGKE........KPLNKQIVIYLPDVRELRRKLPTTTQYAF....
M4YJW0_THEXX/1-121 ................------MLAGMNSNIPVDRRSLMDYLENGDLTYRTKSGETVEFGREGIDYLASITNDQEK....LTLRLPVFVATD.VTA.ERSAWK.IEGRTE..VAVISRALNRR........VHSEDRMPVYYPDIAEMKKLIPGLVFTLF....
F2KQ23_ARCVS/7-133 ................ERALARMIEAVNKHLPRQSKSLAELLQEEYPTIRARDGNEYLIERKELEFIAQHVDRDEW....DKFSIPIILEMC.NIS.GNVLVY.VRNKRH..AAFLKKAFGYD........RFVDDVLVIYPYEMRPVRRKLKTASQVMF....
A0A1F2PA14_9EURY/4-130 ................DRIIAKSVQGLNKHLPKARKSLHVLLGEERPAVETKDGEIHRIKRAELEMIADMVAEADH....RKVVLPILIEMS.PDC.GPGASK.IRGKIY..CRIVMELIGRE........WKGEEEILIYRPEVRQLRRLLPTASQYAF....
L0AAQ5_CALLD/22-146 ...............q-KKILDKINETQKLWPKETLNLIEVYNGKTSVLL-ESNEYHEFDKEEIKTVLEIVPQYFW....KFIKLPILLRYN.KDSeGRSWYN.VLGDTW.qKRFVEILITGQ........---YSFDGIEELDVEMFLKILKKFKSLIF....
A0A133VNF3_9EURY/3-130 ...............d-DLIKKEIQNLNKHLPKARATLDKLLEQDKPHVESRSGDAHRFKKKELEYLAELLSKEKH....SKLRLPIIIRIS.PEL.GRGASK.ISGNIE..REVIEKIIEKE.......eTEDKKELIIYRPETRAVRKKLPTTTQYAF....
A0A1Y3GBA0_9EURY/20-147 ...............k-RILMKQIKALNNHLPQRRASLKKLTENPELELKTRKGEKFTVNSDEIERISKIVPKRYW....ETLKIPIYIEIN.RKH.SKGTYK.ISGRYA..TMVVSEILNRG.......iDEDKEQLFIYRPEVIELRRELKTTTEYMF....
Q971W1_SULTO/3-122 ................DKIFEIGLKNFLSFYPQDLVSIREALDGKLNIRL-SDGYSHSLKKEEVEKISHYIPLYLW....SLVRIPFVIIKT.MEP.GE--YI.VNGSEW.eIKALSILLNKD........V----SKGLRTGDIEKLIKEYKSLI----iit.
D5TZR8_THEAM/9-133 ...............t-RYLEGELRLVNKHIPYKRRNLCELLKEPIPYIILRDGSVHVFDMEELERLKQVLGNRA-....CDLSLPIIVEYI.PSD.QEGFYV.VNGALE..VEAVSKVLGCE........-GKEEHLILYRPQIIELRRKLRTTTTIL-i...
D5E841_METMS/14-141 ...............a-RWMKGEMSRINRAIVAQRKTLAQLLEEEVPQSRTRVERRYVFDKQVIRMLGDKLPAELR....DRLKLPILFFFD.FRV.EDSCFL.NDRHALeaLQMLSELGHMY........RMRQGKVWVGKSMAYSIMRKYPTAIQI--t...
L0KYI5_METHD/14-142 ................MRWMRTEMNKLNDGIVSERKSLAQLLLEEKPTARTKGGKDHLFDTATLRNLSEKLPKNLH....DKLKLPILFFFD.NHV.PDSCYL.NDAHALqaLQTLEEISRLR........TMQQGRLWVGRSIAYTIMKKYPTVVQIV-m...
A0A8J8B4F8_9EURY/14-143 ................MKWMALEFGRMNKGIVTSRRTLAELLTEEAPSAATKGGEEHRFDRRVLAALGEKLPQEMH....RRLRLPILFRQD.MTV.ANSVYL.ADEAAVtaLQMLGDLGPLY........RMEKGRLWVSRPIAYAILLKYPTAVQMM-if..
E0SNN3_IGNAA/1-123 ................---MEYELRYANKHLPISRKTLAQLLSEEYPHVVCRDGSIHMFRKSELRELMRYVSSEEA....EKLVLPIIIRVD.TDL.EQLTGF.IDDELS..AKIVARILNIE........-YSKTPLTLYKPQIAILRERFSTAFQIA-m...
A0A2H5UXG7_9ARCH/5-133 ...............d-ELLSETLRRINDSLPKQAVRLERLLKMDTPSVETIGGGIHYFDRDDLEKLVKNLPDHIA....GRLHLPFVFTKR.HDL.GDSVYV.IRTLGV.eHEAFKILMNMAh......lPESNGEYYTYKPVIHEFIRRYPSLA----aig.
A0A1D2W911_9EURY/8-131 ...............d-NILKKQVISLNRHLPRRRKTLEELLREERPHVLGADGTRHRFKNAELKKIASMIDKEDY....KKLKLPIYIEIE.SL-.-TSGAR.IAGDLE..STIICKILNID........-PCKRELFIYRPQIKELRIKFPTTTQYIF....
D3TAM4_ACIB4/4-124 ...............e-NIIQQDILSINREIIKKRVSLQGLLK--DPVIE-EKGKKIKIEKECLDRIAERCNLP-Q....SQIFLPITFFIP.AGS.YDG-YL.LS-EKD..YEVVSSLGYEL........YKRNGRYWIAKYKIRKLVSSCPGVFQS--ii..
U6EEZ1_9EURY/9-132 ................ERLLKKQILALNRHLPQRRKSLKELLEEDKPHIMGVDGTRHRFKKKELEKIASFISQDEW....AKLKLPLYIEIR.SE-.-GSGSR.IKGKLE..CQIVCRILGKE........-DCGEEIYIYRADVKIIRRELPTTSQYIF....
I0A2K0_FERFK/12-135 ...............r-KKVILDLSAIND--PVEEYVRLNEVGNEDVLLKTKSKSFFILKKDDIAKLKENLPSYFH....EMLALPIEINIL.VTP.NNKIYM.LNEDLW.qRRAVRYILNKK........LEYEPKKYITNDELNTLISLMPSVF----kl..
Y949_METTH/7-130 ................DRLMKKEIFNLNRHLPSRRKTLEELLREDRPHVTGADGTRHRFKWAELEDLRGMLTEDEA....RRLRLPIYIEIE.SE-.-TSGAR.IAGDIE..VKVVSEVLERD........-DEGDEIYIYRPEMRVLRARFPTVTQYMF....
A0A650CNN8_9CREN/3-122 ................DKIFDIGIKGTISYYPQEFVTLKQALDGNN-YVKVNGGFKHYFKKEELEKLSKNLPLYLW....DLVKIPFVIVKT.LNP.GE--YV.LNGSEW.eNKAISVLLKKD........----IKSYMTIGDVEKIIKEYKSLVFI--t...
G7WQ66_METH6/6-132 ..............nn--LIVKTVQSMNQHLPGRRKRLTELLQEEKPGVRGKDNTFFIMDKKELKVISEAVPKYLW....DRLRLPILIEMA.PQY.GSGSAR.VQGEAE..GILVRKLLKIE........RGDRKMVIIYMPEIRELRRNLPTTSQYAF....
A0A133V8E2_9EURY/9-135 ................DRFLKKEIQYLNRHLPRKRSSLADLLKQEKPKIDTKDGKSHRFKRKELQYLSNLLPKNLH....KRLRLPIIITIS.PQF.GRGAAK.ISGEAE..CLVALKILEKE........KKEEGELLIYRPEIRALRKKLPTTTQYAF....
A0A348B3A0_9CREN/3-122 ...............e-DILKLSLGAIAESMPAESFTLREAVEG-RRTLRLRDGSTHQLRNEEIESLANRVPKYLW....GLVKLPFVIVKT.NSL.GA--YK.LGGDRW.sVEAINILLNRK........---EGAERLSGIEVEKLLKEFNSLIF---i...
A0A1F2P543_9EURY/4-130 ................DRVIAKAVQSLNRHLPRERKSLYELLREDRPSISSKDGDTYRIKRDELEMIADLIPEDYH....RKLYLPVLIEIC.PEY.GRGAAK.IRGKVQ..CSLVMELLKKE........WRGEEEIIIYRPEVSKIRRVLPTASQYAF....
A0A0X8XYL2_9EURY/14-142 ................MRWMRLEIGRINDGVVAERKRLSHLLREEHPSSVTKGGSEYNFDRGTLLGLEQGLPRDLQ....VRLRLPILFYFD.STV.PDSFFL.ADEAALqaLQHLEEISPLR........RMQGGRLWIAKPIVYAIMNRYPTAMQVM-m...
A0A0Q4BAD3_9ARCH/1-118 ................-------MRDTNSCIPVGRRTLIEHADSNDFSFRTKDGSVCEIGKDEIELLSGVCTEQEK....LTLRLPIFISTD.PE-.-AGAWK.VDGTVE..SEVVSRILGKV........KFRADTVRLHNPDMRELRRLLPNATFMVF....
A8ACB9_IGNH4/8-128 ...............v-RNVIEEFRSINQSVPQER-VLLKAAAEGRRLIKLRDGSEHLMDTDELNEMINLLPSWMK....WVVRVPLLLAYE.PL-.-TGVVK.VLGSEW.dEKAVRRLVGID........--KEEPLRLYH--LERLITRFSSLVFIIF....
A0A031LME0_9CREN/3-121 ................DKIINLGLRDILSGLPSERVSIKDAVEGKLAISL-NNGLVHTMEKKQVEEFSRNVPLYLW....SLVKIPIILAKL.PDP.GE--YS.VSGSEW.dVKALSYVLGRE........-----ISTLYTPDVEELLKKYRTLIFI--t...
A0A133VCG7_9EURY/4-130 ................DRFLRKQIQTLNRHLPKRRASLAKLLKEEKPQVTARDKTTHRFKKQELKYLAELLPKDLH....KRLRLPIIIRIS.PQL.GRGAAK.ISGKIE..RTVIEKILEKE........KSEEDELVIYRPEVRIVRKKLPTTTQYAF....
Q5JJ68_THEKO/5-132 ...............e-DLLNKEIMRVNLHLPRQRVSLNEALRNGDGYVILRDGSMHYFRSSELEYLSDILEDDER....EKLKLPIILEIS.TV-.DRGYFR.VRGKIE..VKVIETILGQFd......pLEEKSEGRYPRYLLPRIRRILPTTTTYAF....
A0A2T9WZV6_9CREN/16-139 .............rwr-----EEVRRLQAHWPAEQVTLEELK--VRRSVSLADGTVHEMDPEEVERLLRIVPPYFR....PFMRVPLLLSYV.KEEdGAARYL.VMGDRW..QRRLAELMVRG.......dYSSEGVTELSVDEFVKLLREFRSLVF---vs..
Y452_PYRFU/5-132 ................DRIIQMEIGRINSHLPKARKSLCELLKEDSPSIELRDGSLHYFRRSELEFLKTLAGEE-A....CLVKLPIILELS.TL-.DRGYFV.VRGRGE..VRVIKKLLELSe.....diYLEENTVRLPRYYLPTIRRKLPTTTVYAF....
D7EA49_METEZ/15-143 ...............n-RWMNLEIGKINNSIVTARKTLYQLLEEDNPSSKTKDGREYLFKKEIINKLENRLPEHIQ....TRLKLPILFFFD.LQI.DDSCYI.NDKTAFeaLQILGEIGYKR........EFRNNRHWMGKAIAYSIKKKYPSAVQIV-m...
A0A2T9WTB8_9CREN/3-123 ................DKIFELGLRNSISFYPDEFVTIKEALEGKNYVTI-SGSYKHYFDKTELEKLSSKIPIYMW....DLVRIPFVIVKT.LNV.GE--YL.INGSDW.dKKAINILLNKQ........---EFSVCLYTGDVERLIKEFKSLIFI--t...
A0A8J7UQ99_9EURY/14-141 ...............k-KWISLEVGRIKDGLVAEKKSLARLLTESSPSAVTKGGKEHAFDREAVQMLGERLPEKFH....FRLMLPVTFYST.LDI.TDSYYL.RDETAFraLQALGELSEMR........EMREGKLWVSNAIVYAIMRKYPSLVE---ig..
A0A2H5V6T4_9ARCH/5-133 ................DDWLAETMRHVNDALPRRAEKLSTLLEMEKPSVETVGGGRHYFDKKELEELLRKLPSEVS....ENLYLPIVFAKN.PEL.GESTYI.VKSRGS.eAEAFRILMGLRt......lPRVGNQPYTYKPLVTEFINRYPTLA----vig.
H2C8G3_9CREN/3-121 ................DKIFNIGLKDLLDSMPAEYVTLKEALDGKVEIAL-NNGLKHRFDPEELRKISQSIPLYLW....SLVRIPLIFVKL.PSP.GE--YK.LNGSEW.dRRALSIILGKE........-----NSVLSGGQMESLLRQYKSLIFI--t...
F6BCS9_METIK/1-124 mdkeiyrliydlsprf-----------------KRKTLGELLNEDKPYII-VNGKRHRIKKRELLKLKEIASED--....--LEIPIVLEVD.ASL.ESGTIK.VSGKEA..VKVVSKILGREy.....npFSEEDVLYIYKPELRILRRELPTTTQLLF....
A0A2T9WY16_9CREN/3-122 ................DKIVELGLKSLLSYYPSERITLAEALKGKTVVRL-DDGSEIEIPRNIAEALGKSVPIYLW....DLVKLPIIITKS.GNN.GE--FV.VEDYKW.nREALKIVLNKE........----EVSVLRVGEVESLLRRFGTAIFI--n...
A0A110A343_THEX5/9-135 .............prd---ITRMLAHMNSNVPVKRRSLIDYIDNGGYTYETKGGDVCSFSKEGIDYLESICTEQEK....LTLKLPIFVSTD.PSS.ESGGWR.VDGRTE..VAVVARMLGKR........VHSEDRMSLYYPDLFQLKKLIPDLVYTLF....
N0BHL7_9EURY/4-130 ................ERALAKMIEAMNKHMPARRKTLKEMLNEDEPSIKARDGNEYIIEKDELKFISEYVDELDW....DKFNIPIILEMN.DLH.GETVVF.IRDKLH..QEFMRKAFGFD........RYVRDVMMIYLYEMRKVRRALRTASQVVF....
Q4J959_SULAC/3-124 ................DKVFDLGFKSLLSYYPDEFVTLKDALNGKLSIRLKSKDLRHRFDKLEVEKLSQVLPIYLW....DLVKLPFIVVKT.LNT.GE--YA.VSGSQW.eVRSLSIILQKE........---IKNTFLSTGDVEKLIKEYKSLIFI--t...
A3DNR3_STAMF/10-134 ................MRALSEELRIVNKHIVYSKKSLCDLLSMDVPYLILRDGSKSLIDRKELELLKNLVDGDP-....CKLMLPIIIEYN.PSL.GESAYV.VRDKVA..AKTLAKLLGLK........-YENGPLILYRPQLYMVRLKLRTVTTIVF....
D2RGG3_ARCPA/6-132 ..............ev--VLAKMIEAVNSHLPRRSRTLDEMLKEKYPTIVARDGNEYLIERKELEFIAKYLDEDEI....KKFRIPIVLEMH.TVG.NTYLIY.VRDKLH..AEFIKRAFGYD........RFVEDSLVLHMHEMASIRRVLRTATQVAF....
A0A133U4P2_9EURY/4-131 ................EKFLKKEIQSLNRHLPKGRTSLAKLLKQKKPQIETRDGSTHRFKKEELKYLAELLPEKKH....SKLRLPMIVRIS.PQL.GRGAAK.ISGKLE..QKILRKILDKK.......gEKNENELLIYRPEVRKIRQKLPTTTQYAF....
G7WLP2_METH6/5-134 ...............s-RVFAKLVRSLNDHLPVERKTLRELLGEEKPRIVCRDGSTHRIRREELETIERISR-LKWgkeaDKLKLPILIEMA.PDY.GRSAAR.IRGRVY..CDIVQEILKEE........RKTTDEMVIFRPDIRRLRRELPSATQYAF....
A0A483CRW3_9EURY/14-141 ...............r-RWMILEIGRINAGLVTERKSLARLLGEERPSATAKDGSDYRFDPAVIRDIGERLPADLH....ERLLLPIIFRFS.PDV.RDSYYL.TDAVAVraLQSLGELSEQR........KMRDGRLWVSNAIVFAMVRAYPTAIQI--g...
A0A656YWR5_9EURY/4-129 ...............d-EIIKKQIQNLNRHLPKGRISLEKLLEQDKPRVENRDGDTHRFKRRELEYLADLLPPEKH....SKLRLPIIVRIS.PEL.GRGASK.ISGKIE..REVIEKILEKE........-GDEDELVIYRPEIRKIRRKLPTTTQYAF....
A0A2U9IGE9_9CREN/3-122 ................DKIIDLGFKDILSSLPSEFVTLNDAVQGKNKIKL-KNGFIHEMDKNEILKLSNIIPLYLW....ALIKVPFIILKL.ETP.GE--YT.INGSEW.dKKALSIVLNKD........----TGKFISSLDVEKLMKDYKSLIFI--t...
E6N347_CALS0/5-133 ................DDWLAETMRHVNDALPRRAEKLSTLLEMEKPSVETVGGGRHYFDKKELEELLRKLPSEVS....ENLYLPIVFAKN.PEL.GESTYI.VKSRGS.eAEAFRILMGLRt......lPRVGNQPYTYKPLVTEFINRYPTLA----vig.
A0A6B9TB03_9ARCH/3-129 .............esf---VNSIMKDLNSNLAVNKRTIEQMMDSGDHTYRTRDGSVVEIPEEQLEFLWGVCDDRQR....ISLRLPIYVSTD.IGG.EGAAWK.VDGCVE..APVVAAILGKR........LHRDDYIRLYHPDLKDLRAKIPDCVMIVF....
F7XNU0_METZD/14-142 ................MRWMRVELGKLNRGVVANRKTLSQLLLEERPSSVTKSGDEYLFNEQIIEMLAEKLPGEIH....DNLKFPIFFFNT.IKV.DESCYL.NDKYALraLQILGELGESR........SLHEGKVWVGKSIAYSIMKKYPSAIQIV-v...
A0B7E5_METTP/7-135 ...............r-KILIKTIQTMNQHLPPKRKTLAELLEEERPGIKGKDNTFYVMDKPELELISKSIPRFMW....SRIRLPILIEMS.PEL.GSGSAR.IQGEAE..IEAVSKILNLKr......gDIGRRSMVIYLPDVRELRRKLPTTTQYAF....
A0A133VBB2_9EURY/4-130 ................DRFLRKQIQTLNRHLPKRRASLAKLLKEEKPQVTARDKTTHRFKKQELKYLAELLPKDLH....KRLRLPIIIRIS.PQL.GRGAAK.ISGKIE..RTVIEKILEKE........KSEEDELVIYRPEVRIVRKKLPTTTQYAF....
D9Q332_ACIS3/12-137 ..............tk--VYTEEVRRLQASWPSKQVRLREL--RDTDYIILNDGTSHEFDKDEVSRLLSQVPEYFW....DFMTVPLLLYYIrTES.GVAKYV.VVGNRW..QRRLAEIMLRG.......dYTAEGIGELSVDEFLVIIGKYRSLV----fvs.
Q6LYE3_METMP/2-124 ...............d-KEIYKFLHNLKSNF--KRKTLNELLKEDKPHLI-VNGQRHRIKKKELEFIKENISKD--....--IRLPIVLEVD.SSY.DSGTVK.IEGIEE..VKLISKILGKKv.....slFSEESILYIYKPELREVRRKLPTTTQYLF....
A0A656YWD3_9EURY/1-103 ...............m---------------------LSELLEEEEPSLEVEDGAPHKVKGEELEYLDEILEPEER....DRLRIPIYFRHT.GKE.ERGTYE.VKGDLE..QKVCAEVLNTE........----SKEYYYRPEVREIRRKLRTTTEYMF....
A4YHH7_METS5/3-121 ................DKIFQLGLRDILDSMPSEYITLKEAMDGKLEITL-NNGFKHKFDPEEVRKLSNAVPLYLW....SLVRIPFIVVKL.STP.GE--YS.INGSEW.dIKAISTLLNIS........-----GKVISVGQMESLLREFKSLIFI--t...
Q9Y9U4_AERPE/14-138 .............ryr-----ETAKRLAQNIPRETVTLYEASRG-RLTITLHSGEAHTLDKEEVERILEAAPPYFW....KLARIPIVLRYE.KTPsGVARYV.VQGDSW.qRRLVEIIVRGD........YTPQGLHELTVSQFQRIAARYRSIF----fvt.
A0A2V3JEA6_9EURY/7-140 ................ERVITKAIRALNRHLPAERKTLAALLREDKPAVRGRDNSIQRIRKEELKRIASLIPEEAY....QKLQIPVYIELT.PDY.GRGISR.IRGKIE..CELVRKILGLSser.vqgqGQSEDEIFIYRADVRKLRRELQTTTQYAF....
A0A0V8RUX9_PYROC/20-142 .....hmdkqffssir---------------PVEYKPLSVLLEEEKPSVRLASGSRHVLDRDDLERLRQRLPWYMH....SLVKLPFYFIYS.RVG.EVGQYR.LAGPDKwaAKALGLLLAGD........-ITVEKWRLTRSEMARLLSSFKTLI----ivs.
I7JAS8_METBM/14-142 ................MRWMRLEIGRINDGVVAERKRLSHLLREEHPSSVTKGGSEYNFDRDALLRMEQALPRDLQ....VRLRLPILFYFD.STV.PDSFFL.ADEAALqaLQCLEEISPLR........RMQGGRLWIAKPIVYAIMNRYPTAMQVM-m...
#=GC seq_cons .................+hlptplpplNpplPpcRpoLp-LLcp-cPplts+sGspHthc+cELchLuphlPppha....ppL+LPIllphs.sph.scushh.lpGcht..tcslpclLspc..........ppsplhlhcs-lpplh+chsTssphh.....
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