#=GF ID   DUF6137
#=GF AC   PF19634.3
#=GF DE   Family of unknown function (DUF6137)
#=GF AU   Williams LS;0000-0001-5551-8526
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Fragoso S;0000-0001-7018-3891
#=GF SE   Manual
#=GF GA   25.00 25.00;
#=GF TC   25.70 28.70;
#=GF NC   24.10 21.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   19362651
#=GF RT   Enzymology of aminoglycoside biosynthesis-deduction from gene
#=GF RT   clusters.
#=GF RA   Wehmeier UF, Piepersberg W;
#=GF RL   Methods Enzymol. 2009;459:459-491.
#=GF DR   INTERPRO; IPR046135;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents a member of a biosynthetic gene cluster
#=GF CC   (BGC). This BGC (BGC0000709) is described by MIBiG as an example
#=GF CC   of the following biosynthetic class, saccharide. It includes a
#=GF CC   member from  the neomycin biosynthetic gene cluster from
#=GF CC   Streptomyces fradiae  ATCC 10745 = DSM 40063 and appears to be
#=GF CC   predominantly found in  bacteria [1].             
#=GF SQ   13
#=GS W1J3T4_9GAMM/3-84        AC W1J3T4.1
#=GS A0A246J0V2_9BURK/1-82    AC A0A246J0V2.1
#=GS T0PCA1_PHOTE/1270-1351   AC T0PCA1.1
#=GS W0I3P3_9GAMM/1-82        AC W0I3P3.1
#=GS A0A151AXQ3_9CLOT/3-75    AC A0A151AXQ3.1
#=GS A0A1D8G9U3_9ACTN/1-74    AC A0A1D8G9U3.1
#=GS Q7MZW4_PHOLL/19-100      AC Q7MZW4.1
#=GS A0A839LDD1_9BURK/3-84    AC A0A839LDD1.1
#=GS A0A840QJ63_9PSEU/1-77    AC A0A840QJ63.1
#=GS A0A1Q4VWK1_9ACTN/26-107  AC A0A1Q4VWK1.1
#=GS A0A3D8JT46_9BURK/1-82    AC A0A3D8JT46.1
#=GS A0A2N7WB68_9BURK/1-82    AC A0A2N7WB68.1
#=GS F5LRB3_9BACL/9-82        AC F5LRB3.1
W1J3T4_9GAMM/3-84                   ...ISTSYIRQLIIKIACETTGD...DAKEVIE...RGRLEIPARDAIEFMVRLEALLDCTLSWSKYEHLSMEINNLVEIINNKLNAQSS-d................
A0A246J0V2_9BURK/1-82               ...MTPNQLRQLIIHTVCNVTGE...EPEEILA...HETVTLDTRDWEQVFSRLEATLDIDSGLLAGPRRSFEIDELTRDLHARLSGAAG-t................
T0PCA1_PHOTE/1270-1351              ...ISMNYIRQLIIKVACDTTGD...NAEELIE...RGRLEIPPRDAIEFVVRLEALFDCTLGWLRYEPLSIEINEFLAVVNNALNARES-l................
W0I3P3_9GAMM/1-82                   ...MTADYIRKLIYKIACDTTGE...AVEMINA...SGRLTIPARDAIEFMVRLEALLDCSLGWTRYQPLTISVDELTDIVHRAYHARAS-a................
A0A151AXQ3_9CLOT/3-75               ..y-SKNYFKNMIYKVCGDETNKffkDPERVVK...L----LDDREVVNIIQRLEAIFDCNLEWHN-------------------------dkidlkelenrlceiyn
A0A1D8G9U3_9ACTN/1-74               ..m-----TRMLVVKCLSDETGD...DAGDIVA...RGYVDVDDREFVNILNRLEGYFDCTLWMRSEPARRFAVGDLVERVAA--------vtap.............
Q7MZW4_PHOLL/19-100                 ...ISVNYIRQLIIKVACDTTGD...SVEELIG...RGRLEIPPRDAIEFMVRLEALFDCTLGCLRYEPLSIEIDEFSAIVNNALNVRVS-t................
A0A839LDD1_9BURK/3-84               ..l-SRQFIRQLIVQTLCTVTGE...EMQDILA...MDEVEVDTRDWEQIISRLEAFLDVSTGLLSSGQRVVRIDALAQDLFQRVHG----aggd.............
A0A840QJ63_9PSEU/1-77               ...MTDLFTDQLVLKCVCEETGE...EPADVLA...DGYVDVDPRDYVGVVHRLEAVFDRTLDLLDTNERRLVLADLRQRVRD--------ahp..............
A0A1Q4VWK1_9ACTN/26-107             ..r-GGDLTRMLVLKCLSDQTGD...SAEEIAA...AGYVEGDDRDYVEAVNRLESYFDCTLGLLGADGRRIVVEDVIARIPAGSGALAG-g................
A0A3D8JT46_9BURK/1-82               ...MTSTFIRQLIVHTICNVTGE...EPKTIVA...LDEVELNTRDWEQVFSRLEATLDIHTGMLSSTSRSISIDALADSLDTKLVGDII-l................
A0A2N7WB68_9BURK/1-82               ...MTSTFIRQLIIHTICNVTGN...EPTEIAA...LHRVELNTRDWEQVFSRLEAALDIHTRMLTSTERSICIDTLTQTLHAKVAGNII-s................
F5LRB3_9BACL/9-82                   lyq---------VIYAISGVTGE...DGDELVEtfkQGPMEVDKRDFFEIIQRVESLFDCTLDMNLEGPYLIHADEIATKIT---------klnv.............
#=GC seq_cons                       ...hossalRQLIlKslC-sTG-...-sc-llA...pGplElssRDalplhsRLEAhhDCoLuhLststhslpl--Lspplpsthtu....s................
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