#=GF ID   DUF6181
#=GF AC   PF19679.3
#=GF DE   Family of unknown function (DUF6181)
#=GF AU   Williams LS;0000-0001-5551-8526
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Fragoso S;0000-0001-7018-3891
#=GF SE   Manual
#=GF GA   25.00 25.00;
#=GF TC   25.00 140.90;
#=GF NC   24.30 22.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   16766657
#=GF RT   Amplification of the entire kanamycin biosynthetic gene cluster
#=GF RT   during empirical  strain improvement of Streptomyces
#=GF RT   kanamyceticus.
#=GF RA   Yanai K, Murakami T, Bibb M;
#=GF RL   Proc Natl Acad Sci U S A. 2006;103:9661-9666.
#=GF DR   INTERPRO; IPR045753;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents a member of a biosynthetic gene cluster
#=GF CC   (BGC). This BGC (BGC0000703) is described by MIBiG as an example
#=GF CC   of the following biosynthetic class, saccharide. It includes a
#=GF CC   member from  the kanamycin biosynthetic gene cluster from
#=GF CC   Streptomyces  kanamyceticus [1]. 
#=GF SQ   12
#=GS A0A1G9F3Y2_9ACTN/1-132   AC A0A1G9F3Y2.1
#=GS A0A7H8NAN2_9ACTN/1-132   AC A0A7H8NAN2.1
#=GS A0A6B2RMK7_9ACTN/1-132   AC A0A6B2RMK7.1
#=GS A0A6I6SKM0_9ACTN/1-132   AC A0A6I6SKM0.1
#=GS A0A117RN64_9ACTN/1-133   AC A0A117RN64.1
#=GS A0A1V4A2I9_9ACTN/1-132   AC A0A1V4A2I9.1
#=GS A0A291W5K9_9ACTN/36-168  AC A0A291W5K9.1
#=GS A0A429NGR0_9ACTN/1-135   AC A0A429NGR0.1
#=GS A0A646KST0_STRJU/1-126   AC A0A646KST0.1
#=GS A0A7X6HWX3_9ACTN/1-132   AC A0A7X6HWX3.1
#=GS A0A7V8SUG2_9ACTN/1-132   AC A0A7V8SUG2.1
#=GS A0A1Q5LK87_9ACTN/1-81    AC A0A1Q5LK87.1
A0A1G9F3Y2_9ACTN/1-132              ..MDETTQDRSTTRMPSRRGAATPSR.DGVHRLSVPLHPRLSATELIRVLLAAPGETDLSALDPVQVRSLIADVLTQHGYDVLDRSPYYPELDRHQDARRAVRRAYGPRFLDAPDEQAVLADPLREVLAAG------srks.
A0A7H8NAN2_9ACTN/1-132              ..MDETTEDRSTTRAPSRRGAATPSR.DGVHRLSVPLHPRLSATELIRVLLAAPGETDFSALDPVQVRSLIADVLTQRGYDVLDRSPYDPELDRHQDARRAVRRAYGPRFLDAPDEQAALADPLREVLTA--GS---rtp..
A0A6B2RMK7_9ACTN/1-132              ..MDETTEDRSTTRTPSRRGAATPSR.DGVHRLSVPLHPRLSATELIRVLLAAPGETDLSTLDPVRVRSVIADVLTQHGYGVLDRSPYYPELDRHQDARRAVRRAYGPRFLDAPDEQAVLADPLREVLAA--GS---rtp..
A0A6I6SKM0_9ACTN/1-132              ..MDETTEARSTTRTPSRRGAATPSR.DGVHRVGVPLQPRLTAAELIRVLLAAPGETDLTALDPVRVRSLISAVLTQHGYDVLDRSPYYPELDRHQDARRAVRRAYGSRFLDAPDEQAVLADPLREVLAA-------agggp
A0A117RN64_9ACTN/1-133              ..MDETTDHRSTTRTPSRRGAATPSR.DGVHRLSVPLHPRLSAAELIRVLLAAPVETDLHTLDPVRVRSLIADVLTQHGYAVLDRSPYYPELARHQDARRAVRRAYGPRFHDAPDEQTVLADPLREVLAAA------gggks
A0A1V4A2I9_9ACTN/1-132              ..MDETTEDRSTTRTPSRRGAATPSR.DGVHRLSVPLHPRLSATELIRVLLAAPGEADLSTLDPVHVRSLIADVLTQHGYDVLDRSPYYPELDRHQDARRAVRRAYGPRFLDAPDEQAVLADPLREVLAA--GS---rtp..
A0A291W5K9_9ACTN/36-168             ..MHTAKTPTTTPQTPSRRGAAQPSR.DGIARIGISLQLRFSASELTSALVAAPAEHDLSALGPVDVRRLVAEVLAQYGYDVLSRAAYDSNDDRHQEARRAIRRAYGPRFTNAPDEQAFLAAPLLDVVRADLWE---qp...
A0A429NGR0_9ACTN/1-135              ..MHHTKEATETHSSPRRRGAAQPSKgDGVFRVAVPLRPRLSASELTRALLAARKSEDLDTLRSVQIRALIAEVLTRHGYDLLDRSAYDPHDPRHQAARRAVRRAYGSRFVGAPDEMRFLAEPLTEVFRDGFGHGRA.....
A0A646KST0_STRJU/1-126              ms----------PRTLTRRGAAQPSK.DGVARIAVPLHPRLSASELTRVLAAAPADHDLTVLDPVETRALIAEVLTQHGYDVLRRTPYDSNDDRHQAARRAVRAAYGHRFTDAPAEQAFLADPLLDIVRAGLWREE-p....
A0A7X6HWX3_9ACTN/1-132              ..MDETTDHRTPTRTPSRRGAATPSR.DGIHRLTVPLHPRLSATELIRVLLAAPGETDLTALDPVAVRALIADVLTRHGDAVLDRSQYHPELDHHQDARRAVRRAYGPRFLDAPDEQAVLADPLREVLAA-------tsrtp
A0A7V8SUG2_9ACTN/1-132              ..MDETTEDRSTTRTPSRRGAATPSR.DGVHRLSVPLHPRLSATELIRVLLAAPGETDLSTLDPVEVRSLIADVLTQHGYDVLDRSPYYPELDRHQDARRAVRRAYGPRFLDALDEQTVLADPLREVLAA--GS---rkp..
A0A1Q5LK87_9ACTN/1-81               .m------------------------.----------------------------ETDLSTLDPVQTRSLIADVLTQHGYDVLDRSPYYPELDRHQEALRAVRRAYGPRFLDAPDEQAVLADPLREVLAAGSG----ks...
#=GC seq_cons                       ..MDETT-sRoTTRTPSRRGAATPSR.DGVHRluVPLHPRLSAoELIRVLLAAPuETDLosLDPVpVRSLIADVLTQHGYDVLDRSPYaPELDRHQDARRAVRRAYGPRFLDAPDEQAVLADPLREVLAA..h....ps...
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