#=GF ID   DUF6187
#=GF AC   PF19685.3
#=GF DE   Family of unknown function (DUF6187)
#=GF AU   Williams LS;0000-0001-5551-8526
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Fragoso S;0000-0001-7018-3891
#=GF SE   Manual
#=GF GA   25.00 25.00;
#=GF TC   25.30 41.80;
#=GF NC   24.70 22.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   29090939
#=GF RT   Amycolamycins A and B, Two Enediyne-Derived Compounds from a
#=GF RT   Locust-Associated Actinomycete.
#=GF RA   Ma SY, Xiao YS, Zhang B, Shao FL, Guo ZK, Zhang JJ, Jiao RH, Sun
#=GF RA   Y, Xu Q, Tan RX, Ge HM;
#=GF RL   Org Lett. 2017;19:6208-6211.
#=GF DR   INTERPRO; IPR046178;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents a member of a biosynthetic gene cluster
#=GF CC   (BGC). This BGC (BGC0001503) is described by MIBiG as an example
#=GF CC   of the following biosynthetic class, polyketide. It includes a
#=GF CC   member from  the amycolamycin A biosynthetic gene cluster from
#=GF CC   Amycolatopsis sp. [1]. This family appears to be predominantly
#=GF CC   found in  Actinobacteria.
#=GF SQ   17
#=GS A0A4R7UYC1_9PSEU/4-153  AC A0A4R7UYC1.1
#=GS A0A6B2DK36_9PSEU/1-60   AC A0A6B2DK36.1
#=GS A0A1H0UW48_9PSEU/1-141  AC A0A1H0UW48.1
#=GS A0A2S9Q2E9_9ACTN/1-128  AC A0A2S9Q2E9.1
#=GS A0A7Z1B0H7_9PSEU/6-145  AC A0A7Z1B0H7.1
#=GS A0A1Q5KHB1_9ACTN/7-149  AC A0A1Q5KHB1.1
#=GS A0A1Q8C7I4_9PSEU/7-95   AC A0A1Q8C7I4.1
#=GS R4T0C9_9PSEU/4-143      AC R4T0C9.1
#=GS A0A7W7Q9U5_9PSEU/3-141  AC A0A7W7Q9U5.1
#=GS A0A7G7BWB6_9ACTN/1-107  AC A0A7G7BWB6.1
#=GS A0A344LHA3_9PSEU/4-140  AC A0A344LHA3.1
#=GS G0G2F9_AMYMS/4-143      AC G0G2F9.1
#=GS A0A1Q4Z882_9ACTN/6-148  AC A0A1Q4Z882.1
#=GS A0A0H5CIP4_9PSEU/1-141  AC A0A0H5CIP4.1
#=GS A0A1Q8CA83_9PSEU/1-67   AC A0A1Q8CA83.1
#=GS M3BQN3_STRMB/5-140      AC M3BQN3.1
#=GS A0A1H3D7B4_9PSEU/3-139  AC A0A1H3D7B4.1
A0A4R7UYC1_9PSEU/4-153             .....q-YDTIFGLPSVDDEPDTEVGVLLMGLGPERLLAGLGVACRdpVAD..PAAVTLVVDQLRHGA.RQAGeYERVIADGVTRWRAASAGIARAGL.H.PgPRSAALRRLWTNAASALADADgvdglRT...AGAGERVYLTACWLRPEEINRMTEENGG--ts.
A0A6B2DK36_9PSEU/1-60              ....lg----------------------------------------..---..---------------.----.---------------------DPP.S.T.STPGSLRREWDRTSARVAAAV.....PG...AGAASLAYLTACVLRRTDVDRIADRKD---tdv
A0A1H0UW48_9PSEU/1-141             ......MSDTSFDLPALDDPASTETGIMLLGLDPDRLLACLAVVTL..ADD..AGQVAMLVDHVRHGG.AELT.MPDLVAAGARRWRSIRPELADADP.S.P.STSASLRQAWERSHRTLTTVF.....ST...VGPAGVVYLTACWLRRADIDNLVATLGGT-p..
A0A2S9Q2E9_9ACTN/1-128             .....m----------------TETGVMLMGLEAERLLAGLGLATL..ADD..PAQVLLTVDRIRHGVrATMT.FEALVGAGARRWREARPVLAATGG.A.A.ATPVALRRAWDETLRLFAHCD.....LG..aPGPATTAHLAACWLRRNEIDQFTQRTVHG-e..
A0A7Z1B0H7_9PSEU/6-145             .....p-YDTVFSLPSVDDDAETEIGVLLMGLGPERLLAGLGVACL..RGDagPAEVTLVVDQLRHDAgGDLA.LADALRAGAARWRVAHAALAGVVP.G.-.VRSASLRQQLAAASAEITGIA.....--...GSPAQRLYLVVCWLRCAEITRTAEEH----gvf
A0A1Q5KHB1_9ACTN/7-149             .....s-FDTRFSLTPVDESGTTETGVLLMGLEAERLLAGLGLAAL..ADD..PAQVLIAVDRIRHGVrATMT.FEALVEAGAQRWRETRPALAAAVG.P.A.SPPAALRKALKDTLRIFAHCD.....LG..dPGPATSAHLAACWLRRNEIDRLAQCPAHG-e..
A0A1Q8C7I4_9PSEU/7-95              .....g-YDTAFSLPSVDDDPDTELGVLLMGLESPRLLAGLGVAVLgeAGD..PVSATLLVDQLRHGTrDHPT.LASAVAAGAGRWRAVRPALAAAD-.-.-.---------------------.....--...------------------------------a..
R4T0C9_9PSEU/4-143                 .....p-YDSRFTLPSIDDAPSTESGVILLGLDAERLLAGVGLARL..ADE..PALVALAVDQARHEA.LDLG.LGALVEAGIVRWRAVRP-LIEAGP.E.M.TAAGSLRREWEHATARVTATV.....TG...LGPASVACLAACWLRRDDVDEFAAHGRA--pe.
A0A7W7Q9U5_9PSEU/3-141             .....e-YDTVFSLPSVDEDPDTELGVLLMGLGPERLLAALGVAGP..ARD..PATALLVVDQLRHDArPDLT.FEAALAAGAGRWRAVRPRLAAAAPaN.E.VRSAALRKLWAAATHTVTEAG.....VA...IDRAGLVYLSACWLRRDEIDDTARR-----h..
A0A7G7BWB6_9ACTN/1-107             ......------------------------------------MASL..AED..PAQIVLAVDRARHDVrTSLT.FDALVEAGTQRWRSVRPALAAAGE.A.P.LSPTALRSAWNRALRMVGHHG.....IG..rPDSAAAAHLAACWLRREEIDTRAARPV---reg
A0A344LHA3_9PSEU/4-140             .....t-HDTRFTLPAVDGPASTETGVILMGLDARRLLAGLGLASL..FDD..PGQVTLAVDHARHDApLQFS.LDALVAAGATRWLAARDALAAAGG.P.P.ADFASLRLAWEQTLRLLAGCD.....LG..dAGPATVAYLAACWLRREEIDRH--------sd.
G0G2F9_AMYMS/4-143                 .....r-GDLRFVLPDVEAPAAVEAGVILLGLDADRLLAGLGLARL..ADD..AALVTQVVDQARHEA.GGFG.FAALVASGAGCWRELRA-FAGDGR.S.T.ASPGALRREWEVAHALATAAV.....PG...AGAATIAHLTACSLRRADVDPLADRYADG-t..
A0A1Q4Z882_9ACTN/6-148             .....g-YDSRFSLTAVDEPALTETGVMLMGLDAERLLAGLGLATL..ADD..PAQVALAVDRVRHDVpAFPG.FDALVDVGARHWRSTRAVIAAAGS.R.P.PAPASLRRAWDETLRMLTYCD.....LG..dSGSATIAHLAACWLRQEEIDRFARRPAL--tg.
A0A0H5CIP4_9PSEU/1-141             ......MSDTRFTLPAIDAPASTETGVMLLGLDPERLLACLAVVTL..ADD..PGQVAMLVDHVRHGG.AHLT.MPDLITAGAHHWRTIRPDLAAADP.N.P.VVSAAVRQTWDRAHTAIAAEL.....TT...VGPARLVYLTVCWLRRADIDPVAALSGGE-p..
A0A1Q8CA83_9PSEU/1-67              ......----------------------------------------..---..---------------.----.---------------RPALAAADA.GgG.TRSAALRQQWSAAERVVAAAE.....RRtgpAGHAERVYLTVCWLRRNEIDRAAEDE----acr
M3BQN3_STRMB/5-140                 dykgae--------------SALEPQLIVLGTESERIFAALGMTTH..LRS..LGEVMLGAERAEHTGsWSLN.WMEAVERGIHFWETFRNRFTSARL.DgI.RRNGAPRENLARCGTAVATEL.....GL..pADDPLVALLAVAMIRREEFDDYVQKNAK--ga.
A0A1H3D7B4_9PSEU/3-139             .....d-HDTRFSLPGVDDPPSTEAGVILMGLDAERLLAGLGLAML..ADD..PALVTLAVDRVRHGAmTQFT.AAGLVETGAARWLALRPALAETGI.P.S.TTNGSLRRSWEHTLRVVTGVH.....PG...LGPGSAAYLTACWFRRDEVDALAA------p..
#=GC seq_cons                      ........DohFsLsslDtsssTEsGVhLhGL-s-RLLAuLGlAsL..AcD..PupVsLsVDphRHss.sphs.htslVtuGAtRWRshRssLAuAss.s.s.sssuuLRptWppshphlssss.....hs...sGsAshsaLsACWLRRsEIDphAtc.....s..
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