#=GF ID   DUF6190
#=GF AC   PF19689.3
#=GF DE   Family of unknown function (DUF6190)
#=GF AU   Williams LS;0000-0001-5551-8526
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Fragoso S;0000-0001-7018-3891
#=GF SE   Manual
#=GF GA   25.00 25.00;
#=GF TC   29.20 64.90;
#=GF NC   22.70 21.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR045685;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents a member of a biosynthetic gene cluster
#=GF CC   (BGC). This BGC (BGC0002018) is described by MIBiG as an example
#=GF CC   of the following biosynthetic class, other (unspecified). It
#=GF CC   includes a  member from the azomycin biosynthetic gene cluster
#=GF CC   from Streptomyces cattleya NRRL 8057 = DSM 46488. This family
#=GF CC   appears to be  predominantly found in bacteria.
#=GF SQ   33
#=GS A0A0T6LV54_STRVM/1-151   AC A0A0T6LV54.1
#=GS A0A0B6RJX0_BURPL/1-167   AC A0A0B6RJX0.1
#=GS A0A6H0CF11_9ACTN/1-176   AC A0A6H0CF11.1
#=GS A0A1Z2KZ21_9ACTN/11-178  AC A0A1Z2KZ21.1
#=GS A0A2S4Y377_9ACTN/1-170   AC A0A2S4Y377.1
#=GS A0A157SRP0_9BORD/1-126   AC A0A157SRP0.1
#=GS A0A1Z2KW52_9ACTN/1-167   AC A0A1Z2KW52.1
#=GS A0A841G277_9ACTN/1-164   AC A0A841G277.1
#=GS B4VCE9_9ACTN/1-170       AC B4VCE9.1
#=GS W7SSC9_9PSEU/1-161       AC W7SSC9.1
#=GS A0A429RGJ6_9ACTN/10-179  AC A0A429RGJ6.1
#=GS A0A202DEY3_9ARCH/1-91    AC A0A202DEY3.1
#=GS C5ADX4_BURGB/1-167       AC C5ADX4.1
#=GS A0A369TB47_9PROT/4-172   AC A0A369TB47.1
#=GS A0A7W7U5T5_9ACTN/4-177   AC A0A7W7U5T5.1
#=GS A0A6M8MLZ3_9PSED/1-167   AC A0A6M8MLZ3.1
#=GS A0A429QXX5_9ACTN/1-177   AC A0A429QXX5.1
#=GS A0A495X4F0_9PSEU/1-160   AC A0A495X4F0.1
#=GS Q87YD4_PSESM/1-173       AC Q87YD4.1
#=GS A0A399G3P2_9ACTN/1-164   AC A0A399G3P2.1
#=GS A0A7K2L055_9ACTN/1-181   AC A0A7K2L055.1
#=GS A0A561UPC3_9ACTN/1-165   AC A0A561UPC3.1
#=GS K4IES3_PSYTT/1-160       AC K4IES3.1
#=GS A0A7K2XHW3_9ACTN/1-135   AC A0A7K2XHW3.1
#=GS A0A2A3XDJ6_9GAMM/1-165   AC A0A2A3XDJ6.1
#=GS A0A285N8S9_9PSED/1-167   AC A0A285N8S9.1
#=GS A0A1N7EDS0_9ACTN/1-168   AC A0A1N7EDS0.1
#=GS A0A5B2X672_9PSEU/1-164   AC A0A5B2X672.1
#=GS A0A1H9WH41_9PSEU/1-167   AC A0A1H9WH41.1
#=GS A0A0M8WEL1_9NOCA/1-168   AC A0A0M8WEL1.1
#=GS F8JPS0_STREN/1-170       AC F8JPS0.1
#=GS F2RE62_STRVP/1-180       AC F2RE62.1
#=GS A0A419HWZ6_9PSEU/1-163   AC A0A419HWZ6.1
A0A0T6LV54_STRVM/1-151              ..........---------------MHSTDPVTRAACKGFFVTHL..HLP....TVMTYEEVGRCDDVVWG..RPRRIQDLYYPFMDVLHSVLDVRRRGYQVSDLTHL-.DAHPLT.GLRPRERLLLSVVSATGGRLVTVNPRLLRasSA..GLP..VCSP........RPSQETAP........FPD...ELESLYRQSLALEVDHAE-v..........
A0A0B6RJX0_BURPL/1-167              ..........MRNTMPFIDASLFLGMHHADRVIRTRSLDFFHGHF..TIG....ARMNFEQIGICDSVIWR..QPRETQDDYYPFMDVLHTDMTFVRQGYETRHLLTAY.SDERLA.HLRAEQKLLVAQVLAAEAKLYTHDPALRS..--..-LP..CLAEhl...gsfDEASAAGS........FPT...ELENLYHRSKAFLLTGEE-w..........
A0A6H0CF11_9ACTN/1-176              mpadtpdapd---REVFVDAALFLGMHSQDDGLRVACKAFFVERL..DTR....VVMNLEQVGRCDDVIWS..YSRELQDLYYPFMDQLHTVMDISREGYDRADVGLAL.SDPALSgQLPFSDRLLVAMVVNRKGLLHTVGPRGDA..FG..GLP..VRAV........AAWPADVPe.....pvFPE...PLERLYRASLALRLPP---drl........
A0A1Z2KZ21_9ACTN/11-178             ..gaaagaga-----AYADAALFMGMNSADDKVRIACKAFFAERL..GGR....VRMSWEQVGRCDDLVWR..FPREAQDAYYPFMDNLHTDMRIERRAYEPADLRHGL.GTAAWA.DLPTHERLLLGMVHGSGGVLYSVSPRLSG..RD..DLP..VRVP........APPGTEPL........FPE...PLERLYQASLALRLPTEA-l..........
A0A2S4Y377_9ACTN/1-170              ..........MARD-LYVDAALFMGMHSTDTAVRDACAAFFAAHL..ERP....LVMTYEEVGRCDDVVWG..YPRAAQDAYYPFMDLLHSVMPVRRRAYTADDWLAFDrLPAPAT.ALSPRERMLLAAVSAGGGELVTVNPRLLAltTP..GLP..VRGP........EPAAGPVR........FPDgtgTLDKLYDVSLELVVDHAA-v..........
A0A157SRP0_9BORD/1-126              ..........-----------------------------------..---....--MTYEQIGICDAVIWG..QDRHTQDLYYPFMDRLHTDMAIQRGGYTYSEIRAAL.EHHDLI.QLPPETALLAAQVLYHEALLATHDRALLA..LP..SLQ..GRIId......lGQNAEPVE........FPE...PLRTLYDESTVFVYDE---qh.........
A0A1Z2KW52_9ACTN/1-167              ..........MAPE-VFLDASLFMGMHSTDPSLRAAATAFFAAHL..ERP....VVMTYEEVGRCDDYVWR..FPREVQDAYYPFMDVLHSLMPIRRRAYDADVLAALPgLPSQAE.ELRPRDRLLLASVVAAGGELVTLNPRLTA..LTglGLP..VRTP........GPAADRGI........FPA...DLDKLYEQSLVLEADHAE-l..........
A0A841G277_9ACTN/1-164              ..........MAAE-IVIDAALFMGMHAAEESARLACKSFFTSNL..ATP....MLMPLEQVGLCDDLIWR..LPRDTQDAYYPFMDNLHSLLCVERPGYGRGDAEIGF.GSAALD.GLPDHERLLLGFVLRKGGTLHTASPRLTG..RT..GLP..VRGI........ETPGADRA........FPK...TLETLYEQSLKLTVPAAD-l..........
B4VCE9_9ACTN/1-170                  ....mpadps----DVFIDATVFMGMHSGDQAVRRACKRFFIERL..AGG....VTMSWEQVGRCDDLVWG..YDRDVQDAYYPFMDVLHTEMAIARIGYGEEDTRLAF.TTTALE.GLPSHERLLLGQVLSRSGLLYTASPRLTG..RS..GLP..VAAV........PAAPGEGAe.....dvFPG...HLEKLYQDSLVLTVDSHT-l..........
W7SSC9_9PSEU/1-161                  ........mr-----EVIDAATFMGMHCADERIRLACKAFFVERL..DGS....VLMSQEQVGRCDALVWT..YGRADQDAYYPFMDNLHTVVRIERPAYTEEDVRTAL.DEPALK.ELPMHERLLMGMVIATGSVLRTPNPRLAA..RA..DLP..VRPL........PAAA-NTA........FPE...PLERMYAESLALSVPTD--fl.........
A0A429RGJ6_9ACTN/10-179             ...gaeaard-----DFIDASLFLGMHSADEGLRIAAKAFFVRRL..EGR....VVMSLEQVGRCDDVIWG..YSRELQDLYYPFMDHLHTVMDISREGYDQADVRLALsESDTPQ.QLPFIDRMLIGQVINRKGLLHTAGPRSAA..FE..GLP..VRAVa.....awPAGEPEPS........FPE...PLERLYLTSLALRLP----sgr........
A0A202DEY3_9ARCH/1-91               ......mkei------TITKEMLLGLHSTDEKTRIKVKNYIILAIlkKQK....FYMSFEDVGICDDYIWThhKNKEEQDTYWPFLYYLHTHHIVR-------------.------.-----------------------------..--..---..----........--------........---...-------------------gkeqkeaekiv
C5ADX4_BURGB/1-167                  ..........MRNAMPFIDASLFLGMHHGDRVIRTRSLNFFHGHY..TIG....ARMNFEQIGICDSVIWR..QPRETQDDYYPFMDVLHTDMTFVRQGYETRHLQTAY.SDARLA.HLRAEQKLLAAQVMAAEAKLYTHDPALRS..--..-LP..CLADhl...gsfDESSAAGS........FPT...ELENLYHRSKAFVLTGEE-w..........
A0A369TB47_9PROT/4-172              ..pakgapap----AVYIDAGVFLGMNSSDEQVRIASKNLFIRRW..SDG....LHMTLDQVGICDAIVWL..RTREVQDDYYPFMDQLHTLMRIDRVPFSAADIAAAA.GDRTLD.GLSPHARLMLAKVRGDDATLLSWDPALQQ..RF..DLE..VAGP........DDGDPEQQ........FPG...ELEALYQRSLVLRLSLDE-v..........
A0A7W7U5T5_9ACTN/4-177              dapdatdhap----TVFIDATLFMGMHSTDDAVRTGAKAFFAGRL..AAGdagrVVMNWEQVGRCDDLVWG..YERKIQDEYYPFMDVLHTDLAIDRVPYDEDDLRQAF.TTPALE.GLPTHERLLLAQVIGRGGELHTASPRLLR..TT..GLP..VVPV........GATAEPS-........FPA...YLEDLYRRSLVLTVDSDT-l..........
A0A6M8MLZ3_9PSED/1-167              ..........MLEEAPMIDATVFMGMHHQNADIRAKSLGFFTRRY..HSE....VRMSFSQIGVCDAIIWK..KARELQDVYYPFMDVLHSDMNILRAGYSDAALTRAA.SSPALA.GLSAEKRLQAAQVLEADCLFYTHDRDYQN..CA..ALK..PHLAs......fDAASGVHG........FPD...GLQRLYNASLELVIAEED-y..........
A0A429QXX5_9ACTN/1-177              ...mrpdats----EVFIDATLFMGMHSEDDAVRVASKAFFADRL..AAGtagrVVMSWEQVGRCDDLVWA..YERGVQDDYYPFMDVLHTDLEIDRIAYEEADVRRAF.TAPGLD.GLPTHERLLLAQVIGRGGTLHTASPRLLG..TA..GLP..VVPIar....agA----PAPva...epsFPP...YLEDLYRRSLVLTVASED-l..........
A0A495X4F0_9PSEU/1-160              ..........MSGE-AIIDASLFMAMNSKDEATRRRGKAFFVARL..ATG....AVMPLEQVGACDDLVWG..YSRAEQDAYYPFMDVLHTEMKIDRIGYTEEDLKRAL.ESPELA.GLSLRNRLTVAVVLNRGGTLYTVDPELTA..RD..DLP..LGEL........--PDVESA........FPQ...PLEGLYKQSLVLRV-----ggg........
Q87YD4_PSESM/1-173                  msersmsnlr----LPMIDATVFMGMHHADPGVRDKCLGFFSRFY..TSS....VQMNFAQVGICDAIIWK..KSRALQDVYYPFMDVLHTDMAIQRQGCSEQVLQRAA.NDSLFK.GLPAEKKLLAAQVLEHELPFYTHDLELLR..--..-LQ..VLQPfl...qpfENTPERPA........FPE...MLQRLYEQSCALVIRNED-f..........
A0A399G3P2_9ACTN/1-164              ..........MSGD-VFVDAALFMGMHSRDAELRNACKRFFADRI..DGR....VVMSLEQVGRCDDLVWG..YPREVQDAYYPFMDRLHTDMEIHRVGYDEKDVRAAW.DDPRLH.GLPAHERLAVAQALNRGGRLHTASPRLAA..RT..DLP..VEAV........GPLAWEPS........FPD...HLERHYRDSLVLTVVADQ-l..........
A0A7K2L055_9ACTN/1-181              ....mpadlg---QAVFIDATTFMGMHSKDDAVRVAAKAFFAGRL..AAGeaggVVMSWEQVGRCDDLVWG..YERGLQDEYYPFMDVLHTDLAIDRIPYTEDDVRRAF.DEPALD.GLPAHERLLLSQVIGRGGVLHTASPRLVR.aAA..ALP..VAPLvpldpadaPA-----Sge...epsFPA...YLEDLYQRSLVLKVVSET-l..........
A0A561UPC3_9ACTN/1-165              ...mraeqsg----AEFVDAALFLGMNSADERTRIACKSYFAARL..TGR....VTMSLEQVGRCDDLVWR..FPRQVQDAYYPFMDVLHTDMAIDRVPYEAADLSRGL.A--EET.GLPMHERLLLAMVRNRRGTLRTVSPRLLG..GP..DGQ..VLAP........PAGP-ELA........FPE...PLEGLYQQSLVLRLPVD--al.........
K4IES3_PSYTT/1-160                  ........mn-----EFIDASVFLGMHSEEENIRIKCKNFFVKRM..KKE....IIMSFETIGECDHIIWG..FSRLHQDSYYPFMDRLHTIMKIKRIPYGLKEVNLMS.IDKNLQ.NYKPG--LNLALSITHRGVFYTLNQKLIS..SS..IDN..IKTI........PDEEVELM........FPK...DLEKYYEESLILKLS----vfdf.......
A0A7K2XHW3_9ACTN/1-135              ....mrpdtd---AVTFVDAALFMGMHSEDDAVRRAAKAFFIGRL..AAGkagrVVMSWEQVGRCDDLVWG..YDRKAQDEYYPFMDVLHTDLAVERTGYEEADVRRAF.TAPELD.GLPAHERLLLAQVVHRGGVLHTASPRLLR..--..---..----........--------........---...-------------------ta.........
A0A2A3XDJ6_9GAMM/1-165              ........mv-----PIIDASVFLGMHHESLEVREKCVEIIVRNF..DGG....LEINLEQIGLCDNVIWQ..RSREEQNAYYPFMSYLHTVMEFKRIPYADEAYQLAA.IDYRLK.HLPMKKAILACHVLAGERGLYTLDDDLKD..MD..-LL..SDYImp....iiSSSETEYF........FSE...PLNLFYKKSLMLKLKSEE-i..........
A0A285N8S9_9PSED/1-167              ..........MPDAIPIIDASWFMGMHHENSHVRARSLAFFTQHY..HRQ....AWMSFSQVGICDAIIWK..KSRELQDLYYPFMDVLHSQMRIQRAGYSEAALQRAA.TCDALA.GLSPEKRLLAAQVLDCQAPFHTNDQDYLG..CP..ALKpwLVAP........EASPVPGH........FPD...SLQQLYEASLALSIQAQEL...........
A0A1N7EDS0_9ACTN/1-168              ..........MSGE-PFLDAALFMGMHSRDDEVRRGCKRFFTERL..SGG...rVLMSLEHVGRCDDLVWR..YPRRVQDEYYPFMDNLHSDMAIDRIGYDEQDLRLAL.EAGVLS.DLPLHERLLVAMAMRRDTVVVTASPRLSL..RP..DLP..VRPV........EPAKPADDe.....pvFPA...PLERLYERSLALRVDVDD-l..........
A0A5B2X672_9PSEU/1-164              ..........MSGE-AFIDASLFMGMHSSDDRIRRSCKRFFVERL..ETG....AVMSLEQVGRCDDLVWG..FPREVQDAYYPFMDVLHTDMKIDRIGYADADLALAAaPGQELT.GLPVTDRLTLAMVLNRGARLHTVNPRLVG..RA..GLP..LDPL........-PEDAESV........FPP...ELEQLYQDSLVLSVAPDD-v..........
A0A1H9WH41_9PSEU/1-167              ..mapatlva-----EFVDAALFMGMHSADERIRLACKGFFVDRL..ATG....VVMSLEQVGRCDDIVWS..YPREVQDAYYPFMDNLHTDMTVSRVGYTATDVTAAL.GFTDLA.HLPLTERLTVSQVVARGGTLFTVDSRYPT..GG..GLP..VRGP........DRVDTEPA........FPD...KLEQLYRESLVLRVAH---sp.........
A0A0M8WEL1_9NOCA/1-168              ..........MSAE-AMIDASLFMGMHSTDDTVRGRCKSFFAQRL..TGR....VSMSLEHVGFCDNLVWS..YPRAEQDAYYPFMDVLHTDMRIDRIGYEETDLKFAL.DTAWPP.DLPWHERLLLAMATRLGAVVHTASSRLTG..RT..DLP..AAVVs.....vlNTAQDSAV.......dFPE...PLERLYADSLALRVAPE--rv.........
F8JPS0_STREN/1-170                  ..maadregp----RAFVDAALFMGMHSTDDAVRIACKAFFVGRL..HDR....VAMSLEQVGRCDDLVWG..FPRHVQDAYYPFMDNLHTDMRVDRCGYDLADVRHALdGAPEPA.ELPGHERLLIAMVGHRQGVLHTVSPRLLA..HP..GLP..VVAP........ARPAYEPS........FPE...PLERLYQVSLALRVTAAQ-l..........
F2RE62_STRVP/1-180                  ...mrsdanp----VAFIDATAFMGMHSEDDAVRVAAKAFFADRL..AAGdagaVVMSWEQVGRCDDLVWG..YERGVQDEYYPFMDVLHTDLAVDRVPYTEDDVRRAF.TEPALD.GLPTHERLLLAQVIGRGGVLHTASPRLTG..AA..GLP..VVPLapp..apaG------ApapgeepsFPA...YLEDLYQRSLVLTVVSEN-l..........
A0A419HWZ6_9PSEU/1-163              ..........MSPE-IVIDASLFMGMHSTDDLTRVRCKGFFAQRI..EGA....VVMSLEHVGRCDDLVWS..YPRDVQDRYYPFMDVLHTDMDIRRIGYGEKELITAL.EDPVLA.GLPMHERLLLAMVLRRDAVLYTVSPRLRA..RE..DLP..VHHI........DLPSTSD-........FPD...GLEQLYQESLVLRVGEKD-l..........
#=GC seq_cons                       ...............saIDAuLFMGMHSsD-slRhusKuFFspRL..sss....VhMShEQVGRCDDlVWs..asRclQDsYYPFMDsLHT-MsIcRhGYspsDlptAh.ssssLs.sLPs+-RLLlA.Vls+suhLaTssPRLhu..ts..sLP..Vts.........ssssspss........FPp....LEpLYppSLsLplsspp.h..........
//