#=GF ID   DUF6209
#=GF AC   PF19714.3
#=GF DE   Family of unknown function (DUF6209)
#=GF AU   Williams LS;0000-0001-5551-8526
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Fragoso S;0000-0001-7018-3891
#=GF SE   Manual
#=GF GA   27.50 27.50;
#=GF TC   29.90 30.30;
#=GF NC   27.40 27.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   29910943
#=GF RT   Self-resistance guided genome mining uncovers new topoisomerase
#=GF RT   inhibitors from myxobacteria.
#=GF RA   Panter F, Krug D, Baumann S, Muller R;
#=GF RL   Chem Sci. 2018;9:4898-4908.
#=GF DR   INTERPRO; IPR046181;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents a member of a biosynthetic gene cluster
#=GF CC   (BGC). This BGC (BGC00001940) is described by MIBiG as an
#=GF CC   example of the following biosynthetic class, polyketide. It
#=GF CC   includes a member from the pyxidicycline A biosynthetic gene
#=GF CC   cluster from Pyxidicoccus  fallax [1]. This family appears to be
#=GF CC   predominantly found in  bacteria.
#=GF SQ   45
#=GS W0RIW2_9BACT/5-119        AC W0RIW2.1
#=GS A0A7W7I104_9ACTN/26-145   AC A0A7W7I104.1
#=GS A0A4U1JG43_9DELT/1-109    AC A0A4U1JG43.1
#=GS A0A0G3A7N7_9DELT/16-137   AC A0A0G3A7N7.1
#=GS A0A848LFJ6_9DELT/32-266   AC A0A848LFJ6.1
#=GS A0A848LWY5_9DELT/26-146   AC A0A848LWY5.1
#=GS A0A1M6YA42_9PROT/1-131    AC A0A1M6YA42.1
#=GS K9X5N9_9NOST/26-155       AC K9X5N9.1
#=GS G8SHK5_ACTS5/31-269       AC G8SHK5.1
#=GS A0A0F6YMQ7_9DELT/27-255   AC A0A0F6YMQ7.1
#=GS A0A848LK70_9DELT/22-258   AC A0A848LK70.1
#=GS A0A848LJU3_9DELT/3-136    AC A0A848LJU3.1
#=GS A0A1H8WZY3_9PROT/5-133    AC A0A1H8WZY3.1
#=GS A0A1I1ZR61_9DELT/39-270   AC A0A1I1ZR61.1
#=GS A0A0K1PQW2_9DELT/34-192   AC A0A0K1PQW2.1
#=GS H1YE15_9SPHI/1-127        AC H1YE15.1
#=GS Q1CXY7_MYXXD/26-163       AC Q1CXY7.1
#=GS A0A848LPE0_9DELT/22-257   AC A0A848LPE0.1
#=GS A0A4V2G7X1_9ACTN/48-167   AC A0A4V2G7X1.1
#=GS A0A4U1HEJ0_9DELT/1-109    AC A0A4U1HEJ0.1
#=GS Q1D224_MYXXD/87-316       AC Q1D224.1
#=GS A0A848LIR2_9DELT/34-163   AC A0A848LIR2.1
#=GS A0A7Y6UH15_9DELT/184-297  AC A0A7Y6UH15.1
#=GS Q1D267_MYXXD/36-269       AC Q1D267.1
#=GS A0A848LSF6_9DELT/99-317   AC A0A848LSF6.1
#=GS A0A7W5AQB1_9ACTN/27-145   AC A0A7W5AQB1.1
#=GS A9GLK0_SORC5/1-131        AC A9GLK0.1
#=GS A0A0K1ELL1_CHOCO/25-256   AC A0A0K1ELL1.1
#=GS Q1DG86_MYXXD/30-146       AC Q1DG86.1
#=GS A0A1Z4KYL7_NOSLI/3-137    AC A0A1Z4KYL7.1
#=GS A0A5E6MEA3_9BACT/6-137    AC A0A5E6MEA3.1
#=GS A0A239F665_9ACTN/41-160   AC A0A239F665.1
#=GS A0A7Y6PKC2_9DELT/162-278  AC A0A7Y6PKC2.1
#=GS A0A1H7IMM6_9PROT/1-131    AC A0A1H7IMM6.1
#=GS G8S3Q5_ACTS5/37-265       AC G8S3Q5.1
#=GS A0A1I2FZA9_9ACTN/38-271   AC A0A1I2FZA9.1
#=GS Q1D5B6_MYXXD/123-358      AC Q1D5B6.1
#=GS A0A7W7H170_9ACTN/41-274   AC A0A7W7H170.1
#=GS A0A561VIH6_ACTTI/37-277   AC A0A561VIH6.1
#=GS A0A848LVW5_9DELT/23-253   AC A0A848LVW5.1
#=GS A0A7W7H0M1_9ACTN/37-275   AC A0A7W7H0M1.1
#=GS A0A0K1Q4S3_9DELT/49-290   AC A0A0K1Q4S3.1
#=GS A0A0A6UHY0_ACTUT/50-283   AC A0A0A6UHY0.1
#=GS A0A7H1MYB8_9PROT/3-136    AC A0A7H1MYB8.1
#=GS A0A0F6YMQ7_9DELT/213-267  AC A0A0F6YMQ7.1
W0RIW2_9BACT/5-119                   ...................npt----------...-------.-----------------------------.----------------------...-----------------------------------..--.-------------VPDAAV.....LAF..LDGWRELQHGDITAGGSLVVRYEPSRF.R---.A.-----SAKEIVGYARFlP..GGQIRHATL......R..ERRAPR.T.T...AV..........AAEI.A..VPPETDQVELWFQC.......VD...ADGETVWDSRFGENYRFEV-v.......................................
A0A7W7I104_9ACTN/26-145              .....................a-TTPVIHFSS...DWNTTVE.GVVAANAPVLVEYDPARLPNCRAQYAGGD.AWSIGVEFRIDGGAVQRRPVTQ...LDANRRQVPVPASLPLGAD-ARELELWFVSGDRAG..CR.EYDSRYGANYRFAVAQ---.....---..---------------------------.----.-.----------------.-..---------......-..------.-.-...--..........----.-..--------------.......--...--------------------........................................
A0A4U1JG43_9DELT/1-109               .....................m----------...-------.-----------------------------.----------------------...-----------------------------------..--.-----------------AT.....VKF..SADWTHQQSGDIRSGEALQIDYATERV.CHCR.A.TRYGQKAWSISANVRF.H.pSGQEQAADV......S..SG--A-.-.-...--..........-CQV.N..VPANTSRLEIWFHN.......TD...HTGCSAWDSRYGQNYGFDVK........................................
A0A0G3A7N7_9DELT/16-137              ..................tsaa----------...-------.-----------------------------.----------------------...-----------------------------------..--.--------------AQTPV.....ISF..PVSGPYTVTGTLRAGQPLTVQYALDRL.KTCR.A.TYSGMDTWFITVEYRF.D..YGTFQSAYV......T..TQSTYR.R.E...PV..........PATI.T..APVGARTLEMRFKN.......WD...RGSCVAYDPSSWPIYTFTL-q.......................................
A0A848LFJ6_9DELT/32-266              .....................t-PPPTMTFGP...NWSVSLS.GQPRVGGPLRIVYDLSRLSHCREP--SVG.TWTLTGYAMTNRGPVQSFVVA-...---NDATVGTTAEVLLNLTTGGNLELWFQETHSLG..CS.NWDSNLYWNHHVKVWQNPT.....LTF..NEGWTHSLFGTLQGGTTLMVDYDIDRL.GQCR.G.QYMDYETWGVWVEYRI.N..GGPVQTHDL......T..VAWGEW.N.Q...EFrk......qtPAFI.P..LPAGPGTLEMWFVN.......MD...RKGCAAYDSRYGQNYVFT--fq......................................
A0A848LWY5_9DELT/26-146              .stspsitfkspsqgwgvvass----------...-------.NPLPYGKTASIIYSVDRLTACRGNINSTTpGWTITGYYQFNNGPVQYFWVAG...FSSVPNPPAP----SIPLNQKGTLAVWFENTNRWG..CQ.AWDSNYGNNYVFNVQ----.....---..---------------------------.----.-.----------------.-..---------......-..------.-.-...--..........----.-..--------------.......--...--------------------........................................
A0A1M6YA42_9PROT/1-131               ....................mk----------...-------.-----------------------------.----------------------...-----------------------------------..--.---------------SKAT.....IQF..LGDWREFQHGMIERSGRLKVEYDMHRL.PHCF.T.TWHGAGLGDITAYIRF.H.pRGEVVSGSV......I..APVRNQ.E.S...PPgiii.ghvpaPFET.A..VPDDAAQAEIWFHN.......FYq.tSTRCDAWDSRFGSNYWFEI-d.......................................
K9X5N9_9NOST/26-155                  ................spsyav----------...-------.-----------------------------.----------------------...-----------------------------------..--.--------------S-SAE.....IDF..TKDWQENVTGQLAPSGQLKIIYDESRL.TCRR.T.NYRGIPSWQILAGFQFeD..NGQVQYKSL......R..KKQDNF.L.-...-T..........PLEI.D..IPSNAQKLNIWFENygydpydTS..eQNDIRCYDSDYGNNYNFQL-s.......................................
G8SHK5_ACTS5/31-269                  .....................s-PAPVLHFNA...DGSTAVD.GVIESGHPVTVDFDPARLPRCRGTDEYGD.SWGISVQYRIDGGDLRVYPVTQrvtADGKDTTVRSLGTLQLRPD-THQLQMWFVAEDRTG..CH.EEDTAGGANYRFDINQPPVl..arAAY..NADWSETVTGPLRRGGALVLNYDPARL.PQCR.A.TYRGYPAWEIDVYYRF.D..GGPVQSTPV......N..QA-AEA.I.-...--..........PVRI.D..IPANARKIETWFKN.......SD..pYTQCSAYDSDYGRNYTFPI-g.......................................
A0A0F6YMQ7_9DELT/27-255              ....................gr--SAELVFTA...DHQQRVE.GTLVAGGIATISYDASRLTTCRGE-RYGNpAWSIYAHYRIAGGDVRSVHVAG...HAPAPDQV----GLPIELTQAGELEVWFENTSSFG..CQ.GWDSAFGANHRFTIEAAQTdeapiARF..AAGGGISVSGDVRQSARLTIEYDVARL.PQCR.D.TRYGLPAWSVLAHYRF.P..SGRTGYVPV......T..SG----.-.-...--..........SATL.D..LV-ESGELQLWFEN.......QG...YYGCRAWDSLDGANYRV---vvd.....................................
A0A848LK70_9DELT/22-258              ...................tsi---PTITFNDgsaGWSIVQS.APLVPGGQVKIIYDTDRLPGCRGTINGNP.AWSVTGSYQLNDGTVGSFYAG-...GGANYPGQSPEAVLDLPEN--GSLALWFHISNRWG..CR.EWDSNYGNNFRFDVGG-PR.....IVF..GADWTTAVYGTLKQGGTVTVDYDITRL.SGCR.Q.TYNGLQTWDVEAQYRF.D..GGTVQTAPL......T..QVVGMSgR.E...QV..........PAVI.T..APASASLLELWFRN.......WD...RTSCQTWDSAYGQNYRFTL-v.......................................
A0A848LJU3_9DELT/3-136               ..................srhg----------...-------.-----------------------------.----------------------...-----------------------------------..--.-------------LGKPAA.....LYF..THTWNQRLEGDLTPGGKLSIYYDPHRM.PLAR.D.YLFGAPAQPITAHVKFsE..QGPVQDKVL......W..SPAGIL.R.H...VDkdplgygsmlFQEL.V..IPPDAEEVIVWFDY.......RS...SDGQVHYDSDYGRNYAFR--fl......................................
A0A1H8WZY3_9PROT/5-133               ...............ststvqt----------...-------.-----------------------------.----------------------...-----------------------------------..--.------------------A.....LRF..LPEWLESRDGPIVRGRNLSIAFDPTRL.TGCR.R.NWRGTDVWEIEGVVKF.HprGDVVRGTLL......EpiRTSGVV.T.G...HS..........PKAL.EvtVPSDATQIEVWFHN.......FAe.vGGRCDAWDSRFGQNYWFDVE........................................
A0A1I1ZR61_9DELT/39-270              .....................i-QPALLEFRD...DWTIVNSgGPLVAGNTVQVGYDVDRLTDCRGD-QNGKpAWSITGYHQLDGGDVGSFEAGG...YSPSQGTEPPI----FTLEDSGDLTMWFHNTSVWG..CS.AYDSNYGANWHFGVG--AS.....LSF..KADWVTEVLGTPRAGAPLVIAFDPARL.PDCR.A.TKYGHDAWNIRVHYRF.D..GGPAKYALV......T..APQGNI.Q.V...PW..........PAVI.D..VPAGAGEVELWFEN.......QD...YYGCKAWDSQFGANYHFDL-e.......................................
A0A0K1PQW2_9DELT/34-192              ....................ge--AGTITFSA...NGDVRVQ.GTLERGKTARVAYDADRLTTCRGE-QGGLpAWTISGYYRIAGGVIRSFEAGG...LSPSHGTDKPV----LTLDSAGDLEVWFQNTSRWG..CN.AYDSDFGRNFHFSVNPAA-.....---..---------------------------.----.-.----------------.-..---------......-..------.-.-...--..........----.-..--------------.......--...--------------------sdpgwignlravvsrmtcdggkacesdmdepengevrydt
H1YE15_9SPHI/1-127                   .................mshli----------...-------.-----------------------------.----------------------...-----------------------------------..--.-------------------.....--F..TLDFHEIVRGKLKKGQQCTINYDPLRL.ATSK.EgFVHGSPDFEFTAYVLF.K..PTGQQTVKL......S..SDTGIV.P.D...AVpqrngqgamlTGNF.E..IPENAEEIITWISM.......KD...NHGEYFYDSDFGKNFHFRL-e.......................................
Q1CXY7_MYXXD/26-163                  ...qeetsanamelqqapltap----------...-------.-----------------------------.----------------------...-----------------------------------..--.----------------TAT.....VRF..LNGWTHSQHGAIVRGGTLVVDYDLYRM.TDCHhS.TYAGQQAWDTLAYVRFlP..SGQLFSGSV......K..QATGST.SfV...NK..........PFEV.T..VPSDATSVETWFFT.......SG...RTCAPKYDSNYGQNYVFPVE........................................
A0A848LPE0_9DELT/22-257              .....................q-TAPVISFNA...NWSLTES.APLVAGGSAQVAYDATRLPQCRTWLADGTpTWSITGHYRLNNGTPGSFDVAG...LPST---GAAP-V--IPLPEAGSLEVWFRVS-GPD..CE.HYDSNYGTNFRFTVQPAGTavpptIVF..QEGWVEYVVGTPKAGQPLVIDYDIDRL.PECR.L.LYNGAPTWDVAVHYRF.G..SGTVTTTSV......T..TVSGFS.R.R...GA..........PVTI.Q..APTWARSVTMWFEN.......WD...RGYCRRWDSQFGANYTFTIQ........................................
A0A4V2G7X1_9ACTN/48-167              .....................v-TAPLVRFLP...DWITTVE.GAIVANSTVLVDYDPARLPTCRAQYAGGD.AWSINVEYRVDGGTVQRQPVTQ...LDSNRKQAKVLASVPLAAD-AHEVELWFVSGDRAG..CR.EYDSRYGANYRFPVA----.....---..---------------------------.----.-.----------------.-..---------......-..------.-.-...--..........----.-..--------------.......--...--------------------r.......................................
A0A4U1HEJ0_9DELT/1-109               .....................m----------...-------.-----------------------------.----------------------...-----------------------------------..--.-----------------AT.....VSF..SSDWSQQQSGDVRAGESLRIEYATERL.CTCR.A.TRYGQKAWGLTANFRF.H..PSR-QEQSL......D..VSSGAC.E.-...--..........---V.N..VPADASRIEVWFHN.......TD...NTGCSAWDSRYGQNYSLDVK........................................
Q1D224_MYXXD/87-316                  .....................t-TPTSITFDG...DWNETPSvELIPVGGQVVVNYDISRLPQCRGTTSSGNpTWTITGHVQVNRGPVVSFWVAG...--HAPDGNSSQRVLHLPAGLSGALVMWFDIS-SQG..CQ.AWDSNHGSNYHFAIG-APT.....LSF..NANWDEVIAGTLRAGQQLIVNYDEARL.PECR.A.TYNG-PAWSIVAQYRF.D..NGPIQETVV......T..GS-GRS.E.-...--..........PTAI.T..APAGARHLEMWFRN.......TD...RSSCVSYDSNYGSNYHFAVE........................................
A0A848LIR2_9DELT/34-163              ............esqqaslttp----------...-------.-----------------------------.----------------------...-----------------------------------..--.----------------TAT.....VRF..LGGWSQEQRGAIVRGGQLVVDYELYRM.TDCH.NsTYAGQQAWDTLAYVRF.Q.pGGQLFSGSV......K..QATGST.T.F...VN.........kPFVVpT..VPADATSVELWFFT.......SG...RTCQSRYDSNYGQNYRFPVE........................................
A0A7Y6UH15_9DELT/184-297             ..................pagp----------...-------.-----------------------------.----------------------...-----------------------------------..--.---------------QRAR.....LVF..DANWTHHREGVLAPGGQVSISYAQTRL.DGCR.Y.TQGPYQLWDITAHVRF.E..PGNQLLAG-......S..VRDGVW.T.-...--..........---L.S..VPSDAQRAVVWFES.......TS...ASGCHQWDSNYGDNYVFD--aa......................................
Q1D267_MYXXD/36-269                  ....................sg--PPTLTFAA...DWSVTLS.GQPEAGGALDIAYDTSRLPLCRGT-----.GWTITGFAMSNRGPVQGFPVA-...---DATTVGAIAQTQLALAQGGTLELWFQNTDATG..CS.HWDSNLQYNFHTWVTQNPT.....ISFhpAPAWTYTVHGTLQGGTTLMVDYDLGRI.AQCR.A.QYLNYKAWGTTAHYRI.N..GGPVTMLSL......T..ASWGEW.D.A...EFwr......qiPAFI.P..LPPGPATLELWFSS.......QD...RKGCQQWDSRHGQNYVFAIQ........................................
A0A848LSF6_9DELT/99-317              ...............grgpsfh----------...-------.--AEAGKPLTVTVDPQRISQSAQK-----.--AELVWYVVPGGKEVAVPLTDg.sRGADGKLNMLPAKIDVPENAFGTLRLSIRTTSADGreSS.SWDPSSDAAI--APPEGAT.....VVF..SDNWQTQMEGKLRAGDKVQIAYDRDRL.SELL.-.--GGKTPSDVVACVSF.N..GEPPIEVPL......T..VQPGEG.G.EpgkMF..........MPSL.K..VPLEATQMTMWFKG.......QG...-EGATGWDSSFGQNFKFKV-s.......................................
A0A7W5AQB1_9ACTN/27-145              ....................ga--TPVLHFVA...DGTEWTE.GALEAGRPVLVDYDLARLSRCRSQYAGGD.AWSIGVHYRVDGGPIQRQAVTR...LDETRHNVKAPASIDLPIG-GKDLELWFQAGDRVG..CT.EYDSQYGANYHYTI-----.....---..---------------------------.----.-.----------------.-..---------......-..------.-.-...--..........----.-..--------------.......--...--------------------s.......................................
A9GLK0_SORC5/1-131                   ...................mat----------...-------.-----------------------------.----------------------...-----------------------------------..--.----------------TAV.....LQF..LPDWQHAQQGPIERGGKLRIEYELSRL.SRCF.T.TWRGAEIGDITAYVRF.HprGAIVQGSVVeevrapG..NPPGHV.V.A...HK..........PAAL.EisVPDDATQAEIWFHG.......FSq.tSRRCEAWDTRFGDNYWFDV-g.......................................
A0A0K1ELL1_CHOCO/25-256              .....................s-TQPTLTFHD...DWTVEQE.GQPSTDTPLRIRYDLDRLAQCRGP-----.SWTITGYMMSNRGPVSSFTVA-...---SPWTTGPTAELNLAVSRGGNLELWFQVTDANG..CS.AWDSDHNWNFHTWVTHDPT.....VTF..SADWSETLTGTLQAGSTLMVDYDIGRL.PLCR.A.YYLNYVAWSVSLNYRF.D..GGEIFTAPL......T..TTWGEW.N.L...QYwr......qiPAFI.N..IPPGVSQVEMWFSN.......TD...RKACQEYDSDYGQNYIYQVQ........................................
Q1DG86_MYXXD/30-146                  sitfqspaqgwnvfassnplpf----------...-------.-----GSTAAIHYSVDRLTQCRGNINGTTpGWTMTGYYQFNDGPVQRFWVAG...FSSTPNPPAPS----IPLNTRGTLAIWFENTSRWG..CQ.AWDSNFGNNHVFTVQ----.....---..---------------------------.----.-.----------------.-..---------......-..------.-.-...--..........----.-..--------------.......--...--------------------........................................
A0A1Z4KYL7_NOSLI/3-137               ....................sg----------...-------.-----------------------------.----------------------...-----------------------------------..--.-----------FGLGKPAQ.....ITF..TLDYHELITGDLKPNVNCHISYDPLRIvPQDG.T.YVHGDPNQPIFVHVQFqE..NGPTESKKL......Y..SPNGII.S.D...PHinvagqgsmlFQEV.F..IPSDAKKLIIWFSY.......LD..pNTNETLYDSDFDRHFHF---rw......................................
A0A5E6MEA3_9BACT/6-137               ..................fanl----------...-------.-----------------------------.----------------------...-----------------------------------..--.----------------PPR.....ITF..TADFHELVRGNLQPGQTVTLRYDPRRIvPAGE.H.YVFGDPTHRITAHLLF.P.pTGVVAAALL......S..SPSGML.N.S...PDydetgdgsvlVGHV.V..IPAGARELVAWFEY.......ES...PHGAKHYDSDFGHNFHFG--fa......................................
A0A239F665_9ACTN/41-160              .....................t-TAPLIQFAP...DWTTTVE.GVITANGTVVVDYDPARLPTCRARYAGGD.AWSINVEYRIDGGPLQRQPVTQ...LNSDRRQVKVPASLPVPAE-ARELELWFVSGDRTG..CR.EYDSQYGANYRFPVA----.....---..---------------------------.----.-.----------------.-..---------......-..------.-.-...--..........----.-..--------------.......--...--------------------g.......................................
A0A7Y6PKC2_9DELT/162-278             ....................na--GAVLAFES...DWSETQD.RALHAGDQVIVHYDPARLAQCAASTHGGA.AWNITMSYQADGGPINSLVVGR...MNGSELVA---ADSSFTVPRGNDLAVWFHATSVYG..CN.QYDSNMNANYHFAIE----.....---..---------------------------.----.-.----------------.-..---------......-..------.-.-...--..........----.-..--------------.......--...--------------------........................................
A0A1H7IMM6_9PROT/1-131               ....................mk----------...-------.-----------------------------.----------------------...-----------------------------------..--.---------------SKAV.....IQF..LRDWRELQHGAIERNGRVKVEYDMQRL.PKCF.T.AWRGAEFGDITAYIRF.H.pRGEIIRGSV......V..APVREQ.E.I...QPgmvi.ghvpaPFET.G..VPDDATQAEIWFHN.......FYq.tSARCDAWDSRFGRNYWFDI-g.......................................
G8S3Q5_ACTS5/37-265                  .....................t-AAPVIHFAA...DGTDRVD.GAIEAGRPVIVDYDLSRLPECRNQYAGGD.AWSIGVYYRVDGGPIQTRPVTR...LDQNRHNVTAPAGIDLPPG-GHDLELWFHAGDRAG..CS.EYDSRSGANYHYPIGQPAV.....VTF..RADWSETVTGSIEAGHRLALRYDTARL.PECR.D.Q-----AWRIDVFRRF.D..GGPAQSETL......T..TGDGSQ.V.-...--..........PGSI.D..IPAGSHQVEIWFQV.......TA..dQGGCTAYDSDFGANYVYAV-a.......................................
A0A1I2FZA9_9ACTN/38-271              .....................e-PGPVLHFAA...DGSERVD.GVLEAGRPVLVDFDLERLPKCRSRYAGGD.AWSIGVHYRVDGGPISVQQVTR...LDENRHNVKAPARIDLPLG-AHDLELWFHAGDRAG..CS.EYDSRYGANYHYAIEQPPV.....VTF..RADWSETVSGPIRAGRGLVVRYDPARL.PQCR.E.TYDGVPAWRIDVFSRF.D..GGPAQSQAV......T..GPDGES.V.-...--..........PTIV.D..IAPGTGRVELWFRV.......TG..rHSGCTAYDSDFGANYPYPV-s.......................................
Q1D5B6_MYXXD/123-358                 .....................q-TTPTLTFHG...NWTIHQS.EVLTEGGQVQVVYSTARLPQCRVNNPDGSpAWSITGHYRINGSAPASFDVA-...--GAPVTGNGP-TLDLQEQ--GLLELWFLVS-SPG..CE.HYDSNYGGNFQFNVLEASAt..pmATLvfQQGWVEHVVGTPRQGQPFIVDYDIARL.PECR.L.LYNGAPTWDVGVRWRF.N..NGVMGEKSV......T..TTSGYT.R.T...GT..........PVTI.I..PPVGATSVQIWFEN.......WD...RGTCRRWDSDYGANYTFTL-q.......................................
A0A7W7H170_9ACTN/41-274              ....................ag--TPVLRFAA...DGTDRVD.GTLEAGRSVLVDYDLARLAQCRNQYAGGD.AWAIGVYYRIDGGPIATQPVSR...LDENRHNVKAPVPIDLPLG-AHDLELWFHAGDRAG..CS.EYDSRSGANYHYAIEQPAV.....ATF..RADWSESVSGPIRAGHGLAIRYDLARL.PQCR.E.TYNGMPAWRIDVHYRF.D..GGPVQSQAL......T..GSSGEP.V.-...--..........PATV.D..VAPGSRRIELWFQV.......TG..qRSGCTAYDSDFGANYAYAV-a.......................................
A0A561VIH6_ACTTI/37-277              ....................tg--APVLHFHA...DGSTSVE.GVIESGRPVQIDFDPARLSKCRGTDEYGD.SWGISVQYRIDGGQVRVYPVTArvtADGTDTTVRSLGILQLRPD-TRHLQMWFVGEDRTG..CH.EEDTDHGANYQFDINQPPVl..arATY..QADWSETLTGSLRQGGALVIDYDPARL.PQCR.T.TYRGYPAWQIDAFYRF.D..GGPVRSTPV......N..QG-AEA.I.-...--..........PIRI.D..VPANAQQIETWFTI.......GVpypPTGCSAYDSDYGKNYTFSI-d.......................................
A0A848LVW5_9DELT/23-253              ..................tttp---VAITFDG...NWNETPSvEVIPAGGQVVVNYDISRLPQCRGTTSSGSpTWTINGYVQVNRGPVVSFWVAG...LSPDNQNQR---TLHLPAGVSGALVMWFDIS-GPG..CQqAWDSNYGSNYHFAIGGP-A.....LSF..NSNWDEVVTGTLRAGQQFIINYDVNRL.PECR.A.TYNG-PAWVISALYRF.D..NGPIQETVV......T..GS-GYS.V.-...--..........ATPI.V..APAGARHLEMWFRN.......TD...RSSCVRYDNNYGANYHFYL-q.......................................
A0A7W7H0M1_9ACTN/37-275              ....................tg--TPVLHFNA...DGSTSVD.GVIESGHAVTIDFDPARLPHCRGTDEYGD.SWGISVQYRIDGGDLRVYPVTErvtADGKDTTVRSLGTVQLRPD-TQHLQMWFVNQDRTG..CH.EEDTNHGANYEFDISQPPVl..arATY..RADWSETLTGSLRKGGALVIDYDPARL.PQCR.A.TYRGYPAWDITAFYRF.D..GGSVRSAVV......N..QG--DE.V.-...-I..........PFRI.D..VPADAQKIETWFKI.......AN..yYAQCSAYDSDYGKNYTFAI-n.......................................
A0A0K1Q4S3_9DELT/49-290              ......................TDAAKVKFLS...DFTTVVT.GTPKAGKRLRVEYALDRLPQCRGEVGGGGpAWNITGFYSENGAPAKTFEVTKlssDGHDRVAKSAL----LPISSGGDVAIWFQVTSSFG..CS.EYDSQYGQNYHFAVTGRAPevaarLVF..KESGEVEQQGELHAGDKIAVYYEQGRL.PQCH.R.VERGAPVWTVSGFSQF.E..GGAVKAFET......G..RANGSD.R.E...TI..........DAIL.E..LPQRTGQIVFWFEV.......NS...IDGCMHLDGNGGMNYAFDVK........................................
A0A0A6UHY0_ACTUT/50-283              .....................t-PTTTLRFAA...DGTDRLD.GILEANRSVLVHYDPARLPACRNQYAGGD.AWSIGVYYRIDGGPIRTEPVTR...LDETRHNVAVPVRVDLPLG-GRDLEMWFHAGDRTG..CS.EYDSRSGANYHYTIEQPAV.....ATF..GADWSESVTGPIRAGHGLVVAYDPARL.PQCR.E.TYNGAPAWHIDVLHRL.D..GGPVQSRTL......T..GSDGRA.V.-...--..........PVTL.D..VTPGSGRVEMWFRV.......TG..qRSGCTAYDSDFGANYAYAV-a.......................................
A0A7H1MYB8_9PROT/3-136               ...............qrrakgl----------...-------.-----------------------------.----------------------...-----------------------------------..--.----------------PAR.....ITF..SRDFHELLTGDLCRGQPLHIAYDPRRIvPADA.A.VRCGEPDRPVTLHARFyA..SGPEMTLPL......V..SPAGIV.V.A...PVedatrraclvTGTL.T..VPADANGVSLWFSY.......PA...ADG-ERQDNDYGATFRFR--fp......................................
A0A0F6YMQ7_9DELT/213-267             ..................tsgs----------...-------.-----------------------------.----------------------...-----------ATLDL--VESGELQLWFENQGYYG..CR.AWDSLDGANYRVVVDADPR.....A--..---------------------------.----.-.----------------.-..---------......-..------.-.-...--..........----.-..--------------.......--...--------------------pgwmgna.................................
#=GC seq_cons                        .....................s..........................st.h.l.hs.tRls.st..........s..h.h..stu......hs...................h.....ttl.hWF..t...G..Cp.t.Dot.t.Na.h.lt.sss.....lpF..ttsWpp.hpGslptGttlhlpYD.tRL.spC+.t.hh.G..saplsshhRF.p..sG.htttsl......s..ts.u.....................sh.l.s..lPssupplphWFps........s...tsssptaDSpaGtNYhFtl.........................................
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