#=GF ID   DUF6211
#=GF AC   PF19716.3
#=GF DE   Family of unknown function (DUF6211)
#=GF AU   Williams LS;0000-0001-5551-8526
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Fragoso S;0000-0001-7018-3891
#=GF SE   Manual
#=GF GA   25.00 25.00;
#=GF TC   25.30 30.40;
#=GF NC   24.10 21.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   16766657
#=GF RT   Amplification of the entire kanamycin biosynthetic gene cluster
#=GF RT   during empirical  strain improvement of Streptomyces
#=GF RT   kanamyceticus.
#=GF RA   Yanai K, Murakami T, Bibb M;
#=GF RL   Proc Natl Acad Sci U S A. 2006;103:9661-9666.
#=GF DR   INTERPRO; IPR046183;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents a member of a biosynthetic gene cluster
#=GF CC   (BGC). This BGC (BGC0000703) is described by MIBiG as an example
#=GF CC   of the following biosynthetic class, saccharide. It includes a
#=GF CC   member from the kanamycin biosynthetic gene cluster from
#=GF CC   Streptomyces  kanamyceticus [1]. 
#=GF SQ   12
#=GS A0A345HQR3_9ACTN/1-95  AC A0A345HQR3.1
#=GS A0A1G9F3U3_9ACTN/1-92  AC A0A1G9F3U3.1
#=GS A0A7X6CWW4_9ACTN/1-92  AC A0A7X6CWW4.1
#=GS A0A1V4A2Z2_9ACTN/1-92  AC A0A1V4A2Z2.1
#=GS A0A1E5NXH5_9ACTN/2-95  AC A0A1E5NXH5.1
#=GS A0A4R7MAC4_9ACTN/1-92  AC A0A4R7MAC4.1
#=GS A0A101TWV8_9ACTN/1-92  AC A0A101TWV8.1
#=GS A0A291W4J8_9ACTN/1-92  AC A0A291W4J8.1
#=GS A0A6B2RPM7_9ACTN/1-60  AC A0A6B2RPM7.1
#=GS A0A6I6SCW5_9ACTN/1-92  AC A0A6I6SCW5.1
#=GS A0A7H8NAV5_9ACTN/1-92  AC A0A7H8NAV5.1
#=GS A0A1Q5LK81_9ACTN/1-92  AC A0A1Q5LK81.1
A0A345HQR3_9ACTN/1-95             ............MLCDHHPD.APRPGDLARLRPGNSIGAD---TFVIVEDF..PPSGAsgpnggHVVLNRPDGRRGHEDWAAAVTVDQISALTRIEPDGSRTWGPAPHPEDIR.....
A0A1G9F3U3_9ACTN/1-92             ............MLCDRHPD.CPQPGDIAQLTRGNSIGADPGDSFVIVEDF..PPTGP......HLVLNLPVDHPGRADWAAAVPLADIASLTRLEPAGSRTWVPAPDPDDIQ.....
A0A7X6CWW4_9ACTN/1-92             ............MLCDRHPD.HPQPGDITQLKPGNSIGAAPSDSFVIVEDF..PPSGR......HLVLNLPAGHPRQEDWAAAIALADIATLTRLEPAGSRTWTPIRDPDD--ap...
A0A1V4A2Z2_9ACTN/1-92             ............MLCDRHPD.CPQPGDIAQLTRGNSIGADPGDNFVIVEDF..PPTGR......HLVLNLPVDHPGRADWAAAVPLADIATLTRLEPAGSRTWTPAPEPDDI-l....
A0A1E5NXH5_9ACTN/2-95             ..........mv--NDAEMDtAPALDDWITLNVVNSAGADASDTYRI-EDG..PLPGDg....gWFIVLADENSPGAKDWATAIKDTDIKRITRPIESGVMQWDYQPQ-----etmae
A0A4R7MAC4_9ACTN/1-92             mledqntpldds--------.GPLPYDTITLHPGNSAGAPAAEVYVLADFApaPAGGQ......AWEINHPDSHPRYWDWAATVTTSDIALITRMTPAGPVSWAP--------ir...
A0A101TWV8_9ACTN/1-92             ............MLCERHPD.CPQPGDIAQLKGGNSIGASPKQCFILVEDF..PPTGR......HLVLNLPAHHPSRADWAAAVPLDDIATLTRIEPDGSRTWTPAPEPGD--st...
A0A291W4J8_9ACTN/1-92             ............MLSDQHPD.RPRPGDFAKLKAGNSIAADPGATFVIVEDS..PSGLE......HVVLNLPAGQPRHEDWAAVIDLDEIASLTRVSPEGARTWTPDPDPEAR-a....
A0A6B2RPM7_9ACTN/1-60             ...........m--------.-------------------------VVEDF..PPTGR......HVVLNLPTGHLGRADWAAAVPLADIATLTRLDKAGSRTWAPAPDPDDTQ.....
A0A6I6SCW5_9ACTN/1-92             ............MLCDRHPD.CPQPGDIAQLTRGNSIGADPGDSFVIVEDF..PPTGR......HLVLNLPVDHPGRADWAAAVPLADIATLTRLEPAGSRTWAPAPDPDDIQ.....
A0A7H8NAV5_9ACTN/1-92             ............MLCDRHPD.SPQPGDIAQLTGGNSIGANPNDTFVIVEDF..PPTGR......HLVLNLPVDHPGRADWAAAVPLADIATLTRLEPAGSRTWAPAPDPDDIR.....
A0A1Q5LK81_9ACTN/1-92             ............MLCDRHPD.CPQPGDIAQLTRGNSIGADPTDTFVIVEDF..PPTGR......HLVLNLPVDHPDRADWAAAVPLADIATLTRLEPAGSRTWTPAPDPDDIQ.....
#=GC seq_cons                     ............MLCD+HPD.sPpPGDlApLphGNSIGAsPs-oFVIVEDF..PPoGc......HlVLNLPssHPu+tDWAAAVsLuDIAoLTRlEPAGSRTWsPAP-P-Dh......
//