#=GF ID   DUF6245
#=GF AC   PF19758.3
#=GF DE   Family of unknown function (DUF6245)
#=GF AU   Williams LS;0000-0001-5551-8526
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Fragoso S;0000-0001-7018-3891
#=GF SE   Manual
#=GF GA   25.00 25.00;
#=GF TC   25.10 29.60;
#=GF NC   24.80 24.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   19362651
#=GF RT   Enzymology of aminoglycoside biosynthesis-deduction from gene
#=GF RT   clusters.
#=GF RA   Wehmeier UF, Piepersberg W;
#=GF RL   Methods Enzymol. 2009;459:459-491.
#=GF DR   INTERPRO; IPR046212;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents a member of a biosynthetic gene cluster
#=GF CC   (BGC). This BGC (BGC0000700) is described by MIBiG as an example
#=GF CC   of the following biosynthetic class, saccharide. It includes a
#=GF CC   member from the istamycin biosynthetic gene cluster from
#=GF CC   Streptomyces  tenjimariensis [1]. 
#=GF SQ   10
#=GS A0A2U2Z358_9ACTN/8-180   AC A0A2U2Z358.1
#=GS A0A402BLB9_9CHLR/22-188  AC A0A402BLB9.1
#=GS A0A285J0H2_9ACTN/11-168  AC A0A285J0H2.1
#=GS A0A171DQB0_9ACTN/1-155   AC A0A171DQB0.1
#=GS A0A7W7S209_9ACTN/20-186  AC A0A7W7S209.1
#=GS A0A839DX05_9PSEU/28-154  AC A0A839DX05.1
#=GS A0A553ZMB1_9ACTN/1-105   AC A0A553ZMB1.1
#=GS A0A1Q9TMH3_9ACTN/19-188  AC A0A1Q9TMH3.1
#=GS A0A1G9ENK7_9ACTN/50-217  AC A0A1G9ENK7.1
#=GS A0A327WF17_9ACTN/1-167   AC A0A327WF17.1
A0A2U2Z358_9ACTN/8-180              .........LAALGTYGGENTPEEHSGEAARLGGADAYRVRVVNALLGVVQTEAALADGVVLDE.......EAHHAAWEQQLTAAGTgldEDPVKRVEFIRWQVLRAGTPLRLMAQSREVGPIPLAAAHAATGPHQLLGVIAASQDAvaTGDVERLAAQSDQLRAAREALENAVNNTDLLLNMLKSVG-p............
A0A402BLB9_9CHLR/22-188             .........MIALGKYTGENSDAERTAEAKRLGGMEAYRLLLANALLGIVETDAMFADSADVSA.......EQMQAAHWQALKAAGA..eEDPGKLLHFLRWRTLRVEGPLREIAQNTEAGPLPLAAAHAAEGLQLLLGICAAGQNL..--EVASPAEMTTNLKGAREALTNAAANIDVMLNLLAQAE-d............
A0A285J0H2_9ACTN/11-168             ...lealga----------------APEGDDLGDTNARRAWLAGALLAAAQAEAMAADRLMMSR.......DARYALWQRQLDGA--...DEPSQRADRIRWQVQRACLPLPAMAHESRTDPIPLAAGQAAEGLELLLSVSAATYGAvaAGDVARLTAQAGRLREARKVLQAAVDNTDDLLEMLGSVD-i............
A0A171DQB0_9ACTN/1-155              ........m-------------AEHEAGSARSGGMVSYRMHLANALLGAVQVEAMLAEIGAAGL.......EELEAAHAQQPATAGV..dGDPERLTAFLRWQASRVAGPLRLLAQGPSTGPIPLAAAHTAEGLQRLLGVIGAGQVP..--SVGAVAAHVAELERARACLVDAIGNVDILLQMLNRL--sa...........
A0A7W7S209_9ACTN/20-186             .........LAALGLYGGTNTAAEHAAEALRLGGPEPYRMQLANALLGAVQVEAMLAESAATRP.......EDLAAAHHQQLATAGV..aDDVEKLAGFLRWQALRVAGPLRLVAQDPATGPIPLAAAHTAEGLQKLLGIAGTGQVP..--DVDAVKEGVAEMRAARQCLVDAIDNVDILLEMLS----glsa.........
A0A839DX05_9PSEU/28-154             dkrtrvrtt------------------------------LSLANALLGTAEREIVRAEMDLGYTslpqdeiDAVVRASERSVDAAAGwaeESAEGQHAVLHWRTTRLHRALAQRLESAETDPALAAACDAAALTAVLLGYCEAR---..----------------------------------------elqfidtehaegw
A0A553ZMB1_9ACTN/1-105              ........m---------------------------------------------------ELDD.......DARHTAWEEQLTATGAgllDDPLARVEFIRWQVLRAGTPLRLMAQNPATGPIPPAAVHAPTGLHMLLGVIAVA---..LGDVDTPAAQAGQHQAAREALS------------------vrltm........
A0A1Q9TMH3_9ACTN/19-188             .........MAALGLYSGDNTTDEHAAEAARLGGQEAYRVRMVNSLLGSAQAQALLAETADITP.......DARNAAYADQVASAGA..dHDPVALVEFLRWQVLRAATPLREMAQDPATGPVPLAAAHAAEAIQVLLGVVSASRTAmaTGDTDTLLAQTNSIDTAKEALENALTNVEMFRSLLA----pir..........
A0A1G9ENK7_9ACTN/50-217             .........LQALGHYRGNNTAAEHAAAAERIGGEAVYRAYLANALLGAAQLEAILNESGEFDA.......EQRTAVYLQQQQTAGV..aGDQTSMLEFLRWQLLRLASPLRENAQSEQAGPVQVAAAQTAEGLDRLLSVSAASQTL..-TDQADIDSVAEQLDTAHQALSSAAENIDQLRALTE----rars.........
A0A327WF17_9ACTN/1-167              .........MTALGVYAQQPDPEELERQAVSVGGEHVLAAVLANALYGASIGTGMVTEGNMLEAga...gsEEMALAREQVFKASGA...-DWTGVIGLLHWQTGHVWNALKTMSEEDHE-PLGTVGAHASNALLNLLSCMSVT---..GADDPRAADVPADLERVRADLVAAVEALDALPVSGTEVS-s............
#=GC seq_cons                       .........h.ALGhYttpssstE+supAtRlGG.psYRhhLANALLGusQsEAhlAEssthss.......EshpAAapQQlsuAGs..t-DPsphlcFLRWQsLRlusPLRthAQsspTGPlPLAAAHAAEGLphLLGVsuAups....sDVsslsutsspLcsARpsLssAlsNlDhLhphLs....sh...........
//