#=GF ID   DUF6256
#=GF AC   PF19770.3
#=GF DE   Family of unknown function (DUF6256)
#=GF AU   Williams LS;0000-0001-5551-8526
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Fragoso S;0000-0001-7018-3891
#=GF SE   Manual
#=GF GA   25.00 25.00;
#=GF TC   32.10 30.60;
#=GF NC   24.90 22.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   26091168
#=GF RT   Iterative Mechanism of Macrodiolide Formation in the Anticancer
#=GF RT   Compound Conglobatin.
#=GF RA   Zhou Y, Murphy AC, Samborskyy M, Prediger P, Dias LC, Leadlay
#=GF RA   PF;
#=GF RL   Chem Biol. 2015;22:745-754.
#=GF DR   INTERPRO; IPR046223;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents a member of a biosynthetic gene cluster
#=GF CC   (BGC). This BGC (BGC0001215) is described by MIBiG as an example
#=GF CC   of the following biosynthetic class, NRP (non-ribosomal
#=GF CC   peptide). It includes a member from the conglobatin biosynthetic
#=GF CC   gene cluster from Streptomyces conglobatus [1]. 
#=GF SQ   15
#=GS A0A2U2ZDW2_9ACTN/2-109    AC A0A2U2ZDW2.1
#=GS A0A345T3M5_9ACTN/105-209  AC A0A345T3M5.1
#=GS A0A3A9Z6Q2_9ACTN/7-115    AC A0A3A9Z6Q2.1
#=GS A0A4R4TFH5_9ACTN/11-121   AC A0A4R4TFH5.1
#=GS A0A367YY37_9ACTN/19-133   AC A0A367YY37.1
#=GS A0A0F7FZS3_9ACTN/11-121   AC A0A0F7FZS3.1
#=GS A0A4R4TBV9_9ACTN/11-120   AC A0A4R4TBV9.1
#=GS A0A7M2SAS8_9ACTN/2-122    AC A0A7M2SAS8.1
#=GS A0A561TV69_9ACTN/24-135   AC A0A561TV69.1
#=GS A0A365YPZ0_9ACTN/11-111   AC A0A365YPZ0.1
#=GS A0A4R4PJQ7_9ACTN/11-124   AC A0A4R4PJQ7.1
#=GS A0A4S2R749_9ACTN/12-117   AC A0A4S2R749.1
#=GS A0A1Q5LRT8_9ACTN/12-119   AC A0A1Q5LRT8.1
#=GS A0A4R4SUS7_9ACTN/9-119    AC A0A4R4SUS7.1
#=GS A0A1B6AUT4_9ACTN/12-127   AC A0A1B6AUT4.1
A0A2U2ZDW2_9ACTN/2-109               ...................................LAGYLLVMGYLALGLRVLRRDTVRPVP--......TGKR............GWPGLIRKVVGTAVGGYVLLMGVVVGY....YQGVARVGGHFLASAFTGCALLIGATLPVFLTASWLAER...WHARPSGRVDR..........
A0A345T3M5_9ACTN/105-209             ...................................LIGYLLLMATLGLGLRLLHRHLTGPPHT-......TARR............GWLGLARHTVGTAVGGYLLLMAVVFLY....YYGVARQSAHFLTSAVTGAAILVALAVPVFLALS----R...LRERRRPPGR-p.........
A0A3A9Z6Q2_9ACTN/7-115               ..................................a-AGYLLVMALLATGLRLMPGRAR-PPRRT......GTGL............GRPALLRQALATACGGWLLLTAVAAVF....ALVPGGLGGGFLWAAANGTALLTGLALPLFLAASLAETR...LRERRARRLRR..........
A0A4R4TFH5_9ACTN/11-121              ..................................c-VVYVLALIYLRIGLRIWRREPWAEPRRR.....hPERR............GWPELIRQVAATYVGGWLLLMVVIIFY....YGGVARRRPDFALHAATGTLSLMGITFPLFLAVYWLATR...PAV--------qrlaatmp..
A0A367YY37_9ACTN/19-133              hprthrrsadwaslrrglvllamtlllpgsaqlva-----------------------------......----............GNRRVGRAALRVWVGGWVLLLAFVVLAlvhrSTAVALLSGDFIWSALQATMVLAGVALVLLLVDAWRLAR...-----------pidmhrphrl
A0A0F7FZS3_9ACTN/11-121              ...................................CAGYVLLMIYLATGVRIIRADPRARPHRR.....rPERR............GRREFLRQVIGTYVGGWLLLMVVIVGY....YGGLARHNPSFVLHAVTGTLALMGLTLPLFLAASWAATR...RARRPARPGRR..........
A0A4R4TBV9_9ACTN/11-120              ..................................v-VVYVVTLVFLRVALRLWLREPHGRPRRR.....hPERR............GWPELIRQLALTYVGGWLLLMVVILCY....YGGLARHRPDFAVHAATGTLSLMGLTFPFFLAVTWLTTR...PAFRR------lvarl.....
A0A7M2SAS8_9ACTN/2-122               ...................................LTGYLLVMGCLAVGLRLLRRQSPGPRTAVr....gPDRRpvqplaagahgrGWPVLIRLVLGTAVGGYVLLMAVVVGY....YYGVARVGGRFLTSAFTGSALLVGITLPVFFAASWLAER...RRRRRV-----ae........
A0A561TV69_9ACTN/24-135              ...................................LAAYVLLMLYLAVGLRTLLRGPDRRPPRA.....aTGRR............GWPGLIRQVAATALGGYLLLMLAVLGY....YEGVARVPGPFLASAFSGCALLVGLALPVFLAASWLELR...PRARRGAGA--rgr.......
A0A365YPZ0_9ACTN/11-111              ...................................LTAYLLVMGYLAIGLRALLRDPGGGPRRR......SDRR............GWAELLRQVALTAIGGHALLLVVVAAY....YVAVAHHDREFVLGALTGTASLTGVALPVLLALTWLTHH...R----------g.........
A0A4R4PJQ7_9ACTN/11-124              .................................av--IYALVMIYLRVGVRLLREEPDGRPHRR.....hPERW............GWPEFARQLARTFVGGWLLLMLVIVGY....YGGIARHNGTFVWQAFTGTLSLMAIAYPLFLSMSWVFLKllyWRSRPRRRG--rp........
A0A4S2R749_9ACTN/12-117              ..................................a-TGYLLVMGCLAVGLRLARREGRDLPARRr....pATPT............GWPGLVRRVAGTAVGGYLVLMAVVVGY....YEGVAGLGGDFLAAVFTENLLLIGMVVPVFLVVSWVVAR...WRGR-------p.........
A0A1Q5LRT8_9ACTN/12-119              ...................................LTGYALVMGFLGCGLLILRRRPARPWPPArrvlagPGRR............GWPALVRQVAGTAIGGYVMLMAVVVGY....YQGVAHVGGRFLLSAVTGTALLIGITLPVYFLASWVTAR...RR---------g.........
A0A4R4SUS7_9ACTN/9-119               .................................av--IYVLVMIYLRVGVRLVREDPDGHPRRR.....hPERA............GWPEFARQLAGTFVGGWLLLMVVVVGY....FGGLARHNFDFVKDATTGTLSLMAVVYPLFLGLAWVRSR...IRARW------pgtgpg....
A0A1B6AUT4_9ACTN/12-127              ...................................LIGYLLVMGYLALGLRTLRRHPAESWQPPrrlapdAMRR............GWLGLIRQVVGTAVGGYVLLMAVSVGY....YRGVARVAPQFLASAFTGAATLIGITLPLFFIASWVVMA...VRRRSAGATRR..........
#=GC seq_cons                        ....................................suYlLVMsaLulGLRllRRcPss.PpRt.....tspRR............GWPtLlRQVsuTAVGGaLLLMsVVVGY....YtGVARhsucFlhuAhTGThhLhGlsLPlFLusSWlstR...hRtR.................
//