#=GF ID   DUF6257
#=GF AC   PF19771.3
#=GF DE   Family of unknown function (DUF6257)
#=GF AU   Williams LS;0000-0001-5551-8526
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Fragoso S;0000-0001-7018-3891
#=GF SE   Manual
#=GF GA   26.20 26.20;
#=GF TC   26.60 26.50;
#=GF NC   26.00 25.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   19362651
#=GF RT   Enzymology of aminoglycoside biosynthesis-deduction from gene
#=GF RT   clusters.
#=GF RA   Wehmeier UF, Piepersberg W;
#=GF RL   Methods Enzymol. 2009;459:459-491.
#=GF DR   INTERPRO; IPR046224;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents a member of a biosynthetic gene cluster
#=GF CC   (BGC). This BGC (BGC0000700) is described by MIBiG as an example
#=GF CC   of the following biosynthetic class, saccharide. It includes a
#=GF CC   member from the istamycin biosynthetic gene cluster from
#=GF CC   Streptomyces  tenjimariensis [1]. 
#=GF SQ   28
#=GS V6K0N9_STRRC/1-64      AC V6K0N9.1
#=GS A0A4U0SUE3_9ACTN/1-58  AC A0A4U0SUE3.1
#=GS A0A1X4I3W2_9ACTN/1-62  AC A0A1X4I3W2.1
#=GS A0A1G9V1N7_9ACTN/1-63  AC A0A1G9V1N7.1
#=GS A0A6B3AUL8_9ACTN/1-62  AC A0A6B3AUL8.1
#=GS S2Y240_9ACTN/1-61      AC S2Y240.1
#=GS A0A5Q0LQK2_9ACTN/3-63  AC A0A5Q0LQK2.1
#=GS A0A1C4JQU2_9ACTN/2-62  AC A0A1C4JQU2.1
#=GS A0A7K2KM92_9ACTN/6-66  AC A0A7K2KM92.1
#=GS A0A7L4Y3J8_9ACTN/6-66  AC A0A7L4Y3J8.1
#=GS A0A7U3VQ26_9ACTN/2-58  AC A0A7U3VQ26.1
#=GS F2RJJ6_STRVP/6-66      AC F2RJJ6.1
#=GS A0A1D2IMB7_9ACTN/1-62  AC A0A1D2IMB7.1
#=GS A0A1C4SM92_9ACTN/2-58  AC A0A1C4SM92.1
#=GS A0A6B3GFU0_9ACTN/1-58  AC A0A6B3GFU0.1
#=GS A0A7H8N989_9ACTN/2-66  AC A0A7H8N989.1
#=GS A0A081XUV4_STRTO/2-62  AC A0A081XUV4.1
#=GS I2N0W5_STRT9/4-69      AC I2N0W5.1
#=GS A0A1H6AD82_9ACTN/2-61  AC A0A1H6AD82.1
#=GS A0A0F4J6H9_9ACTN/1-58  AC A0A0F4J6H9.1
#=GS C9ZFA4_STRSW/2-60      AC C9ZFA4.1
#=GS A0A5Q4SXK7_9ACTN/1-64  AC A0A5Q4SXK7.1
#=GS A0A652KXS6_9ACTN/2-60  AC A0A652KXS6.1
#=GS A0A3R9VC32_9ACTN/1-61  AC A0A3R9VC32.1
#=GS A0A7K2KS91_9ACTN/7-67  AC A0A7K2KS91.1
#=GS A0A4U0SPC5_9ACTN/2-59  AC A0A4U0SPC5.1
#=GS A0A0D7CQZ3_9ACTN/1-60  AC A0A0D7CQZ3.1
#=GS A0A170WHY6_9ACTN/1-56  AC A0A170WHY6.1
V6K0N9_STRRC/1-64                 ..ms----SKQPRLTAGEKAQLAWYVARMAKRGLAddrqyGGRVDQSDLQRKYDRVLAQARKREERANK-d..
A0A4U0SUE3_9ACTN/1-58             ..ma-----AEPQLTAGEVARIALLVGRMCKRSIA.....GPDVHQADLERRIARIKEGARKRAEQAAKK...
A0A1X4I3W2_9ACTN/1-62             mpdg----LNLSDLTAGEKLRMAGLIARMAKRGLAd..dgTGNVDLSDLKRRFERIENQARRRKN-----ggk
A0A1G9V1N7_9ACTN/1-63             ..ma-----REPKLTTGEKAKVAWYVARMAKRGIAddrltGGRVHQRDLERKVERVIERARTREERDAKK...
A0A6B3AUL8_9ACTN/1-62             ....MADDLDLSDFTAGEKVRMAGLIARMAKRGLAd..dgTGRVDLSDLQRRFERIENQARRRKEQG---k..
S2Y240_9ACTN/1-61                 ....MADDLSWSDFTGGEKAHLIALHARMAKRGIA.....GPAVDLSDLQRKVRRIESRAERRKKSSKKK...
A0A5Q0LQK2_9ACTN/3-63             ..kp--DDLKLSDFTLVEMARMGVLLGRMAKRGIAd..dgTGNVDLSDLQRRAERIEKTALRRKAK----k..
A0A1C4JQU2_9ACTN/2-62             ...i-RTHPNDPPLTAGEATRLALLGARMAKRAIA.....GEAVDLSDLQGKFNRIIDGARARAEQASKT...
A0A7K2KM92_9ACTN/6-66             ...n-EYDPKHPPLTNGEKAKFAWYIGRMAKRGLA.....GETVYQGDLEKKVDRLLDGARARAEKNA--tr.
A0A7L4Y3J8_9ACTN/6-66             ...t-QPDPNSPKLTAGEHAKVAYYVARMAKRSIA.....GETVHMGDLERKVDRIINRARQRAERDEN-k..
A0A7U3VQ26_9ACTN/2-58             ...i-RTHPNDPPLTVIEAGRIARITAAAM---IR.....GGTL-TTDQKTAVDRILDGARKRAEKAAKK...
F2RJJ6_STRVP/6-66                 ...n-EYDPKHPPLTTGEKAKFAWYVGRMAKRGLA.....GESVYQGDLEAKVDRILDGARERAEKDAKR...
A0A1D2IMB7_9ACTN/1-62             ...m-----ADPKLTAGEITKLAWLTARMAKRGIAddrqnGGRIDQSDLQRKFDRVLEGARKREEQQSKR...
A0A1C4SM92_9ACTN/2-58             ...i-RTHPDDPPLTTREAADIARITALAALRG--.....--GVLTTRQENRIDRIIDGAHQRANKAA--ta.
A0A6B3GFU0_9ACTN/1-58             matp------EPQLTASEKAKAAWLIGRMAKRALA.....GPEVDQSDLEKKLDRLLDAARKREAKAK--t..
A0A7H8N989_9ACTN/2-66             akmq----QPAPRLTAGEKARVAVLVARMAKRGLAddrqmGGRVTQSDLQARVDRIIEGARKREEAAK--d..
A0A081XUV4_STRTO/2-62             tmdg----LNMSDFTAGEKVRLAGLIARMAKRGIAd..dgTGNVDLSDLKRKFERIENQARKRKN-----gk.
I2N0W5_STRT9/4-69                 ....YQADEREPRLTVGEKTQVALLVVRMAKRGLAddrqyGGRIDQGDLEKKVERIIERARLREERDGR-s..
A0A1H6AD82_9ACTN/2-61             ...i-HTHPNDPPLTTGEAARVAWLIARMGKRGLA.....GDDVDLTDLQRKLDRILNAARKRAEQNA--e..
A0A0F4J6H9_9ACTN/1-58             ..ma-----KDPNFTAREIAQIGWYTARMAKRGIA.....GENVHIGDLTRKVDRIIDTARERTEREER-e..
C9ZFA4_STRSW/2-60                 adnp---DIRFADFTTSEKLRVIALTARMAKRGAG.....GDGVDISDLQARVERIERQALRRKNK----k..
A0A5Q4SXK7_9ACTN/1-64             ....MARQQDEPQLTVGEKLRVAALVARMAKRGLAddrmsGGRVHQGDLERRVDRIVEGARKRQEKQ---r..
A0A652KXS6_9ACTN/2-60             ..sg--NDPNYPKLTAGEHARIAWNVARMCKRSMA.....GENVHQADLERKVDRIIDKARKRGEQG---k..
A0A3R9VC32_9ACTN/1-61             ....MAGTWDDVEFTAGEKAKLAWIVARMAKRGIA.....GDNVHIGDLKRRADRIEKTARKRMEQAEKN...
A0A7K2KS91_9ACTN/7-67             ...a-EYDPKHPPLTNGEKAKFAWYIGRMAKRGIA.....GESVYQGDLEKKVDRLLDGARARAEKNTR-q..
A0A4U0SPC5_9ACTN/2-59             .aav------EPQYTAAEKARITVLVARMCKRSVA.....GPDVHQADLVRRIDRIKEGARKRAEQAAKK...
A0A0D7CQZ3_9ACTN/1-60             .mar----HDDPKLTTTEKARIAVLVGRMCKRHIA.....GPDVHQRDLERRVDRILDGARERDKKNAR-q..
A0A170WHY6_9ACTN/1-56             matp------EPKLTLAEKAAIVRLELRGLRRAAA.....GI-TEQPDIDRQIARIKEKARLRAQ-----gqk
#=GC seq_cons                     .........pcPpLTsGEKA+lAhLlARMAKRGlA.....GssVcpuDLcR+lDRIl-sAR+RtEpst..t..
//