#=GF ID   DUF6258
#=GF AC   PF19772.3
#=GF DE   Family of unknown function (DUF6258)
#=GF AU   Williams LS;0000-0001-5551-8526
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Fragoso S;0000-0001-7018-3891
#=GF SE   Manual
#=GF GA   25.00 25.00;
#=GF TC   50.00 49.80;
#=GF NC   23.50 21.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   24981773
#=GF RT   Biosynthesis of crocacin involves an unusual hydrolytic release
#=GF RT   domain showing similarity to condensation domains.
#=GF RA   Muller S, Rachid S, Hoffmann T, Surup F, Volz C, Zaburannyi N,
#=GF RA   Muller R;
#=GF RL   Chem Biol. 2014;21:855-865.
#=GF DR   INTERPRO; IPR046225;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents a member of a biosynthetic gene cluster
#=GF CC   (BGC). This BGC (BGC0000974) is described by MIBiG as an example
#=GF CC   of the following biosynthetic classes, NRP (non-ribosomal
#=GF CC   peptide) and polyketide. It includes a member from the crocacin
#=GF CC   biosynthetic  gene cluster from Chondromyces crocatus [1]. 
#=GF SQ   12
#=GS A0A244EGR2_9BURK/1-131  AC A0A244EGR2.1
#=GS A0A0K1EE57_CHOCO/1-139  AC A0A0K1EE57.1
#=GS A0A7H0GGF2_9BURK/2-116  AC A0A7H0GGF2.1
#=GS A0A0Q6MN20_9BURK/4-137  AC A0A0Q6MN20.1
#=GS C3MDZ6_SINFN/1-130      AC C3MDZ6.1
#=GS K0B131_GOTA9/1-134      AC K0B131.1
#=GS A0A0Q8Q4V0_9BURK/8-141  AC A0A0Q8Q4V0.1
#=GS A0A2K9E1T3_9FIRM/1-133  AC A0A2K9E1T3.1
#=GS A0A1I1BEF5_9CLOT/1-136  AC A0A1I1BEF5.1
#=GS G8LZI9_ACECE/1-133      AC G8LZI9.1
#=GS A0A3A3FQM2_9BURK/1-134  AC A0A3A3FQM2.1
#=GS A0A428J438_9BACI/1-132  AC A0A428J438.1
A0A244EGR2_9BURK/1-131             ......MKPEEFLRTIYLGDRACKAIVMNGWKRELRIQIDCISRIR--SAQWDYYTAEDLPDGCLVFEGVESVVFEPSGKMPNDWIT..LVSVESV-.DEGPLHRFVFSAGAIDKHGKAVDVSIVIIAAAVALDD--NNDVRIR-v................................
A0A0K1EE57_CHOCO/1-139             ......MGPRDFLKTVYLGDRGCKGVFIDSWRERVTIHVNVISRVRGTSGAWDYYTDEDITDGHLVFTGVKSICFEPSGPLPNDFIYevLIEEELVStPGSEMFNASISVGSVGEEEAPTEVVIKIQAKGLHLEDPARPGQEIR-s................................
A0A7H0GGF2_9BURK/2-116             ilnqnq--------KIYLGDRAIQKIIFETMKNTITIVFDCLSIFE--TENWIPGESKDIENCAVKFMNVTDYEISPKGMMPNDYIV..NINIS---.-----------------------------------------------nsfvkittlgevynektlaldivegfisikfes
A0A0Q6MN20_9BURK/4-137             ......MDIIEFLKTIYIGDRGCKTILIDGWNSEVKVQATCISRVR--SATWDYYTAEDLPDGFIVFEGVTSVVFEPSGAIPNDSIN..DIRAERLA.GESAKYLIVMSIDAVDSAGNHVEVEMQIHANSMALEDHRKPGQRIT-r................................
C3MDZ6_SINFN/1-130                 ......MNPDEFLRSIYLGDRACKVIVLDGWKKEVKIQIDSISRLR--SGTWNY--DENIHDGFLVFEGVDHISFDPPGIIPNDDFG..DIEF--LG.FEDGRFTVMIDMGFCDEAGVYGSVKTKIRAKAVAIEKPGEEGTRIR-d................................
K0B131_GOTA9/1-134                 ......MNLEEFLETIYVGDRFIKSIIIDSQQKEVKIQFNLISRIRSSSGAWDFYNNENIENGLIVFTDIETFSFDPPEIIPNDELY..DWRIT--K.MDESGYEIDLYMGSYNNYGDHQEVKLKLKTKGIYLEDPLNQGTKIYN.................................
A0A0Q8Q4V0_9BURK/8-141             ......MALLEFLKTIYVGDRGCKSLIIDTWNREVKIQLTCISRVR--SKAWDYYDAEDLPNGFIVFEDVNSIVINPPGAMPNDTIN..DIRTEAIP.DRPGKYLVIVNVDSINEYGIRTEVDIQISAGSMALEAYGAAAKRITQ.................................
A0A2K9E1T3_9FIRM/1-133             ......MNAIDFLKTLYFGDRYCTKLLLDSANNKVELHINQVSRIRDKSGEWNYYTDEDIENGILVFTDIKKVFLDESGLLPNDQIY..DVYAN---.EHDGVYEFVIETSYVDASALTHDLTIRIIGEGVYLLDPTKPDVRIQ-d................................
A0A1I1BEF5_9CLOT/1-136             ......MNPKEFINTIYLGDRFCKSILIDGYNERVKIQINTISRIRSESGNWEYYNDENIEDGLIVFTGVKSILLEPQGFIPNDEIE..LVSAELIE.DDEESFIFNISAASCDQQGRCTRVEMKIIAEAIHLEDPTRQGVEIN-e................................
G8LZI9_ACECE/1-133                 ......MNAIDFLKTLYFGDRYCTKFLLDSTNNKVELHVNQISRIRDKSGEWNYYTDEDIENGVLVFTGIKKVFLDESGLLPNDQIY..DVYAN---.EHDGIYEFVIETSHVDVNALTYDLTIRIIGEGVYLLDPAKPDVRIQ-d................................
A0A3A3FQM2_9BURK/1-134             ......MNVIEFLKTIYLGERGCKSLLIDGWNSEVKMQVTCISRVR--SESWNYYDAEDLIDGYIVFEGVESIVLDPPGILPNDSIN..DIRAEQLA.DNLGKYLIIVNVNSVSASGEHSELEIRIQATSIALEAHDEPGKRITQ.................................
A0A428J438_9BACI/1-132             ....mn-NPIEFLNTIYFGDRYCERINIEG--DVVELQINLVSRIRRNSGEWNFYSAEDIENGVLVFSGVEEVQYDDTELLPNDEIY..NISVK---.PLENNYEFKIEAGHVNQNAEHYDVIIILIAKELYLKDPKNPNTKIV-n................................
#=GC seq_cons                      ......MsshEFL+TIYlGDRhCKslllDuhppcVclQlssISRlR..SusWsYYssEDIpsGhlVFpGVcslhh-PsGhlPNDpIh..slpsp.....cpsha.hhlpsutlsptu.ph-VplpIhApulhL-D.tpssh+Ip.p................................
//