#=GF ID DUF6315
#=GF AC PF19836.3
#=GF DE Family of unknown function (DUF6315)
#=GF AU Williams LS;0000-0001-5551-8526
#=GF AU Finn RD;0000-0001-8626-2148
#=GF AU Fragoso S;0000-0001-7018-3891
#=GF SE Manual
#=GF GA 29.70 29.70;
#=GF TC 295.50 295.30;
#=GF NC 27.50 27.50;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF WK Domain_of_unknown_function
#=GF RN [1]
#=GF RM 23360970
#=GF RT Cloning and sequencing of the kedarcidin biosynthetic gene
#=GF RT cluster from Streptoalloteichus sp. ATCC 53650 revealing new
#=GF RT insights into biosynthesis of the enediyne family of antitumor
#=GF RT antibiotics.
#=GF RA Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y,
#=GF RA Wendt-Pienkowski E, Shen B;
#=GF RL Mol Biosyst. 2013;9:478-491.
#=GF DR INTERPRO; IPR045631;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This entry represents a member of a biosynthetic gene cluster
#=GF CC (BGC). This BGC (BGC0000081) is described by MIBiG as an example
#=GF CC of the following biosynthetic class, polyketide, in particular
#=GF CC the kedarcidin biosynthetic gene cluster from Streptoalloteichus
#=GF CC sp. ATCC 53650 [1].
#=GF SQ 23
#=GS D7B360_NOCDD/1-175 AC D7B360.1
#=GS A0A840WK88_9ACTN/1-157 AC A0A840WK88.1
#=GS A0A2P8DU43_9ACTN/1-174 AC A0A2P8DU43.1
#=GS A0A2T0Q0U6_9ACTN/1-174 AC A0A2T0Q0U6.1
#=GS A0A7W8VGN7_9ACTN/1-158 AC A0A7W8VGN7.1
#=GS A0A1M6MPX1_9ACTN/1-174 AC A0A1M6MPX1.1
#=GS A0A543NKE6_9ACTN/1-174 AC A0A543NKE6.1
#=GS A0A4V3D7K1_9ACTN/1-174 AC A0A4V3D7K1.1
#=GS A0A852TS27_9ACTN/1-174 AC A0A852TS27.1
#=GS A0A853BVN8_9ACTN/1-174 AC A0A853BVN8.1
#=GS A0A368T506_9ACTN/1-174 AC A0A368T506.1
#=GS A0A1Q9THT3_9ACTN/1-174 AC A0A1Q9THT3.1
#=GS A0A1T4SN38_9ACTN/1-174 AC A0A1T4SN38.1
#=GS A0A3N0EHL2_9ACTN/1-174 AC A0A3N0EHL2.1
#=GS A0A399G156_9ACTN/1-174 AC A0A399G156.1
#=GS A0A0C2G4H7_9ACTN/1-174 AC A0A0C2G4H7.1
#=GS A0A841ISB3_9ACTN/1-174 AC A0A841ISB3.1
#=GS J7L297_NOCAA/1-174 AC J7L297.1
#=GS A0A7W7RKB9_9ACTN/1-174 AC A0A7W7RKB9.1
#=GS A0A0M8XZ44_9ACTN/1-175 AC A0A0M8XZ44.1
#=GS A0A223S4M6_9ACTN/1-174 AC A0A223S4M6.1
#=GS A0A1R3UVQ5_9ACTN/1-161 AC A0A1R3UVQ5.1
#=GS A0A4P6Q3W7_9ACTN/1-174 AC A0A4P6Q3W7.1
D7B360_NOCDD/1-175 .MKQDLTALCCDCGTIREVSDYQSVGEAQSAYGLARCVVWRKCRTCGYRTYHAYMRADEDRDELEDALRLDGALAAEALDEEVEQLRLCGVEVGHAPVPAIWDGQSVGMVTQRLTDRAYSIVLDPEASVVSRLKLIDMMWNELLVGEHDDRWFIQEAEDDgSPAYAVRLFGYRTR-g
A0A840WK88_9ACTN/1-157 m------------------SDHQSVGEAQSAYGLARCVVWRKCRPCGYRTYHAYLRADEDRDELEDALRLDGALAAEALDEEVEQLRLCGIEVGHAPVPAIWDGQSVGMVTQRLTDHAYSIVLDPEASVVSRLKLIDMMWNELLVGEHDDRWQIQEPEDD.SPGYAVRLFGYRTR-g
A0A2P8DU43_9ACTN/1-174 .MKQELTALCCACGATRRVSEYRGVGEAQSAYGLARCVVWRMCRPCGHRTHHAYLRADTDRDELEDALRLDDALATEALDEEIEQLKLCGVDIGHAPVPAIWNGQPVGMVTQRLTDSAYAIVLDPSSSVVARLKLIDLMWNELAIGDHDDRWYIQPSDDD.SPGYAVRLFGYRTP-r
A0A2T0Q0U6_9ACTN/1-174 .MTQTLTALCCQCGNTRAVSTHRHVGEAQSAYGFARCVVWRKCAVCGEQTTHAYLRDDPERDELEDALNLDDALAAEALDEEVDQLRQCGVEVGHAPVPAVWDGQPVGMLTRRLDDHAYAIVLDPGSSVVARLKLIDLLWNELMTGGAEGHWYIQPGEGR.RPGYAVRLFGYRVP-r
A0A7W8VGN7_9ACTN/1-158 m------------------SDYQGIGEAQSAYGLARCVVRRLCRTCGHRTYHAYLRDDADRDELEEALKLDDAMAGEALEEEIQQLRLCDVEIGHAPVPAVWDGQPVGMVTQRLADRSYSVVLDPGASVVARLKLIDLVWSELATGEHDDRWQFQPGEDDeSPGYAVRLFGYRLRR.
A0A1M6MPX1_9ACTN/1-174 .MKQDLTALCCDCGTIREVSDYQSVGEAQSAYGLARCVVWRKCRTCNRRTYHAYLRADEDRDELEDALRLDGALAAEALDEEVEQLRLCGVDVGHAPVPAIWDGQSVGMVTQRLTDRAYSIVLDPEASVVSRLKLIDMMWNELLVGEHDDRWFIQESEDD.SPGYAVRLFGYRTR-g
A0A543NKE6_9ACTN/1-174 .MKQDLTALCCECGASRQVSSYRGIGEAQSAYGLARCVVWRMCAACGYRTYHAYLRNDEDRDELEDALRLDEELATEALDEEVEQLRLCGVDIGHAPVPAIWDGQSVGMVTQRLTDHSYAIVLDPHSSVAARLKLVDMLWNELTIGDHEDRWYIQPSDDE.TPGYAVRLFGYRLRR.
A0A4V3D7K1_9ACTN/1-174 .MKQELTALCCDCGAIRQVSAYRGIGEAQSAYGLARCVVWRLCRACGHRTYHAYMRTDEDRDELEEALRLDDALAAEALDEEVEQLRLCGVEIGHAPVPAIWNGQPVGMVTQRLSDQAYSIVLDPNASVVARLKLIDLVWNELSIGDHDDRWYIQPADNE.NPGYAVRLFGFRAKR.
A0A852TS27_9ACTN/1-174 .MKQELTALCCDCGAIRRVSAYRGIGEAQSAYGLARCVVWRLCRPCGHRTYHAYLRTDDDRDELEDALKLDDALAAEALDEEIEQMRLCGVEIGHAPVPAIWDGQPVGMVTQRLTDHSYAIVLDPNASVVARLKLIDLMWNELSIGDHDDRWYIHPADDE.SPGYAVRLFGYRLRR.
A0A853BVN8_9ACTN/1-174 .MKQDLTALCCECGTSRPVSAYRAIGEAQSAYGLARCVVWRACRTCGYRTYHAYLRDDPDRDELEDALKLDDALAAEALDEEMEQLRLCGVDIGHAPVPAIWDGQPVGMVTQRLTDLSYAIVLDPNASLVARLKLIDLMWNELSTGDNDDRWYIQPADED.TPGYAVRLFGYRVRR.
A0A368T506_9ACTN/1-174 .MKQELTALCCECGAIREVSARRGVGEAQSAYGVARCVVRCMCGFCGERTYHAYLRDDIDRDELEDALKLDDALAAEALDEEIEQLRLCGVDIGHAPVPAIWDGQPVGMVTQRLTDHAYAIVLDPNASVVARLKLIDLMWNELAIGDHDDRWYIQPSDDE.SPGYAVRLFGYRVRR.
A0A1Q9THT3_9ACTN/1-174 .MKQDLTALCCECGMIRGVSDYQSVGEAQSAYGVARCVVWRKCRKCGYRTYHAYLRGDEDRDELEDALRLDGALAAEALDEEVEQLRLCGVEVGHAPVPAIWDGQSVGMVTQRLTDQTYSIVLDPEASVVSRLKLIDMMWNELLVGAHDDRWYIQEPEDD.SPGYAIRLFGFRDR-r
A0A1T4SN38_9ACTN/1-174 .MEQNLTALCCECGAIRTVSTYRGIGEAQSAYGLARCVVWRMCRVCGHRTYHAYLRADEERDELEEALDLDDALAAEALDEEIEQLRLCGIDIGHAPVPAIWDGQPVGMVTQRLTDHAYAIVLDPNASVVARLKLIDLMWNELSIGDHDDRWYIHPADDE.SPGYAVRLFGYRVRR.
A0A3N0EHL2_9ACTN/1-174 .MKQDLTALCCECGATRTVSAYRGIGEAQSAYGLARCVVWRMCRPCGRRTYHAYLRDDDERDELEDALKLDDALAAEALEEEIEQLRLCGIDIGHATVPAIWDGQSVGMVTQRLTDHSYSIVLDPGASVVSRLKLIDLMWNELSIGEHHDRWHIQPADDE.SPGYAVRLFGYRVP-r
A0A399G156_9ACTN/1-174 .MKQELTALCCDCGAIRRVSAHRGIGEAQSAYGAARCVVWRLCRPCGRRTYHAYMRNDADRDELEDALRLDDALAAEALDEEVEQLRLCGVDVGHAPVPAIWDSQPVGMITQRLSDRAYSLVLDPNSSVVARLKLIDLMWCELTTGEHDGRWHIEPPDGD.SPGYAVRLFGFGST-h
A0A0C2G4H7_9ACTN/1-174 .MKQELTALCCECGTSRMVSAYRAIGEAQSAYGLARCVVWRLCRACGHRTYHAYLRDDEDRDELEDALQLDQALASEALDEEVEQLRLCGVDIGHAPVPAIWDGQPVGMVTQRLSDHSYAIVLDPSSSVVARLKLIDLMWNELAIGDNDDRWYIQPADDD.TPGYAVRLFGYRLRR.
A0A841ISB3_9ACTN/1-174 .MKQDLTALCCECGSMREVSDYRSVGEAQSAYGLARCVVWRKCRTCGCRTYHAYLRGDEDRDELEDALRLDGALAAEALDEEVEQLRLCGVEVGHAPVPAIWGGQSVAMVTQRLTDRSYSIVLDPEASVVSRLKLIDMMWNELLVGEHDDRWYIHEAEDD.SPGYAVRLFGYRTR-g
J7L297_NOCAA/1-174 .MKQDLTALCCECGMIRKVSDYQSVGEAQSAYGLARCVVWRKCRSCDYRTYHAYLRSDEDRDELEDALRLDGALAAEALDEEVEQLRLCGVEVGHATVPAIWDGQSVGMVTQRLTDHSYSIVLDPEASVVSRLKLIDMMWSELLVGEHDDRWHIQEPEDD.SPGYAVRLFGYRTR-g
A0A7W7RKB9_9ACTN/1-174 .MKQDLTALCCECGATRTVSAYRGIGEAQSAYGLARCVVWRMCRSCGRRTYHAYLRDDDERDELEDALKLDDALAAEALDEEIEQLRLCGIDIGHATVPAIWDGQSVGMVTQRLTDHSYSIVLDPGASVVSRLKLIDLMWNELSIGEHHDRWHIQPADEE.SPGYAVRLFGYRVP-r
A0A0M8XZ44_9ACTN/1-175 .MKQDLTALCCECGMKRVVSDYQSVGEAQSAYGLARCVVWRKCRACGYRTYHAYLRADEERDELEDALRLDGALAAEALDEEVEQLRLCGVDIGHAPVPAIWDGQSVGMVTQRLTDHAYSIVLDPEASVVSRLKLIDMMWNELLVGDHDDRWYIQESEDEkTPGYAVRLFGYRTR-g
A0A223S4M6_9ACTN/1-174 .MKRDLTALCCDCGAIRQVSAHNGIGEAQSAYGHARCVVRRVCRSCGYRTDHAYLRDDADRDELEDALKLDDALAAEALDEEVEQLRLCGIDIGHAPVPAIWDGQPVGMVTQRLSDRSYAIVLDPESSVVARLKLIDMIWNELSIGDNEDRWYIQPAEDD.SPGYAVRLFGYRVRR.
A0A1R3UVQ5_9ACTN/1-161 .-------------MVREVSEYRSVGEAQSAYGLARCVVWRKCRTCGYRTYHAYLRPDEERDELEDALRLDGALAAEALEEEVEQLRLCGVEIGHATVPAIWDGQSVGMVTQRLTDQAYSIVLDPEASVVSRLKLIDMMWNELLVGDHDERWHIHEPEDD.SPGYAVRLFGYRTR-g
A0A4P6Q3W7_9ACTN/1-174 .MKQDLTALCCECGTSRKVSAYRAIGEAQSAYGLARCVVWRLCRTCGHRTYHAYLRDDEDRDELEEALDLDDALAAEALDEEVEQLRLCGVDIGHAPVPAIWDGQPVGMVTQRLTDLSYAIVLDPSSSVAARLKLIDLMWNELSIGDNDDRWYIQPADDD.TPGYAVRLFGYRVRR.
#=GC seq_cons .MKQ-LTALCC-CGshRpVSsYRulGEAQSAYGLARCVVWRhCRsCGaRTYHAYLRsD-DRDELEDAL+LD-ALAAEALDEEVEQLRLCGV-IGHAPVPAIWDGQsVGMVTQRLTD+uYuIVLDPpASVVuRLKLIDhMWNELslG-HDDRWYIQPu-DD.SPGYAVRLFGYRsR..
//
