#=GF ID DUF6317
#=GF AC PF19840.3
#=GF DE Family of unknown function (DUF6317)
#=GF AU Williams LS;0000-0001-5551-8526
#=GF AU Finn RD;0000-0001-8626-2148
#=GF AU Fragoso S;0000-0001-7018-3891
#=GF SE Manual
#=GF GA 27.40 27.40;
#=GF TC 27.50 27.40;
#=GF NC 27.30 27.30;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Family
#=GF WK Domain_of_unknown_function
#=GF RN [1]
#=GF RM 29324854
#=GF RT Characterization of the biosynthetic gene cluster for cryptic
#=GF RT phthoxazolin A in Streptomyces avermitilis.
#=GF RA Suroto DA, Kitani S, Arai M, Ikeda H, Nihira T;
#=GF RL PLoS One. 2018;13:e0190973.
#=GF DR INTERPRO; IPR045558;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This entry represents a member of a biosynthetic gene cluster
#=GF CC (BGC). This BGC (BGC0001740) is described by MIBiG as an example
#=GF CC of the following biosynthetic classes, NRP (non-ribosomal
#=GF CC peptide) and polyketide, in particular the phthoxazolin
#=GF CC biosynthetic gene cluster from Streptomyces avermitilis [1].
#=GF SQ 44
#=GS A0A0M8VDI3_9ACTN/16-115 AC A0A0M8VDI3.1
#=GS A0A250VQB9_STROL/1-100 AC A0A250VQB9.1
#=GS A0A1J4NYV9_9ACTN/1-100 AC A0A1J4NYV9.1
#=GS A0A1S2QLU5_9ACTN/1-83 AC A0A1S2QLU5.1
#=GS A0A0G3AFC6_9ACTN/1-100 AC A0A0G3AFC6.1
#=GS A0A4R1DIB6_9ACTN/1-98 AC A0A4R1DIB6.1
#=GS A0A2G1XG12_STRCJ/1-100 AC A0A2G1XG12.1
#=GS A0A420XN06_9ACTN/1-98 AC A0A420XN06.1
#=GS A0A4R7MND9_9ACTN/1-98 AC A0A4R7MND9.1
#=GS A0A7I7SDD4_9MYCO/1-107 AC A0A7I7SDD4.1
#=GS A0A0L8QIF2_9ACTN/1-99 AC A0A0L8QIF2.1
#=GS A0A1B1AVB2_9ACTN/1-96 AC A0A1B1AVB2.1
#=GS A0A1H0UHB1_9ACTN/1-101 AC A0A1H0UHB1.1
#=GS A0A2A2Z1V8_9ACTN/1-100 AC A0A2A2Z1V8.1
#=GS A0A1J4PVD7_9ACTN/1-100 AC A0A1J4PVD7.1
#=GS D6ZCV5_SEGRD/1-100 AC D6ZCV5.1
#=GS A0A540W8S9_9ACTN/1-101 AC A0A540W8S9.1
#=GS A0A101TCB1_9ACTN/1-86 AC A0A101TCB1.1
#=GS A0A0L8LFK6_9ACTN/1-100 AC A0A0L8LFK6.1
#=GS A0A0Q9AE43_9ACTN/1-100 AC A0A0Q9AE43.1
#=GS A0A5A7SIV1_9NOCA/1-98 AC A0A5A7SIV1.1
#=GS A0A561UEV0_9ACTN/1-99 AC A0A561UEV0.1
#=GS A0A5A7S940_9NOCA/1-99 AC A0A5A7S940.1
#=GS A0A370I4T3_9NOCA/1-100 AC A0A370I4T3.1
#=GS A0A0N1GW49_9ACTN/1-100 AC A0A0N1GW49.1
#=GS A0A7Y7EAJ2_STRMO/1-100 AC A0A7Y7EAJ2.1
#=GS A0A1M5WPA2_9ACTN/1-100 AC A0A1M5WPA2.1
#=GS A0A561UMN0_9ACTN/1-97 AC A0A561UMN0.1
#=GS A0A1H5DLL0_9ACTN/1-100 AC A0A1H5DLL0.1
#=GS A0A0M9YAY2_9ACTN/1-100 AC A0A0M9YAY2.1
#=GS A0A197SHR4_9ACTN/1-96 AC A0A197SHR4.1
#=GS A0A117PY76_9ACTN/1-86 AC A0A117PY76.1
#=GS M3C778_STRMB/1-100 AC M3C778.1
#=GS A0A543CFX4_9ACTN/1-92 AC A0A543CFX4.1
#=GS A0A1K2FS40_9ACTN/1-100 AC A0A1K2FS40.1
#=GS S5UZE7_STRC3/1-99 AC S5UZE7.1
#=GS A0A0M9YPC6_9ACTN/1-100 AC A0A0M9YPC6.1
#=GS A0A0L0KP23_9ACTN/1-98 AC A0A0L0KP23.1
#=GS A0A176L671_9ACTN/1-100 AC A0A176L671.1
#=GS F8JXD9_STREN/1-100 AC F8JXD9.1
#=GS A0A0K9XI58_9ACTN/1-100 AC A0A0K9XI58.1
#=GS A0A1H9UFI4_9ACTN/1-100 AC A0A1H9UFI4.1
#=GS A0A8J3BZR8_9ACTN/1-102 AC A0A8J3BZR8.1
#=GS A0A1S2PRX2_9ACTN/1-99 AC A0A1S2PRX2.1
A0A0M8VDI3_9ACTN/16-115 ......v-TADFKVIYDDLSTLAKTFHDEAGNYRKLHPDV..APPVVS.GGDAGLDSAIKEVSDLIISLHDLLADRMDDHGDKAVYARNSFHRHDV......D.VHGVFEDLMPDE-g.............
A0A250VQB9_STROL/1-100 .......MPPDFKAVLSDLTSTSKTFHDEATHYRNLHDQI..APPVVS.GGDSGLDHAIKEVADLIVALHTGFADRLDDHGDKVAYARDSFQRHDI......D.VHGLFEDLMVGD-g.............
A0A1J4NYV9_9ACTN/1-100 .......MMADFQAVMSDLTAMTKTFHDQARDYRGLGPDV..TPPVAD.SGDGGCDHAIKEIADLIVALHIGFADRLDDHGDKVAYARDSFQRHDV......D.VHGVFEDLMTGE-g.............
A0A1S2QLU5_9ACTN/1-83 .......--------------MASTFHTEAKSYAKLHTSV..SPAVAK.SGDDGLDHTIGSMMDAISGLHARLAGRIEEHGDLLDAAVKHLTHRDI......D.VHGLFEDLM----g.............
A0A0G3AFC6_9ACTN/1-100 .......MTADFKVVYSDLSTLAKTFHDEAGNYRKLHPDV..APPVVS.GGDPGLDSAIKEVADLIVSLHLLLADRMDDHGDKAAYARDSFHRHDV......D.VHGVFQDLMPD--gg............
A0A4R1DIB6_9ACTN/1-98 .....mt---RISVPLEDLDETVKSLEDIGERINNTARLS.nVGSKDD.VGDSTLADALAEFDDAWGKGHEKVQDNVKVFSENTKKISDAFTQTDD......E.TVKALDD------skkt..........
A0A2G1XG12_STRCJ/1-100 .......MSDELRTTVEHIDDAGKGFHREAIHLGEFKHLA..SPATPG.VGDLALSSALVQLSDAFGIAHELLTGLVDRHGTSLRGAAADYQDQDV......D.IETLFRDMMGKAK..............
A0A420XN06_9ACTN/1-98 .......MADSFELVLADLQSMSGRFAKEADVYDASHSDV..TPAQAA.TGDGSLDGTLRAVMEALDILHTSMGETIREHGEKLKAARESYERHDV......D.VHGLFDDLME---g.............
A0A4R7MND9_9ACTN/1-98 .......MGSGYQVVLGDLQRMADTYHSEADAYRGLKPQV..APAVAD.GGDTGLNDSIQLIMAAIDSIHTKLADRIEEHGDKLAYVHGSYQRRDV......D.VHGAFEDLMA---e.............
A0A7I7SDD4_9MYCO/1-107 .......MMSEFKVVLNDLDQLRRSLAGGAASYEQIIPSV..NPPPVD.GGDGNLNSVLQALTETFAVGHAAVVDSLEGRAAKVKSARDTFDRVDSgayfqwDgTRSLYDDMVPE--ed............
A0A0L8QIF2_9ACTN/1-99 ......m--ADLKAVLGDLKSMAGTFHREAGNYRKLKENV..SPPIVS.GGDPGLDHAIVSMADIIIAMHTGFADRLDDHGDKVHEAHDSYQRHDI......D.VHGLFEDLMKDEK..............
A0A1B1AVB2_9ACTN/1-96 .......MS-DFKVVYDDLSTMAKTFHDQAGDYRKLRPDV..APPVVS.GGDAGLDSAIKEVADLIIALHIGMADRLDDHGDKVAYARDSFHRHDV......D.VHGVFEDLM----g.............
A0A1H0UHB1_9ACTN/1-101 .......MAGEFKVDLDHLKSFGDTLKRSVEELEGARKAL..ADVRADqIGTPRLDEACDTFQDRWAYGTDQLKDLIKAVGEGVETTMLSYKKFEE......-.-------------elskalkqmndtaa
A0A2A2Z1V8_9ACTN/1-100 .......MSVDFKAVLSDLTSMSKTFHDEAVNYRKLHADV..APPLVS.GGDAGLDHAIKEVADLIVALHIGFADRLDDHGDKVTYARDSFQRHDI......D.VHGLFEDLMADD-g.............
A0A1J4PVD7_9ACTN/1-100 .......MTADFKVVYDDLTGLAKAFHEQAGDYRKLAPDV..SPAIVG.GGDPALDSAIKEVADLIIGLHTGLADRMDDHGDKAAYARDSFHRHDV......D.IHGVFEDLTEG--ld............
D6ZCV5_SEGRD/1-100 .......MGDWSKVVLDDLAAMSQQFEQGHADFEAAVEAV..KAEPVD.TGDGTLNDYLQYVTGRIEELTIKSAELIKEHAGKVKYAHDSYERHDI......D.NEELFEDMDFEY-k.............
A0A540W8S9_9ACTN/1-101 msgsgyg------VLLGDLQALADDFGTEAKAVQQLHGDV..DLKPVS.TGDANLDATLGAVLMNLKGLIDGTAKQLGDHGSKMQSCHDNYKSSDS......D.HARLLDSLMSA--an............
A0A101TCB1_9ACTN/1-86 .......--------------MAKTFHEQAGDYRKLHADV..APPVVS.GGDPGLDAAIKEVADLIVALHLGMADRMDDHGDKVAYARDSFHRHDV......D.VHGVFEDLMAGE-g.............
A0A0L8LFK6_9ACTN/1-100 .......MPADFKAILSDLTSMSRTFHDEAVNYRKLHTDV..APPVAD.GGDAGLDHALKEVAELIVGLHTGFADRLDDHGDNVAHARDSFQRHDI......D.VHGLFEDLTVGD-g.............
A0A0Q9AE43_9ACTN/1-100 .......MPPDFKAVLGDLTAMSTTFHDEAVNYRKLHADV..APPLAG.GGDAGLDHALKEVADLIVALHIGFADRLDDHGDKVTYARDSFRRHDI......D.VHGLFEDLMTED-g.............
A0A5A7SIV1_9NOCA/1-98 ......m--ADFKVVLDDLKLMANDFDQNSEVYRGLARQV..SPPAAD.TGNGDVNAVLRSITEAFAVLHEKLATSIQNHADKLYDAHDSYQDREI......D.NRFLFDEIVE---dl............
A0A561UEV0_9ACTN/1-99 ......m-S-QYTVVLDDLKGAADTFHQESKTFAGIMPDD..GPAQVD.GGDGAVNAMMQTVFEALGGLHLAVAGSISNHGDNLQKAHDNYQNCEV......S.VRELYDDIS----epss..........
A0A5A7S940_9NOCA/1-99 ......m--AGFEVVLEDLQSMATTFNEQAGAYRAVTPKL..TPAEAD.SGDGALNAVMHAVLELIGVLHQQLATSITQHSEKLATAHDSYQRRDI......D.NRFLFDDLMKDV-d.............
A0A370I4T3_9NOCA/1-100 .......MSDWFQVVLDDLKTMAKTFDDEAKTYEGLVPKF..SPAPVD.SGDATLNEAMKGAADLLQILHHQMVRTIQTHAEKLSYARDSYERHDI......D.NRKLYDDLTKN--ld............
A0A0N1GW49_9ACTN/1-100 .......MTVDFKAVLSDLASMSRTFHDEAVNYRKLHADV..SPPLAG.GGDAGLDHAVKEVADLIVALHIGFADRLDDHGDKVTYARDSFQRHDI......D.VHGLFEDLMAGD-g.............
A0A7Y7EAJ2_STRMO/1-100 .......MSDKLRATVDHIDDTGRAFQREAVDLGRTAHLA..SPPTPG.VGDVALSSALLRLSDAFGAAHRMMTGLIDGHGSKLRKAAADYQNTDI......D.LHGMFDDLIDKY-k.............
A0A1M5WPA2_9ACTN/1-100 .......MPPDFKAVLGDLTSMSKTFHDEAVNYRKLHADV..APPLVS.GGDAGLDHALKEVADLIVALHIGFADRLDDHGDKVTYASDSFQRHDI......D.VHGLFEDLMAGD-g.............
A0A561UMN0_9ACTN/1-97 .......MSAGYDVVLEDLRSMAATFHQEAQAYVKLKTDV..APPIAA.SGDSGLDSSITSMMEAIAGLHAKLAGRIEGHGDKLQYAHDSYQRHDV......D.EHGVYEDLM----n.............
A0A1H5DLL0_9ACTN/1-100 .......MSADFKAVLSDLTSMATTFHDQATDYRKLQPQV..SPPVVS.GGDAGLDDAIKEVAHLILGLHIGFADRLDDHGDKVAYARDSFHRHDV......D.VHGVFEDLMVGD-g.............
A0A0M9YAY2_9ACTN/1-100 .......MSVDLKLVLADLNAMAGTFHKEADNYRRMHQNV..KPAIVG.SGDAGCDAAIKAVADLIAGLHDKLSDRLDDRSDKLKYAHDSMARHDI......D.VHGLFDDLMKD--rt............
A0A197SHR4_9ACTN/1-96 .......MSADVKVILADLNSMASAFREEAGIYRGMHANV..KPGAAG.SGDPGCDAAIKSMADLIAGLHDKLSDRLDDNSDKVKYAHDSMQRNDI......D.VHGLFEDLM----..............
A0A117PY76_9ACTN/1-86 .......--------------MAKTFHDEAGDYRKLHPDV..APPVVS.GGDAGLDSAVKEVADLIISLHIGMADRMDDHGDKVAYARDSFHRHDV......D.VHGVFEDLMAGE-s.............
M3C778_STRMB/1-100 .......MSDRLKATVEHIDDAGKGFHREALHLGEFRQLA..APPTPG.VGDIALSSALFRLSEAFGIGHELLTNLVEKHGGNLRTAAGDYQNQDI......D.TQKILSDLMGK--vs............
A0A543CFX4_9ACTN/1-92 ....msg----YDVIFDDLVKASAEFSKQGEAYANLMPH-..KPACPA.GGDDAIDKMLNVTLQALYEMHTVLAQSISAHAYKLDYAHRHYSKVER......D.V------------fdhive........
A0A1K2FS40_9ACTN/1-100 .......MTADFKVIYDDLSTLAKTFHDQAGDYRKLAPDV..SPPIVS.GGDPALDAAIKEVANLVIALHIGLADHLDDRGDKAAYARDSFHRHDV......D.IHGVFEDLTEG--ld............
S5UZE7_STRC3/1-99 .......MS-DFKAVYDDLAAMARTFHEQAGDYRKLRPDV..APPVAA.GGDAALDSAIKEVADLIVALHAGMADRMDDHGDKVAYARDSFHRHDV......D.VHGVFEDLMAGE-g.............
A0A0M9YPC6_9ACTN/1-100 .......MAADFKAILSDLSSMSKTFHDEAVNYRKLHSDV..APPVAG.GGDAGLDHAIKEVADLIVALHIGFADRLDDHGDKVTYAHDSFQRHDI......D.VHGLFEDLMVGD-g.............
A0A0L0KP23_9ACTN/1-98 ......m---DFNVVLGDLTSMASTLHTEATNYRALHGQV..TPAVVS.GGDPALDHAVSEAAHLISGLHTLFADRMDDHGDKVAYARDSFHRHDI......D.VHGLFEDLMKGE-g.............
A0A176L671_9ACTN/1-100 .......MSADFKVIYDDLSTLAKTFHDEAGDFRKLHGDV..APPVVS.GGDPGLDSAIKEVSHLIIGLHVLLADRMDAHGDKVAYARDSFHRHDV......D.VHGVFEDLMPDE-d.............
F8JXD9_STREN/1-100 .......MTADLKAVLGDLKATGDAFHRAADDYRGLTPHV..SPALAD.GGDPGLNDAIREVSDLIRALHTAFADRLRSHGDQVHHAHDAYQRQDD......D.THQLFDDLMHGD-g.............
A0A0K9XI58_9ACTN/1-100 .......MADKLRATVEHIDEAGKGFHREALHLGEFKHLA..SPSTPR.VGDAGLSEALSVLSEAFGLAHELLTGLVDTHGTNLRGAASDYHHEDL......D.RRKMFDDLMGRA-k.............
A0A1H9UFI4_9ACTN/1-100 .......MPPDFKAVLGDLTAMSKTFHDEAVNYRKLHADV..APPLVS.GGDTGLDHALKEVADLIVALHTGFADRLDDHGDKVTYARDSFQRHDI......D.VHGLFDDLMEGD-g.............
A0A8J3BZR8_9ACTN/1-102 .......MGDDYHVAVSRGTALADTFARAQDPLLRLAAPLrgACEAIR.TGDAGLDAETAAVARRVDGLYRLMAQVFATLSANVSDAVADYRDADE......A.VAAAFRELMSDD-t.............
A0A1S2PRX2_9ACTN/1-99 .......MTADFKVIYDDLATLAKTFHDESGNYRKLAPDV..TPAVVS.GGDPGLDDTIKAVADLITSMHLALADRLDEHGDKAGYARDSFHRHDV......D.VHGVFEDLTPE--d.............
#=GC seq_cons .......Mss-a+sllsDLsshucTFHcEAssYRcL+ssV..uPslsu.uGDsuLDsAl+pVu-lIsuLHtthADRlD-HGDKlsYA+DSapRHDl......D.VHGlF-DLM.t..s.............
//
