#=GF ID   DUF6333
#=GF AC   PF19859.3
#=GF DE   Family of unknown function (DUF6333)
#=GF AU   Williams LS;0000-0001-5551-8526
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Fragoso S;0000-0001-7018-3891
#=GF SE   Manual
#=GF GA   31.40 31.40;
#=GF TC   34.60 119.60;
#=GF NC   20.70 26.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   23157252
#=GF RT   Tetarimycin A, an MRSA-active antibiotic identified through
#=GF RT   induced expression of environmental DNA gene clusters.
#=GF RA   Kallifidas D, Kang HS, Brady SF;
#=GF RL   J Am Chem Soc. 2012;134:19552-19555.
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents a member of a biosynthetic gene cluster
#=GF CC   (BGC). This BGC (BGC0000274) is described by MIBiG as an example
#=GF CC   of the following biosynthetic class, polyketide, in particular
#=GF CC   the  tetarimycin A biosynthetic gene cluster from uncultured
#=GF CC   bacterium [1].
#=GF SQ   42
#=GS A0A1C5BDW9_9ACTN/6-238   AC A0A1C5BDW9.1
#=GS A0A1C6PUN6_9ACTN/6-238   AC A0A1C6PUN6.1
#=GS A0A371Q3H7_STRIH/9-245   AC A0A371Q3H7.1
#=GS A0A4U0NK95_9ACTN/1-228   AC A0A4U0NK95.1
#=GS A0A371PVI7_STRIH/6-245   AC A0A371PVI7.1
#=GS A0A1D7VMH3_9ACTN/46-285  AC A0A1D7VMH3.1
#=GS A0A1D7VRB7_9ACTN/9-242   AC A0A1D7VRB7.1
#=GS B5H843_STRE2/29-265      AC B5H843.1
#=GS A0A286PG37_STROL/1-236   AC A0A286PG37.1
#=GS A0A0P4R2W2_9ACTN/6-238   AC A0A0P4R2W2.1
#=GS A0A0X3V1M1_9ACTN/2-233   AC A0A0X3V1M1.1
#=GS A0A1D7VVJ3_9ACTN/1-240   AC A0A1D7VVJ3.1
#=GS A0A2A2Z9V5_9ACTN/2-238   AC A0A2A2Z9V5.1
#=GS A0A0F0HSC6_9PSEU/6-244   AC A0A0F0HSC6.1
#=GS A0A0N0H1N3_9ACTN/1-220   AC A0A0N0H1N3.1
#=GS A0A7L4Y521_9ACTN/6-239   AC A0A7L4Y521.1
#=GS A0A0N1GU08_9ACTN/2-227   AC A0A0N1GU08.1
#=GS A0A1D7VMG8_9ACTN/6-237   AC A0A1D7VMG8.1
#=GS A0A0X3V2C6_9ACTN/2-234   AC A0A0X3V2C6.1
#=GS V6K4A6_STRNV/6-238       AC V6K4A6.1
#=GS A0A1G6RDX7_9PSEU/14-248  AC A0A1G6RDX7.1
#=GS A0A1H8R0P2_9PSEU/1-233   AC A0A1H8R0P2.1
#=GS A0A371PW13_STRIH/6-239   AC A0A371PW13.1
#=GS A0A1P8Y0J2_9ACTN/6-239   AC A0A1P8Y0J2.1
#=GS A0A2D3UBX4_STRC0/9-244   AC A0A2D3UBX4.1
#=GS A0A1G9V8C4_9ACTN/6-239   AC A0A1G9V8C4.1
#=GS A0A1Q5G6F0_9ACTN/1-225   AC A0A1Q5G6F0.1
#=GS A0A2N5X4Z2_9ACTN/1-234   AC A0A2N5X4Z2.1
#=GS A0A558CPE6_9PSEU/1-125   AC A0A558CPE6.1
#=GS A0A0P4R8I4_9ACTN/12-255  AC A0A0P4R8I4.1
#=GS A0A4V2P3B7_9ACTN/2-236   AC A0A4V2P3B7.1
#=GS A0A0Q8PUJ0_9ACTN/1-220   AC A0A0Q8PUJ0.1
#=GS A0A4U0NJA9_9ACTN/6-245   AC A0A4U0NJA9.1
#=GS A0A0P4RC93_9ACTN/1-228   AC A0A0P4RC93.1
#=GS A0A4U0NFJ9_9ACTN/21-265  AC A0A4U0NFJ9.1
#=GS A0A0P4RGM2_9ACTN/6-239   AC A0A0P4RGM2.1
#=GS A0A2P2GVL9_9ACTN/19-252  AC A0A2P2GVL9.1
#=GS A0A4U0NJD0_9ACTN/1-193   AC A0A4U0NJD0.1
#=GS A0A4Z0H7N2_9ACTN/6-245   AC A0A4Z0H7N2.1
#=GS A0A0X3VMH3_9ACTN/6-245   AC A0A0X3VMH3.1
#=GS A0A563EQQ7_9PSEU/16-169  AC A0A563EQQ7.1
#=GS A0A059W159_STRA9/5-247   AC A0A059W159.1
A0A1C5BDW9_9ACTN/6-238              ..............FWECPPEQG..IAQ-.HGEFRLTLIEPPFLTG.......GGVLP....AHDPARAWEFAAALGTVDTVMEEVDRIEATERLPFATRADLDLVGVGCWGTVTEINDPALVS.TGGTFPLAEQADELAERFPGAVIIGSARIDH...NVTYGTHVIHHPDGASLFAAG.WSGEE.D...WDREGTPQDVIGAFGIAPDALER.RG...I......DLD....A.APGS..FSWEGLTRLAL...QRVT.PLLR.KGRTLSVFRVRHTEEATGDLEDTWIG-e.
A0A1C6PUN6_9ACTN/6-238              ..............HWTSAPDRV..VRGS.MGLCHLTVFEPPFAVD.......ALDLP....PQDGARARAFAESTAGIEEVLEDLGPRSVQTPLPSDVRTDLDVAHGAAWGNMLSIADPAYAA.DGNDEPLRSAADELRERFPDARIVGRVAYHG...GMEHTEDLVWLPDGAMFHASG.WYGDE.P...FVVTGDPGAVIASLDLKGWMHDN.AG...V......DLD....E.EANE..VEWARLAGLAL...GHSD.PWGW.EQMQTTAFRVRHSEEAVRNMEELYF--v.
A0A371Q3H7_STRIH/9-245              ........kpdkga------DEV..LPKW.GSHAVLTLHFPPFPDPda...sgDPALA....PHDPVRARQVVEELGTVGEVLEQLPERPIGDVPDPEVRADLELVAVGCWGNVVHIVEPALGS.DLLTEAMTEEIRRQRERHPQARIVGSLEIDY...GNSYCEDVVDLPGGEKAYAGG.WDCDD.D...WEFLGDAEEVLRAIGVDRGPAAE.AG...F......DLD....E.EPRD..RVWSDLGTLAI..wGLHS.GAG-.-GRQVSVFRVRRTEEAAFHLEEVWFG-r.
A0A4U0NK95_9ACTN/1-228              .............m---------..VHGS.MAHCNLTVLQPPFTID.......VADFP....ANNPALAAKFACSLSTVDAVMEDLGQHPGSSGPNFQTRADLDIVQAGVWGGVLFASDPAWVD.NGNDDPLLYEAKGLRERFPDARIVGRASAHC...GAEHTEDLVWLPDGTMFHASG.WPGDE.P...FDVTGDPEAVLSSLGITRDMLDD.MDa.yV......DLD....D.EPNE..IDWWALVALAL...GEAD.PWGI.AGLNMSSLRVRHTEGATSHMGKLYF--it
A0A371PVI7_STRIH/6-245              ..............FWTHPPETA..VRSSnSDEYIITLLDPPLPES.......TAELS....PHDHGRARAFVEAFPTVDAVLEELPPMPASEALHAETLSDLGLITIGCWGNVTCISDPALATyDAGMTPVLNEVTALHERYPSALIVGSAAPDF...GETHTEDVICLPDGLTLFASG.FPAYEtP...WHVDGDPHTILNALGIDLADLTD.EDredL......YLD....E.EPHL..TNWGALGGLVL...EHCG.RRLR.NGLEMSVFRVRHTEDYTSMMEEMWMW-t.
A0A1D7VMH3_9ACTN/46-285             ..............FWTLPAETA..VRSShSGEYALTVLDPPLPGS.......TAELP....PHDRARARAFAEAFPTVDAVLEELPPLPASEALYAETLSDLDLITVGCWGNVTCISDPALAAyDAGMTPVLQEVTTLHERYPEALIVGSAAPDF...GETHTEDVICLPEGLTLFASG.FPAYAtP...WDVDGDPHAILNALDIDLAGLTD.DEreyL......QLD....A.APHL..TNWGLLGGLVL...EHCG.RKLR.TGLETSVFRVRHTEEYTSAMEEMWGW-t.
A0A1D7VRB7_9ACTN/9-242              ..............FWTRPSDRM..VRGC.GGRYNITVLQPPFAVR.......AEDLP....ANDPVAARAFAEAFPTVDAVLEELDPVSAYATPYLATRADLDVIQVGCWGNVLAISDPAMVD.DGNDTPLLYEVTRLRERFPDARIVGRVEVDC...GESHTEDIIQLPGGPMFHASG.WPTMD.P...WALTGDPRAVAAALGIGADVLEE.HE...I......DFD....A.DPGD..VEWADFATLAL...GEAD.PWPM.AGLKTSVFRVRHTESSTRKMEELFF--ig
B5H843_STRE2/29-265                 ..............FWTCLPQAQ..VRG-.SGEYTVTVVLPPFPDQ.......SGDWP....PNDPERAREFAASFGTVDAVLDYHGEQNISDGFSLTTRDDLDWIQVGVWGNVIGISDPALAD.DGNSWPVLEQVRNLAERFPGAKIIGSATVDR...GETHEEAAWVVPGVEPVHSEG.WPVED.DpsrWTLEGDPQAVLDACGVTPQMAKE.AD...V......AYD...pD.DPTS..TYWGGLGELIL...GVHR.PWRR.RKVRTSVFRVRHTHDATDLMEEVWIS-d.
A0A286PG37_STROL/1-236              ........mspvsp------GTQ..VNPRhSGHAHLVIVHPPFAAPlq..pneRPSAI....AHDPAAARAAVLSLSTVSVIRGEYAPSRLEHPGSPTSREELDGVRAAVWGSTVKISDPALVEdGVLTSALENEFQAQRKKHPDARIVALCERDF...GASYTKILVAVPGTPDLMVEG.FD---.D...LEITGDPRATLAAAGIALERLGE.-G...Y......DIS....D.EGFF..DYDGFLHMLTG...GALS.VYAD.EERFESAFVVDRSEEGEDSICEVWF--p.
A0A0P4R2W2_9ACTN/6-238              .............y-WTSAPDRI..VRGS.MGLCHLTVAQPPFTID.......ARSLP....ANDSDQARLFVESFGGIEEVLEDLGPRSVQTPLPSSVRSDLDIVHAAVWGGMRAISTPAFAD.DGNGNPLLAEAERMRERFPAARIVGHVTYYG...GMEHTETVVILPDGAMFHASG.WPDDE.P...FVVLGDPHAVTASLGLSSWMLTA.AD...I......DLD....Q.PHHE..IEWASLAGLAL...GHSD.PWGW.EEMQTTAFRVQHSDLSVCSMEGLYF--i.
A0A0X3V1M1_9ACTN/2-233              .........alwrg---------..----.-ADITLSLLFPPFPDAag...tvRPALP....PLDPVRARAFAEQLSTVEEVLEELPASSVWDIPSPEVRADLDLIAVGCWGGLVQIFDPALGS.DLLSDAMSNEIAELRARHPQARLVGSVSLDY...GNSYLEHEVVLPTGEHLFAGG.WDCDG.De.gWVYRGDPDEVLRAMGADRETAAE.AG...F......EPD....G.EPCE..REYGALGTVAL...GLHR.PGEGfEARRVSVFRVRRTSRGCFNLREVWFG-r.
A0A1D7VVJ3_9ACTN/1-240              ...........msp---LPHDDRaaVTAPgLSVTRITRIHPPAPARyd..rhtVTRAP....AHDPVRARQVVNALSTVASVVDECAPVRRRDLGHPRVLEDLDRVTVGCWGSVVQITDPAFGEdGISSCNLDDAFDQQVEDHPDARITGVCEMGF...SETYAKYLVHVPGVPRVAADG.WE---.D...MDLTGDPVETLRAVGVTPGGTGS.AD...V......SLD....D.LEGF..VWSAYLDVLAC...GLHV.PFVN.EQLRVSVFKVTRPADVRDAIEDVWHQ-h.
A0A2A2Z9V5_9ACTN/2-238              .......seapdhr---------..----.-GFAHLVVVHPPFAAPvlp.dqrPSAAP....AHDPEAARTAVLGLSTVSAVRRERAPSRLALPKSPVRRKDLDEVSVAVWGSTVKITDPALVEdGMQPDALEDEFRAQKKKYPEALVVAVCSLNF...RFHYTKLLAAAPNIPDVKIEGrWV---.-...LQTTGEPRAVLAAAGVDLDELDA.EYgdeFa...peCGD....D.GGGL..SDFDGFLHMLT..gGALG.VYAD.EERVHSTFVVKRSKHGKDCLRRIWL--p.
A0A0F0HSC6_9PSEU/6-244              ..............HWDLPPDRE..VDG-.FAECTLTLVLPPFAPHsratrtsVDGFA....PHDPTRARAFVESFPTVEAVLDELPPTDAG-PEHPGDRADLDLVRVGCWGNVIAMADFAITD.FGDFGALLDTTTALAERFPDARIIGSASLDG...GAHHVETVVHLPGGLRLYSEG.WADGD.R...YDLDGDPHAIARAVGIAPEVLAA.RD...F......DLD....G.APWS..VGWTAFGHFLL...EPYD.PWGY.KALRMSHFRVRHTEDATLRMEDVWFR-d.
A0A0N0H1N3_9ACTN/1-220              ...........mgl---------..----.---CHLTVAQPPFTVD.......ARSLP....ANDSDQAHLFVESFDGIEEVLEDLGPRSVQTPLPSSVRADLDIVHAAVWGGMRAISTPVFAD.DGNGNPLLAEAERMRERFPTARIVGHVTYYG...GMEHTETVVMLPDGAMFHASG.WPDAE.P...FVVLGAPHAVIASLGLRSWMLTA.AD...I......DMD....Q.PLHE..IEWASLAGLAL...GHSD.PWGW.EEMQTTAFRVQHSDLSVCSMEGLYF--i.
A0A7L4Y521_9ACTN/6-239              ..............FWTSPADRI..VRGS.MGHCNLTVLQAPYDVD.......GRALP....ANDPVRAAEFAASCDTVEEILEDLGARSALETPYPDRRSDLDVVQAGAWGHVLGICDPAFAD.NGNDTPLLHGAKVLRERFPDARVVGRVHFHA...GADHTEDLVWLPDGAMFHASG.WPGDE.P...FVVSGDPDAVIASLGLTGETLEG.AG...L......YLD....EdEPNE..TEWSALATLAL...GQAD.PWNR.PDVQTSAFRVRHTESAVRAMEHLYF--i.
A0A0N1GU08_9ACTN/2-227              ..........dprc---------..----.NGHAQLVVLQPPFAVPlq..rheRPGVV....VHDPGAARDAVLALSTVSAIRRECAPDLLDHPGSPADRGELDHVRAAAWGSTVKISDPALVEdGILASALEDEFRVWKKRYPDARIVAVCQRDF...GAAYLKLLVAVPGVDDLVVEG.FD---.E...LEIVGDRRATLAAVGIDPLPLGE.ED...-......DVS....G.-EGF..FDYDGLLHMLT..gGALS.VYAN.EERFESAFVVERSAEGEDSIREIWF--p.
A0A1D7VMG8_9ACTN/6-237              ..............IWDRPPEAP..VLR-.TGAFRLTMIERPFPGP.......AGSLP....AHDHARARDIAAGLTTVEEITAELEPRPDSDGLPHETRADLEQLDVGCWGPVTEITDAAFAH.RGEFTPLADHAEALAKRYPNAALIGSVTVDF...AIRYRAFLFLHPDGTQLWADG.WAGED.P...WTVTGNVHHIIDAFAVR-GALEN.AG...F......NAA....A.EPGV..MAWSELEDVIL...RSLM.PVRR.SERMLSGFRVTRPREVAVHLEETWLE-e.
A0A0X3V2C6_9ACTN/2-234              .........aalpy---------..----.SSAIRITRVHPPVPAGyd..rrtIAQAP....AHDPVRARRVVSELSTVAGVVEECEPMRRLDVGSPRTVADLDRVTVGCWGGAVQITDPAFGEdGITTRNLDSAFDAQVTDHPDARVIGVCEMDF...SMSYVKYLLHVPGVPPVRADG.WDGTDgG...MDLTGDPVRVLHAIGVPPGDPGN.SP...V......SLD....D.LERF..LWSDYVDVASC...GLNQ.PFAD.ESLMVSVFRVRRSEDIRDAMDEVWHR-a.
V6K4A6_STRNV/6-238                  .............y-WTSAPDRM..VRGS.MGLCHLTVFQAPFNVD.......ARSLP....RQNPAQARAFAESFEGIEEVLEDLGPCSVLTPLPSHVRADLDIVHAAAWGGMLSIVNPAFAA.DGNDEPLRSAAEGLRERFPDARIVGRVAYHG...GMDHTEDIVWLPDGAMFHASG.WPGDE.P...FVVSGDPQAVIASLELKGWQLDN.AG...V......DLR....E.AANE..VEWARLAGLAL...GPSD.PWGW.EEMEGTAFRVRHAEDAVRDMENLYF--v.
A0A1G6RDX7_9PSEU/14-248             .............y-WSSPRDRT..VSGS.LGLCHMSVFEPPFNVD.......ARNYP....PQDPVRSRAFAESLDTVEQVLDELGPRCVLTPLPSAVRADLDVVHVAAWGSMVGIADPVFAA.AS-GGPLKAVAAQLRERYPAARIVGRVTYYSpaeDTEDTEDLVWLPDGAMFHAAG.RSGVE.P...FAVIGDPDAVIASLGLAGWMLDN.AG...V......DLA....E.KASE..VEWARLAGLAL...GHSD.PWGW.EQMETTALRVRHSEAAVRSMEHRYF--g.
A0A1H8R0P2_9PSEU/1-233              ............mi-----DDQE..VNG-.YGESTIAVVLPPFPPHar...ssPAGFA....PHDPVRARAFAESFPTIEAVLEGLPDTSAV-PASPQTRADLDLVAVGCWGGVIGISDPALAG.DSFDKALWDVTSALAERHPEARIIGSASIDR...GENHSQTAIHLPGGLKLYTEG.WPGPE.Q...FSIEGDPHAIARAVGISAEALAA.AY...I......DLD....D.EPWT..VPWGHFGRQLL...DPCD.PWGH.AGLRMSEFRVRRTEDAALHLAEIWLS-v.
A0A371PW13_STRIH/6-239              ..............FWTCPPDQE..VRGH.SEDHTLTLLLPPFPTG.......TVNLP....PHDPVRARHFAENLDTVDEILEELPPGSAGHHLALETRADLDIIKVGCWGNLISISDPALAE.SMGDLPLLGASTTLRERYPDARIVGSAHVDC...GEDHTEDIIQLPGGVMLHAEG.WPCVE.P...LDVTGDPQAVVRALGISPETLAE.AE...I......DLD....A.ASDE..NDWQALGRLAL...GPCD.PWGR.PDLQMSVFRVRHTSSATFRMRETWFL-n.
A0A1P8Y0J2_9ACTN/6-239              .............l-WDHPSDEP..VER-.HGEFTLTVVHPPFPGP.......DGVLG....AHDEARARTFAEAFGTVHQVLDQQGTIPVTEFIDVDTRADLEVIRVGCWGGVTEINDPALIS.LSERFPVQEQAEALADRHPDAVIVAAAEMDL..pGADYGTWKIVHPDGARIFAAG.FSGEE.D...WDVEGEVTAVLDAFGITPERAAA.VG...V......DPA....Q.PPRS..FAWDTLARLAL...KAVS.PTDR.RGLMASVFRVRHTEDAVVAMEDTWFE-r.
A0A2D3UBX4_STRC0/9-244              ..............FWTLPPDRI..THGS.GSRYELTVVQPPFTVD.......AADLP....PNDPERAAEFARCLDTIDDVIEDLGPRKQSDTITVATRADLDLVQAGAWGNLLSISDPAFAD.DGNDMPILAEATRLRERFPDARIVGRVEVHC...GAEHTEDLVWLPDGTMFHACG.WPGDE.P...FVVTGDPQAVMSALGITTEVLED.LD...Vy....fDLD....D.EPNQ..NDWGALATACL...AGAD.PWGR.ADLDASSLRVRHSEHATSHMEALYFS-g.
A0A1G9V8C4_9ACTN/6-239              ..............FWTCPPDRE..VQGR.GDDCTLTLLLPPFPTG.......TVDFS....PHNPAEARHFAENFATVDEILEELPPISAAASPALWTRADLDIIKVGCWGNVISITDPALAD.NIGDLPLLGASTKLRERHPDARIVGSANVDC...GEDHTEDIIQLPGGLMVHTEG.WPGVE.P...LDVTGDPRAVVRALGISSETLAD.EA...I......DLD....E.ESDE..IDWRALGRLAL...GPCD.PWGR.PDLTMSVFRVRHTSGSTYRMEESWFW-n.
A0A1Q5G6F0_9ACTN/1-225              .............m---------..----.-GHCDLTVLQPPFDADpl...tcTRALA....ANDPLRAAEFAASFGTVEAILEDLGPRSSLDVPHPDRRADLDVVQAGAWGHVLGICDPALAD.NGNDTPLLYEAQALRERFPDARVVGRVHFHA...GADHTEDIVWLPDGAMFHASG.WPGDE.P...FVIGGDPDAVISSLGLTTEVLEN.AG...L......YLD....EdEPNE..TEWSALATLAL...GPAD.PWNR.PDVQTQAFRVGHTGSAVRAMEHLYF--i.
A0A2N5X4Z2_9ACTN/1-234              .......mstepri---------..--AWrQSTLRIIRVHPPYGAPyd..qhtVRRAP....AHDPVRARAVVAGLPTVATVAEELGPVLRRHTGHPQDIGDLDHVTVGCWGDVVQICDPAFGEdGILSTNLDDAFDAQVEAHPEARITAVCEMYS...FESYGKYLAHVPGQPRLSADG.WH---.D...QYVTGDPAQLLRAVGVDPRTSGV.EY...L......GTG....E.DDPF..VGTEYLDLLAR...GLHS.VYSK.ENLAVSVFRVTRTEDVRDSLADVWLR-k.
A0A558CPE6_9PSEU/1-125              .............m---------..----.----------------.......-----....--------------------------------------------------------------.--------------RERYPDARIVGRVEADR...GESHTEDIVWLPDGTLFHASG.WPGMD.P...WELTGDPHAVAAALGITDRTLED.LD...I......DLD....A.EPDE..VEWADFVSLAL...GEAD.PWPL.SRPQVSAFRVRHTRPCTRRMERLFL--pg
A0A0P4R8I4_9ACTN/12-255             .......awvdhpd--------L..VRAWrGSTTLLTLSFPPFRDPaa...aaV---PwtpkPHDPIRARRVVESLGTVDAVLEELPVRRTADLEEPEMRADLDYVAVGCWGDLVWISDPALGD.YGMGCGMDGEIGVQRALHPEARIVGTMSMDY...GLTYCQHAVDLPGGRRLDVSG.WIDAE.G...LEVTGDPEDLLRVIGIDPATVRN.TY...T......DPD....E.PDNIdwCDWDRYTDFFVggfADID.WSTQ.QDLRASLFRVRRSESAQGDLAEVWLG-k.
A0A4V2P3B7_9ACTN/2-236              ......spvspgtr---------..VNPGhSGHAHLVIVHPPFAAPll..pgeRPSAA....AHDPGAARAAVLSLSTVSMIRREHAPSRLEHPGSPAGREELDGVCAAVWGSTVKISDPALVEdGVLAGALEDEFQAQRKRHPDARIVAVCERDF...GASYMKILVAVPGTPDLTVEG.FD---.E...LEITGDRRATLAAVGIDPDRLGE.G-...Y......DVS....D.-EWF..FDYDGFLHMLT..gGALS.VYAD.EERFESAFVVDRSEEGEDNICEVWF--p.
A0A0Q8PUJ0_9ACTN/1-220              ...........msl---------..----.---CHLTVFEAPFNVD.......ARNLP....PNDPERARAFVESFEGIEAVLEDLGPRSAQTPLPSAARSDLDIVHAAAWGGMLSIVTPAFAT.DGNDEPLRSAAKELRERFPDARIVGRVSYHG...GMEHTENIVWLPDGAMFHASG.WPGDE.P...FVISGDPRAVIASLDLRGWMVDN.AG...V......DLD....E.PANE..VYWAGLGGLAL...GHSD.PWGW.EEMETTAFRVRHSEDAVRDMESLYF--v.
A0A4U0NJA9_9ACTN/6-245              ..............FWTCPPETT..VRSSnSEEYIITLVDPPLPGS.......TAELP....PHDHVRARTFVEAFPTVDAVLEELPPMPASEVLFAEELSDLDLITVGCWGAVTCISDPALATyDAGMTPVLHEVTALRERHPSALIVGSAAPDF...GETHTEDVICLPDGLMLSASG.FPAYEsP...WYVDGDPHTVLNALGIDLADLTD.EDreyL......YLD....G.KPHV..TNWGMLGGLVL...DHCG.RRLR.KGLEMSVFRVRHTEDYTSMMEEMWMW-t.
A0A0P4RC93_9ACTN/1-228              ...........mtt---------..--GS.GTRYELTVLQPPFTVH.......AAGLP....PNDPARAAAFARSLDAVDEVIEDLGPRKQSATHTVTTRADLDVVRAGAWGNLMSVSDPAFAD.DGNDMPLLAEATRLRRRFPDARIVGRVEVHC...GAEHTEDLVWLPDGTMFHACG.WPGDE.P...FVVAGDPRAVMAALGVTAEVLDD.LE...Vy....fDLD....D.EPNQ..NDWGALATACL...GDAD.PWGR.PDLDASTLRVRRSEHATRHMESLYF--it
A0A4U0NFJ9_9ACTN/21-265             .........awvdh----P-D-R..VRPWrGSTTELMLYFPPFPEPgt..sagPPVLE....PHDPVRARRIVETLGTVDEVLEQLPDRRREDLAEPEERAELAYVAVGCWGNYVWISDPALGD.YGMGCGMDPEVERQRELNPQARIVGTMHMDY...ALNYYQDVVVLPGGQRLDASG.WGDAD.P..gIEVYGDPEEVLRAAGFDPASVTD.RY...I......DPEe..pD.DPGC..AYWSSYTDLFLggfGDIE.WHVR.DELTVSFFRVRRSERAESDLEEVWL--gp
A0A0P4RGM2_9ACTN/6-239              ..............FWTSPPDRM..TRGS.GCRYNITVVQPPFEVR.......AEDLP....PHDPAAARAFAETFPTVDAVLEELEPVAACANPYLATRADLDVIQVGCWGNVTAISDPAMAD.NGNDTPLWYEVNRLHERFPEARIVGRVEVDC...GESHTEDIIRLPGGPVFHASG.WPTMD.P...WELTGDPRAVAAALGIGADVLQE.HD...L......DFD....A.DPGD..VEWADFATLAL...GEAD.PWPM.SSLTTSVFRVRHTESATRTMEELYF--lg
A0A2P2GVL9_9ACTN/19-252             .........vagmt-----DDTP..VDK-.WGHYELLLLFPPFTRD......aGPEAP....PHDPEWARRVVESLGTVAEVLEELPSRGLDRLPAPETRAGLDVVAVGCWGGTVLVVDPALAG.DAVVAAMAEEVDRQRALHPEARIAGSVRLDA...GEEYREFLLDLPGGPALRVGG.WGDDE.E...WTVSGDPAGQLRALGVDPDGHGD.AD...V......DLA....E.EPRY..VDWDAYGLLAL..gRQVT.DGDR.SRLRPSLFRVRRTQRAAADLNDVWF--g.
A0A4U0NJD0_9ACTN/1-193              ............ms---------..----.----------------.......-----....------------------TIVREDAPSRLEHPGHAASREELDWVWASAWGSTVKISDPALVD.NGISSALEDEFEAQKTKYPDARIIAVCERDF...GASYAKVLVAVPGAPDLTIDG.WD--E.L...EVIGGDRRATLAAMGIDADRSGEgHD...VadeaddEADgeehD.EEDF..DYHGFLHVLTG...GALS.VYAG.EKRSESAFAVERSKEGEGNIYEVWF--pe
A0A4Z0H7N2_9ACTN/6-245              .............y-WTCPPETD..VRRTyFGEYAITLLDPSLTGG.......TITSA....PHDPARAREFVEGFPTVEAVVEELPPLPPSELLATECRSDLDLVTVGCWGSAICVSDPALTAyDAGMTPVLDVATSLRERYPRALIVGSAHADF...GESHTEDVIWLPDGPRLFASG.FPCYEdP...WDIEGDPRAVLDALGVDPDGLEG.DYrefL......HLD....E.APHL..TNWGMLGALVL...ERAG.HRPG.ADLEMSVFRVRHTEEYTAVMEEMWL--pg
A0A0X3VMH3_9ACTN/6-245              ..............FWSCPPDKP..VRGSvSDEYHITLLDPPLPGS.......TTPLP....SHDPGRARAFAEAFPTVDAVLEELPPRSASDTLAVDIRSDLDLIAIGCWGHVTWISDPALAAyDAGMTPVLDEVTALHERYPRALIVGSAAPDF...GETHTEDVIRLPDGRTLFASG.FPAYEdP...WHVEGDPEAILEALGIDQADLTE.QDredL......RLG....E.EPHL..TNWGMLGGLVL...EHCG.RGFR.SGLEMSVFRVRHTEHYTAAMEEMWTW-a.
A0A563EQQ7_9PSEU/16-169             fgygggviddqevn---------..----.----------------.......-----....------------------------------------------------------------AD.DGLDCTLLTVTSALAERYPEARIVGAANIDR...GENHDETAVHLPGGLKLHTEG.WPAAG.Q...FYIDGDPHAVVSALGISAEVLAS.AY...I......DLG....E.EQWT..VPWEHFGRQLL...DPYN.PWGF.AELKMSLFRVRHTEEAMLHMEDIWLA-a.
A0A059W159_STRA9/5-247              ...........eae---HDPDEE..VQPWrHSEVTLTLLFPPFPDPdv...teREPLP....AHDPVRARRVVEELGTVAEVLEQLPERPVGDLAWPSVRADLDFVAVGCWGGVVMVFEPALGS.DLLCEAMTAEVARQRARHPEARIVGSVELDY...GNRYLEEQVLLPSGPEVFAGG.WDCDD.Ed.gWSFAGDPQEVLRAIGVDRETAAE.VG...F......DLD....D.APCD..RTWSDLGVLAL...GLHRrPAGGvEERHVSYFRVRRSQEGADNLAEVWFA-r.
#=GC seq_cons                       ....................pt...Vps...uchpLTllpPPFsss.......stshP....spDPsRARtFscuhsTV-tVLE-LsPpsstcshsspsRuDLDlVplGsWGssltIoDPAhus.sutsssLhspsptL+ERaP-ARIVGssphDh...GtsasEsllhLPsGshlaAsG.Wss.-.s...aslsGDPcAVlsAlGlsstsLss.ts...l......DLD....-.tssp..spWusLusLsL...Gtss.Past.pphphSsFRVR+oEcuspsME-lWa..h.
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