#=GF ID DUF6346
#=GF AC PF19873.3
#=GF DE Family of unknown function (DUF6346)
#=GF AU Williams LS;0000-0001-5551-8526
#=GF AU Finn RD;0000-0001-8626-2148
#=GF AU Fragoso S;0000-0001-7018-3891
#=GF SE Manual
#=GF GA 25.00 25.00;
#=GF TC 25.60 25.30;
#=GF NC 23.70 22.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP Family
#=GF WK Domain_of_unknown_function
#=GF RN [1]
#=GF RM 20690632
#=GF RT Fluostatins produced by the heterologous expression of a TAR
#=GF RT reassembled environmental DNA derived type II PKS gene cluster.
#=GF RA Feng Z, Kim JH, Brady SF;
#=GF RL J Am Chem Soc. 2010;132:11902-11903.
#=GF DR INTERPRO; IPR045927;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This entry represents a member of a biosynthetic gene cluster
#=GF CC (BGC). This BGC (BGC0000223) is described by MIBiG as an example
#=GF CC of the following biosynthetic class, polyketide, rabelomycin
#=GF CC biosynthetic gene cluster from uncultured bacterium BAC
#=GF CC AB649/1850 [1]. This family appears to be predominantly found
#=GF CC in Actinobacteria.
#=GF SQ 81
#=GS A0A5Q3Q941_9PSEU/24-158 AC A0A5Q3Q941.1
#=GS A0A1I5UUR0_9PSEU/11-153 AC A0A1I5UUR0.1
#=GS A0A2R4FHY5_9ACTN/3-152 AC A0A2R4FHY5.1
#=GS A0A344LI99_9PSEU/4-144 AC A0A344LI99.1
#=GS A0A263D530_9PSEU/19-156 AC A0A263D530.1
#=GS U5VT07_9ACTN/47-146 AC U5VT07.1
#=GS A0A4V2ES22_9PSEU/70-204 AC A0A4V2ES22.1
#=GS A0A1W2FC02_9PSEU/18-121 AC A0A1W2FC02.1
#=GS A0A1W2ERL3_9PSEU/3-117 AC A0A1W2ERL3.1
#=GS A0A1W2FBW2_9PSEU/2-134 AC A0A1W2FBW2.1
#=GS H5XAL9_9PSEU/30-170 AC H5XAL9.1
#=GS A0A5Q3Q9R8_9PSEU/4-147 AC A0A5Q3Q9R8.1
#=GS A0A1Q9LPC4_9PSEU/7-149 AC A0A1Q9LPC4.1
#=GS G8SE53_ACTS5/42-181 AC G8SE53.1
#=GS A0A5N0V055_9PSEU/1-138 AC A0A5N0V055.1
#=GS C7MPR9_SACVD/1-107 AC C7MPR9.1
#=GS A0A839DV71_9PSEU/9-147 AC A0A839DV71.1
#=GS A0A318LGD2_9PSEU/1-128 AC A0A318LGD2.1
#=GS A0A7X0IKF1_9ACTN/24-169 AC A0A7X0IKF1.1
#=GS A0A1I6P5H5_9PSEU/12-148 AC A0A1I6P5H5.1
#=GS A0A1K0GR22_9ACTN/43-182 AC A0A1K0GR22.1
#=GS A0A1G9D2U2_9ACTN/1-152 AC A0A1G9D2U2.1
#=GS G8S255_ACTS5/1-137 AC G8S255.1
#=GS A0A542CTN0_AMYCI/1-136 AC A0A542CTN0.1
#=GS A0A419HFP2_9PSEU/2-78 AC A0A419HFP2.1
#=GS A0A1I2HPH4_9ACTN/45-182 AC A0A1I2HPH4.1
#=GS A0A222VPB7_9PSEU/47-182 AC A0A222VPB7.1
#=GS A0A1H2BGX0_9ACTN/17-149 AC A0A1H2BGX0.1
#=GS A0A263D3B7_9PSEU/23-147 AC A0A263D3B7.1
#=GS A0A562VCA0_9ACTN/6-141 AC A0A562VCA0.1
#=GS A0A8J3BWU0_9ACTN/46-185 AC A0A8J3BWU0.1
#=GS A0A3N1AWG5_9ACTN/41-187 AC A0A3N1AWG5.1
#=GS A0A8J3CJB0_9PSEU/6-146 AC A0A8J3CJB0.1
#=GS A0A0D0VZD2_9ACTN/14-160 AC A0A0D0VZD2.1
#=GS A0A1I6TVB6_9PSEU/12-155 AC A0A1I6TVB6.1
#=GS A0A1W2FUP6_9PSEU/3-134 AC A0A1W2FUP6.1
#=GS A0A1H0BDI4_ALLAB/21-167 AC A0A1H0BDI4.1
#=GS A0A4V2EM92_9PSEU/18-163 AC A0A4V2EM92.1
#=GS A0A368VHR6_9ACTN/1-150 AC A0A368VHR6.1
#=GS A0A2R4FSV1_9ACTN/44-181 AC A0A2R4FSV1.1
#=GS A0A562V4C8_9ACTN/34-179 AC A0A562V4C8.1
#=GS C4RFN6_MICS3/96-241 AC C4RFN6.1
#=GS A0A4Q7KQJ0_9PSEU/39-194 AC A0A4Q7KQJ0.1
#=GS A0A1K0FF49_9ACTN/45-182 AC A0A1K0FF49.1
#=GS A0A4Q7ZCV1_9ACTN/46-184 AC A0A4Q7ZCV1.1
#=GS A0A841FKC8_9ACTN/532-676 AC A0A841FKC8.1
#=GS A0A7W9LZD6_9PSEU/1-143 AC A0A7W9LZD6.1
#=GS A0A1Q8CPM0_9PSEU/1-137 AC A0A1Q8CPM0.1
#=GS A0A344LF67_9PSEU/22-169 AC A0A344LF67.1
#=GS A0A7Z1B0Q5_9PSEU/1-134 AC A0A7Z1B0Q5.1
#=GS A0A344LF69_9PSEU/17-162 AC A0A344LF69.1
#=GS A0A318LYH3_9PSEU/23-153 AC A0A318LYH3.1
#=GS A0A563EYB8_9PSEU/3-134 AC A0A563EYB8.1
#=GS A0A4Q7JEW2_9PSEU/32-159 AC A0A4Q7JEW2.1
#=GS A0A0A6UBJ1_ACTUT/2-139 AC A0A0A6UBJ1.1
#=GS A0A2V4B310_9PSEU/7-149 AC A0A2V4B310.1
#=GS H5X4G0_9PSEU/8-170 AC H5X4G0.1
#=GS A0A8J3C2N4_9ACTN/17-163 AC A0A8J3C2N4.1
#=GS A0A2T0GU94_ACTMO/3-155 AC A0A2T0GU94.1
#=GS A0A7W7GUU2_9ACTN/45-183 AC A0A7W7GUU2.1
#=GS A0A263D3P7_9PSEU/1-128 AC A0A263D3P7.1
#=GS A0A7W5AHU4_9ACTN/45-182 AC A0A7W5AHU4.1
#=GS A0A1W2FCN9_9PSEU/1-153 AC A0A1W2FCN9.1
#=GS D3PVX1_STANL/3-143 AC D3PVX1.1
#=GS A0A1H3APQ7_9PSEU/16-153 AC A0A1H3APQ7.1
#=GS A0A1W2FSP0_KIBAR/8-144 AC A0A1W2FSP0.1
#=GS A0A239D2I2_9ACTN/1-141 AC A0A239D2I2.1
#=GS A0A543B0Q3_9ACTN/3-142 AC A0A543B0Q3.1
#=GS A0A327ZJD0_9ACTN/39-176 AC A0A327ZJD0.1
#=GS A0A839E518_9PSEU/6-151 AC A0A839E518.1
#=GS A4FM92_SACEN/10-147 AC A4FM92.1
#=GS A0A4R6SDJ7_LABRH/73-210 AC A0A4R6SDJ7.1
#=GS A0A344LF74_9PSEU/18-155 AC A0A344LF74.1
#=GS A0A255ELQ4_9ACTN/13-91 AC A0A255ELQ4.1
#=GS A0A0A6UQL2_ACTUT/52-189 AC A0A0A6UQL2.1
#=GS A0A1W2FGJ6_9PSEU/1-139 AC A0A1W2FGJ6.1
#=GS A0A3N1AVV4_9ACTN/4-150 AC A0A3N1AVV4.1
#=GS A0A1G9D2Y8_9ACTN/2-156 AC A0A1G9D2Y8.1
#=GS A0A3N2NYI1_9ACTN/51-188 AC A0A3N2NYI1.1
#=GS A0A840NEE8_9PSEU/26-165 AC A0A840NEE8.1
#=GS A0A563ET08_9PSEU/10-146 AC A0A563ET08.1
A0A5Q3Q941_9PSEU/24-158 ..............ra--GRVTHVLTQVFV..RVLLAL.....IIMT.V.LS.G...T....AM.TS.....ID..GSVRRVG.T.ATAVDCTRIGPVST.....S.......G.......L..GWWWQ.CDGVITWED....GA.....REQHRFN..GFMLTPADI.TQPVAV...-EYRD.GNGM-------......---..---.------...------------------sgavslrdapygafgyalfvplvalwllg..............
A0A1I5UUR0_9PSEU/11-153 ...............l-ARRVGRALIWLLA..LVVGLL.....AWAT.V.AR.V...T....YG.GG.....--..PEVDRLG.T.AQVLRCVEHGPVSR.....F.......G.......V..GTTHT.CTAEVRWSN....GQ.....VEQREFS..PGQLSPADT.GAAVPV..yLDIPE.GVRGELSLGRN......DSA..RFS.ALRLPA...NLLLGVVVAGLGLGAAY-t..........................................
A0A2R4FHY5_9ACTN/3-152 .............trg--QALLAAIVVYVV.gLVVCGM.....LLG-.V.RN.L...Y....AG.EP.....PR.vSGERVTG.T.AQVGACDRVGPVST.....A.......G.......L..GYWWD.CEVTVTLSD....GR.....TVSSVVG..PSIVTPEDR.DRPPTL..vGYCSR.TEPDDCSFTQE......GRN..LLL.GLLAWA...ATLLSLAVLAI-------tafvggtall.................................
A0A344LI99_9PSEU/4-144 ...............p-TRRLLKALAWCLA..LVLGLL.....AWST.V.AR.V...T....YG.GG.....--..PEADRLG.V.ATATTCTEHGPIGP.....R.......G.......F..GTSYT.CQAEVRWSD....GE.....TEHAEFP..AGQLEPGE-.-RDVPV..yLDTSE.SGRADTTLGRN......DTA..KYS.AVRLPA...VIGLGFLVVVLALGAGV-a..........................................
A0A263D530_9PSEU/19-156 ........fgigllfw---------VSFVS..LVLGTL.....AVGR.V.AG.Y...P....EV.GA.....VA..PTRGLDG.T.AVVTACRDDGPITI.....Y.......G.......L..GRAEV.CTADVSTPD....GD.....LGSVEFR..VGELTRADL.GRTVAV...--RPG.KEEWVRDVD-H......PYS..QLI.WPHLGL...LLMFLVQVG---------glstgvf....................................
U5VT07_9ACTN/47-146 ...............r-NKWLTNLFGIVIL..LALSFV.....LIAT.A.TT.V...G....RF.TG.....HD.fADARRTGtT.ATVEDCERRGPISL.....F.......G.......F..GYYDQ.CTVTIAWNG....SP.....SLRALID.kPGFFNGEAP.GIT---...-----.-----------......---..---.------...------------------fc.........................................
A0A4V2ES22_9PSEU/70-204 ............rdgv--------LFMLGV..GAASLV.....LTLT.V.FQ.S...A....EV.SS.....LG..AVQQRHG.V.LTVEQCDDPAPFGW.....R.......G.......I..GGQDS.CVGQVRWDG....GK.....IERVTAA..PGELSYSDL.RRPVAV...-----.-VEERGALGGS......SVV..RDD.GHAWAL...VGLPATIVLGLVALF---lltt.......................................
A0A1W2FC02_9PSEU/18-121 prgyaesiscarnwwa--------------..------.....----.-.--.-...-....--.--.....--..-------.-.--------------.....-.......-.......F..GALWH.CNATIVADD....GK.....QYPYSNK..NSSLTPADI.GNRVPM..tNNRVR.SGRSSQSSAEW......ALAerRDP.NKVAYM...LSLMGIPVVALFI-----tfrmf......................................
A0A1W2ERL3_9PSEU/3-117 ............avri----LHRIFAFLII..PVLGYL.....LGAT.I.FN.H...F....WN.KVe...tED.lSEASHII.-.-VATSCDRHGPVTL.....R.......G.......F..GYVYE.CRATVTNTV....NG.....NVVTATA..RGFLNPELI.GKQVA-...-----.-----------......---..---.------...------------------gtgfrrgdlyperpyag..........................
A0A1W2FBW2_9PSEU/2-134 .kmakriaiatvlwiv--------------..---ALY.....LAQA.A.PR.F...F....GG.EV.....-G..SGGETKG.Y.AEDISCSRN----W.....W.......A.......F..GVLWS.CDATIVAND....GK.....RYRYHDG..SSALTPADV.GQRVPM...T--NH.-----------......---..---.------...------------------rvrtsgssapsvewgvtelrepikalvalsivgipgvaf....
H5XAL9_9PSEU/30-170 ..........qllvql-----AVRVGVLLL..TLEFLL.....VAGP.S.IG.F...L....GG.DT.....--..--TGRSG.Q.AVVRSCEPAGVPSA.....V.......G.......L..SWYHS.CELRVRWPD....GG.....GETVPLD..TARLGADDV.GRTVAV...VEREG.GDKWGTVRQYV......ALA..GPS.PHAAPA...VIAFLSL-GMVALL----fpywy......................................
A0A5Q3Q9R8_9PSEU/4-147 ......thggsivrwv------------LM..LPVGVGiilctVWAV.G.FH.G...I....SV.YG.....--..ERVVDRG.V.AVAENCEFGGPFHA.....R.......G.......F..GMWST.CEAEVTWAD....GT.....VESREFL..RSQLTDADL.GRPVEV...-VERE.SFRGRGNAPDY......EVY..RAD.FLPSSA...WGYLLYAP----------iglggalclv.................................
A0A1Q9LPC4_9PSEU/7-149 .........prririg-------LISTTAA..LMMAAT.....IWPM.A.AV.M...E....RF.GI....dTN.pPNTTRTG.T.AEVSTCSDN--VGY.....-.......-.......L..WLTKT.CEARVTWSD....DR.....KVESKRV..---FAVRDIsGTTVDVrldEQSGK.RGGKGKNLYTA......DYP..HRQ.DSALVF...VLFMGFATGGLVLGGL--lg.........................................
G8SE53_ACTS5/42-181 ...............p-GSWLIEVAFVVIL..MVISAA.....LFGT.A.VT.I...S....RF.TG.....AD.iADARRTG.E.ATVEQCERDGPIGL.....S.......G.......F..GYVKA.CAVSIRWNG....GG.....GERVMIG.kPGFFTDEKP.GDTFTI...-----.-GENTGSRGSV......GYS..RAE.VPPRRW...VTALVTLISIIGVAPLLF...........................................
A0A5N0V055_9PSEU/1-138 ..............mr--SDLVRAVAWWAA..LVLTLL.....LFAT.V.SR.L...T....HG.GG.....--..PDVDRLG.V.ATVASCDEYGPVSQ.....Y.......G.......V..GTAYR.CTADVEWAD....GK.....TEQLVFP..AGHLTPGE-.-LDVPV..yADGGD.VGRNDVAWPS-......-VI..RLP.AVLVTG...LLALVAAVGAL-------yttyra.....................................
C7MPR9_SACVD/1-107 ...............m--------------..------.....----.-.--.-...-....--.--.....--..---ERVG.T.ASVVSCVEHGPIGL.....H.......G.......L..GTAYT.CTADVRWDD....GR.....TERRTFP..VGQLTPAVH.GMAVPV..yEDVAD.TRGDGTELGRN......DTA..AWS.QARVPL...LLVGGVVVLVLCMGA---lr.........................................
A0A839DV71_9PSEU/9-147 ..............ai---RLGKMLAGFLV..VVVLLL.....LNLT.I.VF.S...L....QA.GY.....--..--SETNA.I.AHVRSCENKGPISW.....R.......G.......F..GNNWN.CTAVFQQDG....TG.....GTWRATV.dFNLFTPEEI.GTPQRV...-LVSD.GGGRIVSSENV......EYH..QST.GISPGA...AGWIWTATTFVFIFPT--lw.........................................
A0A318LGD2_9PSEU/1-128 ...............m--------------..--LGLL.....VWAT.L.AR.I...T....DG.GG.....--..PEADLLG.T.AEVADCTEHGPVST.....Y.......G.......F..GTTYT.CSAEVRWSD....GT.....VEKREFP..AGQLSPADA.GTPVPV..yLDLGE.GYRSTTELGRN......GSA..RFA.DTGILV...TIAFGLLVVVLGVGALY-q..........................................
A0A7X0IKF1_9ACTN/24-169 ..........rrtdrv------EALAALAC..VLMFTAsl.alAFLT.G.NA.L...Y....RD.G-.....--..LAAERSG.Q.WVAARVLRDAPVPR.....T.......S.......I..DTVRTeLRTPVSWVD....TH.....NRQVIAD..APVFLGTKA.GTTVRV..wLDAKGrPGGTQPDR-AM......TVA..RAL.AGATGA...VTVAGGLLLGCFA-----lvrr.......................................
A0A1I6P5H5_9PSEU/12-148 ................RLTKMVLGLIVTAC..IVM---.....LWPT.I.VF.S...F....PE.KA.....--..--DEQNA.T.ATVQSCEDTGPITR.....R.......G.......F..GHNWD.CRVRITDDE....SR.....KNWTTNI.dMNFFSPEDV.GKEKRL...TWGHG.GGRASTNTDTY......VYT..RAE.-GYPAG...VRLLVSIVAAVVLLPPA-l..........................................
A0A1K0GR22_9ACTN/43-182 .........rpgrrrg--------WMVIAS..LLLASV.....VFAE.L.AL.T...V....QG.WS....sPD.fGEAGRIG.R.ATIVSCERQGPIGR.....-.......G.......I..GYWHR.CTADVVWDG....GF.....SGRYTFD.rRNFIHADEA.GTTITI...--GEN.GGARSTSV---......GYS..RPE.APYRPL...VAALGVSLAIVAAVPALL...........................................
A0A1G9D2U2_9ACTN/1-152 .........mrvvrdv------------LL..VPIGVL.....LFLA.A.FF.VvlpY....FG.TG.....AA.gAEVSARG.T.AVAQQCRFAGPIAK.....S.......SapkrenvI..GFGWI.CRARVHWND....GG.....VETREVS..GSQLTGDDV.GNRVDV..vERRID.YSKGSDTRP--......QIY..RAD.FEPQVL...LAWGSVLATC--------llgfvfaalgi................................
G8S255_ACTS5/1-137 .............mkq-------FLVSLAL..VVASVV.....LGLM.V.PT.V...A....RH.SQ.....AD.fDDAQRVG.T.GTVYLCTEYGPLTF.....A.......G.......F..GYTSK.CRVDVVWRD....GS.....KEMVNPN.rYGFADASEL.GRTITI...-----.-GDLGNG----......KYA..RPD.RPFRPL...IVVTAWLIALVAVAALL-lglagl.....................................
A0A542CTN0_AMYCI/1-136 ...............m------RAVVLVLL..LLAGLL.....ALAT.A.AR.V...T....HG.GA.....--..AEVDRLG.T.ATVAGCTEHGPVSV.....Y.......G.......I..GTTYR.CMAEVRWSD....GT.....TEQREFP..PGQLSPADT.G-PVPV..yLDLPD.HR-GEPYVGRN......DSA..WYS.TLRLPI...LLAVGGLVLVVGLVAG--ha.........................................
A0A419HFP2_9PSEU/2-78 .............wlr-------VAGRASL..LVLAAC.....CALT.A.LT.V...L....TL.AG.....RW..GSVTQTG.T.ATLTGCQRSGPITE.....H.......G.......W..GTMVS.CQAEVKADT....S-.....-------..---------.------...-----.-----------......---..---.------...------------------gdppda.....................................
A0A1I2HPH4_9ACTN/45-182 ................RPSRLRDTAFLAGI..VVLSLL.....LVGV.S.TT.L...I....GM.AG.....RD.fRDAQRTG.S.ATVESCDRRGPVTN.....R.......G.......L..GYRER.CTVTIGWDD....GT.....ATRLTDD..-GTFTSSDI.GSPVRV...-----.-GYLGTHRYTL......ELA..RED.TPHRPW...FTWIGGLVGLIAVVPGIF...........................................
A0A222VPB7_9PSEU/47-182 ...........rerfw------RVTYVVSQ..LAVRAL.....LALV.S.LT.I...A....AN.TGv..lsSD..GVVTKRG.S.ALATHCERVGPVSP.....S.......G.......L..GWYWA.CEAEITWSD....GE.....TAHERFQ..NSALTPENL.AHPKPVv.yQ----.-----------......---..---.------...------------------svrdaadqivvdeprpfvglgyslfvasvfaal..........
A0A1H2BGX0_9ACTN/17-149 .............rad---GRPSVRGLLVL..IVVGWL.....LFNA.G.TT.I...G....RF.TG.....PD.ySETTDRG.V.GTVEKCERRGPITL....fD.......G.......V..GYFDA.CYLWVEWDR....NA.....SERILVD.dPGFFQGEKP.GDTVRI...-----.---------GY......GVS..RPE.VSHWST...LDLLMYCFCGIGALLA--gl.........................................
A0A263D3B7_9PSEU/23-147 .......rlvavgvgl---------LLWASlaLLVLST.....LTVT.V.VS.A...Y....PS.AG.....AT.aPARGLDG.T.ASVTACRGH-----.....-.......-.......-..---DA.CTAQVSTPD....GD.....LGPVEFR..AGELTRADL.GGTVAV...-----.------RPDDG......EWV..RDV.AHPYGF...LFWLQLALLLVALSPLL-i..........................................
A0A562VCA0_9ACTN/6-141 ......adktpvllpi-----------LAG..VVLAVG.....GWTA.M.NF.R...G....GM.QG.....AD..LSDRAHA.T.AMVEHCEEVGPLGL.....S.......G.......V..GYWWR.CDVTIETES....GD.....RYDQVMG..GSHFTPDDV.GGSFPM...-----.-VNAGRFS--D......SWT..RAD.VPENGW...ATLA-TGVGLVGGA----illvfg.....................................
A0A8J3BWU0_9ACTN/46-185 ..............rp--ARRRGWLFLAAL..AIASFV.....LGEL.A.LT.V...Q....GW.TG.....PD.fADADRTG.Q.ATVVDCERHGPIGR.....-.......G.......F..GYWDE.CTADIVWNG....GF.....TERHTFD.rRNFLHADEV.GTTVTI...-----.GQGTGFRGGGV......TYS..RPE.LPHRPL...ITALGVILVVLAALPALL...........................................
A0A3N1AWG5_9ACTN/41-187 ................RLRLLFFAVVTLAV..AYVFSL.....IYLT.A.LS.F...Y....PG.TGv...iRP.yGPTERPV.Q.AAVEECRRIGPVSD.....H.......G.......L..GYWWV.CRISVEREG....GQ.....GAEAVVG..GSIANPGQI.GKVVTL..kEACHD.PDGTECGYGK-......SVP..RVL.ELLYGC...FQIFGRTVGAFFLVVAA-l..........................................
A0A8J3CJB0_9PSEU/6-146 ............lagr-------ALRMVLG..LCLALL.....VLLL.G.FT.L...S....TW.AG.....ET..ASNGKRG.S.ATVESCESEGPVST.....Q.......G.......L..GYWRR.CQVSVAWQD....GT.....RSEHSVS.sGQGFHDAPV.GSAIEV...RYA--.-----------......---..---.------...------------------rktssldryviqaegpswfrevivgkglgliggfvgagital.
A0A0D0VZD2_9ACTN/14-160 ................RLAKFGAAVACAVA..IVVSWL.....VFDT.M.TG.F...Y....SG.TGv...vKS..TPAERPA.Q.GTVGACRRVGPVSG.....D.......G.......F..GYWWH.CAVTVRTGD....GR.....EVRIVTR..NSAVTPADR.GGPVDF..rEACFG.KGNTDCRYGR-......PVS..RVW.ALAVTI...LGMARIGLTIVLILAV--gvy........................................
A0A1I6TVB6_9PSEU/12-155 ...............a-HVRLILAAVCLAI.gLFFGALgv.iaLVGS.G.AT.A...S....DV.DG.....--..-GKQRSG.T.AVPVKCWSDGPLFL.....-.......-.......-..NFWEK.CDLQVRWQD....GS.....TSTAVSV..ETDFSGDDV.GQRFPV..vQNLPD.GGHRPTTM---......TVV..RDV.ERPWAW...LGWV--AIFPLGLVGAL-favaal.....................................
A0A1W2FUP6_9PSEU/3-134 ............lqgv----LHRVFAFLIM..PVLGYL.....LGAT.I.FT.H...F....WD.KV.....-E.iADADLAV.T.--ALSCKEYGPVTW.....R.......G.......F..GFVSE.CRARVENKV....SG.....GATLTTV..RGFLAPHLV.GEQVVV...-----.---REFRRGEV......T--..---.------...------------------perpsagwgiavvvlfgvvwlylsawv................
A0A1H0BDI4_ALLAB/21-167 .........wtkltgt-------LLMVVAV..GALGYL.....LANT.A.LT.A...N....RL.PN.....-P..GPGDLRG.T.AVAQSCVDVGPVSS.....N.......G.......F..GTYAR.CTAEVSWEN....GT.....RETREFD..GSELTAKDV.GQAVRV...VRVNT.PP---------......---..---.------...------------------yqwlpapesyqrdggdragewtatmiyaivggvilfcgaavlg
A0A4V2EM92_9PSEU/18-163 ...............s-VRRLVRGFGVWAL..VVAMAY.....TVLA.A.FS.L...M....RV.DQ....rYDvyAPEDARD.T.ARVLACSQYGPISL.....S.......G.......I..GFYWM.CEVEVDTDW....SAry.gfKADMVITtrLSEFTPDDI.GHYIPA...-----.-----------......---..---.------...------------------dyyrydveryrygdpgpasialvvgavaiaattvfwlia....
A0A368VHR6_9ACTN/1-150 ........mrivrdif-------------L..VVVGIV.....LFLSnI.FL.V...F....PF.FGm...sTL.gSEVTARG.V.AVAKQCRFSGPVTE....tR.......Spe...reFmtGWWWI.CDARVRWDD....GR.....VEMREIV..YSQLTDADI.GREVEV...VAREE.IASRAGATRS-......VVY..RADfEPKPVW...AGVAMVVVSVVGLFVG--fp.........................................
A0A2R4FSV1_9ACTN/44-181 ............kagf----LSSLLFTLGV..LALAAG.....LLGV.G.VT.L...G....RM.SA.....ND.mADADREG.E.ATVSSCVERGPVTN.....R.......G.......F..GYWES.CQVKVVWEG....TE.....IEGMTIG..-VVFNSADI.GKTVRV...-----.-GDLGYNRSSR......QLA..RAD.VAPRPW...LEWIGYGFGALAMLPTL-v..........................................
A0A562V4C8_9ACTN/34-179 ...........gtgrv--ANVLKAVVLLTS..AVVFGL.....TLIS.I.GG.G...H....PG.FA.....PP..FAPMRTT.P.VEVLDCRTVTGIHW.....Y.......G.......V..GEWTE.CDVTATMPD....GE.....RITRTLG..RSVVSPDSV.GDTVTL..wT-RCD.ATLRWCEWYR-......SGD..PAS.TGPGPF...IQVVGRSVAAVCLVSA--aw.........................................
C4RFN6_MICS3/96-241 ................RLAQLGVAVACAAA..IVGSWL.....VFNT.V.AG.F...Y....PG.TGv...vKS..TPRERPA.R.ATVGECQRVGPVSG.....D.......G.......L..GYWWH.CAVTVRTDD....GR.....ELQIVTG..NSVVTPADR.GRPVDF..rEACFG.KGNTDCRYGR-......PAS..RVW.ALAVTI...LGMARIALTIVLIFGVW-y..........................................
A0A4Q7KQJ0_9PSEU/39-194 .........rwaavgq-------SVGTLAI..AVG-LAg...gVFLG.A.ST.V...R....TA.SG.....YQ.pGDPAGTV.P.AKVLGCAESDPISW.....Y.......G.......F..GRWAE.CEVEIIWKD....RP.....TTIVLEA..-PGLHVEDE.GRTVEL...ERFAQ.HDSESGRT-GY......DYS..PVG.TMHSDW...LYF-GVAI----------pltvlaallgllvcaaaaatvda....................
A0A1K0FF49_9ACTN/45-182 ...............e-GSATRSAAFLIGI..VLLTLV.....LIGA.S.IT.L...V....RM.AG.....RD.yADAKRTG.Q.AAVDTCTKQGPITN.....R.......G.......F..GYWEQ.CTVTITWDD....GT.....IARLNSD..-AVFTSADI.GADVRV...-----.-GDLGEYKTSK......KLA..RED.TPPRPW...LTWIGLFVGFLAVLPGI-v..........................................
A0A4Q7ZCV1_9ACTN/46-184 ..............rr--GRLRSIAGLLAL..VLGIIV.....VLQI.A.AT.V...A....TY.NG.....ND.fNDARRVG.Q.AKVESCDRRGPVGA.....-.......V.......L..GYWYE.CVLSITWND....GN.....VERGTVG.gPRLVHADDV.GKSIQI...-----.-GDNGTSRNGR......EYS..RPT.LPPRPA...LGVLGVVLGLIAGIPAL-i..........................................
A0A841FKC8_9ACTN/532-676 .......vagrgvral------------AL..TCTAAF.....VVLV.G.LT.A...A...sQA.GG.....RP.fENADGEE.R.VLVTACRDGAPMGP.....H.......G.......F..GSLPE.CE--VSRPD....GS.....AVWVTGG..--EFGPADL.GHYVTA...-AYVD.VDASASWYERLfgtpgpSVV..RADrERDWSA...LPMLVFALCGAALV----fvqa.......................................
A0A7W9LZD6_9PSEU/1-143 .........mkavagl-----IA----VAV..WATAIM.....LGLT.G.MT.H...Y....QP.QA.....AT..VDISDRG.T.ARVADCAEEGPIGG.....L.......G.......V..GYWWT.CRADVTWDG....GA.....RERVTAQ..PGQFTPDDR.DRDVPV...VQRTV.LGNKGGGPGTP......KVY..RAD.FEPSAV...L-GVGSLLAGIGLGGL--lali.......................................
A0A1Q8CPM0_9PSEU/1-137 ...............m------RALALFPA..AVVAFL.....LLAT.V.LR.M...A....DV.LV.....GS..PDATRTG.T.ATVTSCAEYGPVGR.....W.......G.......L..GVSFG.CSAEVRWTG....GG.....TERVVFP..PGQLAPDE-.-RDVPV..fESGRE.PGRNDSAR---......---..---.------...------------------wflaghvaavamalltlwftlgalgslvrvrp...........
A0A344LF67_9PSEU/22-169 ..............la--GWLRFVLSWLAL.pVLFFLT.....LTLG.T.VD.L...H....LQ.RG.....AA..YTVEETG.TvAYVKECSEYGPISH.....A.......G.......F..GFHWA.CSVDYGYAG....HT.....LEPRSREtlSSVFTPADV.GKTLAV...EEIGK.DLHRYHETGEL......TWA..KVW.VLVPIG...FPVLALCY----------aglrrwpswm.................................
A0A7Z1B0Q5_9PSEU/1-134 ..............mr-------ALAFGLA..TVIGLL.....LLAT.V.VR.A...T....DV.LV.....GP..PEADRTG.T.ATVTDCTTYGPVGR.....W.......G.......V..GTSHE.CRADVRWDD....GV.....TGTVTFP..PGQLAPGE-.-RDVAV...---FD.SGRSPGA---N......DSA..RWT.-LAGPV...LSI---------------alglltvwfaaatigllip........................
A0A344LF69_9PSEU/17-162 .....qtpreklvgwl-----QCAVFWLSI..PVL---.....FFGT.L.TL.F...HlddqLQ.RG.....AE.yTVDETGE.T.AYVRECAEYGPISH.....A.......G.......F..GYHWS.CSIDYKRTGl..aVR.....PERKETL..RSVFTPADI.GMTFAV...-----.-KKSGKHFYR-......---..HHH.DNPYPW...AHVLLVFPLALVIFV---liyal......................................
A0A318LYH3_9PSEU/23-153 ..............rl--AMFGESVATWLV..LVVAVL.....GLLT.A.FR.I...A....DA.PE.....NN.tRTGSGAA.L.AQVESCERRGPVST.....G.......G.......L..GYFWE.CTARVPGVD....GP.....VAFRADE..---LTAADI.GRTVPV...-----.------RQDDG......KWV..RDV.GHPYGF...LTVLVWVAVAGGVVF---vwa........................................
A0A563EYB8_9PSEU/3-134 ...........ivlhr-------FFAFLII..PALGYL.....IGAT.I.FIhF...W....DI.AE.....TD..DLSEASH.V.ITAQSCVRHGPVAL.....R.......G.......F..GYWYD.CRATVKNKV....NG.....NVVTATA..RGFLKPELI.GKDVA-...-----.-----------......---..---.------...------------------gtgfrrgalaperpyqglggfltlvfaclwiyvmar.......
A0A4Q7JEW2_9PSEU/32-159 .............vvq---LLVQGAVRAAL..VVFALV.....VFLT.A.TP.L...I....GG.KT.....--..---GRTG.T.AELTGCA-----SG.....D.......L.......F..GWVVA.CQARVTWPD....GE.....ITTHRLE..SADLTAGDS.GRSVRA...-VEHG.SARVPTAVALD......LPH..RYT.ALGWSL...LT----------------svagvallwpy................................
A0A0A6UBJ1_ACTUT/2-139 .............ptw---------GLLLA..TVAGWL.....VFNA.G.AT.I...G....RH.TG.....GD.fGDASVEG.T.ATVERCERRGPLTV....lQ.......G.......I..GFYDV.CYLWVEWDR....EGwrqypAERILVE.eAGFFKGEQP.GDRIRI..gY----.-----------......---..---.------...------------------gisrpelrespahvlamialcaaggsiflvgslvll.......
A0A2V4B310_9PSEU/7-149 ..............lg--GRIARAVVLWLV..LVLTLL.....LTAT.V.AR.V...T....YG.GG.....--..PEVERVG.T.ASVRSCTEHGPVSL.....S.......G.......I..GTVYT.CTAQVRWSD....GD.....TETREFP..AGQLGPADM.GTPVPV..yLDIGE.GRGEGPVVGRN......GSA..RFA.ELELPA...VLLFGFLALALGIGALY-a..........................................
H5X4G0_9PSEU/8-170 ...............a-VARVARALGWWLM..VLVGLL.....LLAT.V.NR.V...T....YG.GG.....--..PEVDRIG.T.ASARECVEYGPVSL.....H.......G.......F..GTTYR.CTAEVRWAD....GD.....VEQREFP..AGQLSPSDV.GTPVEV..yLDIGD.GVQEETTIGRN......GSA..RFS.ELRFPV...KIALGFAVFLVLGLGAL-yntyrvfrpgtgsdtesdsgg......................
A0A8J3C2N4_9ACTN/17-163 ...............pRLRDLVLAVGWACA..TVL---.....LFLS.A.ST.L...L....SLdHG.....VD.sPFADYPA.V.AEVGRCHRYGPVSL.....D.......G.......F..GWFWA.CEVTVRTAD....GT.....VHAVVDG..-SKVTPNDA.GRQVRF..rEYCDD.SG---CSYG--......---..---.------...------------------rptlwlwrlvvalfdrtavtadvimaivavgylvaali.....
A0A2T0GU94_ACTMO/3-155 .......vfvrlardv------------VL..IPLGLL.....LFAA.SiLV.V...I....PF.FGl...gAV.gSEVTDRG.T.AVAQRCRFAGPIADsq.spD.......Gg....svV..GFGHI.CRARVTWQD....GT.....TEMREVT..GSQLTPDDI.GREVAV..vERAVD.TGNGGSTSTEQ......EVY..RQD.YRPKPV...LGVIGILATGLPAV----gcvl.......................................
A0A7W7GUU2_9ACTN/45-183 ...............r-GAWAGDLVVLVVL..LFVLFV.....LLTT.A.MT.V...E....RF.SG.....HD.fAEARRTG.D.ATVVSCARRGPVTF.....K.......G.......F..GYYDA.CTVSVNWGW....NG.....TRLTIDQ..PGFFKGEKP.GDTFTI...-----.-GENQSSRGTI......GFS..RPV.VPSRGW...VTAVAMVIACVALIPF--fl.........................................
A0A263D3P7_9PSEU/1-128 ............mllw---------VSLLV..LVLSSL.....AI-A.R.AS.E...Y....PS.VG.....AV.aPTQGLDG.T.ASVTGCRDLGPFTG.....Y.......G.......L..GRAEV.CTAEVSTPD....GD.....LGPIEFR..VGELTPADI.GRTVAV...--RPD.DG---------......EWV..RDV.DHPYDE...IVWSYIVFLIVLVL----pvvf.......................................
A0A7W5AHU4_9ACTN/45-182 .............gsr---PLRDVSFLLAI..IMLSGI.....VLLA.G.MT.L...V....RS.AG.....RD.fDDARRAG.W.ATVDRCRGHGPVTG.....K.......G.......F..GYWET.CDVTIRWDD....GT.....TGSLTKD..-GVFTSADI.GSNVRV...-----.-GDLGRYRTST......ELA..KQD.APYRPW...LKWIGVFVALAGLLPGLF...........................................
A0A1W2FCN9_9PSEU/1-153 ........mlrkiarl-----VAGLVGLAL..WATVAI.....AGLT.G.YT.Y...F....KP.AA.....AT..TSVSDRG.V.ARVADCRREGPVSV.....S.......G.......F..GYWWL.CEADVVWDS....GG.....RQRVTVQ..IGQLSPDDA.GKDVPV..vQ----.RLVTDKASRAA......AVY..RAD.-FEPSV...VLGLGSVLGGLGFGFL--lfvivfgstlsa...............................
D3PVX1_STANL/3-143 .......snrrgpsaf------------LL..LLVGIA.....ALAT.G.WT.A...M....NY.RGgvsdkED..LSNRDKA.T.ATVVGCEQDGPVSV.....S.......G.......V..GYWWN.CDVDITTKD....GE.....TTRQSLP..GSRFEPADK.GKKFEM...--VAG.GFGASS-----......-WV..RTD.VPANNLattITAAGLLVGVGC------lvvglh.....................................
A0A1H3APQ7_9PSEU/16-153 ...........krstv----IRAALIVIAA..VVV---.....VWTA.A.GH.A...A....SF.HG.....AE..KTDQPLG.V.AYAKSCVEKGPFTE.....A.......G.......I..GFFWA.CTAEAHWQGglykGD.....VKTVVFG..LDELTPADI.GKPVTF...-----.-YKYGKRY-WR......HAE..RPY.EGPVEW...SVAGAVVVLIG-------ggywlw.....................................
A0A1W2FSP0_KIBAR/8-144 ...........yhwpa--------FVLAGV.lALLGIW.....AFIA.V.QH.R...M....GL.TT.....SE.lPQAERTG.E.AQTQTCSRD-PLYL.....-.......-.......-..WITWT.CDAQVRWNG....ET.....NTVAER-..--VISVREL.TGTVDV..hERV--.-----------......---..---.------...------------------vprkrvstarevvsadfpgtsdgalffvmmmgfpvagaaagyf
A0A239D2I2_9ACTN/1-141 .........mkrflls--------LVLLLA..AGALGL.....LVPT.V.AR.N...S....QP.DF.....--..AKAEQVG.T.GIVSACSEQGPVTL.....G.......G.......F..GYTSK.CQLDVTWQD....GS.....RHFVDPD.rYGFADFAEI.GKTITV...GDLGD.GEYARPDRPFR......PLV..VAS.AWALAI...LAVAALVTGVLG------vrrvi......................................
A0A543B0Q3_9ACTN/3-142 .......tstrtnspv-----------ILP..ILIGIV.....LILG.G.WT.A...M....NL.RGg..vsAD.dTADREEA.T.ATVESCEEVGPLSL.....S.......G.......V..GYWWS.CRAMVTTQE....GD.....SYSQVFN..GSQFAPDDV.GSQFPI...-----.-VNAGQ--DSN......SWT..RAD.LPHNNW...AIVA-TAVGLIA------gaiclivgi..................................
A0A327ZJD0_9ACTN/39-176 ................RGGKLGSAAFLAGI..VLLAAA.....LLST.C.VT.L...I....RL.SG.....HD.fAEASRTG.Q.ATVAHCTEQGPVTT.....R.......G.......F..GYWYR.CVSTIRWDD....GG.....TDRLVID..-EVFTPADI.GRAVRV...-----.-GDVGEHRGSR......ELA..RED.TPARPW...LTWIGVTVGIIGLLPTF-l..........................................
A0A839E518_9PSEU/6-151 ..........mtvriv------REIVLLAV..GVVFSF.....QYFC.G.PT.L...F....RY.GR.....--..VRCDGAR.V.CCFPECRFTGPVTD.....SlepdsenI.......T..GLWWL.CTGEVHWDD....GA.....VERREFS..YSPLRGDKT.GRTMRV...VEREF.PDTGGPTYTR-......-VH..RAS.FGPAPV...RGGAVAIFTGLA------ggvtg......................................
A4FM92_SACEN/10-147 ................RLAKMLGGFVVVAV..LVM---.....LWPT.I.VY.S...F....PE.KK.....--..--DNPNG.T.ALVRSCEDTGPVTR.....R.......G.......F..GHNWS.CVADIRDDK....TG.....DTWTATV.dMNFFTPAEV.GKQKRL...VWGYG.GSRTSTNKEKR......TYT..RAE.DGYSNG...TVTLVLVVTTGLVGIPA-l..........................................
A0A4R6SDJ7_LABRH/73-210 ..............al--TTLRDAVIVFLA.iGVLSMV.....AGMT.V.YH.R...T....DV.TY.....LG..SVVTQRG.T.IRVADCD-EGPIFG....lH.......G.......Y..GRTAT.CHGKVTWAD....GP.....SEQVRLN..--GLGRPDV.GKSVPV...-----.-ARERLLTGTL......VVT..RDD.GHPWLL...AGLLLG--TPL-------lllalwllvl.................................
A0A344LF74_9PSEU/18-155 ............klgg----LLRFVVFWLS..IPGIFF.....LGLT.V.MH.A...D....QL.NKr...gAA.yTVEETDR.V.AYVKECNQYGPFSH.....A.......G.......F..GFHWE.CSVDYGAPG....GK.....LKPFSQKtrSSIFTPADI.GKTFAV...KKI--.-----------......---..---.------...------------------gkfleryhevdrfnwaslhsvfpfaivaliat...........
A0A255ELQ4_9ACTN/13-91 .........awltgtv-------LAVVVGL..WVVGAL.....LAIQ.V.IT.A...L....GG.PG.....EG..ASTTRRG.T.ATIISCESA-----.....-.......S.......F..GLVQE.CQAEVTWEP....--.....-------..---------.------...-----.-----------......---..---.------...------------------etqwdeadlpt................................
A0A0A6UQL2_ACTUT/52-189 ...............k-GSTLRDVTVLALI..LVLSFL.....VMGS.G.FT.L...L....RS.AG.....RD.fSASERLG.W.ASVTACAEHGPIST.....K.......G.......F..GYWGT.CRIVIRWDD....GT.....TDRLVND..-ADFSDADI.GREIRI...-----.-GYVGEHRYQL......ELA..RED.APYRPW...LTWIGVVVALVGGIPLF-i..........................................
A0A1W2FGJ6_9PSEU/1-139 ..............mk---ALHRIFAFLLV..PFIGYL.....LGAT.I.FN.F...F....WD.KA.....EP.gDLAKADM.I.VVAQSCERKGPVAW.....R.......G.......F..GYYYK.CKVQRRFAD....GD.....TNTTTVT..-GWLDPSDI.GKEYAA...---NT.PRRSQPAPEER......PYD..WAA.GLCTFV...FGI---------------lymfviakvavpam.............................
A0A3N1AVV4_9ACTN/4-150 ................RLRQLFFMILTLAV..ASVFLF.....LYLT.V.IS.L...Y....PG.TGv...vRP.yGPIEQSV.Q.VKVEECRRVGPVSD.....Q.......G.......L..GYWWV.CRLLIERDN....GR.....TVEAVVG..GSVVTPKEL.GRVVTI..rEACRD.PGQNECAYGK-......PVS..RVL.ELLYGV...FQIFSRVLGVFFILMSL-l..........................................
A0A1G9D2Y8_9ACTN/2-156 ....rvvrfirdvllv--------------..-PVGVA.....LFLSgI.LV.V...I....PF.FGf...gVV.gSEVTARG.T.AVAQQCRFDGPITEsdapeR.......Gn.....iV..GFGYI.CQARVTWRD....GT.....TEMWEVS..GSQLKPGDV.GEEVAV..vRRAIR.SGGAGTTSTRP......EVF..RAD.YEPNIW...LGVPVMLAVMLFGF----mvgvpa.....................................
A0A3N2NYI1_9ACTN/51-188 ................RGGALRSFLFLAGT..LVLAAS.....LFGV.A.VT.L...S....RL.AG.....SD.mADATREG.Q.ATVTSCHGHGPISS.....R.......G.......F..GSWES.CEVEIVWSG....GE.....VEHATVG..-AVFTSVDL.GRSIRV...-----.-GDLGRHRGAR......KLA..RAD.VEARPW...LRWLGYGVGALALPPAL-v..........................................
A0A840NEE8_9PSEU/26-165 ..........rggrlg------YIASQIVV..RLLVLL.....VFHT.V.MG.A...T....GI.TT.....TD..GTPTDRG.T.ALATRCERVGPVSM.....S.......G.......L..GWWWV.CDATVTWED....GS.....SEQRTFK..FSDLTPDNR.TTPAPV...-----.ERRELDNRGS-......NVV..IAD.PAAPAA...LGWA-LFV----------pllglallgvrip..............................
A0A563ET08_9PSEU/10-146 .............krr---VLRLVFAVLVM..PLLGWL.....LGAT.I.IN.A..fT....DR.YG.....PD.pAPRPGQT.F.AIARECDRHGPVST.....H.......G.......F..GFWHQ.CMADLGQHD....GP.....FARRPVN..--FLTPADI.GQHVPV...-----.-VKEGTGRRS-......HHV..RAA.DQPLAW...WGWLALPFALG-------wlyltyl....................................
#=GC seq_cons ..............hh.......hhhhhhh..hlluhl.....lhhs.s.hs.h...h....th.su......s..ssspppG.s.AsVpsCpctGPloh.....p.......G.......h..Gahap.CpspVpWs-....Gs.....spphphs...u.hossDl.GpsVsl..........sttttth.t.......ths..+......hsh...hhhhhhhhhhhh......hh.........................................
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