#=GF ID DUF6349
#=GF AC PF19876.3
#=GF DE Family of unknown function (DUF6349)
#=GF AU Williams LS;0000-0001-5551-8526
#=GF AU Finn RD;0000-0001-8626-2148
#=GF AU Fragoso S;0000-0001-7018-3891
#=GF SE Manual
#=GF GA 25.00 25.00;
#=GF TC 25.00 25.40;
#=GF NC 24.80 24.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF WK Domain_of_unknown_function
#=GF RN [1]
#=GF RM 16766657
#=GF RT Amplification of the entire kanamycin biosynthetic gene cluster
#=GF RT during empirical strain improvement of Streptomyces
#=GF RT kanamyceticus.
#=GF RA Yanai K, Murakami T, Bibb M;
#=GF RL Proc Natl Acad Sci U S A. 2006;103:9661-9666.
#=GF DR INTERPRO; IPR045930;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This entry represents a member of a biosynthetic gene cluster
#=GF CC (BGC). This BGC (BGC0000703) is described by MIBiG as an example
#=GF CC of the following biosynthetic class, saccharide, in particular
#=GF CC the kanamycin biosynthetic gene cluster from Streptomyces
#=GF CC kanamyceticus [1].
#=GF SQ 50
#=GS A0A1J6XTY3_9MICO/24-207 AC A0A1J6XTY3.1
#=GS A0A4P8H843_9MICO/30-212 AC A0A4P8H843.1
#=GS A0A4R4NXK7_9ACTN/12-192 AC A0A4R4NXK7.1
#=GS A0A6G8FQM8_9MICO/28-208 AC A0A6G8FQM8.1
#=GS A0A8J8BDX6_9ACTN/3-123 AC A0A8J8BDX6.1
#=GS A0A542E0V1_9MICO/4-75 AC A0A542E0V1.1
#=GS A0A066Z0T1_9ACTN/127-289 AC A0A066Z0T1.1
#=GS A0A200HD00_9ACTN/29-218 AC A0A200HD00.1
#=GS A0A239PF56_9ACTN/46-226 AC A0A239PF56.1
#=GS A0A291W4A3_9ACTN/9-187 AC A0A291W4A3.1
#=GS A0A6G7XLB6_9ACTN/27-216 AC A0A6G7XLB6.1
#=GS A0A7L5Z0F1_9ACTN/32-221 AC A0A7L5Z0F1.1
#=GS A0A6B2S0B8_9ACTN/10-191 AC A0A6B2S0B8.1
#=GS A0A2T0N2L5_9ACTN/7-171 AC A0A2T0N2L5.1
#=GS A0A4P6KH15_9MICO/93-172 AC A0A4P6KH15.1
#=GS U2TFL6_LEIAQ/25-205 AC U2TFL6.1
#=GS A0A1G9F453_9ACTN/10-192 AC A0A1G9F453.1
#=GS A0A7J5B8D5_9MICO/32-217 AC A0A7J5B8D5.1
#=GS A0A1R4GNF0_9MICO/31-215 AC A0A1R4GNF0.1
#=GS A0A2A3Y4Q4_9MICC/40-206 AC A0A2A3Y4Q4.1
#=GS A0A6I3IEE3_9MICO/2-70 AC A0A6I3IEE3.1
#=GS A0A2W2E3V2_9ACTN/17-182 AC A0A2W2E3V2.1
#=GS A0A1C4P698_9ACTN/10-177 AC A0A1C4P698.1
#=GS A0A177YEX6_9NOCA/30-215 AC A0A177YEX6.1
#=GS A0A646KTM1_STRJU/10-177 AC A0A646KTM1.1
#=GS K7RWF1_ACIA4/30-197 AC K7RWF1.1
#=GS A0A6I6SCS6_9ACTN/10-192 AC A0A6I6SCS6.1
#=GS A0A2T0U9X1_9MICO/28-208 AC A0A2T0U9X1.1
#=GS A0A7M3M206_9ACTN/9-176 AC A0A7M3M206.1
#=GS A0A1V4A266_9ACTN/10-192 AC A0A1V4A266.1
#=GS A0A3N6WJR7_9ACTN/25-206 AC A0A3N6WJR7.1
#=GS A0A1Q9TLM6_9ACTN/5-144 AC A0A1Q9TLM6.1
#=GS A0A059W6L8_STRA9/10-177 AC A0A059W6L8.1
#=GS A0A161V2K1_9NOCA/30-215 AC A0A161V2K1.1
#=GS A0A117RN59_9ACTN/10-192 AC A0A117RN59.1
#=GS A0A1Q5LKB5_9ACTN/10-192 AC A0A1Q5LKB5.1
#=GS A0A1U9ZXZ9_9ACTN/12-175 AC A0A1U9ZXZ9.1
#=GS A0A7X6CWP3_9ACTN/10-191 AC A0A7X6CWP3.1
#=GS V8D3X3_9NOCA/28-209 AC V8D3X3.1
#=GS A0A646KVR5_STRJU/9-189 AC A0A646KVR5.1
#=GS A0A6G7YGB3_9ACTN/27-216 AC A0A6G7YGB3.1
#=GS A0A3P5XEL9_9MICC/24-207 AC A0A3P5XEL9.1
#=GS A0A0N1NUJ0_9ACTN/6-170 AC A0A0N1NUJ0.1
#=GS A0A4V0Z1F7_9MICO/1-95 AC A0A4V0Z1F7.1
#=GS A0A7K1ULY0_9MICC/29-210 AC A0A7K1ULY0.1
#=GS A0A2N9JCP2_9ACTN/27-224 AC A0A2N9JCP2.1
#=GS A0A7H8NAJ3_9ACTN/10-192 AC A0A7H8NAJ3.1
#=GS A0A061LZA2_9MICO/28-208 AC A0A061LZA2.1
#=GS A0A0A8EX43_9ACTN/10-177 AC A0A0A8EX43.1
#=GS A0A4Y3USK0_9MICO/30-211 AC A0A4Y3USK0.1
A0A1J6XTY3_9MICO/24-207 ...........................GAPLAYTT-SYYSPA--....ELDAAFDRYRAefgg.fgciPRSHMw........hRN.SYNQGERAATADGHELHMFYADAWCkeadhdh............sadplpgGGRYQAVCPGCA.WH.....-VISE......REND..AVEAW..HDHALPGW.RSLPIMprpaaaaTDEKKARAAAAKW---CAANY...PAEWQRPGSPVRTIRGPH.....GG.RHVESRSPFG.GYDLAA--------d..............
A0A4P8H843_9MICO/30-212 ...........................GAPLSFTR-DYFTPARF....--DEAFEHWKFlngs.lgswKRSHM..........WH.REGWNGAGTEFGEHRGEIFSAELSPedgh..................egpgGMLTQMICELCD.WH.....-VIAE......DDNT..AVEAW..HDHAVPGW.RELPVLpaairvrDGGATLSKLAMKW---ITERY...PQHMQVPGAPIITERSSS.....GT.RHVHHYSPWG.GYDLSHTALERP--aa.............
A0A4R4NXK7_9ACTN/12-192 ...........................GAVERQHRYWRIRNARTralqALLPAGRAWHI.........APGHP..........GGaYSDLGTGPGVRDRHLPTLLTRDVDDr........................rQEIYRGGCLGCA.WE.....GSEHGgrgwreGANQ..AVEDA..HDHAFPSW.RSLPVLd.....lRTAA-SPHRAERLWRGITTRY...PSGWVDAGAPALCTRPGA.....DA.LHLPPSGRYP.RYRLFVKKPP----hrgt...........
A0A6G8FQM8_9MICO/28-208 ...........................GAPLRFTT-DYYSPD--....ELDTAFAHWRFlngg.fgsiPLSHM..........WH.EAPASGSNISFGEHSIVVLTADLRPepgv..................igpgELLYQAICEPCD.WH.....-QISH......PENS..VVEAW..HDHAVPGW.RELPVIpaq.irvRTETGLTKLAQAWIAE---HY...PKHMQIEGAPIITERTQF.....GT.RHVPGYSPWN.GYDLSSTALD----ttv............
A0A8J8BDX6_9ACTN/3-123 .................ptsssstsgn-----------------....-----------.........-----..........--.------------------------T..........................HGAYAAFCRDCA.YL.....GPWHG......SEEA..ALQDG..FDHAFPGW.RELVPVva..amtYNETQNKTAYAQWRQSIVELY...PAGWVEAGGPVLIARNRR.....GT.RWHDDWFLGG.NYNV----------cgveraid.......
A0A542E0V1_9MICO/4-75 .....adgrkheatlvklpkveredsp-----------------....-----------.........-----..........--.------------------------Avv......................ekGSFTFGYCKSCD.WT.....GPARR......ARDK..AVRDAvrHDGACPG-.------.......---------------------...------------------.....--.----------.--------------kpnvrvgv.......
A0A066Z0T1_9ACTN/127-289 ...........................GAVARHNTYLTLSKTAA....PRDTIRSAWHI.........SWGHP..........--.GFDPTNPTTRTEQHAATVIEQSADL..........................P-ARRGACLACP.WE.....GPIRR......DHNT..AVEDA..LDHTHPGW.RRLPTI.......-PQGTSGKNAHLLRAYLDAVY...PTGWFETGGPLKVYTSTA.....ND.RHEPGKARGG.GYLVKVYRSSYT--pe.............
A0A200HD00_9ACTN/29-218 ...........................GAPLHFTA-DYYPPG--....ELDAAFAHWQFlnrgvlgsyAASRM..........WH.RAIAVAGNVQVGDHGFDMFTADLRCnddthrh............gncsclgDLVYQAVCEPCD.WH.....-AITD......GENE..AVEAW..HDHAIPGW.RELPIVpahirmvDASMRPSKQAREWVEK---HY...PEAMRFPGAPVITERPNF.....GH.RHVPGRSPWN.GYDLSHTAVDPD--rv.............
A0A239PF56_9ACTN/46-226 ....................aapslyd------------SPSRGl..vARTAEVEAWRArygn.wssiRRSHA..........-W.EVHITCPDTPTARCQPTVLSADLRCdcldn................cccvgDLLYRGACRGCD.WE.....GEPRN......QENA..AVEDA..CDHAWPGW.RDLPVV.......PRVPEDRKRHGAWVDRVATHY...PTKWLTDGGPIRTRRSGL.....AT.RHVPGRTPFG.GYDLAAEDPADA--aa.............
A0A291W4A3_9ACTN/9-187 ...........................GARARQNYYWRVRNHRTp..lRADHACETWHI.........RHGHP..........GGaYSDLGHGLTPLEHHSPTLLTRRTCGr........................dDDQYRGGCLACD.WEgsitaGPEHA......AFNT..AIEDA..HDHAFPDW.RSLPTTs....hrAAPWDLHRNRVVW-AQITAGY...PGGWVERGAPLVVWARYR.....AD.LHQPPHGRRP.RYELRIPKPRRDE-a..............
A0A6G7XLB6_9ACTN/27-216 ...........................GAPLHFTT-DYYSPG--....DLDAAFEHWQFlha..hdpvQ---Sgs.....rlwS-.RSIAVPESRQVGGHGFVLYTADLRCepwkhaek..........hegcmcvgDLMYQAICEPCE.WN.....-AIAD......RENG..VVEMW..HDHALPGW.RELPIVpar.lrmLDKVGLSKAARKWIEE---HY...PRSMQVPGAPIITERRPF.....GT.RHVPSRSPWG.GYDLSHTAVDP---eri............
A0A7L5Z0F1_9ACTN/32-221 ...........................GAPLHFTV-DYFSPD--....DLDAAWAHWKFlhqgsxgayALSKM..........WH.RAIAVPGGIPVGDHGFDMFTADLRCladehrh............aecacigDLLYQSVCEPCG.WH.....-AVGD......SENG..AAESW..HDHAIPGW.RDLPIVpisipvvDSNMRITRQVRAWVEE---HY...PEDMQFPGAPIITERRGV.....GH.RHVPGRSPWA.GYDISHTAVDPD--rk.............
A0A6B2S0B8_9ACTN/10-191 ...........................GARARQTYYWRVRNARTr..hRPETAAQAWHI.........QPGHP..........GGaYCDLGHELDPPAHHTPTLISRSRWTgr......................reEQQFRGGCLACD.WE.....GPVHRgsgygdGDNE..AVEDA..HDHAFPGW.RTLPPIt....ivEDRWAVKQSRSRW-AQLTSQY...PEGWIDQGAPVLAWSRYR.....RE.AHAPPNAGHP.RYELHVARPPS---grs............
A0A2T0N2L5_9ACTN/7-171 ...........................GAAARHAARRQLPI---....--GEGRGQWGI.........YFAHP..........GAnVRGNDEFPSTAPDHRPTILFRVVDEp.......................kwHQLYRGACLGCD.WE.....GETRE......RERD..AVEDA..HDHAWPGW.RDLPGV.......---KPSKSNYERWLSDVKRAY...PPGWLEAGGPIVTIRADS....rFS.RHSPGRAPGG.GYDLAASYYQT---kktq...........
A0A4P6KH15_9MICO/93-172 .........................la-----------------....-----------.........-----..........--.-------------------------..........................------------.--.....-----......----..----E..HDHAMPGW.RALPILptn.lstADEKKARAAAAKWCAE---NY...PAEWQRPGAPVISRRGPY.....GG.RHVGGRSPFG.GYDLAAP-------nd.............
U2TFL6_LEIAQ/25-205 ...........................GAPLSYTA-DYYEPA--....ALVAAFERYCAehgh.fgciPRSHM..........WH.RAYYLDGPTVTEGHELHMFTADAWCrevdhdh............saaplpgGGRYQANCPRCA.WH.....-VITD......NESA..AVEAW..HDHALPGW.RELPILp....rkLARFENKQRIAAVAAWVTATY...PAAWQRPGVPILTERGEH.....GR.RHVPGRSPLG.GYDLAA--------d..............
A0A1G9F453_9ACTN/10-192 ...........................GARARQTYYWRVRNARTr..hSPPSAGQAWHI.........QPGHP..........GGaYCDLGHELDPPSHHAPTLLSRSRPTgr.....................rgdERQFRGGCLACE.WE.....GPVHSgdefgkGGNE..AVEDA..HDHCFPGW.RTLPPIt....tvEDRWAVPRNRSRW-AQLIARY...PAGWIDQGAPVVAWRRYR.....RE.AHAPPHAGRP.RYELHVTRPPND--rg.............
A0A7J5B8D5_9MICO/32-217 ...........................GAPLHFTT-DYYAPD--....DLTAAFERWVFehgn.fgclQRSHM.........wHP.GYTTAEANTATVGHELRIFDVDLRCthyre...............dcscvgGLLTRGICAPCR.WH.....L--DG......NEAT..IVEAW..HDHAWPGW.RTLPVIpasiaktDDQNRPTKKYRAWIDE---HY...PAEWQLPGAPVITERQPY.....GT.RHVPGRSPWQ.GFDLSHTALTTE--pq.............
A0A1R4GNF0_9MICO/31-215 ...........................GAPLHFTT-AYHSPD--....DLEAAFERWVFehgn.fgclQRSHM.........wHP.GITTAHANTATAGHELRIFDVDLRCdhyre...............ncacvgGSLTRGICHPCT.WH.....H--DG......TETG..VVEAW..HDHAWPGW.RTLPVIpakiaktDDQNRPSKKYRAWIEE---HY...PAEWQLPGAPVITERSRY.....GT.RHVPGRSPWN.GFDLSHTATH----ptg............
A0A2A3Y4Q4_9MICC/40-206 eamydakiahhrefhvdkgnwkpyrgw-----------------....-----------.........-----..........--.--SAQEASGKDSAHQATCYDAELRCsahwgk..............gcqcvgSLVYRVYCHDCEhWT.....G-IYA......QASQ..AWEAH..LDHCWTGW.RDLPVL.......--ESKPSGYSYKW--NIPDGY...PEKFTQPGAPIRDCRGNSk...yGT.RHVPSHSQYG.GVKVGVTQD-----ckthn..........
A0A6I3IEE3_9MICO/2-70 .................ieteprdpsh-----------------....-----------.........-----..........--.--------------EPT--WHVVED..........................GSFCRGECLECR.WH.....GPGRR......SRGS..ARKDA..ELHALTG-.------.......---------------------...------------------.....--.----------.--------------cgdetqlrslfpaga
A0A2W2E3V2_9ACTN/17-182 ...........................GAVARQLHYRTLTNPQA....------GAWAI.........YITHP..........GNqLGRARAPLQQADKHLPTVLFQVGRH..........................PHRFRGACLGCV.WE.....SSQDF.....gHVLD..AVEAA..HDHTHPGW.RNLLPVh.....ePPKDYGKAKMRRWLNDVTAVY...PLGWFDSGGPVVTIRRDP.....ANrRPLPGRAPGG.GYDLPAHDLPAHD-h..............
A0A1C4P698_9ACTN/10-177 ...........................GAVARHTAYLPHFWD--....KATNSRPIWRI.........DWGQP..........--.GFSQRTPPEPTSDHRPTVLARSWERpapdg................tgetwPYLHRGACLGCT.WE.....GPDRR......RTDE..AVEDA..HDHTHPGW.RDLPAV.......-----PEHQGRRWLTHVQRLY...PDGWFDRGGPVRTVRTGI.....EK.RHRPGAAPGG.GYDLAVQPPRRN--dt.............
A0A177YEX6_9NOCA/30-215 ........................gip---ILFAS-----PTRGv..qARVAEFETWATtwgr.hgstAASHA..........-F.CPGICDPSAPTEICQPTCIAADLDCccpdtsr...........dtacqcvgGDLYRGACTGCP.WE.....GENRA......DESE..AVCDA..LDHAQPGWiDDLPIV.......IPERTPSQKDEVWTAKVIDIVgerPTGW-----PVITRRGVT....iGL.RSVPHRSPWG.GYDVAAATAEAH--la.............
A0A646KTM1_STRJU/10-177 ...........................GAVARHTAYLPAFWD--....KSTNSRPIWRI.........DWGHP..........--.GFTHRTPPEATPDHQPTALTRSWEQpapdg................sgetwHHLHRGACLGCP.WE.....GPDRR......RADE..AVEDA..HDHTHPGW.HTLPAV.......-----PERQGRGWLTHIQHLY...PDGWFDRGGPIRTLRTGI.....EK.RHRPGAAPGG.GYDIAVRPTKRS--pn.............
K7RWF1_ACIA4/30-197 .........................gi--PLGITVYDYHDPE--....ELRAAMVRWLA.........EHGEFaggggmwcelLA.GDDIGEPVAAADGHELFEFAA---Qpa......................glAVIHQAICPGCR.WH.....--HIG......TGKE..VVEAW..HDHAMPGW.RELPVV.......---PKPVTDIAEWMEG---AY...PPGWVRPGAPIRTRRHPKtrarrFD.SHVPHGSPMG.GYDMAAPA------e..............
A0A6I6SCS6_9ACTN/10-192 ...........................GARARQTYYWRVRNARTr..qSPGSAGQAWHI.........QPGHP..........GGaYSDLGHELDPPEHHAPTLLSRSRPTgr.....................rgdEQEFRGGCLACE.WE.....GPVHSgngfgdGDNE..AVEDA..HDHCFPGW.RALPPIt....tvEDRWAVPRSRSRW-AQLTSQY...PAGWIDQGAPVVAWRRYR.....RE.AHAPPYTGRP.RYELRVTRPP----idrg...........
A0A2T0U9X1_9MICO/28-208 ...........................GAPLHFTT-DYYPPA--....MLDEAFAHWRFlngd.fgsfGRSHM..........W-.HRSISGGTVEFGEHRAESFTADLRPepga..................egpgDLLTMVVCEPCE.WH.....S-PAG......SENE..AVEAW..HDHAVPGW.RELPVVprq.vrvRSETGLTKVALRWIEQ---RY...PAHMQVPGAPIITERAQY.....GT.RHVAGYSPWG.GYDLSATALERP--ar.............
A0A7M3M206_9ACTN/9-176 ...........................GAVTRHTDY--LPHYRD....KNSNSRDRWRI.........AWGHP..........--.GFTHHTPPEPTADHQPTVLVRNWGRlapdg................ssdlwTYLHRGACLGCT.WE.....GPDRR......RTDQ..AVEDA..HDHTHEGW.RDLPPL.......-----PERRGRHWTTHATHLY...PKGWFDTGGPVRTIRTGI.....EK.RHLPGKAPGG.GYDLAVQPPRTE--hr.............
A0A1V4A266_9ACTN/10-192 ...........................GARARQTYYWRVRNARTr..hRPETAAQAWHI.........QPGHP..........GGaYSDLGHELDPPAHHAPTLLSRSRPTgr.....................rgeKQEFRAGCLACG.WE.....GPVYSgggfgdGDND..AVEDA..HDHAFPGW.RTLPPIn....tvEDRWAVPRSRSRW-AQFIARY...PAGWVEQGAPVVAWRRHH.....RE.AHRPPYAERP.RYELHVPRPPRAQ-s..............
A0A3N6WJR7_9ACTN/25-206 ...........................GAPLTYTT-DYYAPE--....LLDAAFERYQLengq.lgslRTSHM..........WA.-PAIAVTVTAAAGHTAHIYTADCRCdepdhd.............hgpdfpdDLMYQAICPPCS.WH.....-HIAA......NENA..AVEAW..HDHALPGW.RNLPVVprrvaqlDDTRATRQRRDRWVAE---HY...PEHWQRPGYPILTERGKW.....GT.RHVSGRSPFG.GYDLT---------gsvg...........
A0A1Q9TLM6_9ACTN/5-144 ......vttpitgcrvsvvsvlrdeye-----------------....-----------.........-----..........--.------------------------Plhet.................etslfHLRYWSTCPTCG.HT.....GPYRT......DENE..AAEDG..HDHAFPGW.RNLPVMg.....aRPYHEHRGACAAWEADALRVY...PQGWFEAAGPILTERPGG.....GT.RHVPGRAPGG.GFDIGIPTPTRR--ps.............
A0A059W6L8_STRA9/10-177 ...........................GAVARHTAYL--PQFWD....KSTSSRPIWRI.........DWGHP..........--.GFTHRTPPEPTASHQPTVLVRSWDQpapdg................sdqnwPYLHRGACLGCT.WE.....GPDRR......RTDE..AVEDA..HDHTHPGW.RELPAV.......-----PERQGRRWLTHVQHLY...PDGWLDQGGPVRTVRTGI.....EK.RHRPGAAPGG.GYDLAVQPPRRKD-r..............
A0A161V2K1_9NOCA/30-215 ...........................GVPSLFAS-T----TRGp..aARLAEFHAWQStwgn.fdsyRTSHA..........LI.-PGTCEPSQPTATCQPTSLWAGLHCsctwtlr...........ektchcvgGNLHRAACTGCD.WE.....GENRA......DSDE..AVCDA..LDHAHPGWlDDLAIE.......-IPDRPHEKTARWSTKVTAMIgdrPQGW-----PVITRRAEGh...vGN.RCVPDRSPWG.GYDVAAAVARAH--ld.............
A0A117RN59_9ACTN/10-192 ...........................GARARQTHYWRVRNARTr..qPPASAGRAWHI.........QPGHP..........GGaYCDLGHQLDPPAHHAPTLLSRSRPTgr.....................rgdEQEFRGGCLSCD.WE.....GPVHRgggygdGDNE..AVEDA..HDHAFPGW.RTLPSIt....kvEDRWAVLQSRSRW-AQFTSQY...PAGWIDQGAPIVAWSRYR.....RE.AHAPPHASRP.HYELRITRPPSN--rr.............
A0A1Q5LKB5_9ACTN/10-192 ...........................GARARQTYYWRVRNARTp..qPPMSAGHVWHI.........QPGHP..........GGaYCDLGHELEPPSHHTPTLLSRSRPTgr.....................rgyEQEFRGGCLACD.WE.....GPVYSgdgfgdGDNE..AVEDA..HDHCFPGW.RTLPPIt....tvEDRWAVPRSRSRW-AQLIAQY...PAGWVDQGAPVVAWRRYR.....RE.AHAPPHAGRP.RYELRITRPPRDR-v..............
A0A1U9ZXZ9_9ACTN/12-175 ...........................GAVARQLHYRTLADKQT....------GAWAI.........YITHP..........GNqLGRAHEPLELADTHLPTVLFQVGRH..........................PHRFRGACLGCD.WE.....S-DRD......DTNVlqAVEAA..HDHTHTGW.RTMPAV.......-HPQPPAGRASTWAKQVTAAY...PDGWFARGGPVLTIRPGP.....ADrRPLPGRAPGGrGYDLPAPASTRA--pa.............
A0A7X6CWP3_9ACTN/10-191 ...........................GARARQTYYWRVRNARTr..hRPESSAHRWHI.........QPGHP..........GGaYSDLGHELEPPAHHAPTLLSRSRPKpr......................ghEQQFRGGCLTCA.WE.....GPVYPgsghgdGDNS..AIEDA..HDHAFPGW.RELPPIt....raRDRRQTQRNLTRW-TQLTSQY...PLGWVDQGAPILVWSRHR.....RE.PHLPPHRGSP.RYELRVDRPPTHR-d..............
V8D3X3_9NOCA/28-209 ....yafesddladydrvfdqwqqdwg---------------RF....NSIAQSHAWRF.........AISDS..........FY.------RPRPLSGCQPVIMHASTSChhhrwte...........rcmcvgayNSPFRARCRGCT.WR.....SELVA......TETD..AVLAA..LDHTHPGW.RQSPIV......gSRPFDGTKKQQRWDDEVAGLYgdrPDGW-----PIITARPGD.....GD.RAVPGRSPWG.GYDIDARSL-----tppa...........
A0A646KVR5_STRJU/9-189 ...........................GARARQTYYWQVRNARHq.dlRAVHACETWHI.........RYGHP..........GGaYSDLGHDTVPPSHHSPTLLTRRMYGr........................pGDEYRGGCLSCL.WE.....GRPHTgggsnrALNC..AVEDA..HDHAFPGW.RDLPVVp....dlKSSGSPYGSQRLW-RQTADLY...PADWLDRGAPRLVRARRR.....GD.AHDPPSLSSP.RYELRVASPRRQE-r..............
A0A6G7YGB3_9ACTN/27-216 ...........................GAPLGFTA--AYWPA-V....DLEAAHEHWQFlhkl.dqsrTQSRM..........WH.RAIAVPGSVAVGEHGFDLFTADLRCepwthgea..........hggcqcvgDLIYQAICEPDG.WH.....-VIAG......DENT..AVEGW..HDHAFPGW.RELPIVpar.lrsVDQPGLSKAAKKWIAE---HY...PPPMQVVGAPVITERSNG.....GT.RHVPGRSPWA.GYDISHTAVEP---nlr............
A0A3P5XEL9_9MICC/24-207 ...........................GAPLAYTT-SYYSPA--....ELDAAFDRYRAefgg.fgciPRSHMw........hRN.SYNQGERAATDDGHELHMFYADAWCkesdhdh............tadplpgGGRYQAVCPGCA.WH.....-IITE......REND..AVEAW..HDHALPGW.RSLPIMprpaaaaTDEKKARAAAAKW---CAANY...PAEWQRPGSPVRTIRGPH.....GG.RHVESRSPFG.GYDLAA--------d..............
A0A0N1NUJ0_9ACTN/6-170 ...........................GAIARQRHYTSLRNA--....DREVLRATWSI.........GYGDP..........GF.STHLGTPPEPSTRHTATSIHKIVTD.........................aLWLHRGACLACS.WE.....GPDRR......RRDT..AIEDA..HDHTHPGW.RNLPIF.......-DRAGSGKGSKVWWAHVRATY...PQGWFDAGGPLRLYAEPP.....FD.RHAVGAAPGG.GFVLDTPRRKRQA-s..............
A0A4V0Z1F7_9MICO/1-95 .........................ms-----------------....-----------.........-----..........--.-------------------------..........................------------.--.....----N......TEND..VVEAW..HDHGVPGW.RELPIIpaqirvsDGSGGLTKIARAWIAK---HY...PTHMQIPGAPIITERARY.....AT.RHVNGRSPWG.GYDIASVALDR---sdp............
A0A7K1ULY0_9MICC/29-210 ..........................d-APLHFTS-EYYSPH--....ELEEAFAHWTFlngn.fdsyRRSHM..........WH.RGIAHEQQTVLGDHSGEMFSADLRSdrgh..................lgpgELLAQMICEPCD.WH.....-VITA......DENA..AVEAW..HDHALPGW.RALPVVpaq.ikvRHESGLTTVAKTWIAE---RY...PADMQVHGAPIITERSPV.....GT.RHVPSYSPWG.GYDLSSTALDT---paa............
A0A2N9JCP2_9ACTN/27-224 .........................rc--PLRYTT-DFYTPA--....ELDAALARWNA.........QYGNFgsy....pfsHMwHPAIASKPLLLEHHQLHLYHADGRCdlhlygtaspgrdqanhdhtqqplpgSTMSQAICTSCR.WH.....-HIDP......DESA..AVEAW..HDHAMPGW.RSLPVMpn...kiRVTRHGPHGTKKIAEWVQAHY...PPHWLIDGAPILTERNPK.....GT.RAVPGYSPLG.GYDITAPAAKA---t..............
A0A7H8NAJ3_9ACTN/10-192 ...........................GARARQTYYWRVRNARTr..rHPESAGQTWHI.........QPGHP..........GGaYSDLGHELDPPPHHTPTLLARSRPTsr.....................rgdEREFRGGCLACA.WE.....GPVHFgdglgdGDNE..AVEDA..HDHAFPGW.RTLPPIt....tvKDRWAVPRSRNRW-AQLAARY...PADWIDQGAPVVAWSRYR.....RE.AHAPPHAGRP.RYELRVPRPTV---drg............
A0A061LZA2_9MICO/28-208 ...........................GAPLHFTT-DYYPPA--....MLDEAFAHWRFlngd.fgsfGRSHM..........W-.HRSISGGTVEFGEHRAESFTADLRPepga..................egpgDLLTMVVCEPCE.WH.....S-PAG......SENE..AVEAW..HDHAVPGW.RELPVVprq.vrvRSETGLTKVALRWIEQ---RY...PAHMQVPGAPIITERAQY.....GT.RHVAGYSPWG.GYDLSATALERP--ar.............
A0A0A8EX43_9ACTN/10-177 ...........................GAVARHTAYLPHFWD--....KATNSRPIWRI.........DWGQP..........--.GFTQRTPPDLTADHRPTVLARSWDRpapdg................tgetwPYLHRGACLGCT.WE.....GPDRR......RTDE..AVEDA..HDHTHPGW.RDLPAV.......-----PEHQGRRWLTHVQHLY...PDGWFDRGGPVRTVRTGI.....EK.RHRPGAAPGG.GYDLGVQPPRRN--dp.............
A0A4Y3USK0_9MICO/30-211 ...........................GAPLRFTQ-DYYPPA--....AIDEAFDHWVFingh.hgshARSHM..........WH.RMMWNAGAVEFGDHRGEMFSAELRPehgq..................egpgGLLEQMVCEPCQ.WH.....A-IDE......DENS..VVEQW..HDHAVPGW.RELPVVpas.vrvRDGSKMTKLALAW---IRERY...PEHMQVPGAPIITERQPY.....GT.RHVAGYSPWN.GYDLSHTALD----cpar...........
#=GC seq_cons ...........................GA.h+.Tt..hh.ss......t.psuhttWph.........thuH...........h..h.shsptstssspHpsshhstshpstt......................stshhapusChsCs.Wc.....ushps......s-sp..AVEst..HDHAaPGW.RsLPsls.....h.sphtsp+ptpcWhsph.tpY...PssW.p.GuPllThRsth.....us.RHlPupuPhG.GYDLssst.t....st.............
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