#=GF ID   DUF6354
#=GF AC   PF19881.3
#=GF DE   Family of unknown function (DUF6354)
#=GF AU   Williams LS;0000-0001-5551-8526
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Fragoso S;0000-0001-7018-3891
#=GF SE   Manual
#=GF GA   25.00 25.00;
#=GF TC   25.20 25.10;
#=GF NC   23.30 23.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   28111097
#=GF RT   An Unusual Protector-Protege Strategy for the Biosynthesis of
#=GF RT   Purine Nucleoside Antibiotics.
#=GF RA   Wu P, Wan D, Xu G, Wang G, Ma H, Wang T, Gao Y, Qi J, Chen X,
#=GF RA   Zhu J, Li YQ, Deng Z, Chen W;
#=GF RL   Cell Chem Biol. 2017;24:171-181.
#=GF DR   INTERPRO; IPR045934;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents a member of a biosynthetic gene cluster
#=GF CC   (BGC). This BGC (BGC0001735) is described by MIBiG as an example
#=GF CC   of the following biosynthetic class, other (unspecified), in
#=GF CC   particular  the pentostatine biosynthetic gene cluster from
#=GF CC   Streptomyces  antibioticus [1].
#=GF SQ   11
#=GS D9VKV3_9ACTN/1-124        AC D9VKV3.1
#=GS A0A7W7WAR8_9ACTN/1-77     AC A0A7W7WAR8.1
#=GS A0A6H0CZU6_9ACTN/1-111    AC A0A6H0CZU6.1
#=GS A0A0M9ZLI4_9ACTN/1-122    AC A0A0M9ZLI4.1
#=GS A0A1Z2LE79_9ACTN/10-94    AC A0A1Z2LE79.1
#=GS A0A7Z0PRW3_9ACTN/1-76     AC A0A7Z0PRW3.1
#=GS A0A6I4MXW9_9ACTN/156-237  AC A0A6I4MXW9.1
#=GS A0A1V2RLB1_9ACTN/1-117    AC A0A1V2RLB1.1
#=GS A0A1D2I735_9ACTN/1-122    AC A0A1D2I735.1
#=GS A0A3N6FEI9_9ACTN/1-111    AC A0A3N6FEI9.1
#=GS A0A0M8QV29_9ACTN/1-122    AC A0A0M8QV29.1
D9VKV3_9ACTN/1-124                   ..........mlpgrtwal----RAGRGHMAGTVTEGQLYRDLAPDMRARDRRLRVVEV..G.NARARL.VVEHDL...G....GTG.....GKTTH.ASLVRL..AS..RAFELVEDAID--EDPHYLTVLAAISAVHHPD..TSPADYTRAALRAL...RTP--rt......
A0A7W7WAR8_9ACTN/1-77                ................mae-----------IPDVRPGQVWADN--DKRAAGRKVRVVEI..D.GTHA-V.VVQVDA...R....GVVdsrmrERRTR.IRLDRFkpTS..TGYRLVTDV-----------------------..--------------...-----pt......
A0A6H0CZU6_9ACTN/1-111               ..................m---------------AEGQLCRDLDRYMAGRDRRLRVGPI..GpDGRAAC.VVEHDLhqgG....ALV.....GRTTP.NHVDNL..AN.pRKFELLEDTDAVAADPRYTRLLSAMAAVHGPA..ATPRDYARAAYDAL...-----gleg....
A0A0M9ZLI4_9ACTN/1-122               ...................MSTSPSPVSSAVGPVRVGQLWQDMAPDMVDRERMLRVLAL..T.DTHAEC.VVERDR...Q....GTA.....GRKARpLAIRRF..AT..SAFKLIEDVVDDADQALYARFLAAMTGVQGAN..PSPVAYAAAALRVH...HELTA........
A0A1Z2LE79_9ACTN/10-94               ............irqpgap------GTAATGGPVGPGQLYLDLASGRD--DRRVRVIMVeeN.GVLAAC.RVERDL...S....GLAd..vfGRTPR.IHVRAL..AD.pRRFALLEDP-----------------------..--------------...-----r.......
A0A7Z0PRW3_9ACTN/1-76                ...............mttp-------------APAVGQLWQDNDPR--SYGRKVRIVEI..D.DTHATV.ELHQPR...QpvssAKP.....GRRTR.IRLDRF..RPtsTGYRYV--------------------------..--------------...-----geats...
A0A6I4MXW9_9ACTN/156-237             qgralraqrealrrienpp--------------PAVGQIWQDTDPR--SHGRTVRIVEV..S.DTHALIeLHERLG...N....ETP.....GRRTR.VRLHRF..RP..--------------------------------..--------------...-----rrgyrylg
A0A1V2RLB1_9ACTN/1-117               .................ms------------RSIEKGQLYRDLDRYMANRDRRLRVTGV..G.DTRAEC.LIEHDL...G....GTV.....GRTTH.IQLKAL..AT.pSKYELLEEAETLGADPRYAALLSAMAKVHGAGsaATPLDYANAAWDALglaQQE--ta......
A0A1D2I735_9ACTN/1-122               ...................MSTSPSPVSSAVGPVRVGQLWQDMAPDMVDRERMLRVLAL..T.DTHAEC.VVERDK...Q....GTA.....GRKARpLAIRRF..AT..RAFKLIEDVVDDADQALYARFLAAMTDVQGAN..PSPVAYATAALRVH...HELTA........
A0A3N6FEI9_9ACTN/1-111               .................mm----------VRPAVAEGQLYRDLAPDMKKRQRQLRVVAT..T.ATHAKL.IAEHDL...G....RKA.....GYTTT.ASLARL..GS..SAFELMEDPAD--TDPLYLALLSAMSRAHRPG..ATPADYARAALTVI...RTTE-q.......
A0A0M8QV29_9ACTN/1-122               ...................MSTSPSPAPSTVGRVRAGQLWQDMAPDMVARERILRVTDV..N.ETHAEC.VVERDK...Q....GTA.....GRKTRpLALKRF..AT..SAFKLIEDVVDDADQPLYARFLAAMTAVQGTS..PSPMEYATAALRVH...QEVI-a.......
#=GC seq_cons                        ..............................hssVtsGQLapDhsPcMhsR-RpLRVltl..s.-THAps.lVE+Dh...p....Gss.....GRpTR.lpLcRh..Ao..puFcLlEDs.s..tpshYhthLuAhstsptss..soPhtYstAAhpsh........t.......
//