#=GF ID DUF6374
#=GF AC PF19901.3
#=GF DE Family of unknown function (DUF6374)
#=GF AU Williams LS;0000-0001-5551-8526
#=GF AU Finn RD;0000-0001-8626-2148
#=GF AU Fragoso S;0000-0001-7018-3891
#=GF SE Manual
#=GF GA 25.00 25.00;
#=GF TC 25.10 25.60;
#=GF NC 24.70 22.20;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF WK Domain_of_unknown_function
#=GF RN [1]
#=GF RM 30867595
#=GF RT Enzyme-catalysed [6+4] cycloadditions in the biosynthesis of
#=GF RT natural products.
#=GF RA Zhang B, Wang KB, Wang W, Wang X, Liu F, Zhu J, Shi J, Li LY,
#=GF RA Han H, Xu K, Qiao HY, Zhang X, Jiao RH, Houk KN, Liang Y, Tan
#=GF RA RX, Ge HM;
#=GF RL Nature. 2019;568:122-126.
#=GF DR INTERPRO; IPR045954;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This entry represents a member of a biosynthetic gene cluster
#=GF CC (BGC). This BGC (BGC0002024) is described by MIBiG as an example
#=GF CC of the following biosynthetic class, polyketide, in particular
#=GF CC the nargenicin biosynthetic gene cluster from Nocardia
#=GF CC argentinensis [1].
#=GF SQ 29
#=GS A0A7K0DNB7_9NOCA/1-59 AC A0A7K0DNB7.1
#=GS A0A3M2LA57_9NOCA/2-60 AC A0A3M2LA57.1
#=GS A0A318K6X9_9NOCA/1-59 AC A0A318K6X9.1
#=GS A0A318JUP5_9NOCA/7-59 AC A0A318JUP5.1
#=GS A0A231GUH8_9NOCA/1-58 AC A0A231GUH8.1
#=GS A0A7K0CWG6_9NOCA/10-67 AC A0A7K0CWG6.1
#=GS A0A231HF88_9NOCA/1-58 AC A0A231HF88.1
#=GS A0A6I2FW31_9NOCA/1-58 AC A0A6I2FW31.1
#=GS A0A7K0DU52_9NOCA/1-59 AC A0A7K0DU52.1
#=GS A0A846XQ89_9NOCA/1-59 AC A0A846XQ89.1
#=GS A0A4V3CME4_NOCIG/1-54 AC A0A4V3CME4.1
#=GS A0A6I3L6N7_9NOCA/1-58 AC A0A6I3L6N7.1
#=GS A0A370I526_9NOCA/10-68 AC A0A370I526.1
#=GS U5EAF6_NOCAS/1-59 AC U5EAF6.1
#=GS A0A6G9YBB3_9NOCA/1-54 AC A0A6G9YBB3.1
#=GS A0A7W9PDD3_9NOCA/1-59 AC A0A7W9PDD3.1
#=GS A0A379JNB9_9NOCA/1-57 AC A0A379JNB9.1
#=GS A0A7G1KBA2_9NOCA/1-59 AC A0A7G1KBA2.1
#=GS A0A164HE06_9NOCA/1-59 AC A0A164HE06.1
#=GS A0A164K7S5_9NOCA/1-48 AC A0A164K7S5.1
#=GS A0A849CBQ1_9NOCA/1-60 AC A0A849CBQ1.1
#=GS A0A1V2TGH7_9NOCA/25-83 AC A0A1V2TGH7.1
#=GS A0A378YFJ9_9NOCA/1-59 AC A0A378YFJ9.1
#=GS A0A7X6L344_9NOCA/1-59 AC A0A7X6L344.1
#=GS A0A0B8N938_9NOCA/1-58 AC A0A0B8N938.1
#=GS K0F577_NOCBR/1-59 AC K0F577.1
#=GS A0A370GJG3_9NOCA/1-59 AC A0A370GJG3.1
#=GS A0A7D6VN18_9NOCA/1-56 AC A0A7D6VN18.1
#=GS A0A4R6NWN1_NOCIG/1-43 AC A0A4R6NWN1.1
A0A7K0DNB7_9NOCA/1-59 ....MPLDRHLQFAQLWLEQVRDNLATAAATGTPVPPEQLNIMSGKIAAGLRVFSELAEHRP-h.....
A0A3M2LA57_9NOCA/2-60 ....SPAERRIRFAQQWLEQVRDHLADAGAQGSPLSPEQLNILSGKVAGGLEIFVAETRAVS-h.....
A0A318K6X9_9NOCA/1-59 ....MSPLSRKDWAKMNLEQVRDQLLDAAAFGKYLPPEQLENAAGKIAEGLRVYQELTC----dqge..
A0A318JUP5_9NOCA/7-59 atdv----TRVATARARIANVRRRLLDTAAFGKSLTPDQLEHLAAELGETLRVLT--------dd....
A0A231GUH8_9NOCA/1-58 ..md---LSRLEWARMNLEQVRAQLLDAAAFAKYLPPEQLERAAWKIGEGLRIYREETEPA--da....
A0A7K0CWG6_9NOCA/10-67 ....MPLDRH-HLAHLWLEQVRDHLAQAATTNTPLPPEQLNIMSGKVAAGLQILTEPTHPD--eh....
A0A231HF88_9NOCA/1-58 ..me---LTPLEYARLNLEQVRAQLVDAAAFDKALTPDQLERAAWKIREGLRIYREHTESP--rv....
A0A6I2FW31_9NOCA/1-58 ....MPELSRHEWATMNLEQVRRQLLDAAAFGKYMTPEQLENAAGKIGEGLRIFREETDHP--r.....
A0A7K0DU52_9NOCA/1-59 ....MSEPARIPDAYQQIDQVRRQLVEAAAFSKHLTPDALEHLAGTLATGLRLIADHTTA---spv...
A0A846XQ89_9NOCA/1-59 ....MPELAPIPFARLNLEQVRERLLAAAAFGESLSPDQLEALAGKLSAGLNIYIEATQNSS-r.....
A0A4V3CME4_NOCIG/1-54 ....MAQTSRPDWTAAALAALRRQVLDATAFGAVVHPAQVEAITARLDAHLR-----------arlrhd
A0A6I3L6N7_9NOCA/1-58 ....MPELSRRDWATMNLKEVQRQLLKAASFGKALSPEQLENAAGKIGEGLRIFLEEMDQ---tg....
A0A370I526_9NOCA/10-68 ....MPPDRHIQFAQLWLEQVRDRLASAAATSDPLGPEQLNILSGKVAEGLRIFTELTEHHR-s.....
U5EAF6_NOCAS/1-59 ....MSEMPAPAPTAAALATVRRQLGVCAAFGAVAAPEQLDEIAERLTEVLRGYAVADTRRY-p.....
A0A6G9YBB3_9NOCA/1-54 ....MLERSRISLAQTQIDNVRRQLLDAAAFGKRITPDQLEHLAAKLGDSLRILTEE------p.....
A0A7W9PDD3_9NOCA/1-59 ....MPLDRHIHFAQLWLEQVRDHLASAAATSTNLSAEQLNVMSGKVAEGLRIFTELADQPP-a.....
A0A379JNB9_9NOCA/1-57 ....MPELDRRDWAALNLRQVCAQLLDAAAFGKYLTPEQLEHAAGKVGEGLRVFLEETER---s.....
A0A7G1KBA2_9NOCA/1-59 ....MPLDRHIQFAQLWLEQVRDHLASAAATSSPLTAEQLSVMSGKVTEGLRVFTELAAT---ttn...
A0A164HE06_9NOCA/1-59 ....MPLERHVQFAQLWLEQVRDRLAEAGATSASLPPEQLNILSGKVAEGLRIFIEATHEPP-a.....
A0A164K7S5_9NOCA/1-48 ....-----------MNLEQVRSQLLDAAAFGKYLPPEQLENAAGKIAEGLRIFLEETQHL--aq....
A0A849CBQ1_9NOCA/1-60 ....MPDLDPVAIAHMQLNDVRRQLLDAAAFGKLTPPEWLEHMAGRVADGLRIYTAAL-----dsrtpe
A0A1V2TGH7_9NOCA/25-83 ....MPELAPIPFARMNLEQVRERLLAAAAFGETLSPDQLEALARKVTAGLRIYIQATQNGA-r.....
A0A378YFJ9_9NOCA/1-59 ....MPELSRLDWARMNLDQVRRQLLDAAAFGKYITPEQLEHAAGKIAEGMRIYLEETHPTP-a.....
A0A7X6L344_9NOCA/1-59 ....MPDLEPTQFAYSQINAVRRQLLDAAAFGKHLRPEHLENMAGKLAEGLRAYTEAMTPT--tp....
A0A0B8N938_9NOCA/1-58 ....MPELSRRDWATMNLQEVQRQLLKAASFGKVLSPEQLENAAGKIGEGLRIFLEETDH---ls....
K0F577_NOCBR/1-59 ....MSQPSRREWATWNLEQVRDQLLDAAACGKRLPPEQLEQAAGKIGEGLRVFQELTRGAA-e.....
A0A370GJG3_9NOCA/1-59 ....MPLDRHIHLAQLWLEQVRDHLASSAATSTNLSAEQLNVMSGKVAEGLRIFTELAGQPS-t.....
A0A7D6VN18_9NOCA/1-56 ....MPELSRLEWAHMNLDQVRRQLLDAAAWGKYITPEQLEHAAGKIAEGMRIYREE------ige...
A0A4R6NWN1_NOCIG/1-43 ....MAQTSRPDWTAAALTALRRQVLDATAFGVLVHPTQVY----------------------aitacl
#=GC seq_cons ....MP..s+hpaAphpL-QVRcQLL-AAAFGchLsPEQLEthAGKluEGLRIatEtspt...s.....
//
