#=GF ID   DUF6375
#=GF AC   PF19902.3
#=GF DE   Family of unknown function (DUF6375)
#=GF AU   Williams LS;0000-0001-5551-8526
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Fragoso S;0000-0001-7018-3891
#=GF SE   Manual
#=GF GA   27.50 27.50;
#=GF TC   28.30 28.30;
#=GF NC   27.10 26.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   21180767
#=GF RT   Identification of the gene cluster involved in muraymycin
#=GF RT   biosynthesis from Streptomyces sp. NRRL 30471.
#=GF RA   Cheng L, Chen W, Zhai L, Xu D, Huang T, Lin S, Zhou X, Deng Z;
#=GF RL   Mol Biosyst. 2011;7:920-927.
#=GF DR   INTERPRO; IPR045955;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents a member of a biosynthetic gene cluster
#=GF CC   (BGC). This BGC (BGC0001020) is described by MIBiG as an example
#=GF CC   of the following biosynthetic classes, NRP (non-ribosomal
#=GF CC   peptide) and polyketide, in particular the muraymycin C1
#=GF CC   biosynthetic gene  cluster from Streptomyces sp. NRRL 30471 [1].
#=GF SQ   20
#=GS A0A840VE79_9BACT/1-126  AC A0A840VE79.1
#=GS B4DAN9_9BACT/1-66       AC B4DAN9.1
#=GS A0A1H0R8I0_9ACTN/1-132  AC A0A1H0R8I0.1
#=GS W7TFP4_9PSEU/1-132      AC W7TFP4.1
#=GS A0A239P6X2_9ACTN/1-132  AC A0A239P6X2.1
#=GS A0A2R5H746_9MYCO/1-134  AC A0A2R5H746.1
#=GS A0A1R4JZF9_9ACTN/1-67   AC A0A1R4JZF9.1
#=GS A0A8J3B3D2_9ACTN/1-134  AC A0A8J3B3D2.1
#=GS A0A5D0NHQ3_9ACTN/1-132  AC A0A5D0NHQ3.1
#=GS A0A6B2XEI8_9ACTN/1-134  AC A0A6B2XEI8.1
#=GS W0HVG2_9GAMM/1-134      AC W0HVG2.1
#=GS A0A6M8UIP5_9GAMM/1-134  AC A0A6M8UIP5.1
#=GS A0A545AND3_9ACTN/1-99   AC A0A545AND3.1
#=GS L0A7K0_DEIPD/1-131      AC L0A7K0.1
#=GS A0A7L4XXS6_9ACTN/1-132  AC A0A7L4XXS6.1
#=GS A0A505DJV5_9ACTN/1-132  AC A0A505DJV5.1
#=GS A0A6G4TRE8_9ACTN/1-134  AC A0A6G4TRE8.1
#=GS A0A5B8SWK5_9GAMM/1-134  AC A0A5B8SWK5.1
#=GS U1JVW7_9GAMM/1-128      AC U1JVW7.1
#=GS A0A7S8EB35_9CHLR/1-65   AC A0A7S8EB35.1
A0A840VE79_9BACT/1-126             ...MKIWNAYGSEHSMNLVMIGCFKDAGAAEAAKDAIEELQAYFSE.HDP--------DGEIYTREVMDLLSRCKVSTVAATELEQFRYDFSVNTDGQNVLIKTDEADVSAICKLLIDRGAKVQIYSKHDYPEE----vdsg.................
B4DAN9_9BACT/1-66                  ...MKIWYATSAEHSAALTIVGTFHREEDAQAAEALLKGMIQTATQaEVEVEPLRHQE--------------------------------------------------------------------------------meahsaavlaa..........
A0A1H0R8I0_9ACTN/1-132             ...MKIWNGYGSEHSMDLVLIGRFQTVTGAQAAAEGMEALRALAEA.AWSDDDWRS--HDERMPLELVDELVKLKLYDLGRPDVDIYALDHSITREAETVRVWTEESDVQGFLKVLLHYGAKVEVFSRHAWNEDGSE-r....................
W7TFP4_9PSEU/1-132                 ...MRIWNGYGSEHSMNLVLIGRFQTITGAKAAEERMEALQALAED.KWSDDDWRS--PDERMPRELGQALAEMKLYDMGRHDVDVFALDHSVTRTAETVRIWTDESDVQGFLKVLLHYGARVEVYSRHEWDEDAIA-r....................
A0A239P6X2_9ACTN/1-132             ...MKIWHSYGSEHSMDLVLIGKFETVSGAEAAIERMEALKALAEA.EWSDDDWRL--PEKRMPDALVDELMKLKLYELGRSDVDIYAFDHSVERDGSTIHIWTEESEVQGFLKVLLHLGARVEVFSRHDWNDDGTP-r....................
A0A2R5H746_9MYCO/1-134             ...MKIWYGFGTEHSMDLVMIGRFQDVASAQTAKEVIEKLAAAIRI.EEKEDRLIVGEHTDRYSEDLLDLLIELGIHNVKPDELEQFLYDVNVRRRGDSIVITTDEIDVQAFLKIMLNKGARVEVYSRHQHPDSDP--vd...................
A0A1R4JZF9_9ACTN/1-67              .ms-------------------------------------------.-------------------------EVSIHSLGYADVEQFLYDTEIDVKGSRVVVQTDEIDVIAYIKVLLAKGAKVEMYSGHDHDT-----gvgg.................
A0A8J3B3D2_9ACTN/1-134             ...MRIWWGYGSEHSMNLVMIGRFASVGEAESAKELIDKLATGVQA.EVDAGRLEVGEPTRRFSQEMIDLLTELNLHALSPGDLEQLVYDTQIRVHGDSVVIRTDEVDVAAHMKILLDRKARIEIFSAHVHEAEG---dal..................
A0A5D0NHQ3_9ACTN/1-132             ...MRIWHSYGSEHSMDLVLIGTFETVAGAEAAMERMEALKPLGEA.EWPDNDWRR--QDERMPTALADELMKLELYDMGRSDVDIYGYDYSIERNGSTVRIRTEESEVQGFLKVLIHLGARVEVFSRHDWNEDGTP-r....................
A0A6B2XEI8_9ACTN/1-134             ...MKIWSGYGTEHSMNLVMIGRFKDATTAERAHDLIKELTKALQK.EKEAGRLTIGEPNDSYSDEVLELLSDLNIHSIGPRELEQFLYDLTLRRDGDSIVVTTDETDVQALLKVLLDKGARIEVYSAHDYPGTGHG-r....................
W0HVG2_9GAMM/1-134                 ...MKIWNGYGSEHSMNLVLIGKFKQEQDAEKVEKDIKTLSTQAEK.DECYSIPFDEPENQRFSDEMLSLLCSLKLHTLGPTDLGQLVSDHHLDREGDRITITTDEAEVSAFVKLFVEAGAKVEIFSAHDYPSDSSD-a....................
A0A6M8UIP5_9GAMM/1-134             ...MKIWNGYGSEHSMNLVLIGKFKQEQDAEKVEKDIKTLSTQAEK.DECYSIPFDEPENQRFSDEMLSLLYSLKLHTLGPTDLGQLVSDHHLDREGDRITITTDEAEVSAFVKLFVEAGAKVEIFSAHDYPSDSND-a....................
A0A545AND3_9ACTN/1-99              ...---------------------------------METLRRLADG.VWSSDDWQQ--QDERMPREIIDKLATLGLYDMGRNDLDNYAFTHDVDRRESTVRIRTEESEIQGFIKLLLHHGGKVEVLSRHNWNDDGTA-k....................
L0A7K0_DEIPD/1-131                 ...MKVWQGYGSEHSMNLVMVGTFKTEADANKVREAIQQITRQVDI.AVDKGILEVGENNREFGEDLRQLLHQLNLYILNPHEMEQFRYDVSLEAKDRCLVLTTDEIDVSAFMKIFVDKGAG---WSPLSGPAESRG-k....................
A0A7L4XXS6_9ACTN/1-132             ...MRIWNGYGSEHSMNLILIGQFQTVAEARAVTERMKALEALAEA.EWSDDDWRS--RDERMPPEISKALYDMQLYDMGRSDVDAYALDHRVTRDGEKIRIWTDDTEIQGFLKVLLHHGAKVEIFSRHNWDGDA---npi..................
A0A505DJV5_9ACTN/1-132             ...MRIWHSYGSEHSMDLVLIGTFETVSGAEAAMERMEALKTLAEA.EWSDNDWLR--ADERMPRALADELGKLRLYDMGRSDVDIYALDHSVQRTGSTVRVWTEESEVQGFVKVLVNLGARVEVFSRHHWNEDGTP-r....................
A0A6G4TRE8_9ACTN/1-134             ...MKIWYGFGTEHSTNLVMIGRFKDAATTERAHALIKEITTVLQA.EEEAGRLTVGEPKDRYSDEVLKLLTDLNIYSVGSRELEQFLYDLTVRRDGNSIVVTTDEIDVQALLKVLLHKGARIEVYSAHNYPGTGHG-r....................
A0A5B8SWK5_9GAMM/1-134             ...MKIWNGYGSEHSMNLVLIGSFKGAQDAEKVENNIEKLSAQSLK.DDSCSITFADPENQRFSDDMLSLLWSLNLHTLGPSELGQLVSDHHFAREGSRITVTTDEADVSAFVKLFIEAGAKVEVFSAHDYPTDSD--da...................
U1JVW7_9GAMM/1-128                 ...MKIWTSYGAEHSLNLVIIGHFKDAIEAEEFESLVSSLTNFLVN.DSDFDV-----DSDRFSSGMLDYLGKKNLFCLSPQQLGQLLYDMRLEREENKIVISSDD-DLNALTSLLIHSGAKVEMFSAHDHPHEEHGR.....................
A0A7S8EB35_9CHLR/1-65              mki-SIWQQFGSNHSSDFTVVGTFKSVSDAEQAAQTLLEIFGYIV-.-------------------------------------------------------------------------------------------eqridiydaklvpaevwyaeq
#=GC seq_cons                      ...MKIWpuYGSEHSMsLVlIGpFcssssAEtAcctlcpLpshspt.-.sss.hh...tscRhsc-lhchLhcLpLaslG.s-l-pahhDhplcRcGsslhlpTDEs-VpuFlKlLlctGA+VElaStHsass-up..c....................
//