#=GF ID DUF6399
#=GF AC PF19936.3
#=GF DE Family of unknown function (DUF6399)
#=GF AU Williams LS;0000-0001-5551-8526
#=GF AU Finn RD;0000-0001-8626-2148
#=GF AU Fragoso S;0000-0001-7018-3891
#=GF SE Manual
#=GF GA 35.40 35.40;
#=GF TC 36.00 36.00;
#=GF NC 35.30 35.20;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP Family
#=GF WK Domain_of_unknown_function
#=GF RN [1]
#=GF RM 24974231
#=GF RT Calyculin biogenesis from a pyrophosphate protoxin produced by a
#=GF RT sponge symbiont.
#=GF RA Wakimoto T, Egami Y, Nakashima Y, Wakimoto Y, Mori T, Awakawa T,
#=GF RA Ito T, Kenmoku H, Asakawa Y, Piel J, Abe I;
#=GF RL Nat Chem Biol. 2014;10:648-655.
#=GF DR INTERPRO; IPR045650;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This entry represents a member of a biosynthetic gene cluster
#=GF CC (BGC). This BGC (BGC0000967) is described by MIBiG as an example
#=GF CC of the following biosynthetic classes, NRP (non-ribosomal
#=GF CC peptide) and polyketide, in particular the calyculin A
#=GF CC biosynthetic gene cluster from uncultured Candidatus
#=GF CC Entotheonella sp. [1]. This family appears to be predominantly
#=GF CC found in proteobacteria and cyanobacteria.
#=GF SQ 39
#=GS U9W277_9CYAN/227-372 AC U9W277.1
#=GS A0A1H6F913_9GAMM/2-69 AC A0A1H6F913.1
#=GS A0A1A8XRD3_9PROT/1-46 AC A0A1A8XRD3.1
#=GS A0A1V1NSD5_9DELT/29-108 AC A0A1V1NSD5.1
#=GS A0A8J7E3G7_9CYAN/1-85 AC A0A8J7E3G7.1
#=GS A0A1X1QSB2_9GAMM/322-467 AC A0A1X1QSB2.1
#=GS W4LN98_9BACT/202-347 AC W4LN98.1
#=GS A0A6M0K6F9_9GAMM/167-313 AC A0A6M0K6F9.1
#=GS F9UAP2_9GAMM/259-405 AC F9UAP2.1
#=GS A0A8J7AW12_9CYAN/1-85 AC A0A8J7AW12.1
#=GS A0A5K8AB23_9DELT/157-223 AC A0A5K8AB23.1
#=GS A0A6M0K6D0_9GAMM/383-529 AC A0A6M0K6D0.1
#=GS V4J588_9GAMM/89-219 AC V4J588.1
#=GS A0A5C2HM94_9GAMM/414-559 AC A0A5C2HM94.1
#=GS A0A2T1DDB5_9CYAN/183-298 AC A0A2T1DDB5.1
#=GS H8Z643_9GAMM/417-563 AC H8Z643.1
#=GS A0A080LYZ9_9PROT/43-156 AC A0A080LYZ9.1
#=GS A0A5C2HG59_9GAMM/414-559 AC A0A5C2HG59.1
#=GS A0A0N0V0B1_9DELT/1-137 AC A0A0N0V0B1.1
#=GS A0A2K8U438_9GAMM/400-546 AC A0A2K8U438.1
#=GS L8LTQ9_9CHRO/9-154 AC L8LTQ9.1
#=GS A0A853IBU3_9GAMM/119-259 AC A0A853IBU3.1
#=GS A0A8J7A9X8_9CYAN/1-100 AC A0A8J7A9X8.1
#=GS A0A1X1QNR5_9GAMM/39-184 AC A0A1X1QNR5.1
#=GS A0A1Z3HQR9_9CYAN/368-513 AC A0A1Z3HQR9.1
#=GS K9W4Z7_9CYAN/378-523 AC K9W4Z7.1
#=GS V4JJC7_9GAMM/1-74 AC V4JJC7.1
#=GS K9W250_9CYAN/157-302 AC K9W250.1
#=GS A0A080LWY0_9PROT/147-292 AC A0A080LWY0.1
#=GS A0A6N1Y9G0_9GAMM/2-37 AC A0A6N1Y9G0.1
#=GS A0A850SUQ8_9DELT/1-104 AC A0A850SUQ8.1
#=GS A7C2A3_9GAMM/1-124 AC A7C2A3.1
#=GS A0A2K8U5E6_9GAMM/400-546 AC A0A2K8U5E6.1
#=GS A0A1X1QV38_9GAMM/311-456 AC A0A1X1QV38.1
#=GS A0A850T4M3_9DELT/262-405 AC A0A850T4M3.1
#=GS A0A5C2HUS4_9GAMM/59-204 AC A0A5C2HUS4.1
#=GS F9UDR3_9GAMM/400-546 AC F9UDR3.1
#=GS A0A8J6XEW3_9CYAN/156-223 AC A0A8J6XEW3.1
#=GS A0A5C2HHN5_9GAMM/59-204 AC A0A5C2HHN5.1
U9W277_9CYAN/227-372 ..................v-LMALLPWVYWTQQADKTRQPALKHRYQQAASSTFDRLLE..QSITLQLDANELECWVLWCRDFCAKYQRTSSAVEGRNGYLSKLHHASRGFSEQSLKGLTIIHNFDLKRPDGTTAAQRLFGHPFPDVFEWILEHIGDLPMPRRSSK-t......
A0A1H6F913_9GAMM/2-69 ........lgmsyksrlll----------------------------------------..-------------------------------------------------ICHSRLKALMVLANYERQELDVKTSAEQFFDTSFLDIFDWVLDVMEILPLPQKRAK-r......
A0A1A8XRD3_9PROT/1-46 ...................----------------------------------------..------------------------------------------------------------MHNYHIRRADGTTAAQRFFGRAHETLFAQVLQRMPLPPRPARRRPR.......
A0A1V1NSD5_9DELT/29-108 ..................v-RETLIPGLYLRRISNQAKKSDERKRLKLKSSEILESLKGsnSPFN-GLNNEELEMIEQVGEECANLFQRTSSCVEGRNGQ-------------------------------------------------------------------.......
A0A8J7E3G7_9CYAN/1-85 ...................----------------------------------------..---------------------MCANYQRTSSAVEGRNGYLAQRHHASRGFSPQALSVLTILHNFDLKRPDGSTAAQRLFGHPFPDLFEAVLSTFTELPRPRQST--ss.....
A0A1X1QSB2_9GAMM/322-467 ..................v-IDALLPVVYWHHQLHKTQNRQLREKYQQAWKSSSAVLRQ..HPLTDALSVCKLQHWLTWAEWMVQHFHRSSSAVEGRNGSLSKMYHNGRGISESRLKALTVIHNYGLKRRDGTTAAQRFFEQDSPDLFSWILDEMGELPLPRQARP-k......
W4LN98_9BACT/202-347 ...................MDTLLLPLMYWQEQASHTREPRRKAEILKALKATQAAFEA..HTLTQYLSSDVLEGWKQWAMEHVRAFQRASSAVEGRNGYLSQMQHNHRGLPKRRYQVWSALHNFDCHAADGSTPASRFFRHEFPDLFETVLAQIDELPRPRERRQ-v......
A0A6M0K6F9_9GAMM/167-313 ...................MLDDLIPALYLERAVERRTRAEQRHRLKRLSAQRLAPLQQpeHPIQ-ALDRETRCHLEQVAQECADLFQRSSSCVEGRNGFLSLYQHGHHRLSPRKQAVLTAIHNFAIKRPDGTTAAERFFAKAHPPLFEQVLERMPWPARLAKRRP-r......
F9UAP2_9GAMM/259-405 ...................MLDDLIPALYLERVAARSTRAEPRHRLRALSAQRLAPLQQlsHPIQ-SLDPQTRHHLEQVAGECADLFQRSSSCVEGRNGFLALYQHGHHRLGPSKQQVLTALHNFAIKRPDGTTAAERFFAQPHPSLFEQVLERMPWPARPARRRP-r......
A0A8J7AW12_9CYAN/1-85 ...................----------------------------------------..---------------------MTAKYQRTSSAVEGRNGYLSQRHHVSRGFSEPALKSLTIIHNFDLKRPDGSTAAQRLFGHDFPDLFEWVLGNFTDLPMPRRSSQ-a......
A0A5K8AB23_9DELT/157-223 yadgrkgsdwmkamedalk----------------------------------------..----------------------------------------------------------AVVHNYFIKRRDETTPAERFFGAKPNDLFSFLLDKADIPRRPAKKR--fk.....
A0A6M0K6D0_9GAMM/383-529 ...................MLNDLIPALYLERAAARSTRAEQRHRLRALSAERLAPLQQpsHPIQ-SLDQETRCYLEQVAGECADLFQRSSSCVEGRNGFLALYQHGHHQLSPRKQQVLTALHNFAITRPDATTAAERFFAQPHPSLFEQVLERMPWPARPARRRP-r......
V4J588_9GAMM/89-219 ........vevmqstadea---------------------------KALRRHAETDLGA.hHSPDLFHGPETSAQVEQVAGACADVFQRRSSCVEGRNGQLALHHHGRDRLSDRKLAALTAVHHFHICRDDGTTAAERFFGRAHPVLFERLLLRVPLPPRPRRRRT-r......
A0A5C2HM94_9GAMM/414-559 ..................i-HDQLIPALYLQRVAQRMTTAEKAQPIAATSQALLEPLRQseHPIM-SLPEQERVQVEAVANECADLFQRSSSTVEGRNGHLALWHHPLHRLSDERLSALTIVHNYHNA-TGNDTPAKRLFQRQHDSLFAHLLNQVDLPRRPAQKR--vk.....
A0A2T1DDB5_9CYAN/183-298 ...................VKQSLLPAHYWHQQSVRTKTPTLKAAYQIAAQHAQAALMR..HPITTAMSCKQFTQWQTWATSMVTKFQRTSSPVEGRNGYLSQIHHNRRGLSTRRLRVMTTIHNFHLQRSDGSTAAE------------------------------.......
H8Z643_9GAMM/417-563 ...................MHEQLIPARYLERVATRQSRAEERDRLEALSERLLAPLRApdHPFQ-QLDAATQATLEQVAGDCADVFQRSSSAVEGRNGQLSLFHHGRHRLSERKLSALTAIHNFHIRRSDETTAAERLFGCAHPSLFEEVLKRTPLPPPARRRRA-r......
A0A080LYZ9_9PROT/43-156 .................lv--EPLIPALYLERVAARSTLAEPRHRLRTLSRQLLEPLRHgtHPLQ-ASPPTERAHLEQVAGDCADRFQRSSSGVEGRNGQLALHHQGRHRLSDRKLAALTAVHKYHIRRADD-----------------------------------pd.....
A0A5C2HG59_9GAMM/414-559 ..................i-HDQLIPALYLQRVAQRMTTAEKAQPIAATSQALLEPLRQseHPIM-SLPEQERAQIDAVANECADLFQRSSSAVEGRNGHLALWHHPLHRLSDERLSALTIVHNYHNA-AGNDTPAQRLFQRPHDSLFAYLLNQVDLPRRPAQKR--vk.....
A0A0N0V0B1_9DELT/1-137 ..................f--------LYWEKQADRTKATDLKECYQNAANEALDRLEK..HPSSQKFIT--KEDMVSWAEWMVSNFQRTSSAVEGRNGWLSQMHHNGRGLTAKRLKAQTVLHNYFLTRADGTTAAERLFGEKFSDPLEWVVEKMGDLPLPRKTKK-g......
A0A2K8U438_9GAMM/400-546 ...................LLTQLIPALYLERVANRSTLAEPRHRLHALSRQLLEPLRQrdHPLQ-ALPEAERARLEQVAGDCADLFQRSSSSVEGRNGQLSLHHHGRHRLSDRKLEALTAVHNFHLRRPDGTTAAERFFGRAHETLFAQVLQRMPLPPPPARRRP-r......
L8LTQ9_9CHRO/9-154 ...................VKHQLLATAYWYQQSQRADNSQLREKYEKAYHNARQTWLV..HPLTLNLTPESQNDWWNWALWMVSKFQRCSSPIEGRNGYLSQIHHNRRGLSSQRLKVATVIHNYVIRRSDGTTAAERLFCLKFPDLFEFLVHHLGELPQPRRARK-s......
A0A853IBU3_9GAMM/119-259 ..................i-RDHLIPIYYLAETAKKASKAALRKDLENKSQALRATLNE..EPSWQSLTDLEREQYH-----NARLFHRSSSCVEGRNEQLSLKQHNLKRMSNSKLKALTVVHNYFIKRADGTTAAERFFEEKPIDLFEYLIDHLDYPAMPAKRRR-a......
A0A8J7A9X8_9CYAN/1-100 ..................m----------------------------------------..-------TDNERQRWVLWCREFSAKYQRTSSAVEGRNGYLARLHHARRGFSEQSLNVLTIIHNFDLKRHDGTTAAQRLFGHDFPDVFEWMLAQVGDLPMPRRSSK-p......
A0A1X1QNR5_9GAMM/39-184 ...................LTSCLLPVVYWHHKMEQSKKPKAKKKCRKAWEQASIEIKV..HPFSESLSISEMERWLTWAENMVRQFHRSSSAVEGRNGCLSQMYHNGRGLSEKRLKALTVIHNYGIKREDGTTAATRLFDIEFPGLFSWLLDEMGELPLPRKGRE-r......
A0A1Z3HQR9_9CYAN/368-513 ..................l-TVGLLPLCYWQYQSQRTDKPTLKAQYRDAYQRAHNVLKA..HPLTRTLEAEVYRYWYSWASEMVTKFQRTTAAVEGRNGYLGQIHHSRRRLSDRQLQVMSVIHNFDLKRLDGSTAAQRLFKQPHPDLFQTVLAQMHDLPLPRQRAK-a......
K9W4Z7_9CYAN/378-523 ..................l-LGYFLPHFYWLSVIKQTKNPALKEIYTQVSRHYSSHLLE..HPLTSKVSKNEWIHWRSWAEQMSAQFQRSSSAIEGRNGYLSRIHHCGRGISSKHLQVLTVIHNFDIQRADKTTAAQRLFNQEFPALFDWVISQMGDLPLPRKSYQ-i......
V4JJC7_9GAMM/1-74 ...................----------------------------------------..--------------------------------MEGRNGQLALYHHGRHRLSDRKLAALTAVHHFHICRADGATAAERFFGRAHPALFERLLLRVPLPPRPRRRRT-r......
K9W250_9CYAN/157-302 ..................l-LGYFLPHFYWLSVIKQTKNPALKEIYTQVSRHYLRHLLE..HPLTSKFSKNEWIHWRSWAEQMSAQFQRSSSAIEGRNGYLSRLHHCGRGISSAQLRVLTVIHNFDIQRADKTTAAQRLFNQEFPALFDWVISQMGDLPLPRKSYQ-i......
A0A080LWY0_9PROT/147-292 ...................LTSKLLPVLYWHYQMRKTQNRVHRKRYQEAWQRALEAWKA..DPFHSGFSESELQRWLEWGEWMVRQFHRSSSAVEGRNGRLSQLYHNGRGLTKCRLAALTVIHNYGVRRSDGTIAAERLFSTSFPDLFDWLLNQMGELPLPRKSRH-r......
A0A6N1Y9G0_9GAMM/2-37 ...............vykr----------------------------------------..----------------------------------------------------KTIKGITVSYNYCIKRKDGTTAATRLFDIQFP----------------------.......
A0A850SUQ8_9DELT/1-104 ..................m----------------------------------------..---TAHVPSEEIKQWQSWAHWIATKFQRTSSAVEGRNGALSRMNHNQRSIPLTRLKVLTVIHNFGIKRQDGTTAAQRLFGQKFPDLFEWIVERVGELPCPREH---svt....
A7C2A3_9GAMM/1-124 ..................m-----------------------KKVYRRAWEEALSIYNA..HPITNKISDGESEQWLSWADWISEKFQRASSAIEGRNGYLSQIHHNGRGITPNRLKALTVIHNYDTKRRDGTTAAERLFDAKIPDLFDWLIEQMGDLPLPRKSRG-r......
A0A2K8U5E6_9GAMM/400-546 ...................LLTQLIPALYLERVANRSTLAEPRHRLHALSRQLLEPLRQrdHPLQ-ALPEAERARLEQVAGDCADLFQRSSSSVEGRNGQLSLHHHGRHRLSDRKLEALTAVHNFHLRRPDGTTAAERFFGRAHETLFAQVLQRMPLPPPPARRRP-r......
A0A1X1QV38_9GAMM/311-456 ...................LTTVLLPVVYWHHKVEQTKKPKVKEKYRKAWEQATDLFKE..HPLSATLSESEMQHWLTWADNMVRQFHRSSSAVEGRNGCLSQMYHNGRGLSEKRLKALTVIHNYEIKRENGTTAAMRLFGTNFPDLFSWLLNEMGELPLPRKER--gv.....
A0A850T4M3_9DELT/262-405 ...................MHNYLIPGNYLKLVANKERDVQRKAEILQVAQKLLLIV--..ESTGDACSDCNIEELNKAAIECAQLFQRSSSCVEGRNGQLALRHQGIHRLNDRQLKAYTIMHNYYIRRRDGTTAAERFFNAKPNDLFEYLLDHVDYPVRPRNSL--ks.....
A0A5C2HUS4_9GAMM/59-204 ..................i-HDQLIPALYLQRVAQRMTTAEKAQPIAATSQALLESLRQpeHPIM-SLPEQERAQIEAVANECADLFQRSSSAVEGRNGHLALWHHHLHRLSDERLSALTIVHNYHNA-AGNDTPAQRLFQRPHDSLFAYLLNQVDLPRRPAQKR--vk.....
F9UDR3_9GAMM/400-546 ...................VLEQLIPAIYLERVAARSTAAETRHRVQAVSTALLDALRRadHPLQ-RLAPANSARVEQVAGACADLFQRSSSCVEGRNGQLSLHHHGRHRLSDRRLAALTAVHNFHIRRPDSTTAAERFFGRTHPALFEQLILRVPLPPRPRRRRP-r......
A0A8J6XEW3_9CYAN/156-223 ..................l-ITCLLPLVYWQQQLTKTKSPTLRTQYQTAYSQAQQHYHR..HPSTKLASPAQIQHWTKWALV-------------------------------------------------------------------------------------dgesfst
A0A5C2HHN5_9GAMM/59-204 ..................i-HDQIIPALYLQRVAQRMTTAEKAQPIAATSHALLESLRQpeHPIM-SLPEQERAQIEAVANECADLFQRSSSAVEGRNGHLALWHHHLHRLSDERLSALTIVHNYHNAAAN-DTPAQRLFQRPHDSLFAYLLNQVNLPRRPAQKR--vk.....
#=GC seq_cons ....................ht.LlPhhYhpp.htptptst.+p.hpth.pth.t.ltt..HPhp.thstpphtph.phAtthsshFQRoSSsVEGRNG.Lu.haHst+tlSpp+LpsLTllHNacl+RsDGTTAApRhFsptassLFphlLpphs..PhPt+p+..t......
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