#=GF ID   DUF6414
#=GF AC   PF19952.3
#=GF DE   Family of unknown function (DUF6414)
#=GF AU   Paysan-Lafosse T;0000-0001-5663-0894
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF SE   MGnify-UniProt clustering
#=GF GA   25.00 25.00;
#=GF TC   31.50 48.20;
#=GF NC   21.90 20.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR045633;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family of proteins is functionally uncharacterised. This
#=GF CC   family of proteins is found in bacteria, mainly Firmicutes.
#=GF CC   Proteins in this family are typically between 231 and 275 amino
#=GF CC   acids in length. It has two conserved sequences motifs, GYY and
#=GF CC   RFN.
#=GF SQ   62
#=GS A0A563DUQ2_9MICO/1-130   AC A0A563DUQ2.1
#=GS D9R8I0_LACSW/14-247      AC D9R8I0.1
#=GS A0A437UU64_9ACTN/14-256  AC A0A437UU64.1
#=GS A0A3A9FSV1_9BACT/18-170  AC A0A3A9FSV1.1
#=GS A0A1B8RST3_9CLOT/25-277  AC A0A1B8RST3.1
#=GS R6PZL2_9FIRM/21-251      AC R6PZL2.1
#=GS A0A542XEI6_9MICO/25-255  AC A0A542XEI6.1
#=GS A0A7L5ZCT7_9ACTN/21-248  AC A0A7L5ZCT7.1
#=GS A0A4R2L8E3_9FIRM/24-261  AC A0A4R2L8E3.1
#=GS A0A8J7WUU9_9ACTN/14-243  AC A0A8J7WUU9.1
#=GS Q2FW43_STAA8/2-227       AC Q2FW43.1
#=GS A0A1E8Z1P7_9LACT/23-252  AC A0A1E8Z1P7.1
#=GS G6ER38_STRTR/66-322      AC G6ER38.1
#=GS R7L9J7_9CLOT/1-58        AC R7L9J7.1
#=GS A5N3W7_CLOK5/14-247      AC A5N3W7.1
#=GS A0A1U7M2V9_TISCR/16-269  AC A0A1U7M2V9.1
#=GS F9EH59_9ACTO/1-130       AC F9EH59.1
#=GS A0A0R1R140_9LACO/19-277  AC A0A0R1R140.1
#=GS F5X6Y5_STRPX/17-262      AC F5X6Y5.1
#=GS A0A3Q8WSS1_9ACTO/24-252  AC A0A3Q8WSS1.1
#=GS A0A0M5JD83_9BACI/14-273  AC A0A0M5JD83.1
#=GS S0IRN0_9FIRM/26-253      AC S0IRN0.1
#=GS A0A087CL75_9BIFI/28-257  AC A0A087CL75.1
#=GS A0A2S0WRM8_9ACTN/1-181   AC A0A2S0WRM8.1
#=GS A0A3A9BVK8_9BACT/14-129  AC A0A3A9BVK8.1
#=GS A0A0A3J1H3_9BACL/14-262  AC A0A0A3J1H3.1
#=GS B9E9N6_MACCJ/22-280      AC B9E9N6.1
#=GS A0A410PTV1_9FIRM/14-247  AC A0A410PTV1.1
#=GS R5IYC5_9FIRM/25-255      AC R5IYC5.1
#=GS A0A1Q8QSQ6_9FIRM/19-258  AC A0A1Q8QSQ6.1
#=GS A0A077HQS7_9CORY/24-256  AC A0A077HQS7.1
#=GS A0A0G3GZN4_9CORY/26-252  AC A0A0G3GZN4.1
#=GS A0A3A9F646_9BACT/19-249  AC A0A3A9F646.1
#=GS G2T0K7_ROSHA/26-279      AC G2T0K7.1
#=GS A0A1M6T8I5_9CLOT/14-135  AC A0A1M6T8I5.1
#=GS A0A2V2N555_9EURY/15-255  AC A0A2V2N555.1
#=GS A0A3A9BME1_9BACT/18-271  AC A0A3A9BME1.1
#=GS A0A0B5AVG4_9BACL/1-92    AC A0A0B5AVG4.1
#=GS A0A3A9DY65_9BACT/1-90    AC A0A3A9DY65.1
#=GS R7HGS9_9MOLU/18-250      AC R7HGS9.1
#=GS F0GXK4_9FIRM/23-276      AC F0GXK4.1
#=GS A0A5J6PUK0_9BACI/14-252  AC A0A5J6PUK0.1
#=GS R6P4C7_9CLOT/19-273      AC R6P4C7.1
#=GS A0A0L0QUR8_VIRPA/22-254  AC A0A0L0QUR8.1
#=GS H3NGA0_9LACT/1-233       AC H3NGA0.1
#=GS A0A1M4Z6N1_9LACT/23-252  AC A0A1M4Z6N1.1
#=GS G5ID28_9CLOT/18-264      AC G5ID28.1
#=GS A0A372SQH5_9FIRM/19-256  AC A0A372SQH5.1
#=GS A0A6S6XIA6_9FIRM/26-272  AC A0A6S6XIA6.1
#=GS A0A5K1JG61_9ACTN/1-231   AC A0A5K1JG61.1
#=GS W1UXJ5_9LACO/22-260      AC W1UXJ5.1
#=GS A0A264W139_9BACL/14-259  AC A0A264W139.1
#=GS A0A5B8TD36_LEULA/22-260  AC A0A5B8TD36.1
#=GS A0A7J5B7D8_9MICO/24-252  AC A0A7J5B7D8.1
#=GS A0A1T4NWV1_9ACTN/18-257  AC A0A1T4NWV1.1
#=GS A0A1G7A5R7_PEPNI/23-276  AC A0A1G7A5R7.1
#=GS R7L5E1_9CLOT/24-204      AC R7L5E1.1
#=GS A0A2K2TYW8_9CLOT/21-249  AC A0A2K2TYW8.1
#=GS A0A0R2ETK7_9LACO/13-260  AC A0A0R2ETK7.1
#=GS E7GU07_CLOSY/18-271      AC E7GU07.1
#=GS A0A0L6TWQ0_9FIRM/1-181   AC A0A0L6TWQ0.1
#=GS A0A7H8SF87_9BACI/14-243  AC A0A7H8SF87.1
A0A563DUQ2_9MICO/1-130              ........-------------.---------------------------.....------------------------------------------------.........-.----------------MAYAKMFTPYMVIAKTE-DQ...............G---.---.....-VDLARLDEALASAKGYYELLGSNKNGSK........R.VLRFNIKAFRNNYGLTDLGRM.RLVFHGVLVGQTLERSL...........GIEAEMS..........SEVKDKP.....VTATEL....VDGKP-----SENK......-DLLDVYDVVLAGVE..........
D9R8I0_LACSW/14-247                 ........DYLNIYDGGEKIQ.TKNKIEEKNK----ELASKTSANLFAK.....LSWLPFLGGSAETSASADFSLSGSSLVKTTLSNTVLTDFLNRAQNDER.........-.-ICVFNDYKVRAYKNSIAFFKMFTPFLKITKSDFTT...............DEG-.--F.....VFDISKLDEAFTSGKGYYELIAENTVGGMl......kKyIFRFNIVSFRNNYSIADLSKM.DLNYYAVKVGKSEEEML...........DISKEFN..........FEQKSI-.....SSAFDI....IEDQ------S--N......GNALDVFDVILAGV-d.........
A0A437UU64_9ACTN/14-256             ......na--LQRENRGAVQE.TSSQSSNMVL--NGNVSAESHFSTALG.....VPFIGRLKFLFNGKIELQYLREWDS--RTTVTSTDISMF----RAIES.........-.SLESFNKVQLHDVKNSLTSFRVATTFLKLAKPN-NQ...............D---.---.....-FNIREAADLLTSMEGY-DLYDI-GNERY........-.-VRFNQKAYLSNYKRNDISMS.VLDLYCMQVGDYPPDSF...........DYLKKLSamqslfdvptVQGKTLEdiyffSNSPEG....TVVEQKSCSENKQS......NRNIKLYDVLCAYV-s.........
A0A3A9FSV1_9BACT/18-170             ........DFMQIIVGGELKK.TTEFITEVNSGIEGAAGVEGSVGTEKNglskiFSFLSGATINAEAGVNANLSRKSDRIAKNILENTLLADFIALLDADKRrtk...nkrCsGIKIFPKVVVRPEVNSFSYIMLIAPFLSIIDGELPF...............KTSDgDAM.....KIDIT------------------------........-.---------------------.-----------------...........-------..........-------.....------....--------------......---------------nyk.......
A0A1B8RST3_9CLOT/25-277             ........DYIQIIEGGKLEK.TTELLGETSDSGNAGIDGKASVGIGKV.....LKALVGFEVNASVHAEMETSFNTNQMVKNIVKNTILTDFINLIEEIPSkkkn.sinsGgAIHKFKNYKIYAPKESMSYVALISPYLSMLNGGANI...............PAGE.FYI.....AID--KLDNTIKNAKGYYEFVGIREEEKV........-.IFRFNIKSFKNNYKAADLQKM.DISIYAIKVGKSSIEKL...........NFNNEFE..........VDEVYSI.....KDNPDY....EKKEKVEIDESIKD......--DLPVYDVLLAGVE..........
R6PZL2_9FIRM/21-251                 ........DYLDITNGGRLDW.STEENKKRVA----QILAEIEAQAKGG.....FNIISFLKGSISGNIDANSSGEVSKLLDTTIKNTLLTDYIAKAHKDEK.........-.-IEKFGNSGVYAPKNSVTLYKMYSSYLSVVPKD-QL...............P---.---.....-FDIEKLNEAVLGERGYYAMLLK--TESV.......pSsVLRFNINAFKNNYSLADLSKM.NLTYYGVKVGICKQAEL...........GIDQEFD..........FQGKSPK.....VTAESV....LGMNEE--VLNQEN......--DLVVYDIVLAGVK..........
A0A542XEI6_9MICO/25-255             ........DYLDISAGGKAVT.TAEDVRQRAN----NVHAEVEAKVAAK.....LSWLPFIGGSAGAGTGVEASRTGQSMLSKTLSNTILTDYLAKSADDHR.........-.-VRQLRGLRVTAPGDSMAYMKMFTPYMIIAKTE-DQ...............G---.---.....-IDLARLDEALAGAKGYYELLGEADDDVK........H.VLRFNIAAFRNNYGLTDLGRM.RLVFHAVHVGHTTERGL...........GMEAEMS..........TETE--T.....STLPTA....AE--LVDGAAAQPG......NDLLDVYDVVLAGVE..........
A0A7L5ZCT7_9ACTN/21-248             ........DLLDIVAGGKETT.ADEQTRERAA----DXSGESRGQGSRE.....FSWLPFLGGSVEAGAAASASAVGRSIFNKTLSNTILTDYLSKLENMSG.........-.-VDVLEGMTLTASKQSAAYMKMFTPYLAMLKVA-EL...............P---.---.....-VDFAALDSAMESAKGYYELIGTDPSNRK........L.ILRFNIRAFRNNYGLADLGRM.RLVFHGVQVGEATESSL...........TMWAEMQ..........EEQQTTP.....LTGLDI....LDAT-------DPD......PVNLVVYDVLLAGV-c.........
A0A4R2L8E3_9FIRM/24-261             ........DYVDVTNGGRLDW.TTEENKQKVA----KIVAEIEAQAKSG.....FNILNYIKATFQGKVDASAAVDLTSAFDKTIKNTLLTDYIQAAYEDSH.........-.-VKKFENSGVYAPENSVTLYKMVSSYMTIVPKE-EM...............P---.---.....-IDMEKLNEAILGERGYYEMLLKTEKDKK........S.VLRFNLKAFKNNYNLVDLSKM.KLTYYGIKVGTCSEDNL...........SIDKEFN..........FKPEEEK.....ITAEDI....VNDNESVSNEEESVs...ngKDELNVYDIVLAGV-v.........
A0A8J7WUU9_9ACTN/14-243             ........DYLDITAGGKAAT.TSEQVRERTK----DMHARVETSVAAK.....LSWLPFIGVSAEAGAGVDVASAGRSILSKTLSNTILTDYLTQVEGDDR.........-.-VKRLSGLRVTAPQGSMAFVKMYTPYMIIAKTE-EF...............G---.---.....-VDLARLDEALEGAKGYYELVGEQAANGS........KcVLRFNIKAFRNNYGLADLSRM.RLVFHGIVVGQTTESGL...........GMQAEMS..........HDTGPEP.....VTALDL....LDGPV-----APDK......-TLLDVYDVLLAGVE..........
Q2FW43_STAA8/2-227                  ........DLLQIEKKGNLTK.TVQLMHDEKGSASGESKVNMEFGKQSAvk.qiFDSLLGMSASASASAGINGNITGERVAKTILENTLIYDFLDTVEFRKK.........KtIIDISEGFKLNIQQDTMTYFATITPIASMFEGSKHL...............D--E.EEL.....SFDVSKMNEAIRSIKGYFELIGTRGNENR........-.VFRFNIESFKNNYRIQDLKFM.NLTLYSVLVGEISKENL...........NYDKEFD..........LNQGAKP.....------....--------------......---------------sgigkfkgis
A0A1E8Z1P7_9LACT/23-252             ........DFVTIKNGGKIDW.STNENKERLA----KLVAEIDAQAKTG.....FNLFSTFKATISGSVNTGYDSKMAKIMESTISNTLLTDYLSLAVEDKN.........-.-IHIFKSEEVYAPEESITIYKMYSSYLNVVPKE-EI...............P---.---.....-IDLTELNKAILGDRGYYQMLLG--SEPV.......pKtVLRFNINAFKNSYTLADLSKM.NLTYYGIKVGTCTMNQL...........SMENEFK..........FEKKKNE.....IDVTEI....VTGEK-----NEDK......NDLLDVYDVVLGGV-i.........
G6ER38_STRTR/66-322                 ........DLLQIEKKGNFSQ.TIELVNEVSGEANGGVKTSAAAGKQSAvk.tvFEKLIGLSGSIEGQVGVSGTVHGGRIAKTLLENTLLYDFLDTVEFRKR.........KsLIDITSGYKLTIDKESMTYFAMIAPITEMMEGNQRV...............D---.EEI.....TMTVSKMNQGIRNTKGYYELIGTKNKSEDnstdkgidKrIFRFNIDSFKNNYRIQDLRRM.NLNLYSIYVGETYMSDL...........NFEKEFD..........LNSDKTE.....LDFQGF....GNKNHDEKDIP---......DEIVPVYDVILAGVK..........
R7L9J7_9CLOT/1-58                   ........-------------.---------------------------.....------------------------------------------------.........-.------------------------------------...............----.---.....-----------------------------........-.--------------------M.DLCYYGIKVGTTKKEEL...........KLENEIN..........TAKKVLS.....EEDLSI....NIQ--------SS-......NNELPIYDIIIAGVK..........
A5N3W7_CLOK5/14-247                 ........DYLNIYDGGEKIQ.TKNKIEEKNK----ELASKTSANLFAK.....LSWLPFLGGSAETSASADFSLSGSSLVKTTLSNTVLTDFLNRAQNDER.........-.-ICVFNDYKVRAYKNSIAFFKMFTPFLKITKSDFTT...............DEG-.--F.....VFDISKLDEAFTSGKGYYELIAENTVGGMl......kKyIFRFNIVSFRNNYSIADLSKM.DLNYYAVKVGKSEEEML...........DISKEFN..........FEQKSI-.....SSAFDI....IEDQ------S--N......GNALDVFDVILAGV-d.........
A0A1U7M2V9_TISCR/16-269             ........DYMQIILGGEFKK.TTEFITSINSDMNASADVDGGIGTNGKnapklFSFLSGITFNASANGSVDVNRKKEKIARNILENTLLADFLDLIDKDQRkke..knrmCtSIKSFEKLIMYPEPNSFSFLMLAAPFFTMLDGDVPI...............PSNDeNEF.....KMDISKIEEAIARGRGYYEFVSHPNQIET........-.IFRFNSSAFRNNYTMSDLPKM.QLSLYAIYVGKTDKSKL...........DLSREFE..........FG-TRNK.....DRVSYI....EDTQ------SQDI......-IEVDVYDVVLAGI-a.........
F9EH59_9ACTO/1-130                  ........-------------.---------------------------.....------------------------------------------------.........-.----------------MAYTKMFTPYMVLLKLD-DA...............P---.---.....-FDLARMDEVLADAKGYYELLGETKDGSK........R.VLRFNLKAFRNNYGLTDLGRM.RLVFHGVLVGQTSEQAL...........SMEAEMS..........GSAGD--.....ATVTAV....ELVDGV--DMQSD-......-DLLDVYDVILAGVE..........
A0A0R1R140_9LACO/19-277             ........DLLQVRQKGHLTR.TEETIRSMTGKIGADADIKAQLDEDVGvn.klVSHISGLSAGINSMMGANGSLNGSKIARTVIENSLLYDFLESAESKRG.........TpLLDIKEDYALSIPKDSMTYFATIAPLTEMMEGHQQL...............D--N.PDI.....TMAISKMNSGIRNSKGYYEVVGEKTDSKFgks..ittQkVFRFNIDAFKNNYRIQDLPKM.NLVLYAIHVGTTKLSQL...........DFETEFN..........LDSQQSE.....VGFSGL....AKQAQSHQDADSND......EKSLDVFDVVLAGVR..........
F5X6Y5_STRPX/17-262                 ........DFLQIESKGKLTK.TTELMSTLEGGIDAQITGEVSLGKNGAlk.tiFEKMAGLSGGGSVSSTTSGAIQGNKIAKTILENSLLYDFLDTVELRKK.........NyLVDITENYTLEISENSMSYFAMIAPISEMMEGSQSI...............E-GM.ENV.....SMSFSKLNTGIREIKGYFELLGYNKEHKI........ErIFRFNINSFKNNYRIHDLTKM.TLKLYSIKVGETTINDL...........DFESQFN..........L--RRTH.....LSFSGI....SEDAMTYPD-----......-MKYPVYDVILAGVN..........
A0A3Q8WSS1_9ACTO/24-252             ........DLLDIVAGGKETS.SKESTKERAA----EVEAEARAKAAAK.....FNWLPFFGGSAEASAAASASAVGRSILNKTLSNTILTDYLSKLDDLKG.........-.-IERLDGLTVTARSDSAAYMKMYTPYLAMLKID-EL...............P---.---.....-VNLAELDSALTSAKGYYELLGQSVDGAK........R.ILRFNIQAFRNNYGLVDLGRM.RLVFHGICVGKAAESSL...........TMQAEM-..........-APGAEP.....APLTGL....DVVDGP----SAEP......STLLDVYDVILAGVE..........
A0A0M5JD83_9BACI/14-273             ........DYIDQYYEGRIEE.TESEIIKEEANTSASAQATVQIGLPKW.....MEILDLVAGKFKGRAEGKTDDSNQYLHQKMISGTILTTFKKITASIDS.........PsNLLELKDFKLNIPPESLTSLKTFTPFLRLFASQIQTiqvingesrsknsasDIGD.VDV....sTLDVSNLDNILENAKGYYEMIASNGKEKK........-.IVRFNLKGLRNNYQLIDFQRM.QLTLYGIPVGKCALEEL...........KDLQEFN.........vIQPEQQK.....IRLAGD....ALNS------ELKT......PNEVEIIDILLAGV-d.........
S0IRN0_9FIRM/26-253                 ........DYIDIVNGGRLDW.SKEENKERAA----KILTEIEAQAESG.....FNILNFIKASFSGGVCSNISGEISKMLDTTLKNTLLTDYISEAFKDNN.........-.-VRKFENDGVYAPENSVSMYKMYSSYLTIVPKE-QL...............P---.---.....-IDMEKLNEALLGERGYYAMLLASEKTPT........C.VLRFNIKAFKNNYNLADLSKM.ELTYYGVKVGICKKEQL...........SIEKEFE..........LKSENAK.....SKPEDI....LDGTT-------PE......NDFLEAYDIVLAGV-v.........
A0A087CL75_9BIFI/28-257             ........DYLDISAGGKLET.STEGQKDKTS----ELQAHAGAKIAAR.....LSWIPLFGVQADASAEAEISRNTSSLLRQTLSNTVLTDYLPRAYQDSN.........-.-IEKMRDYSVSIPLNTFTYAKVFTPYMQIANTK-DT...............G---.---.....-IDLAKLDAALLSAKGYYELLAMKIQSQE........KaILRFNIRAFRNSYGLADLTKM.NLVYYAVKVGKAKEDEL...........DITHELP..........----HDS.....ETTPVD....LINDKSDT--ASKA......GDSLSVYDVILAGVE..........
A0A2S0WRM8_9ACTN/1-181              .......m-------------.---------------------------.....-------------------SRVGQSILSKTLSNTILTDYLEEVAGDEC.........-.-VRPLRDYKVTAPADSMAFMKMYTPYMVIARTE-DT...............G---.---.....-FDLARMDEALERAKGYYELLAESSVDPS.......eKcVLRFNIGAFRNNYGLTDLGRM.RLVYHAILVGSSTEAGL...........SVDAEMG..........DAPQHTS.....KSPTAL....DVVDGPVA--GSDS......EVLLDVYDVVLAGVE..........
A0A3A9BVK8_9BACT/14-129             ........DYLTILNGGTLLI.SDLEEEKVGN----NTEIKVGAKLKVL.....FNSL-FVSGSANLDSNIGAYTSGENFIKTTISNTTLSDFIEVVKESDS.........-.DIKCMNGYSIYIMPNSIAYFQTITPYLAMTEG----...............----.---.....-----------------------------........-.---------------------.-----------------...........-------..........-------.....------....--------------......---------------g.........
A0A0A3J1H3_9BACL/14-262             ........DTLDQSNNGRLQE.ITKEMVDKANELSGNIELEGKASTGIF.....----SIFKVGFGMDTKGQFSRKGSNILTTTITNTILTNFLKLLEEKKKn.......nDyTFEELQNYKLSIVPETFTFLKTLTPFIKVYSNSADSkvvn......pdqsnNS--.--SslsenNLDYSLFDDVIANAKGYYELLATKDKEQK........-.IVRFNLDGLRNNYKLTDLQKM.NLIIYGIKVGQCTLESL...........NYKYEIG..........-------.....TEKPTV....VNTGFDALRGNESK......-DELEIIDVILAGIK..........
B9E9N6_MACCJ/22-280                 ........DMLDQNNEGRLQY.LEKTSKAKGASLFSGIFSNISNN----.....--------SQADAFIKTYGSMKFDKQIEKQITNTIKNDFIMKIESQIT........gDfNLEHIKDYSLYILNGTSTYYKTISPITKIIKDFTKL...............DGGKdFD-.....NIEFNKFEELIDDMKSYHELIAYKTNSAK........-.IIRVNPRHLQNNYKISDLRKM.KIDIVGVKIGQSSINDImfeslintddnNLQDEINk.......stFEERIDEf...gKDSFTP....TLNNSEKTNSQAKEin.fdySKPIDIIDVIIAGVK..........
A0A410PTV1_9FIRM/14-247             ........DYLNIYDGGEKIQ.TKNKIEEKNK----ELASKTSANLFAK.....LSWLPFLGGSAETSASADFSLSGSSLVKTTLSNTVLTDFLNRAQNDER.........-.-ICVFNDYKVRAYKNSIAFFKMFTPFLKITKSDFTT...............DEG-.--F.....VFDISKLDEAFTSGKGYYELIAENTVGGMl......kKhIFRFNIVSFRNNYSIADLSKM.DLNYYAVKVGKSEEEML...........DISKEFN..........FEQKSI-.....SSAFDI....IEDQ------S--N......GNALDVFDVILAGV-d.........
R5IYC5_9FIRM/25-255                 ........DYVTIMNDGNIT-.IEEINKAIEG-KDNEIEVNGEASIKKS.....--FLKMLNFSVGVKSDVAAHSSNEKIVNSTITTNIMTEFIKLADKDDN.........-.-IEKLVDLKLDIDQDTATYLKSMFPYLSLLKNPDKF...............EELK.---.....DINTNKIDEVILSTKGYFEFLAYKSGVIF........A.ILRFNIDCFKNNYKFNDLIKM.NLCYYGIKVGTTTKESI...........KLENEIN..........QYSRVL-.....------....TEEEFDSSINRPD-......-NELPIYDIIIAGVR..........
A0A1Q8QSQ6_9FIRM/19-258             ....rnil---QEQNKGSKTT.QTDFVSSTGV----AIEVGVEAKVNLS.....VPFWDRLSFLFSGKINASFMIKRDS--STTITSTE----ISEFEELKT.........-.HLTEIKDTLIYDIENSSTFFRVAGGYLRIVKGG--V...............E---.---.....GVDTSEFKAVMDGYDGYDTY-K--VDSHR........-.YVRFNNSAFVSNYKRNDLLAT.KMTLYCISVGEFDKEKF...........DFMKQLFkmet..llsgVNQHKSLaeaypTRQSNA....EDTARSVMTSDDNR......PPKIQLYDVVYACV-t.........
A0A077HQS7_9CORY/24-256             ........DYLDIIAGGTLST.TKEDIRDRTT----EAHAAVDAKLSAK.....LSWLPFLRGSADLGAGAEASIAGESILSKTLANTILTDYLKSAGEDAK.........-.-ISKLEGYSVFAAQESMAFMKIYTPFMIAARTE-DA...............D---.---.....-FDIARMDEALEKAKGYYELLGESVNGRK........V.VLRFNIRAFRNNYGLSDLTRM.NLVFHGIEVGRTTEASL...........NIKSEM-..........-AQGATG.....APKLED....LIQDSVHADPGSKE......DVNLPVFDVVLAAVE..........
A0A0G3GZN4_9CORY/26-252             ........DLVDLDAGGREKV.TDTEAERLAK----EAEGKISASFAAK.....YGWFSFLGAKAEVSGSASGSKTGSKIIEKSLSNTILTDYLDKISTKKK.........-.FIESIGHVKLTPVEGSMAHVKMFTPFMVIANTA-ET...............G---.---.....-IDLAKLDEALTQAKGYYELIASDDSGGK........R.VLRFNLKAFRNNYGLNDLCRM.DLMFDCIKVGHATLESL...........SDEFGV-..........-Q--ATS.....EFSANL....ILEHG-----EKEK......IDELEVYDVILAGV-i.........
A0A3A9F646_9BACT/19-249             ........DYVDVTNGGRLDW.STQENKEKIA----KIVAEIEAQAKSG.....FNILNYIKATFQGKVDASASAELTSAFDKTIKNTLLTDYIQAASEDEH.........-.-VKKFENSGVYAPENSVTLYKMISSYLTIVPKE-EM...............P---.---.....-IDMEKLNEAILGERGYYDMLLKTEKERK........N.LLRFNLKAFKNNYNLVDLSKM.KLTYFGIKVGTCGENHL...........SIDKEFE..........FQPVEEK.....TTAEEI....VEGEKSA----DER......EKELDVYDIVLAGV-v.........
G2T0K7_ROSHA/26-279                 ........DYVQIIAGGALEK.TTQLLKETDKNINTDASVSGKAGISGV.....FKALLGLEAQASADASMGISLNTNKMAKNIVKNTILTDFLGILNDEKQnrk..gkisQgSIKKFEGYTISVEKDSLSYIVMVSPYLSMLKGGASV...............PAGE.FDI.....AIE--KLDNALKSAKGYYEFVGTKGKSKV........-.VLRFNINSLKNNYKINDLLKM.NLSIYAIKVGTTTLSQL...........DVNKELD..........IDFYSRP.....KDNPDY....TSSEKKTSDDDTDK......NRKLDVYDVLLAGVE..........
A0A1M6T8I5_9CLOT/14-135             ........DYIEITKGGKYEE.FEEKIKDRMRKAMADIEAE----ASAK.....FSLFPFLKMGAGTQMNGEVSNHSNKIITNTLSNTVLTDYLKISKKDRK.........-.-IKKFKKCNIYAYKESMTFFKMYTPWIGYTKLD---...............----.---.....-----------------------------........-.---------------------.-----------------...........-------..........-------.....------....--------------......---------------sknsdm....
A0A2V2N555_9EURY/15-255             ........DYLYIKHGGQINH.LKEKKEETDEKTVLDAQGQMGFGTGIL.....SNLMPFLKANLEVKGGVEYNKIGESIIRTFVTNTILSDFTNEPDLENS.........-.-FIKLEGYKLKAYPNSFSYIKMYSPYFSMFKIE-TL...............N---.-DM.....PIIFQKIDEALEKGRGYYELIAEDSEGTK........-.ILKFNLKAFRNNYSLVDLTKM.DLTYFAVKVGKMNVHDL...........DPKNEFN..........VTPNFGS.....NDIADI....IHEEDNIGLDSTSD......NNLLDVYDVILAGIQ..........
A0A3A9BME1_9BACT/18-271             ........DYVQIIAGGELEK.TTQLLKESEKSGEADTSAGGKAGISGI.....FKALLGLEAQASAEATMGITLNTNKMAKNIVKNTILTDFLGIIDGKATdkg..grlkQgSIKKFQGYTISVEKDSLSYIVMVSPYLSMFKGDLGI...............PAGE.FDI.....AVE--KLDNALRSAKGYYEFIGTKGKSKV........-.VLRFNINSLKNNYKINDLLKM.NLSIYAIKVGTTTLEQL...........NVNKELD..........IDFYNTA.....KDNPDY....HAGEQEAPNPENSK......SKRLDVYDVLLAGVE..........
A0A0B5AVG4_9BACL/1-92               ......mi-------------.---------------------------.....------------------------------------------------.........-.------------------------------------...............----.---.....---------------------VNEKNTKS........-.VLRFNISAFKNNYSLADLAKM.NLSYFGVQVGTCSEEQL...........SMEKEFE..........MEESIKK.....PKASEI....VMGDNA-----APV......RNVLNVYDIVLAGV-m.........
A0A3A9DY65_9BACT/1-90               ..matidg-------------.---------------------------.....------------------------------------------------.........-.------------------------------------...............----.---.....--------------------------NEV........-.ILRFNRSAFRNSYTMSDLPKM.QLTYYAIHVGQIEKSAL...........QVQKEFE..........FGTTKTS.....KRIDYA....SISED------CSV......ATEIDVYDVVLVGV-l.........
R7HGS9_9MOLU/18-250                 ........DYITISDGGKAISeIINTEQETD---TSKLESETSTGFKIP.....--FFTWFNLQAKIGIDSNINNINDGVVKSTLTNTILTDYIKKADTDEK.........-.-IKKISNYQITPIKDSVSYYKMYTPYMLLIKKE--L...............N-DK.ISA.....EVDITKIDEVLKETKGYYEFLATNGKEQV........-.IIRFNISSFKNNYKINNILGM.NLLLYGVNVGSAEKDDF...........SIEKEFE..........Q-NESKE.....ITADEI....LEVTS-----KAPE......HKKLKIYDIVLAGV-a.........
F0GXK4_9FIRM/23-276                 ........DYLQLMSGGKLEK.TTELLENASKDAKAGADAATKIGFGGL.....IKALLGWNAEVGVTASAGLSFNSEKMVKNIIKNTILTDFVNVLEENENktav.sklpKgTIKKFSGYKITAEKDSLSYFVMISPYMNMFQSGSTI...............PGGE.LS-.....-ISLEKLDSVLRNAKGYYEFVGTRGNSNV........-.ILRFNISAFKNNYMISDLLKM.NLSIFAIKVGETTLDML...........NINKELN..........LDLKNSV.....VDNPSY....EESNKDNG-QNTDS......SKKLPVFDVLLAGVE..........
A0A5J6PUK0_9BACI/14-252             ........DILQIEYGGELIS.VDEEKGTVHFGGKAEVSAEV----GAG.....TNFFTAIKAAFSVKVSADAASASDSLVTKTISNTILADFYGLSSKLKE.........EeKLHIFKGFSIRPIKNSFAFIKMYTPYMKIIKEDSPL...............M-SE.-MQ.....DFDIHKLDEILENAKGYYELLAYKDDTQV........-.ILRFNINTFKNAYSLMDLPKM.KLQYYAVEVGEAKETDL...........IIENEMD..........GNGETTR.....LSASEV....LGDDV----GTNAV......SDYLKVYDVILAGVE..........
R6P4C7_9CLOT/19-273                 ........DFMQIIAGGELKK.TTEFITEVNSGIEGTAGIEGGVGTEKNalskiFTFLSGATINAEASVNTNLSRKSDRIAKNILENTLLADFIALLDADQRrpk...nkrCgGIKVFPKVIVRPEVNSFSYIMLIAPFLSMIDGELPF...............KTSDgDAM.....KIDITKIEEAIEKGRGYYEFVATVDGKDV........-.ILRFNRSAFRNSYTMSDLPKM.RLTYYAIHVGQIEKSDL...........QVQKEFE..........FGTTKAS.....KRVDYA....SASEG------GSV......ATEIDVYDVVLAGV-l.........
A0A0L0QUR8_VIRPA/22-254             ........DLLELEKEGMESV.VIKKLNETAA----QVEAGASVNKGIF.....----NFARL----KLSGNASHQKNNIIETQITSTLISSFMDIIKTNQK.........-.-ITKLENHQLIIPKDSSAYFRNLVPILHMIDDINKLntl.........saeD--K.DNF....sGINLKGIEDTLDSLSGYYDLLCICENGKK........K.IVRFNIAGLRNNYNLNDLTKM.NLTLFGVKVGESLDTNL...........EFEHQID..........--NMTTP.....HNTTKT....GLDF----DEEQTI......QVTYEIIDVILAGV-..........
H3NGA0_9LACT/1-233                  ..mnegek-------------.VYKSESTSTSKFKGELNIGGELKTKFN.....VPFLSRLKFLFTGKIDVSYLRQKDSL--TSITSTEISEF----EKLKS.........-.RLTKMKSIQINDVQNSSTVLRMAGGYLRIIKGG--I...............D---.---.....DLDTREFKNVMDNYDGYDTY-RIDDKR--........-.YVRFNNTAFVSNYKRNDLLTT.NMTLYCIPVGEFEKERF...........DFLKYINeme....nlfSTKTQTG.....DTLAEIypphIQYESKATINEFKQ......EDTVKLFDVVYASI-d.........
A0A1M4Z6N1_9LACT/23-252             ........DFVTIKNGGKIDW.STNENKERLA----KLVAEIDAQAKTG.....FNLFSTFKATISGSVNTGYDSKMAKIMESTISNTLLTDYLSLAVKDKN.........-.-IHIFKSEEVYAPEESITIYKMYSSYLNVVPKE-EI...............P---.---.....-IDLTELNKAILGDRGYYQMLLG--SEPV.......pKtVLRFNINAFKNSYTLADLSKM.NLTYYGIKVGTCTMNQL...........SMENEFK..........FEKKKSE.....IDVTEI....VTGEK-----SEDK......NDLLDVYDVVLGGV-i.........
G5ID28_9CLOT/18-264                 ........DYIQIIEGGKLTK.TTELLSEDTDNGGANIAAEASVGINGL.....FRSLIGFGAKVQTESKLETSFKSESLVKTILQNTILTDFLDIVEDEKA.........-.QVKVFNDIKIKVIKDSLSYIIMISPYMKMFKGE-GL...............NVNTdLDL.....SIDILKMDESIKLAKGYFEFEGVKDNTSV........-.ILRFNIDSFKNNYKISDLLKM.DLTIYAVPVGKVDRKNI...........SIVSEINa.......atVDDEASN.....YDNPRY....GDTDTREGNNSGD-......--ILTVFDVLLAGV-s.........
A0A372SQH5_9FIRM/19-256             .......n-ILQERDHGELSK.VTDISSTAQA--QASFATEASAKLKLE.....VPLVSRISFLFTGKIDASYVIKRDS--TTTISSTEISEF----EKLKP.........-.LLVSIPNVQLSDIENSSTSLRVAGGYLKIVKGG--I...............E---.---.....GLDTKEFKTVMDSYDGYDTY-K--VDEKH........-.YVRFNNSAFVSNYKRNDLLTT.TMTLYCIPVGSFDKMRF...........DFIQEISkmer..listAEQPQTLa...dLYPPEI....EIKSKTDTANSQKE......IENVTLYDVLYACV-t.........
A0A6S6XIA6_9FIRM/26-272             ........DYVQIVTGGKLEK.TAELLDQTKD--NGEAGAKASVGFGGI.....LKALLGFSVSASANASIDTTFNTERMAKNIVKNTILTDFIDILSRNEQssks.ikkaQgAIHKFEGYTISAPKDSLSYVALISPYLSMLQGG-GI...............PAGN.FNI.....AIE--KLDNTIKSAKGYYEFIGSKNKQSV........-.IFRFNIKSFKNNYKVTDLLKM.DISIYAIKVGTSSISNL...........NLNKEFA..........ID--TVT.....KDNPSY....RKENTN---TSNRI......EKQLNVYDVMLAGVE..........
A0A5K1JG61_9ACTN/1-231              mseiattd-------------.------DKSAEGGAEIKGSIGVRAW--.....--FANLVKGSVSAEGSLSASFKDDTVVKSIVTNTVLTDFLAAVDGEES.........DkRIEKFDNCKIVQIPGSISSLSLLTPYLSMLRSGQGI...............EAGE.FNI.....SLD--KLDSTLTKAKGYFEFFGNNDDGSR........I.VLRFNGLGFKNNYKQGNLLNM.NLRLYAVNVGKTRIAEL...........AADKELS..........FE-GFSS.....VTNPDY....VEGAENEEST-VGE......DESLDMYDVILAGV-v.........
W1UXJ5_9LACO/22-260                 ........DALQIVDKGSALE.SLSKTLEKES----SIDAEGNVGKSF-.....---LGMIGF----GLKGNAKRDKHTIMQSQVTSTLISQFLEKVSAGKI.........-.VLCTVNKPTLRIQKDSIAYFRNLLPITHMIKDFSAL...............ENVD.EDSqrvlsALNFDQLGDSLDSFSAYYELEGIFMERPA........-.IFRFNIDGLRNNYSLLDLAKVdKLKIYGLTVGYRDSINL...........AFDNQIDk........lVAEVDDE.....LDFDDL....RDNESE----KDEN......IELYPVIDVILAGVE..........
A0A264W139_9BACL/14-259             ........DILDIKSNGRTEQ.IMETMVEKAS----KFSLDGKIGTG--.....--ILDFFNFGISANSSGQYDGGKSNILKTNLTNTILTNFIDLLKKEES........sEyGLEELKDSKLSIPPDSAAFIKSIAPFIKFFKSSEEF...............KNTS.DPIl...dNIDLHSVDDVLLNAKGYYELLAINQKGDK........K.VVRFNLEGFRNNYKLNDLEKM.NLTLYGVKVGTCLEENL...........SFEKELSf.......gnQQSKKKQ.....SQNFGY....NPHEKNNKQNKPE-......-NELDIIDIVLAGI-t.........
A0A5B8TD36_LEULA/22-260             ........DALQIVDKGSALE.SLSKTLEKES----SIDAEGNVGKSF-.....---LGMIGF----GLKGNAKRDKHTIMQSQVTSTLISQFLEKVSAGKI.........-.VLCTVNKPTLRIQKDSIAYFRNLLPITHMIKDFSAL...............ENVD.EDSqrvlsALNFDQLGDSLDSFSAYYELEGIFMERPA........-.IFRFNIDGLRNNYSLLDLAKVdKLKIYGLTVGYRDSINL...........AFDNQIDk........lVAEVDDE.....LDFDDL....RDNESE----KDEN......IELYPVIDVILAGVE..........
A0A7J5B7D8_9MICO/24-252             ........DLLDIVAGGKETS.SKESTKERAA----EVEAEARAKAAAK.....FNWLPFFGGSAEASAAASASAVGRSILNKTLSNTILTDYLSKLADLKG.........-.-IERLDDLTVTARSDSAAYIKMYTPYLAMLKID-EL...............P---.---.....-VNLAELDSALMSAKGYYELLGQSTDGAK........R.ILRFNIQAFRNNYGLVDLGRM.RLVFHGIRVGKAAESSL...........TMQAEM-..........-APGAEP.....APLTGL....DVVDGP----SAES......STLLDVYDVILAGVE..........
A0A1T4NWV1_9ACTN/18-257             ......na--LQRENRGAVQK.INSQSTSTVL--DGDINAESRFSTSLG.....VPFVGRLKFLFSGKIELQYLREWDS--RTTVTSTDISMF----RTIES.........-.SLTQFDKVQLHDVKNSLTSFRVAATFLKLVKSN-DQ...............N---.---.....-FNTSEAEDLLCSMEGY-DLYDIGDNRY-........-.-VRFNQKAYLSNYKRNDISMS.VLDLYCIRIGDYPLDSF...........DYLKKLNsmqslfdvptI----QG.....KTLEDI....YFSNSSSEAEQQPNigsrqnDRLIKLYDVLCAYV-s.........
A0A1G7A5R7_PEPNI/23-276             ........DYLQLMSGGKLEK.TTELLETASKDAEVDTDAATKIGFGGL.....IKALLGWNAEVGVTASAGLSFNSEKMVKNIIKNTILTDFVNALEENENktav.sklpKgTIKKFSGYKITAEKDSLSYFVMVSPYMNMFQSGSTI...............PSGE.LS-.....-ISLEKLDSVLRNAKGYYEFVGTKGNSKV........-.ILRFNISAFKNNYMISDLLKM.NLSIFAIKVGDTTLDML...........NINEELN..........LDLTNSV.....VDNPSY....EESNRDNG-QNTNS......SKKLPVFDVLLAGVE..........
R7L5E1_9CLOT/24-204                 ........DYVTIMNEGNITV.-EEINKAISG-NNAEVGIEGSAS--VK.....TSLLKMLNLSLGVKAGASGHQSNEKIVNSTITTNIMTEFIKLADLDSN.........-.-IKKLTGLRLRIDEDTLTYLKSVFPYLSLLKDPEKI...............DEL-.K--.....EINIEKVDEVILSTKGYFEFLAYKDNVEE........S.VLRFNVDCFRNNYKFGDXXXI.-----------------...........-------..........-------.....------....--------------......---------------tinlgiy...
A0A2K2TYW8_9CLOT/21-249             ........DYLDITNGGRLDW.SKAENKQRAA----EILTEIEAQAKGG.....FNILSFLKGSVSGSVDAKASGEISKLFDSTIKNTILTDYIEEAYKDVR.........-.-VEKFKKSGVYAPANSITLYKMCSSYLTIVPKD-QS...............P---.---.....-IDMEKLNNAVLGERGYYGMLLKTENVPA........S.VLRFNINAFKNSYNLADLSKM.ELTYYGIKVGTCSTNEL...........SIEKEFE..........FQNTSEE.....VTAEKI....LNGSTT----QQS-......-ERLTVYDIVMAGVE..........
A0A0R2ETK7_9LACO/13-260             ........DYLTISNHGQRST.SSQTEKTVEGSTSADVKVKSKLGKWLS.....----VIPGIEIDGEVNLSGKVAADKLVKSSVTSAVLSDFLESAAKPSD.........-.EIVKLEDYSLSLYKGSIEYIQSISPYLMMTNGKLDI...............DGG-.--V.....QIEANKIYDALKLGKGYYELVGRKPNELK.......ySaIFRFNNAAFQHNYGISDLTSM.RLVSYGVKSGNKLLSTL...........NFSKSFQe.......ptATEPVTSl...tHNLETD....SKIEKKIDRLSDMV......EAGLPMFDIILTGI-v.........
E7GU07_CLOSY/18-271                 ........DYVQIVAGGELEN.TAELLNSREGNEKQDVHATAKGGIGGV.....FKALLGWEVGASADMAAGLSFNSSKMMKNIVKNTILTDFLTILEDKGTltksaskmpKgAIKKFKDYTISAEEDSLSYMVMVSPYLSMLKTGSAI...............PAGE.FNI.....AVD--KLDNALRHAKGYYEFVGVKGRSRV........-.ILRFNINSFRNGYTISDLLKM.NLSVYAIKVGRTTLDML...........NVNKELG..........MNVSIIP.....KDNPSY....EEQSDD--TENTSN......SQVLDVFDVLLAGVE..........
A0A0L6TWQ0_9FIRM/1-181              .......m-------------.---------------------------.....-----------------SAAANTDKLAKTILQNTVLSDFLEACKEIEN.........-.SIDKFESYHLTEPAGSLTEMLKFSVYTHMMNGSTRI...............S-TN.ENI.....ELSIEKFDETIKLAKGYFEYIGIKDDRKA........-.VFRFNLDALKNNYRSSDLTTM.NLSIYTIRVGIITDKEL...........DFKNNSN..........---TNNQ.....KRFFDE....KSEDT------SRT......YFEYELYDVLLAGVE..........
A0A7H8SF87_9BACI/14-243             ........DYLDIKHGGNSQT.TGEEVDEKAK----KALARLETQAGAG.....LKFLHVLKGAFSAEANGEITKQGTKVLKNTFTTTVLTDFVSETKDGRS.........E.DITVFRDYRLMAKKDSFAFAKMYTPYTVLLKDD--I...............D---.---.....HINISKLDEALEHAKGYYELIGIKNNNKV........-.VLRFNIDAFRNNYGLTDLIKM.DLNYYAIQVGECLEDDL...........LMEKEMS..........-EETKEP.....NKLSAM....DIFEG-----KCPE......NPYLKVYDVILAGV-g.........
#=GC seq_cons                       ........DhlpIhssGphpp.opp..pppss....phtscspsththh.....hphlshhpsphpspsssshshpspplhcsplpNTlLoDFlphhpppcp............lcphpshplps.psShoah+hhoPahphhcsp.ph...............s.............l-hp+l-pslpssKGYYEhlu.psppph..........llRFNlpuF+NNYplsDLt+M.pLshYulpVGpss.ppL...........shppEhs..........hp.tpp......hshssh....htspt.....ptpt.......p.LsVYDVlLAGV...........
//