#=GF ID DUF6424
#=GF AC PF19988.3
#=GF DE Family of unknown function (DUF6424)
#=GF AU Williams LS;0000-0001-5551-8526
#=GF AU Finn RD;0000-0001-8626-2148
#=GF AU Fragoso S;0000-0001-7018-3891
#=GF SE Manual
#=GF GA 25.00 25.00;
#=GF TC 31.20 30.60;
#=GF NC 24.70 22.60;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Family
#=GF WK Domain_of_unknown_function
#=GF RN [1]
#=GF RM 21640802
#=GF RT Molecular cloning and identification of the laspartomycin
#=GF RT biosynthetic gene cluster from Streptomyces viridochromogenes.
#=GF RA Wang Y, Chen Y, Shen Q, Yin X;
#=GF RL Gene. 2011;483:11-21.
#=GF DR INTERPRO; IPR046309;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This entry represents a member of a biosynthetic gene cluster
#=GF CC (BGC). This BGC (BGC0000379) is described by MIBiG as an example
#=GF CC of the following biosynthetic class, NRP (non-ribosomal
#=GF CC peptide), in particular the glycinocin A biosynthetic gene
#=GF CC cluster from streptomyces viridochromogenes [1].
#=GF SQ 23
#=GS A0A7W9PST1_9ACTN/2-284 AC A0A7W9PST1.1
#=GS A0A2A9F9D5_9PSEU/4-260 AC A0A2A9F9D5.1
#=GS A0A101NKU5_9ACTN/2-236 AC A0A101NKU5.1
#=GS A0A1B1M8T1_STRLN/1-289 AC A0A1B1M8T1.1
#=GS H2K669_STRHJ/2-284 AC H2K669.1
#=GS A0A0X3UWB9_9ACTN/1-295 AC A0A0X3UWB9.1
#=GS A0A0A8EHJ9_9ACTN/2-278 AC A0A0A8EHJ9.1
#=GS A0A6P2C112_9ACTN/2-179 AC A0A6P2C112.1
#=GS A0A6P2C112_9ACTN/178-281 AC A0A6P2C112.1
#=GS A0A0M8WZY7_9ACTN/2-284 AC A0A0M8WZY7.1
#=GS S5UVA5_STRC3/2-281 AC S5UVA5.1
#=GS A0A6I6S896_9ACTN/3-271 AC A0A6I6S896.1
#=GS A0A3G9IF09_9ACTN/11-232 AC A0A3G9IF09.1
#=GS A0A1H4S5P5_9ACTN/1-282 AC A0A1H4S5P5.1
#=GS A0A1H0NHM0_9ACTN/4-281 AC A0A1H0NHM0.1
#=GS A0A1B1B107_9ACTN/1-279 AC A0A1B1B107.1
#=GS A0A553ZRK3_9ACTN/2-266 AC A0A553ZRK3.1
#=GS A0A3N4ZM04_9ACTN/2-279 AC A0A3N4ZM04.1
#=GS A0A3Q9G3B0_STRLT/3-215 AC A0A3Q9G3B0.1
#=GS A0A7W7LNW8_9ACTN/1-255 AC A0A7W7LNW8.1
#=GS A0A1Q5G5G9_9ACTN/2-284 AC A0A1Q5G5G9.1
#=GS A0A117PK76_9ACTN/1-279 AC A0A117PK76.1
#=GS A0A0M9YQT8_9ACTN/1-286 AC A0A0M9YQT8.1
A0A7W9PST1_9ACTN/2-284 ...........................................tragtvatar-------------------MPDTVKPGGIESEN.HPWRIRLVEHPKRFESPFFKAAKRTARKILDSL--DDADLPYGPRPtg.......sehWEMHHGGSLWVMTR---SGWRMYRARVGIEWSMQFCADPARVDRLRQDAAELVAGFPETL.DALADLGYEEAGELLRTPIEDADGVEAWTDSLFNACVPMSRGNHQGILPK.........VPGEHHYPWPVKGADF.VRYDDFQLWVTLPDGTHGAVTPVDRRGSGDGHVRLVLA.......P.......E.......GS.QAAGTLAKAQEHG.LM......AVLPPNSSAALQAFAGQIEPGQRTASGPL-p..........................................................
A0A2A9F9D5_9PSEU/4-260 .............................................skaagtht----------------------------TPKET.HPWSVFVADHPQRADSRWFTAAKRTAKKILATF--PDDELPYGPAP............WEMHHGGSLWVRGD---DGWRMFLARAGIEWSMQFCADPVKVDRLRQDAATLVRAFPGTL.PALEKLGYADAPDILSTPIKTAGDVARYTDSLFNSCVPLSRADHQGILPT.........AAGEHHYPLPVKAGDF.IRYDDFPLWVTLNDGTHVAVTPVSPRGQGDGRVRMVFA.......R.......H.......GT.QAGDAVALAQEEH.KA......VILPDDHPVAREAFKQQTP-----------h..........................................................
A0A101NKU5_9ACTN/2-236 .................................................lrkm---------------------------------.-----------------------------------NDADLPYGPRPvdpgq..ggaehWEMHHGGSLWVMGS---HGWLMYRARVGIEWSMQFCADPAKVDRLRQEAAELVDAFPRTL.PALAELGYDRAEELLRTPIKDADGVEAWTDSLFNACVPLSRGNHQGILPK.........VPGEHHYPWPVKGADF.VRYDDFQLWVTLPDGTHGAVTPVDRRGSGDGHVRLAFA.......P.......E.......GS.DASATIAEAQDRG.LM......AVLPANSPVALQAFSRQITPGRHTASGPL-s..........................................................
A0A1B1M8T1_STRLN/1-289 .....................................................MPDADSVADRGASGAGGAGGQVVLEPGGTHGGN.HPWKIRLVKHRERSESSHFRAAKKVAKKILLEAGAGAGDLPYGAGP............WEMHHGGSLWVRTS---TGWRMYRARVGIEWSMQFCADPVKVDRLRREAADLVAAFPMTL.AALDALGYQRARTLLSTPVTDADTVEAWTDSLFNACVPLSRPHHSGVLPK.........AAGEHHYPWPTKSADF.FKYDDFHLWVTLPDGTHAGVAPVGRRGSGDGQVRIVHA.......R.......H.......GT.PAGQAVAEAQRRR.MM......AVLPPDSPMALEAFEQQIPPGAGTASTPPV...........................................................
H2K669_STRHJ/2-284 ..........................................tradtvaaari--------------------PDTIQPGGVESEN.HPWRIRLVKHPERFESSFFQAAKRTAHKILDEI--DDADLPYGPRPva.......pahWEMHHGGSLWVKTT---SGWRMYRARAGIEWSMQFCAEPSKIDRLRQDAATLVAGFPETL.PALAELGYEEAEELLRTPITDADGVEAWTDSLFNACVPMSRGDHQGILPK.........VPGEHHYPWPVKGADF.FRYDDFQLWVTLPDGTHGAVAPVDRRGSGDGHVRLVLA.......S.......E.......GS.QAADALAEAQDRG.LM......AVLPPNSSAALQAFAHQIESGQRTASGPP-a..........................................................
A0A0X3UWB9_9ACTN/1-295 ..............................................mngaagn---------AAGSASGNATGNQSTAATHTEHEN.HPWTIEVADHPPRVDSPLYTASRDLMRKLV----DTTEDWTYAPGP............YQDHHGGGLWVKDA---NGWMCVFSGLGIEWSAQFCADPAKVDRIRQYATRIIAAFPDTL.PGYAELGYTQGERILTTTIQTPQQIADWTDSIFNASVPLPAGTHSGVLPT.........AAGYHHYPKPIVDIDH.FRADDFQLFVTDDQGLSVAVVPVGPRGSGDGRVRVLAA.......H.......P.......--.-------------.--......------------------------------dsryarhlstpsggkgpemaptteapaapapaaeaergvlpandplaqqafrrqqpqpa
A0A0A8EHJ9_9ACTN/2-278 .............................................nttagnqs-----------------------AADTHTEHEN.HPWTISVADHPKRVDSQQYKDSRAL----MLKLVDTIDDWTFAPGP............YQDHHGGGVWVKDQ---GGWICLFLPLGIEWSAQFCADPAKVDQIRLLAARVIAAFPDTL.PGYAEFGYQDGERLLNTRIETADQVSEWTDSIFNASVPLPAGIHSGVLPT.........AAGYHHYPKPIVDIDH.FRFDDFNLFVEDDQGLSVAVVPVAPRGSGDGRVRVLAAhpssryaK.......H.......LVpPSGGVRPETARDIeSLaaepagAVLPARDPLAEQAFRLQQP-----------mpa........................................................
A0A6P2C112_9ACTN/2-179 ...............................................tatdpv---------------------------HSETET.HTWSVNVPNHPQRADSPEYVAAKK----KMNEIAAQAPGLLYGSGP............FQDHHGSALWLKDS---QGWFMVRNLAGIEWSAQFCANPVKVDLLRQNAKRLYDLLAPELkQELD------PNGLLDTPITDADGVAKWTDSIFNAGVPLHPSFHIGVMPM.........G--KAHAQNPPATAD-.--------------------------------------.......-.......-.......--.-------------.--......------------------------------aqnspdisd..................................................
A0A6P2C112_9ACTN/178-281 .........................................sdqaqaaaapgd---------------------------------.----------------------------------------------............------------------------------------------------------------.------------------------------------------------PE.........PAGVHHYPTPIVDIQL.FKYDDFQLWVTDSEGNPAAVTPVGARGSGVASVHVQYA.......T.......P.......GS.QLAQQKHEQESAG.GA......LILPADHPLAQQAFQNQ-------------...........................................................
A0A0M8WZY7_9ACTN/2-284 ........................................tragtvtrnvmpd----------------------TVKPGGVQSED.HPWRIRLVEHPKRFESPFFQAAKRTAHRILGEI--DDADLPYGPRPva.......pegWEMHHGGSLWVRTA---GGWRMYRARVGIEWSMQFCADPPRIDRLRQDAAELVAAFPETL.PALARLGYEEAEQLLRTPITDADGVEAWTDCLFNSCVPLSRGNHQGILPK.........VPGEHHYPWPVKGADF.FRYDDFQLWVTLPDGTHGAVAPVGRRGSGDGHLRLVHA.......P.......E.......GS.QAAHTLAEAQDQG.LM......AILPPNSSAALQAFAGQIGPGRRSASGPL-a..........................................................
S5UVA5_STRC3/2-281 ................................................ghpep------------------------RPGGFESEN.HPWRIRLVEHPKRFESSQFRAAKDTAHKILH--AMEDADLPYGPRPvdaqqvaknserWEMHHGGSLWVKGS---RGWLMYRARVGIEWSMQFCADPAKVDRLRQDAADLVDAFPLTL.PALADLGYERAEDLLRTPIEDADGVEAWTDSLFNSCVPLSHGNHQGILPS.........VPGEHHYPWPVKGADF.VRYDDFQLWVTLPDGTHGAVAPVDRRGSGDGHVRLTFV.......P.......E.......GS.AAAPTVAEAQDRG.LM......AVLPANSDVALQAFAQQVAPGRRTASGPL-s..........................................................
A0A6I6S896_9ACTN/3-271 ................................................tapst---------------------------HTEHED.EPWTISVADHPPRTDSPQFVASR----KLMNELVGTMDDWPFAPGP............YQDHHGAGMWLKDT---KGWMCIILPLGIEWSAQFCADPAKVDRMRQYALRVIAAFPDTL.PGYVSLGYDDGERLLNTPIQTADQVAEWTDSIFNASVPLPAGAHTGVLPT.........AAGYHHYPKPIVDIDH.FRYDDFQLFVTGPKGLPVAVVPVAPRGSGDGRVQVLAA.......HprspyaaHlvapgpaGR.AAGPADAEARAEAwRG......AILPADDDVARKAFHEQLQ-----------pa.........................................................
A0A3G9IF09_9ACTN/11-232 vlytadhparkdspeyiaarkvlmnqrkggcivcggipdmthpemekvgspkg---------------------------------.----------------------------------------------............LQDHHGGGIYVKDV--L----VGLTPFGMEWSLGWSASPAKV-------AQFVANLNVVL.EALGEPTY-------DSVIKDTPSVMAFVDSKYNANVKLCAPHHVGRMDKpskdaqgheAVGIHEIPYPIWLGQMtCDWDRWDMWAGT--------------------------.......-.......-.......--.-------------.--......------------------------------sgtiavapnpdgtvavlhasdahpdlnrgdvlkadhplama..................
A0A1H4S5P5_9ACTN/1-282 ..............................................mtdllar-----------------PATRSRFQLGKNRKEN.HPWEIRVVKHPERTQSSQFRAAKATAKLILAELAAEDAELPYGPGP............WEMHHGGSLWVKAEEGGGGWRMYRARVGIEWSAQFCADPEKVDRLRREAAELIAAFPLTL.PALDELGYKRARKLLDTPIEDADGVEAWTDSLFNSCVPLTTPDHSGVLPK.........AAGEHHYPWPIKAADY.FRYDDFQLWVTLPDGTNAGVTPVGRRGSGEGELRIVHA.......R.......H.......GS.AAGDAVAEAQRRH.MM......AVVPPDSPIALAAFEQQIPRGARTAAGPLH...........................................................
A0A1H0NHM0_9ACTN/4-281 ............................................dvvttpegp---------------------LELELGKPRKGKvRPWEIQVVKHPTRKESSHFRAAKNAAKKILAALESESGERPYGPRP............WEWHHGGSLWVRSE---SGWRMYRARVGIEWSAQFCADPAKIDRLRREAAELVEAFPLTL.PAMEALGYRRAQELLSMPITDADGVEAWTDSLFNACVPLNKGDHSGILPK.........AAGEHHYPWPLKGADY.FRYDDFQLWVTLPDGTNAGVTPVGRRGSGDGHVRIVHA.......R.......H.......GT.AAGDAVAEAQRRH.MM......AVVPPESPIALAAFEQQIARGAKSASGPL-r..........................................................
A0A1B1B107_9ACTN/1-279 ...................................................ma--------------------QAELHPGGVESEN.HPWKIRLVEHPKRFESAQFTAAKKTAHEILRKM--NDADLPYGPRPvdagp..ehaehWEMHHGGSLWVMGS---HGWLMYRARVGIEWSMQFCADPDKVERLRQEAAELVDAFPRTL.PALAELGYDRAEELLRTPIKDADGVEAWTDSLFNACVPLSRENHQGILPK.........VPGEHHYPWPVKGADF.VRYDDFQLWVTLPDGTHGAVAPVDRRGSGDGHVRLAFA.......P.......E.......GS.AAAATLAEAQDRG.LM......AVLPANSPVALQAYSRQISPDRRTASGPL-s..........................................................
A0A553ZRK3_9ACTN/2-266 .................................................tspe-------------------------HGHPEHED.FPWTISVADHPPRTESSQYRASRK----LMGDLVGTTGDWVFAPGP............YQDHHGGGVWVKDS---DGWLCLFLPLGIEWSAQFCADPSKVDHVRRYAARVVGAFPDTL.PGYASFGYDDGQRLLDTPIETADQVAEWTDSIFNASVPLPAGTHSGVLPK.........TAGYHHYPKPIVDIDH.FRYDDFALFVTDDSGLPAAVVPISPRGSGDGRVRLLAA.......H.......P.......SS.PYA----------.--......------------------------------krltspgpaepsarteealasgeernvlpaddllaqqafrkqs................
A0A3N4ZM04_9ACTN/2-279 ...............................................andrsa---------------TATKTPPSLTFGKTERED.HPWEIQLVKHQERTESAEFRAAKDTANKILKELAT--TERPYGPGP............YEMHHGGSLWVKTD---AGWRMFRARVGIEWSMQFCADPAKVDRLRQEAADLVAAFPETL.PALEALGYKRARKLLETPITDAEGVAAWTDSLFNACVPLTRGDHQGVLPK.........AAGEHHYPWPIKGADY.IRYDDFNLWVTLPDGTHAGVAPVGARGSGDGRLRIVHA.......R.......H.......GT.PAGDVLAKAQRRR.VM......AVLPADSPMALEAFQQQITPGARTAAAR--pr.........................................................
A0A3Q9G3B0_STRLT/3-215 ......................................srkqmhklvdsldhp---------------------------------.----------------------------------------FYGPEP............VEDHHGGGLWVKDD---QGWFMVRNMAGIEWSAQFCADPAKVDLLRQNARRLYAGFP---.DAVEELGI---RELLDTPITDADGVQRWTDSICNASVPLAKKDHSAELPK.........GGGVHHYPSPITEIGF.FKRDDFILWVTDDAGEPVAVAPVDRRGSGDGRVNVLFA.......S.......E.......QS.PLHAELHKAQAKG.QA......LVLDAGHAVARAAFARQ-------------a..........................................................
A0A7W7LNW8_9ACTN/1-255 .......................................maadatnakadpsq--------------------------PHTEAEK.LGWEINIPGHAPRQDSPAYIASRKRMHELLATL----DHPFYGPEP............VEDHHGGGLWLKDD---DGWFMVRNLVGIEWSAQFCADPAKVDLLRQNARRIYTAFPQ--.-AVEELGI---RELLDTPITDAAGVANWTDSICNASVPLEHKDHSAELPS.........GGGVHHYPSPITEIGF.FKMDDFELWVNDEQGQTVAVAPVDKRGKGDARVHVLYA.......A.......Q.......DS.ELYPKLQQAQAQG.DV......LLLDPKSQVAQAAFAKQ-------------t..........................................................
A0A1Q5G5G9_9ACTN/2-284 .........................................arsgslasspia---------------------DSLKPGGIESEN.HPWKIRLVEHPERFESSFFRAAKKTVHKILDEMS--DTDLPYGSRPag.......sehWEMHHGGSLWVRGA---GGWRMYRARVGIEWSMQFCAEPVKVDRLRQEAAELIDAFPLTL.PALAGLGYEEADALLRAPIKDADGVEAWTDSLFNACVPMSHGNHQGILPK.........VPGEHHYPWPVKGADF.VRYDDFQLWVTLPDGTHGAVCPVDRRGSGDGHVRLVHV.......P.......E.......GS.RAAEAVAEAQEQG.LM......AVLPPNSSAALQAFAGQIGRGRRTAAGH--la.........................................................
A0A117PK76_9ACTN/1-279 .............................................mtdvltrp------------------AARDEFELGRPRKGN.HPWEIRVVKHPERSESSHFRAAKKTAKKILEELEADGGELPYGPGP............WEMHHGGSLWVRAE---SGWRMYRARVGIEWSAQFCADPVKVDRLRREAAELIEAFPLTL.PALDALGYKRARDLLDTPITDADGVEAWTDSLFNACVPLSTANHSGVLPK.........AAGEHHYPWPVKAADY.FRYDDFELWVRLPDGTNAAVTPVDRRGSGEGAVRIVHA.......R.......H.......GT.PAGDALAEAQRRR.MM......AVVPPDSPIALAAFEQQIPRGSKTASVPL-r..........................................................
A0A0M9YQT8_9ACTN/1-286 .....................................................MADAGSVS---VPGAAGRGAGAVLDVDHTHGET.RPWEIRIVKHPERSESAHFRAAKKVAKRILQELGTDGAEPPYGPGP............WEMHHGGSLWVMTG---SGWRMYRARVGIEWSMQFCADPEKVDRLRQEAAELVAAFPFTL.PALDALGYKRARDLLSTPVTDADGVEAWTDSLFNACVPMSNPHHSGVLPK.........AAGEHHYPWPTKSADF.FKFDDFQLWVTLPDGTHAGVAPVDRRGSGDGHVRIVHA.......R.......H.......GT.PAGDILAEAQRRR.MM......AVAPPDSPVALAAFEQQIRPGARSASTR--ps.........................................................
#=GC seq_cons ..............................................hssssts........................t.stscpEs.HPWpIplscHPpRh-Ss.FpAAKchh+clLtph..pss-hPYGPtP............aEhHHGGSLWV+ss...sGWhMaRARlGIEWShQFCADPsKVDRLRQ-AAcLlsAFP.TL.PALspLGYccAccLLcTPIpDADGVpAWTDSLFNACVPLspusHpGlLPK.........uuGEHHYPaPlKuADa.FRYDDFpLWVTLPDGTpuAVsPVs+RGSGDG+VRllaA.......p.......c.......Go..AusslAEAQcct.hh......AVLPssSshAhtAFtpQl............s..........................................................
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